Ubiquitin carboxyl-terminal hydrolase isozyme L3

A ubiquitin carboxyl-terminal hydrolase isozyme L3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P15374]

UCH-L3;
EC 3.4.19.12;
Ubiquitin thioesterase L3

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
vitamin k 3	Homo sapiens (human)	IC50	71.0000	2	2
celastrol	Homo sapiens (human)	IC50	31.4000	1	5
perifosine	Homo sapiens (human)	IC50	0.0500	1	1
4,5,6,7-tetrachloroindan-1,3-dione	Homo sapiens (human)	IC50	0.6000	2	2
9-deoxy-delta-9-prostaglandin d2	Homo sapiens (human)	IC50	10.0000	1	1
acetyl isogambogic acid	Homo sapiens (human)	IC50	17.3200	1	5
ldn 57444	Homo sapiens (human)	IC50	25.0000	1	1

This protein enables 5 target(s):

Target	Category	Definition
cysteine-type deubiquitinase activity	molecular function	An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. [GOC:jh2, PMID:30783221]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
peptidase activity	molecular function	Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. [GOC:jl, ISBN:0815332181]
deNEDDylase activity	molecular function	An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated. [GOC:mah, PMID:25628956]
ubiquitin binding	molecular function	Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. [GOC:ecd]

This protein is located in 2 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

This protein is involved in 5 target(s):

Target	Category	Definition
ubiquitin-dependent protein catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. [GOC:go_curators]
protein ubiquitination	biological process	The process in which one or more ubiquitin groups are added to a protein. [GOC:ai]
protein deubiquitination	biological process	The removal of one or more ubiquitin groups from a protein. [GOC:ai]
protein catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. [GOC:mah]
post-translational protein modification	biological process	The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome. [GOC:jsg]