Page last updated: 2024-08-07 16:21:37
Trypanothione reductase
[no definition available]
Synonyms
TR;
EC 1.8.1.12;
N(1),N(8)-bis(glutathionyl)spermidine reductase
Research
Bioassay Publications (18)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 9 (50.00) | 29.6817 |
| 2010's | 6 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (30)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| quinacrine | Trypanosoma cruzi | IC50 | 133.0000 | 1 | 1 |
| quinacrine | Trypanosoma cruzi | Ki | 19.0000 | 2 | 2 |
| tacrine | Trypanosoma cruzi | Ki | 140.0000 | 1 | 1 |
| chlorpromazine | Trypanosoma cruzi | IC50 | 20.6000 | 2 | 2 |
| chlorpromazine | Trypanosoma cruzi | Ki | 8.2667 | 3 | 3 |
| clomipramine | Trypanosoma cruzi | IC50 | 13.7500 | 2 | 2 |
| clomipramine | Trypanosoma cruzi | Ki | 6.6250 | 4 | 4 |
| fluphenazine | Trypanosoma cruzi | IC50 | 73.7000 | 1 | 1 |
| fluphenazine | Trypanosoma cruzi | Ki | 21.2000 | 1 | 1 |
| vitamin k 3 | Trypanosoma cruzi | IC50 | 55.0000 | 2 | 2 |
| promazine | Trypanosoma cruzi | IC50 | 108.0000 | 1 | 1 |
| promazine | Trypanosoma cruzi | Ki | 59.1000 | 1 | 1 |
| promethazine | Trypanosoma cruzi | IC50 | 271.0000 | 1 | 1 |
| promethazine | Trypanosoma cruzi | Ki | 216.0000 | 1 | 1 |
| trifluoperazine | Trypanosoma cruzi | IC50 | 72.0000 | 1 | 1 |
| trifluoperazine | Trypanosoma cruzi | Ki | 23.0000 | 1 | 1 |
| triflupromazine | Trypanosoma cruzi | IC50 | 110.0000 | 1 | 1 |
| triflupromazine | Trypanosoma cruzi | Ki | 30.2000 | 1 | 1 |
| trimeprazine | Trypanosoma cruzi | IC50 | 249.0000 | 1 | 1 |
| trimeprazine | Trypanosoma cruzi | Ki | 127.0000 | 1 | 1 |
| acepromazine | Trypanosoma cruzi | IC50 | 502.0000 | 1 | 1 |
| aminacrine | Trypanosoma cruzi | Ki | 38.0000 | 1 | 1 |
| plumbagin | Trypanosoma cruzi | IC50 | 28.0000 | 2 | 2 |
| cepharanthine | Trypanosoma cruzi | Ki | 29.6000 | 2 | 2 |
| chloracizine | Trypanosoma cruzi | IC50 | 802.0000 | 1 | 1 |
| 9-amino-6-chloro-2-methoxyacridine | Trypanosoma cruzi | Ki | 7.0000 | 1 | 1 |
| propionylpromazine | Trypanosoma cruzi | IC50 | 357.0000 | 1 | 1 |
| chlorfenethazine | Trypanosoma cruzi | IC50 | 150.0000 | 1 | 1 |
| norchlorpromazine | Trypanosoma cruzi | IC50 | 126.0000 | 1 | 1 |
| opromazine | Trypanosoma cruzi | IC50 | 76.6000 | 1 | 1 |
| didemethylchlorpromazine | Trypanosoma cruzi | IC50 | 139.0000 | 1 | 1 |
| aspidospermine | Trypanosoma cruzi | IC50 | 90.4000 | 1 | 1 |
| aspidospermine | Trypanosoma cruzi | Ki | 64.6000 | 1 | 1 |
| 2-guanidine-4-methylquinazoline | Trypanosoma cruzi | IC50 | 100.0000 | 1 | 1 |
| 2-[8-(6-amino-1H-benzimidazol-2-yl)octyl]-3H-benzimidazol-5-amine | Trypanosoma cruzi | Ki | 10.6000 | 1 | 1 |
| kukoamine a | Trypanosoma cruzi | Ki | 0.0760 | 1 | 1 |
| nifurtimox | Trypanosoma cruzi | Ki | 245.0000 | 1 | 1 |
| chlorhexidine | Trypanosoma cruzi | Ki | 2.0000 | 1 | 1 |
| 6-chlorotacrine | Trypanosoma cruzi | Ki | 80.0000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| vitamin k 3 | Trypanosoma cruzi | Km | 21.0000 | 1 | 1 |
| vitamin k 3 | Trypanosoma cruzi | x fold | 375.0000 | 1 | 1 |
| plumbagin | Trypanosoma cruzi | Km | 15.0000 | 1 | 1 |
| plumbagin | Trypanosoma cruzi | x fold | 525.0000 | 1 | 1 |
| ajoene | Trypanosoma cruzi | Km | 2,000.0000 | 2 | 2 |