Proteins > Phosphatidylinositol 4-kinase type 2-beta
Page last updated: 2024-08-07 13:39:57

Phosphatidylinositol 4-kinase type 2-beta

A phosphatidylinositol 4-kinase type 2-beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TCG2]

Synonyms

EC 2.7.1.67;
Phosphatidylinositol 4-kinase type II-beta;
PI4KII-BETA

Research

Bioassay Publications (1)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Compounds (13)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
9-ethyladenineHomo sapiens (human)IC5032.400011
9-ethyladenineHomo sapiens (human)Ki25.500011
n(6),n(6)-dimethyladenineHomo sapiens (human)IC50218.000011
n(6),n(6)-dimethyladenineHomo sapiens (human)Ki150.200011
1-phenyl-4-pyrazolo[3,4-d]pyrimidinamineHomo sapiens (human)IC5016.100011
1-phenyl-4-pyrazolo[3,4-d]pyrimidinamineHomo sapiens (human)Ki11.000011
sq 22536Homo sapiens (human)IC5028.200011
sq 22536Homo sapiens (human)Ki21.200011
adenosine diphosphateHomo sapiens (human)IC50145.300011
adenosine diphosphateHomo sapiens (human)Ki100.100011
2-aminopurineHomo sapiens (human)IC50341.600011
2-aminopurineHomo sapiens (human)Ki235.400011
alpha-aminopyridineHomo sapiens (human)IC507.100011
9-benzyladenineHomo sapiens (human)IC5084.400011
9-benzyladenineHomo sapiens (human)Ki57.900011
adenosineHomo sapiens (human)IC5030.300011
adenosineHomo sapiens (human)Ki19.200011
benzylaminopurineHomo sapiens (human)IC50240.400011
benzylaminopurineHomo sapiens (human)Ki199.000011
9-methyladenineHomo sapiens (human)IC50161.000011
9-methyladenineHomo sapiens (human)Ki110.900011
4-aminopyrazolo(3,4-d)pyrimidineHomo sapiens (human)IC50144.900011
4-aminopyrazolo(3,4-d)pyrimidineHomo sapiens (human)Ki99.900011
4-aminoquinazolineHomo sapiens (human)IC5091.700011
4-aminoquinazolineHomo sapiens (human)Ki63.400011

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
9-ethyladenineHomo sapiens (human)Km257.000011
sq 22536Homo sapiens (human)Km261.800011
adenosineHomo sapiens (human)Km178.900011
benzylaminopurineHomo sapiens (human)Km239.000011

Enables

This protein enables 2 target(s):

TargetCategoryDefinition
1-phosphatidylinositol 4-kinase activitymolecular functionCatalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H+. [EC:2.7.1.67, RHEA:19877]
ATP bindingmolecular functionBinding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]

Located In

This protein is located in 6 target(s):

TargetCategoryDefinition
Golgi membranecellular componentThe lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah]
endoplasmic reticulum membranecellular componentThe lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
early endosome membranecellular componentThe lipid bilayer surrounding an early endosome. [GOC:pz]

Active In

This protein is active in 3 target(s):

TargetCategoryDefinition
endosomecellular componentA vacuole to which materials ingested by endocytosis are delivered. [ISBN:0198506732, PMID:19696797]
trans-Golgi networkcellular componentThe network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. [GOC:vw, ISBN:0815316194]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 4 target(s):

TargetCategoryDefinition
phosphatidylinositol biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. [ISBN:0198506732]
phosphatidylinositol phosphate biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. [ISBN:0198506732]
endosome organizationbiological processA process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes. [GOC:dph, GOC:jl, GOC:mah]
Golgi organizationbiological processA process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. [GOC:dph, GOC:jl, GOC:mah]
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