s-(3-hydroxypropyl)cysteine n-acetate profile

ID Source	ID
PubMed CID	119083
CHEBI ID	165884
MeSH ID	M0041615

Synonym
3-hydroxypropylmercapturic acid
23127-40-4
n-acetyl-s- (3-hydroxypropyl)-cysteine
CHEBI:165884
(2r)-2-acetamido-3-(3-hydroxypropylsulanyl)propanoic acid
l-cysteine, n-acetyl-s-(3-hydroxypropyl)-
(2r)-2-acetamido-3-(3-hydroxypropylsulfanyl)propanoic acid
unii-bfu3149v95
2-acetamido-3-(3'-hydroxypropylthio)propanoic acid
n-acetyl-s-(3-hydroxypropyl)-l-cysteine
bfu3149v95 ,
s-(3-hydroxypropyl)cysteine n-acetate
n-acetyl-s-(3-hydroxypropyl)cysteine
3-(n-acetyl-l-cystein-s-yl)propan-1-ol
s-(3-hydroxypropyl)mercapturic acid
3-(hydroxypropyl)mercapturic acid
alanine, n-acetyl-3-((3-hydroxypropyl)thio)-, l-
n -acetyl-s-(3-hydroxypropyl)-l-cysteine
n-acetyl-s- (3-hydroxypropyl)-l-cysteine
DTXSID30904325
(r)-2-acetamido-3-((3-hydroxypropyl)thio)propanoic acid
Q27274648
discontinued see: a179075
discontinued see a179070
also see a179075
(r)-2-acetamido-3-((3-hydroxypropyl)thio)propanoicacid
PD156164

Excerpt	Reference	Relevance
" When dosed at quantities limited by toxicity, allyl acetate and allyl alcohol produce higher levels of urinary mercapturic acids than the minimally toxic dose of acrolein."	( A comparative 90-day toxicity study of allyl acetate, allyl alcohol and acrolein. Auerbach, SS; Irwin, RD; Mahler, J; Travlos, GS, 2008)	0.35
" However, cyclophosphamide may lead to toxic side effects on the bladder, namely hemorrhagic cystitis, which can cause hematuria, and, potentially, bladder cancer."	( Quantification of 3-Hydroxypropyl Mercapturic Acid in the Urine of Patients with Breast Cancer to Monitor Cyclophosphamide Toxicity. Harahap, Y; Melhan, M; Muhammad, C; Purwanto, DJ; Yanuar, A, 2020)	0.56

Excerpt	Relevance	Reference
" Rats (10/group) were dosed with 0-100mg/kg allyl acetate, 0-25mg/kg allyl alcohol, or 0-10mg/kg acrolein."	( A comparative 90-day toxicity study of allyl acetate, allyl alcohol and acrolein. Auerbach, SS; Irwin, RD; Mahler, J; Travlos, GS, 2008)	0.35
"6) were positively associated with the 3-HPMA, CEMA and ∑Acrolein with evidence of a dose-response relationship (p<0."	( Acrolein metabolites, diabetes and insulin resistance. Attanasio, R; Feroe, AG; Scinicariello, F, 2016)	0.43

Class	Description
N-acyl-L-amino acid	Any N-acylamino acid having L-configuration.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (5.56)	18.7374
1990's	3 (8.33)	18.2507
2000's	4 (11.11)	29.6817
2010's	24 (66.67)	24.3611
2020's	3 (8.33)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (2.78%)	5.53%
Reviews	1 (2.78%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	34 (94.44%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
benzene [no description available]	2.11	1	0	aromatic annulene; benzenes; volatile organic compound	carcinogenic agent; environmental contaminant; non-polar solvent
carbon monoxide Carbon Monoxide: Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed). carbon monoxide : A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.	4.85	2	1	carbon oxide; gas molecular entity; one-carbon compound	biomarker; EC 1.9.3.1 (cytochrome c oxidase) inhibitor; human metabolite; ligand; metabolite; mitochondrial respiratory-chain inhibitor; mouse metabolite; neurotoxin; neurotransmitter; P450 inhibitor; probe; signalling molecule; vasodilator agent
formic acid formic acid: RN given refers to parent cpd. formic acid : The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects.	2.17	1	0	monocarboxylic acid	antibacterial agent; astringent; metabolite; protic solvent; solvent
formaldehyde paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy	2.17	1	0	aldehyde; one-carbon compound	allergen; carcinogenic agent; disinfectant; EC 3.5.1.4 (amidase) inhibitor; environmental contaminant; Escherichia coli metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
hydralazine Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.. hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.	2.11	1	0	azaarene; hydrazines; ortho-fused heteroarene; phthalazines	antihypertensive agent; vasodilator agent
propane Propane: A three carbon alkane with the formula H3CCH2CH3.	1.95	1	0	alkane; gas molecular entity	food propellant
propylene dichloride propylene dichloride: Russian drug; structure. 1,2-dichloropropane : A chloroalkane that is propane in which a hydrogen from each of two adjacent carbons has been replaced by chlorines.	1.95	1	0	chloroalkane; volatile organic compound
acrolein [no description available]	5.73	24	0	enal	herbicide; human xenobiotic metabolite; toxin
allyl chloride [no description available]	1.99	1	0	organochlorine compound
acrylonitrile [no description available]	2.52	2	0	aliphatic nitrile; volatile organic compound	antifungal agent; carcinogenic agent; fungal metabolite; mutagen; polar aprotic solvent
allyl alcohol allyl alcohol: structure. allylic alcohol : An alcohol where the hydroxy group is attached to a saturated carbon atom adjacent to a double bond (R groups may be H, organyl, etc.).. allyl alcohol : A propenol in which the C=C bond connects C-2 and C-3. It is has been found in garlic (Allium sativum). Formerly used as a herbicide for the control of various grass and weed seeds.	2.04	1	0	primary allylic alcohol; propenol	antibacterial agent; fungicide; herbicide; insecticide; plant metabolite
diisopropyl ether [no description available]	1.99	1	0
allyl acetate allyl acetate: potential fumigant for treating stored grains	2.04	1	0
acetylcysteine N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.	8.38	36	1	acetylcysteine; L-cysteine derivative; N-acetyl-L-amino acid	antidote to paracetamol poisoning; antiinfective agent; antioxidant; antiviral drug; ferroptosis inhibitor; geroprotector; human metabolite; mucolytic; radical scavenger; vulnerary
1-hydroxypyrene 1-hydroxypyrene: pyrene metabolite; RN given refers to parent cpd	2.11	1	0	pyrenes
phenyl acetate phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.	2.04	1	0	benzenes; phenyl acetates
1-chloro-2-propanol 1-chloro-2-propanol: RN given refers to cpd without isomeric designation. 1-chloropropan-2-ol : A secondary alcohol that is isopropanol in which one of the methyl hydrogen atoms is substituted by chlorine.	1.95	1	0	organochlorine compound; secondary alcohol
4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone: structure; from tobacco smoke	2.1	1	0	nitrosamine; pyridines
allyl formate [no description available]	2.03	1	0
nicotine (S)-nicotine : A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.	5.67	6	1	3-(1-methylpyrrolidin-2-yl)pyridine	anxiolytic drug; biomarker; immunomodulator; mitogen; neurotoxin; nicotinic acetylcholine receptor agonist; peripheral nervous system drug; phytogenic insecticide; plant metabolite; psychotropic drug; teratogenic agent; xenobiotic
4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol 4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol: structure in first source. 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol : A member of the class of nitrosamines that is butan-1-ol substituted by a pyridin-3-yl group at position 1 and by a methyl(nitroso)amino group at position 4. It is a major metabolite of nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), which is a carcinogen found in tobacco and responsible for inducing lung cancer in smokers.	2.78	3	0	nitrosamine; pyridines; secondary alcohol	biomarker; carcinogenic agent; human urinary metabolite
s-(2-carboxyethyl)-n-acetylcysteine S-(2-carboxyethyl)-N-acetylcysteine: found in urine of patient with cystathioninuria; structure given in first source	2.43	2	0
n-acetyl-s-(2-cyanoethyl)cysteine N-acetyl-S-(2-cyanoethyl)cysteine: major urinary metabolite of acrylonitrile; structure in first source	2.52	2	0	N-acyl-L-amino acid
2-butenal crotonaldehyde : An enal consisting of propene having a formyl group at the 1-position.	2.79	3	0	enal
cotinine Cotinine: The N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It has CNS stimulating properties.. (-)-cotinine : An N-alkylpyrrolidine that consists of N-methylpyrrolidinone bearing a pyridin-3-yl substituent at position C-5 (the 5S-enantiomer). It is an alkaloid commonly found in Nicotiana tabacum.	3.22	5	0	N-alkylpyrrolidine; pyridines; pyrrolidin-2-ones; pyrrolidine alkaloid	antidepressant; biomarker; human xenobiotic metabolite; plant metabolite
s-phenyl-n-acetylcysteine S-phenyl-N-acetylcysteine: found in urine of rats exposed to benzene; RN given refers to (L)-isomer; RN for cpd without isomeric designation not available 4/88	2.73	3	0	aryl sulfide; S-substituted N-acetyl-L-cysteine	biomarker; human urinary metabolite
phenanthrenes Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.	4.48	1	1

Condition	Relationship Strength	Studies	Trials
Breast Cancer [description not available]	2.25	1	0
Hematuria Presence of blood in the urine.	2.25	1	0
Breast Neoplasms Tumors or cancer of the human BREAST.	2.25	1	0
Blast Injuries Injuries resulting when a person is struck by particles impelled with violent force from an explosion. Blast causes pulmonary concussion and hemorrhage, laceration of other thoracic and abdominal viscera, ruptured ear drums, and minor effects in the central nervous system. (From Dorland, 27th ed)	2.31	1	0
Cerebral Concussion [description not available]	2.31	1	0
Acute Brain Injuries [description not available]	2.31	1	0
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.58	2	0
Brain Concussion A nonspecific term used to describe transient alterations or loss of consciousness following closed head injuries. The duration of UNCONSCIOUSNESS generally lasts a few seconds, but may persist for several hours. Concussions may be classified as mild, intermediate, and severe. Prolonged periods of unconsciousness (often defined as greater than 6 hours in duration) may be referred to as post-traumatic coma (COMA, POST-HEAD INJURY). (From Rowland, Merritt's Textbook of Neurology, 9th ed, p418)	2.31	1	0
Brain Injuries Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.	2.31	1	0
Disease Exacerbation [description not available]	2.17	1	0
Acute Confusional Senile Dementia [description not available]	2.54	2	0
Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	2.54	2	0
Drug Withdrawal Symptoms [description not available]	4.88	2	1
Substance Withdrawal Syndrome Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.	4.88	2	1
Nicotine Addiction [description not available]	4.48	1	1
Tobacco Use Disorder Tobacco used to the detriment of a person's health or social functioning. Tobacco dependence is included.	4.48	1	1
Smoking Cessation Discontinuing the habit of SMOKING.	4.85	2	1
Cardiovascular Diseases Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.	2.1	1	0
Cognitive Decline [description not available]	2.11	1	0
Cognitive Dysfunction Diminished or impaired mental and/or intellectual function.	2.11	1	0
Cancer of Lung [description not available]	2.52	2	0
Lung Neoplasms Tumors or cancer of the LUNG.	2.52	2	0
Allodynia [description not available]	2.11	1	0
Nerve Pain [description not available]	2.11	1	0
Injuries, Spinal Cord [description not available]	2.53	2	0
Neuralgia Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.	2.11	1	0
Spinal Cord Injuries Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).	2.53	2	0
Diabetes Mellitus, Adult-Onset [description not available]	2.13	1	0
Insulin Sensitivity [description not available]	2.13	1	0
Diabetes Mellitus, Type 2 A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.	2.13	1	0
Insulin Resistance Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.	2.13	1	0
Apoplexy [description not available]	3.42	2	0
Stroke A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)	3.42	2	0
Disc, Herniated [description not available]	2.15	1	0
Intervertebral Disc Displacement An INTERVERTEBRAL DISC in which the NUCLEUS PULPOSUS has protruded through surrounding ANNULUS FIBROSUS. This occurs most frequently in the lower lumbar region.	2.15	1	0
Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.	2.03	1	0
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2	1	0

s-(3-hydroxypropyl)cysteine n-acetate

Cross-References

Synonyms (27)

Research Excerpts

Toxicity

Dosage Studied

Drug Classes (1)

Research

Studies (36)

Market Indicators

Research Demand Index: 11.66

Study Types

s-(3-hydroxypropyl)cysteine n-acetate

Cross-References

Synonyms (27)

Research Excerpts

Toxicity

Dosage Studied

Drug Classes (1)

Research

Studies (36)

Market Indicators

Research Demand Index: 11.66

Study Types

Related Drugs (27)

Related Conditions (37)