Compounds > 5,11-dimethyl-5h-indolo(2,3-b)quinoline
Page last updated: 2024-11-07

5,11-dimethyl-5h-indolo(2,3-b)quinoline

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID133982
CHEMBL ID119892
SCHEMBL ID3377478
MeSH IDM0156411

Synonyms (16)

Synonym
114414-79-8
5,11-dimethyl-5h-indolo(2,3-b)quinoline
NCI60_021154
nsc660438
nsc-660438
5h-quinindoline, 4,11-dimethyl-
5,11-dimethyl-5h-quinindoline
ccris 7303
5h-quinindoline, 5,11-dimethyl-
2,3-benzo-1,4-dimethyl-alpha-iso-carboline
CHEMBL119892
SCHEMBL3377478
5,11-dimethylindolo[2,3-b]quinoline
4,11-dimethyl-6h-indolo[2,3-b]quinoline
5,11-dimethyl-5h-indolo[2,3-b]quinoline
DTXSID30921350
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (16)

Processvia Protein(s)Taxonomy
hematopoietic progenitor cell differentiationDNA topoisomerase 2-alphaHomo sapiens (human)
DNA topological changeDNA topoisomerase 2-alphaHomo sapiens (human)
DNA ligationDNA topoisomerase 2-alphaHomo sapiens (human)
DNA damage responseDNA topoisomerase 2-alphaHomo sapiens (human)
chromosome segregationDNA topoisomerase 2-alphaHomo sapiens (human)
female meiotic nuclear divisionDNA topoisomerase 2-alphaHomo sapiens (human)
apoptotic chromosome condensationDNA topoisomerase 2-alphaHomo sapiens (human)
embryonic cleavageDNA topoisomerase 2-alphaHomo sapiens (human)
regulation of circadian rhythmDNA topoisomerase 2-alphaHomo sapiens (human)
positive regulation of apoptotic processDNA topoisomerase 2-alphaHomo sapiens (human)
positive regulation of single stranded viral RNA replication via double stranded DNA intermediateDNA topoisomerase 2-alphaHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIDNA topoisomerase 2-alphaHomo sapiens (human)
rhythmic processDNA topoisomerase 2-alphaHomo sapiens (human)
negative regulation of DNA duplex unwindingDNA topoisomerase 2-alphaHomo sapiens (human)
resolution of meiotic recombination intermediatesDNA topoisomerase 2-alphaHomo sapiens (human)
sister chromatid segregationDNA topoisomerase 2-alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (13)

Processvia Protein(s)Taxonomy
magnesium ion bindingDNA topoisomerase 2-alphaHomo sapiens (human)
DNA bindingDNA topoisomerase 2-alphaHomo sapiens (human)
chromatin bindingDNA topoisomerase 2-alphaHomo sapiens (human)
RNA bindingDNA topoisomerase 2-alphaHomo sapiens (human)
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activityDNA topoisomerase 2-alphaHomo sapiens (human)
protein kinase C bindingDNA topoisomerase 2-alphaHomo sapiens (human)
protein bindingDNA topoisomerase 2-alphaHomo sapiens (human)
ATP bindingDNA topoisomerase 2-alphaHomo sapiens (human)
ATP-dependent activity, acting on DNADNA topoisomerase 2-alphaHomo sapiens (human)
DNA binding, bendingDNA topoisomerase 2-alphaHomo sapiens (human)
protein homodimerization activityDNA topoisomerase 2-alphaHomo sapiens (human)
ubiquitin bindingDNA topoisomerase 2-alphaHomo sapiens (human)
protein heterodimerization activityDNA topoisomerase 2-alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (12)

Processvia Protein(s)Taxonomy
nucleolusDNA topoisomerase 2-alphaHomo sapiens (human)
nuclear chromosomeDNA topoisomerase 2-alphaHomo sapiens (human)
centrioleDNA topoisomerase 2-alphaHomo sapiens (human)
chromosome, centromeric regionDNA topoisomerase 2-alphaHomo sapiens (human)
condensed chromosomeDNA topoisomerase 2-alphaHomo sapiens (human)
male germ cell nucleusDNA topoisomerase 2-alphaHomo sapiens (human)
nucleusDNA topoisomerase 2-alphaHomo sapiens (human)
nucleoplasmDNA topoisomerase 2-alphaHomo sapiens (human)
nucleolusDNA topoisomerase 2-alphaHomo sapiens (human)
cytoplasmDNA topoisomerase 2-alphaHomo sapiens (human)
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complexDNA topoisomerase 2-alphaHomo sapiens (human)
protein-containing complexDNA topoisomerase 2-alphaHomo sapiens (human)
ribonucleoprotein complexDNA topoisomerase 2-alphaHomo sapiens (human)
nucleusDNA topoisomerase 2-alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (57)

Assay IDTitleYearJournalArticle
AID683851Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
New derivatives of 11-methyl-6-[2-(dimethylamino)ethyl]-6H-indolo[2,3-b]quinoline as cytotoxic DNA topoisomerase II inhibitors.
AID1126871Antibacterial activity against Staphylococcus aureus NCTC 4163 assessed as growth inhibition after 18 hrs by two-fold serial dilution method2014European journal of medicinal chemistry, May-06, Volume: 78Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities.
AID683863Inhibition of human topoisomerase 2-mediated [3H]TdR-labeled catenated kinetoplast DNA decatenation after 15 to 30 mins by scintillation counting2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
New derivatives of 11-methyl-6-[2-(dimethylamino)ethyl]-6H-indolo[2,3-b]quinoline as cytotoxic DNA topoisomerase II inhibitors.
AID1262011Cytotoxicity against mouse BALB/3T3 cells assessed as cell viability after 1 hr by sulforhodamine B assay2015European journal of medicinal chemistry, Nov-13, Volume: 105The synthesis of indolo[2,3-b]quinoline derivatives with a guanidine group: highly selective cytotoxic agents.
AID689426Cytotoxicity against BALB mouse 3T3 cells after 72 hrs by SRB assay2012Journal of medicinal chemistry, Jun-14, Volume: 55, Issue:11
Synthesis and biological evaluation of new amino acid and dipeptide derivatives of neocryptolepine as anticancer agents.
AID123071Tested for antimicrobial activity against Micrococcus luteus PCM 525 at concentration of 0.01-5 uM/mL1994Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
Synthesis and structure-activity relationship of methyl-substituted indolo[2,3-b]quinolines: novel cytotoxic, DNA topoisomerase II inhibitors.
AID683850Antiproliferative activity against human A549 cells after 72 hrs by SRB assay2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
New derivatives of 11-methyl-6-[2-(dimethylamino)ethyl]-6H-indolo[2,3-b]quinoline as cytotoxic DNA topoisomerase II inhibitors.
AID1126881Antifungal activity against Candida albicans ATCC 10231 assessed as growth inhibition after 18 hrs by two-fold serial dilution method2014European journal of medicinal chemistry, May-06, Volume: 78Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities.
AID1126873Antibacterial activity against Staphylococcus aureus ATCC 6538 assessed as growth inhibition after 18 hrs by two-fold serial dilution method2014European journal of medicinal chemistry, May-06, Volume: 78Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities.
AID1126878Antibacterial activity against Enterococcus hirae ATCC 10541 assessed as growth inhibition after 18 hrs by two-fold serial dilution method2014European journal of medicinal chemistry, May-06, Volume: 78Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities.
AID1126877Antibacterial activity against Bacillus cereus ATCC 11778 assessed as growth inhibition after 18 hrs by two-fold serial dilution method2014European journal of medicinal chemistry, May-06, Volume: 78Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities.
AID683859Resistance index, ratio of IC50 for human MESSA/DX5 cells to IC50 for human MESSA cells2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
New derivatives of 11-methyl-6-[2-(dimethylamino)ethyl]-6H-indolo[2,3-b]quinoline as cytotoxic DNA topoisomerase II inhibitors.
AID1126876Antibacterial activity against Bacillus subtilis ATCC 6633 assessed as growth inhibition after 18 hrs by two-fold serial dilution method2014European journal of medicinal chemistry, May-06, Volume: 78Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities.
AID1126874Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as growth inhibition after 18 hrs by two-fold serial dilution method2014European journal of medicinal chemistry, May-06, Volume: 78Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities.
AID1126886Antifungal activity against Candida albicans SN250 assessed as inhibition of biofilm formation < MIC after 24 hrs by XTT reduction assay2014European journal of medicinal chemistry, May-06, Volume: 78Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities.
AID1262010Antiproliferative activity against human KB cells after 72 hrs by sulforhodamine B assay2015European journal of medicinal chemistry, Nov-13, Volume: 105The synthesis of indolo[2,3-b]quinoline derivatives with a guanidine group: highly selective cytotoxic agents.
AID1126882Antifungal activity against Candida albicans SN250 assessed as growth inhibition after 18 hrs by two-fold serial dilution method2014European journal of medicinal chemistry, May-06, Volume: 78Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities.
AID689429Cytotoxicity against human LoVo cells after 72 hrs by SRB assay2012Journal of medicinal chemistry, Jun-14, Volume: 55, Issue:11
Synthesis and biological evaluation of new amino acid and dipeptide derivatives of neocryptolepine as anticancer agents.
AID1126884Antifungal activity against Candida albicans ATCC 90028 assessed as growth inhibition after 18 hrs by two-fold serial dilution method2014European journal of medicinal chemistry, May-06, Volume: 78Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities.
AID1126866Cytotoxicity against mouse BALB/3T3 cells assessed as growth inhibition after 72 hrs by SRB assay2014European journal of medicinal chemistry, May-06, Volume: 78Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities.
AID683860Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
New derivatives of 11-methyl-6-[2-(dimethylamino)ethyl]-6H-indolo[2,3-b]quinoline as cytotoxic DNA topoisomerase II inhibitors.
AID1126883Antifungal activity against Candida parapsilosis ATCC 22019 assessed as growth inhibition after 18 hrs by two-fold serial dilution method2014European journal of medicinal chemistry, May-06, Volume: 78Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities.
AID1126868Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by SRB assay2014European journal of medicinal chemistry, May-06, Volume: 78Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities.
AID683855Antiproliferative activity against human LoVo/DX cells after 72 hrs by SRB assay2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
New derivatives of 11-methyl-6-[2-(dimethylamino)ethyl]-6H-indolo[2,3-b]quinoline as cytotoxic DNA topoisomerase II inhibitors.
AID48928Tested for antimicrobial activity against Candida albicans (clinical isolate) at concentration of 0.01-5 uM/mL1994Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
Synthesis and structure-activity relationship of methyl-substituted indolo[2,3-b]quinolines: novel cytotoxic, DNA topoisomerase II inhibitors.
AID25321Acid ionization constant is determined1994Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
Synthesis and structure-activity relationship of methyl-substituted indolo[2,3-b]quinolines: novel cytotoxic, DNA topoisomerase II inhibitors.
AID1262007Antiproliferative activity against human A549 cells after 72 hrs by sulforhodamine B assay2015European journal of medicinal chemistry, Nov-13, Volume: 105The synthesis of indolo[2,3-b]quinoline derivatives with a guanidine group: highly selective cytotoxic agents.
AID1126870Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by SRB assay2014European journal of medicinal chemistry, May-06, Volume: 78Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities.
AID54999Increase of calf thymus DNA denaturation temperature (delta Tm)1994Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
Synthesis and structure-activity relationship of methyl-substituted indolo[2,3-b]quinolines: novel cytotoxic, DNA topoisomerase II inhibitors.
AID1262015Induction of DNA intercalation (unknown origin) after 24 hrs by methyl green dye displacement assay2015European journal of medicinal chemistry, Nov-13, Volume: 105The synthesis of indolo[2,3-b]quinoline derivatives with a guanidine group: highly selective cytotoxic agents.
AID689425Cytotoxicity against human KB cells after 72 hrs by SRB assay2012Journal of medicinal chemistry, Jun-14, Volume: 55, Issue:11
Synthesis and biological evaluation of new amino acid and dipeptide derivatives of neocryptolepine as anticancer agents.
AID683853Antiproliferative activity against mouse BALB/3T3 cells after 72 hrs by SRB assay2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
New derivatives of 11-methyl-6-[2-(dimethylamino)ethyl]-6H-indolo[2,3-b]quinoline as cytotoxic DNA topoisomerase II inhibitors.
AID1126869Cytotoxicity against human LoVo cells assessed as growth inhibition after 72 hrs by SRB assay2014European journal of medicinal chemistry, May-06, Volume: 78Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities.
AID1126872Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as growth inhibition after 18 hrs by two-fold serial dilution method2014European journal of medicinal chemistry, May-06, Volume: 78Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities.
AID1126880Antibacterial activity against Micrococcus luteus ATCC 10240 assessed as growth inhibition after 18 hrs by two-fold serial dilution method2014European journal of medicinal chemistry, May-06, Volume: 78Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities.
AID1262009Antiproliferative activity against human LoVo cells after 72 hrs by sulforhodamine B assay2015European journal of medicinal chemistry, Nov-13, Volume: 105The synthesis of indolo[2,3-b]quinoline derivatives with a guanidine group: highly selective cytotoxic agents.
AID206160Tested for antimicrobial activity against Staphylococcus aureus PCM 458 at concentration of 0.01-5 uM/mL1994Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
Synthesis and structure-activity relationship of methyl-substituted indolo[2,3-b]quinolines: novel cytotoxic, DNA topoisomerase II inhibitors.
AID689428Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay2012Journal of medicinal chemistry, Jun-14, Volume: 55, Issue:11
Synthesis and biological evaluation of new amino acid and dipeptide derivatives of neocryptolepine as anticancer agents.
AID1262008Antiproliferative activity against human MCF7 cells after 72 hrs by sulforhodamine B assay2015European journal of medicinal chemistry, Nov-13, Volume: 105The synthesis of indolo[2,3-b]quinoline derivatives with a guanidine group: highly selective cytotoxic agents.
AID1126867Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by SRB assay2014European journal of medicinal chemistry, May-06, Volume: 78Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities.
AID683856Resistance index, ratio of IC50 for human LoVo/DX cells to IC50 for human LoVo cells2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
New derivatives of 11-methyl-6-[2-(dimethylamino)ethyl]-6H-indolo[2,3-b]quinoline as cytotoxic DNA topoisomerase II inhibitors.
AID683852Antiproliferative activity against human Hs294T cells after 72 hrs by SRB assay2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
New derivatives of 11-methyl-6-[2-(dimethylamino)ethyl]-6H-indolo[2,3-b]quinoline as cytotoxic DNA topoisomerase II inhibitors.
AID683861Antiproliferative activity against human HL60/MX2 cells after 72 hrs by SRB assay2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
New derivatives of 11-methyl-6-[2-(dimethylamino)ethyl]-6H-indolo[2,3-b]quinoline as cytotoxic DNA topoisomerase II inhibitors.
AID1126879Antibacterial activity against Micrococcus luteus ATCC 9341 assessed as growth inhibition after 18 hrs by two-fold serial dilution method2014European journal of medicinal chemistry, May-06, Volume: 78Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities.
AID689608Octanol-water partition coefficient, log P of the compound at pH 2.22012Journal of medicinal chemistry, Jun-14, Volume: 55, Issue:11
Synthesis and biological evaluation of new amino acid and dipeptide derivatives of neocryptolepine as anticancer agents.
AID689610Octanol-water partition coefficient, log P of the compound at pH 52012Journal of medicinal chemistry, Jun-14, Volume: 55, Issue:11
Synthesis and biological evaluation of new amino acid and dipeptide derivatives of neocryptolepine as anticancer agents.
AID684423Cell cycle arrest in human Jurkat T cells assessed as G2/M phase cells at 1.02 uM after 72 hrs by PI-staining2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
New derivatives of 11-methyl-6-[2-(dimethylamino)ethyl]-6H-indolo[2,3-b]quinoline as cytotoxic DNA topoisomerase II inhibitors.
AID683854Antiproliferative activity against human LoVo cells after 72 hrs by SRB assay2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
New derivatives of 11-methyl-6-[2-(dimethylamino)ethyl]-6H-indolo[2,3-b]quinoline as cytotoxic DNA topoisomerase II inhibitors.
AID1262035Hemolytic activity in sheep erythrocytes after 30 mins by spectrophotometry2015European journal of medicinal chemistry, Nov-13, Volume: 105The synthesis of indolo[2,3-b]quinoline derivatives with a guanidine group: highly selective cytotoxic agents.
AID683857Antiproliferative activity against human MESSA cells after 72 hrs by SRB assay2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
New derivatives of 11-methyl-6-[2-(dimethylamino)ethyl]-6H-indolo[2,3-b]quinoline as cytotoxic DNA topoisomerase II inhibitors.
AID689427Cytotoxicity against human A549 cells after 72 hrs by SRB assay2012Journal of medicinal chemistry, Jun-14, Volume: 55, Issue:11
Synthesis and biological evaluation of new amino acid and dipeptide derivatives of neocryptolepine as anticancer agents.
AID96015Cytotoxicity in vitro against KB cell line1994Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
Synthesis and structure-activity relationship of methyl-substituted indolo[2,3-b]quinolines: novel cytotoxic, DNA topoisomerase II inhibitors.
AID683858Antiproliferative activity against human MESSA/DX5 cells after 72 hrs by SRB assay2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
New derivatives of 11-methyl-6-[2-(dimethylamino)ethyl]-6H-indolo[2,3-b]quinoline as cytotoxic DNA topoisomerase II inhibitors.
AID214283Tested for antimicrobial activity against Trichophyton mentagrophytes (clinical isolate) at concentration of 0.01-5 uM/mL1994Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
Synthesis and structure-activity relationship of methyl-substituted indolo[2,3-b]quinolines: novel cytotoxic, DNA topoisomerase II inhibitors.
AID1126875Antibacterial activity against Staphylococcus epidermidis ATCC 12228 assessed as growth inhibition after 18 hrs by two-fold serial dilution method2014European journal of medicinal chemistry, May-06, Volume: 78Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities.
AID683849Antiproliferative activity against human KB cells after 72 hrs by SRB assay2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
New derivatives of 11-methyl-6-[2-(dimethylamino)ethyl]-6H-indolo[2,3-b]quinoline as cytotoxic DNA topoisomerase II inhibitors.
AID683862Resistance index, ratio of IC50 for human HL60/MX2 cells to IC50 for human HL60 cells2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
New derivatives of 11-methyl-6-[2-(dimethylamino)ethyl]-6H-indolo[2,3-b]quinoline as cytotoxic DNA topoisomerase II inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (9.09)18.7374
1990's2 (18.18)18.2507
2000's3 (27.27)29.6817
2010's4 (36.36)24.3611
2020's1 (9.09)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.53 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index5.02 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.53)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
amsacrine
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.. amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.		2.4120acridines;
aromatic ether;
sulfonamide		antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
ciprofloxacin
Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.		2.110aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion		antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic
ellipticine
ellipticine : A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.		1.9810indole alkaloid;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound;
polycyclic heteroarene		antineoplastic agent;
plant metabolite
fluconazole
Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.. fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.		2.110conazole antifungal drug;
difluorobenzene;
tertiary alcohol;
triazole antifungal drug		environmental contaminant;
P450 inhibitor;
xenobiotic
mitoxantrone
Mitoxantrone: An anthracenedione-derived antineoplastic agent.. mitoxantrone : A dihydroxyanthraquinone that is 1,4-dihydroxy-9,10-anthraquinone which is substituted by 6-hydroxy-1,4-diazahexyl groups at positions 5 and 8.		2.0710dihydroxyanthraquinoneanalgesic;
antineoplastic agent
1,2-dipalmitoylphosphatidylcholine
1,2-Dipalmitoylphosphatidylcholine: Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.		2.0410
daunorubicin
Daunorubicin: A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.. anthracycline : Anthracyclines are polyketides that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.. daunorubicin : A natural product found in Actinomadura roseola.		2.0710aminoglycoside antibiotic;
anthracycline;
p-quinones;
tetracenequinones		antineoplastic agent;
bacterial metabolite
1,2-dipalmitoylphosphatidylglycerol
dipalmitoyl phosphatidylglycerol : A phosphatidylglycerol in which the phosphatidyl acyl groups are both palmitoyl.		2.0410phosphatidylglycerol
dimyristoylphosphatidylglycerol
[no description available]		2.0110
neocryptolepine
neocryptolepine: isolated from the roots of the African plant Cryptolepis sanguinolenta; structure in first source		2.4220
doxorubicin hydrochloride
[no description available]		2.4920anthracycline
dimyristoylphosphatidylcholine
1,2-di-O-myristoyl-sn-glycero-3-phosphocholine : A 1,2-diacyl-sn-glycero-3-phosphocholine where the two phosphatidyl acyl groups are specified as tetradecanoyl (myristoyl).. dimyristoyl phosphatidylcholine : A phosphatidylcholine where the phosphatidyl acyl groups are specified as tetradecanoyl (myristoyl).		2.43201,2-diacyl-sn-glycero-3-phosphocholine;
phosphatidylcholine 28:0;
tetradecanoate ester		antigen;
mouse metabolite
hoe 33342
bisbenzimide ethoxide trihydrochloride: benzimidazole fluorescent dye		2.1110
ConditionIndicatedRelationship StrengthStudiesTrials
Extravascular Hemolysis
[description not available]		02.7630
Hemolysis
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.		02.7630
Benign Neoplasms
[description not available]		02.1110
Necrosis
The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.		02.1110
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.1110
Experimental Hepatoma
[description not available]		02.0410