Page last updated: 2024-08-21

pyrazines and Necrosis

pyrazines has been researched along with Necrosis in 30 studies

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19908 (26.67)18.7374
1990's1 (3.33)18.2507
2000's10 (33.33)29.6817
2010's9 (30.00)24.3611
2020's2 (6.67)2.80

Authors

AuthorsStudies
Beylot-Barry, M; Protin, C; Recher, C; Sibaud, V; Vigarios, E; Ysebaert, L1
Lou, H; Ma, J; Shen, X; Sun, Q; Zhang, Q1
Adams, GP; Balachandran, S; Chen, P; Nogusa, S; Peri, S; Shaller, C; Simmons, H; Thapa, RJ1
Balachandran, S; Chen, P; Cheung, M; Nogusa, S; Pei, J; Peri, S; Testa, JR; Thapa, RJ1
Rouse, R; Stewart, S; Xu, L; Zhang, J1
Bailey, Z; Bolyard, C; Caligiuri, MA; Cripe, TP; Eaves, D; He, S; Hurwitz, BS; Kaur, B; Old, M; Parris, DS; Rath, KS; Selvendiran, K; Yoo, JY; Yu, J; Yu, JG; Zhang, J1
Ando, Y; Fujiwara, S; Hata, H; Iida, S; Kawano, Y; Kikukawa, Y; Mitsuya, H; Nakashima, T; Okuno, Y; Ri, M; Shiotsu, Y; Tasaki, M; Ueda, M; Wada, N; Yoshinaga, K1
Ide, S; Kojima, S; Nakanishi, Y; Nishino, K; Tanamachi, K; Tanuma, S; Tsukimoto, M1
Chao, B; Gao, AH; He, QJ; Hu, YH; Li, J; Ma, YM; Peng, YM; Zhou, YB; Zhu, QH1
Careddu, G; Carlo-Stella, C; Castagna, L; Locatelli, SL; Santoro, A; Stirparo, GG1
McConkey, DJ1
Brandes, G; Buer, J; Carlomagno, T; Frank, R; Geffers, R; Gossler, A; Gütgemann, I; Kalesse, M; Kubicka, S; Malek, NP; Manns, MP; Menche, D; Nickeleit, I; Sasse, F; Sörensen, I; Steinmetz, H; Zender, S1
Fels, DR; Koong, AC; Koumenis, C; Kridel, SJ; Olson, M; Segan, AT; Spiotto, M; Ye, J1
Bernardi, P; Brancolini, C; Crivellato, E; Demarchi, F; Fontanini, A; Foti, C; Maestro, R; Potu, H1
Brancolini, C; Demarchi, F; Foti, C1
Eller, K; Heininger, D; Huber, JM; Mayer, G; Rosenkranz, AR; Tagwerker, A1
Brancolini, C; Florean, C; Foti, C; Gustincich, S; Pezzutto, A; Roncaglia, P; Tomasella, A1
Bagot, M; Bezier, M; Cordoliani, F; Delyon, J; Malphettes, M; Rybojad, M; Szalat, R1
Anderson, KC; Bonham, L; Chauhan, D; Hideshima, H; Hideshima, T; Ishitsuka, K; Kumar, S; Mitsiades, C; Munshi, NC; Podar, K; Raje, N; Richardson, PG; Singer, JW; Yasui, H1
Cao, X; Cullen, MJ; Devenny, J; Hung, CP; Janovitz, E; Keim, WJ; Lehman-McKeeman, L; Malley, MF; Malmstrom, SE; Miller, KJ; Narayanan, R; Pelleymounter, MA; Qu, Q; Robl, JA; Rohrbach, KW; Rossi, K; Thomas, MA; Ung, T; Varnes, JG; Wacker, DA; Wu, G; Zhang, G; Zuvich, E1
Al-Moundhri, M; Al-Siyabi, S; Ali, BH; Annamalai, K; Eldin, MT; Nemmar, A1
Wang, XP; Xu, JY; Yuan, YZ1
Barrett, RJ; Harleman, JH; Joseph, EC1
Bennett, WM; Houghton, DC; Porter, GA; Purnell, J1
Savoie, LL1
Savoie, L; Selye, H; Somogyi, A1
Grinnell, E; Prioreschi, P; Sullivan, R1
Classen, HG; Solymoss, B; Varga, S2
Blascheck, JA; Gardell, C; Kovács, K1

Reviews

1 review(s) available for pyrazines and Necrosis

ArticleYear
Dermatological Toxicities of Bruton's Tyrosine Kinase Inhibitors.
    American journal of clinical dermatology, 2020, Volume: 21, Issue:6

    Topics: Adenine; Administration, Cutaneous; Agammaglobulinaemia Tyrosine Kinase; Benzamides; Biopsy; Drug Eruptions; Ecchymosis; Emollients; Humans; Incidence; Leukemia, Lymphocytic, Chronic, B-Cell; Necrosis; Patient Education as Topic; Piperidines; Protein Kinase Inhibitors; Pyrazines; Pyrazoles; Pyrimidines; Receptors, Antigen, B-Cell; Severity of Illness Index; Signal Transduction; Skin; Skin Care

2020

Other Studies

29 other study(ies) available for pyrazines and Necrosis

ArticleYear
Activation of Nrf2 signaling by oltipraz inhibits death of human macrophages with mycobacterium tuberculosis infection.
    Biochemical and biophysical research communications, 2020, 10-20, Volume: 531, Issue:3

    Topics: Apoptosis; Cytoprotection; Humans; Macrophages; Necrosis; NF-E2-Related Factor 2; Oxidative Stress; Pyrazines; Signal Transduction; Thiones; Thiophenes; Tuberculosis

2020
Anti-CD70 immunocytokines for exploitation of interferon-γ-induced RIP1-dependent necrosis in renal cell carcinoma.
    PloS one, 2013, Volume: 8, Issue:4

    Topics: Animals; Antiviral Agents; Boronic Acids; Bortezomib; Carcinoma, Renal Cell; CD27 Ligand; Cell Death; Cell Line, Tumor; Humans; Interferon-gamma; Kidney Neoplasms; Mice; Necrosis; Phosphorylation; Protein Binding; Pyrazines; Receptor-Interacting Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; Signal Transduction; Species Specificity; STAT1 Transcription Factor

2013
NF-κB inhibition by bortezomib permits IFN-γ-activated RIP1 kinase-dependent necrosis in renal cell carcinoma.
    Molecular cancer therapeutics, 2013, Volume: 12, Issue:8

    Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Carcinoma, Renal Cell; Cell Line, Tumor; Enzyme Activation; Humans; I-kappa B Kinase; Interferon-gamma; Kidney Neoplasms; Necrosis; NF-kappa B; Proteasome Inhibitors; Pyrazines; Receptor-Interacting Protein Serine-Threonine Kinases

2013
High fat diet and GLP-1 drugs induce pancreatic injury in mice.
    Toxicology and applied pharmacology, 2014, Apr-15, Volume: 276, Issue:2

    Topics: Acute Disease; Animals; Apoptosis; Atrophy; Diet, High-Fat; Exenatide; Glucagon-Like Peptide-1 Receptor; Hypoglycemic Agents; Male; Mice; Mice, Inbred C57BL; Necrosis; Pancreas; Pancreatitis; Peptides; Pyrazines; Receptors, Glucagon; Sitagliptin Phosphate; Triazoles; Venoms

2014
Bortezomib-induced unfolded protein response increases oncolytic HSV-1 replication resulting in synergistic antitumor effects.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, Jul-15, Volume: 20, Issue:14

    Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Line, Tumor; Combined Modality Therapy; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Female; Herpesvirus 1, Human; Humans; Mice, Nude; Necrosis; Oncolytic Virotherapy; Oncolytic Viruses; Pyrazines; Unfolded Protein Response; Virus Replication; Xenograft Model Antitumor Assays

2014
Shikonin, dually functions as a proteasome inhibitor and a necroptosis inducer in multiple myeloma cells.
    International journal of oncology, 2015, Volume: 46, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Death; Cell Line, Tumor; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Endoplasmic Reticulum Stress; Humans; Imidazoles; Indoles; Multiple Myeloma; Naphthoquinones; Necrosis; Proteasome Inhibitors; Purine Nucleosides; Pyrazines; Regulatory Factor X Transcription Factors; Transcription Factors; X-Box Binding Protein 1

2015
Radiosensitizing Effect of TRPV1 Channel Inhibitors in Cancer Cells.
    Biological & pharmaceutical bulletin, 2016, Jul-01, Volume: 39, Issue:7

    Topics: Acrylamides; Anilides; Animals; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cell Line, Tumor; Cell Survival; Cinnamates; DNA Damage; Gamma Rays; Humans; Mice; Necrosis; Neoplasms; Pyrazines; Pyridines; Radiation-Sensitizing Agents; TRPV Cation Channels

2016
Novel CHOP activator LGH00168 induces necroptosis in A549 human lung cancer cells via ROS-mediated ER stress and NF-κB inhibition.
    Acta pharmacologica Sinica, 2016, Volume: 37, Issue:10

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Endoplasmic Reticulum Stress; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Necrosis; NF-kappa B; Pyrazines; Pyrimidines; Reactive Oxygen Species

2016
Dual PI3K/ERK inhibition induces necroptotic cell death of Hodgkin Lymphoma cells through IER3 downregulation.
    Scientific reports, 2016, 10-21, Volume: 6

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Death; Cell Line, Tumor; Down-Regulation; Enzyme Inhibitors; Gene Expression; Hodgkin Disease; Humans; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Inbred NOD; Mice, SCID; Mitogen-Activated Protein Kinase Kinases; Necrosis; Phosphoinositide-3 Kinase Inhibitors; Pyrazines; Reactive Oxygen Species; RNA, Small Interfering; Xenograft Model Antitumor Assays

2016
A novel role for a familiar protein in apoptosis induced by proteasome inhibition.
    Cancer cell, 2008, Jul-08, Volume: 14, Issue:1

    Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Blood Vessels; Boronic Acids; Bortezomib; Cell Cycle; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Humans; Intracellular Signaling Peptides and Proteins; Necrosis; Neoplasms; Neovascularization, Pathologic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Pyrazines; Time Factors; Up-Regulation

2008
Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition.
    Cancer cell, 2008, Jul-08, Volume: 14, Issue:1

    Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Blood Vessels; Boronic Acids; Bortezomib; Cell Cycle; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; HCT116 Cells; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mice, Nude; Necrosis; Neoplasms; Neovascularization, Pathologic; Peptides, Cyclic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Pyrazines; RNA Interference; RNA, Small Interfering; Time Factors; Transfection; Up-Regulation; Xenograft Model Antitumor Assays

2008
Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways.
    Cancer research, 2008, Nov-15, Volume: 68, Issue:22

    Topics: Activating Transcription Factor 4; Antineoplastic Agents; Apoptosis; Autophagy; Boronic Acids; Bortezomib; Cell Hypoxia; Cell Line, Tumor; DNA-Binding Proteins; Endoplasmic Reticulum; Humans; Microtubule-Associated Proteins; Necrosis; Protease Inhibitors; Protein Folding; Pyrazines; Regulatory Factor X Transcription Factors; Signal Transduction; Stress, Physiological; Thapsigargin; Transcription Factors

2008
The Isopeptidase Inhibitor G5 Triggers a Caspase-independent Necrotic Death in Cells Resistant to Apoptosis: A COMPARATIVE STUDY WITH THE PROTEASOME INHIBITOR BORTEZOMIB.
    The Journal of biological chemistry, 2009, Mar-27, Volume: 284, Issue:13

    Topics: Actins; Animals; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-X Protein; Boronic Acids; Bortezomib; Carbon-Nitrogen Lyases; Cell Adhesion; Cell Line, Transformed; Collagen; Cyclosporine; Cytoskeleton; Extracellular Matrix; Fibronectins; HMGB1 Protein; MAP Kinase Kinase 4; Membrane Potential, Mitochondrial; Mice; Mice, Knockout; Necrosis; Peroxisome Proliferator-Activated Receptors; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrans; Pyrazines; Sulfhydryl Compounds

2009
Inhibitors of the ubiquitin-proteasome system are not all alike: identification of a new necrotic pathway.
    Autophagy, 2009, Volume: 5, Issue:4

    Topics: Animals; Autophagy; Boronic Acids; Bortezomib; Enzyme Inhibitors; Fibroblasts; Mice; Necrosis; Proteasome Endopeptidase Complex; Pyrazines; Ubiquitin

2009
The proteasome inhibitor bortezomib aggravates renal ischemia-reperfusion injury.
    American journal of physiology. Renal physiology, 2009, Volume: 297, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Boronic Acids; Bortezomib; CD4 Lymphocyte Count; Creatinine; Cyclin-Dependent Kinase Inhibitor p21; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intravenous; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Necrosis; Nephritis; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Reperfusion Injury; Time Factors

2009
Characterization of caspase-dependent and caspase-independent deaths in glioblastoma cells treated with inhibitors of the ubiquitin-proteasome system.
    Molecular cancer therapeutics, 2009, Volume: 8, Issue:11

    Topics: Apoptosis; Boronic Acids; Bortezomib; Caspases; Cell Death; Cell Line, Tumor; Gene Expression Profiling; Glioblastoma; Glutathione; Humans; Microarray Analysis; Necrosis; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyrans; Pyrazines; Sulfhydryl Compounds; Ubiquitin

2009
[Cutaneous manifestations revealing cryofibrinogenaemia associated with monoclonal gammopathy].
    Annales de dermatologie et de venereologie, 2013, Volume: 140, Issue:1

    Topics: Acute Kidney Injury; Adult; Aged, 80 and over; Anti-Inflammatory Agents; Antineoplastic Agents; Biopsy; Boronic Acids; Bortezomib; Cryoglobulinemia; Cryoglobulins; Cyclophosphamide; Dexamethasone; Drug Therapy, Combination; Female; Fibrinogens, Abnormal; Humans; Immunoglobulin kappa-Chains; Immunoglobulin lambda-Chains; Kidney; Leg Ulcer; Microscopy, Fluorescence; Necrosis; Paraproteinemias; Plasmapheresis; Prednisone; Pyrazines; Skin

2013
Molecular characterization of PS-341 (bortezomib) resistance: implications for overcoming resistance using lysophosphatidic acid acyltransferase (LPAAT)-beta inhibitors.
    Oncogene, 2005, Apr-28, Volume: 24, Issue:19

    Topics: Acyltransferases; Adenosine Triphosphate; Apoptosis; Apoptosis Regulatory Proteins; Boronic Acids; Bortezomib; Caspase 3; Caspase 8; Caspase 9; Caspases; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Flow Cytometry; G2 Phase; Humans; Immunoblotting; In Situ Nick-End Labeling; Multiple Myeloma; Necrosis; Phosphorylation; Poly(ADP-ribose) Polymerases; Protease Inhibitors; Proteasome Inhibitors; Proteins; Pyrazines; Time Factors; Treatment Outcome

2005
Discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a selective, orally active agonist of the 5-HT(2C) receptor.
    Journal of medicinal chemistry, 2007, Mar-22, Volume: 50, Issue:6

    Topics: Administration, Oral; Animals; Anti-Obesity Agents; Blood-Brain Barrier; Cell Line; Conditioning, Operant; Feeding Behavior; Humans; Indoles; Isoindoles; Male; Mice; Necrosis; Parietal Cells, Gastric; Pyrazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Serotonin 5-HT2 Receptor Agonists; Stereoisomerism; Weight Gain

2007
Amelioration of cisplatin-induced nephrotoxicity in rats by tetramethylpyrazine, a major constituent of the Chinese herb Ligusticum wallichi.
    Experimental biology and medicine (Maywood, N.J.), 2008, Volume: 233, Issue:7

    Topics: Animals; Antineoplastic Agents; Cisplatin; Creatinine; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Glutathione; Kidney; Ligusticum; Lipid Peroxidation; Male; Necrosis; Pyrazines; Rats; Rats, Wistar; Superoxide Dismutase; Urea

2008
[Therapeutic effects and mechanisms of tetramethylpyrazine on lung injury in acute haemorrhagic necrotizing pancreatitis in rats].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 1993, Volume: 13, Issue:10

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Free Radical Scavengers; Lipid Peroxides; Lung; Necrosis; Pancreatitis; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Thromboxane B2

1993
The evaluation of HBDH and LDH isoenzymes in cardiac cell necrosis of the rat.
    Journal of applied toxicology : JAT, 1988, Volume: 8, Issue:4

    Topics: Animals; Female; Heart; Humans; Hydroxybutyrate Dehydrogenase; Isoenzymes; Isoproterenol; L-Lactate Dehydrogenase; Male; Myocardium; Necrosis; Pyrazines; Rats; Rats, Inbred Strains; Tissue Distribution

1988
Effect of amiloride on experimental gentamicin nephrotoxicity.
    Nephron, 1985, Volume: 40, Issue:2

    Topics: Amiloride; Animals; Diet; Drug Interactions; Gentamicins; Inulin; Kidney; Kidney Cortex; Kidney Diseases; Kidney Tubules; Magnesium; Male; Necrosis; Potassium; Pyrazines; Rats; Rats, Inbred F344; Risk

1985
[Role of antikaliuretics and catecholamines in the prevention of cardiac necroses of metabolic origin].
    Pathologia Europaea, 1971, Volume: 6, Issue:4

    Topics: Adrenal Cortex Hormones; Amiloride; Animals; Catecholamines; Digitoxin; Diuretics; Epinephrine; Heart Diseases; Kidney; Magnesium; Metabolic Diseases; Necrosis; Oils; Phenoxybenzamine; Potassium; Potassium Chloride; Propranolol; Pyrazines; Rats; Sodium; Stress, Physiological

1971
Prevention of stress-induced cardiac necrosis by amiloride.
    Angiologica, 1969, Volume: 6, Issue:5

    Topics: Animals; Diuretics; Ethacrynic Acid; Female; Heart Diseases; Hydrochlorothiazide; Immobilization; Myocardial Infarction; Necrosis; Potassium; Pyrazines; Rats; Stress, Physiological

1969
Potassium, cardiac necroses and amiloride.
    European journal of pharmacology, 1970, Volume: 10, Issue:3

    Topics: Animals; Blood Chemical Analysis; Diuretics; Female; Heart Diseases; Myocardium; Necrosis; Potassium; Pyrazines; Rats; Sodium; Steroids

1970
Electrocardiographic alterations in metabolic cardiac necrosis and the influence of amiloride on these changes.
    Acta medica Academiae Scientiarum Hungaricae, 1970, Volume: 27, Issue:1

    Topics: Acid-Base Equilibrium; Animals; Arrhythmias, Cardiac; Diuretics; Electrocardiography; Female; Heart; Heart Diseases; Heart Rate; Hydrogen-Ion Concentration; Hypernatremia; Hypocalcemia; Myocardium; Necrosis; Pyrazines; Rats; Water-Electrolyte Balance

1970
Amiloride and the "electrolyte-eroid-cardiopathy with necrosis". Light and electron microscopic study of protective effects in rats.
    Archives of pathology, 1969, Volume: 88, Issue:2

    Topics: Amides; Amidines; Animals; Coronary Vessels; Female; Fludrocortisone; Heart Diseases; Lipid Metabolism; Microscopy, Electron; Mitochondria, Muscle; Myocardium; Myofibrils; Necrosis; Oils; Phosphates; Pyrazines; Rats; Zea mays

1969
Blood lipids in experimental cardiac necrosis.
    Canadian journal of physiology and pharmacology, 1969, Volume: 47, Issue:8

    Topics: Animals; Cholesterol; Diet; Diuretics; Fatty Acids, Nonesterified; Female; Heart; Heart Diseases; Lipids; Necrosis; Oils; Pyrazines; Rats; Triglycerides; Water-Electrolyte Balance; Zea mays

1969