Page last updated: 2024-12-05

monomethylarsonic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

monomethylarsonic acid: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID8948
CHEMBL ID1743208
CHEBI ID29852
SCHEMBL ID122145
MeSH IDM0073906

Synonyms (41)

Synonym
methanearsonic acid
measo(oh)2
CHEBI:29852 ,
monomethylarsonic acid
NCIOPEN2_000522
NCIOPEN2_000482
brn 1739373
kyselina methylarsonova [czech]
einecs 204-705-6
methylarsinic acid
methylarsenic acid
methylarsonic acid [iso]
hsdb 845
monomethylarsonate
dsma (jmaf)
monomethylarsinic acid
4950-59-8
arsonic acid, methyl-
124-58-3
C07294
methylarsonic acid
NCIOPEN2_004484
NCIOPEN2_008444
CHEMBL1743208
4-04-00-03682 (beilstein handbook reference)
ccris 9324
unii-j37vj5709s
kyselina methylarsonova
j37vj5709s ,
methylarsonic acid [hsdb]
methanearsonic acid [who-dd]
methanearsonic acid [mi]
methylarsonic acid [iarc]
monomethylarsonic acid (see methylarsonic acid) [iarc]
SCHEMBL122145
QYPPRTNMGCREIM-UHFFFAOYSA-N
methyl arsonic acid
DTXSID4020903
Q1976186
monomethylarsonic acid standard solution
AKOS040753035

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Cells pretreated with a low As(III) concentration are less sensitive to toxic doses of As(III) or As(V)."( Arsenic uptake, cytotoxicity and detoxification studied in mammalian cells in culture.
Buchet, JP; Fischer, AB; Lauwerys, RR, 1985
)
0.27
" A methylation threshold hypothesis for In-As has been proposed, stating that after exposure to In-As reaches a certain level or threshold, methylation capacity begins to decline, thus increasing the toxic effects of In-As."( Human studies do not support the methylation threshold hypothesis for the toxicity of inorganic arsenic.
Goeden, HM; Hopenhayn-Rich, C; Smith, AH, 1993
)
0.29
"AC) mice that had received sodium arsenite [(As(III)] in drinking water, indicating that this model is useful for studying the toxic effects of arsenic in vivo."( Biokinetics and subchronic toxic effects of oral arsenite, arsenate, monomethylarsonic acid, and dimethylarsinic acid in v-Ha-ras transgenic (Tg.AC) mice.
Germolec, DR; Liu, J; Trouba, KJ; Waalkes, MP; Xie, Y, 2004
)
0.56
" In previous studies we have shown that the trivalent organoarsenic compounds are more toxic than their inorganic counterparts and that the toxicity is associated with the cellular uptake of the arsenicals."( Forced uptake of trivalent and pentavalent methylated and inorganic arsenic and its cyto-/genotoxicity in fibroblasts and hepatoma cells.
Dopp, E; Florea, AM; Hartmann, LM; Hirner, AV; Rabieh, S; Rettenmeier, AW; Shokouhi, B; von Recklinghausen, U; Yadav, S; Zimmermann, U, 2005
)
0.33
" Based on pregnancy outcome, the developmental toxicity no observed adverse effect level (NOAEL) for orally administered MMAV were 100 and 7 mg/kg/day in the rat and rabbit, respectively, and for DMAV were 12 mg/kg/day in both species."( Monomethylarsonic acid and dimethylarsinic acid: developmental toxicity studies with risk assessment.
Boyer, IJ; DeSesso, JM; Irvine, L, 2006
)
1.78
" The herbicide mixture alone displayed half the toxicity of the individual herbicides, but the mixture with surfactant was twice as toxic as the individual herbicides."( Toxicity of a mixture of 2,4-dichlorophenoxyacetic acid and monosoduim methanearsonate to the red swamp crawfish, Procambarus clarkii.
Abdelghani, AA; Green, RM, 2004
)
0.32
" The current work lays the groundwork for using Nrf2 activators for therapeutic and dietary interventions against adverse effects of arsenic."( Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity.
Chen, W; Eblin, KE; Gandolfi, JA; Sun, Z; Wang, XJ; Zhang, DD, 2007
)
0.34
" Here we examined the effects of MSMA in the laboratory using the zebra finch (Taeniopygia guttata), with the objective to examine tissue distribution and sublethal toxic effects in a model avian species."( Dose-dependent uptake, elimination, and toxicity of monosodium methanearsonate in adult zebra finches (Taeniopygia guttata).
Albert, CA; Cullen, WR; Elliott, JE; Lai, VW; Morrissey, CA; Williams, TD, 2008
)
0.35
" The gastrointestinal mucosa is exposed to these forms of arsenic, but it is not known what toxic effect these species may have on it."( Differential toxicity and gene expression in Caco-2 cells exposed to arsenic species.
Calatayud, M; Devesa, V; Vélez, D, 2013
)
0.39
" Discussion of the health risk of As in rice has largely been based on its inorganic arsenic content because these species have generally been considered to be more toxic than MMA and DMA and can be directly compared to As in drinking water, assuming equal bioavailability of inorganic As in the rice matrix and in water."( Arsenic toxicity in rice with special reference to speciation in Indian grain and its implication on human health.
Bhattacharyya, K; Sinha, B, 2015
)
0.42

Pharmacokinetics

ExcerptReferenceRelevance
"The pharmacokinetic behaviour of gentamicin sulphate (3."( Effect of sodium methyl arsinate and imidocarb dipropionate antiprotozoal drugs on the pharmacokinetic of gentamicin in equines.
Soliman, GA, 1998
)
0.3
" In order to investigate the potential role of tissue dosimetry in differential susceptibility to arsenic carcinogenicity, a physiologically based pharmacokinetic (PBPK) model for inorganic arsenic in the rat, hamster, monkey, and human (Mann et al."( Physiologically based pharmacokinetic modeling of arsenic in the mouse.
Clewell, HJ; Covington, TR; Gentry, PR; Mann, S; Shipp, AM; Yager, JW, 2004
)
0.32

Compound-Compound Interactions

ExcerptReferenceRelevance
" This paper emphasizes the usefulness of complementary chromatographic separations in combination with HG-ICPMS to quantitatively determine concentrations of As(III), DMA(V), MMA(V), As(V), and AsB in the sub-microgram per liter range in human urine."( Complementary chromatography separation combined with hydride generation-inductively coupled plasma mass spectrometry for arsenic speciation in human urine.
Chen, LW; Le, XC; Lu, X, 2010
)
0.36

Bioavailability

ExcerptReferenceRelevance
" The importance of using permeability coefficients rather than n-octanol/water partition coefficients in determining bioavailability and bioaccumulation of environmentally sensitive compounds is also discussed."( Vesicular membrane permeability of monomethylarsonic and dimethylarsinic acids.
Cullen, WR; Herring, FG; Males, RG; Nelson, JC; Phillips, PS, 1998
)
0.3
" The distinction between "free" As and colloid-bound/complexed As in soil solution is important for understanding the mobility and bioavailability of As in the environment."( Interactions of arsenic and the dissolved substances derived from turf soils.
Cai, Y; Chen, Z; Cisar, JL; Snyder, GH; Solo-Gabriele, H, 2006
)
0.33
" The mobility and bioavailability of these arsenic species in the environment are strongly influenced by their interactions with mineral surface, especially iron and aluminum oxides."( Effect of replacing a hydroxyl group with a methyl group on arsenic (V) species adsorption on goethite (alpha-FeOOH).
Pehkonen, SO; Stanforth, RS; Zhang, JS, 2007
)
0.34
" The implications of the results with respect to arsenic species bioavailability and toxicity in marine water are further discussed."( The biouptake and toxicity of arsenic species on the green microalga Chlorella salina in seawater.
Karadjova, IB; Slaveykova, VI; Tsalev, DL, 2008
)
0.35
"The aim of this study was to evaluate the bioavailability of arsenic (As) through cultured oyster Crassostrea gigas and Crassostrea corteziensis from four coastal lagoons (SE Gulf of California)."( Arsenic and arsenic species in cultured oyster (Crassostrea gigas and C. corteziensis) from coastal lagoons of the SE Gulf of California, Mexico.
Bergés-Tiznado, ME; Notti, A; Páez-Osuna, F; Regoli, F, 2013
)
0.39
" Bioavailability or mobility of inorganic As in soil has been reported to be significantly influenced by soil minerals such as iron (hydr) oxide; however, the interactions of organic As such as monosodium methanearsonate (MSMA) with soil minerals are little studied, thus largely unknown."( Response of rice genotype to straighthead disease as influenced by arsenic level and water management practices in soil.
Hua, B; Yan, W; Yang, J, 2013
)
0.39
" Discussion of the health risk of As in rice has largely been based on its inorganic arsenic content because these species have generally been considered to be more toxic than MMA and DMA and can be directly compared to As in drinking water, assuming equal bioavailability of inorganic As in the rice matrix and in water."( Arsenic toxicity in rice with special reference to speciation in Indian grain and its implication on human health.
Bhattacharyya, K; Sinha, B, 2015
)
0.42

Dosage Studied

Nestling finches were orally dosed for 20 d from hatching to fledging with 4, 8, 12, 24, 36, or 72 microg/g bw/d of monomethylarsonic acid. The blood and organ concentrations of the arsenic species were studied on day 1 (single-dose study), day 30 (multiple dosing study), and day 60 (reversibility study)

ExcerptRelevanceReference
"To investigate the distribution of trivalent arsenic (arsenite) in the pregnant rodent, CD-1 mice were dosed with sodium arsenite by ip injection or by gavage on gestation d 18 (copulation plug day = d 1)."( Uptake, distribution, and metabolism of trivalent arsenic in the pregnant mouse.
Hood, RD; Meeks, RG; Tatum, FM; Vedel, GC; Zaworotko, MJ, 1988
)
0.27
" The total arsenic concentration in blood and milk was measured during and after the period of MSMA administration while arsenic in urine and feces was measured for 10 days following administration of last dosage of MSMA."( Uptake, distribution and elimination of monosodium methanearsonate following long term oral administration of the herbicide to sheep and goats.
Anderson, AC; Shariatpanahi, M, 1984
)
0.27
"4%) was absorbed from aqueous vehicles over the entire dosage range."( In vitro percutaneous absorption of monosodium methanearsonate and disodium methanearsonate in female B6C3F1 mice.
Hughes, MF; Rahman, MS, 1994
)
0.29
" Although most study subjects had stopped consuming high-arsenic artesian well water more than 20 years ago, the risk of skin cancer was found to increase significantly with cumulative arsenic exposure before the cessation of drinking artesian well water in a dose-response relationship."( Serum beta-carotene level, arsenic methylation capability, and incidence of skin cancer.
Chen, CJ; Chen, GS; Chiou, HY; Hsueh, YM; Huang, CC; Huang, YL; Lue, LC; Wu, WL; Yang, MH, 1997
)
0.3
" Up to two fold increases of urinary ASi excretion in rats compared with control rats were also observed in animals dosed with various forms of arsenicals."( Speciation of arsenic metabolites in the urine of occupational workers and experimental rats using an optimised hydride cold-trapping method.
Chiswell, B; Imray, P; Johnson, D; Moore, MR; Ng, JC, 1998
)
0.3
" Other possible explanations may relate to strain-specific differences, or to the different durations of dosing in each of the mouse studies, given the evidence that inorganic arsenic is likely to be active in the later stages of the carcinogenic process."( Physiologically based pharmacokinetic modeling of arsenic in the mouse.
Clewell, HJ; Covington, TR; Gentry, PR; Mann, S; Shipp, AM; Yager, JW, 2004
)
0.32
" The blood and organ concentrations of the arsenic species, including As(III), dimethylarsinic acid (DMA), and monomethylarsonic acid (MMA), were studied on day 1 (single-dose study), day 30 (multiple dosing study), and day 60 (reversibility study)."( Tissue distribution of arsenic species in rabbits after single and multiple parenteral administration of arsenic trioxide: tissue accumulation and the reversibility after washout are tissue-selective.
Cheng, AL; Hsueh, YM; Lin, CJ; Sun, SS; Wu, MH, 2005
)
0.54
" Peak concentrations of DMA in kidney were achieved at 2 h post dosing for both dose levels."( Tissue distribution and urinary excretion of inorganic arsenic and its methylated metabolites in mice following acute oral administration of arsenate.
Del Razo, LM; Hughes, MF; Kenyon, EM, 2005
)
0.33
" Furthermore, the evidence strongly supports a nonlinear dose-response relationship for the biologic processes involved in the carcinogenicity of arsenicals."( Methylated arsenicals: the implications of metabolism and carcinogenicity studies in rodents to human risk assessment.
Arnold, LL; Beck, BD; Cohen, SM; Eldan, M; Lewis, AS, 2006
)
0.33
"Cumulative arsenic exposure (CAE) from drinking water has been shown to be associated with hypertension in a dose-response pattern."( Arsenic methylation capability and hypertension risk in subjects living in arseniasis-hyperendemic areas in southwestern Taiwan.
Chen, CJ; Hsueh, YM; Huang, YK; Huang, YL; Tseng, CH; Yang, MH, 2007
)
0.34
" Nestling finches were orally dosed for 20 d from hatching to fledging with 4, 8, 12, 24, 36, or 72 microg/g bw/d of monomethylarsonic acid (MMA(V), which corresponds to MSMA at physiological pH)."( Tissue uptake, mortality, and sublethal effects of monomethylarsonic acid (MMA(V)) in nestling zebra finches (Taeniopygia guttata).
Albert, C; Cullen, WR; Elliott, JE; Lai, VW; Morrissey, CA; Williams, TD, 2008
)
0.81
"Capillary electrophoresis coupled to inductively coupled plasma mass spectrometry was used in a speciation study on disodium monomethylarsonate (DS-MMA(V)) and its metabolites in horses, to which the drug was administered by intramuscular injection on five consecutive days at a single arsenic dosage of 270 mg day(-1)."( Intake and excretion of disodium monomethylarsonate in horses: a speciation study.
Assis, RA; Kuchler, IL; Miekeley, N; Tozzi, MB, 2008
)
0.35
" f BY-3) were investigated as a function of pH, contact time, initial arsenic concentration, biomass dosage and temperature in this study."( Biosorption of inorganic and organic arsenic from aqueous solution by Acidithiobacillus ferrooxidans BY-3.
Leng, F; Li, H; Nan, W; Yan, L; Yin, H; Zhang, S, 2010
)
0.36
" By coupling the age-specific physiologically based pharmacokinetic (PBPK) model and a Weibull-based dose-response function, a more accurate estimate of urinary arsenic metabolites could be achieved to better characterize potential cancer risks."( Assessing the cancer risk associated with arsenic-contaminated seafood.
Chen, BC; Chen, WY; Chou, WC; Liao, CM, 2010
)
0.36
" However, higher UAs was modestly associated with higher scores on the Oppositional, Cognitive Problems and ADHD sub-scales of the teacher ratings; a dose-response relationship was not established between UAs quartiles and behavior."( Association between arsenic exposure and behavior among first-graders from Torreón, Mexico.
Cebrian, ME; Kordas, K; Lopez, P; Ronquillo, D; Rosado, JL; Roy, A; Stoltzfus, RJ; Vargas, GG, 2011
)
0.37
"Forty-eight Wistar rats were divided into 4 groups randomly:control group,low dosage group, moderate dosage group and high dosage group."( [Effect of subchronic realgar exposure on Glu and Gln in infant rat brain].
Chang, B; Huo, TG; Jiang, H; Li, WK; Sun, GF; Yang, HL; Zhang, YH, 2012
)
0.38
"The levels of MMA and DMA in brain increased as the dosage of realgar increased, while the second methylation index declined."( [Effect of subchronic realgar exposure on Glu and Gln in infant rat brain].
Chang, B; Huo, TG; Jiang, H; Li, WK; Sun, GF; Yang, HL; Zhang, YH, 2012
)
0.38
" In addition, the contents of total arsenic and arsenic species in earthworms were also determined to investigate the effects of bioaccumulation and biotransformation of arsenic on biomarkers and to evaluate the dose-response relationships."( Toxicological and biochemical responses of the earthworm Eisenia fetida exposed to contaminated soil: Effects of arsenic species.
Cui, Z; Liu, L; Ma, Q; Wang, Z; Xu, X, 2016
)
0.43
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (3)

ClassDescription
organoarsonic acidAny organoarsenic compound that is the As-organyl derivative of arsonic acid.
arsonic acidsArsonic acid and its As-hydrocarbyl derivatives.
one-carbon compoundAn organic molecular entity containing a single carbon atom (C1).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (3)

PathwayProteinsCompounds
Arsenic uptake and detoxification77
Arsenate Detoxification716
Responses to stimuli: abiotic stimuli and stresses9526

Research

Studies (392)

TimeframeStudies, This Drug (%)All Drugs %
pre-199036 (9.18)18.7374
1990's49 (12.50)18.2507
2000's134 (34.18)29.6817
2010's153 (39.03)24.3611
2020's20 (5.10)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.49

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.49 (24.57)
Research Supply Index6.02 (2.92)
Research Growth Index4.84 (4.65)
Search Engine Demand Index29.35 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.49)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials8 (1.98%)5.53%
Reviews6 (1.49%)6.00%
Case Studies7 (1.73%)4.05%
Observational0 (0.00%)0.25%
Other383 (94.80%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]