Page last updated: 2024-08-07 15:38:12
Sodium channel protein type 1 subunit alpha
A sodium channel protein type 1 subunit alpha that is encoded in the genome of rat. [OMA:P04774, PRO:DNx]
Synonyms
Sodium channel protein brain I subunit alpha;
Sodium channel protein type I subunit alpha;
Voltage-gated sodium channel subunit alpha Nav1.1
Research
Bioassay Publications (9)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (66.67) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (20)
Drugs with Potency Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| ebselen | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 0 |
| 1,6-bismaleimidohexane | Rattus norvegicus (Norway rat) | Potency | 6.5064 | 1 | 0 |
| Adenosine 5'-monophosphate monohydrate | Rattus norvegicus (Norway rat) | Potency | 6.5064 | 1 | 0 |
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| carbamazepine | Rattus norvegicus (Norway rat) | IC50 | 167.0000 | 1 | 2 |
| racemethorphan | Rattus norvegicus (Norway rat) | IC50 | 150.6500 | 2 | 2 |
| fluoxetine | Rattus norvegicus (Norway rat) | IC50 | 13.1000 | 1 | 1 |
| lidocaine | Rattus norvegicus (Norway rat) | IC50 | 56.0000 | 1 | 2 |
| lamotrigine | Rattus norvegicus (Norway rat) | IC50 | 82.6333 | 2 | 3 |
| lidoflazine | Rattus norvegicus (Norway rat) | Ki | 0.0770 | 1 | 1 |
| mexiletine | Rattus norvegicus (Norway rat) | IC50 | 47.0000 | 1 | 1 |
| norfluoxetine | Rattus norvegicus (Norway rat) | IC50 | 0.8000 | 1 | 1 |
| sipatrigine | Rattus norvegicus (Norway rat) | IC50 | 17.8500 | 1 | 1 |
| lubeluzole | Rattus norvegicus (Norway rat) | IC50 | 2.9390 | 1 | 1 |
| lifarizine | Rattus norvegicus (Norway rat) | IC50 | 0.4940 | 1 | 1 |
| l 741742 | Rattus norvegicus (Norway rat) | Ki | 1.9000 | 1 | 1 |
| oxytocin | Rattus norvegicus (Norway rat) | Ki | 0.0610 | 1 | 2 |
| (S)-(-)-pindolol | Rattus norvegicus (Norway rat) | Ki | 0.1100 | 1 | 1 |
| flunarizine | Rattus norvegicus (Norway rat) | Ki | 0.0530 | 1 | 1 |
| dextromethorphan | Rattus norvegicus (Norway rat) | IC50 | 5.6500 | 2 | 2 |
| tetrodotoxin | Rattus norvegicus (Norway rat) | IC50 | 0.0100 | 1 | 0 |