isopryn, phenylbutazone drug combination profile

ID Source	ID
PubMed CID	6441309
MeSH ID	M0044658

Synonym
tomanil
tomanol
isopryn - phenybutazone
isopryn, phenylbutazone drug combination
3,5-pyrazolidinedione, 4-butyl-1,2-diphenyl-, mixt. with (e)-1-(4-((6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranosyl)oxy)-2-hydroxy-6-methoxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)-2-propen-1-one and 1,2-dihydro-1,5-dimethyl-4-((1-methylethyl)amin
8058-14-8
4-butyl-1,2-diphenylpyrazolidine-3,5-dione;1,5-dimethyl-2-phenyl-4-(propan-2-ylamino)pyrazol-3-one;(e)-3-(3-hydroxy-4-methoxyphenyl)-1-[2-hydroxy-6-methoxy-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-[[(2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymet

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	18 (100.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	1 (5.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	19 (95.00%)	84.16%

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	pre-1990
pyrazole	2	pyrazole		1961	1962	62.5	low	2
antipyrine	5	pyrazolone	antipyretic; cyclooxygenase 3 inhibitor; environmental contaminant; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic	1959	1964	63.0	medium	5
kebuzone	1	methyl ketone; pyrazolidines	non-narcotic analgesic; non-steroidal anti-inflammatory drug	1983	1983	41.0	low	1
phenylbutazone	18	pyrazolidines	antirheumatic drug; EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor; metabolite; non-narcotic analgesic; non-steroidal anti-inflammatory drug; peripheral nervous system drug	1959	1988	52.7	high	18
ramifenazone	1	pyrazoles; ring assembly		1985	1985	39.0	low	1
penicillin g	1	penicillin allergen; penicillin	antibacterial drug; drug allergen; epitope	1982	1982	42.0	low	1
aminopyrine	2	pyrazolone; tertiary amino compound	antipyretic; environmental contaminant; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic	1964	1985	49.5	low	2
triamcinolone acetonide	1	11beta-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; cyclic ketal; fluorinated steroid; glucocorticoid; primary alpha-hydroxy ketone	anti-allergic agent; anti-inflammatory drug	1988	1988	36.0	low	1
dipyrone	1	organic sodium salt	anti-inflammatory agent; antipyretic; antirheumatic drug; cyclooxygenase 3 inhibitor; non-narcotic analgesic; peripheral nervous system drug; prodrug	1985	1985	39.0	low	1
butylscopolammonium bromide	1			1985	1985	39.0	low	1
pyrazolone	1			1959	1959	65.0	low	1
phenylbutazone, propyphenazone drug combination	1			1964	1964	60.0	low	1

Condition	Studies	First Year	Last Year	Average Age	Relationship Strength	pre-1990
Abdominal Migraine	3	1983	1985	40.0	low	3
Acute Hypercapnic Respiratory Failure	1	1964	1964	60.0	low	1
Acute Liver Injury, Drug-Induced	1	1964	1964	60.0	low	1
Anasarca	1	1960	1960	64.0	low	1
Arthritis	1	1964	1964	60.0	low	1
Arthritis, Degenerative	1	1964	1964	60.0	low	1
Arthritis, Rheumatoid	1	1964	1964	60.0	low	1
Arthropathies	1	1964	1964	60.0	low	1
Atrophy, Muscle	1	1988	1988	36.0	low	1
Bilirubinemia	1	1964	1964	60.0	low	1
Chemical and Drug Induced Liver Injury	1	1964	1964	60.0	low	1
Collagen Diseases	1	1962	1962	62.0	low	1
Disc, Herniated	1	1964	1964	60.0	low	1
Disease	1	1960	1960	64.0	low	1
Edema	1	1960	1960	64.0	low	1
Emesis	1	1964	1964	60.0	low	1
Equine Diseases	1	1985	1985	39.0	low	1
Hepatitis	1	1964	1964	60.0	low	1
Icterus	1	1964	1964	60.0	low	1
Incontinentia Pigmenti Achromians	1	1988	1988	36.0	low	1
Intervertebral Disc Displacement	1	1964	1964	60.0	low	1
Jaundice	1	1964	1964	60.0	low	1
Joint Diseases	1	1964	1964	60.0	low	1
Mastitis, Bovine	1	1979	1979	45.0	low	1
Migraine Disorders	3	1983	1985	40.0	low	3
Muscular Atrophy	1	1988	1988	36.0	low	1
Nausea	1	1964	1964	60.0	low	1
Necrosis	1	1983	1983	41.0	low	1
Osteoarthritis	1	1964	1964	60.0	low	1
Periarthritis	1	1960	1960	64.0	low	1
Peripheral Nerve Diseases	1	1988	1988	36.0	low	1
Peripheral Nervous System Diseases	1	1988	1988	36.0	low	1
Polyarthritis	1	1964	1964	60.0	low	1
Proteinuria	1	1964	1964	60.0	low	1
Respiratory Insufficiency	1	1964	1964	60.0	low	1
Rheumatic Diseases	5	1959	1964	62.4	low	5
Rheumatism	5	1959	1964	62.4	low	5
Rheumatoid Arthritis	1	1964	1964	60.0	low	1
Vomiting	1	1964	1964	60.0	low	1

[TOMANOL THERAPY OF INFLAMMATORY AND OTHER FORMS OF RHEUMATISM].
Srpski arhiv za celokupno lekarstvo, , Volume: 92, 1964

[TOMANOL THERAPY OF INFLAMMATORY AND OTHER FORMS OF RHEUMATISM].
Srpski arhiv za celokupno lekarstvo, , Volume: 92, 1964

[Study of lysozyme in the blood, urine and synovial fluid in different stages of rheumatoid polyarthritis and under the influence of therapy].
Medecine interne, , Volume: 19, Issue:1

[The treatment of rheumatic and related diseases in general practice with a combined pyrazole preparation (Tomanol)].
Die Medizinische Welt, , Aug-18, Volume: 33, 1962

[Experiences with tomanol in the therapy of rheumatic disorders and postoperative edema].
Medizinische Klinik, , Jul-15, Volume: 55, 1960

[3 CASES OF POISONING IN CHILDHOOD WITH IRGAPYRIN, BUTAZOLIDIN AND TOMANOL].
Annales paediatrici. International review of pediatrics, , Volume: 202, 1964

[THE TREATMENT OF INFLAMMATORY AND OTHER FORMS OF RHEUMATISM WITH TOMANOL].
Die Medizinische Welt, , May-30, Volume: 22, 1964

[3 CASES OF POISONING IN CHILDHOOD WITH IRGAPYRIN, BUTAZOLIDIN AND TOMANOL].
Annales paediatrici. International review of pediatrics, , Volume: 202, 1964

[THE TREATMENT OF INFLAMMATORY AND OTHER FORMS OF RHEUMATISM WITH TOMANOL].
Die Medizinische Welt, , May-30, Volume: 22, 1964

Isopyrin-phenylbutazone for intractable migraine.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, , Jan-19, Volume: 67, Issue:3, 1985

Isopyrine-phenylbutazone for intractable migraine.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, , Sep-01, Volume: 66, Issue:9, 1984

Migraine headache:--the prophylactic role of an isopyrin-phebuzine compound (Tomanol).
The Central African journal of medicine, , Volume: 29, Issue:10, 1983

Some pertinent case reports.
Australian family physician, , Volume: 17, Issue:7, 1988

[3 CASES OF POISONING IN CHILDHOOD WITH IRGAPYRIN, BUTAZOLIDIN AND TOMANOL].
Annales paediatrici. International review of pediatrics, , Volume: 202, 1964

[Damage to skeletal muscles by intramuscular administration of anti-inflammatory agents of the pyrazolidine type].
Sbornik lekarsky, , Volume: 85, Issue:6, 1983

[THE TREATMENT OF INFLAMMATORY AND OTHER FORMS OF RHEUMATISM WITH TOMANOL].
Die Medizinische Welt, , May-30, Volume: 22, 1964

[Effect of Tomanol on the analgesic requirements and digestive transit in the postoperative course].
Revista de chirurgie, oncologie, radiologie, o.r.l., oftalmologie, stomatologie. Chirurgie, , Volume: 36, Issue:1

[Therapy of humeroscapular periarthritis with tomanol].
Medizinische Klinik, , Jan-15, Volume: 55, 1960

Some pertinent case reports.
Australian family physician, , Volume: 17, Issue:7, 1988

[3 CASES OF POISONING IN CHILDHOOD WITH IRGAPYRIN, BUTAZOLIDIN AND TOMANOL].
Annales paediatrici. International review of pediatrics, , Volume: 202, 1964

[THE TREATMENT OF INFLAMMATORY AND OTHER FORMS OF RHEUMATISM WITH TOMANOL].
Die Medizinische Welt, , May-30, Volume: 22, 1964

[TOMANOL THERAPY OF INFLAMMATORY AND OTHER FORMS OF RHEUMATISM].
Srpski arhiv za celokupno lekarstvo, , Volume: 92, 1964

[Clinical experiences with the new antirheumatic drug Tomanol].
Die Medizinische Welt, , Jun-17, Volume: 24, 1961

[Experiences with tomanol in the therapy of rheumatic disorders and postoperative edema].
Medizinische Klinik, , Jul-15, Volume: 55, 1960

[Therapy of rheumatism with tomanol, a new pyrazolone-pyrazolidine preparation].
Munchener medizinische Wochenschrift (1950), , Oct-02, Volume: 101, 1959

[3 CASES OF POISONING IN CHILDHOOD WITH IRGAPYRIN, BUTAZOLIDIN AND TOMANOL].
Annales paediatrici. International review of pediatrics, , Volume: 202, 1964

[TOMANOL THERAPY OF INFLAMMATORY AND OTHER FORMS OF RHEUMATISM].
Srpski arhiv za celokupno lekarstvo, , Volume: 92, 1964

[TOMANOL THERAPY OF INFLAMMATORY AND OTHER FORMS OF RHEUMATISM].
Srpski arhiv za celokupno lekarstvo, , Volume: 92, 1964

[Study of lysozyme in the blood, urine and synovial fluid in different stages of rheumatoid polyarthritis and under the influence of therapy].
Medecine interne, , Volume: 19, Issue:1

[Therapy of humeroscapular periarthritis with tomanol].
Medizinische Klinik, , Jan-15, Volume: 55, 1960

[Experiences with tomanol in the therapy of rheumatic disorders and postoperative edema].
Medizinische Klinik, , Jul-15, Volume: 55, 1960

Suspected non-steroidal anti-inflammatory drug toxicity in a horse.
The Veterinary record, , Nov-30, Volume: 117, Issue:22, 1985

[3 CASES OF POISONING IN CHILDHOOD WITH IRGAPYRIN, BUTAZOLIDIN AND TOMANOL].
Annales paediatrici. International review of pediatrics, , Volume: 202, 1964

[THE TREATMENT OF INFLAMMATORY AND OTHER FORMS OF RHEUMATISM WITH TOMANOL].
Die Medizinische Welt, , May-30, Volume: 22, 1964

[3 CASES OF POISONING IN CHILDHOOD WITH IRGAPYRIN, BUTAZOLIDIN AND TOMANOL].
Annales paediatrici. International review of pediatrics, , Volume: 202, 1964

[THE TREATMENT OF INFLAMMATORY AND OTHER FORMS OF RHEUMATISM WITH TOMANOL].
Die Medizinische Welt, , May-30, Volume: 22, 1964

[Double blind study on the effectiveness of an additional therapy with Tomanol in acute mastitis of cattle (author's transl)].
DTW. Deutsche tierarztliche Wochenschrift, , Volume: 86, Issue:12, 1979

Isopyrin-phenylbutazone for intractable migraine.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, , Jan-19, Volume: 67, Issue:3, 1985

Isopyrine-phenylbutazone for intractable migraine.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, , Sep-01, Volume: 66, Issue:9, 1984

Migraine headache:--the prophylactic role of an isopyrin-phebuzine compound (Tomanol).
The Central African journal of medicine, , Volume: 29, Issue:10, 1983

Some pertinent case reports.
Australian family physician, , Volume: 17, Issue:7, 1988

[THE TREATMENT OF INFLAMMATORY AND OTHER FORMS OF RHEUMATISM WITH TOMANOL].
Die Medizinische Welt, , May-30, Volume: 22, 1964

[Effect of Tomanol on the analgesic requirements and digestive transit in the postoperative course].
Revista de chirurgie, oncologie, radiologie, o.r.l., oftalmologie, stomatologie. Chirurgie, , Volume: 36, Issue:1

Some pertinent case reports.
Australian family physician, , Volume: 17, Issue:7, 1988

[3 CASES OF POISONING IN CHILDHOOD WITH IRGAPYRIN, BUTAZOLIDIN AND TOMANOL].
Annales paediatrici. International review of pediatrics, , Volume: 202, 1964

[TOMANOL THERAPY OF INFLAMMATORY AND OTHER FORMS OF RHEUMATISM].
Srpski arhiv za celokupno lekarstvo, , Volume: 92, 1964

[THE TREATMENT OF INFLAMMATORY AND OTHER FORMS OF RHEUMATISM WITH TOMANOL].
Die Medizinische Welt, , May-30, Volume: 22, 1964

[Clinical experiences with the new antirheumatic drug Tomanol].
Die Medizinische Welt, , Jun-17, Volume: 24, 1961

[Experiences with tomanol in the therapy of rheumatic disorders and postoperative edema].
Medizinische Klinik, , Jul-15, Volume: 55, 1960

[Therapy of rheumatism with tomanol, a new pyrazolone-pyrazolidine preparation].
Munchener medizinische Wochenschrift (1950), , Oct-02, Volume: 101, 1959

[3 CASES OF POISONING IN CHILDHOOD WITH IRGAPYRIN, BUTAZOLIDIN AND TOMANOL].
Annales paediatrici. International review of pediatrics, , Volume: 202, 1964

isopryn, phenylbutazone drug combination

Description

Cross-References

Synonyms (7)

Research

Studies (18)

Study Types

Pharmacokinetics (1)

isopryn, phenylbutazone drug combination

Description

Cross-References

Synonyms (7)

Research

Studies (18)

Study Types

Related Drugs (12)

Drugs Researched Together (12)

Related Conditions (39)

Pharmacokinetics (1)