DNA repair protein RAD52 homolog

A DNA repair protein RAD52 homolog that is encoded in the genome of human. [PRO:DNx]

Synonyms

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (100.00)	2.80

Compounds (17)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
aurintricarboxylic acid	Homo sapiens (human)	IC50	5.0000	1	1
gossypol	Homo sapiens (human)	IC50	5.0000	1	1
oxidopamine	Homo sapiens (human)	IC50	0.7790	1	0
1,2,5,8-tetrahydroxy anthraquinone	Homo sapiens (human)	IC50	3.0815	2	0
epigallocatechin gallate	Homo sapiens (human)	IC50	2.5108	5	1
epicatechin	Homo sapiens (human)	IC50	1.4500	1	0
gallocatechol	Homo sapiens (human)	IC50	2.9800	5	1
strictinin	Homo sapiens (human)	IC50	1.5000	1	1
corilagin	Homo sapiens (human)	IC50	1.0000	2	0
6-hydroxydopa	Homo sapiens (human)	IC50	1.1000	1	1
epicatechin gallate	Homo sapiens (human)	IC50	10.1275	2	0
asiatic acid	Homo sapiens (human)	IC50	450.0000	2	0
gossypetin	Homo sapiens (human)	IC50	3.4565	2	0
3-(4-chlorophenyl)-1-methyl-N-[3-(1-pyrrolidinyl)propyl]-5-thieno[2,3-c]pyrazolecarboxamide	Homo sapiens (human)	IC50	3.8000	2	0
cedrelone	Homo sapiens (human)	IC50	300.0000	1	0
rolitetracycline	Homo sapiens (human)	IC50	29.0000	1	0
methacycline monohydrochloride	Homo sapiens (human)	IC50	2.9000	2	0

Enables

This protein enables 4 target(s):

Target	Category	Definition
DNA binding	molecular function	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
single-stranded DNA binding	molecular function	Binding to single-stranded DNA. [GOC:elh, GOC:vw, PMID:22976174]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 2 target(s):

Target	Category	Definition
protein-containing complex	cellular component	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah]
protein-DNA complex	cellular component	A macromolecular complex containing both protein and DNA molecules. [GOC:mah]

Involved In

This protein is involved in 6 target(s):

Target	Category	Definition
DNA recombinase assembly	biological process	The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA. [PMID:10357855]
double-strand break repair	biological process	The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. [GOC:elh]
DNA recombination	biological process	Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. [ISBN:0198506732]
double-strand break repair via homologous recombination	biological process	The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. [GOC:elh, PMID:10357855]
mitotic recombination	biological process	The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous DNA region that occurs during mitotic cell cycles. [GOC:elh]
double-strand break repair via single-strand annealing	biological process	Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats. [PMID:11606529]