Synaptojanin-1

A synaptojanin-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43426]

Synonyms

EC 3.1.3.36;
Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1

Research

Bioassay Publications (0)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0)	18.7374
1990's	0 (0)	18.2507
2000's	0 (0)	29.6817
2010's	0 (0)	24.3611
2020's	0 (0)	2.80

Compounds (7)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)
epicatechin gallate	Homo sapiens (human)	IC50	15.9000	2
ampelopsin	Homo sapiens (human)	IC50	15.9000	2
epiafzelechin	Homo sapiens (human)	IC50	15.9000	2
pyrvinium	Homo sapiens (human)	IC50	1.0000	2
trans-2,3',4,5'-tetrahydroxystilbene	Homo sapiens (human)	IC50	15.9000	2
chlorhexidine	Homo sapiens (human)	IC50	15.9000	2
eriodictyol 7-O-beta-D-glucopyranoside	Homo sapiens (human)	IC50	15.9000	2

Enables

This protein enables 11 target(s):

Target	Category	Definition
RNA binding	molecular function	Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]
phosphatidylinositol-3-phosphate phosphatase activity	molecular function	Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate. [EC:3.1.3.64]
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	molecular function	Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. [RHEA:22764]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
phosphatidylinositol phosphate 5-phosphatase activity	molecular function	Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate. [GOC:elh]
phosphatidylinositol phosphate 4-phosphatase activity	molecular function	Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate. [GOC:mah]
phosphatidylinositol-4-phosphate phosphatase activity	molecular function	Catalysis of the reaction: phosphatidyl-1D-myo-inositol-4-phosphate + H2O = phosphatidyl-1D-myo-inositol + phosphate. [PMID:10224048, RHEA:55652]
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	molecular function	Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate. [PMID:10806194, PMID:16607019, RHEA:32955]
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	molecular function	Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+. [PMID:19901554, RHEA:39019]
inositol-1,4,5-trisphosphate 5-phosphatase activity	molecular function	Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate. [EC:3.1.3.56, RHEA:19797]
SH3 domain binding	molecular function	Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. [GOC:go_curators, Pfam:PF00018]

Located In

This protein is located in 6 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
vesicle membrane	cellular component	The lipid bilayer surrounding any membrane-bounded vesicle in the cell. [GOC:mah, GOC:vesicle]
terminal bouton	cellular component	Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]
perinuclear region of cytoplasm	cellular component	Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid]
synaptic membrane	cellular component	A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. [GOC:BHF, PMID:20410104]
presynapse	cellular component	The part of a synapse that is part of the presynaptic cell. [GOC:dos]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
perinuclear region of cytoplasm	cellular component	Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid]
presynapse	cellular component	The part of a synapse that is part of the presynaptic cell. [GOC:dos]

Part Of

This protein is part of 2 target(s):

Target	Category	Definition
membrane coat	cellular component	Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. [GOC:mah]
clathrin coat of coated pit	cellular component	The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. [GOC:mah]

Involved In

This protein is involved in 13 target(s):

Target	Category	Definition
phosphatidylinositol biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. [ISBN:0198506732]
neurotransmitter transport	biological process	The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. [GOC:ai]
learning	biological process	Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience. [ISBN:0582227089, ISBN:0721662544]
synaptic vesicle priming	biological process	A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane. [GOC:mah, PMID:15217342, PMID:23060190]
synaptic vesicle uncoating	biological process	The removal of the protein coat on a synaptic vesicle following the pinching step at the end of budding from the presynaptic membrane. [GOC:curators, PMID:10099709, PMID:24596248]
phosphatidylinositol-3-phosphate biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position. [GOC:al, GOC:vw]
inositol phosphate metabolic process	biological process	The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. [GOC:jl]
phosphatidylinositol metabolic process	biological process	The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. [ISBN:0198506732]
phosphatidylinositol dephosphorylation	biological process	The process of removing one or more phosphate groups from a phosphatidylinositol. [ISBN:0198506732]
synaptic vesicle endocytosis	biological process	A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms. [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111]
synaptic vesicle transport	biological process	The directed movement of synaptic vesicles. [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:pr]
membrane organization	biological process	A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. [GOC:dph, GOC:tb]
positive regulation of endosome organization	biological process	Any process that activates or increases the frequency, rate or extent of endosome organization. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22511594]