Page last updated: 2024-08-07 16:21:37
Trypanothione reductase
[no definition available]
Synonyms
TR;
EC 1.8.1.12;
N(1),N(8)-bis(glutathionyl)spermidine reductase
Research
Bioassay Publications (18)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 9 (50.00) | 29.6817 |
| 2010's | 6 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (30)
Drugs with Inhibition Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| vitamin k 3 | Trypanosoma cruzi | Km | 21.0000 | 1 | 1 |
| vitamin k 3 | Trypanosoma cruzi | x fold | 375.0000 | 1 | 1 |
| plumbagin | Trypanosoma cruzi | Km | 15.0000 | 1 | 1 |
| plumbagin | Trypanosoma cruzi | x fold | 525.0000 | 1 | 1 |
| ajoene | Trypanosoma cruzi | Km | 2,000.0000 | 2 | 2 |
Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 19, Issue:11, 2009
Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine.Bioorganic & medicinal chemistry letters, , Oct-08, Volume: 11, Issue:19, 2001
Inhibition of Trypanosoma cruzi trypanothione reductase by acridines: kinetic studies and structure-activity relationships.Journal of medicinal chemistry, , Dec-30, Volume: 42, Issue:26, 1999
The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors.Bioorganic & medicinal chemistry, , Jul-15, Volume: 16, Issue:14, 2008
Use of an additional hydrophobic binding site, the Z site, in the rational drug design of a new class of stronger trypanothione reductase inhibitor, quaternary alkylammonium phenothiazines.Journal of medicinal chemistry, , Aug-10, Volume: 43, Issue:16, 2000
Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs.Journal of medicinal chemistry, , Jan-15, Volume: 41, Issue:2, 1998
Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity.European journal of medicinal chemistry, , Dec-01, Volume: 141, 2017
Synthesis and 2D-QSAR studies of neolignan-based diaryl-tetrahydrofuran and -furan analogues with remarkable activity against Trypanosoma cruzi and assessment of the trypanothione reductase activity.European journal of medicinal chemistry, , Nov-10, Volume: 140, 2017
Dibenzosuberyl substituted polyamines and analogs of clomipramine as effective inhibitors of trypanothione reductase; molecular docking, and assessment of trypanocidal activities.Bioorganic & medicinal chemistry, , Mar-01, Volume: 23, Issue:5, 2015
Synthesis and evaluation of the antiparasitic activity of bis-(arylmethylidene) cycloalkanones.European journal of medicinal chemistry, , Volume: 71, 2014
Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 19, Issue:11, 2009
The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors.Bioorganic & medicinal chemistry, , Jul-15, Volume: 16, Issue:14, 2008
2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.Journal of medicinal chemistry, , Feb-15, Volume: 44, Issue:4, 2001
Parallel synthesis of a library of 1,4-naphthoquinones and automated screening of potential inhibitors of trypanothione reductase from Trypanosoma cruzi.Bioorganic & medicinal chemistry letters, , Apr-03, Volume: 10, Issue:7, 2000
2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.Journal of medicinal chemistry, , Feb-15, Volume: 44, Issue:4, 2001
Parallel synthesis of a library of 1,4-naphthoquinones and automated screening of potential inhibitors of trypanothione reductase from Trypanosoma cruzi.Bioorganic & medicinal chemistry letters, , Apr-03, Volume: 10, Issue:7, 2000