| "Medullary necrosis are not caused by vascular lesions and differ therefore from infarct-like necrosis of the bone." | ( Masshoff, W; Schettler, J, 1975) |
| "Skin necrosis is an unusual complication following venography of the legs." | ( Capek, V; Spigos, DG; Thane, TT, 1977) |
| "Cell death and necrosis are important reactions of liver cells to injury that play a role in a wide variety of human liver diseases." | ( El-Mofty, SK; Farber, JL, 1975) |
| "Bilateral putaminal necrosis is characteristic of methanol poisoning." | ( Chia, LG; Hsieh, FY; Leu, TM, 1992) |
| "Skin necrosis is a well-known yet rare complication of oral anticoagulant therapy." | ( Connelly, JE; Gardner, JH; Humphries, JE, 1991) |
| "Coumarin skin necrosis is a rare and usually unpredictable complication of coumarin therapy, occasionally leading to death." | ( Blais, FX; Brooks, LW, 1991) |
| "The necrosis is probably multifactorial in origin, with ischaemia and sepsis contributing factors." | ( Bone, JM; Campbell, IT; Coakley, JH; Green, CJ; Griffiths, RD; Helliwell, TR; McClelland, P; Wagenmakers, AJ, 1991) |
| "Anterior segment necrosis is an acute or chronic process occasioned by embarrassment of the blood supply of the anterior segment of the eye." | ( Pfister, RR, 1991) |
| "This augmented necrosis is averted by prolonged treatment with hyperbaric oxygen." | ( Marzella, L; Muhvich, K; Myers, RA, 1986) |
| "Cardiac myonecrosis is a potential adverse effect of the hypertensive crisis associated with monoamine oxidase inhibitor use." | ( Liu, LX; Rustgi, AK, 1987) |
| "Rectal necrosis is a complication of injury during the administration of phosphates enemata which, although rare, deserves greater awareness." | ( Carr, N; Corrado, OJ; Smith, I; Young, A, 1987) |
| "Acute hepatic necrosis is described in a 60 year old woman treated with naftidrofuryl for 5 months." | ( de Caestecker, JS; Heading, RC, 1986) |
| "The extent of necrosis is a combination of cellular damage that occurs during both the period of ischemia and the period of reperfusion." | ( Labbe, R; Lindsay, TF; Mickle, DA; Romaschin, AD; Walker, PM, 1987) |
| "Since the amount of necrosis is proportional to dose from about 10(2) to 10(5) mug/kg, while the changes in [Ca](m) are not proportional to dose over this entire range, it is concluded that ISO-induced myocardial necrosis is not mediated exclusively by flooding of heart muscle with plasma-derived calcium, although this is undoubtedly an important factor." | ( Bloom, S; Davis, DL, 1972) |
| "Focal white matter necrosis is frequently seen in the brains of infants with perinatal cerebral hypoperfusion." | ( Becker, LE; Nishimura, M; Takashima, S; Tanaka, J, 1984) |
| "As necrosis is a common occurrence in solid tumours, we have studied the interactions of saline extracts from the necrotic regions of rat Walker-256 tumours and mouse Gardner lymphosarcomas on the transmembrane, in vitro migration of Walker and Gardner cancer cells, and rat and mouse peritoneal macrophages." | ( Turner, GA; Weiss, L, 1980) |
| "Toxic branchionecrosis is a term referring to a disease when the pathological processes are caused by ammonia intoxication and autointoxication, the main role being played by pH value." | ( Hornich, M; Tománek, J, 1983) |
| "Cardionecrosis is the irreversible consequence of cardiotoxicity." | ( Godfraind, T, 1984) |
| "Today phosphorus necrosis is extremely rare, but the former presence of the disease points up both apathy and courage in the identification and eradication of a remarkably disfiguring work-caused disease." | ( Felton, JS, 1982) |
| "Acute tubular necrosis is a relatively innocent complication of renal transplantation and, if one avoids assaulting patients with invasive diagnostic procedures, does not give rise to an increased mortality nor, in the long run, to an increased loss of kidneys." | ( Brophy, D; Kjellstrand, CM; Najarian, JS, 1980) |
| "Coumarin necrosis is a poorly understood phenomenon unlikely to respond to therapy." | ( Fricker, MP; Schleicher, SM, 1980) |
| "As such, necrosis is probably due to limitations in nutrient diffusion upward from the agar rather than oxygen diffusion downward." | ( Glaser, DA; Konrad, MW; Storrie, B, 1980) |
| "Local skin necrosis is a serious complication of doxorubicin (Adriamycin) infiltration in man." | ( Alberts, DS; Chen, HS; Dorr, RT, 1980) |
| "Tissue necrosis is a rare but serious complication of intramuscular administration of medicines, including nonsteroidal antiinflammatory drugs (NSAIDs)." | ( O'Connor, N; Pillans, PI, 1995) |
| "Necrosis is a set of precise biochemical and cellular lesions which culminate in cell destruction." | ( Watson, AJ, 1995) |
| "Skin necrosis is an uncommon complication associated with coumarin or heparin therapy." | ( Balestra, B, 1995) |
| "Submassive hepatic necrosis is a potentially fatal complication which is usually recognized on the liver biopsy and histological examination or autopsy." | ( Singh, A; Thakur, R, 1995) |
| "Skin necrosis is a rare complication of treatment with coumarin derivatives." | ( Pettyjohn, FS; Sternberg, ML, 1995) |
| "Tongue necrosis is a rare complication in giant cell arteritis, an entity in which both temporal arteritis and rheumatic polymyalgia may be included as two different manifestations of the same pathologic process." | ( De Vicente Rodríguez, JC; González García, M; Junquera Gutierrez, LM; Llorente Pendás, S; López Arranz, JS, 1994) |
| "Necrosis is limited to superficial, fully differentiated mucoid cells, which--after the cell death has occurred--are desquamated into the lumen as fragments of irregular shape." | ( Pipan, N; Sterle, M, 1994) |
| "This necrosis is measurable and sufficiently reproducible." | ( Baux, S; Cothier-Savey, I; Mimoun, M, 1994) |
| "The resulting necrosis is believed to result, at least in part, from the leakage of lysosomal enzymes into the cytoplasm." | ( Gruenberg, J; Marjomäki, V; Ritamäki, V, 1994) |
| "The tumour necrosis is particularly extensive upon injection of 4." | ( Caggiari, L; Jori, G; Milanesi, C; Villanueva, A, 1994) |
| "Apoptosis and necrosis are two types of cell death with different morphologic features." | ( Doupe, A; Drexler, HC; Fernandez, PA; Rangini, Z; Rotello, RJ; Yuan, J, 1994) |
| "Skin necrosis is a recognized potential consequence of an inadvertent extravasation of Vinca alkaloids in the surrounding tissues during i." | ( Bertelli, G; Dini, D; Forno, GB; Gozza, A; Pronzato, P; Rosso, R; Silvestro, S; Venturini, M, 1994) |
| "Apoptosis and necrosis are two fundamental types of cell death." | ( Buja, LM; Eigenbrodt, EH; Eigenbrodt, ML, 1993) |
| "Hemorrhagic tumor necrosis is an inflammatory event that leads to selective destruction of malignant tissues, with both potentially toxic and beneficial consequences." | ( Chapman, PB; Houghton, AN; Minasian, LM; Morrison, ME; Nathan, CF; Rosenblum, M; Steffens, T; Szatrowski, TP; Williams, L, 1994) |
| "The original term, necrosis, is now reserved for the generally destructive series of events which include the release of lysosomal enzymes and loss of cell membrane integrity." | ( Studzinski, GP; Tepper, CG, 1993) |
| "Apoptosis and necrosis are two important mechanisms of cell death." | ( Brown, D; Cohen, GM; Ormerod, MG; Snowden, RT; Sun, XM, 1993) |
| "Muscle necrosis is also a known but rare side effect of intramuscular administration of drugs (the "Nicolau syndrome") in which non-steroid anti-inflammatory drugs are often implicated." | ( Kvam, AM; Rygnestad, T, 1995) |
| "Skin necrosis is a rare but serious complication of oral anticoagulation with coumarin derivatives." | ( Jillella, AP; Lutcher, CL, 1996) |
| "Progressive tissue necrosis is a unique reaction to spinal cord trauma in which the site of injury is gradually transformed into a large, cavity-filled lesion." | ( Guth, L; Krebs, CJ; Zhang, Z, 1997) |
| "Apoptosis and necrosis are generally recognized as two distinct pathways of cell death, based on biochemical and morphological characteristics." | ( Martin, LJ; Portera-Cailliau, C; Price, DL, 1997) |
| "Apoptosis and necrosis are considered conceptually and morphologically distinct forms of cell death." | ( Castoldi, AF; Kühnle, S; Leist, M; Nicotera, P; Single, B, 1997) |
| "Necrosis is therefore not always a passive process but may involve the activation of intracellular signaling pathways similar to those that mediate apoptosis." | ( Bradham, C; Brenner, DA; Czaja, MJ; Xu, Y, 1997) |
| "Necrosis is a passive, catabolic process, always pathological, that represents a cell's response to extreme accidental or toxic insults." | ( Biola, A; Bréard, J; Pallardy, M; Renvoizé, C, 1998) |
| "Bone marrow necrosis is a rare clinical condition often associated with hematological malignancy." | ( Li, CY; Markovic, SN; Phyliky, RL, 1998) |
| "Skin necrosis is an uncommon complication of warfarin (Coumadin; Dupont Pharma, Wilmington, DE) therapy." | ( Beeson, MS; Gelwix, TJ, 1998) |
| "Scalp necrosis is a valuable sign that frequently is misdiagnosed until visual loss occurs." | ( Cornblath, WT; Dudenhoefer, EJ; Schatz, MP, 1998) |
| "Flap necrosis is still a significant complication in all types of flap surgery." | ( Akbaş, H; Karacaoğlan, N, 1999) |
| "Necrosis is a common feature of invasive carcinoma of the breast and is caused by chronic ischaemia leading to infarction." | ( Harris, AL; Landers, RJ; Leek, RD; Lewis, CE, 1999) |
| "Calcific myonecrosis is a rare and late sequela of compartment syndrome, which becomes symptomatic years after the initial trauma." | ( Agildere, M; Demirhan, B; Demirörs, H; Isiklar, ZU; Tandogan, RN; Tuncay, IC, 1999) |
| "While necrosis is known as a major mechanism for the loss of viability of skeletal muscle following ischaemia and reperfusion, much less is known of the role of apoptosis." | ( Hurley, JV; Knight, KR; Messina, A; Morrison, WA; Stewart, AG; Zhang, B, 1999) |
| "Necrosis is associated with rapid metabolic collapse that leads to cell swelling, early loss of plasma membrane integrity, and ultimate cell rupture, in which cytosolic contents leak from necrotic cells causing injury to and inflammation of the surrounding tissue." | ( Hirata, K; Katsuramaki, T; Ura, H, 1999) |
| "Necrosis is well characterized in kidney cells, but pathways leading to apoptosis are less clear." | ( Stevens, JL; van de Water, B; Wang, Y; Zhan, Y, 1999) |
| "Skin necrosis is a rare but serious side-effect of treatment with warfarin." | ( Cook, MK; Ludlam, CA; Penman, ID; Stewart, AJ, 1999) |
| "Because myocardial necrosis is associated with myocardial thinning, preserved EDWT may provide a simple index of myocardial viability that is readily available from the resting echocardiogram." | ( Cwajg, E; Cwajg, JM; He, ZX; Nagueh, SF; Olmos, LI; Quinones, MA; Qureshi, U; Verani, MS; Winters, WL; Zoghbi, WA, 2000) |
| "Colonic necrosis is an unusual complication after treatment of hyperkalemia with sodium polystyrene sulfonate (SPS, Kayexalate) in sorbitol." | ( Barbul, A; Dardik, A; Efron, G; Harrison, MG; Moesinger, RC, 2000) |
| "TNF-R55-mediated necrosis is not affected by the dominant negative deletion mutant of the Fas-associated death domain (FADD-(80-205)) that lacks the N-terminal death effector domain." | ( Boone, E; De Wael, N; De Wilde, G; Fiers, W; Haegeman, G; Van Loo, G; Vanden Berghe, T; Vandenabeele, P; Vercammen, D, 2000) |
| "Necrosis is a pathological scenario of cell death, which entails an inflammatory response in animal tissues." | ( Lagunova, EM; Oleskin, AV; Samuilov, VD, 2000) |
| "This necrosis is not a direct correlate of mycobacterial growth or of the expression of host cell factors, but is preceded by permeation of the A549 cell membrane and requires infection with live bacilli." | ( Dobos, KM; King, CH; Quinn, FD; Spotts, EA, 2000) |
| "Coumarin necrosis is a rare but clinical very important complication of therapy with coumarin derivatives." | ( Helling, L; Pfeiffer, D; Rühlmann, C; Seyfarth, HJ; Siegemund, A; Woinke, M, 2001) |
| "Cartilage necrosis is prominent during the early stages after laryngotracheoplasty." | ( Carron, JD; Derkay, CS; Greinwald, JH; Oberman, JP; Werner, AL, 2001) |
| "Calcific myonecrosis is a rare complication of the leg after trauma." | ( Chen, WJ; Wang, JW, 2001) |
| "Small bowel necrosis is known as a rare, but serious complication of jejunal tube feeding." | ( Frey, C; Krähenbühl, L; Takala, J, 2001) |
| "Late temporal lobe necrosis is a well-known and serious complication in patients with nasopharyngeal carcinoma (NPC) following radiotherapy." | ( Chan, JH; Cheung, YK; Fong, D; Lai, KF; Leung, TW; Luk, SH; Ramsey, RG; Tsui, EY; Wong, KP; Yuen, MK, 2001) |
| "Necrosis is the main way in which cells of the three HSV-TK-transduced cells lines die." | ( Cui, Q; Gao, J; Liu, T; Zhang, L, 2000) |
| "Apoptosis and necrosis are critical parameters of pancreatitis, the mechanisms of which remain unknown." | ( Gukovskaya, AS; Gukovsky, I; Jung, Y; Mouria, M; Pandol, SJ, 2002) |
| "This progressive necrosis is analogous to that seen with brown recluse spider bites, where dapsone is an established mode of therapy, minimizing the area of tissue loss by a proposed antiinflammatory mechanism." | ( Bayati, S; Brown, RE; Neumeister, M; Sommer, NZ, 2002) |
| "NO-induced CMC necrosis is likely mediated by PARP activation which occurs as a consequence of caspase activation." | ( Imamura, H; Kido, M; Kobayashi, Y; Ninomiya, H; Nogi, S; Okada, T; Otani, H; Uchiyama, T, 2002) |
| "Bile duct necrosis is a serious complication in arterial infusion chemotherapy, and the infusion chemotherapy should be suspended or the dose should be reduced for patients with abnormalities shown by hepato-biliary function tests." | ( Arai, K; Iwasaki, Y; Kimura, Y; Takahashi, K; Takahashi, T; Yamaguchi, T, 2002) |
| "Calcific myonecrosis is a rare, late sequela of trauma occurring almost exclusively in the lower extremity which may be confused with an aggressive primary neoplasm." | ( Damron, TA; Hojnowski, L; Holobinko, JN; Scerpella, PR, 2003) |
| "NO-induced necrosis is mediated by energy failure speeded by thiol depletion." | ( Borutaite, V; Brown, GC, 2003) |
| "Cutaneous necrosis is an infrequent but well-documented complication of oral anticoagulants." | ( Lázaro, P; Lecona, M; Longo, I; Valdivielso, M, 2004) |
| "Apoptosis and necrosis are clearly distinguished by their morphology, although in the absence of phagocytosis, the late stage of apoptosis is associated with secondary necrotic cell death, which is hard to distinguish from necrotic cell death." | ( Brouckaert, G; D'Herde, K; Denecker, G; Vadimovisch Krysko, D; Vanden Berghe, T; Vandenabeele, P, 2004) |
| "Apoptosis and necrosis are two forms of cell death that can occur in response to various agents and oxidative damage." | ( Araujo, MS; Cruz-Silva, I; Godinho, RO; Gozzo, AJ; Juliano, MA; Meirelles, FV; Nunes, VA; Sampaio, CA; Sampaio, MU; Viel, TA, 2005) |
| "Clostridial myonecrosis is a rapidly progressive disease consisting of muscle necrosis and systemic toxicity." | ( Arnold, L; Langhan, M, 2005) |
| "Conjunctival necrosis is a rare anterior segment complication of intravitreal injection of TA." | ( Prasad, S; Srinivasan, S, 2005) |
| "The mechanisms of necrosis are still unclear." | ( Harada, H; Ikari, A; Miwa, M; Nagatani, Y; Takagi, K; Tsukimoto, M, 2005) |
| "Apoptosis and necrosis are distinguished by modality primarily." | ( Chang, J; Hu, Q; Tao, L; Wang, Z; Xie, M; Yan, G, 2005) |
| "Parenchymal necrosis is a major complication of pancreatitis; also, the severity of experimental pancreatitis correlates directly with necrosis and inversely with apoptosis." | ( Gukovskaya, AS; Gukovsky, I; Hong, P; Lugea, A; Mareninova, OA; Pandol, SJ; Sung, KF, 2006) |
| "Injection necrosis is a rare but clinically important potential complication caused by interruption of the vascular supply to the area by compression, injury, and/or obstruction of the vessel(s)." | ( Cohen, JL; Glaich, AS; Goldberg, LH, 2006) |
| "Necrosis is typically the consequence of acute metabolic perturbation with ATP depletion as occurs in ischemia/reperfusion and acute drug-induced hepatotoxicity." | ( Gores, GJ; Lemasters, JJ; Malhi, H, 2006) |
| "In contrast, necrosis is associated with severe mitochondrial damage and maximal protein S-glutathionylation." | ( Di Simplicio, FC; Di Simplicio, P; Di Stefano, A; Ettorre, A; Frosali, S; Leonini, A; Priora, R, 2006) |
| "Scalp necrosis is an uncommon manifestation of giant cell arteritis (GCA)." | ( Heinen, V; Smitz, SS; Van Damme, H, 2006) |
| "Scalp necrosis is rare in patients with giant cell arteritis." | ( Flett, N; Landis, SJ; Selinger, S, 2005) |
| "Heparin necrosis is characterised by widespread life-threatening cutaneous necrosis and systemic thrombosis, in which fatal progression of disease can only be halted by stopping heparin therapy." | ( Knight, AG; Patel, GK, 2005) |
| "Cell death by necrosis is attributed to H2O2 produced by oxidation of alpha-amino acids." | ( Ande, SR; Draxl, S; Ferrando-May, E; Ghisla, S; Kommoju, PR; Macheroux, P; Murkovic, M, 2006) |
| "As apoptosis and necrosis are known to exist during experimental goiter development and involution, we studied them in ten Tunisian multinodular endemic goiters, five of them having received a chronic excess of iodine during six months." | ( Boubaker, S; El May, A; El May, MV; Ladgham, A; Zekri, S, 2005) |
| "The FA-induced necrosis is Ca(2+)-dependent." | ( Criddle, DN; Petersen, OH; Sutton, R, 2006) |
| "Calcific myonecrosis is a rare complication of previous trauma that presents as a tumor-like calcified mass years after an initial injury, most commonly affecting the anterior compartment of the lower leg." | ( Ainsworth, K; Finlay, K; Friedman, L, 2007) |
| "Subcutaneus fat necrosis is an uncommon disease which may be complicated with potentially fatal hypercalcemia." | ( Bottu, J; Trullemans, B; Van Nieuwenhuyse, JP, 2007) |
| "Because necrosis is prominent in ischemia, trauma and possibly some forms of neurodegeneration, further biochemical comprehension and molecular definition of this process could have important clinical implications." | ( Golstein, P; Kroemer, G, 2007) |
| "Vesical necrosis is a rare but devastating complication of hydrodistention." | ( Allee, T; Maher, MG; Mourtzinos, A; Payne, CK; Raz, S; Rodríguez, LV; Zabihi, N, 2007) |
| "Necrosis is a frequent condition during AIDS, notably in organs targetted by opportunistic infections." | ( Boniface, R; Gozlan, J; Jaulmes, A; Maréchal, V; Nasreddine, N; Strauss, F; Thierry, S, 2007) |
| "Injection necrosis is a rare but clinically significant side effect." | ( Cohen, JL; Duffy, D; Hirsch, RJ; Lupo, M, 2007) |
| "Skin necrosis is a rare complication in intensive care unit." | ( Denninger, MH; Mantz, J; Paugam-Burtz, C; Perbet, S; Trouiller, P, 2007) |
| "Skin flap necrosis is one of the hazards encountered in plastic and reconstructive surgery." | ( Gu, Y; Hiura, A; Inoue, K; Kim, D; Qi, Z; Sumi, S, 2007) |
| "Bone marrow necrosis is a rare cause of bone marrow failure." | ( Franceschetti, S; Gaidano, G; Ramponi, A; Rossi, D; Stratta, P, 2008) |
| "However, necrosis is characterized mostly in negative terms by the absence of caspase activation, cytochrome c release and DNA oligonucleosomal fragmentation." | ( D'Herde, K; Krysko, DV; Vanden Berghe, T; Vandenabeele, P, 2008) |
| "If mainly necrosis is noted during surgery, continuation of adjuvant temozolomide is logical." | ( Brandsma, D; Sminia, P; Stalpers, L; Taal, W; van den Bent, MJ, 2008) |
| "Focal necrosis is a key pathologic feature that distinguishes glioblastoma from lower grade glioma." | ( Aldape, KD; Ali-Osman, F; Gong, W; Huang, S; Kanzawa, T; Kondo, S; Lang, F; Sawaya, R; Suki, D; Xie, TX, 2008) |
| "However, tumor necrosis is incomplete, and the growth of residual cells is sustained by a microvascular network." | ( Christophi, C; Daruwalla, J; Greish, K; Iyer, A; Maeda, H; Malcontenti-Wilson, C; Muralidharan, V, 2009) |
| "Myocardial necrosis is a serious adverse effect that results from the administration of some medications; therefore, when it is observed during preclinical studies it becomes a major drug development concern." | ( Izumisawa, N; Kajikawa, S; Matsumoto, M; Nakatsuji, S; Oishi, Y; Shirakawa, T; Tabata, H; Takeuchi, A; Toyoda, Y; Watanabe, K, 2008) |
| "Sporadic necrosis is observed in both apoptosis-competent and deficient tumors evident by tumor cell morphology, extracellular release of high mobility group box 1 protein, and activation of innate immune cells in CP-treated tumors." | ( Crawford, HC; Ditsworth, D; Fan, Y; Guerriero, JL; Zhao, F; Zong, WX, 2008) |
| "Pancreatic necrosis is a serious complication of acute pancreatitis." | ( Khalid, A; Muddana, V; Papachristou, GI; Slivka, A; Whitcomb, DC, 2009) |
| "Tongue necrosis is a rare complication in arteritis temporalis." | ( Olesen, JB, 2009) |
| "AOA tumors with necrosis are to be considered WHO grade IV tumors (GBM)." | ( Allgeier, A; Brandes, AA; Bromberg, JE; Gorlia, T; Grisold, W; Ibdaih, A; Kouwenhoven, MC; Kros, JM; Lacombe, D; Mirimanoff, R; Mokhtari, K; Sipos, L; Teepen, JL; van den Bent, MJ; van Duinen, SG; Vandenbos, F; Vecht, CJ; Wesseling, P, 2009) |
| "Tissue necrosis is a rare but serious complication of intramuscular injections." | ( Arad, E; Uri, O, 2010) |
| "Calcific myonecrosis is a rare condition characterized by a calcified lesion." | ( Ihara, K; Imagama, T; Muramatsu, K; Seki, T; Taguchi, T, 2009) |
| "GCA with scalp necrosis is also associated with an increased mortality (standard mortality ratio [SMR], 4." | ( Ehrchen, JM; Fischer, T; Kruse-Loesler, B; Luger, TA; Presser, D; Sunderkoetter, C; Tsianakas, A, 2009) |
| "Although skin necrosis is frequently cited as a complication of open bursectomy, there is limited information in the medical literature on the etiology and management of this rare but serious complication." | ( Gendernalik, JD; Sechriest, VF, 2009) |
| "Programmed necrosis is a mechanism of cell death that has been described for neuronal excitotoxicity and ischemia/reperfusion injury, but has not been extensively studied in the context of exposure to bacterial exotoxins." | ( Chakravorty, A; Kennedy, CL; Lyras, D; Rood, JI; Smith, DJ, 2009) |
| "The subsequent necrosis is not prevented by autophagy as an alternative energy source." | ( Daniel, PT; Fischer, U; Horn, S; Janssen, K; Niemann, MT; Schulze-Osthoff, K, 2009) |
| "Postembolization necrosis is a rare complication of the area, and there are very few similar reports in the literature." | ( Lazaridis, N; Ntomouchtsis, A; Venetis, G; Zouloumis, L, 2010) |
| "In solid tumours, necrosis is commonly found in the core region in response to metabolic stress that results from oxygen and glucose depletion (OGD) due to insufficient vascularization and has been implicated in tumour progression." | ( Han, SI; Jeon, HM; Kang, HS; Kim, CH; Kim, SM; Ko, AR; Lee, SY; Park, HG, 2010) |
| "Calcific myonecrosis is a rare, late complication of compartment syndrome in the lower extremity." | ( Monga, P; Papanna, MC; Wilkes, RA, 2010) |
| "Tumour necrosis is thought to indicate a poor prognosis and to contribute to acquisition of chemoresistance in solid tumours; however, the mechanism underlying necrosis-mediated chemoresistance remains unclear." | ( Jeon, HM; Jeong, EK; Kang, HS; Kim, CH; Lee, SY, 2010) |
| "Cell necrosis is central to the progression of numerous diseases, and imaging agents that can detect necrotic tissue have great clinical potential." | ( Brown, M; Dasari, M; Davis, M; Kim, D; Lee, S; Murthy, N; Sy, J, 2010) |
| "Calcific myonecrosis is a rare late post-traumatic condition, in which a single muscle is replaced by a fusiform mass with central liquefaction and peripheral calcification." | ( Chun, YS; Shim, HS, 2010) |
| "Necrosis is associated with an increase in plasma membrane permeability, cell swelling, and loss of membrane integrity with subsequent release of cytoplasmic constituents." | ( Armisén, R; Cerda, O; Eguiguren, AL; Leiva-Salcedo, E; Olivero, P; Riveros, A; Simon, F; Stutzin, A; Varela, D, 2010) |
| "Secondary necrosis is the typical outcome of apoptosis in unicellular eukaryotes but, importantly, it may also occur in multicellular animals and has been implicated in the genesis of important human pathologies." | ( Silva, MT, 2010) |
| "In IRAC 2091, leaf necrosis are quite similar to those observed on Solaris but the infected plant cell, as well as the haustoria, show high electron dense cellular particles without any recognisable organelles, probably related to the effect of the toxic compound pterostilbene, which is synthesised in this grape cultivar." | ( Alonso-Villaverde, V; Gindro, K; Spring, JL; Viret, O; Voinesco, F, 2011) |
| "Calcific myonecrosis is a rare late complication of trauma, affecting almost exclusively the lower limb." | ( Chini, M; Lazanas, M; Lioni, A; Maris, J; Papanikolaou, A; Pavlakis, D, 2011) |
| "Tubular necrosis is derived from epithelial cell death by apoptosis and necrosis in the proximal and distal tubuli." | ( Cannata-Andía, JB; López-Hernández, FJ; López-Novoa, JM; Piedrafita, FJ; Sancho-Martínez, SM, 2011) |
| "Cutaneous necrosis is one of the most annoying complications of reticular and spider vein sclerotherapy." | ( Brunner, F; Neuhold, N; Pavlović, MD; Schuller-Petrović, S; Wölkart, G, 2011) |
| "Cerebral radionecrosis is a significant side effect in radiotherapy for brain cancer." | ( Fossati, P; Hasegawa, A; Himukai, T; Kanai, T; Kase, Y; Matsufuji, N; Minohara, S; Mizoe, J; Nagano, A; Tameshige, Y, 2011) |
| "Bone marrow necrosis is a very rare adverse event in malignant GIST." | ( Akcakaya, MO; Aras, Y; Bilgic, B; Unal, OF; Unal, SN, 2012) |
| "Bilateral striatal necrosis is usually associated with either endogenous or exogenous toxins, and with poor neurodevelopmental outcomes." | ( Connolly, DJ; Khan, R; Mordekar, SR; Nandish, S; Rittey, CD, 2012) |
| "Necrosis is due to prolonged vasoconstriction of arteries." | ( Ben Hadj Hamida, F; Ben Rayana, N; Ghorbel, M; Knani, L; Krifa, F; Mahjoub, H; Touzani, F; Yakoubi, S, 2012) |
| "The ADC value of necrosis is especially helpful in discriminating metastasis from tuberculosis." | ( Chen, J; Liang, B; Shen, J; Ye, R; Zhang, Y; Zhong, J, 2013) |
| "Cutaneous necrosis is a rare complication of vitamin K antagonist therapy." | ( Alhenc-Gelas, M; Batard, ML; Cribier, B; Mazurier, I; Merklen-Djafri, C; Roth, B; Samama, MM; Tortel, MC, 2012) |
| "Calcific myonecrosis is a rare entity with only 57 cases reported in the English literature to date." | ( De Carvalho, BR, 2012) |
| "Radiation necrosis is a major complication of radiation therapy." | ( Armour, M; Ford, E; Fu, DX; Tryggestad, E; van Zijl, PC; Wang, S; Wen, Z; Zhou, J; Zhou, T, 2012) |
| "Partial necrosis is a main complication of reverse sural artery flap." | ( Dong, ZG; He, AY; Liu, LH; Luo, SH; Luo, ZB; Ni, JD; Wei, JW; Zheng, L, 2012) |
| "Glans necrosis is a rare complication after circumcision and may occur secondary to cautery ." | ( Afsar, F; Aminsharifi, A; Tourchi, A, 2013) |
| "Necrosis is commonly found in the core region of solid tumours due to metabolic stress such as hypoxia and glucose deprivation (GD) resulting from insufficient vascularization." | ( Jeon, HM; Ju, MK; Kang, HS; Kim, CH; Lee, SY; Park, HG, 2013) |
| "RIP3-dependent necrosis is not postapoptotic, and the increased primary necrosis in advanced atherosclerotic lesions most likely resulted from the increase of RIP3 expression." | ( Du, J; Han, F; Han, J; Huang, D; Huang, J; Huang, Y; Huang, Z; Jin, G; Li, H; Lin, J; Ma, J; Qiao, M; Ren, J; Wu, J; Wu, Q; Yang, M; Zhang, D; Zhang, Z, 2013) |
| "Apoptosis and necrosis are two major forms of cell death observed in normal and disease pathologies." | ( Chan, FK; De Rosa, MJ; Moriwaki, K, 2013) |
| "Necrosis is a mechanism used by bacteria to exit macrophage, evade the host defenses, and disseminate while apoptosis is associated with diminished pathogen viability." | ( Behar, SM; Divangahi, M; Remold, H, 2013) |
| "Ischemia and necrosis are complications of small bowel obstruction (SBO) and require rapid surgical treatment." | ( Cosse, C; Fuks, D; Mauvais, F; Regimbeau, JM; Scotte, M, 2013) |
| "Necrosis is a form of cell death characterized by cytoplasmic and organelle swelling, compromised -membrane integrity, intracellular acidification, and increased levels of reactive oxygen species (ROS) and cytosolic Ca(2+)." | ( Gartmond, TD; McCall, K; Meehan, TL; Timmons, AK, 2013) |
| "Programmed necrosis is important in many (patho)physiological settings." | ( Adam, D; Chan, FK; Davarnia, P; Herdegen, T; Kabelitz, D; Lange, A; Linkermann, A; Mathieu, S; Rittger, A; Schütze, S; Sosna, J; Thon, L; Voigt, S, 2014) |
| "Necrosis is a form of cell death that occurs in a variety of pathological conditions but can also be the result of therapy in cancer treatment." | ( Bormans, GM; Cleynhens, BJ; Cona, MM; Dyubankova, N; Lescrinier, E; Li, J; Ni, Y; Prinsen, K; Vanbilloen, H; Verbruggen, AM, 2013) |
| "Apoptosis and necrosis are two types of cell death that can be found after in vivo and in vitro exposure to these metals." | ( García-Fernández, AJ; Gómez-Ramírez, P; Hernández-García, A; María-Mojica, P; Martínez-López, E; Romero, D, 2014) |
| "Osteonecrosis is a major glucocorticoid-induced complication in the orthopedics field." | ( Ichiseki, T; Kaneuji, A; Matsumoto, T; Ueda, S; Ueda, Y; Yonekura, H; Yoshitomi, Y, 2015) |
| "Treatment induced necrosis is a relatively frequent finding in patients treated for high-grade glioma." | ( Alexiou, GA; Argyropoulou, MI; Fotopoulos, AD; Goussia, A; Kosta, P; Kyritsis, AP; Papadopoulos, A; Tsekeris, P; Tsiouris, S; Voulgaris, S; Zikou, A, 2014) |
| "Calcific myonecrosis is a rare condition in which muscle in a limb compartment undergoes necrosis and becomes peripherally calcified with central liquefaction." | ( Kanjanapradit, K; Laohawiriyakamol, T; Suwanno, P; Tanutit, P; Yuenyongviwat, V, 2014) |
| "Wound necrosis is a potentially devastating complication of complex knee reconstruction." | ( Jacobson, SR; Sierra, RJ; Taunton, MJ; Tran, NV; Trousdale, RT; Wyles, CC, 2015) |
| "Wheat hybrid necrosis is an interesting genetic phenomenon that is found frequently and results in gradual death or loss of productivity of wheat." | ( Cheng, Y; Deng, K; Guo, J; Liu, C; Yang, E; Zhang, Y; Zheng, X; Zhou, J, 2014) |
| "Systemic necrosis is one of the most severe symptoms caused by plant RNA viruses." | ( Hashimoto, M; Ishikawa, K; Iwai, R; Keima, T; Kitazawa, Y; Komatsu, K; Maejima, K; Namba, S; Okano, Y; Shiraishi, T; Yamaji, Y; Yoshida, T, 2015) |
| "Conduit necrosis is a rare but potentially devastating complication of oesophageal surgery and the subsequent reversal of oesophageal discontinuity can be challenging." | ( Cooke, DT; Pu, LL; Xu, H; Yin, K, 2015) |
| "Scalp necrosis is an important sign that should prompt those approached by these patients to consider GCA." | ( Palmer, VE; Vusirikala, B; Young-Zvandasara, T, 2015) |
| "Injection-induced necrosis is a rare but dreaded consequence of soft tissue augmentation with filler agents." | ( Biesman, BS; Cohen, JL; Dayan, SH; DeLorenzi, C; Lambros, VS; Nestor, MS; Sadick, N; Sykes, J, 2015) |
| "Mastectomy flap necrosis is a common complication of immediate breast reconstruction that impacts recovery time and reconstructive success." | ( Bahng, S; Bovill, E; Brasher, P; Gdalevitch, P; Ho, A; Lennox, P; Macadam, S; Van Laeken, N, 2015) |
| "Necrosis is one of the main forms of cardiomyocyte death in heart disease." | ( Feng, C; Gong, Y; Jiao, JQ; Li, PF; Li, Q; Liu, J; Teng, S; Wang, JL; Wang, JX; Wang, K; Wang, Y; Zhang, XJ; Zhou, LY; Zhou, ZX, 2015) |
| "Necrosis is depicted by a gain in cell volume (oncosis), swelling of organelles, plasma membrane leakage, and subsequent loss of intracellular contents." | ( Casanelles, E; Garcia-Belinchón, M; Granados-Colomina, C; Iglesias-Guimarais, V; Martínez-Escardó, L; Pascual-Guiral, S; Ribas, J; Sánchez-Osuna, M; Yuste, VJ, 2015) |
| "Troxis necrosis is a novel mechanism for drug-induced hepatitis, including immunomodulatory medications including a monoclonal anti-TWEAK antibody and Cellcept and Plaquenil, two widely used immunosuppression/anti-rejection medications." | ( Datta, A; Fleishman, W; French, SW; Karpouzas, G; Penunuri, A; Wei, CH, 2015) |
| "Necrosis is programmed and is one of the main forms of cell death in the pathological process in cardiac diseases." | ( Dong, YH; Gao, JN; Li, L; Li, N; Li, PF; Liu, CY; Long, B; Wang, CQ; Wang, K; Zhou, LY, 2016) |
| "Tumor necrosis is one of the indicators of tumor aggressiveness." | ( Hatanaka, KC; Hirata, K; Kobayashi, H; Kobayashi, K; Kuge, Y; Manabe, O; Shiga, T; Tamaki, N; Terasaka, S; Toyonaga, T; Watanabe, S; Yamaguchi, S; Yuzawa, S, 2016) |
| "Programmed necrosis is established as a new form of programmed cell death and is emerging as a new strategy of treatment for cancers." | ( Chi, G; Ge, P; Jin, Y; Liu, K; Lu, B; Luo, T; Luo, Y; Wang, C; Wang, Z; Zhao, H; Zheng, L; Zhou, Z; Zhu, D, 2016) |
| "Skin necrosis is due to a transient hypercoagulable state during the initiation of vitamin K antagonist treatment due to an imbalance between pro- and anticoagulant factors." | ( Closs-Prophette, F; Maillard, H; Osmaeva, K; Vildy, S, 2017) |
| "Mastectomy flap necrosis is a major complication in patients undergoing tissue expander-based reconstruction." | ( Choudry, U; Cunningham, BL; Diep, GK; Hui, JY; Marmor, S; Portschy, PR; Tuttle, TM, 2016) |
| "Necrosis is one of the main forms of cardiomyocyte death in heart disease." | ( Chen, Q; Chen, X; Dong, Z; Du, Y; Han, C; Huang, T; Wang, Y, 2016) |
| "Necrosis is a hallmark of several widespread diseases or their direct complications." | ( Linkermann, A; Tonnus, W, 2017) |
| "Radiation necrosis is one of the complications of Gammaknife radiosurgery." | ( Feng, Y; Ma, Y; Xu, Q; Zheng, C, 2017) |
| "Secondary burn necrosis is the expansion and deepening of the original burn injury several days after injury." | ( Butler, KL; Chang, P; Chico Calero, I; Goverman, J; Inoue, Y; Irimia, D; Liu, YM; Nazarian, RM; Otawara, M; Stephanie Nam, A; Vakoc, BJ; Yu, YM, 2018) |
| "Uvular necrosis is an extremely rare complication of gastroscopy." | ( Digby-Bell, J; Zeki, S, 2017) |
| "Intranasal tissue necrosis is a previously described sequela of nasal opioid inhalation, with a similar presentation to invasive fungal rhinosinusitis (IFRS)." | ( Chowdhury, NI; DelGaudio, JM; Levy, JM; Morrison, DA; Wise, SK, 2018) |
| "Cell necrosis is thought to be the main mode of cytotoxicity based mainly on in vitro studies." | ( Ardenkjaer-Larsen, JH; Choyke, PL; Kishimoto, S; Krishna, MC; Mitchell, JB; Munasinghe, J; Oshima, N; Yamamoto, K, 2018) |
| "Necrosis is a feature of I/R lung injury." | ( Bai, XH; Keshavjee, S; Kim, H; Liu, M; Lu, C; Zamel, R, 2018) |
| "Skin flap necrosis is a serious postoperative complication." | ( Akashi, M; Arimoto, S; Hasegawa, T; Iwata, E; Komori, T; Saito, I; Sakai, Y; Sakakibara, A; Sakakibara, S; Takeda, D; Terashi, H; Ueha, T, 2018) |
| " Mastectomy flap necrosis is the source of considerable morbidity and cost following breast reconstruction." | ( Darrach, H; Han, T; Khavanin, N; Kokosis, G; Kraenzlin, F; Qiu, C; Sacks, JM, 2019) |
| "Skin necrosis is considered the most serious complication of hyaluronic acid dermal filler injection procedures." | ( Hsu, Y; Li, J; Wang, P; Wang, Y; Xu, Y, 2019) |
| "Dermal necrosis is a rare yet serious risk associated with cosmetic filler injections, and although current consensus recommends the use of hyaluronidase injections in cases of hyaluronic acid filler, the efficacy of topical nitroglycerin as a treatment has not yet been fully investigated." | ( Carley, SK; Cohen, JL; Kraus, CN, 2020) |
| "Necrosis is a form of cell death that results in rupture of the plasma membrane and the release of cellular contents, and it can give rise to sterile inflammation in the retina and other tissues." | ( Hatano, M; Kimura, K; Kobayashi, M; Kobayashi, Y; Tokuda, K; Uchi, SH; Yamashiro, C, 2019) |
| "Calcific myonecrosis is a rare disease that has been shown to be a late sequela of trauma." | ( Angelini, A; Cappellesso, R; Fanelli, GN; Mavrogenis, AF; Pagliarini, E; Ruggieri, P; Trovarelli, G, 2019) |
| "Scalp necrosis is a known ischemic complication of GCA with approximately 100 cases reported in the literature to date." | ( Al Othman, B; Kini, T; Lee, AG; Somani, AN, 2021) |
| "Necrosis is a pathological form of cell death that induces an inflammatory response, and immune cell activation contributes to the development and maintenance of hypertension." | ( Abdelbary, M; Baban, B; Brands, MW; Gillis, EE; Musall, JB; O'Connor, PM; Rafikova, O; Sullivan, JC, 2019) |
| "Scalp necrosis is a rare, potentially life-threatening complication of giant cell arteritis." | ( Baker, G; Kerr, O; McDonald, L, 2019) |
| "Random-pattern flap necrosis is a serious challenge for plastic surgeons." | ( Gao, W; Huang, Z; Jiang, C; Jiang, R; Lin, C; Lin, D, 2020) |
| "Flap necrosis is a common complication after mastectomy, and nitroglycerin (NTG) ointment has been used successfully to treat it." | ( Gu, L; Ma, J; Qin, Z; Wang, P; Wang, Q, 2020) |
| "Skin necrosis is a known postoperative complication of mastectomies." | ( Lara, D; Lu, C; Marano, A; Otterburn, DM; Samadi, A; Van, YR; Wald, G; Wright, M, 2020) |
| "Recipient site necrosis is a rare but potentially devastating complication of hair restoration surgery." | ( Abbas, Z; Kufi, H, 2021) |
| "Scalp necrosis is very rare due to its rich vascularity." | ( Akbarzadeh, K; Esmaeili Zabihi, R; Hajmohammadi, K; Parizad, N, 2020) |
| "Shoot tip necrosis is a physiological condition that negatively impacts the growth and development of in vitro plant shoot cultures across a wide range of species." | ( Barreal, ME; Dobránszki, J; Driver, JA; Gallego, PP; Gulyás, A; Hidvégi, N; Kher, MM; Landín, M; Magyar-Tábori, K; Márton, L; Mendler-Drienyovszki, N; Nezami-Alanagh, E; Teixeira da Silva, JA; Wicaksono, A, 2020) |
| "Cutaneous necrosis is one of its rare clinical features." | ( Cheng, D; Jiang, Q; Niu, N; Wang, Z, 2020) |
| "Vaginal necrosis is a late radiation tissue injury with serious morbidity complications." | ( Jia, AY; Viswanathan, AN, 2021) |
| "Acinar cell necrosis is one of the most prominent pathophysiological changes of acute pancreatitis (AP)." | ( Ding, Y; Gong, W; Hu, L; Liu, X; Lu, G; Shi, X; Wu, K; Yang, Q; Yao, G; Zhang, H; Zhu, Q, 2021) |
| "Plaque necrosis is a key feature of defective resolution in atherosclerosis." | ( Adam, AP; Bossardi Ramos, R; Decker, C; Fredman, G; Gerlach, BD; Hosseini, Z; Marinello, M; Sadhu, S; Sansbury, BE; Spite, M, 2021) |
| "Necrosis is the main mode of cell death, which leads to multiple clinical conditions affecting hundreds of millions of people worldwide." | ( Albeck, A; Khalfin, B; Lichtenstein, A; Nathan, I, 2021) |
| "Excitotoxic necrosis is a leading form of neurodegeneration." | ( Idrizi, A; Mano, I; Mendelowitz, ZZ, 2021) |
| "Skin necrosis is one of the most severe complications following filler injections, and can result in permanent aesthetic defects." | ( Ahn, GR; Choi, SY; Kim, BJ; Li, K; Park, JW; Park, SJ; Yoo, KH, 2021) |
| "Scleral necrosis is a potential complication of subconjunctival triamcinolone acetate." | ( Agarwal, R; Bafna, RK; Chetan, C; Sharma, N, 2021) |
| "Flap necrosis is a feared complication of reconstructive surgery." | ( Fleming, JC; Hartman Bs, YE; Hicks, MD; Mansur, A; Ovaitt, AK; Rosenthal, EL; Song, PN; Sorace, AG; Thomas, CM; Warram, JM, 2022) |
| "We now know that necrosis is controlled by multiple pathways in response to many different cellular conditions." | ( Crook, M; Detwiler, AC; Hanna-Rose, W; Reza, RN; Serra, ND, 2022) |
| "Necrosis is one of the methods of programmed cell death and cardiomyocyte necrosis occurs in the process of reperfusion." | ( Chen, R; Shao, C; Wang, Z; Xu, Y; Yan, J; Zang, G, 2022) |
| "Ischemic skin necrosis is a rare and serious adverse effect of terlipressin." | ( Song, L; Wang, C; Zeng, J; Zhou, Y, 2022) |
| "Tissue necrosis is a serious but rare complication of sclerotherapy." | ( Connor, D; Hannaford, P; Kang, M; Parsi, K; Yang, A, 2022) |
| "Necrosis is a rare yet devastating complication of soft tissue fillers." | ( Clarey, D; Glenn, EJ; Rentfro, K; Sulewski, R; Wysong, A, 2022) |
| "Scalp necrosis is a rare complication of giant cell arteritis (GCA); however, it is a predictor of severe disease." | ( Kosaka, S; Nakamura, K; Nawata, A; Nawata, M; Saito, K; Tanaka, Y; Yamazumi, K, 2023) |
| "Intestinal necrosis is a frequent complication in patients with incarcerated femoral hernias (IFH)." | ( Beji, H; Bouassida, M; Chtourou, MF; Kallel, Y; Laamiri, G; Mighri, MM; Mroua, B; Touinsi, H; Zribi, S, 2023) |