Page last updated: 2024-08-07 16:49:48
Methionine aminopeptidase 1
A methionine aminopeptidase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P53582]
Synonyms
MAP 1;
MetAP 1;
EC 3.4.11.18;
Peptidase M 1
Research
Bioassay Publications (6)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (13)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 2,2'-dipyridyl | Homo sapiens (human) | EC50 | 66.7733 | 3 | 3 |
| thiabendazole | Homo sapiens (human) | EC50 | 117.8000 | 3 | 3 |
Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents.Bioorganic & medicinal chemistry, , 02-01, Volume: 25, Issue:3, 2017
Discovery of Inhibitors of ACS medicinal chemistry letters, , Jul-01, Volume: 4, Issue:8, 2013
Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 20, Issue:14, 2010
Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents.Bioorganic & medicinal chemistry, , 02-01, Volume: 25, Issue:3, 2017
Discovery of Inhibitors of ACS medicinal chemistry letters, , Jul-01, Volume: 4, Issue:8, 2013
Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.Journal of medicinal chemistry, , May-23, Volume: 56, Issue:10, 2013
Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 20, Issue:14, 2010
Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents.Bioorganic & medicinal chemistry, , 02-01, Volume: 25, Issue:3, 2017
Discovery of Inhibitors of ACS medicinal chemistry letters, , Jul-01, Volume: 4, Issue:8, 2013
Enables
This protein enables 6 target(s):
| Target | Category | Definition |
|---|
| aminopeptidase activity | molecular function | Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, PMID:24157837] |
| initiator methionyl aminopeptidase activity | molecular function | Catalysis of the release of N-terminal initiator methionine from peptides. [EC:3.4.11.18] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| metalloexopeptidase activity | molecular function | Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| metalloaminopeptidase activity | molecular function | Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE] |
Located In
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| cytosolic ribosome | cellular component | A ribosome located in the cytosol. [GOC:mtg_sensu] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Involved In
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|
| regulation of translation | biological process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. [GOC:isa_complete] |
| proteolysis | biological process | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah] |
| peptidyl-methionine modification | biological process | The modification of peptidyl-methionine. [GOC:go_curators] |
| N-terminal protein amino acid modification | biological process | The alteration of the N-terminal amino acid residue in a protein. [GOC:mah] |
| protein maturation | biological process | Any process leading to the attainment of the full functional capacity of a protein. [GOC:ai] |
| platelet aggregation | biological process | The adhesion of one platelet to one or more other platelets via adhesion molecules. [GOC:BHF, GOC:vk] |