pyrazines has been researched along with Necrosis in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (26.67) | 18.7374 |
| 1990's | 1 (3.33) | 18.2507 |
| 2000's | 10 (33.33) | 29.6817 |
| 2010's | 9 (30.00) | 24.3611 |
| 2020's | 2 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Beylot-Barry, M; Protin, C; Recher, C; Sibaud, V; Vigarios, E; Ysebaert, L | 1 |
| Lou, H; Ma, J; Shen, X; Sun, Q; Zhang, Q | 1 |
| Adams, GP; Balachandran, S; Chen, P; Nogusa, S; Peri, S; Shaller, C; Simmons, H; Thapa, RJ | 1 |
| Balachandran, S; Chen, P; Cheung, M; Nogusa, S; Pei, J; Peri, S; Testa, JR; Thapa, RJ | 1 |
| Rouse, R; Stewart, S; Xu, L; Zhang, J | 1 |
| Bailey, Z; Bolyard, C; Caligiuri, MA; Cripe, TP; Eaves, D; He, S; Hurwitz, BS; Kaur, B; Old, M; Parris, DS; Rath, KS; Selvendiran, K; Yoo, JY; Yu, J; Yu, JG; Zhang, J | 1 |
| Ando, Y; Fujiwara, S; Hata, H; Iida, S; Kawano, Y; Kikukawa, Y; Mitsuya, H; Nakashima, T; Okuno, Y; Ri, M; Shiotsu, Y; Tasaki, M; Ueda, M; Wada, N; Yoshinaga, K | 1 |
| Ide, S; Kojima, S; Nakanishi, Y; Nishino, K; Tanamachi, K; Tanuma, S; Tsukimoto, M | 1 |
| Chao, B; Gao, AH; He, QJ; Hu, YH; Li, J; Ma, YM; Peng, YM; Zhou, YB; Zhu, QH | 1 |
| Careddu, G; Carlo-Stella, C; Castagna, L; Locatelli, SL; Santoro, A; Stirparo, GG | 1 |
| McConkey, DJ | 1 |
| Brandes, G; Buer, J; Carlomagno, T; Frank, R; Geffers, R; Gossler, A; Gütgemann, I; Kalesse, M; Kubicka, S; Malek, NP; Manns, MP; Menche, D; Nickeleit, I; Sasse, F; Sörensen, I; Steinmetz, H; Zender, S | 1 |
| Fels, DR; Koong, AC; Koumenis, C; Kridel, SJ; Olson, M; Segan, AT; Spiotto, M; Ye, J | 1 |
| Bernardi, P; Brancolini, C; Crivellato, E; Demarchi, F; Fontanini, A; Foti, C; Maestro, R; Potu, H | 1 |
| Brancolini, C; Demarchi, F; Foti, C | 1 |
| Eller, K; Heininger, D; Huber, JM; Mayer, G; Rosenkranz, AR; Tagwerker, A | 1 |
| Brancolini, C; Florean, C; Foti, C; Gustincich, S; Pezzutto, A; Roncaglia, P; Tomasella, A | 1 |
| Bagot, M; Bezier, M; Cordoliani, F; Delyon, J; Malphettes, M; Rybojad, M; Szalat, R | 1 |
| Anderson, KC; Bonham, L; Chauhan, D; Hideshima, H; Hideshima, T; Ishitsuka, K; Kumar, S; Mitsiades, C; Munshi, NC; Podar, K; Raje, N; Richardson, PG; Singer, JW; Yasui, H | 1 |
| Cao, X; Cullen, MJ; Devenny, J; Hung, CP; Janovitz, E; Keim, WJ; Lehman-McKeeman, L; Malley, MF; Malmstrom, SE; Miller, KJ; Narayanan, R; Pelleymounter, MA; Qu, Q; Robl, JA; Rohrbach, KW; Rossi, K; Thomas, MA; Ung, T; Varnes, JG; Wacker, DA; Wu, G; Zhang, G; Zuvich, E | 1 |
| Al-Moundhri, M; Al-Siyabi, S; Ali, BH; Annamalai, K; Eldin, MT; Nemmar, A | 1 |
| Wang, XP; Xu, JY; Yuan, YZ | 1 |
| Barrett, RJ; Harleman, JH; Joseph, EC | 1 |
| Bennett, WM; Houghton, DC; Porter, GA; Purnell, J | 1 |
| Savoie, LL | 1 |
| Savoie, L; Selye, H; Somogyi, A | 1 |
| Grinnell, E; Prioreschi, P; Sullivan, R | 1 |
| Classen, HG; Solymoss, B; Varga, S | 2 |
| Blascheck, JA; Gardell, C; Kovács, K | 1 |
1 review(s) available for pyrazines and Necrosis
| Article | Year |
|---|---|
Dermatological Toxicities of Bruton's Tyrosine Kinase Inhibitors.
Topics: Adenine; Administration, Cutaneous; Agammaglobulinaemia Tyrosine Kinase; Benzamides; Biopsy; Drug Eruptions; Ecchymosis; Emollients; Humans; Incidence; Leukemia, Lymphocytic, Chronic, B-Cell; Necrosis; Patient Education as Topic; Piperidines; Protein Kinase Inhibitors; Pyrazines; Pyrazoles; Pyrimidines; Receptors, Antigen, B-Cell; Severity of Illness Index; Signal Transduction; Skin; Skin Care | 2020 |
29 other study(ies) available for pyrazines and Necrosis
| Article | Year |
|---|---|
Activation of Nrf2 signaling by oltipraz inhibits death of human macrophages with mycobacterium tuberculosis infection.
Topics: Apoptosis; Cytoprotection; Humans; Macrophages; Necrosis; NF-E2-Related Factor 2; Oxidative Stress; Pyrazines; Signal Transduction; Thiones; Thiophenes; Tuberculosis | 2020 |
Anti-CD70 immunocytokines for exploitation of interferon-γ-induced RIP1-dependent necrosis in renal cell carcinoma.
Topics: Animals; Antiviral Agents; Boronic Acids; Bortezomib; Carcinoma, Renal Cell; CD27 Ligand; Cell Death; Cell Line, Tumor; Humans; Interferon-gamma; Kidney Neoplasms; Mice; Necrosis; Phosphorylation; Protein Binding; Pyrazines; Receptor-Interacting Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; Signal Transduction; Species Specificity; STAT1 Transcription Factor | 2013 |
NF-κB inhibition by bortezomib permits IFN-γ-activated RIP1 kinase-dependent necrosis in renal cell carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Carcinoma, Renal Cell; Cell Line, Tumor; Enzyme Activation; Humans; I-kappa B Kinase; Interferon-gamma; Kidney Neoplasms; Necrosis; NF-kappa B; Proteasome Inhibitors; Pyrazines; Receptor-Interacting Protein Serine-Threonine Kinases | 2013 |
High fat diet and GLP-1 drugs induce pancreatic injury in mice.
Topics: Acute Disease; Animals; Apoptosis; Atrophy; Diet, High-Fat; Exenatide; Glucagon-Like Peptide-1 Receptor; Hypoglycemic Agents; Male; Mice; Mice, Inbred C57BL; Necrosis; Pancreas; Pancreatitis; Peptides; Pyrazines; Receptors, Glucagon; Sitagliptin Phosphate; Triazoles; Venoms | 2014 |
Bortezomib-induced unfolded protein response increases oncolytic HSV-1 replication resulting in synergistic antitumor effects.
Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Line, Tumor; Combined Modality Therapy; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Female; Herpesvirus 1, Human; Humans; Mice, Nude; Necrosis; Oncolytic Virotherapy; Oncolytic Viruses; Pyrazines; Unfolded Protein Response; Virus Replication; Xenograft Model Antitumor Assays | 2014 |
Shikonin, dually functions as a proteasome inhibitor and a necroptosis inducer in multiple myeloma cells.
Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Death; Cell Line, Tumor; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Endoplasmic Reticulum Stress; Humans; Imidazoles; Indoles; Multiple Myeloma; Naphthoquinones; Necrosis; Proteasome Inhibitors; Purine Nucleosides; Pyrazines; Regulatory Factor X Transcription Factors; Transcription Factors; X-Box Binding Protein 1 | 2015 |
Radiosensitizing Effect of TRPV1 Channel Inhibitors in Cancer Cells.
Topics: Acrylamides; Anilides; Animals; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cell Line, Tumor; Cell Survival; Cinnamates; DNA Damage; Gamma Rays; Humans; Mice; Necrosis; Neoplasms; Pyrazines; Pyridines; Radiation-Sensitizing Agents; TRPV Cation Channels | 2016 |
Novel CHOP activator LGH00168 induces necroptosis in A549 human lung cancer cells via ROS-mediated ER stress and NF-κB inhibition.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Endoplasmic Reticulum Stress; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Necrosis; NF-kappa B; Pyrazines; Pyrimidines; Reactive Oxygen Species | 2016 |
Dual PI3K/ERK inhibition induces necroptotic cell death of Hodgkin Lymphoma cells through IER3 downregulation.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Death; Cell Line, Tumor; Down-Regulation; Enzyme Inhibitors; Gene Expression; Hodgkin Disease; Humans; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Inbred NOD; Mice, SCID; Mitogen-Activated Protein Kinase Kinases; Necrosis; Phosphoinositide-3 Kinase Inhibitors; Pyrazines; Reactive Oxygen Species; RNA, Small Interfering; Xenograft Model Antitumor Assays | 2016 |
A novel role for a familiar protein in apoptosis induced by proteasome inhibition.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Blood Vessels; Boronic Acids; Bortezomib; Cell Cycle; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Humans; Intracellular Signaling Peptides and Proteins; Necrosis; Neoplasms; Neovascularization, Pathologic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Pyrazines; Time Factors; Up-Regulation | 2008 |
Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Blood Vessels; Boronic Acids; Bortezomib; Cell Cycle; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; HCT116 Cells; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mice, Nude; Necrosis; Neoplasms; Neovascularization, Pathologic; Peptides, Cyclic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Pyrazines; RNA Interference; RNA, Small Interfering; Time Factors; Transfection; Up-Regulation; Xenograft Model Antitumor Assays | 2008 |
Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways.
Topics: Activating Transcription Factor 4; Antineoplastic Agents; Apoptosis; Autophagy; Boronic Acids; Bortezomib; Cell Hypoxia; Cell Line, Tumor; DNA-Binding Proteins; Endoplasmic Reticulum; Humans; Microtubule-Associated Proteins; Necrosis; Protease Inhibitors; Protein Folding; Pyrazines; Regulatory Factor X Transcription Factors; Signal Transduction; Stress, Physiological; Thapsigargin; Transcription Factors | 2008 |
The Isopeptidase Inhibitor G5 Triggers a Caspase-independent Necrotic Death in Cells Resistant to Apoptosis: A COMPARATIVE STUDY WITH THE PROTEASOME INHIBITOR BORTEZOMIB.
Topics: Actins; Animals; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-X Protein; Boronic Acids; Bortezomib; Carbon-Nitrogen Lyases; Cell Adhesion; Cell Line, Transformed; Collagen; Cyclosporine; Cytoskeleton; Extracellular Matrix; Fibronectins; HMGB1 Protein; MAP Kinase Kinase 4; Membrane Potential, Mitochondrial; Mice; Mice, Knockout; Necrosis; Peroxisome Proliferator-Activated Receptors; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrans; Pyrazines; Sulfhydryl Compounds | 2009 |
Inhibitors of the ubiquitin-proteasome system are not all alike: identification of a new necrotic pathway.
Topics: Animals; Autophagy; Boronic Acids; Bortezomib; Enzyme Inhibitors; Fibroblasts; Mice; Necrosis; Proteasome Endopeptidase Complex; Pyrazines; Ubiquitin | 2009 |
The proteasome inhibitor bortezomib aggravates renal ischemia-reperfusion injury.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Boronic Acids; Bortezomib; CD4 Lymphocyte Count; Creatinine; Cyclin-Dependent Kinase Inhibitor p21; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intravenous; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Necrosis; Nephritis; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Reperfusion Injury; Time Factors | 2009 |
Characterization of caspase-dependent and caspase-independent deaths in glioblastoma cells treated with inhibitors of the ubiquitin-proteasome system.
Topics: Apoptosis; Boronic Acids; Bortezomib; Caspases; Cell Death; Cell Line, Tumor; Gene Expression Profiling; Glioblastoma; Glutathione; Humans; Microarray Analysis; Necrosis; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyrans; Pyrazines; Sulfhydryl Compounds; Ubiquitin | 2009 |
[Cutaneous manifestations revealing cryofibrinogenaemia associated with monoclonal gammopathy].
Topics: Acute Kidney Injury; Adult; Aged, 80 and over; Anti-Inflammatory Agents; Antineoplastic Agents; Biopsy; Boronic Acids; Bortezomib; Cryoglobulinemia; Cryoglobulins; Cyclophosphamide; Dexamethasone; Drug Therapy, Combination; Female; Fibrinogens, Abnormal; Humans; Immunoglobulin kappa-Chains; Immunoglobulin lambda-Chains; Kidney; Leg Ulcer; Microscopy, Fluorescence; Necrosis; Paraproteinemias; Plasmapheresis; Prednisone; Pyrazines; Skin | 2013 |
Molecular characterization of PS-341 (bortezomib) resistance: implications for overcoming resistance using lysophosphatidic acid acyltransferase (LPAAT)-beta inhibitors.
Topics: Acyltransferases; Adenosine Triphosphate; Apoptosis; Apoptosis Regulatory Proteins; Boronic Acids; Bortezomib; Caspase 3; Caspase 8; Caspase 9; Caspases; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Flow Cytometry; G2 Phase; Humans; Immunoblotting; In Situ Nick-End Labeling; Multiple Myeloma; Necrosis; Phosphorylation; Poly(ADP-ribose) Polymerases; Protease Inhibitors; Proteasome Inhibitors; Proteins; Pyrazines; Time Factors; Treatment Outcome | 2005 |
Discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a selective, orally active agonist of the 5-HT(2C) receptor.
Topics: Administration, Oral; Animals; Anti-Obesity Agents; Blood-Brain Barrier; Cell Line; Conditioning, Operant; Feeding Behavior; Humans; Indoles; Isoindoles; Male; Mice; Necrosis; Parietal Cells, Gastric; Pyrazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Serotonin 5-HT2 Receptor Agonists; Stereoisomerism; Weight Gain | 2007 |
Amelioration of cisplatin-induced nephrotoxicity in rats by tetramethylpyrazine, a major constituent of the Chinese herb Ligusticum wallichi.
Topics: Animals; Antineoplastic Agents; Cisplatin; Creatinine; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Glutathione; Kidney; Ligusticum; Lipid Peroxidation; Male; Necrosis; Pyrazines; Rats; Rats, Wistar; Superoxide Dismutase; Urea | 2008 |
[Therapeutic effects and mechanisms of tetramethylpyrazine on lung injury in acute haemorrhagic necrotizing pancreatitis in rats].
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Free Radical Scavengers; Lipid Peroxides; Lung; Necrosis; Pancreatitis; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Thromboxane B2 | 1993 |
The evaluation of HBDH and LDH isoenzymes in cardiac cell necrosis of the rat.
Topics: Animals; Female; Heart; Humans; Hydroxybutyrate Dehydrogenase; Isoenzymes; Isoproterenol; L-Lactate Dehydrogenase; Male; Myocardium; Necrosis; Pyrazines; Rats; Rats, Inbred Strains; Tissue Distribution | 1988 |
Effect of amiloride on experimental gentamicin nephrotoxicity.
Topics: Amiloride; Animals; Diet; Drug Interactions; Gentamicins; Inulin; Kidney; Kidney Cortex; Kidney Diseases; Kidney Tubules; Magnesium; Male; Necrosis; Potassium; Pyrazines; Rats; Rats, Inbred F344; Risk | 1985 |
[Role of antikaliuretics and catecholamines in the prevention of cardiac necroses of metabolic origin].
Topics: Adrenal Cortex Hormones; Amiloride; Animals; Catecholamines; Digitoxin; Diuretics; Epinephrine; Heart Diseases; Kidney; Magnesium; Metabolic Diseases; Necrosis; Oils; Phenoxybenzamine; Potassium; Potassium Chloride; Propranolol; Pyrazines; Rats; Sodium; Stress, Physiological | 1971 |
Prevention of stress-induced cardiac necrosis by amiloride.
Topics: Animals; Diuretics; Ethacrynic Acid; Female; Heart Diseases; Hydrochlorothiazide; Immobilization; Myocardial Infarction; Necrosis; Potassium; Pyrazines; Rats; Stress, Physiological | 1969 |
Potassium, cardiac necroses and amiloride.
Topics: Animals; Blood Chemical Analysis; Diuretics; Female; Heart Diseases; Myocardium; Necrosis; Potassium; Pyrazines; Rats; Sodium; Steroids | 1970 |
Electrocardiographic alterations in metabolic cardiac necrosis and the influence of amiloride on these changes.
Topics: Acid-Base Equilibrium; Animals; Arrhythmias, Cardiac; Diuretics; Electrocardiography; Female; Heart; Heart Diseases; Heart Rate; Hydrogen-Ion Concentration; Hypernatremia; Hypocalcemia; Myocardium; Necrosis; Pyrazines; Rats; Water-Electrolyte Balance | 1970 |
Amiloride and the "electrolyte-eroid-cardiopathy with necrosis". Light and electron microscopic study of protective effects in rats.
Topics: Amides; Amidines; Animals; Coronary Vessels; Female; Fludrocortisone; Heart Diseases; Lipid Metabolism; Microscopy, Electron; Mitochondria, Muscle; Myocardium; Myofibrils; Necrosis; Oils; Phosphates; Pyrazines; Rats; Zea mays | 1969 |
Blood lipids in experimental cardiac necrosis.
Topics: Animals; Cholesterol; Diet; Diuretics; Fatty Acids, Nonesterified; Female; Heart; Heart Diseases; Lipids; Necrosis; Oils; Pyrazines; Rats; Triglycerides; Water-Electrolyte Balance; Zea mays | 1969 |