beta-hydroxyethoxyacetic acid profile

Beta-hydroxyethoxyacetic acid, also known as hydroxyethoxyacetic acid or HEAA, is a chemical compound that is used as an intermediate in the synthesis of various pharmaceuticals and other chemical products. It is a colorless liquid with a mild odor. HEAA is used in the production of a variety of pharmaceutical intermediates, such as the anti-inflammatory drug ibuprofen and the anti-viral drug acyclovir. It is also used in the synthesis of agricultural chemicals, such as herbicides and insecticides. HEAA is a versatile chemical intermediate that is used in the production of a wide range of products. Its importance stems from its ability to undergo various chemical reactions, making it suitable for the synthesis of a wide variety of compounds.'

beta-hydroxyethoxyacetic acid: metabolite of both dioxane and diethylene glycol [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	25935
CHEMBL ID	147714
SCHEMBL ID	766381
MeSH ID	M0071032

Synonym
beta-hydroxyethoxyacetic acid
AKOS000221081
CHEMBL147714
2-(2-hydroxyethoxy)acetic acid
13382-47-3
unii-6kg0t74lyt
6kg0t74lyt ,
(2-hydroxyethoxy)acetic acid
VKC ,
2-hydroxyethoxyacetic acid
SCHEMBL766381
DTXSID70158385
acetic acid, (2-hydroxyethoxy)-
BP-23710
BP-23709
ho-peg-ch2cooh, mw 5,000
ho-peg-ch2cooh, mw 3,400
AS-61030
(2-hydroxyethoxy)acetate
VDNMIIDPBBCMTM-UHFFFAOYSA-N
Q27265051
BP-26032
BP-25218
ho-peg-ch2cooh, mw 2,000
ho-peg-ch2cooh, mw 10,000
BP-25216
hydroxyl peg acetic acid,mw 10k
CS-0145955
HY-134611

Excerpt	Reference	Relevance
" Oral doses were well absorbed and excreted primarily (approximately 80%) in urine within 24 hr of administration."	( Metabolism and disposition of diethylene glycol in rat and dog. Mathews, JM; Matthews, HB; Parker, MK, )	0.13

Assay ID	Title	Year	Journal	Article
AID21764	Solubility was measured in saline at 25 degree C	2003	Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23	Poly(ethylene glycol) transport forms of vancomycin: a long-lived continuous release delivery system.
AID12706	Half-life in rat plasma	2003	Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23	Poly(ethylene glycol) transport forms of vancomycin: a long-lived continuous release delivery system.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (22.22)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (22.22)	29.6817
2010's	4 (44.44)	24.3611
2020's	1 (11.11)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
formic acid formic acid: RN given refers to parent cpd. formic acid : The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects.	2.11	1	monocarboxylic acid	antibacterial agent; astringent; metabolite; protic solvent; solvent
glycolic acid glycolic acid: RN given refers to parent cpd. glycolic acid : A 2-hydroxy monocarboxylic acid that is acetic acid where the methyl group has been hydroxylated.	2.11	1	2-hydroxy monocarboxylic acid; primary alcohol	keratolytic drug; metabolite
fomepizole Fomepizole: A pyrazole and competitive inhibitor of ALCOHOL DEHYDROGENASE that is used for the treatment of poisoning by ETHYLENE GLYCOL or METHANOL.. fomepizole : A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4.	2.08	1	pyrazoles	antidote; EC 1.1.1.1 (alcohol dehydrogenase) inhibitor; protective agent
diglycolic acid diglycolic acid: nephrotoxic metabolite in diethylene glycol poisoning inducing necrosis in human proximal tubule cells	2.8	3	dicarboxylic acid
diethylene glycol glycol ether : A hydroxyether which contains both an ether and alcohol functional groups. It is one of the most versatile classes of organic solvents which are commonly used in paints, cleaners, adhesives, pharmaceuticals and cosmetics.	2.8	3	hydroxyether
methoxyacetic acid methoxyacetic acid: RN given refers to parent cpd. methoxyacetic acid : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a methoxy group.	2.11	1	ether; monocarboxylic acid	antineoplastic agent; apoptosis inducer; human xenobiotic metabolite; mutagen
ethoxyacetic acid [no description available]	2.11	1	carboxylic acid
vancomycin Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.	2.01	1	glycopeptide	antibacterial drug; antimicrobial agent; bacterial metabolite
phenyl acetate phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.	3.52	8	benzenes; phenyl acetates
1,4-dioxane 1,4-dioxane: dehydrating agent; polar solvent miscible both with water & most organic solvents. dioxane : Any member of the class of dioxanes that is a cyclohexane in which two carbon atoms are replaced by oxygen atoms.. 1,4-dioxane : A dioxane with oxygen atoms at positions 1 and 4.	2.46	2	dioxane; volatile organic compound	carcinogenic agent; metabolite; NMR chemical shift reference compound; non-polar solvent

Condition	Relationship Strength	Studies
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.08	1
Encephalopathy, Toxic [description not available]	2.08	1
Poisoning Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.	2.08	1
Metabolic Acidosis [description not available]	2.11	1
Alcoholic Intoxication An acute brain syndrome which results from the excessive ingestion of ETHANOL or ALCOHOLIC BEVERAGES.	2.11	1
Acidosis A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.	2.11	1
Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.	2.06	1

beta-hydroxyethoxyacetic acid

Description

Cross-References

Synonyms (29)

Research Excerpts

Bioavailability

Bioassays (2)

Research

Studies (9)

Market Indicators

Research Demand Index: 12.27

Study Types