Proteins > UDP-glucuronosyltransferase 1A4
Page last updated: 2024-08-07 18:32:04
UDP-glucuronosyltransferase 1A4
A UDP-glucuronosyltransferase 1A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P22310]
Synonyms
UGT1A4;
EC 2.4.1.17;
Bilirubin-specific UDPGT isozyme 2;
hUG-BR2;
UDP-glucuronosyltransferase 1-4;
UDPGT 1-4;
UGT1*4;
UGT1-04;
UGT1.4;
UDP-glucuronosyltransferase 1-D;
UGT-1D;
UGT1D
Research
Bioassay Publications (7)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
Compounds (42)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| ezogabine | Homo sapiens (human) | EC50 | 3.9000 | 1 | 1 |
Drugs with Other Measurements
[no title available]Journal of medicinal chemistry, , 01-09, Volume: 63, Issue:1, 2020
UDP-glucuronosyltransferases and clinical drug-drug interactions.Pharmacology & therapeutics, , Volume: 106, Issue:1, 2005
Pharmacophore and quantitative structure-activity relationship modeling: complementary approaches for the rationalization and prediction of UDP-glucuronosyltransferase 1A4 substrate selectivity.Journal of medicinal chemistry, , Apr-24, Volume: 46, Issue:9, 2003
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|
| glucuronosyltransferase activity | molecular function | Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. [RHEA:21032] |
| enzyme binding | molecular function | Binding to an enzyme, a protein with catalytic activity. [GOC:jl] |
| protein homodimerization activity | molecular function | Binding to an identical protein to form a homodimer. [GOC:jl] |
| protein heterodimerization activity | molecular function | Binding to a nonidentical protein to form a heterodimer. [GOC:ai] |
Located In
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
Involved In
This protein is involved in 4 target(s):
| Target | Category | Definition |
|---|
| bilirubin conjugation | biological process | The chemical reactions and pathways resulting in the formation of bilirubin monoglucuronide or bilirubin diglucuronide, water-soluble derivatives of bilirubin. [DOI:10.1016/0305-0491(80)90243-6] |
| heme catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:jl] |
| cellular glucuronidation | biological process | The modification of an organic chemical by the conjugation of glucuronic acid. The substances resulting from glucuronidation are known as glucuronosides (or glucuronides) and are often much more water-soluble than the non-glucuronic acid-containing precursor. [GOC:BHF] |
| vitamin D3 metabolic process | biological process | The chemical reactions and pathways involving vitamin D3, (3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol. [GOC:BHF, GOC:mah] |