Page last updated: 2024-10-28

hypericin and Necrosis

hypericin has been researched along with Necrosis in 40 studies

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
" This study aimed to investigate the hypothesis that radioiodinated hypericin (131I-Hyp) may inhibit residual tumor recurrence after microwave ablation (MWA) on rat orthotopic liver allograft sarcoma models."7.83Improved therapeutic outcomes of thermal ablation on rat orthotopic liver allograft sarcoma models by radioiodinated hypericin induced necrosis targeted radiotherapy. ( Gao, L; Gao, M; Ma, T; Ni, Y; Shan, X; Shao, H; Xu, K; Yao, N; Zhang, J, 2016)
"Hypericin has an excellent necrosis-specific targeting capacity; thus, we explored small-molecular tumor necrosis therapy (SMTNT) for inhibiting tumor growth in rodent tumor models."7.81Biodistribution and anti-tumor efficacy of intratumorally injected necrosis-avid theranostic agent radioiodinated hypericin in rodent tumor models. ( Feng, Y; Gao, M; Huang, D; Jiang, C; Jiang, X; Jing, S; Li, Y; Liu, W; Ni, Y; Peng, F; Wang, X; Zhang, D; Zhang, J, 2015)
"We determined whether sodium cholate (NaCh) could act as a solubilizing agent for the necrosis avid iodine-123-labeled hypericin ((123)I-Hyp) and investigated biodistribution and targetability of this formulation in rabbits with acute myocardial infarction (AMI)."7.81Sodium cholate, a solubilizing agent for the necrosis avid radioiodinated hypericin in rabbits with acute myocardial infarction. ( Cona, MM; Feng, Y; Li, Y; Ni, Y; Oyen, R; Verbruggen, A; Zhang, J, 2015)
"Hypericin (HYP) has been found avid to necrosis in small animal studies."7.81Radiopharmaceutical study on Iodine-131-labelled hypericin in a canine model of hepatic RFA-induced coagulative necrosis. ( Ni, Y; Qi, X; Shao, H; Sun, Z; Xu, K; Zhang, J, 2015)
"The formulation of radioiodinated hypericin/hypericin appears crucial for its physical property, biodistribution, necrosis avidity and tumoricidal effects."7.80Radioiodinated hypericin: its biodistribution, necrosis avidity and therapeutic efficacy are influenced by formulation. ( Alpizar, YA; Bauwens, M; Chen, F; Cona, MM; de Witte, P; Feng, Y; Li, J; Ni, Y; Oyen, R; Sun, Z; Talavera, K; Verbruggen, A; Zhang, J, 2014)
"Hypericin (Hyp) is newly recognized as a necrosis avid agent, but its poor solubility imposes a great hindrance in clinical application."7.80Improvement of solubility and targetability of radioiodinated hypericin by using sodium cholate based solvent in rat models of necrosis. ( Cona, MM; Fang, Z; Gao, M; Ji, Y; Jiang, C; Jiang, X; Li, Y; Liu, W; Ni, Y; Sun, Z; Wang, J; Wang, Q; Wang, X; Yao, N; Yin, Z; Zhan, Y; Zhang, J, 2014)
"Hypericin, a potent necrosis avid agent, features a peculiar affinity for necrotic tissue."7.74Exploration of the mechanism underlying the tumor necrosis avidity of hypericin. ( De Witte, PA; Ni, Y; Van de Putte, M, 2008)
"Mono-[(123)I]iodohypericin ([(123)I]MIH) has been reported to have high avidity for necrosis."7.74Non-invasive detection and quantification of acute myocardial infarction in rabbits using mono-[123I]iodohypericin microSPECT. ( Bormans, G; Feng, Y; Fonge, H; Mortelmans, L; Ni, Y; Nuyts, J; Verbruggen, A; Vunckx, K; Wang, H, 2008)
"The results suggest that hypericin derivatives may serve as powerful necrosis-avid diagnostic agents for assessment of tissue viability."7.73First preclinical evaluation of mono-[123I]iodohypericin as a necrosis-avid tracer agent. ( Bormans, GM; Chen, F; de Witte, PA; Huyghe, D; Marchal, G; Mortelmans, L; Ni, Y; Nuyts, J; Verbeke, K; Verbruggen, AM, 2006)
"Photosensitization of HEC1-B cells with a low concentration of hypericin and doses of light below 10 J/cm(2) caused cell death (apoptosis occurred mainly at doses between 2 and 5 J/cm(2), whereas necrosis prevailed above 6 J/cm(2))."7.71Molecular aspects of photodynamic therapy: low energy pre-sensitization of hypericin-loaded human endometrial carcinoma cells enhances photo-tolerance, alters gene expression and affects the cell cycle. ( Coppola, E; Palumbo, G; Quarto, M; Varriale, L; Veneziani, BM, 2002)
"Here we report that photoactivated hypericin can induce either apoptosis or necrosis in HeLa cells."7.70Hypericin-induced photosensitization of HeLa cells leads to apoptosis or necrosis. Involvement of cytochrome c and procaspase-3 activation in the mechanism of apoptosis. ( Agostinis, P; Assefa, Z; Courtois, S; de Witte, P; Declercq, W; Merlevede, W; Vandenabeele, P; Vandenheede, JR; Vantieghem, A, 1998)
"Hypericin has been widely studied as a potent photosensitizer for photodynamic therapy in both preclinical and clinical settings."6.49Necrosis avidity: a newly discovered feature of hypericin and its preclinical applications in necrosis imaging. ( Chen, F; Jiang, B; Ni, Y; Wang, J, 2013)
"In conclusion, NTRT improved the anticancer efficacy of VDT in rabbits with VX2 tumors."5.42Necrosis targeted radiotherapy with iodine-131-labeled hypericin to improve anticancer efficacy of vascular disrupting treatment in rabbit VX2 tumor models. ( Chen, F; Dai, X; Li, Y; Ni, Y; Shao, H; Sun, Z; Xu, K; Zhang, J, 2015)
"Hypericin was radiolabeled with I using iodogen as oxidant, and (99m)Tc-Sestamibi was prepared from a commercial kit and radioactive sodium pertechnetate."5.39Comparative study of iodine-123-labeled hypericin and (99m)Tc-labeled hexakis [2-methoxy isobutyl isonitrile] in a rabbit model of myocardial infarction. ( Chen, F; Cona, MM; Feng, Y; Gheysens, O; Li, Y; Ni, Y; Nuyts, J; Oyen, R; Rezaei, A; Van Slambrouck, K; Verbruggen, A; Vunckx, K; Zhou, L, 2013)
" This would result in toxic melanin precursors (of an indolic and phenolic nature) leaking into the cytoplasm which in turn leads to cell death."5.35Hypericin phototoxicity induces different modes of cell death in melanoma and human skin cells. ( Davids, LM; Kacerovská, D; Kidson, SH; Kleemann, B; Pizinger, K, 2008)
"Necrosis was the principal mode of cell death despite different PDT doses and the absence of anti-apoptotic Bcl-2 expression, even if the same condition induced caspase-3 activity at similar toxicity in HeLa cells."5.34Necrosis predominates in the cell death of human colon adenocarcinoma HT-29 cells treated under variable conditions of photodynamic therapy with hypericin. ( Fedorocko, P; Hofmanová, J; Horváth, V; Jamborová, E; Kleban, J; Kozubík, A; Mikes, J; Sacková, V; Vaculová, A, 2007)
" This study aimed to investigate the hypothesis that radioiodinated hypericin (131I-Hyp) may inhibit residual tumor recurrence after microwave ablation (MWA) on rat orthotopic liver allograft sarcoma models."3.83Improved therapeutic outcomes of thermal ablation on rat orthotopic liver allograft sarcoma models by radioiodinated hypericin induced necrosis targeted radiotherapy. ( Gao, L; Gao, M; Ma, T; Ni, Y; Shan, X; Shao, H; Xu, K; Yao, N; Zhang, J, 2016)
"Hypericin has an excellent necrosis-specific targeting capacity; thus, we explored small-molecular tumor necrosis therapy (SMTNT) for inhibiting tumor growth in rodent tumor models."3.81Biodistribution and anti-tumor efficacy of intratumorally injected necrosis-avid theranostic agent radioiodinated hypericin in rodent tumor models. ( Feng, Y; Gao, M; Huang, D; Jiang, C; Jiang, X; Jing, S; Li, Y; Liu, W; Ni, Y; Peng, F; Wang, X; Zhang, D; Zhang, J, 2015)
"Hypericin (Hy) has shown great promise as a necrosis-avid agent in cancer imaging and therapy."3.81Evaluation of hypericin: effect of aggregation on targeting biodistribution. ( Gao, M; Huang, D; Ji, Y; Jiang, C; Li, Y; Liu, W; Liu, X; Ni, Y; Sun, Z; Yao, N; Yin, Z; Zhang, J, 2015)
"Hypericin (HYP) has been found avid to necrosis in small animal studies."3.81Radiopharmaceutical study on Iodine-131-labelled hypericin in a canine model of hepatic RFA-induced coagulative necrosis. ( Ni, Y; Qi, X; Shao, H; Sun, Z; Xu, K; Zhang, J, 2015)
"We determined whether sodium cholate (NaCh) could act as a solubilizing agent for the necrosis avid iodine-123-labeled hypericin ((123)I-Hyp) and investigated biodistribution and targetability of this formulation in rabbits with acute myocardial infarction (AMI)."3.81Sodium cholate, a solubilizing agent for the necrosis avid radioiodinated hypericin in rabbits with acute myocardial infarction. ( Cona, MM; Feng, Y; Li, Y; Ni, Y; Oyen, R; Verbruggen, A; Zhang, J, 2015)
"The formulation of radioiodinated hypericin/hypericin appears crucial for its physical property, biodistribution, necrosis avidity and tumoricidal effects."3.80Radioiodinated hypericin: its biodistribution, necrosis avidity and therapeutic efficacy are influenced by formulation. ( Alpizar, YA; Bauwens, M; Chen, F; Cona, MM; de Witte, P; Feng, Y; Li, J; Ni, Y; Oyen, R; Sun, Z; Talavera, K; Verbruggen, A; Zhang, J, 2014)
"Collar-induced carotid atherosclerosis ApoE knockout mice were imaged with (99m)Tc-AnxAF568 SPECT-CT to study apoptosis and sequentially with PET-CT following (124)I-Hypericin ((124)I-Hyp) injection to visualize necrosis."3.80In vivo molecular imaging of apoptosis and necrosis in atherosclerotic plaques using microSPECT-CT and microPET-CT imaging. ( Bauwens, M; Bucerius, J; De Saint-Hubert, M; Deckers, N; Douma, K; Drummen, M; Granton, P; Hendrikx, G; Kusters, D; Mottaghy, FM; Reutelingsperger, CP, 2014)
"To study the effect of co-injecting unlabelled hypericin (Hyp) on biodistribution, necrosis uptake and tumour retention of iodine-123 or iodine-131 labelled hypericin ((123/131)I-Hyp), a necrosis avid agent for an anticancer radiotherapy."3.80Targetability and biodistribution of radioiodinated hypericin: comparison between microdosing and carrier-added preparations. ( Chen, F; Cona, MM; Feng, Y; Li, J; Ni, Y; Oyen, R; Verbruggen, A; Witte, Pd, 2014)
"Hypericin (Hyp) is newly recognized as a necrosis avid agent, but its poor solubility imposes a great hindrance in clinical application."3.80Improvement of solubility and targetability of radioiodinated hypericin by using sodium cholate based solvent in rat models of necrosis. ( Cona, MM; Fang, Z; Gao, M; Ji, Y; Jiang, C; Jiang, X; Li, Y; Liu, W; Ni, Y; Sun, Z; Wang, J; Wang, Q; Wang, X; Yao, N; Yin, Z; Zhan, Y; Zhang, J, 2014)
"Significant differences in hypericin fluorescence were found in necrosis, viable tumor and normal liver tissue in decreasing order (P < ."3.74Hypericin as a marker for determination of tissue viability after intratumoral ethanol injection in a murine liver tumor model. ( Chen, F; de Witte, PA; Ni, Y; Van de Putte, M; Wang, H, 2008)
"Mono-[(123)I]iodohypericin ([(123)I]MIH) has been reported to have high avidity for necrosis."3.74Non-invasive detection and quantification of acute myocardial infarction in rabbits using mono-[123I]iodohypericin microSPECT. ( Bormans, G; Feng, Y; Fonge, H; Mortelmans, L; Ni, Y; Nuyts, J; Verbruggen, A; Vunckx, K; Wang, H, 2008)
"Hypericin, a potent necrosis avid agent, features a peculiar affinity for necrotic tissue."3.74Exploration of the mechanism underlying the tumor necrosis avidity of hypericin. ( De Witte, PA; Ni, Y; Van de Putte, M, 2008)
"In this proof-of-principle study, the necrosis avid agent hypericin was investigated as a potential indicator for early therapeutic response following radiofrequency ablation (RFA) of murine liver tumors."3.74Hypericin as a marker for determination of tissue viability after radiofrequency ablation in a murine liver tumor model. ( Chen, F; De Witte, PA; Ni, Y; Van de Putte, M; Wang, H, 2008)
"The results suggest that hypericin derivatives may serve as powerful necrosis-avid diagnostic agents for assessment of tissue viability."3.73First preclinical evaluation of mono-[123I]iodohypericin as a necrosis-avid tracer agent. ( Bormans, GM; Chen, F; de Witte, PA; Huyghe, D; Marchal, G; Mortelmans, L; Ni, Y; Nuyts, J; Verbeke, K; Verbruggen, AM, 2006)
"Photosensitization of HEC1-B cells with a low concentration of hypericin and doses of light below 10 J/cm(2) caused cell death (apoptosis occurred mainly at doses between 2 and 5 J/cm(2), whereas necrosis prevailed above 6 J/cm(2))."3.71Molecular aspects of photodynamic therapy: low energy pre-sensitization of hypericin-loaded human endometrial carcinoma cells enhances photo-tolerance, alters gene expression and affects the cell cycle. ( Coppola, E; Palumbo, G; Quarto, M; Varriale, L; Veneziani, BM, 2002)
"Here we report that photoactivated hypericin can induce either apoptosis or necrosis in HeLa cells."3.70Hypericin-induced photosensitization of HeLa cells leads to apoptosis or necrosis. Involvement of cytochrome c and procaspase-3 activation in the mechanism of apoptosis. ( Agostinis, P; Assefa, Z; Courtois, S; de Witte, P; Declercq, W; Merlevede, W; Vandenabeele, P; Vandenheede, JR; Vantieghem, A, 1998)
"Hypericin has been widely studied as a potent photosensitizer for photodynamic therapy in both preclinical and clinical settings."2.49Necrosis avidity: a newly discovered feature of hypericin and its preclinical applications in necrosis imaging. ( Chen, F; Jiang, B; Ni, Y; Wang, J, 2013)
" Their biodistribution and pharmacokinetic properties were determined in rat models of induced necrosis."1.43Effects of skeleton structure on necrosis targeting and clearance properties of radioiodinated dianthrones. ( Feng, Y; Gao, M; Huang, D; Jiang, C; Ni, Y; Shao, H; Sun, Z; Wang, X; Yang, S; Yin, Z; Zhang, D; Zhang, J, 2016)
"In conclusion, NTRT improved the anticancer efficacy of VDT in rabbits with VX2 tumors."1.42Necrosis targeted radiotherapy with iodine-131-labeled hypericin to improve anticancer efficacy of vascular disrupting treatment in rabbit VX2 tumor models. ( Chen, F; Dai, X; Li, Y; Ni, Y; Shao, H; Sun, Z; Xu, K; Zhang, J, 2015)
"Hypericin was radiolabeled with I using iodogen as oxidant, and (99m)Tc-Sestamibi was prepared from a commercial kit and radioactive sodium pertechnetate."1.39Comparative study of iodine-123-labeled hypericin and (99m)Tc-labeled hexakis [2-methoxy isobutyl isonitrile] in a rabbit model of myocardial infarction. ( Chen, F; Cona, MM; Feng, Y; Gheysens, O; Li, Y; Ni, Y; Nuyts, J; Oyen, R; Rezaei, A; Van Slambrouck, K; Verbruggen, A; Vunckx, K; Zhou, L, 2013)
"Hypericin was conjugated to biotin-ethylenediamine in a straightforward coupling method using n-hydroxysuccinimide and dicyclohexylcarbodiimide."1.38Pretargeting of necrotic tumors with biotinylated hypericin using 123I-labeled avidin: evaluation of a two-step strategy. ( Bauwens, M; Bormans, G; de Witte, P; Marysael, T; Ni, Y; Rozenski, J, 2012)
" This would result in toxic melanin precursors (of an indolic and phenolic nature) leaking into the cytoplasm which in turn leads to cell death."1.35Hypericin phototoxicity induces different modes of cell death in melanoma and human skin cells. ( Davids, LM; Kacerovská, D; Kidson, SH; Kleemann, B; Pizinger, K, 2008)
"Necrosis was the principal mode of cell death despite different PDT doses and the absence of anti-apoptotic Bcl-2 expression, even if the same condition induced caspase-3 activity at similar toxicity in HeLa cells."1.34Necrosis predominates in the cell death of human colon adenocarcinoma HT-29 cells treated under variable conditions of photodynamic therapy with hypericin. ( Fedorocko, P; Hofmanová, J; Horváth, V; Jamborová, E; Kleban, J; Kozubík, A; Mikes, J; Sacková, V; Vaculová, A, 2007)
" However, the tumors administered with a initial dose of CX at 24-h post-PDT had no tumor control."1.33Anti-angiogenic effects of Hypericin-photodynamic therapy in combination with Celebrex in the treatment of human nasopharyngeal carcinoma. ( Olivo, M; Soo, KC; Yee, KK, 2005)

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (5.00)18.2507
2000's15 (37.50)29.6817
2010's22 (55.00)24.3611
2020's1 (2.50)2.80

Authors

AuthorsStudies
Han, X1
Taratula, O2
Xu, K4
St Lorenz, A1
Moses, A1
Jahangiri, Y1
Yu, G1
Farsad, K1
Duan, X1
Yin, Z6
Jiang, C8
Jin, Q3
Zhang, D4
Sun, Z8
Ye, W1
Zhang, J13
Kong, M1
Jiang, X3
Li, Y8
Gao, M6
Yao, N4
Huang, D4
Wang, X4
Fang, Z2
Liu, W4
Ni, Y23
Cona, MM6
Feng, Y8
Chen, F8
Vunckx, K2
Zhou, L1
Van Slambrouck, K1
Rezaei, A1
Gheysens, O1
Nuyts, J3
Verbruggen, A7
Oyen, R4
Alpizar, YA1
Li, J5
Bauwens, M3
Talavera, K1
de Witte, P4
De Saint-Hubert, M2
Deckers, N1
Drummen, M1
Douma, K1
Granton, P1
Hendrikx, G1
Kusters, D1
Bucerius, J1
Reutelingsperger, CP1
Mottaghy, FM2
Jiang, B1
Wang, J2
Witte, Pd1
Ji, Y2
Zhan, Y1
Wang, Q3
Qi, X1
Shao, H4
Joniova, J1
Misuth, M1
Sureau, F1
Miskovsky, P1
Nadova, Z1
Liu, X1
Peng, F1
Jing, S1
Dai, X1
Yang, S3
Wang, C2
Song, S2
Chen, L1
Gao, L1
Ma, T1
Shan, X1
Prinsen, K1
Mortelmans, L3
Marysael, T3
Lerut, E1
Van de Putte, M4
Fonge, H2
Roskams, T1
Bormans, G3
de Witte, PA5
Rozenski, J1
Sharma, KV1
Davids, LM2
Du, HY2
Olivo, M4
Tan, BK1
Bay, BH2
Thong, PS1
Watt, F1
Ren, MQ1
Tan, PH1
Soo, KC2
Yee, KK1
Huyghe, D1
Verbeke, K1
Marchal, G1
Verbruggen, AM1
Bormans, GM1
Yip, GW1
Mikes, J1
Kleban, J1
Sacková, V1
Horváth, V1
Jamborová, E1
Vaculová, A1
Kozubík, A1
Hofmanová, J1
Fedorocko, P1
Wang, H3
Kleemann, B1
Kacerovská, D1
Pizinger, K1
Kidson, SH1
Vantieghem, A1
Assefa, Z1
Vandenabeele, P1
Declercq, W1
Courtois, S1
Vandenheede, JR1
Merlevede, W1
Agostinis, P1
Lavie, G1
Kaplinsky, C1
Toren, A1
Aizman, I1
Meruelo, D1
Mazur, Y1
Mandel, M1
Mirossay, A1
Mojzis, J1
Tóthová, J1
Hájiková, M1
Lacková, A1
Mirossay, L1
Paba, V1
Quarto, M2
Varriale, L2
Crescenzi, E1
Palumbo, G2
Coppola, E1
Veneziani, BM1

Reviews

2 reviews available for hypericin and Necrosis

ArticleYear
Necrosis avidity: a newly discovered feature of hypericin and its preclinical applications in necrosis imaging.
    Theranostics, 2013, Volume: 3, Issue:9

    Topics: Anthracenes; Humans; Necrosis; Optical Imaging; Perylene; Staining and Labeling

2013
Molecular imaging of cell death.
    Methods (San Diego, Calif.), 2009, Volume: 48, Issue:2

    Topics: Animals; Annexin A5; Anthracenes; Antibodies, Monoclonal; Apoptosis; Bacteriocins; Cell Death; Gluca

2009

Other Studies

38 other studies available for hypericin and Necrosis

ArticleYear
Biodegradable Hypericin-Containing Nanoparticles for Necrosis Targeting and Fluorescence Imaging.
    Molecular pharmaceutics, 2020, 05-04, Volume: 17, Issue:5

    Topics: Animals; Anthracenes; Cell Line, Tumor; Female; Humans; Mice; Nanoparticles; Necrosis; Neoplasms; Op

2020
Radioiodinated hypericin disulfonic acid sodium salts as a DNA-binding probe for early imaging of necrotic myocardium.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2017, Volume: 117

    Topics: Animals; Anthracenes; Cattle; Cell Line; Cell Survival; DNA; Heart; Iodine Radioisotopes; Male; Mice

2017
Necrosis affinity evaluation of 131I-hypericin in a rat model of induced necrosis.
    Journal of drug targeting, 2013, Volume: 21, Issue:6

    Topics: Animals; Anthracenes; Area Under Curve; Half-Life; Iodine Isotopes; Isotope Labeling; Male; Necrosis

2013
Comparative study of iodine-123-labeled hypericin and (99m)Tc-labeled hexakis [2-methoxy isobutyl isonitrile] in a rabbit model of myocardial infarction.
    Journal of cardiovascular pharmacology, 2013, Volume: 62, Issue:3

    Topics: Animals; Anthracenes; Autoradiography; Coronary Circulation; Coronary Vessels; Disease Models, Anima

2013
Radioiodinated hypericin: its biodistribution, necrosis avidity and therapeutic efficacy are influenced by formulation.
    Pharmaceutical research, 2014, Volume: 31, Issue:2

    Topics: Animals; Anthracenes; Antineoplastic Agents; Chemistry, Pharmaceutical; Dimethyl Sulfoxide; Iodine R

2014
In vivo molecular imaging of apoptosis and necrosis in atherosclerotic plaques using microSPECT-CT and microPET-CT imaging.
    Molecular imaging and biology, 2014, Volume: 16, Issue:2

    Topics: Animals; Annexin A5; Anthracenes; Apoptosis; Humans; Mice; Molecular Imaging; Multimodal Imaging; Ne

2014
Targetability and biodistribution of radioiodinated hypericin: comparison between microdosing and carrier-added preparations.
    Anti-cancer agents in medicinal chemistry, 2014, Volume: 14, Issue:6

    Topics: Animals; Anthracenes; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Carriers; Fi

2014
Improvement of solubility and targetability of radioiodinated hypericin by using sodium cholate based solvent in rat models of necrosis.
    Journal of drug targeting, 2014, Volume: 22, Issue:4

    Topics: Animals; Anthracenes; Disease Models, Animal; Iodine Radioisotopes; Liver; Magnetic Resonance Imagin

2014
Sodium cholate, a solubilizing agent for the necrosis avid radioiodinated hypericin in rabbits with acute myocardial infarction.
    Drug delivery, 2015, Volume: 22, Issue:3

    Topics: Animals; Anthracenes; Autoradiography; Disease Models, Animal; Gamma Cameras; Heart; Iodine Radioiso

2015
Radiopharmaceutical study on Iodine-131-labelled hypericin in a canine model of hepatic RFA-induced coagulative necrosis.
    La Radiologia medica, 2015, Volume: 120, Issue:2

    Topics: Animals; Anthracenes; Catheter Ablation; Dogs; Liver; Male; Necrosis; Perylene; Radiopharmaceuticals

2015
Effect of PKCα expression on Bcl-2 phosphorylation and cell death by hypericin.
    Apoptosis : an international journal on programmed cell death, 2014, Volume: 19, Issue:12

    Topics: Anthracenes; Apoptosis; Cell Line, Tumor; Cell Survival; Gene Expression; Humans; Mitochondria; Necr

2014
Evaluation of hypericin: effect of aggregation on targeting biodistribution.
    Journal of pharmaceutical sciences, 2015, Volume: 104, Issue:1

    Topics: Animals; Anthracenes; Antineoplastic Agents, Phytogenic; Autoradiography; Dimethyl Sulfoxide; Drug C

2015
Biodistribution and anti-tumor efficacy of intratumorally injected necrosis-avid theranostic agent radioiodinated hypericin in rodent tumor models.
    Journal of drug targeting, 2015, Volume: 23, Issue:4

    Topics: Animals; Anthracenes; Antineoplastic Agents; Autoradiography; Carcinoma, Hepatocellular; Cell Line,

2015
Necrosis targeted radiotherapy with iodine-131-labeled hypericin to improve anticancer efficacy of vascular disrupting treatment in rabbit VX2 tumor models.
    Oncotarget, 2015, Jun-10, Volume: 6, Issue:16

    Topics: Animals; Anthracenes; Autoradiography; Disease Models, Animal; Iodine Radioisotopes; Necrosis; Neopl

2015
Synthesis and Preclinical Evaluation of Radioiodinated Hypericin Dicarboxylic Acid as a Necrosis Avid Agent in Rat Models of Induced Hepatic, Muscular, and Myocardial Necroses.
    Molecular pharmaceutics, 2016, Jan-04, Volume: 13, Issue:1

    Topics: Animals; Anthracenes; Iodine Radioisotopes; Liver; Muscle, Skeletal; Myocardial Infarction; Myocardi

2016
Effects of skeleton structure on necrosis targeting and clearance properties of radioiodinated dianthrones.
    Journal of drug targeting, 2016, Volume: 24, Issue:6

    Topics: Animals; Anthracenes; Cell Line, Tumor; Disease Models, Animal; Drug Delivery Systems; Drug Design;

2016
Discovery of Radioiodinated Monomeric Anthraquinones as a Novel Class of Necrosis Avid Agents for Early Imaging of Necrotic Myocardium.
    Scientific reports, 2016, Feb-16, Volume: 6

    Topics: Animals; Anthracenes; Anthraquinones; Chromatography, High Pressure Liquid; Iodine Radioisotopes; Ma

2016
Improved therapeutic outcomes of thermal ablation on rat orthotopic liver allograft sarcoma models by radioiodinated hypericin induced necrosis targeted radiotherapy.
    Oncotarget, 2016, Aug-09, Volume: 7, Issue:32

    Topics: Allografts; Animals; Anthracenes; Cell Line, Tumor; Combined Modality Therapy; Hyperthermia, Induced

2016
Influence of the vascular damaging agents DMXAA and ZD6126 on hypericin distribution and accumulation in RIF-1 tumors.
    Journal of cancer research and clinical oncology, 2011, Volume: 137, Issue:11

    Topics: Animals; Anthracenes; Antineoplastic Agents; Cell Line, Tumor; Mice; Mice, Inbred C3H; Necrosis; Neo

2011
Radiolabeled iodohypericin as tumor necrosis avid tracer: diagnostic and therapeutic potential.
    International journal of cancer, 2012, Jul-15, Volume: 131, Issue:2

    Topics: Animals; Anthracenes; Autoradiography; Female; Fibrosarcoma; Fluorodeoxyglucose F18; Mice; Mice, Inb

2012
Pretargeting of necrotic tumors with biotinylated hypericin using 123I-labeled avidin: evaluation of a two-step strategy.
    Investigational new drugs, 2012, Volume: 30, Issue:6

    Topics: Animals; Anthracenes; Antineoplastic Agents; Avidin; Biotin; Biotinylation; Cell Line, Tumor; Contra

2012
Hypericin-PDT-induced rapid necrotic death in human squamous cell carcinoma cultures after multiple treatment.
    Cell biology international, 2012, Volume: 36, Issue:12

    Topics: Anthracenes; Carcinoma, Squamous Cell; Cell Line, Tumor; Humans; Hypericum; Necrosis; Perylene; Phot

2012
Hypericin-mediated photodynamic therapy induces lipid peroxidation and necrosis in nasopharyngeal cancer.
    International journal of oncology, 2003, Volume: 23, Issue:5

    Topics: Animals; Anthracenes; Antioxidants; Apoptosis; Cell Line, Tumor; Cytoplasm; Humans; Light; Lipid Per

2003
Hypericin-photodynamic therapy (PDT) using an alternative treatment regime suitable for multi-fraction PDT.
    Journal of photochemistry and photobiology. B, Biology, 2006, Jan-02, Volume: 82, Issue:1

    Topics: Animals; Anthracenes; Apoptosis; Calcium; Immunohistochemistry; Light; Mice; Mice, Inbred BALB C; Mi

2006
Anti-angiogenic effects of Hypericin-photodynamic therapy in combination with Celebrex in the treatment of human nasopharyngeal carcinoma.
    International journal of molecular medicine, 2005, Volume: 16, Issue:6

    Topics: Angiogenesis Inhibitors; Animals; Anthracenes; Celecoxib; Cyclooxygenase 2; Drug Therapy, Combinatio

2005
First preclinical evaluation of mono-[123I]iodohypericin as a necrosis-avid tracer agent.
    European journal of nuclear medicine and molecular imaging, 2006, Volume: 33, Issue:5

    Topics: Animals; Anthracenes; Drug Evaluation, Preclinical; Heart; Liver; Metabolic Clearance Rate; Myocardi

2006
Differential up-regulation of metallothionein isoforms in well-differentiated nasopharyngeal cancer cells in vitro by photoactivated hypericin.
    Oncology reports, 2006, Volume: 16, Issue:6

    Topics: Anthracenes; Flow Cytometry; Humans; In Vitro Techniques; Metallothionein; Nasopharyngeal Neoplasms;

2006
Necrosis predominates in the cell death of human colon adenocarcinoma HT-29 cells treated under variable conditions of photodynamic therapy with hypericin.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2007, Volume: 6, Issue:7

    Topics: Adenocarcinoma; Anthracenes; Caspase 3; Cell Cycle; Cell Proliferation; Colonic Neoplasms; Dose-Resp

2007
Hypericin as a marker for determination of tissue viability after intratumoral ethanol injection in a murine liver tumor model.
    Academic radiology, 2008, Volume: 15, Issue:1

    Topics: Analysis of Variance; Animals; Anthracenes; Antineoplastic Agents; Disease Models, Animal; Ethanol;

2008
Non-invasive detection and quantification of acute myocardial infarction in rabbits using mono-[123I]iodohypericin microSPECT.
    European heart journal, 2008, Volume: 29, Issue:2

    Topics: Animals; Anthracenes; Disease Models, Animal; Drug Evaluation, Preclinical; Heart; Iodine Radioisoto

2008
Hypericin phototoxicity induces different modes of cell death in melanoma and human skin cells.
    Journal of photochemistry and photobiology. B, Biology, 2008, May-29, Volume: 91, Issue:2-3

    Topics: Anthracenes; Apoptosis; Caspase 3; Caspase 7; Cell Death; Cell Line, Tumor; Cell Survival; Humans; I

2008
Exploration of the mechanism underlying the tumor necrosis avidity of hypericin.
    Oncology reports, 2008, Volume: 19, Issue:4

    Topics: Animals; Anthracenes; Carbocyanines; Female; Fibrosarcoma; Lipoproteins; Mice; Mice, Inbred C3H; Nec

2008
Hypericin as a marker for determination of tissue viability after radiofrequency ablation in a murine liver tumor model.
    Oncology reports, 2008, Volume: 19, Issue:4

    Topics: Animals; Anthracenes; Biomarkers; Catheter Ablation; Female; Liver Neoplasms, Experimental; Mice; Mi

2008
Hypericin-induced photosensitization of HeLa cells leads to apoptosis or necrosis. Involvement of cytochrome c and procaspase-3 activation in the mechanism of apoptosis.
    FEBS letters, 1998, Nov-27, Volume: 440, Issue:1-2

    Topics: Amino Acid Chloromethyl Ketones; Anthracenes; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Ce

1998
A photodynamic pathway to apoptosis and necrosis induced by dimethyl tetrahydroxyhelianthrone and hypericin in leukaemic cells: possible relevance to photodynamic therapy.
    British journal of cancer, 1999, Volume: 79, Issue:3-4

    Topics: Anthracenes; Apoptosis; bcl-2-Associated X Protein; Cell Nucleus; DNA, Neoplasm; Dose-Response Relat

1999
Hypocrellin and hypericin-induced phototoxicity of HL-60 cells: apoptosis or necrosis?
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2000, Volume: 7, Issue:6

    Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Drugs, Chinese Herbal; HL-60 Cells; Humans; Necrosis;

2000
Photo-activation of hypericin with low doses of light promotes apparent photo-resistance in human histiocytic lymphoma U937 cells.
    Journal of photochemistry and photobiology. B, Biology, 2001, Volume: 60, Issue:2-3

    Topics: Anthracenes; Apoptosis; Cell Death; Dose-Response Relationship, Radiation; Drug Resistance, Neoplasm

2001
Molecular aspects of photodynamic therapy: low energy pre-sensitization of hypericin-loaded human endometrial carcinoma cells enhances photo-tolerance, alters gene expression and affects the cell cycle.
    FEBS letters, 2002, Feb-13, Volume: 512, Issue:1-3

    Topics: Anthracenes; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Biological Transport; Carcinoma;

2002