Cystathionine gamma-lyase

A cystathionine gamma-lyase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P32929]

Synonyms

EC 4.4.1.1;
Cysteine-protein sulfhydrase;
Gamma-cystathionase

Research

Bioassay Publications (4)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	4 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (15)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
aminooxyacetic acid	Homo sapiens (human)	IC50	2.2850	2	2
salicylic acid	Homo sapiens (human)	IC50	200.0000	1	1
aurintricarboxylic acid	Homo sapiens (human)	IC50	94.5000	10	10
aurintricarboxylic acid	Homo sapiens (human)	Ki	0.6000	1	1
mesalamine	Homo sapiens (human)	IC50	200.0000	1	1
penicillamine	Homo sapiens (human)	IC50	270.0000	1	1
nitroxoline	Homo sapiens (human)	IC50	8.2333	3	3
olsalazine	Homo sapiens (human)	IC50	200.0000	1	1
methyldopa	Homo sapiens (human)	IC50	3,000.0000	1	1
6-amino-7-chloro-5,8-dioxoquinoline	Homo sapiens (human)	IC50	50.0000	1	1
kalafungin	Homo sapiens (human)	IC50	50.0000	1	1
nsc228155	Homo sapiens (human)	IC50	50.0000	1	1
agathisflavone	Homo sapiens (human)	IC50	400.0000	1	1
cupressuflavone	Homo sapiens (human)	IC50	400.0000	1	1
podocarpusflavone a	Homo sapiens (human)	IC50	400.0000	1	1
aminoethoxyvinylglycine	Homo sapiens (human)	IC50	1.1000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
aurintricarboxylic acid	Homo sapiens (human)	Kd	3.4000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
aurintricarboxylic acid	Homo sapiens (human)	alphaKi	4.2000	1	1

Enables

This protein enables 9 target(s):

Target	Category	Definition
cystathionine gamma-lyase activity	molecular function	Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+. [RHEA:14005]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
calmodulin binding	molecular function	Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. [GOC:krc]
pyridoxal phosphate binding	molecular function	Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. [GOC:mah, ISBN:0198506732]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
L-cystine L-cysteine-lyase (deaminating)	molecular function	Catalysis of the reaction: L-cystine + H2O = pyruvate + NH3 + thiocysteine. Thiocysteine is also known as cysteine persulfide. [GOC:jl, RHEA:24927]
homocysteine desulfhydrase activity	molecular function	Catalysis of the reaction: L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate. [EC:4.4.1.2, MetaCyc:HOMOCYSTEINE-DESULFHYDRASE-RXN]
L-cysteine desulfhydrase activity	molecular function	Catalysis of the reaction: L-cysteine + H2O = ammonia + pyruvate + hydrogen sulfide + H+. [MetaCyc:LCYSDESULF-RXN, PMID:19955263]
selenocystathionine gamma-lyase activity	molecular function	Catalysis of the reaction: L-Selenocystathionine + H2O => L-Selenocysteine + NH3 + 2-Oxobutanoic acid. [PMID:6456763]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 14 target(s):

Target	Category	Definition
cysteine metabolic process	biological process	The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid. [GOC:go_curators]
lipid metabolic process	biological process	The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. [GOC:ma]
protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine	biological process	The modification of peptidyl-lysine to form N6-pyridoxal phosphate-L-lysine. [RESID:AA0119]
cysteine biosynthetic process via cystathionine	biological process	The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine. [GOC:go_curators]
cysteine biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. [GOC:go_curators]
transsulfuration	biological process	The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes. [MetaCyc:PWY-801]
endoplasmic reticulum unfolded protein response	biological process	The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation. [GOC:mah, PMID:12042763]
positive regulation of canonical NF-kappaB signal transduction	biological process	Any process that activates or increases the frequency, rate or extent of a canonical NF-kappaB signaling cascade. [GOC:jl]
protein sulfhydration	biological process	The modification of a protein amino acid by the addition of sulfur. [GOC:jl, GOC:jsg, PMID:19903941, PMID:22169477, PMID:8161529]
protein homotetramerization	biological process	The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. [GOC:go_curators]
hydrogen sulfide biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S. [GOC:mah]
positive regulation of aortic smooth muscle cell differentiation	biological process	Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194]
cellular response to leukemia inhibitory factor	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus. [PMID:12801913]
negative regulation of apoptotic signaling pathway	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway. [GOC:mtg_apoptosis]