A cGMP-dependent 3,5-cyclic phosphodiesterase that is encoded in the genome of rat. [OMA:Q01062, PRO:DNx]
EC 3.1.4.17;
Cyclic GMP-stimulated phosphodiesterase;
CGS-PDE;
cGSPDE
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| cilostamide | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| rolipram | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| zardaverine | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| quercetin pentaacetate | Rattus norvegicus (Norway rat) | IC50 | 275.0000 | 1 | 1 |
| 3,5,7,3',4'-pentamethoxyflavone | Rattus norvegicus (Norway rat) | IC50 | 96.0000 | 1 | 1 |
| penta-o-ethylquercetin | Rattus norvegicus (Norway rat) | IC50 | 350.0000 | 1 | 1 |
| quercetin | Rattus norvegicus (Norway rat) | IC50 | 81.3000 | 1 | 1 |
| sildenafil | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| zaprinast | Rattus norvegicus (Norway rat) | IC50 | 81.5500 | 2 | 2 |