Arsenic: A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 5359596 |
| CHEMBL ID | 1231052 |
| CHEBI ID | 27563 |
| CHEBI ID | 35826 |
| MeSH ID | M0001723 |
| Synonym |
|---|
| einecs 231-148-6 |
| arsenic-75 |
| ccris 55 |
| gray arsenic |
| arsenicals |
| hsdb 509 |
| colloidal arsenic |
| CHEMBL1231052 |
| arsenic hydride (ash3) |
| un2188 |
| hsdb 510 |
| agent sa |
| einecs 232-066-3 |
| arsenic |
| C06269 |
| 7440-38-2 |
| AS , |
| arsenic, powder, >=99.997% trace metals basis |
| arsenic, 99.999% trace metals basis |
| arsenic, inorganic |
| arsenic 75 |
| arsenico |
| arsenic atom |
| 33as |
| arsenicum |
| CHEBI:27563 , |
| arsen |
| ec 232-066-3 |
| arsenowodor |
| arsine [un2188] [poison gas] |
| unii-v1i29r0rjq |
| v1i29r0rjq , |
| inorganic arsenic |
| unii-n712m78a8g |
| n712m78a8g , |
| arsenicum metallicum |
| AKOS015902733 |
| arsine [mi] |
| RQNWIZPPADIBDY-UHFFFAOYSA-N |
| FT-0696579 |
| DTXSID3023760 |
| arsenic polycrystalline lump, 2-8mm (0.08-0.3in), 99.9999% (metals basis) |
| arsenic polycrystalline lump, 2-8mm (0.08-0.3in), 99.99999% (metals basis) |
| arsenic, >=99.999%, pieces |
| DTXSID4023886 , |
| Q21060492 |
| arsenic, lump |
| arsenic metal |
| arsenic sponge |
| arsenic hollow cathode lamp: 1.5 diameter, 2-pin, non-coded |
| arsenic hollow cathode lamp: 2.0 diameter, 4-pin, cableless |
| arsenic hollow cathode lamp: 2.0 diameter, 9-pin, non-coded |
| arsino |
| DTXSID201080837 |
| DTXSID501080836 |
| arsinidene |
| 14 - agricultural soil inorganics |
| 104 - saline water - metals |
| arsenic aa standard: as @ 1000 microg/ml in 5% hno3 |
| arsenic standard: as @ 1000 microg/ml in 5% hno3 |
| 14 - elemental contamination in herbal supplement |
| arsenic standard: as @ 10000 microg/ml in 5% hno3 |
| aq-14-qc sample 14 - agricultural soil inorganics and specific elements |
| 02 - sample 2 cane/beet sugar |
| 19 - lipstick |
| 21 - powder sample |
| 20 - lip gloss sample |
| arsenic standard: as @ 1000 microg/g in hydrocarbon oil |
| various lead alloy, 50g chips |
| s36 - organic fertilizer |
| 2 - minerals and elements in animal feed |
| 8 - minerals and trace elements in premix materials |
| arsenicals; arsenic, inorganic; arsen |
| 13 - sewage sludge inorganics |
| 62 - saline water - metals |
| 04 - elements |
| arsenic standard: as @ 10 microg/ml in 2% hno3 |
| 17 - elemental contamination in pollen supplement |
| 2b - trace elements |
| arsenic metal: arsenia |
| arsenic, (solid) |
| dtxcid703886 |
| arsenic, metallic |
| arsenic and inorganic arsenic compounds (iarc) |
| arsenic, solid |
| chebi:35826 |
| arsenic - as @ 1000 microg/ml in 5% hno3 |
| arsenic standard: 1000 microg/g as in 75 cst hydrocarbon oil |
An aquatic midge raised in metal-contaminated field sediments was tested for toxic response to arsenic exposure. Exposure to arsenic through contaminated food and drinking water is an important public health burden worldwide. Data show that arsenic-protein interactions affect multiple cellular processes.
| Excerpt | Reference | Relevance |
|---|---|---|
| " Furthermore, individual differences which are caused by genetic, nutritional, hormonal, habitual, and many other factors may alter the toxic or metabolic effects of a single metal." | ( [Various factors influencing toxicity and metabolism of metals--metal-metal interactions and host factors (author's transl)]. Tsuchiya, K, 1977) | 0.26 |
| " Finally, we suggest that arsenic has a direct toxic effect on DNA synthesis that results in marked disturbances of nuclear division." | ( Arsenic-induced bone marrow toxicity: ultrastructural and electron-probe analysis. Bredehoeft, S; Cohen, HJ; Feussner, JR; Shelburne, JD, 1979) | 0.26 |
| " BAL given following arsenite was not able to ameliorate the developmentally toxic effects of arsenite seen in mice, whereas treatment with DMPS at 150 and 300 mg/kg showed significant protective effects against arsenite embryotoxicity and teratogenicity." | ( Amelioration by BAL (2,3-dimercapto-1-propanol) and DMPS (sodium 2,3-dimercapto-1-propanesulfonic acid) of arsenite developmental toxicity in mice. Bosque, MA; Corbella, J; Domingo, JL; Llobet, JM, 1992) | 0.28 |
| " Nonetheless, preinduction of heat shock proteins was associated with protection from toxic concentrations of glutamate." | ( The stress protein response in cultured neurons: characterization and evidence for a protective role in excitotoxicity. Chan, PH; Lowenstein, DH; Miles, MF, 1991) | 0.28 |
| "Previously, we had shown that arsenic interacts with cadmium in rats; our results showed that the toxicity of a mixture of arsenic + cadmium cannot be predicted by the toxic mechanisms of the individual components." | ( Arsenic-cadmium interaction in rats: toxic effects in the heart and tissue metal shifts. Batres, L; Carrizales, L; Díaz-Barriga, F; Mejía, JJ; Yáñez, L; Zanatta, MT, 1991) | 0.28 |
| " Instead of using death as the principal criterion of toxicity, it is based on a careful, standardized clinical assessment of toxic signs measured in the nonlethal dose range." | ( Acute toxicity testing in the nonlethal dose range: a new approach. Sigg, H; Tamborini, P; Zbinden, G, 1990) | 0.28 |
| "Trimethylarsine (TM-As) proved to be an arsenic compound of low toxicity, with a po LD50 of 7870 mg/kg in mice." | ( Toxicity and metabolism of trimethylarsine in mice and hamsters. Kaise, T; Takahashi, K; Yamamura, Y; Yamauchi, H, 1990) | 0.28 |
| " The only side-effect was of transient thrombocytosis in a single patient." | ( Safety and efficacy of acetarsol suppositories in unresponsive proctitis. Britton, TC; Forbes, A; Gazzard, BG; House, IM, 1989) | 0.28 |
| "Studies of marginal safe Se-intake have been carried out in a seleniferous section of China since 1985." | ( Studies of safe maximal daily dietary selenium intake in a seleniferous area in China. I. Selenium intake and tissue selenium levels of the inhabitants. Gu, L; Li, X; Liu, Y; Yan, B; Yang, G; Yin, S; Zhou, R, 1989) | 0.28 |
| " G1-phase CHO cells showed a 2-fold increase in the susceptibility to the toxic effects of sodium arsenite as compared to asynchronous CHO cells." | ( Differential cytotoxicity of sodium arsenite in human fibroblasts and Chinese hamster ovary cells. Jan, KY; Ko, JL; Lee, TC, 1989) | 0.28 |
| " Toxic manifestations in man occur at the cellular level and may appear in many organ systems." | ( Clinical and environmental aspects of arsenic toxicity. Hindmarsh, JT; McCurdy, RF, 1986) | 0.27 |
| " The compounds also exhibited toxicity; however, transformation was observed at non-toxic as well as toxic doses." | ( Comparison of arsenic-induced cell transformation, cytotoxicity, mutation and cytogenetic effects in Syrian hamster embryo cells in culture. Barrett, JC; Lee, TC; Oshimura, M, 1985) | 0.27 |
| " Lead nitrate was the most toxic salt but was genetically inactive." | ( Genotoxic effects of potassium dichromate, sodium arsenite, cobalt chloride and lead nitrate in diploid yeast. Kharab, P; Singh, I, 1985) | 0.27 |
| " Cells pretreated with a low As(III) concentration are less sensitive to toxic doses of As(III) or As(V)." | ( Arsenic uptake, cytotoxicity and detoxification studied in mammalian cells in culture. Buchet, JP; Fischer, AB; Lauwerys, RR, 1985) | 0.27 |
| " Survival time was prolonged in rats treated with the toxic metals by pretreatment with NKK-105." | ( Effects of diiospropyl-1,3-dithiol-2-ylidene malonate (NKK-105) on acute toxicity of various drugs and heavy metals. Hosokawa, T; Kitagawa, H; Saito, H; Sakamoto, K; Sugimoto, T; Yanaura, S, 1982) | 0.26 |
| " L-cysteine x HCl x H2O (59%) increased rate and efficiency of gain when added to the basal diet, but depressed performance, increased kidney arsenic concentration, and enhanced mortality when added to diets containing toxic levels of roxarsone (200 mg/kg or higher)." | ( Roxarsone toxicity in the chick as influenced by dietary cysteine and copper and by experimental infection with Eimeria acervulina. Baker, DH; Czarnecki, GL, 1982) | 0.26 |
| "The authors consider evident similarities of toxic effects in the treatment of human african trypanosomiasis with Arsobal, and those in the treatment of syphilis with arsenobenzole derivatives." | ( [Adrenaline in the prevention and treatment of adverse effects of arsobal therapy. Apropos of 776 cases of human African trypanosomiasis caused by T. gambiense in the Health Service of Fontem (U.R. Cameroon)]. Cramet, B; Sina, GC; Suh Bandu, M; Triolo, N, ) | 0.13 |
| " Arsenic III, the most toxic compound, caused a significant reduction in the survival of amphipods at 1000 microgram As/L after seven days." | ( Comparative toxicity of arsenic compounds and their accumulation in invertebrates and fish. Anderson, RL; DeFoe, DL; Fiandt, JT; Spehar, RL, 1980) | 0.26 |
| " The order of toxicity of the arsenic compounds to the worms was PDA > arsenite > arsenate (24 h LD50 values were 189." | ( Evaluation of three antidotes on arsenic toxicity in the common earthworm (Lumbricus terrestris). Chien, PK; Furst, A; Li, W, ) | 0.13 |
| " It is concluded that maternal and developmental toxicity occur in the same dose range for this potent cytotoxicant, although differential no observed adverse effect levels can be identified depending on the endpoints used." | ( Maternal toxicity and the identification of inorganic arsenic as a developmental toxicant. Golub, MS, ) | 0.13 |
| " These results suggest that GSH plays a role in protecting the cells against the toxic effects of As3+, As5+, MAA and TMAO while it is involved in the induction of the cytotoxic effects of DMAA." | ( Glutathione plays different roles in the induction of the cytotoxic effects of inorganic and organic arsenic compounds in cultured BALB/c 3T3 cells. Kaise, T; Ochi, T; Oya-Ohta, Y, 1994) | 0.29 |
| " Cases of the use of illicit drugs laced with various toxic agents such as cyanide and strychnine have been reported." | ( Arsenic toxicity in Hawaii: a case report and review. Nakatsuka, CH; Nakawatase, TV, 1993) | 0.29 |
| " We have investigated whether these toxic effects of arsenite and the cellular arsenic content are also modulated by the intracellular GSH." | ( Glutathione as a cellular defence against arsenite toxicity in cultured Chinese hamster ovary cells. Huang, CF; Huang, H; Jan, KY; Jinn, CM; Wu, DR, 1993) | 0.29 |
| " A methylation threshold hypothesis for In-As has been proposed, stating that after exposure to In-As reaches a certain level or threshold, methylation capacity begins to decline, thus increasing the toxic effects of In-As." | ( Human studies do not support the methylation threshold hypothesis for the toxicity of inorganic arsenic. Goeden, HM; Hopenhayn-Rich, C; Smith, AH, 1993) | 0.29 |
| " Thus, toxic interactions of arsenic and cadmium appear to depend on the sequence of exposure." | ( Sequence of exposure to cadmium and arsenic determines the extent of toxic effects in male Fischer rats. Hochadel, JF; Waalkes, MP, 1997) | 0.3 |
| "Arsine, the hydride of arsenic (AsH3), is the most acutely toxic form of arsenic, causing rapid and severe hemolysis upon exposure." | ( Sequence of toxic events in arsine-induced hemolysis in vitro: implications for the mechanism of toxicity in human erythrocytes. Barber, DS; Carter, DE; Rael, LT; Winski, SL, 1997) | 0.3 |
| " These results suggest that reproductive function in hens is sensitive to adverse effects of contaminated drinking water." | ( Drinking water contaminants (arsenic, cadmium, lead, benzene, and trichloroethylene). 2. Effects on reproductive performance, egg quality, and embryo toxicity in broiler breeders. Kemppainen, BW; Lenz, SD; McElhenney, WH; Renden, JA; Vodela, JK, 1997) | 0.3 |
| " To determine if arsenic was toxic to human erythrocytes and whether this could contribute to vascular disease, human erythrocytes were incubated in vitro with sodium arsenate, As(V), or sodium arsenite, As(III), and assessed for damage." | ( Arsenate toxicity in human erythrocytes: characterization of morphologic changes and determination of the mechanism of damage. Carter, DE; Winski, SL, 1998) | 0.3 |
| " We have chosen to separate the effect of micronutrients on toxic metals into three classes: interaction between essential micronutrients and toxic metals during uptake, binding, and excretion; influence of micronutrients on the metabolism of toxic metals; and effect of micronutrients on secondary toxic effects of metals." | ( Effects of micronutrients on metal toxicity. Ayala-Fierro, F; Barber, DS; Casarez, E; Peraza, MA; Rael, LT, 1998) | 0.3 |
| " Data regarding arsenic exposure and adverse outcomes of pregnancy in humans are limited to several ecologic epidemiology studies of drinking water, airborne dusts, and smelter environs." | ( An assessment of the developmental toxicity of inorganic arsenic. DeSesso, JM; Farr, CH; Holson, JF; Jacobson, CF; Scialli, AR, ) | 0.13 |
| "Chronic, low level exposure to toxic metals is an increasing global problem." | ( Cysteine metabolism and metal toxicity. Quig, D, 1998) | 0.3 |
| " Animals were evaluated for toxic effects, including assessment of toxicant-induced alterations to the ocular and respiratory systems." | ( Acute inhalation toxicity of neutralized chemical agent identification sets (CAIS) containing agent in chloroform. Johnson, R; McVeety, B; Morgan, EW; Olajos, EJ; Phelps, RL; Renne, RA; Salem, H, ) | 0.13 |
| " The mechanism of arsenic-induced genotoxicity is very important because arsenic is a human carcinogen, but not a mutagen, and there is a need to establish recommendations for safe levels of As in the environment." | ( Arsenic toxicity is enzyme specific and its affects on ligation are not caused by the direct inhibition of DNA repair enzymes. Hu, Y; Snow, ET; Su, L, 1998) | 0.3 |
| " Although its mechanism of action is unclear, arsenic is known to exert at least some of its toxic effects through interaction with sulfhydryl groups, and the non-protein sulfhydryl glutathione (GSH) appears to play an important role in detoxication of arsenic." | ( Effect of glutathione depletion and metallothionein gene expression on arsenic-induced cytotoxicity and c-myc expression in vitro. Fulmer, BA; Hochadel, JF; Shimizu, M; Waalkes, MP, 1998) | 0.3 |
| " The statement that toxicity limits plant As uptake to safe levels was not confirmed in our study." | ( Arsenic toxicity and accumulation in radish as affected by arsenic chemical speciation. Burló, F; Carbonell-Barrachina, AA; López, E; Martínez-Sánchez, F, 1999) | 0.3 |
| " AsIII concentrations up to 1 mM were not toxic to red blood cells using these indicators." | ( In vitro tissue specificity for arsine and arsenite toxicity in the rat. Ayala-Fierro, F; Barber, DS; Carter, DE; Rael, LT, 1999) | 0.3 |
| "The common environmental pollutants arsenic, lead, and cadmium are each known to induce chronic renal disease and the molecular mechanisms of such toxic events are being clarified." | ( Mechanisms of nephrotoxicity from metal combinations: a review. Fowler, BA; Madden, EF, 2000) | 0.31 |
| " From the present study, the toxic potency of these particles was provisionally estimated to be in the following order: InAs > GaAs > As2O3, at the dosage level used in this study." | ( Comparative study of the toxic effects of gallium arsenide, indium arsenide and arsenic trioxide following intratracheal instillations to the lung of Syrian golden hamsters. Gotoh, K; Hirata, M; Inoue, N; Makita, Y; Omura, M; Tanaka, A; Yamazaki, K; Zhao, M, 2000) | 0.31 |
| "Gallium arsenide (GaAs), a chemical compound of gallium and arsenic, causes various toxic effects including pulmonary diseases in animals." | ( In vitro toxicity of gallium arsenide in alveolar macrophages evaluated by magnetometry, cytochemistry and morphology. Aizawa, Y; Karube, H; Kotani, M; Niitsuya, M; Okada, M; Okayasu, I, 1999) | 0.3 |
| " it is not more toxic to the conceptus than to the maternal organism), nor does it exhibit any propensity to cause neural tube defects, even at maternally toxic dose levels." | ( Evaluation of the prenatal developmental toxicity of orally administered arsenic trioxide in rats. Clevidence, KJ; Farr, CH; Holson, JF; Knapp, JF; Stump, DG, 2000) | 0.31 |
| " The hypothesis was that As(III) is the toxic metabolite responsible for the renal toxicity of AsH3." | ( LLC-PK1 cells as a model for renal toxicity caused by arsine exposure. Ayala-Fierro, F; Carter, DE, 2000) | 0.31 |
| "It has been proposed that arsenic exerts its toxic effects, in part, by perturbing cellular methyl metabolism." | ( Folic acid protects SWV/Fnn embryo fibroblasts against arsenic toxicity. Finnell, RH; Peterson, MH; Ruan, Y; Vorce, RL; Waes, JG; Wauson, EM, 2000) | 0.31 |
| " The toxic effects of the metals were also tested using the standard Microtox assay." | ( Direct viable count as test for toxicity assessment: the effects of four metals on a Salmonella enteritidis strain. Anzalone, C; Calimeri, S; Di Pietro, A; Lo Giudice, D; Scoglio, ME; Trimarchi, GR, ) | 0.13 |
| "Arsenic, a major water pollutant in India, produces toxic effects on female reproductive system in rodent models at the dose available in drinking water in arsenic-intoxicated zones." | ( Protection of sodium arsenite-induced ovarian toxicity by coadministration of L-ascorbate (vitamin C) in mature wistar strain rat. Chattopadhyay, S; Debnath, J; Ghosh, D; Ghosh, S, 2001) | 0.31 |
| " Also chromium was more toxic toward crustaceans than arsenic; conversely, arsenic was more toxic for the insect larvae and snail tested here." | ( Toxicity and bioaccumulation of arsenic and chromium in epigean and hypogean freshwater macroinvertebrates. Canivet, V; Chambon, P; Gibert, J, 2001) | 0.31 |
| " Therefore, the existing standard should be verified and the environmentally safe i-As concentration should be established." | ( Selected mechanisms of genotoxic effects of inorganic arsenic compounds. Gradecka, D; Palus, J; Wasowicz, W, 2001) | 0.31 |
| " Arsenic, which is found in several different chemical forms and oxidation states, causes acute and chronic adverse health effects, including cancer." | ( Arsenic toxicity and potential mechanisms of action. Hughes, MF, 2002) | 0.31 |
| " Elevated arsenic in one food source seemed to interact with selenium to reduce the toxic effects of selenium." | ( Toxicity of selenium and other elements in food organisms to razorback sucker larvae. Buhl, KJ; Bullard, FA; Hamilton, SJ; Holley, KM; McDonald, SF; Weston, LK, 2002) | 0.31 |
| " Chronic toxicity was determined by measuring the adverse effects of arsenic on brine shrimp growth, survival, and reproduction under intermittent flow-through conditions." | ( Chronic toxicity of arsenic to the Great Salt Lake brine shrimp, Artemia franciscana. Adams, WJ; Brix, KV; Cardwell, RD, 2003) | 0.32 |
| " The corresponding toxicity against normal cells (HUVEC and RAME) is much lower for all arsonoliposomes, except for the lauroyl side chain arsonoliposomes which were demonstrated to be relatively toxic towards normal cells, especially RAME." | ( Arsonoliposomes: effect of arsonolipid acyl chain length and vesicle composition on their toxicity towards cancer and normal cells in culture. Antimisiaris, SG; Gortzi, O; Ioannou, PV; Klepetsanis, P; Papadimitriou, E, 2003) | 0.32 |
| " The safe concentration, application factor and safe application rate were also calculated." | ( Acute toxicity evaluation of copper, arsenic and HCH to paddy field crab, Paratelphusa hydrodromus (Herb.). Radhakrishnan, T; Vardhanan, YS, 2002) | 0.31 |
| " Conclusion Fluoride-arsenic exposure has adverse effects on the reproductive system and the development of rats' offspring." | ( [Toxic effect of fluoride-arsenic on the reproduction and development of rats]. Ling, B; Liu, J; Wang, G; Zhang, C, 2000) | 0.31 |
| "Exposure to toxic metals has become an increasingly recognized source of illness worldwide." | ( Toxic metals and antioxidants: Part II. The role of antioxidants in arsenic and cadmium toxicity. Patrick, L, 2003) | 0.32 |
| " The results obtained indicated that arsenosugars had been metabolized to DMA, which is more toxic than arsenosugars." | ( Safety evaluation of organoarsenical species in edible Porphyra from the China Sea. Cornelis, R; Li, W; Van Hulle, M; Wei, C; Zhang, C; Zhang, X, 2003) | 0.32 |
| " The arsenite form was more toxic than arsenate." | ( Modulation of arsenic induced cytotoxicity by tea. Bhattacharya, RK; Dey, S; Roy, M; Siddiqi, M; Sinha, D, ) | 0.13 |
| " In our quest for finding out an easy, safe and affordable means to combat this problem, a homeopathic drug, Arsenicum Album-30, appears to yield promising results in mice." | ( Ameliorating effect of microdoses of a potentized homeopathic drug, Arsenicum Album, on arsenic-induced toxicity in mice. Guha, B; Khuda-Bukhsh, AR; Mallick, JC; Mallick, P, 2003) | 0.32 |
| "4% of the 28 cases of APL showed cardiac toxic reaction in different degree in the first week after As(2)O(3) intravenous infusion in general dose, mainly expressing rapid heart rate or prolonged QT interval." | ( [Study on cardiac toxicity in acute promyelocyte leukemia treatment of arsenic trioxide intravenous infusion in general dose]. Lü, CF; Meng, R; Wang, W; Yang, BF; Zhou, J, 2003) | 0.32 |
| " These results suggested that the trivalent arsenic in the mixtures of arsenicals with cysteine might account for the enhanced cytotoxicity as well as apoptosis, and that cysteine is involved in induction of the adverse effects of arsenicals in humans." | ( Effects of cysteine on the cytotoxicity of arsenic compounds. Endo, G; Endo, Y; Kuroda, K; Yoshida, K; Zhou, X, 2003) | 0.32 |
| " Within approximately 2 weeks, he developed a toxic polyneuropathy resulting in quadriparesis." | ( Arsenic toxicity from homeopathic treatment. Chakraborti, D; Chowdhury, UK; Mukherjee, SC; Rahman, MM; Saha, KC; Sengupta, MK, 2003) | 0.32 |
| " The severity of adverse health effects is related to the chemical form of arsenic, and is also time- and dose-dependent." | ( Arsenic toxicity, mutagenesis, and carcinogenesis--a health risk assessment and management approach. Centeno, JA; Patlolla, AK; Tchounwou, PB, 2004) | 0.32 |
| " Orally administered AsBe was temporally distributed to the immune organs, such as the spleen and thymus, but was not very toxic both quantitatively and qualitatively on these immune organs and immune effector cells, splenocytes, thymocytes, Peyer's patch lymphocytes and peritoneal macrophages." | ( Evaluation of in vivo acute immunotoxicity of a major organic arsenic compound arsenobetaine in seafood. Fujiwara, K; Kojima, C; Ochiai, M; Ohta, T; Sakurai, T, 2004) | 0.32 |
| " The objectives of this study were to determine if the toxic effects on primary cultured rat astroglia would be induced by different arsenicals." | ( Study on the toxic effects induced by different arsenicals in primary cultured rat astroglia. Jin, Y; Li, G; Li, X; Lu, C; Qu, L; Sun, G, 2004) | 0.32 |
| " Although the increased use of these materials has raised concerns about occupational exposure to them, there is little information regarding the adverse health effects to workers arising from exposure to these particles." | ( Toxicity of indium arsenide, gallium arsenide, and aluminium gallium arsenide. Tanaka, A, 2004) | 0.32 |
| "Cardiotoxicity is a major side effect of various antineoplastic agents, particularly the anthracyclines." | ( Prevention and management of cardiotoxicity from antineoplastic therapy. Chanan-Khan, A; Czuczman, MS; Srinivasan, S, ) | 0.13 |
| "AC) mice that had received sodium arsenite [(As(III)] in drinking water, indicating that this model is useful for studying the toxic effects of arsenic in vivo." | ( Biokinetics and subchronic toxic effects of oral arsenite, arsenate, monomethylarsonic acid, and dimethylarsinic acid in v-Ha-ras transgenic (Tg.AC) mice. Germolec, DR; Liu, J; Trouba, KJ; Waalkes, MP; Xie, Y, 2004) | 0.32 |
| " Taken together, these results suggest an innovative and safe chemotherapeutic strategy that uses natural anthraquinone derivatives as ROS generators to increase the susceptibility of tumor cells to cytotoxic therapeutic agents." | ( Anthraquinones sensitize tumor cells to arsenic cytotoxicity in vitro and in vivo via reactive oxygen species-mediated dual regulation of apoptosis. Chen, YY; Guo, QS; Hu, QS; Kang, XL; Li, H; Lu, Y; Shi, GY; Tang, XM; Wang, XJ; Yang, J; Yi, J, 2004) | 0.32 |
| "Previous studies have demonstrated that realgar nanoparticles might provide a less toxic agent for antineoplasia by suppressing angiogenesis." | ( Membrane toxicity accounts for apoptosis induced by realgar nanoparticles in promyelocytic leukemia HL-60 cells. Gan, L; Xu, HB; Yang, XL; Ye, HQ, 2005) | 0.33 |
| ", the bioavailability is low, and the food would therefore be perfectly safe to eat." | ( Arsenic speciation and toxicity in biological systems. Akter, KF; Davey, DE; Naidu, R; Owens, G, 2005) | 0.33 |
| " In previous studies we have shown that the trivalent organoarsenic compounds are more toxic than their inorganic counterparts and that the toxicity is associated with the cellular uptake of the arsenicals." | ( Forced uptake of trivalent and pentavalent methylated and inorganic arsenic and its cyto-/genotoxicity in fibroblasts and hepatoma cells. Dopp, E; Florea, AM; Hartmann, LM; Hirner, AV; Rabieh, S; Rettenmeier, AW; Shokouhi, B; von Recklinghausen, U; Yadav, S; Zimmermann, U, 2005) | 0.33 |
| " Thus, UROtsa cells are an ideal null background in which the role of iAs methylation in modulation of toxic and cancer-promoting effects of this metalloid can be examined." | ( Metabolism and toxicity of arsenic in human urothelial cells expressing rat arsenic (+3 oxidation state)-methyltransferase. Devesa, V; Drobná, Z; Harmon, AW; Stýblo, M; Thomas, DJ; Waters, SB, 2005) | 0.33 |
| " against the toxic effects of arsenic in mice." | ( Therapeutic value of Hippophae rhamnoides L. against subchronic arsenic toxicity in mice. Flora, SJ; Gupta, R, 2005) | 0.33 |
| " Its toxic effects are due to its ability to bind to sulfhydryl groups of proteins and to inhibit energy production." | ( Cytogenetic evaluation of arsenic trioxide toxicity in Sprague-Dawley rats. Patlolla, AK; Tchounwou, PB, 2005) | 0.33 |
| " We used the liver as a surrogate of target sites to assess the As toxicity to tilapia because of its higher sensitivity to As toxic effects." | ( A dose-based modeling approach for accumulation and toxicity of arsenic in tilapia Oreochromis mossambicus. Liao, CM; Tsai, JW, 2006) | 0.33 |
| " Both munitions grade and distilled Lewisite were extremely toxic with LC(50) values in the low ng/ml range, with no significant differences between them." | ( Therapeutic effects of hypothermia on Lewisite toxicity. Hancock, JR; Nelson, P; Sawyer, TW, 2006) | 0.33 |
| " By contrast, when the cytotoxic potential of DPA-GS was compared with that of DPAA, DPA-GS was about 1,000 times more toxic than DPAA, suggesting that enhancement of DPAA toxicity by SH compounds might be due to the formation of adducts in the culture medium." | ( The role of glutathione on the cytotoxic effects and cellular uptake of diphenylarsinic acid, a degradation product of chemical warfare agents. Kaise, T; Kinoshita, K; Miyazaki, K; Noguchi, A; Ochi, T; Suzuki, T, 2006) | 0.33 |
| " Based on pregnancy outcome, the developmental toxicity no observed adverse effect level (NOAEL) for orally administered MMAV were 100 and 7 mg/kg/day in the rat and rabbit, respectively, and for DMAV were 12 mg/kg/day in both species." | ( Monomethylarsonic acid and dimethylarsinic acid: developmental toxicity studies with risk assessment. Boyer, IJ; DeSesso, JM; Irvine, L, 2006) | 0.33 |
| " The proposed mathematical model links a Leslie matrix population model and a universal ontogenetic growth model embedding the population-level growth rate and stage-specific modes of toxic action." | ( Bioenergetics-based matrix population modeling enhances life-cycle toxicity assessment of tilapia Oreochromis mossambicus exposed to arsenic. Chiang, KC; Liao, CM; Tsai, JW, 2006) | 0.33 |
| " The herbicide mixture alone displayed half the toxicity of the individual herbicides, but the mixture with surfactant was twice as toxic as the individual herbicides." | ( Toxicity of a mixture of 2,4-dichlorophenoxyacetic acid and monosoduim methanearsonate to the red swamp crawfish, Procambarus clarkii. Abdelghani, AA; Green, RM, 2004) | 0.32 |
| "Arsenic is an environmental toxicant, and one of the major mechanisms by which it exerts its toxic effect is through an impairment of cellular respiration by inhibition of various mitochondrial enzymes, and the uncoupling of oxidative phosphorylation." | ( Serum acetyl cholinesterase as a biomarker of arsenic induced neurotoxicity in sprague-dawley rats. Patlolla, AK; Tchounwou, PB, 2005) | 0.33 |
| "Arsenic is naturally found in surface and ground waters and the inorganic forms of arsenic are the most toxic forms." | ( Design and development of low cost, simple, rapid and safe, modified field kits for the visual detection and determination of arsenic in drinking water samples. Anjaneyulu, Y; Cherukurii, J, 2005) | 0.33 |
| " The regimen was well tolerated, with most adverse events being mild or moderate." | ( Efficacy and safety results with the combination therapy of arsenic trioxide, dexamethasone, and ascorbic acid in multiple myeloma patients: a phase 2 trial. Abou-Jawde, RM; Andresen, S; Baz, R; Hussein, M; Karam, MA; Kelly, M; Reed, J; Walker, E, 2006) | 0.33 |
| "Exposure of cells to toxic chemicals is known to up-regulate the expression of a number of stress proteins (SPs), including metallothionein (MT) and members of the heat shock protein (HSP) family, and this response may allow the development of a fingerprint profile to identify mechanisms of toxicity in an in vitro toxicology setting." | ( Phenotypic anchoring of arsenic and cadmium toxicity in three hepatic-related cell systems reveals compound- and cell-specific selective up-regulation of stress protein expression: implications for fingerprint profiling of cytotoxicity. Atmaca, M; Fry, JR; Gottschalg, E; Kind, CN; Moore, NE; Pratt, S; Ryan, AK; Travis, LC; Waller, RC, 2006) | 0.33 |
| " Oral gavage of inorganic arsenic at maternally toxic doses caused reduced fetal body weight and increased resorptions." | ( Reproductive and developmental toxicity of arsenic in rodents: a review. Ahmed, SA; Holladay, SD; Robertson, JL; Wang, A; Wolf, DC, ) | 0.13 |
| " To our surprise DMA(III)(SG) effectively killed cells in the neighbor wells of the same multi-well dish, indicating that volatile toxic compounds generated from DMA(III)(SG) in the culture medium." | ( Cytotoxic effects of S-(dimethylarsino)-glutathione: a putative intermediate metabolite of inorganic arsenicals. Hirano, S; Kobayashi, Y, 2006) | 0.33 |
| " Specific grade 3/4 haematological (3%) or cardiac adverse events occurred infrequently." | ( Efficacy and safety of melphalan, arsenic trioxide and ascorbic acid combination therapy in patients with relapsed or refractory multiple myeloma: a prospective, multicentre, phase II, single-arm study. Berenson, JR; Bessudo, A; Boccia, R; Bozdech, M; Ferretti, D; Flam, M; Jilani, S; Louie, R; Lutzky, J; Moss, R; Patel, R; Russell, K; Siegel, D; Stadtmauer, E; Steis, R; Swift, RA; Talisman Pomeroy, J; Volk, J; Wong, SF; Yeh, HS, 2006) | 0.33 |
| "Anthracyclines are a well-known cause of cardiotoxicity, but a number of other drugs used to treat cancer can also result in cardiac and cardiovascular adverse effects." | ( Cardiac and cardiovascular toxicity of nonanthracycline anticancer drugs. Ewer, MS; Jones, RL, 2006) | 0.33 |
| "Although inorganic arsenite (As(III)) is toxic in humans, it has recently emerged as an effective chemotherapeutic agent for acute promyelocytic leukemia (APL)." | ( Toxicity of a trivalent organic arsenic compound, dimethylarsinous glutathione in a rat liver cell line (TRL 1215). Himeno, S; Hirano, S; Kobayashi, Y; Kojima, C; Sakurai, MH; Sakurai, T; Waalkes, MP, 2006) | 0.33 |
| " Because it is expensive to measure the concentrations of individual metals in large numbers of environmental samples, the general Microtox toxicity test was used to identify highly toxic soil samples." | ( Use of a general toxicity test to predict heavy metal concentrations in residential soils. Aelion, CM; Davis, HT, 2007) | 0.34 |
| " Thus, ascorbic acid blocks both the adverse effects of arsenic on male reproductive functions and the arsenic-induced testicular oxidative changes." | ( Arsenic-induced toxicity and the protective role of ascorbic acid in mouse testis. Chang, SI; Jin, B; Park, C; Park, JD; Ryu, DY; Youn, P, 2007) | 0.34 |
| " The former is regarded as most toxic to humans and plants." | ( Arsenic behaviour from groundwater and soil to crops: impacts on agriculture and food safety. Heikens, A; Meharg, AA; Panaullah, GM, 2007) | 0.34 |
| " Moreover, we examined a potential renal toxic mechanism(s) of arsenic trioxide by using a toxicity-related gene and investigated potential treatments to reduce the renal toxicity of arsenic trioxide." | ( An approach to elucidate potential mechanism of renal toxicity of arsenic trioxide. Fujimura, A; Oshima, Y; Sasaki, A, 2007) | 0.34 |
| " Toxicity identification evaluation (TIE) methods provide tools for identifying the toxic chemicals causing sediment toxicity." | ( Marine sediment toxicity identification evaluation methods for the anionic metals arsenic and chromium. Burgess, RM; Cantwell, MG; Ho, KT; Pelletier, MC; Perron, MM; Ryba, SA; Serbst, JR, 2007) | 0.34 |
| "MMAIII , one of the active intermediate in inorganic arsenic methylation, is highly toxic in BAEC." | ( [Cytotoxicity study of vascular endothelial cells by different kinds of arsenicals]. Li, B; Lu, CW; Sun, GF, 2006) | 0.33 |
| " The solutions are obtained from soil:water extracts (1:1), having neutral pH and high concentrations of As, Pb, Zn, Mn, Co and Ni, with values exceeding the toxic level for soil solution [Bohn HL, McNeal BL, O'Connor GA." | ( Determination of phytotoxicity of soluble elements in soils, based on a bioassay with lettuce (Lactuca sativa L.). García, JF; Peinado, FM; Valerio, ME, 2007) | 0.34 |
| " Organic arsenic was generally found to be less toxic to these biological models than inorganic arsenic." | ( Adverse effects of organic arsenical compounds towards Vibrio fischeri bacteria. Bollinger, JC; Fulladosa, E; Murat, JC; Villaescusa, I, 2007) | 0.34 |
| "Arsenic is a widespread environmental toxic agent that has been shown to cause diverse tissue and cell damage and at the same time to be an effective anti-cancer therapeutic agent." | ( A critical role for IkappaB kinase beta in metallothionein-1 expression and protection against arsenic toxicity. Fan, Y; Peng, L; Peng, Z; Shertzer, HG; Xia, Y; Zandi, E, 2007) | 0.34 |
| " As may play a role in the disruption of neuroskeletal integrity, but the mechanisms by which it exerts a toxic effect on the peripheral and central nervous system are still unclear." | ( Arsenic metabolites affect expression of the neurofilament and tau genes: an in-vitro study into the mechanism of arsenic neurotoxicity. de Wolff, FA; Romijn, F; Vahidnia, A; van der Straaten, RJ; van der Voet, GB; van Pelt, J, 2007) | 0.34 |
| " These results suggest that although DMMTA (V) is a pentavalent arsenical, it is taken up efficiently by cells and causes various levels of toxicity, in a manner different from that of nonthiolated pentavalent arsenicals, demonstrating that DMMTA (V) is one of the most toxic arsenic metabolites." | ( Toxicity of dimethylmonothioarsinic acid toward human epidermoid carcinoma A431 cells. Ibata, K; Naranmandura, H; Suzuki, KT, 2007) | 0.34 |
| " Toxicity, based on median lethal concentrations (LC50 values), clustered the arsenicals into three groups and followed the order (most toxic to least toxic) of monomethylarsonous acid (MMA(III)), 120 microg/L > inorganic arsenic, 2,500 to 3,900 microg/L > pentavalent methylated arsenicals and phenylarsonic compounds, 13,800 to 15,700 microg/L." | ( Acute toxicity of arsenic to Daphnia pulex: influence of organic functional groups and oxidation state. Folt, CL; Glaholt, SP; Greenberg, NS; Shaw, JR; Sierra-Alvarez, R, 2007) | 0.34 |
| " The current work lays the groundwork for using Nrf2 activators for therapeutic and dietary interventions against adverse effects of arsenic." | ( Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity. Chen, W; Eblin, KE; Gandolfi, JA; Sun, Z; Wang, XJ; Zhang, DD, 2007) | 0.34 |
| " The toxic metals cadmium (Cd), arsenic (As), and lead (Pb) can target the vascular system in a variety of ways, ranging from hemorrhagic injury to subtle pathogenic remodeling and metabolic changes." | ( The vascular system as a target of metal toxicity. Atchison, WD; Barchowsky, A; Edwards, JR; Nebert, DW; Prozialeck, WC; Woods, JM, 2008) | 0.35 |
| " Here we examined the effects of MSMA in the laboratory using the zebra finch (Taeniopygia guttata), with the objective to examine tissue distribution and sublethal toxic effects in a model avian species." | ( Dose-dependent uptake, elimination, and toxicity of monosodium methanearsonate in adult zebra finches (Taeniopygia guttata). Albert, CA; Cullen, WR; Elliott, JE; Lai, VW; Morrissey, CA; Williams, TD, 2008) | 0.35 |
| "To evaluate the food safety of fish from production systems in Hanoi feed with domestic and industrial wastewater with respect to the potentially toxic elements such as arsenic (As), cadmium (Cd) and lead (Pb)." | ( Food safety aspects of toxic element accumulation in fish from wastewater-fed ponds in Hanoi, Vietnam. Dalsgaard, A; Holm, PE; Le, TH; Marcussen, H, 2007) | 0.34 |
| "Exposure to arsenic is known to cause adverse effects in aquatic biota and wildlife and is of major concern to human health." | ( The influence of exposure history on arsenic accumulation and toxicity in the killifish, Fundulus heteroclitus. Gabor, K; Hamilton, JW; Jackson, B; Shaw, JR; Stanton, BA; Stanton, S, 2007) | 0.34 |
| " Most of the adverse effects of As, are caused by inactivated enzymes in the cellular energy pathway, whereby As reacts with the thiol groups of proteins and enzymes and inhibits their catalytic activity." | ( Arsenic neurotoxicity--a review. de Wolff, FA; Vahidnia, A; van der Voet, GB, 2007) | 0.34 |
| " The health consequences of chronic arsenic exposure include increased risk for various forms of cancer and numerous noncancer effects, including diabetes, skin diseases, chronic cough, and toxic effects on liver, kidney, cardiovascular system, and peripheral and central nervous systems." | ( Interactions between arsenic-induced toxicity and nutrition in early life. Vahter, ME, 2007) | 0.34 |
| "This work probabilistically explored a safe utilization ratio (UR) of groundwater in fish ponds located in blackfoot disease hyperendemic areas in terms of the regulation of arsenic (As) concentrations." | ( Probabilistic assessment of safe groundwater utilization in farmed fish ponds of blackfoot disease hyperendemic areas in terms of the regulation of arsenic concentrations. Jang, CS, 2008) | 0.35 |
| " We investigated the toxic mechanisms of As(2)O(3) in H9c2 cardiomyocytes." | ( Arsenic trioxide-induced apoptosis in H9c2 cardiomyocytes: implications in cardiotoxicity. Chen, H; Feng, T; Lu, Y; Shan, H; Yang, B; Zhang, Y; Zhao, X, 2008) | 0.35 |
| " japonicus could also be used in reproduction and life cycle tests and it provides an opportunity for testing the chronic and subchronic toxic effects of marine pollutants." | ( Two-generation toxicity study on the copepod model species Tigriopus japonicus. Ahn, IY; Dahms, HU; Hwang, DS; Lee, JS; Lee, KW; Park, HG; Raisuddin, S, 2008) | 0.35 |
| " There is no effective remedial action of chronic arsenicosis, however, a well-nourished diet can modulate the onset of adverse health effects and the delayed effect of arsenic in drinking water." | ( Genotoxic effects of arsenic: prevention by functional food-jaggery. Kumar, D; Raisuddin, S; Sahu, AP; Singh, N, 2008) | 0.35 |
| " The results showed that iAs(III) was toxic on male and female colony forming units to about the same extent both in human and in mouse." | ( Toxicity of inorganic arsenic and its metabolites on haematopoietic progenitors "in vitro": comparison between species and sexes. Bowe, G; Brustio, R; Collotta, A; Croera, C; Ferrario, D; Gribaldo, L; Vahter, M, 2008) | 0.35 |
| " Any large-scale treatment strategy to remove arsenic from groundwater must take into consideration safe containment of the arsenic removed with no adverse ecological impact." | ( Arsenic removal from groundwater and its safe containment in a rural environment: validation of a sustainable approach. Blaney, LM; Ghosh, D; Gupta, A; Sarkar, S; Sengupta, AK, 2008) | 0.35 |
| " Environmental Protection Agency (EPA) and Agency for Toxic Substances and Disease Registry (ATSDR) models of noncancer mixture toxicity." | ( Combining occurrence and toxicity information to identify priorities for drinking-water mixture research. Ryker, SJ; Small, MJ, 2008) | 0.35 |
| " The misclassification of methylmercury and the potential environmental exposure to developmental toxic heavy metals promoted our investigation of whether the EST applicability domain covers cadmium and arsenic compounds." | ( Embryotoxicity hazard assessment of cadmium and arsenic compounds using embryonic stem cells. Bremer, S; Hareng, L; Stummann, TC, 2008) | 0.35 |
| "The sludge produced in sewage treatment plants can contain toxic substances." | ( Evaluation of the genotoxicity of treated urban sludge in the Tradescantia micronucleus assay. Matta, ME; Mielli, AC; Nersesyan, A; Saldiva, PH; Umbuzeiro, GA, 2009) | 0.35 |
| " The ubiquitous toxic metalloid arsenic, as well as mercury and nickel, are shown here to efficiently inhibit the rapamycin-sensitive TORC1 (TOR complex 1) protein kinase." | ( Arsenic toxicity to Saccharomyces cerevisiae is a consequence of inhibition of the TORC1 kinase combined with a chronic stress response. Ammerer, G; Hosiner, D; Lempiäinen, H; Loewith, R; Reiter, W; Schüller, C; Schweyen, R; Shore, D; Urban, J, 2009) | 0.35 |
| " As(III) was found to be more toxic than As(V) to Daphnia survival." | ( Toxicity of tri- and penta-valent arsenic, alone and in combination, to the cladoceran Daphnia carinata: the influence of microbial transformation in natural waters. He, W; Megharaj, M; Naidu, R, 2009) | 0.35 |
| " Arsenic is known to be one of the most toxic metalloids naturally occurring in the environment giving rise to severe toxic manifestations including cancer." | ( As2O3 toxicity in rat hepatocytes: manifestation of caspase-mediated apoptosis. Agarwal, S; Bhattacharya, S; Ray, A; Roy, S, 2008) | 0.35 |
| " In cells pretreated with V-PROLI/NO (200 microM, 24 h) then exposed to arsenic for an additional 24 h, arsenic was much less toxic (LC(50) = 151." | ( V-PROLI/NO, a nitric oxide donor prodrug, protects liver cells from arsenic-induced toxicity. Dill, AL; Keefer, LK; Liu, J; Qu, W; Saavedra, JE; Waalkes, MP, 2009) | 0.35 |
| " The exact molecular mechanism of cardiovascular adverse effect due to ATO exposure has not been fully elucidated except for alteration on ion channels." | ( Characterization of cytotoxicity induced by arsenic trioxide (a potent anti-APL drug) in rat cardiac myocytes. Cherian, OL; Raghu, KG, 2009) | 0.35 |
| " Accordingly, a direct toxicity assessment (DTA) based on chronoamperometry was proposed to detect the effect of toxic chemicals on microorganisms." | ( Direct toxicity assessment of toxic chemicals with electrochemical method. Dong, S; Liu, C; Sun, T; Xu, X, 2009) | 0.35 |
| " The present study aimed at comparing the toxic effect of DMMTA(V) with that of inorganic arsenite (iAs(III)) on cell viability, uptake efficiency and production of reactive oxygen species (ROS) toward human bladder cancer EJ-1 cells." | ( Evidence for toxicity differences between inorganic arsenite and thioarsenicals in human bladder cancer cells. Iwata, K; Le, XC; Lee, J; Naranmandura, H; Ogra, Y; Suzuki, KT; Weinfeld, M, 2009) | 0.35 |
| " Toxic responses to mercury were more evident than for arsenic, especially in shoot tissues." | ( Arsenic- and mercury-induced phytotoxicity in the Mediterranean shrubs Pistacia lentiscus and Tamarix gallica grown in hydroponic culture. Carpena-Ruiz, RO; Esteban, E; Moreno-Jiménez, E; Peñalosa, JM, 2009) | 0.35 |
| " Environmental contaminants, such as trace elements, may be present in all foods and, as a result, international standards have been established for a number of toxic trace elements, such as cadmium, lead, mercury and arsenic, in raw food commodities and food products." | ( Trace elements in Canadian field peas: a grain safety assurance perspective. Garrett, RG; Gawalko, E; Richter, A; Wang, N; Warkentin, T, 2009) | 0.35 |
| " Silencing of MYST1 reduced acetylation of H4K16 and induced sensitivity to As(III) and to its more toxic metabolite monomethylarsonous acid (MMA(III)) at doses relevant to high environmental human exposures." | ( Acetylated H4K16 by MYST1 protects UROtsa cells from arsenic toxicity and is decreased following chronic arsenic exposure. Aleshin, M; Burlingame, A; Chu, F; Jo, WJ; Ren, X; Smith, MT; Vulpe, CD; Wintz, H; Zhang, L, 2009) | 0.35 |
| "RBS has potent antitumor effect, LD50 value of RBS is lower than that of traditional medicine." | ( [The inhibitory effects of Realgar bioleaching solution on S180 ascites-tumor and its toxicity]. Bai, L; Li, HY; Wang, X; Xie, QJ; Zhang, X, 2009) | 0.35 |
| "To compare the efficacy and adverse effects between arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) in patients with acute promyelocytic leukemia (APL)." | ( [Comparison of efficacy and adverse effects between arsenic trioxide and all-trans retinoic acid in patients with acute promyelocytic leukemia]. Duan, MH; Han, B; Jiao, L; Shen, T; Wang, SJ; Xu, Y; Zhang, W; Zhao, YQ; Zhou, DB; Zhu, TN; Zhuang, JL; Zou, N, 2009) | 0.35 |
| " Compared with ATRA, ATO induction therapy has shorter time to achieve CR and less adverse effects, and therefore may be the first-line therapy for APL." | ( [Comparison of efficacy and adverse effects between arsenic trioxide and all-trans retinoic acid in patients with acute promyelocytic leukemia]. Duan, MH; Han, B; Jiao, L; Shen, T; Wang, SJ; Xu, Y; Zhang, W; Zhao, YQ; Zhou, DB; Zhu, TN; Zhuang, JL; Zou, N, 2009) | 0.35 |
| "Display devices such as cathode-ray tube (CRT) televisions and computer monitors are known to contain toxic substances and have consequently been banned from disposal in landfills in the State of California and elsewhere." | ( Human health and ecological toxicity potentials due to heavy metal content in waste electronic devices with flat panel displays. Lim, SR; Schoenung, JM, 2010) | 0.36 |
| " Results revealed that curcumin efficiently ameliorates the toxic effect of As and F by reducing the frequency of structural aberrations (>60%), hypoploidy (>50%) and primary DNA damage." | ( Curcumin supplementation protects from genotoxic effects of arsenic and fluoride. Rao, MV; Tiwari, H, 2010) | 0.36 |
| " In contrast, "targeting As-safe aquifers" was socially accepted in Bangladesh, where sediment color could be used to identify As-safe aquifer zones and to install safe wells." | ( Targeting arsenic-safe aquifers for drinking water supplies. Bhattacharya, P; Bundschuh, J; Litter, MI, 2010) | 0.36 |
| " Arsenic is a documented toxic element in drinking water." | ( Using iron precipitants to remove arsenic from water: is it safe? Huang, PC; Liu, MY; Mohan Chandrasekaran, VR; Muthaiyan, I, 2010) | 0.36 |
| " Besides daily monitoring for clinical signs of adverse health effects, clinical biochemistry, B-cell-mediated and innate immune responses, plus gross, and histopathology were examined." | ( Pathological, immunological and biochemical markers of subchronic arsenic toxicity in rats. Nain, S; Smits, JE, 2012) | 0.38 |
| " Alcohol is clearly a toxic substance when consumed in excess." | ( Potential molecular mechanisms for combined toxicity of arsenic and alcohol. Bao, L; Shi, H, 2010) | 0.36 |
| " This metalloid acts as a promoter of carcinogenesis, exerting toxic effects on the immune system." | ( Immunological profile of arsenic toxicity: a hint towards arsenic-induced carcinogenesis. Acharya, S; Begum, Z; Chatterjee, S; Chaudhuri, S; Dasgupta, S; Flora, SJ; Kumar, P, 2010) | 0.36 |
| " In this book chapter we give a summary of the current state of knowledge on the toxicities and toxicological mechanisms of organoarsenic species in order to evaluate the role and significance of these regarding their adverse effects on human health." | ( Organoarsenicals. Uptake, metabolism, and toxicity. Diaz-Bone, RA; Dopp, E; Kligerman, AD, 2010) | 0.36 |
| "Arsenic trioxide (ATO) treatment is a useful therapy against human acute promyelocytic leukemia (APL), however, it concomitantly brings potential adverse consequences including serious side effect, human carcinogenicity and possible development of resistance." | ( Cytotoxicity of arsenic trioxide is enhanced by (-)-epigallocatechin-3-gallate via suppression of ferritin in cancer cells. Cheng, IC; Lee, TC; Shue, JJ; Wang, TC, 2011) | 0.37 |
| "Arsenic (As) is a widespread pollutant in the world and its toxicity is related to its chemical form, with inorganic forms being considered more toxic than the organic form, and huge differences in effects and processes of metabolism." | ( Arsenic toxicity in mammals and aquatic animals: a comparative biochemical approach. Bogo, MR; Monserrat, JM; Ventura-Lima, J, 2011) | 0.37 |
| " While many toxicity investigations have been conducted, there is little information about the synergistic effect of ENMs and other toxic compounds in the environment." | ( Synergistic toxic effect of nano-TiO and As(V) on Ceriodaphnia dubia. Hu, J; Irons, DR; Wang, D; Wang, J, 2011) | 0.37 |
| "The clinical use of arsenic trioxide (ATO) is often limited because of its adverse effects." | ( Protective effect of α-lipoic acid against arsenic trioxide-induced acute cardiac toxicity in rats. Ando, H; Fujimura, A; Hosohata, K; Koshimizu, TA; Kumazaki, M; Oshima, Y; Sasaki, A; Ushijima, K, 2011) | 0.37 |
| "Arsenic (As) is a toxic metalloid element that is present in air, water and soil." | ( Arsenic: toxicity, oxidative stress and human disease. Baros, S; Feszterova, M; Hudecova, D; Jenisova, Z; Jomova, K; Liska, J; Rhodes, CJ; Valko, M, 2011) | 0.37 |
| "The effects of iron (Fe) and spent mushroom substrate (SMS) arsenic (As) phytotoxicity towards lettuce in artificial soils were investigated to separate the adverse soil parameters relating to As toxicity using a response surface methodology." | ( Using response surface methodology to assess the effects of iron and spent mushroom substrate on arsenic phytotoxicity in lettuce (Lactuca sativa L.). Jo, HJ; Kim, JG; Koo, N; Lee, SH, 2011) | 0.37 |
| " The toxic effects associated with STPs have been associated with trace level contaminants present in these products." | ( Assessment of potential toxicity of a smokeless tobacco product (naswar) available on the Pakistani market. Gul, F; Humayun, M; Khan, H; Khan, SA; Khuda, F; Muhammad, N; Saeed, M, 2012) | 0.38 |
| "A total of 30 Pakistani brands of naswar were tested for a variety of toxic constituents and carcinogens such as cadmium, arsenic, lead and other carcinogenic metals, nitrite and nitrate, and nicotine and pH." | ( Assessment of potential toxicity of a smokeless tobacco product (naswar) available on the Pakistani market. Gul, F; Humayun, M; Khan, H; Khan, SA; Khuda, F; Muhammad, N; Saeed, M, 2012) | 0.38 |
| " There were no statistically significant differences between two treatments in terms of early death and main adverse events." | ( The efficacy and safety of arsenic trioxide with or without all-trans retinoic acid for the treatment of acute promyelocytic leukemia: a meta-analysis. Chen, HZ; Chen, XY; Qi, H; Rong, ZX; Wang, BS; Wang, H, 2011) | 0.37 |
| " Thioarsenicals are commonly found in human and animal urine and are also considered to be highly toxic arsenic metabolites." | ( Comparative toxicity of arsenic metabolites in human bladder cancer EJ-1 cells. Carew, MW; Le, XC; Lee, J; Leslie, EM; Naranmandura, H; Weinfeld, M; Xu, S, 2011) | 0.37 |
| " The toxic effect of arsenic was also indicated by significantly decreased activities of enzymatic antioxidants like superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase and glucose-6-phosphate dehydrogenase along with non-enzymatic antioxidant like reduced glutathione." | ( Protective role of sinapic acid against arsenic: induced toxicity in rats. Mohamed Jalaludeen, A; Pari, L, 2011) | 0.37 |
| " We believe that a biosensor of the proposed design can be integrated into future water safety and security networks, as part of an early warning system against accidental or intentional water pollution by toxic chemicals." | ( Online monitoring of water toxicity by use of bioluminescent reporter bacterial biochips. Almog, R; Belkin, S; Elad, T; Levkov, K; Melamed, S; Shacham-Diamand, Y; Yagur-Kroll, S, 2011) | 0.37 |
| " Adverse health effects following selenium overexposure, although very rare, have been found in animals and people." | ( Selenium interactions and toxicity: a review. Selenium interactions and toxicity. Zaporowska, H; Zwolak, I, 2012) | 0.38 |
| " Toxic changes related to the treatment of realgar and no-observed adverse effect level (NOAEL) was evaluated." | ( [Toxicity study of realgar]. Li, C; Li, H; Liang, A; Nilsen, OG; Wang, J; Xie, Q; Xue, B; Yang, B, 2011) | 0.37 |
| "696 mg x g(-1) soluble asenic, LD50 of Realgar with oral administration was 20." | ( [Toxicity study of realgar]. Li, C; Li, H; Liang, A; Nilsen, OG; Wang, J; Xie, Q; Xue, B; Yang, B, 2011) | 0.37 |
| " Toxic minerals such as arsenic and lead are the two most important components of BDSJS." | ( [Attenuation effects of compatible medicines on arsenical and lead toxicity of badu shengji san]. Gao, J; He, R; Li, J; Lu, Y; Peng, B, 2011) | 0.37 |
| " Our results suggest that a metal sensitive compartment comprising the cellular debris, enzymes and organelles fractions may be more representative of the toxic effects observed." | ( Arsenic toxicity in a sediment-dwelling polychaete: detoxification and arsenic metabolism. Casado-Martinez, MC; Duncan, E; Maher, WA; Rainbow, PS; Smith, BD, 2012) | 0.38 |
| " Both arsenic and mercury are well-known for toxic effects and the safety of realgar-and cinnabar-containing traditional Chinese medicines is of concern." | ( [Safety evaluation of realgar-and cinnabar-containing traditional Chinese medicine]. Liu, J; Lu, Y; Shi, J, 2011) | 0.37 |
| " The observed patterns of associations suggest that MMA% and DMA% have distinct genetic determinants and support the hypothesis that DMA is the less toxic of these two methylated arsenic species." | ( Genome-wide association study identifies chromosome 10q24.32 variants associated with arsenic metabolism and toxicity phenotypes in Bangladesh. Ahmed, A; Ahsan, H; Alam, S; Argos, M; Baron, JA; Gamble, MV; Graziano, JH; Hore, SK; Islam, T; Jasmine, F; Kibriya, MG; Parvez, F; Paul-Brutus, R; Pierce, BL; Quasem, I; Rahaman, R; Rahman, M; Rakibuz-Zaman, M; Roy, S; Slavkovich, V; Tong, L; Yunus, M, 2012) | 0.38 |
| " Although the exact role of toxic arsenic compounds in the treatment of oxidative injury remains unclear, concomitant HO-1 induction may be a key mechanism to antagonize the cytotoxicity of arsenic compounds in human cells." | ( Concomitant induction of heme oxygenase-1 attenuates the cytotoxicity of arsenic species from lumbricus extract in human liver HepG2 cells. Chen, B; Le, XC; Qi, H; Rong, J, 2012) | 0.38 |
| " That is, this paradigm would be protective of any mechanism that resulted in adverse effects typically observed in guideline studies, because product safety assessment is based upon observed apical effects to drive an overall NOAEL that is the basis to set reference doses for a risk assessment." | ( Is the current product safety assessment paradigm protective for epigenetic mechanisms? Alyea, RA; Gollapudi, BB; LeBaron, MJ; Moore, NP; Rasoulpour, RJ, ) | 0.13 |
| "These adverse apical effects are the culmination of all molecular events, regardless of mechanism and may include alterations in the epigenome secondary to the actions of those mechanism(s)." | ( Is the current product safety assessment paradigm protective for epigenetic mechanisms? Alyea, RA; Gollapudi, BB; LeBaron, MJ; Moore, NP; Rasoulpour, RJ, ) | 0.13 |
| " Co-administration of ECNPs provided pronounced beneficial effects on the adverse changes in oxidative stress parameters induced by arsenic." | ( Curcumin encapsulated in chitosan nanoparticles: a novel strategy for the treatment of arsenic toxicity. Flora, SJ; Lomash, V; Samim, M; Yadav, A, 2012) | 0.38 |
| " In contrast to silicon, InAs forms an unstable oxide layer under ambient conditions, which can corrode over time and leach toxic indium and arsenic components." | ( Wet-chemical passivation of InAs: toward surfaces with high stability and low toxicity. Ivanisevic, A; Jewett, SA, 2012) | 0.38 |
| "9%) achieved a hematologic complete remission, and the most common adverse event during remission induction was leukocytosis (63." | ( Long-term efficacy and safety of arsenic trioxide for first-line treatment of elderly patients with newly diagnosed acute promyelocytic leukemia. Fan, S; Han, L; Han, X; Hu, L; Li, J; Li, L; Li, X; Li, Y; Lv, C; Su, Y; Wang, S; Zhang, X; Zhang, Y; Zhang, Z; Zhao, H; Zhao, Y; Zhou, J, 2013) | 0.39 |
| "The results indicate that the single-agent ATO regimen is safe and effective with long-term durable remission, and could be used as first-line treatment for elderly patients with de novo APL." | ( Long-term efficacy and safety of arsenic trioxide for first-line treatment of elderly patients with newly diagnosed acute promyelocytic leukemia. Fan, S; Han, L; Han, X; Hu, L; Li, J; Li, L; Li, X; Li, Y; Lv, C; Su, Y; Wang, S; Zhang, X; Zhang, Y; Zhang, Z; Zhao, H; Zhao, Y; Zhou, J, 2013) | 0.39 |
| " However, they may also serve as carriers of toxic contaminants and negatively impact the environment and human health." | ( Quantifying the effect of nanoparticles on As(V) ecotoxicity exemplified by nano-Fe2 O3 (magnetic) and nano-Al2 O3. Forthaus, BE; Hu, J; Wang, D; Wang, J, 2012) | 0.38 |
| " The authors conclude that As(2) O(3) -induced DNA damage and apoptosis are mediated by oxidative stress and selenium and that, although toxic at higher concentrations, selenium provides significant protection against As(2) O(3) effects in PLHC-1 cells." | ( Protective and antioxidant role of selenium on arsenic trioxide-induced oxidative stress and genotoxicity in the fish hepatoma cell line PLHC-1. Murray, E; Selvaraj, V; Yeager-Armstead, M, 2012) | 0.38 |
| " Arsenic methylation has been considered to be a detoxification process of inorganic arsenicals, although recent studies have indicated that trivalent methylated arsenicals, the intermediate products of arsenic methylation, are more toxic than inorganic arsenicals." | ( Role of arsenic (+3 oxidation state) methyltransferase in arsenic metabolism and toxicity. Himeno, S; Sumi, D, 2012) | 0.38 |
| "While water and sanitation are now recognized as a human right by the United Nations, monitoring inequality in safe water access poses challenges." | ( Water safety and inequality in access to drinking-water between rich and poor households. Bain, R; Bartram, J; Gundry, S; Pedley, S; Wright, J; Yang, H, 2013) | 0.39 |
| " In Bangladesh, eight major safe water options provide an alternative to contaminated shallow tubewells: piped water supply, deep tubewells, pond sand filters, community arsenic-removal, household arsenic removal, dug wells, well-sharing, and rainwater harvesting." | ( Acceptance and use of eight arsenic-safe drinking water options in Bangladesh. Hossain, MM; Inauen, J; Johnston, RB; Mosler, HJ, 2013) | 0.39 |
| " To understand the adverse effect of this toxic metabolite on biological system (cellular targets), and to unravel the underlying molecular basis (at the level of transcript, proteome, or metabolite), a holistic, systems biology approach was taken." | ( Systems biology approaches to evaluate arsenic toxicity and carcinogenicity: an overview. Bhattacharjee, P; Chatterjee, D; Giri, AK; Singh, KK, 2013) | 0.39 |
| " The gastrointestinal mucosa is exposed to these forms of arsenic, but it is not known what toxic effect these species may have on it." | ( Differential toxicity and gene expression in Caco-2 cells exposed to arsenic species. Calatayud, M; Devesa, V; Vélez, D, 2013) | 0.39 |
| "The present study was designed to investigate the toxic mechanism of arsenic in cardiac tissue at its clinically relevant concentrations." | ( Myocardial toxicity of acute promyelocytic leukaemia drug-arsenic trioxide. Abhilash, M; Abhilash, S; Manju, A; Mathews, VV; Nair, RH; Paul, MV, 2013) | 0.39 |
| " The undissociated H3AsO3 was more toxic than its monoanionic H2AsO3(-) through comparison of algal cell numbers, chlorophyll-a contents, and algal ultrastructural changes observed with transmission electron microscopy." | ( Biosorption and toxicity responses to arsenite (As[III]) in Scenedesmus quadricauda. Ding, T; Zhang, C; Zhang, J, 2013) | 0.39 |
| " The least toxic condition was 25 °C-S 17." | ( Acute toxicity of arsenic under different temperatures and salinity conditions on the white shrimp Litopenaeus vannamei. Fernández-Bringas, L; Núñez-Nogueira, G; Valentino-Álvarez, JA, 2013) | 0.39 |
| " In vitro study based on HepG2 cell line found that Fe increased the As toxicity on cell viability and DNA damage, indicating the synergetic toxic effects." | ( Impact of iron precipitant on toxicity of arsenic in water: a combined in vivo and in vitro study. Cui, Y; Guo, X; Liu, S; Wu, B; Zhang, X; Zhang, Y, 2013) | 0.39 |
| " Among the three elements present in wood leachates, As played the primary role in the observed toxic effects, which were exerted through multiple pathways, including the generation of oxidative stress." | ( Arsenic toxicity in the human nerve cell line SK-N-SH in the presence of chromium and copper. Cai, Y; Fieber, LA; Greer, JB; Hu, L; Solo-Gabriele, H, 2013) | 0.39 |
| " Cell cytotoxicity and reactive oxygen species (ROS) changes were performed in combinations of As(III) and selenomethionine (SeMet) toxic mixes on, HEK293, human kidney cells." | ( Selenium mediated arsenic toxicity modifies cytotoxicity, reactive oxygen species and phosphorylated proteins. Caruso, JA; Chitta, KR; Landero Figueroa, JA; Merino, EJ, 2013) | 0.39 |
| " In the prescription, significant level of realgar (As2S2) as a potentially toxic element is contained." | ( (1)H NMR-based metabonomics study on the toxicity alleviation effect of other traditional Chinese medicines in Niuhuang Jiedu tablet to realgar (As2S2). Chen, G; Li, W; Pei, Y; Wang, H; Xiang, R; Xu, W, 2013) | 0.39 |
| "Our results indicated that it was more secure and much less toxic for counterbalanced realgar (As2S2) in NJT." | ( (1)H NMR-based metabonomics study on the toxicity alleviation effect of other traditional Chinese medicines in Niuhuang Jiedu tablet to realgar (As2S2). Chen, G; Li, W; Pei, Y; Wang, H; Xiang, R; Xu, W, 2013) | 0.39 |
| " Chronic exposure to As is associated with adverse effects on human health such as cancers, cardiovascular diseases, neurological diseases and the rate of morbidity and mortality in populations exposed is alarming." | ( Arsenic-induced genotoxicity and genetic susceptibility to arsenic-related pathologies. Andreassi, MG; Bianchi, F; Cori, L; Faita, F, 2013) | 0.39 |
| " The objectives of this research were to investigate the toxic effect of Fe₃O₄ NPs in combination with As(V)." | ( Combined toxicity of ferroferric oxide nanoparticles and arsenic to the ciliated protozoa Tetrahymena pyriformis. Xu, B; Yu, CP; Zhang, HW; Zou, XY, 2013) | 0.39 |
| "001), the instrumental attitude towards the safe water option (B = 0." | ( Predicting water consumption habits for seven arsenic-safe water options in Bangladesh. Inauen, J; Mosler, HJ; Tobias, R, 2013) | 0.39 |
| " However, the toxic effects of As on photosynthesis were significantly ameliorated by SNP." | ( Nitric oxide alleviates arsenic-induced toxic effects in ridged Luffa seedlings. Prasad, SM; Singh, VP; Srivastava, PK, 2013) | 0.39 |
| " The median concentrations of the most toxic compounds, As, Cd, Pb, and Hg, were relatively low (0." | ( Potential adverse effects of inorganic pollutants on clinical parameters of loggerhead sea turtles (Caretta caretta): results from a nesting colony from Cape Verde, West Africa. Boada, LD; Camacho, M; Formigaro, C; López, P; Luzardo, OP; Orós, J; Silvi, M; Zaccaroni, A; Zumbado, M, 2013) | 0.39 |
| " In this study, we investigated the toxic effects of sodium arsenite (NaAsO2) on primary cultured rat cerebellar granule neurons (CGNs) and detected neuroglobin (Ngb) expression in rat CGNs exposed to NaAsO2." | ( Neuroglobin involvement in the course of arsenic toxicity in rat cerebellar granule neurons. Gao, Y; Liu, X; Sun, D; Wang, J; Yao, H; Zhou, L, 2013) | 0.39 |
| " However, it may also accumulate toxic elements such as metal(oids)." | ( Cytotoxic and genotoxic effects of metal(oid)s bioactivated in rocket leaves (Eruca vesicaria subsp. sativa Miller). Alonso-Moraga, A; Amaro-López, MÁ; Anter, J; De Haro Bailón, A; Del Río-Celestino, M; Font, R; Moreno-Rojas, R; Muñoz-Serrano, A; Obregón-Cano, S; Villatoro-Pulido, M, 2013) | 0.39 |
| " Due to the ability of Se to interact with As and to possibly block its toxic effects, we investigated the impact of dietary Se-methionine (Se-Met) supplementation on the toxicity of As exposure in vivo in a mouse model." | ( Effect of selenomethionine supplementation in food on the excretion and toxicity of arsenic exposure in female mice. Del Razo, LM; García-Montalvo, EA; Rodríguez-Sosa, M; Vega, L, 2013) | 0.39 |
| "The ubiquitous presence of arsenic (a toxic metalloid) in our environment, particularly in our drinking water, is a serious health hazard of global concern." | ( Induction of sperm impairments in mice as a sensitive biomarker of arsenic toxicity. Kesari, VP; Khan, PK; Kumar, A, 2014) | 0.4 |
| " Moreover, the seawater incursion and organic pollution in the study area may be the key factors resulting in the incubation of toxic substances." | ( Biological toxicity of groundwater in a seashore area: causal analysis and its spatial pollutant pattern. Chen, HW; Chen, WY; Chuang, YH; Huang, WJ; Lin, YH, 2014) | 0.4 |
| "To delineate arsenic (As) safe aquifer(s) within shallow depth, the present study has investigated the shallow hydrostratigraphic framework over an area of 100 km(2) at Chakdaha Block of Nadia District, West Bengal." | ( Shallow hydrostratigraphy in an arsenic affected region of Bengal Basin: implication for targeting safe aquifers for drinking water supply. Alexanderson, H; Bhattacharya, P; Biswas, A; Chatterjee, D; Jacks, G; Kundu, AK; Mukherjee, A; Nath, B, 2014) | 0.4 |
| "Arsenic (As) is a toxic metalloid found ubiquitously in the environment and widely considered an acute poison and carcinogen." | ( Transcriptome profiling of genes and pathways associated with arsenic toxicity and tolerance in Arabidopsis. Chen, PY; Fu, SF; Huang, HJ; Huang, LY; Huang, TL; Lin, CY; Nguyen, QT; Zeng, GR, 2014) | 0.4 |
| " Testing acute toxicity of mono- and trithioarsenate individually, both thioarsenates were found to be more toxic than their structural analogue arsenate, but less toxic than arsenite." | ( Effect of sulfide on the cytotoxicity of arsenite and arsenate in human hepatocytes (HepG2) and human urothelial cells (UROtsa). Dopp, E; Hinrichsen, S; Lohmayer, R; Planer-Friedrich, B; Zdrenka, R, 2014) | 0.4 |
| " While As induces adverse effects by decreasing DNA methylation and affecting protein 53 expression, Se induces adverse effects by modifying thioredoxin reductase." | ( Arsenic and selenium toxicity and their interactive effects in humans. Luo, J; Ma, LQ; Pu, LP; Rathinasabapathi, B; Sun, HJ; Wu, B, 2014) | 0.4 |
| "This study examines willingness to pay (WTP) in Bangladesh for arsenic (As) safe drinking water across different As-risk zones, applying a double bound discrete choice value elicitation approach." | ( Household's willingness to pay for arsenic safe drinking water in Bangladesh. Brouwer, R; Khan, NI; Yang, H, 2014) | 0.4 |
| "Exposure to toxic metals remains a widespread occupational and environmental problem in world." | ( Nanoencapsulation of DMSA monoester for better therapeutic efficacy of the chelating agent against arsenic toxicity. Babbar, AK; Flora, SJ; Kaushik, MP; Kushwaha, P; Lomash, V; Mathur, R; Mishra, AK; Pathak, U; Samim, M; Yadav, A, 2014) | 0.4 |
| "This study was undertaken to investigate combined toxic and genotoxic effects of cadmium (Cd) and arsenic (As) on white clover, a pollutant sensitive plant frequently used as environmental bioindicator." | ( The combined toxic and genotoxic effects of Cd and As to plant bioindicator Trifolium repens L. Citterio, S; Fumagalli, P; Gentili, R; Ghiani, A; Nguyen Van, T, 2014) | 0.4 |
| " All 39 wells producing water from red sediments provide safe water following the Bangladesh drinking water standard for As (50 μg/L) where mean and median values were less than the WHO guideline value of 10 μg/L." | ( Sediment color tool for targeting arsenic-safe aquifers for the installation of shallow drinking water tubewells. Ahmed, KM; Bhattacharya, P; Frape, SK; Hasan, MA; Hossain, M; Islam, MM; Jacks, G; Rahman, MM; von Brömssen, M, 2014) | 0.4 |
| " Analysis of fluorescein diacetate (FDA) hydrolysis activity revealed that roxarsone does not exert acute toxic on soil microbes." | ( Degradation of roxarsone in a silt loam soil and its toxicity assessment. Chen, G; Chen, Q; Ke, Z; Liang, T; Liu, L, 2014) | 0.4 |
| " Discussion of the health risk of As in rice has largely been based on its inorganic arsenic content because these species have generally been considered to be more toxic than MMA and DMA and can be directly compared to As in drinking water, assuming equal bioavailability of inorganic As in the rice matrix and in water." | ( Arsenic toxicity in rice with special reference to speciation in Indian grain and its implication on human health. Bhattacharyya, K; Sinha, B, 2015) | 0.42 |
| " Herein, "indirect" nanotoxicity is first defined as toxic amplification of toxicants or pollutants by nanomaterials." | ( Graphene oxide amplifies the phytotoxicity of arsenic in wheat. Hu, X; Kang, J; Lu, K; Mu, L; Zhou, Q; Zhou, R, 2014) | 0.4 |
| "Cardiotoxicity is an aggravating side effect of many clinical antineoplastic agents such as arsenic trioxide (As2O3), which is the first-line treatment for acute promyelocytic leukemia (APL)." | ( Arsenic trioxide and resveratrol show synergistic anti-leukemia activity and neutralized cardiotoxicity. Chen, M; Fan, Y; Fang, K; Meng, J; Tu, Y; Wan, L; Yu, L; Zhu, W, 2014) | 0.4 |
| " In addition, calcium phosphate used as the washing solution seemed to contribute more on the toxic effects of the washed soils than potassium phosphate and ammonium phosphate." | ( Changes in soil toxicity by phosphate-aided soil washing: effect of soil characteristics, chemical forms of arsenic, and cations in washing solutions. Im, J; Jho, EH; Kim, YJ; Nam, K; Yang, K, 2015) | 0.42 |
| "Arsenic is a metalloid that is toxic to living organisms." | ( Evaluation of arsenic trioxide genotoxicity in wheat seedlings using oxidative system and RAPD assays. Aksakal, O; Esim, N, 2015) | 0.42 |
| " Classic realgar-containing traditional Chinese medicine prescriptions, such as Niuhuang Jiedu tablet, shall be evaluated with rigorous modern scientific basis, with the aim to guide rational and safe application." | ( [Safety evaluation of niuhuang jiedu tablet]. Feng, YL; Li, J; Liu, J; Miao, JW; Sung, AS, 2014) | 0.4 |
| " The authors conclude that toad embryos are more sensitive to As during early developmental stages and that relatively high concentrations of this toxic element are required to elicit mortality, but oxidative stress may be an adverse effect at sublethal concentrations." | ( Acute toxicity of arsenic and oxidative stress responses in the embryonic development of the common South American toad Rhinella arenarum. Bongiovanni, GA; Ferrari, A; Lascano, CI; Mardirosian, MN; Venturino, A, 2015) | 0.42 |
| "Participants with elevated water arsenic levels were referred to the Florida Safe Water Restoration Program for assistance in obtaining bottled water vouchers and/or POU filters." | ( Using an environmental public health tracking biomonitoring study to validate safe water restoration efforts in Florida. Bonometti, MA; DuClos, C; Gray, A; Jordan, M; Kintziger, K, ) | 0.13 |
| "The current practice used by the Florida Safe Water Restoration Program of supplying POU filters or bottled water to households with arsenic levels in private wells between 10 and 50 μg/L appears to be sufficient to protect residents from arsenic exposure through tap water." | ( Using an environmental public health tracking biomonitoring study to validate safe water restoration efforts in Florida. Bonometti, MA; DuClos, C; Gray, A; Jordan, M; Kintziger, K, ) | 0.13 |
| "Mesoporous iron oxide, particularly amine-functionalized FeO(x) and FeO(x), was investigated for the removal of toxic heavy metal anions of arsenic and chromium from an aqueous solution." | ( Surface modified mesostructured iron oxyhydroxide: synthesis, ecotoxicity, and application. Choi, JW; Chung, SG; Kim, SB; Lee, SH; Mahendran, B, 2014) | 0.4 |
| "Inhibition of early steps of autophagy by 3-MA or Beclin 1 knockdown decreased the toxic effect of arsenic trioxide (ATO) in GBM cell lines." | ( Impact of autophagy inhibition at different stages on cytotoxic effect of autophagy inducer in glioblastoma cells. Bi, Y; Chen, X; Cho, K; Hou, X; Li, C; Liu, H; Liu, Y; Peng, F; Shen, C; Wang, K; Wang, X; Yang, Z; Zhang, J; Zhang, W; Zhang, X; Zhao, S; Zheng, Z; Zhong, C; Zou, H, 2015) | 0.42 |
| " The toxic effect of arsenic was also indicated by significantly decreased activities of enzymatic antioxidants such as superoxide dismutase, catalase, and glutathione peroxidase along with non-enzymatic antioxidant such as reduced glutathione." | ( Ameliorative efficacy of tetrahydrocurcumin against arsenic induced oxidative damage, dyslipidemia and hepatic mitochondrial toxicity in rats. Miltonprabu, S; Muthumani, M, 2015) | 0.42 |
| " The results of this study demonstrate that both arsenic and atrazine are potentially teratogenic and genotoxic, and can cause oxidative stress in zebrafish embryos, and these effects are potentiated by toxic interactions between the two contaminants." | ( Teratogenicity, genotoxicity and oxidative stress in zebrafish embryos (Danio rerio) co-exposed to arsenic and atrazine. Adeyemi, JA; Barbosa, F; da Cunha Martins-Junior, A, ) | 0.13 |
| " Hence, in the current review, we comprehensively try to intercalate the information on arsenic-induced epigenetic alterations of DNA, histones and microRNA so as to understand whether the arsenic-induced toxic manifestations are brought about by the epigenetic changes." | ( Epimutagenesis: A prospective mechanism to remediate arsenic-induced toxicity. Giri, AK; Paul, S, 2015) | 0.42 |
| "02 mM) was very effective in counteracting the adverse effect of As toxicity." | ( Nitric oxide mitigates arsenic-induced oxidative stress and genotoxicity in Vicia faba L. Shukla, P; Singh, AK, 2015) | 0.42 |
| "Arsenic (As) is a widely distributed trace element which is known to be associated with numerous adverse effects on human beings and animals." | ( The Role of Oxidative Stress in Gastrointestinal Tract Tissues Induced by Arsenic Toxicity in Cocks. Guo, G; Guo, Y; Hu, Z; Tian, L; Xing, M; Zhang, K; Zhang, W; Zhao, P, 2015) | 0.42 |
| " The broad scope of arsenic toxicity to humans and its unique interaction with the environment have led to extensive research into its physicochemical properties and toxic behavior in biological systems." | ( Arsenic: A Review of the Element's Toxicity, Plant Interactions, and Potential Methods of Remediation. Cañas-Carrell, JE; French, AD; Hettick, BE; Klein, DM, 2015) | 0.42 |
| " However, inorganic arsenic is more toxic than organic and can cause many diseases including cancers in humans." | ( Natural Antioxidants Against Arsenic-Induced Genotoxicity. Kumar, M; Lalit, M; Thakur, R, 2016) | 0.43 |
| "Theory-based interventions can enhance people's safe water consumption, but the sustainability of these interventions and the mechanisms of maintenance remain unclear." | ( Mechanisms of behavioural maintenance: Long-term effects of theory-based interventions to promote safe water consumption. Inauen, J; Mosler, HJ, 2016) | 0.43 |
| "In the field of toxicological bioassays, the latest progress in Raman spectroscopy opens new research perspectives on a fast method of observing metabolic responses against toxic agents." | ( Potential of Raman Spectroscopy To Monitor Arsenic Toxicity on Bacteria: Insights toward Multiparametric Bioassays. Assaf, A; Bittel, M; Cordella, CB; Durand, MJ; Jouanneau, S; Thouand, G, 2015) | 0.42 |
| " The results indicated that arsenate was highly toxic than arsenite to the alga, and the phosphate limitation in growth media greatly enhanced arsenate toxicity." | ( Influence of phosphate on toxicity and bioaccumulation of arsenic in a soil isolate of microalga Chlorella sp. Bahar, MM; Megharaj, M; Naidu, R, 2016) | 0.43 |
| " Study objectives were to: 1) define the lowest safe dose of arsenic trioxide that transiently blocks p53 activation in patients and 2) assess the potential of LDA to decrease hematological toxicity from chemotherapy." | ( p53-based strategy to reduce hematological toxicity of chemotherapy: A proof of principle study. Argiris, A; Crownover, RL; Elledge, R; Eng, TY; Ganapathy, S; Goros, M; Ha, CS; Jenkins, CA; Karnad, A; Kelly, KR; Michalek, JE; Pollock, BH; Su, H; Swanson, GP; Swords, R; Yuan, ZM, 2016) | 0.43 |
| " Pollutants responsible for toxicity were different depending on the tested organism, with arsenic being most toxic for lettuce and the metal mixture to soil respiration." | ( Long-term toxicity assessment of soils in a recovered area affected by a mining spill. García Fernández, I; Martín Peinado, FJ; Martínez Garzón, FJ; Romero-Freire, A; Simón Torres, M, 2016) | 0.43 |
| " Soybean seedling growth was significantly affected at 25 μM or higher concentrations of As(V) or As(III), and the toxic effect on root growth was associated with cell death of root tips." | ( Arsenic toxicity in soybean seedlings and their attenuation mechanisms. Agostini, E; Armendariz, AL; Reinoso, H; Talano, MA; Travaglia, C; Wevar Oller, AL, 2016) | 0.43 |
| " Interestingly, a metal like Pb becomes toxic to organisms through the depletion of antioxidants while Cd indirectly generates ROS by its ability to replace iron and copper." | ( A review of toxicity and mechanisms of individual and mixtures of heavy metals in the environment. Cobbina, SJ; Mao, G; Wu, X; Xu, H; Yang, L; Zhang, Z, 2016) | 0.43 |
| " A number of in vivo and in vitro studies showed that upregulated MT biosynthesis in blood components are related to toxic levels of As." | ( Arsenic Induction of Metallothionein and Metallothionein Induction Against Arsenic Cytotoxicity. De Ley, M; Rahman, MT, ) | 0.13 |
| " Lack of nutritious foods exacerbates the adverse health effects of arsenic poisoning." | ( A high-selenium lentil dietary intervention in Bangladesh to counteract arsenic toxicity: study protocol for a randomized controlled trial. Akhtar, E; Krohn, RM; Raqib, R; Smits, JE; Vandenberg, A, 2016) | 0.43 |
| "Selenium pills as a treatment for arsenic exposure are costly and inconvenient, whereas a whole food approach to lower the toxic burden of arsenic may be a practical remedy for Bangladeshi people while efforts to provide safe drinking water are continuing." | ( A high-selenium lentil dietary intervention in Bangladesh to counteract arsenic toxicity: study protocol for a randomized controlled trial. Akhtar, E; Krohn, RM; Raqib, R; Smits, JE; Vandenberg, A, 2016) | 0.43 |
| " The copepods were variably sensitive to As, Cr and Zn, with Cr being the most toxic across all taxa." | ( The toxicity of arsenic(III), chromium(VI) and zinc to groundwater copepods. Hose, GC; Lategan, MJ; Lott, MJ; Symington, K, 2016) | 0.43 |
| " This suggests that As may exert toxic effects in the nucleus, for example, by interfering with nucleic acid synthesis by replacing phosphorous with As." | ( Analysis of sublethal arsenic toxicity to Ceratophyllum demersum: subcellular distribution of arsenic and inhibition of chlorophyll biosynthesis. Alfeld, M; Andresen, E; Falkenberg, G; Küpper, H; Mishra, S; Sobotka, R, 2016) | 0.43 |
| " Composted and vermicomposted sludge mixtures showed surprisingly high toxicity on all three tested organisms despite the decrease in arsenic mobility, probably due to toxic metabolites of bacteria and earthworms produced during these processes." | ( Ecotoxicity of arsenic contaminated sludge after mixing with soils and addition into composting and vermicomposting processes. Hofman, J; Maňáková, B; Šudoma, M; Vašíčková, J, 2016) | 0.43 |
| "Arsenic (As) is a toxic element with the potential to cause health effects in humans." | ( Selenate mitigates arsenite toxicity in rice (Oryza sativa L.) by reducing arsenic uptake and ameliorates amino acid content and thiol metabolism. Dixit, G; Dwivedi, S; Kumar, A; Mishra, K; Singh, AP; Srivastava, S; Tripathi, RD, 2016) | 0.43 |
| "Arsenic is a widespread metalloid in environment, whose exposure has been associated with a broad spectrum of toxic effects." | ( Integrated proteomics and metabolomics analysis of rat testis: Mechanism of arsenic-induced male reproductive toxicity. Alamdar, A; Eqani, SA; Huang, Q; Liu, L; Luo, L; Shen, H; Tian, M; Zhang, J, 2016) | 0.43 |
| " In this paper, we reviewed studies on the toxicity of arsenic, lead, mercury and cadmium, the toxic metals of most concern to human health, focusing on the potential risks to newborns and infants." | ( Arsenic, lead, mercury and cadmium: Toxicity, levels in breast milk and the risks for breastfed infants. Caldas, ED; Rebelo, FM, 2016) | 0.43 |
| " Compared to inorganic arsenic, ROX was less toxic to wheat root elongation." | ( Phytotoxicity and uptake of roxarsone by wheat (Triticum aestivum L.) seedlings. Blaney, L; Fu, QL; Zhou, DM, 2016) | 0.43 |
| " Furthermore, the toxic effect induced by Sb was compared with As toxicity in regard to ROS generation and diffusional kinetics, which provides information on the protein aggregation process." | ( Mechanisms underlying the toxic effects of antimony species in human embryonic kidney cells (HEK-293) and their comparison with arsenic species. Ogra, Y; Quiroz, W; Verdugo, M, 2016) | 0.43 |
| " Interestingly, glutathione reductase activity was inhibited at a very low concentration of As considered safe for aquatic life." | ( Chronic toxicity of arsenic during Rhinella arenarum embryonic and larval development: Potential biomarkers of oxidative stress and antioxidant response. Bongiovanni, GA; Lascano, CI; Mardirosian, MN; Venturino, A, 2017) | 0.46 |
| "Many studies have demonstrated that heavy metals existing as a mixture in the atmospheric environment cause adverse effects on human health and are important key factors of cytotoxicity; however, little investigation has been conducted on a toxicological study of a metal mixture from atmospheric fine particulate matter." | ( Combined toxic effect of airborne heavy metals on human lung cell line A549. Choi, Y; Kim, I; Kim, SD; Park, K, 2018) | 0.48 |
| " These results suggest that DPAA is toxic to the bile duct epithelium in rats." | ( A chronic toxicity study of diphenylarsinic acid in F344 rats in drinking water for 52 weeks. Doi, K; Fujioka, M; Gi, M; Ishii, N; Kakehashi, A; Kawachi, S; Tatsumi, K; Wanibuchi, H; Yamaguchi, T; Yamano, S, 2017) | 0.46 |
| "78, indicating that these contaminants are developmentally toxic at lower concentrations when exposed as a mixture." | ( Developmental and interactive effects of arsenic and chromium to developing Ambystoma maculatum embryos: Toxicity, teratogenicity, and whole-body concentrations. Cline, G; Gardner, S; Mwebi, N; Rayburn, J, 2017) | 0.46 |
| "Arsenic (As) is a toxic metalloid." | ( Arsenic uptake, accumulation and toxicity in rice plants: Possible remedies for its detoxification: A review. Abbas, F; Abbas, S; Alharby, H; Bakhat, HF; Fahad, S; Hammad, HM; Shahid, M; Shahzad, AN; Zia, Z, 2017) | 0.46 |
| "Herbo-mineral preparations of arsenic kushta are nephrotoxic in rats and may have similar toxic effects in human beings." | ( Histopathological Changes in Arsenic Kushta Induced Nephrotoxicity in Wistar Rats. Javaid, QU; Nagi, AH; Naseem, N; Shafique, S, 2017) | 0.46 |
| "Arsenic-containing hydrocarbons (AsHCs), natural products found in seafood, have recently been shown to exert toxic effects in human neurons." | ( Arsenolipids exert less toxicity in a human neuron astrocyte co-culture as compared to the respective monocultures. Bornhorst, J; Ebert, F; Francesconi, KA; Meyer, S; Mitze, H; Schwerdtle, T; Witt, B, 2017) | 0.46 |
| "Arsenic (As) is a toxic environmental contaminant and potential human carcinogen." | ( Identification of potential biomarkers of hepatotoxicity by plasma proteome analysis of arsenic-exposed carp Labeo rohita. Banerjee, S; Cash, P; Mahanty, A; Mazumder, DG; Mohanty, BP; Mohanty, S, 2017) | 0.46 |
| " Over the past decade, evidence indicated that As-induced epigenetic modifications have a role in the adverse effects on human health." | ( Effects of arsenic toxicity beyond epigenetic modifications. Aaseth, J; Bjørklund, G; Chirumbolo, S; Uddin, R; Urbina, MA, 2018) | 0.48 |
| " Of the various high throughput technologies available to detect global methylation profile, development of LINE-1 methylation index shall provide a cost effect-screening tool to detect epimutagenic events in the wake of toxic exposure in a large number of individuals." | ( Arsenic toxicity and epimutagenecity: the new LINEage. Bhattacharjee, P; Giri, AK; Paul, S, 2017) | 0.46 |
| " Experiments using the model system Arabidopsis thaliana showed that monothioarsenate is less toxic than arsenite, but more toxic than arsenate at concentrations ≥25 μM As, reflected in stronger seedling growth inhibition on agar plates." | ( Thioarsenate Toxicity and Tolerance in the Model System Arabidopsis thaliana. Clemens, S; Halder, D; Kühnlenz, T; Lohmayer, R; Planer-Friedrich, B; Rafferty, C; Wilson, N, 2017) | 0.46 |
| "Arsenic is a widespread metalloid in the environment, which poses a broad spectrum of adverse effects on human health." | ( Comparative proteomic analysis reveals heart toxicity induced by chronic arsenic exposure in rats. Alamdar, A; Huang, Q; Shen, H; Xi, G; Zhang, J, 2017) | 0.46 |
| " Chronic As intoxication leads to undesirable toxic effects in various organ systems of the body, especially the kidney." | ( Diallyl trisulfide, a garlic polysulfide protects against As-induced renal oxidative nephrotoxicity, apoptosis and inflammation in rats by activating the Nrf2/ARE signaling pathway. Miltonprabu, S; Senthilraja, P; Sumedha, NC, 2017) | 0.46 |
| "This article reviewed epigenetic mechanisms underlying the toxic effects associated with arsenic exposure and the development of diabetes." | ( Epigenetic mechanisms underlying the toxic effects associated with arsenic exposure and the development of diabetes. Abdollahi, M; Hassan, FI; Khan, F; Momtaz, S; Niaz, K, 2017) | 0.46 |
| " The future research opportunities mentioned in the conclusion of review will help researchers to explore new avenues, methodologies, and approaches to the issue of heavy metal(loid)s in complementary medicines, thereby generating new regulations and proposing fresh approach towards safe use of these medicines." | ( Sources, distribution, bioavailability, toxicity, and risk assessment of heavy metal(loid)s in complementary medicines. Bolan, NS; Bolan, S; Choppala, G; Kirkham, MB; Kunhikrishnan, A; Li, CG; Li, F; Naidu, R; Noller, B; Ok, YS; Seshadri, B; Zhang, M, 2017) | 0.46 |
| " The toxic effect of blackgram depends on the genotypic variability." | ( Effects of arsenic toxicity on morphological characters in blackgram (Vigna mungo L.) during early growth stage. Pandey, A; Shamim, MZ, 2017) | 0.46 |
| "Heavy metals are considered some of the most toxic environmental pollutants." | ( Comparative In Vitro Toxicity Evaluation of Heavy Metals (Lead, Cadmium, Arsenic, and Methylmercury) on HT-22 Hippocampal Cell Line. Karri, V; Kumar, V; Oliveira, E; Ramos, D; Schuhmacher, M, 2018) | 0.48 |
| " In addressing key issues of reducing toxic side effects and improving pharmacokinetic profiles of the therapeutic agents, we have developed a new formulation by co-packaging DAC and ATO into alendronate-conjugated bone-targeting nanoparticles (BTNPs)." | ( Bone-targeting nanoparticle to co-deliver decitabine and arsenic trioxide for effective therapy of myelodysplastic syndrome with low systemic toxicity. Ferrari, M; Hu, Z; Nizzero, S; Ramirez, MR; Shen, H; Shi, C; Wu, X; Zhang, G; Zhou, J, 2017) | 0.46 |
| " The bioaccessible fraction was first determined through online leaching of rice minicolumns (maintained at 37 °C) sequentially with artificial saliva, gastric juice, and intestinal juice while continuously monitoring potentially toxic elements (As, Cr, and Se) by inductively coupled plasma mass spectrometry (ICPMS)." | ( Simultaneous Speciation Analysis of Arsenic, Chromium, and Selenium in the Bioaccessible Fraction for Realistic Risk Assessment of Food Safety. Beauchemin, D; Sadiq, NW, 2017) | 0.46 |
| "Environmental contamination with arsenic (As) is a global environmental, agricultural and health issue due to the highly toxic and carcinogenic nature of As." | ( Arsenic Uptake, Toxicity, Detoxification, and Speciation in Plants: Physiological, Biochemical, and Molecular Aspects. Abbas, G; Amjad, M; Bibi, I; Hussain, M; Khan, MI; Murtaza, B; Niazi, NK; Shahid, M, 2018) | 0.48 |
| " Then quantitative analyses together with a battery of bioassays were performed to evaluate toxic effects." | ( Toxicity assessment of sediments from the Liaohe River Protected Area (China) under the influence of ammonia nitrogen, heavy metals and organic contaminants. Bao, Q; Huang, X; Ke, X; Qi, Y; Zhang, H, 2018) | 0.48 |
| "Chronic arsenic exposure is associated with increased risk for arsenical skin lesions, cancer, and other adverse health outcomes." | ( A study of telomere length, arsenic exposure, and arsenic toxicity in a Bangladeshi cohort. Ahmed, A; Ahsan, H; Delgado, D; Eunus, M; Gao, J; Graziano, JH; Hasan, R; Islam, MT; Islam, T; Jasmine, F; Kibriya, MG; Pierce, BL; Roy, S; Sabarinathan, M; Shinkle, J; Zhang, C, 2018) | 0.48 |
| " This study sought to determine the extent of contamination, bioaccumulation, and biomagnification in the resident bird community and therefore to infer the potential for adverse effects in birds." | ( Metal and Isotope Analysis of Bird Feathers in a Contaminated Estuary Reveals Bioaccumulation, Biomagnification, and Potential Toxic Effects. Coughanowr, C; Einoder, LD; MacLeod, CK, 2018) | 0.48 |
| " The adverse effects that these compounds exert on health are quite complex and difficult to elucidate, in that they act at different levels and there are various signaling pathways that are implicated in the mechanisms of damage." | ( Toxic Effect of Cadmium, Lead, and Arsenic on the Sertoli Cell: Mechanisms of Damage Involved. Bassol-Mayagoitia, S; Hernández-Ibarra, JA; Nava-Hernández, MP; Ramos-Treviño, J; Ruiz-Flores, P, 2018) | 0.48 |
| " Overall, the present study showed that U was the most toxic element, followed by As and Ni; that juveniles were more sensitive to the 3 metals tested than adults; and that threshold body concentrations can support assessment of benthic invertebrate community impairment." | ( Bioaccumulation and toxicity of uranium, arsenic, and nickel to juvenile and adult Hyalella azteca in spiked sediment bioassays. Goulet, RR; Thompson, P, 2018) | 0.48 |
| " The current evidence strongly suggests that low to moderate doses of arsenic induces toxic effects in the developing T cells and accumulates to highest levels in the early cells that are least capable to pump out arsenic, which may be the mechanism of the high arsenic sensitivity." | ( Toxicity of environmentally-relevant concentrations of arsenic on developing T lymphocyte. Burchiel, SW; Wang, X; Xu, H, 2018) | 0.48 |
| " Interestingly, oilseed rape accumulated seven times higher levels of lead than corn without showing adverse effects on productivity." | ( Phytotoxicity of polymetallic mine wastes from southern Tuscany and Saxony. Ancora, S; Büttner, P; Fangmeier, A; Fongoh, AH; Franzaring, J; Monaci, F; Paoli, L; Schlosser, S, 2018) | 0.48 |
| " The current proteomics analysis of three metals support the insight into the proteins involved in neurodegeneration and the altered proteins can be useful for metal-specific biomarkers of exposure and its adverse effects." | ( Differential protein expression of hippocampal cells associated with heavy metals (Pb, As, and MeHg) neurotoxicity: Deepening into the molecular mechanism of neurodegenerative diseases. Coort, SL; Evelo, CT; Karri, V; Kumar, V; Mariman, ECM; Martinez, JB; Odena, A; Oliveira, E; Ramos, D; Schuhmacher, M, 2018) | 0.48 |
| " Hereby, the molecular information provided by pathway and gene functional analysis can be used to develop a more thorough understanding of each metal mechanism at the protein level for different neurological adverse outcomes (e." | ( Differential protein expression of hippocampal cells associated with heavy metals (Pb, As, and MeHg) neurotoxicity: Deepening into the molecular mechanism of neurodegenerative diseases. Coort, SL; Evelo, CT; Karri, V; Kumar, V; Mariman, ECM; Martinez, JB; Odena, A; Oliveira, E; Ramos, D; Schuhmacher, M, 2018) | 0.48 |
| " Reduced antioxidant indices and increased hepatic damage biomarkers with pronounced histopathological alterations in hepatic tissue after combined exposure to toxicants indicate potentiating toxic effect of As on IMI-induced hepatotoxicity." | ( Toxic effects of imidacloprid combined with arsenic: Oxidative stress in rat liver. Mahajan, L; Raina, R; Sood, S; Verma, PK, 2018) | 0.48 |
| " In the past, much emphasis was laid on evaluating the toxic effects of a single chemical." | ( Potentiating effect of imidacloprid on arsenic-induced testicular toxicity in Wistar rats. Mahajan, L; Raina, R; Sood, S; Verma, PK, 2018) | 0.48 |
| "The toxic metalloid arsenic (As) is consumed mostly through contaminated rice." | ( Selenium amelioration of arsenic toxicity in rice shows genotypic variation: A transcriptomic and biochemical analysis. Gupta, M; Pandey, C, 2018) | 0.48 |
| "The mammalian gut microbiome (GM) plays a critical role in xenobiotic biotransformation and can profoundly affect the toxic effects of xenobiotics." | ( Gut microbiome disruption altered the biotransformation and liver toxicity of arsenic in mice. Chi, L; Lai, Y; Lu, K; Ru, H; Tu, P; Xue, J, 2019) | 0.51 |
| " It can be concluded that the mixed culture has great potential to ameliorate rice from As toxicity by preventing As species entry into rice for enhancing rice growth and also for reducing As accumulation to produce safe rice from rice grown in contaminated paddy fields." | ( Reduction in arsenic toxicity and uptake in rice (Oryza sativa L.) by As-resistant purple nonsulfur bacteria. Kantachote, D; Megharaj, M; Naidu, R; Nookongbut, P, 2018) | 0.48 |
| "7 mg/kg realgar for 2 weeks, there will be no adverse reactions." | ( Study of the accumulation and distribution of arsenic species and association with arsenic toxicity in rats after 30 days of oral realgar administration. Gao, S; Ji, S; Li, C; Liang, A; Xia, J; Yi, Y; Zhang, Y; Zhao, Y, 2020) | 0.56 |
| " Some phytochemicals through their antioxidant properties might help to overcome such toxic effects." | ( Ellagic and ferulic acids protect arsenic-induced male reproductive toxicity via regulating Nfe2l2, Ppargc1a and StAR expressions in testis. Arangasamy, A; Guvvala, PR; Ravindra, JP; Selvaraju, S; Venkata, KM, 2019) | 0.51 |
| " The environment contaminants cause severe adverse effects to humans, flora and fauna that are mostly irreversible." | ( An overview of plant-based interventions to ameliorate arsenic toxicity. Krishnan, UM; Rajendran, K; Sathyasivam, K; Susan, A, 2019) | 0.51 |
| " The memory effect might play key roles in increased tolerance of the A549 and HeLa cells to adverse effects (cell viability, intracellular reactive oxygen species (ROS) generation and plasma membrane damage) induced by titanium dioxide nanoparticles (as representative pollutant)." | ( Memory effect of arsenic-induced cellular response and its influences on toxicity of titanium dioxide nanoparticle. Liu, S; Shen, Z; Wu, B; Yu, Y, 2019) | 0.51 |
| " We believe that dietary salt products are safe at retail, and the long-term dietary exposure of cooking salts will not pose any significant health risk." | ( Is the Cooking Salt Safe in China? Assessment of Chemical Contaminants in Cooking Salt. Jia, X; Wang, Z; Zhou, J, 2019) | 0.51 |
| " This study examined the toxic effects of arsenic and zinc on Eastern oysters, their interaction and resulting enzymatic responses." | ( Toxicity of As in Crassostrea virginica (Gmelin, 1791) from the Northern Gulf of Mexico at the presence of Zn and its antioxidant defense mechanisms. Alexander, TC; Arslan, Z; Han, FX; Tchounwou, PB, 2019) | 0.51 |
| " Two major genetic factors that are discussed include genetic polymorphisms in plasma membrane transporters that catalyze uptake and accumulation or efflux and elimination of environmental chemicals, and genetic polymorphisms in bioactivation enzymes that generate toxic and reactive metabolites." | ( Environmental and Genetic Factors Influencing Kidney Toxicity. Lash, LH, 2019) | 0.51 |
| " It also has an exceptionally narrow range between necessary and toxic concentrations, which is a well-known hindrance in its use as a dietary supplement." | ( The Role of Selenium in Arsenic and Cadmium Toxicity: an Updated Review of Scientific Literature. Zwolak, I, 2020) | 0.56 |
| " For the pellet diet experiment, MMA and DMA were found to be at least an order of magnitude less toxic than inorganic As on the basis of concentration in the diet, as well as much less toxic on the basis of accumulation in the fish." | ( The effects of arsenic speciation on accumulation and toxicity of dietborne arsenic exposures to rainbow trout. Erickson, RJ; Highland, TL; Hockett, JR; Hoff, DJ; Jenson, CT; Lahren, TJ; Mount, DR, 2019) | 0.51 |
| " Following randomised trypanocidal treatment (diminazene diaceturate, melarsomine dihydrochloride or isometamidium chloride), animals were observed for immediate adverse drug reactions and follow-up assessment was performed at 1 and 2 weeks." | ( Safety and efficacy of three trypanocides in confirmed field cases of trypanosomiasis in working equines in The Gambia: a prospective, randomised, non-inferiority trial. Jallow, S; Raftery, AG; Rodgers, J; Sutton, DGM, 2019) | 0.51 |
| " To this end, we designed an ecotoxicity test using an aquatic midge, Chironomus riparius, raised in metal-contaminated field sediments (MCFS), which reflect the real environmental conditions, for five consecutive generations (F0-F4) followed by a toxic response to arsenic exposure (as a second challenge)." | ( Genetic, epigenetic, and developmental toxicity of Chironomus riparius raised in metal-contaminated field sediments: A multi-generational study with arsenic as a second challenge. Chatterjee, N; Choi, J; Im, J, 2019) | 0.51 |
| " Functionalization changed the toxic effects of the SWCNTs, and different influence was found between long SWCNTs and short SWCNTs." | ( Comparison of cytotoxicity and membrane efflux pump inhibition in HepG2 cells induced by single-walled carbon nanotubes with different length and functional groups. Jiang, W; Liu, S; Nurmamat, H; Shen, Z; Wu, B; Wu, J; Yu, Y, 2019) | 0.51 |
| " Decomposing forest litter can affect mobilization of As and other toxic elements, change their speciation in pore water and influence the toxicity to biota." | ( Ecotoxicity of pore water in soils developed on historical arsenic mine dumps: The effects of forest litter. Dradrach, A; Karczewska, A; Szopka, K, 2019) | 0.51 |
| "Methylmercury (MeHg), cadmium (Cd) and arsenic (As(III)) are among the most toxic metals in aquatic systems that have been associated with multiple animal and human health problems." | ( Methylmercury, cadmium and arsenic(III)-induced toxicity, oxidative stress and apoptosis in Pacific red snapper leukocytes. Angulo, C; Cruz, A; Cuesta, A; Reyes-Becerril, M; Sanchez, V, 2019) | 0.51 |
| "Natural processes and human activities have caused widespread background contamination with non-essential toxic elements." | ( Safer food through plant science: reducing toxic element accumulation in crops. Clemens, S, 2019) | 0.51 |
| "Arsenic is awfully toxic metalloid responsible for many human diseases all over the world." | ( Investigating the protective actions of D-pinitol against arsenic-induced toxicity in PC12 cells and the underlying mechanism. Akter, M; Hosokawa, T; Kurasaki, M; Rahaman, MS; Rahman, MM; Saito, T; Sikder, MT, 2020) | 0.56 |
| " Unlike acute toxic exposure, the classical dose-response relationship is not adequate for estimating the possible impact of chronic low-level arsenic exposure." | ( Developmental toxicity of arsenic: a drift from the classical dose-response relationship. Aaseth, J; Bjørklund, G; Rahaman, MS; Tippairote, T, 2020) | 0.56 |
| " Analyses of eleven oxidative stress and antioxidant parameters showed all Pb, Cd and As induced oxidative damages, and the co-exposure further enhanced their toxic effects." | ( Combined toxicity and detoxification of lead, cadmium and arsenic in Solanum nigrum L. Cui, X; Cui, Z; Li, X; Liu, W; Zhang, X, 2020) | 0.56 |
| "Heavy metals and herbicide are gaining serious environmental concern in aquatic toxicology due to its adverse effects on aquatic organisms especially amphibians." | ( Acute toxicity assessment of arsenic, chromium and almix 20WP in Euphlyctis cyanophlyctis tadpoles. Ghosh, AR; Mukherjee, AK; Pal, S; Samanta, P, 2020) | 0.56 |
| " Recent studies show that it has also toxic effects on the intestinal epithelium which might partly explain its systemic toxicity." | ( In Vitro Evaluation of the Protective Role of Lactobacillus StrainsAgainst Inorganic Arsenic Toxicity. de Matuoka E Chiocchetti, G; Devesa, V; Monedero, V; Vélez, D; Zúñiga, M, 2020) | 0.56 |
| " Furthermore, the AsHCs were several fold more potent as compared to the toxic reference arsenite." | ( Toxicity of three types of arsenolipids: species-specific effects in Caenorhabditis elegans. Aschner, M; Baesler, J; Bornhorst, J; Ebert, F; Feldmann, J; Francesconi, K; Guttenberger, N; Meyer, S; Raab, A; Raber, G; Schwerdtle, T; Xiong, C; Ziemann, V, 2020) | 0.56 |
| " One working tubewell that had been tested previously for arsenic and marked safe (green) was selected from each unions of the district." | ( Human health risk assessment of elevated and variable iron and manganese intake with arsenic-safe groundwater in Jashore, Bangladesh. Chakraborty, TK; Ghosh, GC; Kabir, AHME; Khan, MJH; Tanaka, H; Zaman, S, 2020) | 0.56 |
| " Recombinant human PEDF treatment (100 nM) prevented the toxic effects of arsenite (50 μM) on endothelial cells in vitro by increasing NO content, decreasing reactive oxygen species (ROS) levels, and inhibiting apoptosis, as well as increasing cell viability and decreasing levels of P53 and phospho-p38." | ( Pigment epithelium-derived factor (PEDF) ameliorates arsenic-induced vascular endothelial dysfunction in rats and toxicity in endothelial EA.hy926 cells. Fu, X; Guo, X; Jackson, S; Li, J; Liu, X; Sun, D; Wang, J; Yao, J; Zhang, W; Zhang, X, 2020) | 0.56 |
| " This article reviews current scientific findings on health-related issues on drinking water and discusses the challenges for safe and healthy drinking water in China." | ( Challenges for Safe and Healthy Drinking Water in China. Wu, J, 2020) | 0.56 |
| " According to literature, water scarcity is still a severe ongoing issue, and regional disparity affects the access to safe and healthy drinking water." | ( Challenges for Safe and Healthy Drinking Water in China. Wu, J, 2020) | 0.56 |
| "Recently, epidemiological studies have suggested that fluoride is a human developmental neurotoxicant that reduces measures of intelligence in children, placing it into the same category as toxic metals (lead, methylmercury, arsenic) and polychlorinated biphenyls." | ( Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses. Degen, G; Diel, P; Edlund, K; Eisenbrand, G; Engel, KH; Epe, B; Grune, T; Guth, S; Heinz, V; Hengstler, JG; Henle, T; Humpf, HU; Hüser, S; Jäger, H; Joost, HG; Kulling, SE; Lampen, A; Mally, A; Marchan, R; Marko, D; Mühle, E; Nitsche, MA; Nöthlings, U; Röhrdanz, E; Roth, A; Stadler, R; van Thriel, C; Vieths, S; Vogel, RF; Wascher, E; Watzl, C, 2020) | 0.56 |
| "Arsenic is a recognized highly toxic contaminant, responsible for numerous human diseases and affecting many millions of people in different parts of the world." | ( Curcumin alleviates arsenic-induced toxicity in PC12 cells via modulating autophagy/apoptosis. Akter, M; Banik, S; Hosokawa, T; Kurasaki, M; Rahaman, MS; Rahman, MM; Saito, T; Sikder, MT, 2020) | 0.56 |
| " Six different indices of toxic doses were compared to evaluate their accuracy in describing the field response expressed as relative abundance and cover." | ( Validating the Use of a Toxicity Database for Prediction of Plant Cover and Biodiversity in Multi-Metal Mining-Impacted Soils. Guzmán-Rangel, G; Oorts, K; Pavón Meza, EL; Smolders, E; Torres Díaz, AN, 2020) | 0.56 |
| " The associated toxic metal-mediated mechanisms of male reproductive toxicity include ion mimicry, disruption of cell signaling pathways, oxidative stress, altered gene expression, epigenetic regulation of gene expression, apoptosis, disruption of testis/blood barrier, inflammation and endocrine disruption." | ( Current mechanistic perspectives on male reproductive toxicity induced by heavy metals. Anyanwu, BO; Orisakwe, OE, 2020) | 0.56 |
| " Chronic toxicity bioassays were more sensitive than acute toxicity tests for determining the adverse effect of As to rotifers." | ( Effect of salinity and temperature on the acute and chronic toxicity of arsenic to the marine rotifers Proales similis and Brachionus ibericus. Arreguin Rebolledo, U; Escobar-Sánchez, O; Nandini, S; Sarma, SSS, 2020) | 0.56 |
| " Long-term exposure to arsenic has strong adverse health effects on liver and kidney disorders, and various forms of cancer." | ( Effects of curcumin, D-pinitol alone or in combination in cytotoxicity induced by arsenic in PC12 cells. Binte Hossain, KF; Hosokawa, T; Kurasaki, M; Rahaman, MS; Saito, T; Yamasaki, S, 2020) | 0.56 |
| " Cadmium, mercury, lead, and arsenic are nonessential toxic heavy metals that are most frequently involved in environmental and health hazards." | ( The Role of Spirulina (Arthrospira) in the Mitigation of Heavy-Metal Toxicity: An Appraisal. Bhattacharya, S, 2020) | 0.56 |
| " It causes toxic effects on different organs, mainly the liver." | ( An appraisal on molecular and biochemical signalling cascades during arsenic-induced hepatotoxicity. Abel, P; Annamalai, S; Balachandar, V; Elangovan, A; Madhyastha, H; Madhyastha, R; Maruyama, M; Namachivayam, A; Ramesh, S; Renu, K; Saravanan, A; Valsala Gopalakrishnan, A, 2020) | 0.56 |
| " Synthetic chelators impart a major drawback of removing essential metals required for normal body function, along with the toxic one." | ( Metal toxicity and natural antidotes: prevention is better than cure. Parashar, P; Rajak, C; Singh, N, 2020) | 0.56 |
| "Arsenic (As) exposure is associated with adverse health outcomes to the living organisms." | ( Protective efficacy of thymoquinone or ebselen separately against arsenic-induced hepatotoxicity in rat. Abdel Moneim, AE; Al Aboud, D; Alsharif, KF; Amin, HK; Baty, RS; Elmahallawy, EK; Habotta, OA; Hassan, KE; Kassab, RB; Zhery, AS, 2021) | 0.62 |
| "Irrigation water contaminated with arsenic acts as a potent source of contamination to humans through water-soil-crop-food transfer so quantification of safe limit for irrigation water is also critical." | ( Determination of safe limit for arsenic contaminated irrigation water using solubility free ion activity model (FIAM) and Tobit Regression Model. Ghosh, M; Kumar, R; Kumari, PB; Mandal, J; Raj, A; Sadhu, SK; Shambhavi, S; Singh, M; Singh, YK, 2021) | 0.62 |
| " This study investigated the toxic effect of As on pulpal-like cells and evaluated the influence of reduced glutathione (GSH) on As-induced toxicity." | ( In Vitro Mitigation of Arsenic-Induced Toxicity by Reduced Glutathione in Rat Pulp Cells. Dargham, A; Hiraishi, N; Nassar, M; Tagami, J; Tamura, Y, 2020) | 0.56 |
| " As elicited remarkable toxic effect on pulpal cells, while 5000 µM GSH protected the cells from As-induced damage at 24-hour exposure time." | ( In Vitro Mitigation of Arsenic-Induced Toxicity by Reduced Glutathione in Rat Pulp Cells. Dargham, A; Hiraishi, N; Nassar, M; Tagami, J; Tamura, Y, 2020) | 0.56 |
| "Arsenic is a highly toxic environmental pollutant that is abundant in waters around the world." | ( Ameliorative effect of graphene nanosheets against arsenic-induced toxicity in mice by oral exposure. Chen, L; Li, H; Liu, S; Wu, B; Yu, Y; Zhang, J, 2021) | 0.62 |
| " Arsenic, a toxic metalloid known as an environmental pollutant, readily contaminates drinking water and exerts toxic effects." | ( Mitochondrial Dysfunction in Arsenic-Induced Hepatotoxicity: Pathogenic and Therapeutic Implications. Chhikara, S; Kumar, V; Prakash, C, 2022) | 0.72 |
| "Introduction: Arsenic is an environmental toxic present worldwide." | ( Experimental acute arsenic toxicity in Balb/c mice: organic markers and splenic involvement Canalis, AM; Falchini, GE; Pérez, RD; Soria, EA, 2021) | 0.62 |
| " Non-essential heavy metals such as mercury (Hg), arsenic (As), cadmium (Cd), and aluminium (Al) are useless to organisms and have shown extensive toxic effects." | ( Metal-metal interaction and metal toxicity: a comparison between mammalian and Tian, X; Wang, Y; Yu, X; Zhu, C, 2021) | 0.62 |
| " Researchers in the field commonly find mouse models and humans behaving very differently upon exposure to acute and chronic arsenic, including drug therapies which seem safe in mice but are toxic in humans." | ( Telomere Length and Arsenic: Improving Animal Models of Toxicity by Choosing Mice With Shorter Telomeres. Whitlock, B, ) | 0.13 |
| "Arsenic (As) is a toxic metalloid and its widespread contamination in agricultural soils along with soil salinization has become a serious concern for human health and food security." | ( Biochar mitigates arsenic-induced human health risks and phytotoxicity in quinoa under saline conditions by modulating ionic and oxidative stress responses. Abbas, G; Ali, S; Imran, M; Murtaza, G; Naeem, MA; Rashad Javeed, HM; Rizwan, M; Saqib, M; Shabbir, A, 2021) | 0.62 |
| "Anthropogenic activities, geological processes, and biogenic sources have led to the enhanced concentration of arsenic (As), a toxic metalloid in water and soil." | ( Safe, efficient, and economically beneficial remediation of arsenic-contaminated soil: possible strategies for increasing arsenic tolerance and accumulation in non-edible economically important native plants. Misra, AN; Sharma, P; Singh, R, 2021) | 0.62 |
| "The toxic metalloid arsenic causes widespread misfolding and aggregation of cellular proteins." | ( Genome-wide imaging screen uncovers molecular determinants of arsenite-induced protein aggregation and toxicity. Andersson, S; Ashouri, A; Becker, N; Hao, X; Hua, S; Jacobson, T; Karl, V; Liu, B; Nyström, T; Rauch, S; Rodrigues, JI; Romero, A; Tamás, MJ, 2021) | 0.62 |
| " It is imperative to establish accurate soil thresholds based on soil-plant transfer models and food safety standards for safe agricultural production." | ( Derivation and validation of thresholds of cadmium, chromium, lead, mercury and arsenic for safe rice production in paddy soil. Gao, J; Jiang, Y; Li, D; Ma, Y; Sun, B; Wang, X; Ye, X, 2021) | 0.62 |
| "Arsenic (As), cadmium (Cd), lead (Pb), mercury (Hg), beryllium (Be), nickel (Ni), selenium (Se), and thallium (Tl) are reportedly notorious toxic contents of make-ups, with potential to cause cancer and chronic kidney disease, warranting investigation on their toxic effects." | ( Toxic effects of selected trace elements contained in make-ups on female university students in Nigeria. Eneh, OC, 2021) | 0.62 |
| " Model compounds experiments illustrate that over 30% of the As(V) in feedstocks was unexpectedly converted into more soluble and toxic As (III)." | ( Hydrothermal liquefaction accelerates the toxicity and solubility of arsenic in biowaste. Cao, M; Li, H; Liu, Z; Zhang, Y, 2021) | 0.62 |
| " Arsenic is a non-essential metalloid for plants and can be acclimatised in plants to toxic levels." | ( Arsenic acquisition, toxicity and tolerance in plants - From physiology to remediation: A review. Bali, AS; Sidhu, GPS, 2021) | 0.62 |
| "Arsenic is a toxic metalloid that is widely distributed in the environment due to its persistence and accumulative properties." | ( Toxicity mechanisms of arsenic compounds in aquatic organisms. Byeon, E; Kang, HM; Lee, JS; Yoon, C, 2021) | 0.62 |
| " Moreover, the toxic effect of arsenic oxide nanoparticles (As-NPs) on plants and possible mechanisms for its alleviation has not yet been explored." | ( Soil enrichment with actinomycete mitigates the toxicity of arsenic oxide nanoparticles on wheat and maize growth and metabolism. AbdElgawad, H; Abuelsoud, W; Alsharari, SS; Atif, M; Hagagy, N; Madany, MMY; Selim, S; Warrad, M, 2021) | 0.62 |
| "Arsenic (As) is a ubiquitous metalloid that is highly toxic to all living organisms." | ( Arsenic transport and interaction with plant metabolism: Clues for improving agricultural productivity and food safety. Allakhverdiev, SI; Brestic, M; Hamza, A; Hussain, S; Shabala, S; Tahir, MA; Ulhassan, Z; Xie, Z; Yu, M; Zhang, J, 2021) | 0.62 |
| " Therefore, considering all these positive effects of melatonin, this review is aimed at melatonin supplementation therapy on arsenic toxicity which seems to be a suitable therapeutic agent to eliminate the adverse effects of arsenic." | ( Melatonin: a pleiotropic hormone as a novel potent therapeutic candidate in arsenic toxicity. Abdollahzade, N; Babri, S; Majidinia, M, 2021) | 0.62 |
| "Arsenic (As) is recognized as a toxic metalloid and a severe threat to biodiversity due to its contamination." | ( A comprehensive review of adaptations in plants under arsenic toxicity: Physiological, metabolic and molecular interventions. Aftab, T; Ahmad, P; Khan, MMA; Nabi, A; Naeem, M, 2021) | 0.62 |
| "Arsenic (As), a toxic trace element, is of great environmental concern due to its presence in soil, water, plant, animal and human continuum." | ( Risk Assessment of Arsenic Toxicity Through Groundwater-Soil-Rice System in Maldah District, Bengal Delta Basin, India. Chatterjee, N; Ghosh Bag, A; Hazra, GC; Khanam, R; Kulsum, PGPS; Shukla, AK, 2021) | 0.62 |
| " Salvinia was recorded with significant bioaccumulation of those metals with de-folding of cellular attributes in sustenance under toxic environment." | ( Amelioration of sodium and arsenic toxicity in Salvinia natans L. with 2,4-D priming through physiological responses. Adak, MK; Dolui, D; Ghosh, A; Hasanuzzaman, M; Saha, I, 2022) | 0.72 |
| " The present review focuses on the epidemiology, and the toxic mechanisms responsible for arsenic induced neurobehavioral diseases, including strategies for its management from water, community and household premises." | ( Molecular Mechanism of Arsenic-Induced Neurotoxicity including Neuronal Dysfunctions. Datusalia, AK; Flora, SJS; Niyogi, S; Rachamalla, M; Thakur, M, 2021) | 0.62 |
| "The inessential heavy metal/loids cadmium (Cd) and arsenic (As), which often co-occur in polluted paddy soils, are toxic to rice." | ( Comparative physiological and transcriptomic analyses illuminate common mechanisms by which silicon alleviates cadmium and arsenic toxicity in rice seedlings. Chen, H; Gong, X; Li, F; Liang, X; Liu, C; Liu, X; Reinfelder, JR; Sun, C; Yi, J; Zhang, S; Zhao, J, 2021) | 0.62 |
| "The results of the present study showed that use of spirulina could alleviate the toxic effects on the heart following exposure to arsenic toxicity." | ( Potential Protective Effect of Spirulina Platensis on Sodium Arsenite Induced Cardiotoxicity in Male Rats. Al-Naymat, W; Al-Qaitat, A; Albtoosh, A; Karawya, F, 2022) | 0.72 |
| " Data show that arsenic-protein interactions affect multiple cellular processes and alter epigenetic regulation, cause endocrine disruption, inhibit DNA damage repair mechanisms, and deregulate gene expression, among other adverse effects." | ( Arsenic-protein interactions as a mechanism of arsenic toxicity. León Del Río, A; Ostrosky-Wegman, P; Rodríguez-Dorantes, M; Salazar, AM; Vergara-Gerónimo, CA, 2021) | 0.62 |
| " Exposure to arsenic (particularly its inorganic form) through contaminated food and drinking water is an important public health burden worldwide, and is associated with increased risk of neurotoxicity, congenital anomalies, cancer, and adverse neurodevelopment in children." | ( Provision of folic acid for reducing arsenic toxicity in arsenic-exposed children and adults. Bae, S; Berry, RJ; Cassano, PA; Caudill, MA; Farinola, AF; Guetterman, HM; Kamynina, E; Stover, PJ, 2021) | 0.62 |
| " Silicon (Si) and arbuscular mycorrhizal (AM) fungi play significant roles in alleviating adverse effects of As stress." | ( Arbuscular mycorrhizae and silicon alleviate arsenic toxicity by enhancing soil nutrient availability, starch degradation and productivity in Cajanus cajan (L.) Millsp. Bhalla, S; Garg, N, 2021) | 0.62 |
| " Hence, polluted areas with the prevalence of multiple contaminants along with the highly toxic trace metals like As can impose a greater risk to the exposed organisms that may get further bio-magnified in the food chain." | ( Single toxicity of arsenic and combined trace metal exposure to a microalga of ecological and commercial interest: Diacronema lutheri. Das, S; Duong, G; Gevaert, F; Ouddane, B; Souissi, S, 2022) | 0.72 |
| " Moreover, the poorly known adverse effects of this element on eukaryotic microbes, as well as the As uptake and detoxification mechanisms developed by yeast and protists, are discussed." | ( Interactions with Arsenic: Mechanisms of Toxicity and Cellular Resistance in Eukaryotic Microorganisms. De Francisco, P; Díaz, S; Martín-González, A; Rodriguez-Martín, D, 2021) | 0.62 |
| "Arsenic (As), recognized as a toxic metalloid globally, has posed a serious threat to soil, plants and aquatic resources." | ( Exogenous triacontanol provides tolerance against arsenic-induced toxicity by scavenging ROS and improving morphology and physiological activities of Mentha arvensis L. Aftab, T; Khan, A; Masroor, M; Nabi, A; Naeem, M, 2022) | 0.72 |
| " Herein, we evaluated the phytotoxicity of arsenite [As(III)], including As accumulation and adverse physiological responses (e." | ( Arsenite phytotoxicity and metabolite redistribution in lettuce (Lactuca sativa L.). Dai, L; Li, J; Liu, X; Mu, L; Tang, X; Wang, Q; Wen, J; Weng, J, 2022) | 0.72 |
| " The increasing rate of global warming and anthropogenic activities have promptly exacerbated As levels in the agricultural soil, thereby causing adverse effects to crop genetic and phenotypic traits and rendering them vulnerable to other stresses." | ( Harnessing plant microbiome for mitigating arsenic toxicity in sustainable agriculture. Al-Mahmoudi, H; Ali, S; Bae, H; Mushtaq, M; Tyagi, A, 2022) | 0.72 |
| " The OVX-induced adverse effects were significantly reduced by E2 treatment." | ( Arsenic Induces Differential Neurotoxicity in Male, Female, and E2-Deficient Females: Comparative Effects on Hippocampal Neurons and Cognition in Adult Rats. Bandyopadhyay, S; Chattopadhyay, N; Garg, A; Gupta, K; Mandrah, K; Pandey, R; Roy, S; Shukla, P, 2022) | 0.72 |
| "Trivalent arsenic (As (III)) contamination in the marine environment can produce adverse effects in crustaceans." | ( Bioaccumulation of arsenic and immunotoxic effect in white shrimp (Penaeus vannamei) exposed to trivalent arsenic. Chen, BY; Chuang, HC; Huang, HT; Lee, PT; Liao, ZH; Nan, FH; Wang, PH; Wu, YS, 2022) | 0.72 |
| "The excessive arsenic (As) accumulation in plant tissues enforced toxic impacts on growth indices." | ( Attenuation mechanisms of arsenic induced toxicity and its accumulation in plants by engineered nanoparticles: A review. Ahmad, P; Alam, P; Bhat, JA; Senan, AM; Ulhassan, Z; Zhou, W, 2022) | 0.72 |
| "Arsenic metabolism enzymes can affect the toxic effects of arsenic." | ( Gender difference in arsenic biotransformation is an important metabolic basis for arsenic toxicity. Lai, Y; Muhetaer, M; Wu, J; Xia, R; Yang, M, 2022) | 0.72 |
| "5 times more toxic than arsenite." | ( Arsenate and arsenite differential toxicity in Tetrahymena thermophila. Amaro, F; de Francisco, P; Díaz, S; Gutiérrez, JC; Herráiz, M; Martín-González, A; Murciano, A; Rodríguez-Martín, D, 2022) | 0.72 |
| "Groundwater co-contamination with toxic pollutants like arsenic-fluoride or lead-fluoride is a serious threat for safe rice cultivation, since major stretches of land, involved in cultivation of this staple food crop are presently experiencing severe endemic pollution from these xenobiotic combinations." | ( Rhizofiltration of combined arsenic-fluoride or lead-fluoride polluted water using common aquatic plants and use of the 'clean' water for alleviating combined xenobiotic toxicity in a sensitive rice variety. Banerjee, A; Roychoudhury, A, 2022) | 0.72 |
| " The presence of heavy metals in too large amounts in products is a serious problem due to their allergenic and toxic effect." | ( Heavy metals in leathers, artificial leathers, and textiles in the context of quality and safety of use. Bielak, E; Marcinkowska, E, 2022) | 0.72 |
| " Several studies have indicated that numerous metals and metalloids can display severe adverse properties on the human reproductive system." | ( Heavy metal and metalloid - induced reproductive toxicity. Goutam Mukherjee, A; Ramesh Wanjari, U; Renu, K; Valsala Gopalakrishnan, A; Vellingiri, B, 2022) | 0.72 |
| " Surprisingly, synthetic organoarsenicals are extremely toxic molecules which created interest in their development as chemical warfare agents (CWAs) during World War I (WWI)." | ( Mechanistic understanding of the toxic effects of arsenic and warfare arsenicals on human health and environment. Athar, M; Gorbatyuk, MS; Khan, J; Muzaffar, S; Srivastava, R, 2023) | 0.91 |
| "Exposure to toxic metals alters host response and that leads to disease development." | ( Lysinibacillus sphaericus mediates stress responses and attenuates arsenic toxicity in Caenorhabditis elegans. Jass, J; Mandal, A; Mangu, JCK; Olsson, PE; Rai, N, 2022) | 0.72 |
| " Due to extreme energy requirements and high lipid levels, the brain is more susceptible to oxidative damage during aging especially under exposure to toxic elements such as arsenic." | ( Molecular mechanisms underlying ameliorative impact of melatonin against age-dependent chronic arsenic toxicity in rats' brains. Abdollahzade, N; Majidinia, M; Mihanfar, A, 2022) | 0.72 |
| " Initially, chelation therapy was used to metabolically eliminate arsenic by forming a complex, but adverse effects limited their pharmacological use." | ( Phytochemicals in the Management of Arsenic Toxicity. Flora, SJS; Khan, SS; Sharma, A, 2022) | 0.72 |
| "The toxic metalloid arsenic is known to cause liver and kidney injury in many humans and animals." | ( Hepatorenal Toxicity of Inorganic Arsenic in White Pekin Ducks and Its Amelioration by Using Ginger. Beura, CK; Jena, GR; Kumar, D; Mishra, SK; Naik, PK; Panda, B; Panda, SK; Patra, RC; Sethy, K; Swain, BK, 2023) | 0.91 |
| " toxic response." | ( Paleoecotoxicology: Developing methods to assess the toxicity of lake sediment records influenced by legacy gold mining. Blais, JM; Cheney, C; Pothier, M; Poulain, AJ; Sarma, SN; Thomas, PJ, 2022) | 0.72 |
| " Although chelation therapy is the most commonly used method for detoxifying As, it has several side effects resulting in various toxicities such as hepatotoxicity, neurotoxicity, and other adverse consequences." | ( Natural Dietary Compounds in the Treatment of Arsenic Toxicity. Bjørklund, G; Chasapis, CT; Chirumbolo, S; Lenchyk, L; Lysiuk, R; Oliynyk, P; Peana, M; Rahaman, MS; Shanaida, M, 2022) | 0.72 |
| "Currently little is known about the adsorption behaviors of metalloids on microplastics (MPs) and their complex toxic effects on aquatic plants." | ( The adsorption of arsenic on micro- and nano-plastics intensifies the toxic effect on submerged macrophytes. Gao, X; Li, X; Liu, X; Tang, N; Xing, W, 2022) | 0.72 |
| " To avoid or tolerate the toxic effects of HMs, plants have developed complicated defense mechanisms, including absorption and accumulation of HMs in cell organelles, immobilization by forming complexes with organic chelates, extraction by using numerous transporters, ion channels, signalling cascades, and transcription elements, among others." | ( State-of-the-art OMICS strategies against toxic effects of heavy metals in plants: A review. Cheng, H; Gul, S; Hussain, B; Li, Y; Nawaz, MF; Rahman, SU; Yasin, G, 2022) | 0.72 |
| " Arsenic is one of the most detrimental environmental toxins and its management with chelating agents remains a matter of concern due to associated adverse effects." | ( Flavonoids and stilbenoids as a promising arsenal for the management of chronic arsenic toxicity. Antoniv, O; Antonyak, H; Darmohray, R; Dub, N; Lenchyk, L; Lysiuk, R; Mishra, A; Oliinyk, P; Rathod, SSS; Tsal, O; Upyr, T, 2022) | 0.72 |
| " To attenuate such adverse effects and tone down As uptake by plants, the present study attempts to explore the role of K-humate (KH) in alleviation of As toxicity in rice." | ( Application of potassium humate to reduce arsenic bioavailability and toxicity in rice plants (Oryza sativa L.) during its course of germination and seedling growth. Acharya, K; Chowdhury, NR; Das, A; De, A; Joardar, M; Mridha, D; Ray, I; Roychowdhury, T; Sarkar, J, 2022) | 0.72 |
| "82) were low compared to other pinniped pups, indicating potential vulnerability of pups to the toxic effects of Hg." | ( Non-essential heavy metals and protective effects of selenium against mercury toxicity in endangered Australian sea lion (Neophoca cinerea) pups with hookworm disease. Gray, R; Lee, D; McQuilty, R; Taylor, S; Terkildsen, M; Wing-Simpson, A, 2022) | 0.72 |
| "Metals are common toxic environmental pollutants." | ( The Epitranscriptomic Mechanism of Metal Toxicity and Carcinogenesis. Wang, Z; Yang, C, 2022) | 0.72 |
| "Cosmetic and personal care products are considered an essential part of our daily care routine; hence, these products must be stable and safe for human use." | ( Quality and safety investigation of commonly used topical cosmetic preparations. Abdulwahab, A; Albukhary, N; Almukainzi, M; Alotaibi, L; El Mahdy, AM, 2022) | 0.72 |
| " Recently, several studies highlighted that Se treatment can effectively antagonize the toxic effects induced by arsenic." | ( Selenium Supplementation Protects Against Arsenic-Trioxide-Induced Cardiotoxicity Via Reducing Oxidative Stress and Inflammation Through Increasing NAD Li, WD; Mao, S; Yang, HB; Yuan, W, 2023) | 0.91 |
| "Arsenic (As) is a toxic substance that damages the human body through exposure to drinking water." | ( Effects of hyperbaric oxygen treatment on liver and kidney tissue in chronic arsenic toxicity. Aydeğer, C; Büyük, B; Eroğlu, HA; Makav, M; Öztopuz, Ö, ) | 0.13 |
| "Direct discharge of aquaculture wastewater may have toxic effects, due to the presence of heavy metals, antibiotics, and even resistant pathogens, but little attention has been given." | ( Toxic effects of long-term dual or single exposure to oxytetracycline and arsenic on Xenopus tropicalis living in duck wastewater. Li, X; Li, Y; Luan, T; Xu, Y; Zhao, J; Zheng, L, 2023) | 0.91 |
| " Arsenic (As) is an environmental pollutant with a major health concern due to its toxic effects on multiple body organs, including the brain." | ( Salix subserrata Bark Extract-Loaded Chitosan Nanoparticles Attenuate Neurotoxicity Induced by Sodium Arsenate in Rats in Relation with HPLC-PDA-ESI-MS/MS Profile. Bakr, AF; El-Shazly, AM; El-Shiekh, RA; Farrag, N; Hamdan, DI; Khalil, HMA; Mahmoud, MY; Tawfeek, N; Wink, M; Zaafar, D, 2022) | 0.72 |
| " We selected a typical calcareous soil area in western China that has been irrigated with wastewater for >50 years to explore safe use strategies for flax farmland contaminated by cadmium (Cd) and arsenic (As)." | ( Exploring the safe utilization strategy of calcareous agricultural land irrigated with wastewater for over 50 years. Hu, Y; Ma, S; Nan, Z; Wang, R; Wang, W; Zhang, Q, 2023) | 0.91 |
| "Arsenic (As) poisoning has proven to be a major threat worldwide because of its toxic effects on the human body." | ( Arsenic-induced toxicity and the ameliorative role of antioxidants and natural compounds. Dsouza, HS; Sajai, ST; Shiek, SS, 2023) | 0.91 |
| "Arsenic (As) and lead (Pb) are environmental pollutants found in common sites and linked to similar adverse health effects." | ( Joint Action Toxicity of Arsenic (As) and Lead (Pb) Mixtures in Developing Zebrafish. Freeman, JL; Kiper, K, 2022) | 0.72 |
| " Safe and sustainable water supply, particularly in the northern arid basins, demands a quantitative prediction of the high variability of I distribution over hydrogeological timescales." | ( Spatiotemporal Variability of Groundwater Iodine in the Northern Arid Basins: Significance for Safe Water Supply. Li, J; Pi, K; Qian, K; Van Cappellen, P; Wang, Y; Xie, X; Zhang, D, 2023) | 0.91 |
| " The Integrated Biomarker Response (IBR) index was used to integrate the multi-biomarker responses, and the results also exhibited enhanced toxic effects in combined treatments of inorganic arsenic and PFOA." | ( How do different arsenic species affect the joint toxicity of perfluorooctanoic acid and arsenic to earthworm Eisenia fetida: A multi-biomarker approach. Cao, X; Cui, X; Cui, Z; Li, C; Qi, F; Wang, N; Wang, Z; Xue, W; Zhang, Z, 2023) | 0.91 |
| " As both Cr(III) and As(V) are less toxic than their corresponding counterparts Cr(VI) and As(III), different redox interactions between BCs and Cr/As and release profiles between BCs and Cr/As together lead to reduced combined cytotoxicity of BP-BC-Cr(VI) and BP-BC-As(III)." | ( Chemical speciation determines combined cytotoxicity: Examples of biochar and arsenic/chromium. Liu, J; Liu, W; Mo, Y; Wen, Y; Yan, B; Yan, X; Zhou, H, 2023) | 0.91 |
| "Sustainable remediation of arsenic-fluoride from rice fields through efficient bio-extraction is the need of the hour, since these toxicants severely challenge safe cultivation of rice and food biosafety." | ( Bio-priming with a Novel Plant Growth-Promoting Acinetobacter indicus Strain Alleviates Arsenic-Fluoride Co-toxicity in Rice by Modulating the Physiome and Micronutrient Homeostasis. Banerjee, A; Roychoudhury, A, 2023) | 0.91 |
| "Arsenic is a notorious metalloid that exists in the earth's crust and is considered toxic for humans and the environment." | ( The protective effect of natural or chemical compounds against arsenic-induced neurotoxicity: Cellular and molecular mechanisms. Barangi, S; Hosseinzadeh, H; Mehri, S; Shayan, M, 2023) | 0.91 |
| " Toxic metal exposure, especially cadmium, arsenic, and lead, causes oxidative damages, mitochondrial dysfunction, and genetic and epigenetic modifications." | ( Protective potential of thymoquinone against cadmium, arsenic, and lead toxicity: A short review with emphasis on oxidative pathways. Ghasemi, F; Nili-Ahmadabadi, A; Nili-Ahmadabadi, M; Omidifar, N, 2023) | 0.91 |
| " To obtain the linkage between investigated toxic mixture and thyroid diseases (TDs), the Comparative Toxicogenomics Database (CTD) was used, while gene ontology (GO) enrichment analysis was performed by ToppGeneSuite portal." | ( In silico assessment of mixture toxicity mechanisms involved in the pathogenesis of thyroid diseases: The combination of toxic metal(oid)s and decabrominated diphenyl ether. Antonijević Miljaković, E; Antonijević, B; Baralić, K; Buha Đorđević, A; Bulat, Z; Ćurčić, M; Radović, B; Stojilković, N; Vukelić Javorac, D; Đukić-Ćosić, D, 2023) | 0.91 |
| "NR induced moderate toxic effects at high dose but can be considered safe at therapeutic doses." | ( Assessment of sub-chronic oral toxicity of Nityanand Rasa: An ayurvedic herbo-metallic formulation. Bajad, SM; Kshirsagar, SR; Kumar, MJM; Kumari, M; Kumari, SI; Saxena, S, 2023) | 0.91 |
| "The community-led SHWS program conducted a theory-driven approach for intervention development and evaluation that allowed for behavioral determinants to be identified that were associated with the use of arsenic safe water and changing one's arsenic filter cartridge." | ( Behavioral determinants of arsenic-safe water use among Great Plains Indian Nation private well users: results from the Community-Led Strong Heart Water Study Arsenic Mitigation Program. Aurand, D; Bear Robe, L; Best, LG; Black Bear, A; Cuny, C; Endres, K; George, CM; Gross, M; Harvey, D; Moulton, LH; Navas-Acien, A; O'Leary, M; Perin, J; Powers, M; Red Cloud, R; Richards, F; Ristau, S; Rule, A; Schwab, K; Skinner, L; Thomas, ED; Yracheta, J; Zacher, T, 2023) | 0.91 |
| "Soil contamination with toxic heavy metals (such as arsenic (As)) is becoming a serious global problem due to rapid development of social economy, although the use of silicon (Si) and sodium hydrosulfide (NaHS) has been found effective in enhancing plant tolerance against biotic and abiotic stresses including the As toxicity." | ( Application of silicon and sodium hydrosulfide alleviates arsenic toxicity by regulating the physio-biochemical and molecular mechanisms of Zea mays. Alatawi, A; Ali, S; Alshegaihi, RM; Asghar, MA; Elsharkawy, MM; Fahad, S; Javed, S; Marc, RA; Mfarrej, MFB; Mumtaz, S; Yasin, G, 2023) | 0.91 |
| " The results of this investigation support that HS should be considered when safe limits for As and Co are defined." | ( Impact of aquatic humic substances on speciation and toxicity of arsenic and cobalt to Ceriodaphnia dubia. Domingues, MT; Fracácio, R; Gontijo, ESJ; Rosa, AH; Watanabe, CH, 2023) | 0.91 |
| "Arsenic (As) is a toxic element, and long-term exposure to As can cause neurotoxicity." | ( Proteomic Study on the Mechanism of Arsenic Neurotoxicity in the Rat Cerebral Cortex and the Protective Mechanism of Dictyophora Polysaccharides against Arsenic Neurotoxicity. Cao, X; Chen, X; Hu, T; Liang, Y; Lin, J; Luo, P; Shen, L; Tang, X; Wang, Y; Yan, X; Yang, H; Zhang, H; Zhang, J; Zhang, X; Zhuang, H, 2023) | 0.91 |
| " However, the accurate health risks and adverse effects of As on humans were largely unknown." | ( Refining health risk assessment of arsenic in wild edible boletus from typical high geochemical background areas: The role of As species, bioavailability, and enterotoxicity. Chen, Z; Li, M; Ma, LQ; Mu, Y; Xiang, P; Xie, Y; Xiong, Q; Zhang, M, 2023) | 0.91 |
| " Additionally, the co-presence of microplastics and arsenic can cause synergistic, antagonistic, or potentiating toxic impacts on plants." | ( Effects of microplastics and arsenic on plants: Interactions, toxicity and environmental implications. Bhattacharya, S; Dey, A; Dey, S; Gupta, K; Ivy, N; Sharma, P, 2023) | 0.91 |
| " In conclusion, the obtained results of the present study have clinical significance and indicate that apigenin is a promising candidate for shielding the nervous system from toxic effects caused by arsenic." | ( The protective effect of apigenin against inorganic arsenic salt-induced toxicity in PC12 cells. Almeer, R; Alyami, NM, 2023) | 0.91 |
| " Both elements are toxic to cells and organisms, and exposure is associated with several pathological conditions including cancer and neurodegenerative disorders." | ( Mechanisms of genotoxicity and proteotoxicity induced by the metalloids arsenic and antimony. Litwin, I; Rodrigues, JI; Tamás, MJ; Wysocki, R, 2023) | 0.91 |
| " ATO did not increase the risk of common adverse events compared to supportive therapy [(OR = 0." | ( The efficacy and adverse events of arsenic trioxide for the patients with myelodysplastic syndrome: a systematic review and component network meta-analysis. Huang, X; Liu, R; Liu, Y; Yang, H; Zou, X, 2023) | 0.91 |
| " Exposures to these metals are associated with impaired neuronal functions and adverse effects on neurodevelopment in children." | ( Identification of novel NRF2-dependent genes as regulators of lead and arsenic toxicity in neural progenitor cells. Azzara, D; Boomhower, SR; Cohen, ED; Diwadkar, AR; Himes, BE; Lu, Q; O'Reilly, MA; Park, HR, 2024) | 1.44 |
A physiologically-based pharmacokinetic (PBPK) model was developed to estimate levels of arsenic and its metabolites in human tissues and urine after oral exposure to arsenate, arsenite or organoarsenical pesticides. The pharmacokinetics profiles of the pharmacologically active arsenical species, arsenious acid (As(III), were evaluated.
To study the clinical outcome and treatment cost of homoharringtonine (HHT) in combination with all-trans retinoic acid (ATRA) and arsenic trioxide (AS2O3) for newly diagnosed with patients acute promyelocytic leukemia (APL) To investigate the antitumor effect of arsenic Trioxide (ATO) combined with itraconazole (ITRA) on human multiple myeloma NCI-H929 cells.
Arsenic-induced reduction in vasomotion frequency of the isolated aortic rings is associated with a decreased bioavailability of NO. Contrary to arsenic, phosphorus bioavailability was shown to decrease in the arsenic/iron flux maxima. This study demonstrates the dual importance of organic matter (OM), in terms of enhancing arsenic release from soils.
| Excerpt | Reference | Relevance |
|---|---|---|
| " It therefore appears that drug bioavailability is altered or drug biotransformation occurs during the in vivo test." | ( In vivo and in vitro sensitivity of Trypanosoma evansi and T. equiperdum to diminazene, suramin, MelCy, quinapyramine and isometamidium. Baltz, T; Giroud, C; Zhang, ZQ, 1991) | 0.28 |
| " We also undertook a separate bioavailability study using Se-methylselenocysteine, dimethyl selenoxide, and trimethylselenonium as the starting compounds for delivering selenium with one, two, or three methyl groups, and measured the ability of these compounds to restore glutathione peroxidase activity in selenium-depleted animals." | ( Chemical form of selenium, critical metabolites, and cancer prevention. Budnick, RM; Ganther, HE; Hayes, C; Ip, C, 1991) | 0.28 |
| " It also demonstrates the distinction between airborne arsenic and the bioavailability of arsenic, and the importance of this distinction for risk assessment." | ( Exposure to arsenic and respiratory cancer. A reanalysis. Enterline, PE; Henderson, VL; Marsh, GM, 1987) | 0.27 |
| " The reduction of SeO2 by SO2 to Se0 results in less bioavailability in the food cycle." | ( What do losses in selenium and arsenic bioavailability signify for health? Frost, DV, 1983) | 0.27 |
| " As a means of estimating potential element bioavailability at the site, the modeled body burdens were compared with measured element concentrations in herbivore tissues." | ( Bioavailability of metals and arsenic to small mammals at a mining waste-contaminated wetland. Blanchet, RJ; Linder, G; Pascoe, GA, 1994) | 0.29 |
| " These standards are based on the assumption that in humans the bioavailability of arsenic from ingested soil is equal to that from an aqueous solution." | ( Bioavailability of inorganic arsenic from bog ore-containing soil in the dog. de Boer, JL; Groen, K; Kliest, JJ; Timmerman, A; Vaessen, HA; van Ooik, T; Vlug, RF, 1994) | 0.29 |
| " By extrapolation from animal studies, the daily dietary intakes of these elements needed to prevent deficiency or to provide beneficial action in humans are arsenic, 12-25 micrograms; nickel, 100 micrograms; silicon, 2-5 mg (based on 10% bioavailability in natural diets) and vanadium, 10 micrograms." | ( Deliberations and evaluations of the approaches, endpoints and paradigms for dietary recommendations of the other trace elements. Seaborn, CD; Uthus, EO, 1996) | 0.29 |
| " Mean absolute percentage bioavailability values based on urinary excretion data were 68, 19, and 14% for the gavage, house dust, and soil treatments, respectively, after normalization of the intravenous As recovery data to 100%." | ( Bioavailability of arsenic in soil and house dust impacted by smelter activities following oral administration in cynomolgus monkeys. Bergstrom, PD; Davis, AO; Dill, JA; Freeman, GB; Lapin, CA; Liao, SC; Ruby, MV; Schoof, RA, 1995) | 0.29 |
| " Comparisons with previously published studies of exposure to arsenic trioxide vapors and dusts in copper smelters suggest that bioavailability of arsenic from airborne coal fly ash (as indicated by urinary excretion) is about one-third that seen in smelters and similar settings." | ( Airborne arsenic and urinary excretion of arsenic metabolites during boiler cleaning operations in a Slovak coal-fired power plant. Fabianova, E; Hicks, JB; Yager, JW, 1997) | 0.3 |
| " Site-specific risk assessments for arsenic in soil can be improved by characterizing the form of arsenic in soil, by conducting animal feeding or in vitro bioavailability studies using site soils, and by conducting studies to evaluate the relationship between urinary arsenic and soil arsenic levels." | ( Issues in setting health-based cleanup levels for arsenic in soil. Beck, BD; Bergstrom, PD; Boardman, PD; Bowers, TS; Keating, JL; Valberg, PA, 1997) | 0.3 |
| " The importance of using permeability coefficients rather than n-octanol/water partition coefficients in determining bioavailability and bioaccumulation of environmentally sensitive compounds is also discussed." | ( Vesicular membrane permeability of monomethylarsonic and dimethylarsinic acids. Cullen, WR; Herring, FG; Males, RG; Nelson, JC; Phillips, PS, 1998) | 0.3 |
| " Bioavailability of toxins also presents a problem because the data on bioavailability are sparse and seldom as high as the default of 100% bioavailability commonly used in risk assessment." | ( Environmental poisoning: presentation and management. Lewis, RJ; Moore, MR; Ng, JC, 1998) | 0.3 |
| " This study investigates the contamination and the uptake of arsenic by plants because little is known about the bioavailability and metabolism of sternutators and their constituents." | ( Risk assessment of a former military base contaminated with organoarsenic-based warfare agents: uptake of arsenic by terrestrial plants. König, P; Kramer, A; Müller, G; Pitten, FA; Schmidt, D; Thurow, K, 1999) | 0.3 |
| "Understanding metal bioavailability of plants in soils requires, apart from physiological processes and symbiosis with arbuscular mycorrhizal fungi, the consideration of the chemical availability in the soil solution (the intensity of the toxic exposure) and the soil's capacity to supply the metal (capacity)." | ( Quantification of metal bioavailability for lettuce (Lactuca sativa L.) in field soils. Baerselman, R; de Groot, A; Jager, T; Leenders, D; Peijnenburg, W; Posthuma, L; Van Veen, R, 2000) | 0.31 |
| "The oral bioavailability of soil contaminants is measured using in vitro or in vivo techniques." | ( Oral bioavailability of lead and arsenic from a NIST standard reference soil material. Buckley, BT; Ellickson, KM; Gallo, MA; Lioy, PJ; Meeker, RJ, 2001) | 0.31 |
| " Bioavailability of Cu in the soils from one uncontaminated and two contaminated sites and in the uncontaminated soil treated with CuCl2 was determined using sequential extraction." | ( Resistance to copper toxicity in populations of the earthworms Lumbricus rubellus and Dendrodrilus rubidus from contaminated mine wastes. Langdon, CJ; Meharg, AA; Piearce, TG; Semple, KT, 2001) | 0.31 |
| " Analyses of As in pyloric caeca, intestine, liver and scales are recommended to evaluate the bioavailability of As to freshwater fish in environmental monitoring programs." | ( Accumulation and distribution of dietary arsenic in lake whitefish (Coregonus clupeaformis). Klaverkamp, JF; Pedlar, RM, 2002) | 0.31 |
| " Factors that influence adsorption capacity of soils influence the bioavailability and subsequent mobility of As in soils." | ( Chemistry of inorganic arsenic in soils: II. Effect of phosphorus, sodium, and calcium on arsenic sorption. Alston, AM; Naidu, R; Smith, E, ) | 0.13 |
| " Although these metals are tightly bound to the wood fibers and are not released under most conditions of use, we examined the bioavailability of metals in CCA pressure-treated wood dust in vitro." | ( In vitro bioavailability of heavy metals in pressure-treated wood dust. Butala, JH; Gordon, T; Li, P; Rossman, TG; Spanier, J, 2002) | 0.31 |
| " This has led to increased interest in including measurements of arsenic relative bioavailability from soils in the calculation of risks to human health posed by arsenic-contaminated sites." | ( Measurement of arsenic bioavailability in soil using a primate model. Bergeron, RJ; Munson, JW; Roberts, SM; Vinson, JR; Weimar, WR, 2002) | 0.31 |
| " Rhizosphere interactions are deemed to play a key role in controlling bioavailability to crop plants and for a better understanding and improvement of phytoremediation technologies." | ( Arsenic transformations in the soil-rhizosphere-plant system: fundamentals and potential application to phytoremediation. Fitz, WJ; Wenzel, WW, 2002) | 0.31 |
| " None the less, the bioavailability of As through food can be different than via drinking water." | ( Arsenic levels in cooked food and assessment of adult dietary intake of arsenic in the Region Lagunera, Mexico. Cebrian, ME; Del Razo, LM; Garcia-Salcedo, J; Garcia-Vargas, GG; Hernandez, MC; Rivera, M; Sanmiguel, MF, 2002) | 0.31 |
| "5% the in vivo bioavailability of As in nine contaminated soils previously used in swine dosing trials." | ( Adsorption, sequestration, and bioaccessibility of As(V) in soils. Barnett, MO; Basta, NT; Casteel, SW; Jardine, PM; Yang, JK, 2002) | 0.31 |
| " We therefore developed an oral formulation, administered it to patients and set out to assess the resulting systemic bioavailability of arsenic." | ( Systemic availability of arsenic from oral arsenic-trioxide used to treat patients with hematological malignancies. Au, WY; Kou, M; Kumana, CR; Kwong, YL; Lam, CW; Lee, NS; Mak, RW, 2002) | 0.31 |
| " Systemic bioavailability was inferred from the area under the arsenic level versus time curve (AUC) using the trapezoidal rule." | ( Systemic availability of arsenic from oral arsenic-trioxide used to treat patients with hematological malignancies. Au, WY; Kou, M; Kumana, CR; Kwong, YL; Lam, CW; Lee, NS; Mak, RW, 2002) | 0.31 |
| " dosing, our oral As2O3 formulation was more convenient and cost effective, and the ensuing systemic bioavailability of arsenic appeared similar." | ( Systemic availability of arsenic from oral arsenic-trioxide used to treat patients with hematological malignancies. Au, WY; Kou, M; Kumana, CR; Kwong, YL; Lam, CW; Lee, NS; Mak, RW, 2002) | 0.31 |
| " Over a wide range of AVS concentrations and molar [As]/[AVS] ratios, acid extraction of arsenic from sulfide-bearing sediments will give biased results that overestimate the stability or underestimate the bioavailability of sediment-bound arsenic." | ( Use of hydrochloric acid for determinining solid-phase arsenic partitioning in sulfidic sediments. Ford, RG; Wilkin, RT, 2002) | 0.31 |
| " According to the results of this study, a significant positive correlation was found between the concentration of total water-soluble As and the bioavailability of As." | ( Analysis of arsenic bioavailability in contaminated soils. Häggblom, MM; Turpeinen, R; Virta, M, 2003) | 0.32 |
| " To understand the bioavailability of arsenic in this environment and its possible entry into human food chain, speciation studies of arsenic was carried out and the results are presented in this paper." | ( Risk assessment and pathway study of arsenic in industrially contaminated sites of Hyderabad: a case study. Anjaneyulu, Y; Balaram, V; Chandra Sekhar, K; Chary, NS; Kamala, CT; Venkateswara Rao, J, 2003) | 0.32 |
| " Hence, bioavailability of As(V) is low in this environment, despite the substantial As flux." | ( Mobilisation and bioavailability of arsenic around mesothermal gold deposits in a semiarid environment, Otago, New Zealand. Craw, D; Pacheco, L, 2002) | 0.31 |
| " The effects on As bioavailability were assessed using a range of vegetable crops grown in the field." | ( Field trials to assess the uptake of arsenic by vegetables from contaminated soils and soil remediation with iron oxides. Alloway, BJ; Bochereau, FJ; Lepp, NW; Penny, C; Singh, B; Warren, GP, 2003) | 0.32 |
| " While the toxicity of arsenic to plants and animals is well recognized, the geochemical and biological transformations that alter its bioavailability in the environment are multifaceted and remain poorly understood." | ( Biogeochemical transformations of arsenic in circumneutral freshwater sediments. Moore, JN; Nicholas, DR; Palace, V; Ramamoorthy, S; Rosenzweig, RF; Spring, S, 2003) | 0.32 |
| " The toxicity of arsenic is dependent to a large extent on its bioavailability or its ability to be liberated from various matrices and be internalized in the target organs of the host." | ( Case studies of the impact of understanding bioavailability: arsenic. Caussy, D, 2003) | 0.32 |
| " While animal studies are needed to verify the in vitro results, preliminary data indicate that this modified method may be able to improve site-specific bioavailability predictions in arsenic-contaminated soils." | ( A modified in-vitro method to assess bioavailable arsenic in pesticide-applied soils. Datta, R; Sarkar, D, 2003) | 0.32 |
| " and the influence of PO(4) (3-) on As bioavailability and uptake were tested in batch culture." | ( Toxicity of arsenic species to Lemna gibba L. and the influence of phosphate on arsenic bioavailability. Dudel, EG; Kosterin, PV; Lyubun, YV; Mkandawire, M, 2004) | 0.32 |
| " Studies in the 1970s and the 1980s of metal bioavailability and impacts of metals and metalloids were driven by the process of abatement of lead in the environment." | ( A commentary on the impacts of metals and metalloids in the environment upon the metabolism of drugs and chemicals. Moore, MR, 2004) | 0.32 |
| "Factors that can affect As and Se adsorption by soils influence the bioavailability and mobility of these elements in the subsurface." | ( Geochemistry of inorganic arsenic and selenium in a tropical soil: effect of reaction time, pH, and competitive anions on arsenic and selenium adsorption. Goh, KH; Lim, TT, 2004) | 0.32 |
| " Additionally, the results show that arsenic is poorly absorbed from CCA-treated wood residues (i." | ( In vivo percutaneous absorption of arsenic from water and CCA-treated wood residue. Barbadillo, S; Holm, SE; Hui, X; Lowney, YW; Maibach, HI; Ruby, MV; Schoof, RA; Wester, RC, 2004) | 0.32 |
| "The bioavailability and transport of particle-reactive pollutants are influenced by their partitioning between dissolved and particulate phases." | ( Particulate arsenic and iron during anoxia in a eutrophic, urban lake. Hemond, HF; Senn, DB, 2004) | 0.32 |
| "Asian clam Corbicula fluminea, the amphipod Dikerogammarus villosus and the macrophyte Nuphar lutea were tested for investigating spatial and temporal variability in the bioavailability of tin and arsenic in the River Lippe, Germany." | ( Biomonitoring of tin and arsenic in different compartments of a limnic ecosystem with emphasis on Corbicula fluminea and Dikerogammarus villosus. Emons, H; Ettwig, KF; Sebesvari, Z, 2005) | 0.33 |
| " The mobility and bioavailability of arsenic in soil is mostly controlled by adsorption and desorption reactions." | ( Desorption kinetics of arsenate from kaolinite as influenced by pH. Hinz, C; Quaghebeur, M; Rate, A; Rengel, Z, ) | 0.13 |
| "Although it is now commonly accepted that toxicity and bioavailability varies with As species, extensive research has been carried out on biological and environmental samples to assess toxicity and risk associated with As exposure based on total concentrations that may be in error." | ( Arsenic speciation and toxicity in biological systems. Akter, KF; Davey, DE; Naidu, R; Owens, G, 2005) | 0.33 |
| " The results demonstrate that those elements with a high degree of pyritization may be released into the water through oxidation of the metal sulphides that they form when in suspension in oxic sea water, with the subsequent risk of increased bioavailability to benthic fauna." | ( Trace elements in biodeposits and sediments from mussel culture in the Ria de Arousa (Galicia, NW Spain). Calvo de Anta, RM; Macías, F; Otero, XL; Vidal-Torrado, P, 2005) | 0.33 |
| " The addition of lime and the organic amendments achieved higher plant biomass production, although effects concerning metal bioavailability and accumulation were masked somewhat by pH variability with time and between and within plots." | ( Uptake of heavy metals and As by Brassica juncea grown in a contaminated soil in Aznalcóllar (Spain): the effect of soil amendments. Bernal, MP; Clemente, R; Walker, DJ, 2005) | 0.33 |
| "A laboratory incubation study was conducted to estimate geochemical speciation and in vitro bioavailability of arsenic as a function of soil properties." | ( Fate and bioavailability of arsenic in organo-arsenical pesticide-applied soils. Part-I: incubation study. Datta, R; Sarkar, D; Sharma, S, 2005) | 0.33 |
| " Our results demonstrate that the nonpathogenic bacterial biosensor developed in the present study is useful and applicable in determining the bioavailability of arsenic with high sensitivity in contaminated groundwater samples, and they suggest a potential for its inexpensive application in field-ready tests." | ( Development and testing of a green fluorescent protein-based bacterial biosensor for measuring bioavailable arsenic in contaminated groundwater samples. Liao, VH; Ou, KL, 2005) | 0.33 |
| " Arsenic (As) dosage in pore water shows that a change in its bioavailability occurs that may explain the surprising toxicity results." | ( Unexpected reduction in reproduction of Collembola exposed to an arsenic-contaminated soil. Cazes, L; Crouau, Y, 2005) | 0.33 |
| " Among the nine chelating agents used, it was noted that 20 mmol NTA could maximize As and Zn bioavailability, while 20 mmol HEIDA could maximize Cu bioavailability in the soil solution." | ( Enhanced uptake of As, Zn, and Cu by Vetiveria zizanioides and Zea mays using chelating agents. Chiu, KK; Wong, MH; Ye, ZH, 2005) | 0.33 |
| " Although the excised carcass contains about half of the TBB, its importance in food-chain transfer of arsenic to predators may depend on the bioavailability of arsenic sequestered in fur." | ( The distribution of arsenic in the body tissues of wood mice and bank voles. Erry, BV; Macnair, MR; Meharg, AA; Shore, RF, 2005) | 0.33 |
| "Adsorption-desorption of arsenic is the primary factor that impacts the bioavailability and mobility of arsenic in soils." | ( Kinetics of arsenate adsorption-desorption in soils. Selim, HM; Zhang, H, 2005) | 0.33 |
| "At As-contaminated sites, where the ingestion of soil by children is typically the critical human-health exposure pathway, information on the bioavailability of soil-bound As is often limited." | ( Adsorption, oxidation, and bioaccessibility of As(III) in soils. Barnett, MO; Fendorf, SE; Jardine, PM; Yang, JK; Zhuang, J, 2005) | 0.33 |
| " A Pearson correlation matrix suggested that pH and mineralogical composition were important factors controlling metal bioavailability from materials in abandoned mining sites." | ( Lead, cadmium and arsenic bioavailability in the abandoned mine site of Cabezo Rajao (Murcia, SE Spain). Marimón, J; Martínez-Sánchez, MJ; Navarro, MC; Pérez-Sirvent, C; Vidal, J, 2006) | 0.33 |
| " The authors conducted a laboratory incubation study to analyze the in vitro bioavailability of arsenic in soils as a function of soil properties." | ( Human health risks from arsenic in soils: does one model fit all? Datta, R; Sarkar, D, 2004) | 0.32 |
| " To evaluate the bioavailability of heavy metals in two soils from Jales mine surroundings, bioassays with the plants Brassica rapa (RCBr) and Avena sativa were performed." | ( Toxicity assessment of two soils from Jales mine (Portugal) using plants: growth and biochemical parameters. Costa, A; Loureiro, S; Monteiro, M; Nogueira, AJ; Pinto, G; Santos, C; Soares, AM, 2006) | 0.33 |
| " This finding links the extensive chemical characterization and bioavailability testing that has been done previously on the brush-removed residue to a material that is derived from human skin contact with CCA-treated wood." | ( Chemical speciation and bioaccessibility of arsenic and chromium in chromated copper arsenate-treated wood and soils. Holm, SE; Lowney, YW; Nico, PS; Ruby, MV, 2006) | 0.33 |
| " Their body concentrations should be good indicators of bioavailability and useful for environmental assessment." | ( Saturation models of arsenic, cobalt, chromium and manganese bioaccumulation by Hyalella azteca. Borgmann, U; Dixon, DG; Norwood, WP, 2006) | 0.33 |
| " This study evaluated the efficiency of Fe(0) to reduce the mobility and bioavailability of Cr, Cu, As and Zn in a chromated copper arsenate (CCA)-contaminated soil using chemical, biochemical and biotoxicity tests." | ( Assessment of zerovalent iron for stabilization of chromium, copper, and arsenic in soil. Kumpiene, J; Lagerkvist, A; Maurice, C; Mench, M; Ore, S; Renella, G, 2006) | 0.33 |
| " Because As bioavailability is a function of soil speciation, using total soil arsenic values potentially overestimates human health risk, thereby increasing site cleanup expenses." | ( Consideration of soil properties in assessment of human health risk from exposure to arsenic-enriched soils. Datta, R; Sarkar, D, 2005) | 0.33 |
| " Toxicity estimates are based on bioavailability causing risk of adverse health effects on humans." | ( Human risk assessment for heavy metals and as contamination in the abandoned metal mine areas, Korea. Kim, JY; Kim, KW; Lee, BT; Lee, JS; Lee, SW, 2006) | 0.33 |
| " Moreover, two operational defined extraction procedures commonly used in soil and sediment studies (first and second steps of BCR procedure and DTPA extraction protocol) were applied in the different mining wastes in order to study Pb and Zn mobility and likely bioavailability to Betula pendula growing on the same mining spoils, which presents lead and zinc contents in leaves over ten times background values." | ( Assessment of metal availability to vegetation (Betula pendula) in Pb-Zn ore concentrate residues with different features. Carvalho, ML; Hidalgo, M; Marguí, E; Queralt, I, 2007) | 0.34 |
| " The development of new generations of orally bioavailable inorganic, as well as new organic, arsenic compounds with improved toxicity profiles may bolster the therapeutic application of arsenic derivatives in hematologic malignancies such as leukemia, multiple myeloma and myelodysplastic syndromes." | ( Arsenic derivatives in hematologic malignancies: a role beyond acute promyelocytic leukemia? Beran, M; Freireich, E; Giles, F; Kantarjian, H; Perez, N; Quintás-Cardama, A; Ravandi-Kashani, F; Verstovsek, S, 2006) | 0.33 |
| " However, its poor water-solubility unfortunately results in poor bioavailability and hampers it from being studied and used for possible clinical application." | ( Evaluation of the in vitro activity and in vivo bioavailability of realgar nanoparticles prepared by cryo-grinding. Ho, PC; Wu, JZ, 2006) | 0.33 |
| " Therefore, a strong need exists to provide accurate data on oral relative bioavailability (RBA) of arsenic (in vivo or in vitro) in field-collected CCA-contaminated soils." | ( In vitro gastrointestinal bioavailability of arsenic in soils collected near CCA-treated utility poles. Pouschat, P; Zagury, GJ, 2006) | 0.33 |
| " Interestingly, about 20-fold more Hg and 4-fold more As was available to non-immobilised sensor bacteria indicating the importance of direct cell contact (possible only for non-immobilised cells) for enhanced bioavailability of these metals in solid samples." | ( Fibre-optic bacterial biosensors and their application for the analysis of bioavailable Hg and As in soils and sediments from Aznalcollar mining area in Spain. Green, T; Ivask, A; Kahru, A; Marks, R; Mor, A; Polyak, B; Virta, M, 2007) | 0.34 |
| " The distinction between "free" As and colloid-bound/complexed As in soil solution is important for understanding the mobility and bioavailability of As in the environment." | ( Interactions of arsenic and the dissolved substances derived from turf soils. Cai, Y; Chen, Z; Cisar, JL; Snyder, GH; Solo-Gabriele, H, 2006) | 0.33 |
| " Tungsten appears to be relatively immobile when subjected to sequential extraction but increased bioavailability is indicated when single stage extraction using EDTA is employed." | ( Bio-availability of tungsten in the vicinity of an abandoned mine in the English Lake District and some potential health implications. Pyatt, FB; Wilson, B, 2006) | 0.33 |
| " A static incubation study was conducted to estimate soil speciation and in-vitro bioavailability (i." | ( Arsenic biogeochemistry and human health risk assessment in organo-arsenical pesticide-applied acidic and alkaline soils: an incubation study. Datta, R; Sand, K; Sarkar, D; Sharma, S, 2006) | 0.33 |
| "A number of studies have found that gastrointestinal absorption of arsenic from soil is limited, indicating that a relative oral bioavailability (RBA) adjustment is warranted when calculating risks from exposure to arsenic-contaminated soil." | ( Relative oral bioavailability of arsenic from contaminated soils measured in the cynomolgus monkey. Lowney, YW; Munson, JW; Roberts, SM; Ruby, MV, 2007) | 0.34 |
| " They were subject to an As sequential fractionation scheme and two in-vitro tests (IVGS and IVGIA) to simulate soil As bioavailability in the human gastrointestinal system." | ( Effect of soil properties on arsenic fractionation and bioaccessibility in cattle and sheep dipping vat sites. Datta, R; Makris, KC; Parra-Noonan, MT; Sarkar, D, 2007) | 0.34 |
| " The mobility and bioavailability of these arsenic species in the environment are strongly influenced by their interactions with mineral surface, especially iron and aluminum oxides." | ( Effect of replacing a hydroxyl group with a methyl group on arsenic (V) species adsorption on goethite (alpha-FeOOH). Pehkonen, SO; Stanforth, RS; Zhang, JS, 2007) | 0.34 |
| " In order to estimate the human bioavailability quotients for As and heavy metals, 12 urban roadside soil samples were collected and analyzed for As, Pb, Cu, Zn, Ni, Co, and Cr using Simple Bioavailability Extraction Test (SBET)." | ( Leaching characteristics of arsenic and heavy metals in urban roadside soils using a simple bioavailability extraction test. Chen, YK; Qin, Y; Wang, XS, 2007) | 0.34 |
| " Soil physical conditions have to be taken into account when assessing the bioavailability of the contaminant As or the essential nutrient Se." | ( Effects of soil compaction and irrigation on the concentrations of selenium and arsenic in wheat grains. Clark, LJ; Gray, CW; Lopez-Bellido, FJ; McGrath, SP; Whalley, WR; Zhao, FJ, 2007) | 0.34 |
| "Millions of people worldwide consume arsenic-contaminated rice; however, little is known about the uptake and bioavailability of arsenic species after arsenic-contaminated rice ingestion." | ( In vivo assessment of arsenic bioavailability in rice and its significance for human health risk assessment. Juhasz, AL; Kuchel, T; Naidu, R; Rees, M; Rofe, A; Sansom, L; Smith, E; Weber, J, 2006) | 0.33 |
| "In this study, we assessed arsenic speciation in greenhouse-grown and supermarket-bought rice, and determined arsenic bioavailability in cooked rice using an in vivo swine model." | ( In vivo assessment of arsenic bioavailability in rice and its significance for human health risk assessment. Juhasz, AL; Kuchel, T; Naidu, R; Rees, M; Rofe, A; Sansom, L; Smith, E; Weber, J, 2006) | 0.33 |
| " Because of the low absolute bioavailability of dimethylarsinic acid and the high proportion of dimethylarsinic acid in greenhouse-grown rice, only 33 +/- 3% (mean +/- SD) of the total rice-bound arsenic was bioavailable." | ( In vivo assessment of arsenic bioavailability in rice and its significance for human health risk assessment. Juhasz, AL; Kuchel, T; Naidu, R; Rees, M; Rofe, A; Sansom, L; Smith, E; Weber, J, 2006) | 0.33 |
| "These results indicate that arsenic bioavailability in rice is highly dependent on arsenic speciation, which in turn can vary depending on rice cultivar, arsenic in irrigation water, and the presence and nature of arsenic speciation in cooking water." | ( In vivo assessment of arsenic bioavailability in rice and its significance for human health risk assessment. Juhasz, AL; Kuchel, T; Naidu, R; Rees, M; Rofe, A; Sansom, L; Smith, E; Weber, J, 2006) | 0.33 |
| " Contaminant immobilizing amendments decrease trace element leaching and their bioavailability by inducing various sorption processes: adsorption to mineral surfaces, formation of stable complexes with organic ligands, surface precipitation and ion exchange." | ( Stabilization of As, Cr, Cu, Pb and Zn in soil using amendments--a review. Kumpiene, J; Lagerkvist, A; Maurice, C, 2008) | 0.35 |
| " Further studies on the transformation of As in soil, grain As bioavailability in the human gastrointestinal tract, and grain elemental speciation trends are critical." | ( Market basket survey shows elevated levels of As in South Central U.S. processed rice compared to California: consequences for human dietary exposure. Feldmann, J; Meharg, AA; Raab, A; Williams, PN, 2007) | 0.34 |
| " The battery of biomarkers tested resulted in showing and linking the bioavailability of various contaminants and sediment characteristics to the toxicity of the different sediments." | ( Biomarkers study for sediment quality assessment in spanish ports using the crab Carcinus maenas and the clam Ruditapes philippinarum. Blasco, J; Delvalls, TA; Martín-Díaz, ML; Sales, D, 2007) | 0.34 |
| " Metal bioavailability was evaluated after 28 days using the earthworm Eisenia fetida (Savigny)." | ( Growth and reproduction of the earthworm Eisenia fetida after exposure to leachate from wood preservatives. Leduc, F; Sunahara, GI; Whalen, JK, 2008) | 0.35 |
| "An in vivo swine assay was utilised for the determination of arsenic (As) bioavailability in contaminated soils." | ( Comparison of in vivo and in vitro methodologies for the assessment of arsenic bioavailability in contaminated soils. Juhasz, AL; Kuchel, T; Naidu, R; Rees, M; Rofe, A; Sansom, L; Smith, E; Weber, J, 2007) | 0.34 |
| "Current English policy and practice allows, and in places encourages, site specific estimates of arsenic oral bioavailability to be used in detailed quantitative human health risk assessment." | ( Incorporating bioaccessibility in detailed quantitative human health risk assessments. Nathanail, CP; Smith, R, 2007) | 0.34 |
| "The mobility and bioavailability of As and Sb in relation to soil-biota transfer were evaluated at a former Sb mining and smelting site (Glendinning, SW Scotland, UK)." | ( Bioavailability of arsenic and antimony in soils from an abandoned mining area, Glendinning (SW Scotland). Cuthbert, S; Gál, J; Hursthouse, A, 2007) | 0.34 |
| "In vitro gastrointestinal (IVG) methods have been developed to provide an expedient and inexpensive means to estimate bioavailability of arsenic and other contaminants from ingestion of contaminated soil." | ( The effect of dosing vehicle on arsenic bioaccessibility in smelter-contaminated soils. Basta, NT; Casteel, SW; Dayton, EA; Foster, JN; Rodriguez, RR, 2007) | 0.34 |
| " These results suggest decreasing As bioaccessibility and bioavailability in soil by adding Fe amendments may be an effective strategy to remediate As-contaminated soils." | ( Decreasing arsenic bioaccessibility/bioavailability in soils with iron amendments. Barnett, MO; Jardine, PM; Stewart, MA; Subacz, JL, 2007) | 0.34 |
| " Actual risk must be evaluated using a weight-of-evidence approach, because natural background levels and site-specific bioavailability will differ both regionally and internationally." | ( The sediments of the Venice Lagoon (Italy) evaluated in a screening risk assessment approach: part II--lagoon sediment quality compared to hot spots, regional, and international case studies. Apitz, SE; Barbanti, A; Bernstein, AG; Bocci, M; Carlin, A; Montobbio, L, 2007) | 0.34 |
| "In vivo models show that the bioavailability of soil contaminants varies between site and type of matrix." | ( In vitro physiologically based extraction test (PBET) and bioaccessibility of arsenic and lead from various mine waste materials. Bruce, S; Matanitobua, V; Ng, J; Noller, B, 2007) | 0.34 |
| " The extraction of elements from sediments with EDTA, to predict the bioavailability of trace and toxic elements, has shown that among them As, Cd and Zn were the most bioavailable elements in lake sediment." | ( Total dissolved and bioavailable elements in water and sediment samples and their accumulation in Oreochromis mossambicus of polluted Manchar Lake. Afridi, HI; Arain, MB; Jalbani, N; Jamali, MK; Kazi, TG; Shah, A, 2008) | 0.35 |
| "The influence of site-specific conditions on contaminant bioavailability and toxicity to benthic invertebrates is a key consideration in the environmental risk assessment process." | ( Effects of arsenic speciation and low dissolved oxygen condition on the toxicity of arsenic to a lotic mayfly. Culp, JM; Irving, EC; Kerrich, R; Liber, K; Lowell, RB; Xie, Q, 2008) | 0.35 |
| " Evaluation of the potential of the amendments as immobilising agents was determined by plant growth (biomass) and elemental accumulation in plant tissues, indicating the bioavailability of As and other heavy metals following amendment." | ( Remediation of arsenic contaminated soils by iron-oxide application, evaluated in terms of plant productivity, arsenic and phytotoxic metal uptake. Hartley, W; Lepp, NW, 2008) | 0.35 |
| "We studied the bioavailability and toxicity of copper, zinc, arsenic, cadmium, and lead in sediments from Lake Roosevelt (LR), a reservoir on the Columbia River in Washington, USA that receives inputs of metals from an upstream smelter facility." | ( Biological and chemical characterization of metal bioavailability in sediments from Lake Roosevelt, Columbia River, Washington, USA. Besser, JM; Brumbaugh, WG; Ingersoll, CG; Ivey, CD; Moran, PW, 2008) | 0.35 |
| ") leaves and to assess As bioavailability in soil." | ( Arsenic bioavailability in the soil amended with leaves of arsenic hyperaccumulator, Chinese brake fern (Pteris vittata L). Cao, Q; Cui, Y; Du, X; Weng, L; Zhu, Y, 2008) | 0.35 |
| " One of the most important factors for successful phytostabilization is monitoring the pollutant bioavailability in the soil." | ( Bioavailability of metals and As from acidified multicontaminated soils: use of white lupin to validate several extraction methods. Carpena, RO; Moreno, E; Vázquez, S, 2008) | 0.35 |
| "There have been significant efforts to establish a widely usable method for the prediction of trace element bioavailability in soil." | ( Trace elements in wild grasses: a phytoavailability study on a remediated field. Burgos, P; Cabrera, F; Madejón, E; Madejón, P; Pérez-de-Mora, A, 2008) | 0.35 |
| " However, few studies have investigated As speciation in these crops while a dearth of information is available on As bioavailability following their consumption." | ( Application of an in vivo swine model for the determination of arsenic bioavailability in contaminated vegetables. Juhasz, AL; Kuchel, T; Naidu, R; Rees, M; Rofe, A; Sansom, L; Smith, E; Weber, J, 2008) | 0.35 |
| "Arsenic (As) bioavailability in spiked soils aged for up to 12 months was assessed using in vitro and in vivo methodologies." | ( Effect of soil ageing on in vivo arsenic bioavailability in two dissimilar soils. Juhasz, AL; Kuchel, T; Naidu, R; Rees, M; Rofe, A; Sansom, L; Smith, E; Weber, J, 2008) | 0.35 |
| " The implications of the results with respect to arsenic species bioavailability and toxicity in marine water are further discussed." | ( The biouptake and toxicity of arsenic species on the green microalga Chlorella salina in seawater. Karadjova, IB; Slaveykova, VI; Tsalev, DL, 2008) | 0.35 |
| " One hundred and eight deep soils were submitted to a four-step, sequential extraction to assess the relative mobility and bioavailability of As in the soil profiles." | ( Distribution and availability of arsenic in soils from the industrialized urban area of Beijing, China. Giesy, JP; Lu, Y; Luo, W; Shi, Y; Wang, G; Wang, T, 2008) | 0.35 |
| " Orpiment and realgar are less soluble and poorly absorbed from the gastrointestinal tract, whereas the bioavailability of arsenic trioxide is similar to inorganic arsenic salts such as sodium arsenite." | ( Mineral arsenicals in traditional medicines: orpiment, realgar, and arsenolite. Goyer, RA; Liu, J; Lu, Y; Waalkes, MP; Wu, Q, 2008) | 0.35 |
| " The results demonstrate that a greatly increased bioavailability of As under the flooded conditions is the main reason for an enhanced As accumulation by flooded rice, and growing rice aerobically can dramatically decrease the As transfer from soil to grain." | ( Growing rice aerobically markedly decreases arsenic accumulation. McGrath, SP; Meharg, AA; Xu, XY; Zhao, FJ, 2008) | 0.35 |
| "There is a strong interest in developing an in vitro arsenic (As) model that satisfactorily estimates the variability in in vivo relative oral bioavailability (RBA) measurements." | ( In vitro model improves the prediction of soil arsenic bioavailability: worst-case scenario. Datta, R; Makris, KC; Nagar, R; Quazi, S; Sarkar, D; Sylvia, VL, 2008) | 0.35 |
| " The results also showed that the distribution of arsenic species in the sediments and their bioavailability in the South Branch of the Yangtze estuary were significantly influenced by the tributary river flows and effluents from the urban area." | ( [Arsenic speciation and bioavailability in the Yangtze estuary in spring, 2006]. Chen, L; Dong, LX; Huang, QH; Li, JH; Ma, ZW, 2008) | 0.35 |
| " A pot experiment in water spinach was conducted to investigate As, Cu and Zn bioavailability in a paddy soil (PS) and a lateritic red soil (LRS) applied with 2% and 4% (mass fraction) chicken manure (CM) and pig manure (PM), respectively." | ( [Bioavailability of As, Cu and Zn in two soils as affected by application of chicken manure and pig manure]. Dang, Z; He, ZH; Li, GL; Yang, BM; Yao, LX; Zhou, CM, 2008) | 0.35 |
| " The development of orally bioavailable organic arsenic derivatives (OAD) offering improved toxicity profiles and better efficacy may expand the use of arsenic derivatives in hematologic malignancies and solid tumors." | ( Chemical and clinical development of darinaparsin, a novel organic arsenic derivative. Chen, YW; Freireich, E; Kantarjian, H; Quintás-Cardama, A; Verstovsek, S; Zingaro, R, 2008) | 0.35 |
| " Due to the elevated arsenic (As) concentration in pond water, it is important to assess the bioavailability and toxicity of As to tilapia for protection of aquatic life and human health." | ( A biotic ligand model-based toxicodynamic approach to predict arsenic toxicity to tilapia gills in cultural ponds. Chen, BC; Chen, WY; Liao, CM, 2009) | 0.35 |
| "The assessment of arsenic (As) bioavailability from contaminated matrices is a crucial parameter for reducing the uncertainty when estimating exposure for human health risk assessment." | ( Principles and application of an in vivo swine assay for the determination of arsenic bioavailability in contaminated matrices. Juhasz, AL; Kuchel, T; Naidu, R; Rees, M; Rofe, A; Sansom, L; Smith, E; Weber, J, 2009) | 0.35 |
| "The bioavailability of arsenic (As) in the soil environment is largely governed by its adsorption-desorption reactions with soil constituents." | ( Sorption and bioavailability of arsenic in selected Bangladesh soils. Huq, SM; Naidu, R; Owens, G; Smith, E, 2009) | 0.35 |
| " Speciation and bioavailability are critical for accurate human health risk assessment, as As species vary in both their toxicity and bioavailability." | ( A comparative study of the extractability of arsenic species from silverbeet and amaranth vegetables. Chen, Z; Naidu, R; Rahman, F, 2009) | 0.35 |
| " It is widely accepted that the inclusion of total soil metal concentrations greatly overestimates the risk through soil ingestion for people due to contaminant bioavailability constraints." | ( Arsenic distribution and bioaccessibility across particle fractions in historically contaminated soils. Juhasz, AL; Smith, E; Weber, J, 2009) | 0.35 |
| "Soil physicochemical characteristics and contamination levels alter the bioavailability of metals to terrestrial invertebrates." | ( Development of a simulated earthworm gut for determining bioaccessible arsenic, copper, and zinc from soil. Ma, WK; Siciliano, SD; Smith, BA; Stephenson, GL, 2009) | 0.35 |
| " We linked the biotic ligand model and damage assessment model to develop a toxicokinetic model for elucidating the site-specific temporal changes of As bioavailability and to characterize how the fish regulate the metal toxicity." | ( Bioavailability links mode of action can improve the long-term field risk assessment for tilapia exposed to arsenic. Chen, WY; Ju, YR; Liao, CM; Tsai, JW, 2009) | 0.35 |
| " Our objective was to evaluate the potential of WTR in lowering soil As bioavailability by conducting in vivo experiments and compare the in vitro to the in vivo As data." | ( Bioavailability and bioaccessibility of arsenic in a soil amended with drinking-water treatment residuals. Datta, R; Makris, KC; Nagar, R; Sarkar, D; Sylvia, VL, 2009) | 0.35 |
| " Reducing uncertainties would require additional soil sampling, epidemic records as well as complementary studies on land use, demographic variation, outdoor activities and bioavailability of arsenic." | ( Health risks from arsenic-contaminated soil in Flin Flon-Creighton, Canada: integrating geostatistical simulation and dose-response model. Huang, GH; Zeng, GM; Zhang, H, ) | 0.13 |
| " In addition, to obtain indications of the contaminants' bioavailability and toxic potential the genotoxicity of the extracts was estimated by testing their ability to inhibit the growth of wildtype Chinese hamster ovary cells (CHO-cells) and three genetically modified phenotypes that are deficient in different DNA-repair mechanisms." | ( Arsenic chemical species-dependent genotoxic potential in water extracts from two CCA-contaminated soils measured by DNA-repair deficient CHO-cells. Lättström, A; Leffler, P; Lövgren, L; Ragnvaldsson, D; Tesfalidet, S; Tysklind, M, 2009) | 0.35 |
| " The difference in the degree of As lixiviation between the three tailing soils was found to be related to the bioavailability of As as well as the original biomass in the tailing soils." | ( Geochemical and microbial effects on the mobilization of arsenic in mine tailing soils. Kim, KW; Kim, SO; Lee, KY, 2010) | 0.36 |
| "Better understanding of the processes controlling arsenic bioavailability in the rhizosphere is important to enhance plant arsenic accumulation by hyperaccumulators." | ( Rhizosphere characteristics of two arsenic hyperaccumulating Pteris ferns. Gonzaga, MI; Ma, LQ; Matias, MI; Santos, JA, 2009) | 0.35 |
| " However, fractionation studies showed that significant amounts of Zn and As could be released to the lake ecosystem depending on the environmental conditions, representing a medium risk potential of bioavailability to the biota." | ( Distribution and partitioning of iron, zinc, and arsenic in surface sediments in the Grande River mouth to Cuitzeo Lake, Mexico. Alfaro-Cuevas, R; Cortés-Martínez, R; Márquez-Benavides, L; Martínez-Miranda, V; Villalobos-Castañeda, B, 2010) | 0.36 |
| " Bioavailability of lead to small mammals, based on concentrations in washed body hair was low." | ( Source-pathway-receptor investigation of the fate of trace elements derived from shotgun pellets discharged in terrestrial ecosystems managed for game shooting. Clemente, R; Lepp, NW; Riby, P; Sneddon, J, 2009) | 0.35 |
| " Here, we investigated the speciation and localization of As and the distribution of (micro)nutrients in rice grains because these are key factors controlling bioavailability of nutrients and contaminants." | ( Speciation and distribution of arsenic and localization of nutrients in rice grains. Carey, AM; Lombi, E; Meharg, AA; Pallon, J; Scheckel, KG; Zhu, YG, 2009) | 0.35 |
| " Its toxicity and bioavailability depend on its speciation, which in turn, depends on microbial transformations, including reduction, oxidation and methylation." | ( Arsenic in contaminated waters: biogeochemical cycle, microbial metabolism and biotreatment processes. Bertin, PN; Lett, MC; Lièvremont, D, 2009) | 0.35 |
| " The developed procedure was applied to evaluate the bioavailability of both elements in four sediment certified reference materials, in which there are not certified values for bioavailable fractions, and also in estuarine sediment samples collected in several sites of Guanabara Bay, an impacted environment in Rio de Janeiro, Brazil." | ( Application of multivariate techniques in the optimization of a procedure for the determination of bioavailable concentrations of Se and As in estuarine sediments by ICP OES using a concomitant metals analyzer as a hydride generator. Bezerra, MA; de Carvalho, Mde F; Lopes, Wda L; Oliveira, EP; Santelli, RE, 2009) | 0.35 |
| " This study reports HIDS for the first time as a promising chelating ligand for the enhancement of Fe bioavailability and As phytoextraction." | ( Hydroxyiminodisuccinic acid (HIDS): A novel biodegradable chelating ligand for the increase of iron bioavailability and arsenic phytoextraction. Hasegawa, H; Kadohashi, K; Maki, T; Rahman, MA; Ueda, K, 2009) | 0.35 |
| " In contrast, the proportion of As(III)-resistant bacteria was dependent on the concentration of As in the soils and a significant positive relationship was found between the bioavailability of As and the proportion of As(III)-resistant bacteria." | ( Microbial community structure and activity in arsenic-, chromium- and copper-contaminated soils. Häggblom, MM; Kairesalo, T; Turpeinen, R, 2004) | 0.32 |
| " The background is clear; arsenic species fulfill seven criteria for a weapon of mass extinction and evolutionary change: (i) bioavailability to all living organisms; (ii) imperceptibility; (iii) acute toxicity; (iv) bioaccumulation and chronic toxicity; (v) adverse impact on reproductive fitness and reproductive outcomes and early-age development and growth in a wide range of microbial, plant and animal species including man; (vi) widespread geographical distribution, mobility and ecological persistence on a centennial to millennial basis and (vii) availability in necessary and sufficient amounts to exert evolutionarily meaningful effects." | ( Gold, coal and oil. Dani, SU, 2010) | 0.36 |
| " fluminea and arsenic bioavailability and toxicokinetics to predict affinity at arsenic-binding site in gills and arsenic body burden." | ( Predicting bioavailability and bioaccumulation of arsenic by freshwater clam Corbicula fluminea using valve daily activity. Chen, WY; Jau, SF; Jou, LJ; Liao, CM, 2010) | 0.36 |
| "Four industrial by-products (phosphogypsum, PG; red gypsum, RG; sugar foam, SF and ashes from the combustion of biomass, ACB) were evaluated as possible amendments for reducing the leachability and bioavailability of As and Se in a metalloid-spiked acidic soil." | ( Assessment of the use of industrial by-products for induced reduction of As, and Se potential leachability in an acid soil. García-González, MT; Garrido, F; Rodríguez-Jordá, MP, 2010) | 0.36 |
| " This study integrated arsenic contents in irrigation water, bioaccumulation factors of paddy soil, cooking methods, and arsenic bioavailability of cooked rice in gastrointestinal tract into a probabilistic risk model." | ( Assessing the arsenic-contaminated rice (Oryza sativa) associated children skin lesions. Chen, WY; Hsieh, NH; Liao, CM; Lin, TL, 2010) | 0.36 |
| " In vitro results were compared to in vivo relative As bioavailability data (swine assay) to ascertain which methodologies best correlate with in vivo data." | ( Assessment of four commonly employed in vitro arsenic bioaccessibility assays for predicting in vivo relative arsenic bioavailability in contaminated soils. Juhasz, AL; Kuchel, T; Naidu, R; Rees, M; Rofe, A; Sansom, L; Smith, E; Weber, J, 2009) | 0.35 |
| " In the first period, a 7-day mass-balance study measured As in food/beverages, urine, and stool to estimate bioavailability of As in food and beverages." | ( Bioavailability of arsenic in soil: pilot study results and design considerations. Barnes, RM; Calabrese, EJ; Danku, JM; Kostecki, PT; Stanek, EJ; Zhou, Y; Zillioux, E, 2010) | 0.36 |
| " Soil properties such as free Fe, clay and organic matter contents appear to have affected the bioavailability of As in the studied soils." | ( Effect of soil properties on arsenic hyperaccumulation in Pteris vittata and Pityrogramma calomelanos var. austroamericana. Kachenko, AG; Singh, B; Xu, W, 2010) | 0.36 |
| " Whether these soils have a higher As bioavailability than other soils containing either geogenic As or contaminated by mining activities was investigated in a pot experiment." | ( Arsenic bioavailability to rice is elevated in Bangladeshi paddy soils. Khan, KA; McGrath, SP; Stroud, JL; Zhao, FJ; Zhu, YG, 2010) | 0.36 |
| " Anthropogenically-accelerated pedogenic processes, which have oxidised this material over time, have greatly enhanced the potential bioavailability of arsenic, with solid-phase arsenic almost solely present as As(V) associated with secondary Fe(III) minerals present." | ( Speciation and transport of arsenic in an acid sulfate soil-dominated catchment, eastern Australia. Collins, RN; Kinsela, AS; Waite, TD, 2011) | 0.37 |
| "We studied the influence of sediment geochemistry on bioavailability of As, Cd, and Cr in deposit-feeding polychaetes." | ( Relating the sediment phase speciation of arsenic, cadmium, and chromium with their bioavailability for the deposit-feeding polychaete Nereis succinea. Baumann, Z; Fisher, NS, 2011) | 0.37 |
| " Future studies needs to evaluate the bioavailability of As and other elements from sikor and their impact on human health." | ( Risk of human exposure to arsenic and other toxic elements from geophagy: trace element analysis of baked clay using inductively coupled plasma mass spectrometry. Al-Rmalli, SW; Haris, PI; Jenkins, RO; Watts, MJ, 2010) | 0.36 |
| " Further in vivo experiments on laboratory animals and analysis of absorption rate and side effects are required." | ( Arsenic trioxide sensitizes cancer stem cells to chemoradiotherapy. A new approach in the treatment of inoperable glioblastoma multiforme. Cernea, D; Cocis, A; Fischer-Fodor, E; Florian, IS; Ioani, H; Irimie, A; Kacso, G; Petrescu, M; Soritau, O; Timis, T; Tomuleasa, C; Virag, P, ) | 0.13 |
| "The complex and variable composition of natural sediments makes it difficult to predict the bioavailability and bioaccumulation of sediment-bound contaminants." | ( Investigating arsenic bioavailability and bioaccumulation by the freshwater oligochaete Lumbriculus variegatus. Di Risio, C; Guerrero, NR; Nasi, M; Piol, MN, 2011) | 0.37 |
| " This suggested that soil pH might play a role in the bioavailability of arsenic." | ( Arsenic concentrations in soils impacted by dam failure of coal-ash pond in Zemianske Kostolany, Slovakia. Hiller, E; Jurkovič, L; Pet'ková, K; Veselská, V, 2011) | 0.37 |
| " It is feasible that we select the bacteria bioleaching solution as a candidate drug, which may be employed for primary change of arsenic compounds including dissolved inorganic arsenic and organic arsenic, in order to improve bioavailability and decrease the amount of arsenic accumulation in animal tissues." | ( [Pharmacokinetics of bacteria bioleaching solution of realgar in rat]. Fan, Q; Li, HY; Zhang, JH, 2010) | 0.36 |
| " Though the arsenic in environment can not be biodegraded as organic contaminants, its bioavailability can be affected by microorganisms via the processes oxidation/reduction, absorption/desorption, methylation/demethylation, and precipitation/dissolution, etc." | ( [Action mechanisms of microorganisms on arsenic and the feasibility of utilizing fungi remediation of arsenic-contaminated soil]. Bai, LY; Li, LF; Su, SM; Zeng, XB, 2010) | 0.36 |
| " This study adds to the evidence for the dominance of dietary uptake of metals in aquatic animals and identifies a key sedimentary fraction of metals that can account for bioavailability of sediment-bound metals." | ( Modeling metal bioaccumulation in a deposit-feeding polychaete from labile sediment fractions and from pore water. Baumann, Z; Fisher, NS, 2011) | 0.37 |
| " The activities and bioavailability of realgar NPs are much influenced by their sizes, making realgar an interesting biomedical and pharmaceutical research candidate." | ( The medicinal use of realgar (As₄S₄) and its recent development as an anticancer agent. Chen, G; Ho, PC; Liu, J; Shao, Y; Wu, J, 2011) | 0.37 |
| "This study was conducted to investigate the effect of external iron status and arsenic species on chelant-enhanced iron bioavailability and arsenic uptake." | ( Effect of external iron and arsenic species on chelant-enhanced iron bioavailability and arsenic uptake in rice (Oryza sativa L.). Hasegawa, H; Kadohashi, K; Maki, T; Rahman, MA; Rahman, MM, 2011) | 0.37 |
| "A pot experiment was conducted to study the effects of exogenous dimethylarsinic acid (DMA) on the growth of Brassica campestris and the bioavailability of soil arsenic (As)." | ( [Effects of exogenous dimethylarsinic acid on Brassica campestris growth and soil arsenic bioavailability]. Bai, LY; He, QH; Hu, LJ; Li, LF; Zeng, XB, 2011) | 0.37 |
| " Cadmium, Hg(II), and MeHg are chloro-complexed, increasing bioavailability for Hg(II) and MeHg, and reducing bioavailability for Cd." | ( Salinity effects on the bioavailability of aqueous metals for the estuarine killifish Fundulus heteroclitus. Dutton, J; Fisher, NS, 2011) | 0.37 |
| " This study demonstrates the dual importance of organic matter (OM), in terms of enhancing arsenic release from soils, while reducing bioavailability by sequestering arsenic in solution." | ( Organic matter-solid phase interactions are critical for predicting arsenic release and plant uptake in Bangladesh paddy soils. Brammer, H; Davison, W; Hossain, M; Islam, MR; Meharg, AA; Norton, GJ; Williams, PN; Zhang, H, 2011) | 0.37 |
| " The trial involved the participation of seven laboratories (five European and two North American) providing bioaccessibility data for As (11 samples), Cd (9 samples) and Pb (13 samples) using soils with in vivo relative bioavailability data measured using a swine model." | ( An inter-laboratory trial of the unified BARGE bioaccessibility method for arsenic, cadmium and lead in soil. Basta, N; Brandon, E; Casteel, S; Cave, M; Denys, S; Gron, C; Oomen, A; Reimer, K; Tack, K; Van de Wiele, T; Wragg, J, 2011) | 0.37 |
| "Assessment of soil arsenic (As) bioavailability may profoundly affect the extent of remediation required at contaminated sites by improving human exposure estimates." | ( Relative bioavailability and bioaccessibility and speciation of arsenic in contaminated soils. Bradham, KD; Gilmore, T; Harper, S; Hughes, MF; Lee, GE; Miller, BW; Nelson, CM; Scheckel, KG; Seales, PE; Serda, SM; Thomas, DJ; Yeow, A, 2011) | 0.37 |
| "We evaluated inexpensive methods for assessing As bioavailability in soil as a means to improve human exposure estimates and potentially reduce remediation costs." | ( Relative bioavailability and bioaccessibility and speciation of arsenic in contaminated soils. Bradham, KD; Gilmore, T; Harper, S; Hughes, MF; Lee, GE; Miller, BW; Nelson, CM; Scheckel, KG; Seales, PE; Serda, SM; Thomas, DJ; Yeow, A, 2011) | 0.37 |
| " Arsenic bioavailability was determined using an in vivo mouse model, and As bioaccessibility was determined using the Solubility/Bioavailability Research Consortium in vitro assay." | ( Relative bioavailability and bioaccessibility and speciation of arsenic in contaminated soils. Bradham, KD; Gilmore, T; Harper, S; Hughes, MF; Lee, GE; Miller, BW; Nelson, CM; Scheckel, KG; Seales, PE; Serda, SM; Thomas, DJ; Yeow, A, 2011) | 0.37 |
| "The multifaceted approach described here yielded congruent estimates of As bioavailability and evidence of interrelations among physicochemical properties and bioavailability estimates." | ( Relative bioavailability and bioaccessibility and speciation of arsenic in contaminated soils. Bradham, KD; Gilmore, T; Harper, S; Hughes, MF; Lee, GE; Miller, BW; Nelson, CM; Scheckel, KG; Seales, PE; Serda, SM; Thomas, DJ; Yeow, A, 2011) | 0.37 |
| " It seems that the most important indicators to be used to assess the restoration of sulfide mine soils are those related with bioavailability of trace elements and soil enzymatic activities." | ( Soil quality indicators response to application of hydrophilic polymers to a soil from a sulfide mine. Cordovil, C; de Varennes, A; Gonçalves, P; Qu, G, 2011) | 0.37 |
| "Sequential extraction procedure (SEP) and a physiologically based extraction test (PBET) were performed with the aim to estimate the mobility, bioavailability (for plants and humans) and spatial variation of arsenic in agricultural soils in the Valleys of Arica and Parinacota Region (Northern Chile)." | ( Fractionation and bioavailability of arsenic in agricultural soils: solvent extraction tests and their relevance in risk assessment. Acarapi-Cartes, J; Cornejo-Ponce, L, 2011) | 0.37 |
| " Arsenic speciation in raw and cooked rice, its bioavailability and the possible health hazard of inorganic arsenic in rice for the population of S and SE Asia have been discussed in this review." | ( High levels of inorganic arsenic in rice in areas where arsenic-contaminated water is used for irrigation and cooking. Hasegawa, H; Rahman, MA, 2011) | 0.37 |
| " Arsenic bioaccessibility was compared to previous published As relative bioavailability data for these soils to determine the correlation between in vitro and in vivo data." | ( Influence of saliva, gastric and intestinal phases on the prediction of As relative bioavailability using the Unified Bioaccessibility Research Group of Europe Method (UBM). Juhasz, AL; Smith, E; Weber, J, 2011) | 0.37 |
| " However, little attention has been paid to estimate the bioaccessibility and/or bioavailability of arsenosugars in edible seaweed and their possible degradation products during gastrointestinal digestion." | ( Two-dimensional HPLC coupled to ICP-MS and electrospray ionisation (ESI)-MS/MS for investigating the bioavailability in vitro of arsenic species from edible seaweed. Barciela-Alonso, Mdel C; Bermejo-Barrera, P; Garcia-Sartal, C; Goenaga-Infante, H; Stokes, E; Taebunpakul, S, 2012) | 0.38 |
| "A number of in vitro assays are available for the determination of arsenic (As) bioaccessibility and prediction of As relative bioavailability (RBA) to quantify exposure for site-specific risk assessment." | ( Predicting arsenic relative bioavailability in contaminated soils using meta analysis and relative bioavailability-bioaccessibility regression models. Juhasz, AL; Smith, E; Weber, J, 2011) | 0.37 |
| " It is known that a significant portion of some forms of mineral arsenicals is poorly absorbed into the body, and would be unavailable to cause systemic damage." | ( Arsenic in cancer treatment: challenges for application of realgar nanoparticles (a minireview). Baláž, P; Sedlák, J, 2010) | 0.36 |
| "7 at MONT) in the ERA resulted in lower numeric risk than compared to risk calculated with 100% bioavailability (hazard quotient=180 at USH; 75 at LSH; and 680 at MONT)." | ( Inclusion of soil arsenic bioaccessibility in ecological risk assessment and comparison with biological effects. Knopper, LD; Koch, I; Reimer, KJ; Saunders, JR, 2011) | 0.37 |
| " Although soils from La Soterraña were less polluted, arsenic bioavailability was much higher than in Los Rueldos." | ( A methodological approach to evaluate arsenic speciation and bioaccumulation in different plant species from two highly polluted mining areas. Fernández-Martínez, R; Larios, R; Lehecho, I; Rucandio, I, 2012) | 0.38 |
| " The remediation was evaluated based on Pb and As bioavailability, assessed by means of a selective non-exhaustive chemical extraction (modified Morgan extraction, MME), with a physiologically based extraction test (PBET) for the assessment of Pb and As bioavailability in ingested soils and with a novel in vivo bioaccumulation test with isopods (Porcellio scaber)." | ( Influence of compost addition on lead and arsenic bioavailability in reclaimed orchard soil assessed using Porcellio scaber bioaccumulation test. McBride, MB; Udovic, M, 2012) | 0.38 |
| " It is shown that the bioavailability of As is influenced by a complex interplay of partly counteracting processes." | ( Impact of irrigation with high arsenic burdened groundwater on the soil-plant system: Results from a case study in the Inner Mongolia, China. Guo, H; Neidhardt, H; Norra, S; Stüben, D; Tang, X, 2012) | 0.38 |
| " The purpose of this study was to synthesize water chemistry-based bioavailability and valve daily rhythm in Corbicula fluminea to design a biomonitoring system for detecting waterborne As." | ( A real-time biomonitoring system to detect arsenic toxicity by valve movement in freshwater clam Corbicula fluminea. Chen, SH; Chen, WY; Jou, LJ; Liao, CM, 2012) | 0.38 |
| " vittata was treated with different concentrations of As and/or Cd in a hydroponic system, that is, under complete bioavailability of the elements, with the objective of investigating the effects of these two elements and their interactions." | ( Effects of cadmium and arsenic on Pteris vittata under hydroponic conditions. Cornara, L; Drava, G; Manfredi, A; Minganti, V; Roccotiello, E, 2012) | 0.38 |
| "The relative bioavailability of arsenic, antimony, cadmium, and lead for the ingestion pathway was measured in 16 soils contaminated by either smelting or mining activities using a juvenile swine model." | ( In vivo validation of the unified BARGE method to assess the bioaccessibility of arsenic, antimony, cadmium, and lead in soils. Caboche, J; Cave, M; Denys, S; Feidt, C; Jondreville, C; Rychen, G; Tack, K; Wragg, J, 2012) | 0.38 |
| " Some studies revealed that trivalent organoarsenic species are well absorbed in the intestine compared to iAs." | ( Arsenic undergoes significant speciation changes upon incubation of contaminated rice with human colon micro biota. Alava, P; Laing, GD; Tack, F; Van de Wiele, T, 2013) | 0.39 |
| " The time- and concentration-dependent progressive nature of the lung and blood effects together with bioavailability data on gallium and arsenic lead us to conclude that the testicular/sperm effects are secondary to hypoxemia resulting from lung damage rather than due to a direct chemical effect of gallium or arsenide." | ( Evaluation of the male reproductive toxicity of gallium arsenide. Bomhard, EM; Cohen, SM; Gelbke, HP; Williams, GM, 2012) | 0.38 |
| "The bioavailability and mobility of arsenic (As) in soils depends on several factors such as pH, organic matter content, speciation, and the concentration of oxides and clay minerals, among others." | ( Arsenic localization and speciation in the root-soil interface of the desert plant Prosopis juliflora-velutina. Castillo-Michel, H; Gardea-Torresdey, JL; Hernandez-Viezcas, JA; Peralia-Videa, JR; Servin, A, 2012) | 0.38 |
| "Experience in the treatment of patients with acute promyelocytic leukaemia (APL) and accelerated phase chronic myeloid leukaemia with orally administered arsenic trioxide (ATO) in our institution since 1999 has demonstrated that bioavailability of oral ATO is comparable with intravenous administration, and similar outcomes are produced in treatment of APL." | ( Oral administration of arsenic trioxide in the treatment of acute promyelocytic leukaemia and accelerated phase chronic myeloid leukaemia: an Australian single-centre study. Firkin, F, 2012) | 0.38 |
| " Root exudate (organic acids) solution was suitable for assessing As bioavailability (81%) in the soils while Mehlich III (31%) overestimated the amount of As taken up by plants." | ( Predicting arsenic bioavailability to hyperaccumulator Pteris vittata in arsenic-contaminated soils. dos Santos, WM; Gonzaga, MI; Ma, LQ; Pacheco, EP, 2012) | 0.38 |
| " Ecological impacts of amending soils with As-laden litter depend on the As species in the litter, and chemical and physical properties of soil that strongly affect As mobility and bioavailability in the environment." | ( Arsenic species in broiler (Gallus gallus domesticus) litter, soils, maize (Zea mays L.), and groundwater from litter-amended fields. Beck, EG; D'Angelo, E; Grove, J; Sikora, F; Zeigler, G, 2012) | 0.38 |
| " This suggests that microbial reduction of highly bioavailable As(V)-bearing Fe(III) mineral does not necessarily result in the mobilization of the arsenic." | ( Microbial reduction of arsenic-doped schwertmannite by Geobacter sulfurreducens. Arenholz, E; Coker, VS; Cutting, RS; Kimber, RL; Lloyd, JR; Pattrick, RA; Telling, ND; van der Laan, G; Vaughan, DJ, 2012) | 0.38 |
| "The aim of this study was to evaluate the bioavailability of arsenic (As) through cultured oyster Crassostrea gigas and Crassostrea corteziensis from four coastal lagoons (SE Gulf of California)." | ( Arsenic and arsenic species in cultured oyster (Crassostrea gigas and C. corteziensis) from coastal lagoons of the SE Gulf of California, Mexico. Bergés-Tiznado, ME; Notti, A; Páez-Osuna, F; Regoli, F, 2013) | 0.39 |
| "In this work, the nexus between sorption and bioavailability of arsenic (As) and cadmium (Cd) as affected by soil type, soil pH, ageing, and mobilizing agents were examined." | ( Sorption-bioavailability nexus of arsenic and cadmium in variable-charge soils. Bolan, N; Kunhikrishnan, A; Mahimairaja, S; Naidu, R, 2013) | 0.39 |
| " Bioavailability or mobility of inorganic As in soil has been reported to be significantly influenced by soil minerals such as iron (hydr) oxide; however, the interactions of organic As such as monosodium methanearsonate (MSMA) with soil minerals are little studied, thus largely unknown." | ( Response of rice genotype to straighthead disease as influenced by arsenic level and water management practices in soil. Hua, B; Yan, W; Yang, J, 2013) | 0.39 |
| "This work investigates arsenic mobility, bioavailability and toxicity in marine port sediments using chemical sequential extraction and laboratory toxicity tests." | ( Arsenic in marine sediments from French Mediterranean ports: geochemical partitioning, bioavailability and ecotoxicology. Battaglia-Brunet, F; Galgani, F; Géret, F; Hurel, C; Mamindy-Pajany, Y; Marmier, N; Roméo, M, 2013) | 0.39 |
| "In this study, we examined the bioavailability of arsenic through the mangrove oyster Crassostrea corteziensis sampled from seven coastal lagoons in SE Gulf of California during the rainy and dry seasons." | ( Biomonitoring of arsenic through mangrove oyster (Crassostrea corteziensis Hertlein, 1951) from coastal lagoons (SE Gulf of California): occurrence of arsenobetaine and other arseno-compounds. Bergés-Tiznado, ME; Notti, A; Páez-Osuna, F; Regoli, F, 2013) | 0.39 |
| " The objectives of this research are to: (1) assess whether microbes in the in vitro small intestine affect arsenic solubilization from soils, (2) determine whether differences in the GI microbial community result in differences in the oral bioavailability of soil-borne arsenic." | ( An investigation of the effect of gastrointestinal microbial activity on oral arsenic bioavailability. Casteel, SW; Dodd, M; James, KJ; Laird, BD; Siciliano, SD; Van de Wiele, TR; Wickstrom, M, 2013) | 0.39 |
| "), soil As fractionation, and in vivo bioavailability is needed in order to determine if F1+F2 are the bioavailable As fractions in soils that vary in total As content and sorbed As species." | ( Bioaccessible and non-bioaccessible fractions of soil arsenic. Basta, NT; Dayton, EA; Whitacre, SD, 2013) | 0.39 |
| " The antagonistic effects might be because Fe reduced As bioavailability and accumulation, which was verified by As and Fe levels in feces and liver." | ( Impact of iron precipitant on toxicity of arsenic in water: a combined in vivo and in vitro study. Cui, Y; Guo, X; Liu, S; Wu, B; Zhang, X; Zhang, Y, 2013) | 0.39 |
| " The redworm bioassay indicated Pb (but not As) bioavailability to be reduced by soil amendment with compost, a result consistent with the ammonium acetate extraction test but not reflected in modified BCR test." | ( Extractability and bioavailability of Pb and As in historically contaminated orchard soil: effects of compost amendments. Fleming, M; McBride, MB; Tai, Y; Zhuang, P, 2013) | 0.39 |
| "The mobility and bioavailability of As combining with amorphous Fe oxides is vulnerable to the environment." | ( [Chemical extraction of arsenic co-precipitated with amorphous Fe (OH)3 and Fe3O4]. Chen, YP; Jia, YF; Wang, SF, 2013) | 0.39 |
| " Moreover the use of bioassay demonstrated that mycorrhiza and clay particle reduced arsenic bioavailability in soil." | ( Effect of arsenic contaminated irrigation water on Lens culinaris L. and toxicity assessment using lux marked biosensor. Ahmed, FR; Alexander, IJ; Killham, K; Mwinyihija, M, 2012) | 0.38 |
| " Results showed that iron-based amendments were able to reduce the leaching and the bioavailability of trace elements in the sediment sample, while zeolite was unsuitable." | ( Comparison of mineral-based amendments for ex-situ stabilization of trace elements (As, Cd, Cu, Mo, Ni, Zn) in marine dredged sediments: a pilot-scale experiment. Geret, F; Hurel, C; Mamindy-Pajany, Y; Marmier, N; Roméo, M, 2013) | 0.39 |
| " Bioavailability of arsenic in water and sediments is strongly influenced by such microbial activities." | ( Bacterial metabolism of environmental arsenic--mechanisms and biotechnological applications. Arsène-Ploetze, F; Bertin, PN; Heipieper, HJ; Kruger, MC, 2013) | 0.39 |
| "This report summarizes the results of a study to develop an in vitro bioaccessibility (IVBA) extraction technique for estimating the relative bioavailability (RBA) of arsenic (As) in soil." | ( An in vitro method for estimation of arsenic relative bioavailability in soil. Brattin, W; Diamond, G; Drexler, J; Griffin, S; Lowney, Y; Woodbury, L, 2013) | 0.39 |
| "Phosphorus (P) influences arsenic (As) mobility and bioavailability which depends on the charge components of soil." | ( Phosphorus-arsenic interactions in variable-charge soils in relation to arsenic mobility and bioavailability. Bolan, N; Choppala, G; Kunhikrishnan, A; Mahimairaja, S, 2013) | 0.39 |
| "The mobility and bioavailability of As in the soil-plant system can be affected by a number of organic acids that originate from the activity of plants and microorganisms." | ( Arsenic mobilization by citrate and malate from a red mud-treated contaminated soil. Castaldi, P; Deiana, S; Garau, G; Mele, E; Silvetti, M, ) | 0.13 |
| "Determination of oxidation states of solid-phase arsenic in bulk sediments is a valuable step in the evaluation of its bioavailability and environmental fate in deposits, but is difficult when the sediments have low arsenic contents and heterogeneous distribution of arsenic species." | ( Arsenic K-edge X-ray absorption near-edge spectroscopy to determine oxidation states of arsenic of a coastal aquifer-aquitard system. Jiao, JJ; Li, Y; Wang, Y; Zhu, S, 2013) | 0.39 |
| " The available data on mode of action (MOA), genotoxicity and bioavailability do not support the contribution of As or Ga ions to the lung tumors in female rats." | ( Evaluation of the carcinogenicity of gallium arsenide. Bomhard, EM; Cohen, SM; Gelbke, HP; Schenk, H; Williams, GM, 2013) | 0.39 |
| "In this work, bioavailability and ecotoxicity of arsenite (As(III)) and arsenate (As(V)) species were compared between solution culture and soil system." | ( Bioavailability and ecotoxicity of arsenic species in solution culture and soil system: implications to remediation. Bolan, N; Kunhikrishnan, A; Mahimairaja, S; Seshadri, B; Thangarajan, R, 2015) | 0.42 |
| "A suitable test organism for assessing the bioavailability of sediment-bound metals should accumulate metals mainly from the sediment instead of other sources such as water." | ( Rapid assessments of metal bioavailability in marine sediments using coelomic fluid of sipunculan worms. Ke, C; Tan, QG; Wang, WX, 2013) | 0.39 |
| " For soil As, all the three amendments could transform the non-specifically adsorbed As fraction to hydrous oxides Fe/Al fractions (by Fe(0) and red mud) or specifically adsorbed As fraction (by zeolite), therefore reduced the bioavailability of soil As." | ( Arsenic stabilization by zero-valent iron, bauxite residue, and zeolite at a contaminated site planting Panax notoginseng. Liao, XY; Lin, LY; Wen, Y; Yan, XL; Zhang, WB, 2013) | 0.39 |
| "The chemical speciation and distribution of potentially toxic metal(loid)s in mine wastes is critical to assessing the risks posed by these wastes and predicting the potential bioavailability of the metal(loid)s present." | ( (Micro)spectroscopic analyses of particle size dependence on arsenic distribution and speciation in mine wastes. Akau, J; Chi, C; Kim, CS; Miller, SR; Rosales, RA; Rytuba, JJ; Sugihara, ES; Webb, SM, 2013) | 0.39 |
| " Among others effects of thio-DMA(V) on eight cell death related endpoints, cell cycle distribution, genotoxicity, cellular bioavailability as well as for the first time its impact on DNA damage induced poly(ADP-ribosyl)ation were investigated and compared to effects induced by arsenite." | ( Toxicological properties of the thiolated inorganic arsenic and arsenosugar metabolite thio-dimethylarsinic acid in human bladder cells. Beneke, S; Berndt, S; Bürkle, A; Ebert, F; Leffers, L; Mangerich, A; Schwerdtle, T; Weber, T, 2014) | 0.4 |
| " In this way, changes in the mobility and bioavailability of soil contaminants due to changes in geochemical soil properties via soil dilution were studied." | ( Risk assessment of an abandoned pyrite mine in Spain based on direct toxicity assays. Esteban, E; Fernández, MD; García-Gómez, C; Peñalosa, JM; Sánchez-Pardo, B, 2014) | 0.4 |
| " Bioavailability of metal(loid)s plays a vital role in the remediation of contaminated soils." | ( Remediation of heavy metal(loid)s contaminated soils--to mobilize or to immobilize? Bolan, N; Kirkham, MB; Kumpiene, J; Kunhikrishnan, A; Makino, T; Park, J; Scheckel, K; Thangarajan, R, 2014) | 0.4 |
| " The addition of the biochars decreased the adsorption of As (V) by brown soil, which could induce the increase of the bioavailability of As, and strengthen the toxicity of As in soil." | ( [Effects of biochars produced from different sources on arsenic adsorption and desorption in soil]. Chan, ZX; Guan, LZ; Zhang, GC; Zhang, JH; Zhang, Y; Zhou, JJ, 2013) | 0.39 |
| " In addition, a pharmacokinetics study performed in rats indicated that the relative bioavailability of realgar NPs was 216." | ( Enhanced antitumor activity of realgar mediated by milling it to nanosize. Gao, G; Jiang, S; Li, Z; Liu, D; Pan, W; Tian, Y; Wang, X; Xi, R; Zhao, Y, 2014) | 0.4 |
| " Influence of pH on As bioavailability was visible as the available As concentration was higher in acidic soil compared to alkaline soil." | ( Effect of soil pH on as hyperaccumulation capacity in fern species, Pityrogramma calomelanos. Anh, BT; Hue, NT; Kim, DD; Kuschk, P; Minh, NN; Tua, TV, 2013) | 0.39 |
| " According to the characters of chemistry, mobility, and bioavailability of metals in urban street dust, we estimated the hazards on the environment and human health, which will help us to get more reasonable information for risk management of metals in urban environment." | ( Human health risk assessment based on toxicity characteristic leaching procedure and simple bioaccessibility extraction test of toxic metals in urban street dust of Tianjin, China. Wang, Y; Yu, B; Zhou, Q, 2014) | 0.4 |
| " In this study, the bioavailability and accumulation of arsenate in the species Brassica juncea were compared between soil system and hydroponics in relation to P and S concentration of the growth substrate." | ( Effects of phosphate and thiosulphate on arsenic accumulation in the species Brassica juncea. Grifoni, M; Malagoli, M; Petruzzelli, G; Pezzarossa, B; Schiavon, M, 2015) | 0.42 |
| " Despite the highest bioavailability of contaminants, most of the soil microbial and biochemical features monitored (i." | ( Stabilising metal(loid)s in soil with iron and aluminium-based products: microbial, biochemical and plant growth impact. Castaldi, P; Deiana, P; Deiana, S; Garau, G; Mele, E; Silvetti, M, 2014) | 0.4 |
| "An Escherichia coli arsRp::luc-based biosensor was constructed to measure the bioavailability of arsenic (As) in soil." | ( The impacts of different long-term fertilization regimes on the bioavailability of arsenic in soil: integrating chemical approach with Escherichia coli arsRp::luc-based biosensor. Bai, ZH; Hou, QH; Lv, D; Ma, AZ; Zhuang, GQ; Zhuang, XL, 2014) | 0.4 |
| " Although the As levels in the vegetables were not high and the bioavailability of As in the soils was quite low, long-term consumption may result in higher As intake in the human body." | ( Food safety and bioavailability evaluations of four vegetables grown in the highly arsenic-contaminated soils on the Guandu Plain of northern Taiwan. Chen, ZS; Lai, HY; Su, SW; Tsui, CC, 2014) | 0.4 |
| " Toxicity of As species to aquatic organisms is complicated by their interaction with chemicals in water such as phosphate that can influence the bioavailability and uptake of As(V)." | ( Toxicity of arsenic species to three freshwater organisms and biotransformation of inorganic arsenic by freshwater phytoplankton (Chlorella sp. CE-35). Doyle, C; Duncan, E; Hassler, C; Hogan, B; Krassoi, R; Lim, RP; Maher, W; Naidu, R; Rahman, MA; Rahman, MM, 2014) | 0.4 |
| " In the present study, we investigated foliar application or a field with highly bioavailable arsenic (As) to screen As-accumulating plants." | ( Screening of As-accumulating plants using a foliar application and a native accumulation of As. Hatayama, M; Huang, Y; Inoue, C; Sugawara, K; Zhang, Z, 2014) | 0.4 |
| " In this study a systematic investigation of the As-Sb-Tl contamination of soils and their bioavailability was carried out using the extraction procedure in order to explore the mobility and potential bioavailability of the As, Sb, and Tl." | ( Bioaccumulation of heavy metals by endemic Viola species from the soil in the vicinity of the As-Sb-Tl mine "allchar' Republic of Macedonia. Baceva, K; Matevski, V; Stafilov, T, 2014) | 0.4 |
| " Metal(loid) bioavailability was assessed after soil contamination, whereas plant growth, metal(loid) concentration in plant organs and DNA damage were measured at the end of plant exposition." | ( The combined toxic and genotoxic effects of Cd and As to plant bioindicator Trifolium repens L. Citterio, S; Fumagalli, P; Gentili, R; Ghiani, A; Nguyen Van, T, 2014) | 0.4 |
| "Elemental chemical speciation in atmospheric particles determining their bioavailability and toxicity is an implication for human health assessment." | ( Fractionation and health risks of atmospheric particle-bound As and heavy metals in summer and winter. Chen, Y; Hu, X; Lian, H; Sun, Y; Wu, J, 2014) | 0.4 |
| "Iron (Fe) has been widely applied to treat arsenic (As)-contaminated water, and Fe could influence bioavailability and toxicity of As." | ( Metagenomic profiles and antibiotic resistance genes in gut microbiota of mice exposed to arsenic and iron. Guo, X; Li, M; Liu, S; Wang, Z; Wu, B; Zhang, XX, 2014) | 0.4 |
| ") route to establish its dose-response relationship in terms of bioavailability and pharmacokinetic parameters." | ( Bioavailability and pharmacokinetics of arsenic are influenced by the presence of cadmium. Diacomanolis, V; Ng, JC; Noller, BN, 2014) | 0.4 |
| " Discussion of the health risk of As in rice has largely been based on its inorganic arsenic content because these species have generally been considered to be more toxic than MMA and DMA and can be directly compared to As in drinking water, assuming equal bioavailability of inorganic As in the rice matrix and in water." | ( Arsenic toxicity in rice with special reference to speciation in Indian grain and its implication on human health. Bhattacharyya, K; Sinha, B, 2015) | 0.42 |
| " In situ intestinal re-circulating perfusion experiments showed that the absorption rate of fluorescein isothiocyanate (FITC)-labeled OVA in the distal intestine was higher than that for a marker of non-specific absorption, FITC-dextran (FD-40), and that colchicine, a general endocytosis inhibitor, suppressed OVA absorption." | ( Characterization of ovalbumin absorption pathways in the rat intestine, including the effects of aspirin. Matsuo, H; Nouma, H; Yokooji, T, 2014) | 0.4 |
| " From the data obtained in this study, we can conclude that DGT is an effective technique for the prediction and assessment of As bioavailability in soils." | ( Assessment of arsenic availability in soils using the diffusive gradients in thin films (DGT) technique--a comparison study of DGT and classic extraction methods. Bai, L; Su, S; Wang, J; Wang, Y; Wu, C; Zeng, X, 2014) | 0.4 |
| " To achieve an equivalent effect, a 10-fold dosage of genistein was required, thus highlighting the dose advantage of resveratrol, as poor bioavailability is a common concern for its clinical application." | ( Arsenic trioxide and resveratrol show synergistic anti-leukemia activity and neutralized cardiotoxicity. Chen, M; Fan, Y; Fang, K; Meng, J; Tu, Y; Wan, L; Yu, L; Zhu, W, 2014) | 0.4 |
| "To evaluate the capabilities of in vitro assays to predict arsenic (As) relative bioavailability (RBA), we examined the relationship between As bioaccessibility, determined using a number of in vitro bioaccessibility (IVBA) methodologies (SBRC, IVG, PBET, DIN and UBM) and As RBA determined in a mouse assay for nine As-contaminated soils and 1 NIST reference material (2710a)." | ( Variability associated with as in vivo-in vitro correlations when using different bioaccessibility methodologies. Bradham, K; Juhasz, AL; Nelson, C; Smith, E; Thomas, DJ, 2014) | 0.4 |
| " Innovative approaches included use of tissue-based toxicity reference values (TRVs), adjustment of bioavailability in the dietary uptake models (using sequential metal extractions in sediment), partitioning chemical species into uptake compartments (e." | ( Evaluating risks to wildlife from coal fly ash incorporating recent advances in metals and metalloids risk assessment. Iannuzzi, J; Meyer, CB; Schlekat, TH; Souza, MJ; Walls, SJ, 2015) | 0.42 |
| " We conclude that dietary background is a crucial parameter to incorporate when predicting bioavailability with bioaccessibility measurements and when assessing health risks from As following oral exposure." | ( Westernized diets lower arsenic gastrointestinal bioaccessibility but increase microbial arsenic speciation changes in the colon. Alava, P; De Ryck, T; Du Laing, G; Tack, F; Van De Wiele, T, 2015) | 0.42 |
| " In addition, drug release, bioavailability and antitumour studies were also performed." | ( Realgar nanoparticle-based microcapsules: preparation and in-vitro/in-vivo characterizations. Feng, N; Omari-Siaw, E; Shi, F, 2015) | 0.42 |
| " RN and RNM exhibited considerable higher release of As2 S2 , bioavailability and antitumour efficacies compared with crude realgar." | ( Realgar nanoparticle-based microcapsules: preparation and in-vitro/in-vivo characterizations. Feng, N; Omari-Siaw, E; Shi, F, 2015) | 0.42 |
| " The obtained results indicate a reduction in arsenic mobility and bioavailability in all matured composts and vermicomposts." | ( Effects of combined composting and vermicomposting of waste sludge on arsenic fate and bioavailability. Hofman, J; Kuta, J; Maňáková, B; Svobodová, M, 2014) | 0.4 |
| "A number of bioaccessibility methodologies have the potential to act as surrogate measures of arsenic (As) relative bioavailability (RBA), however, validation of the in vivo-in vitro relationship is yet to be established." | ( Validation of the predictive capabilities of the Sbrc-G in vitro assay for estimating arsenic relative bioavailability in contaminated soils. Boland, J; Herde, C; Herde, P; Juhasz, AL; Smith, E, 2014) | 0.4 |
| " However, compared to soils, assessment of As relative bioavailability (RBA) in household dust is limited." | ( Correlation of in vivo relative bioavailability to in vitro bioaccessibility for arsenic in household dust from China and its implication for human exposure assessment. Juhasz, AL; Li, HB; Li, J; Ma, LQ, 2014) | 0.4 |
| " For a good estimation of the risks of arsenic in food, it is important to investigate if the bioavailability of inorganic arsenic from food is different from drinking water." | ( Arsenic: bioaccessibility from seaweed and rice, dietary exposure calculations and risk assessment. Brandon, EF; de Wit-Bos, L; Janssen, PJ, 2014) | 0.4 |
| "This study was conducted to investigate the contribution of a site-specific bioavailability of arsenic (As) to human health risk at an old abandoned smelter site in Korea." | ( Determination of human health risk incorporating experimentally derived site-specific bioaccessibility of arsenic at an old abandoned smelter site. Im, J; Jeong, S; Nam, K; Yang, K, 2015) | 0.42 |
| " Perhaps soil arsenic was easily dissolved in the soil solution and the bioavailability of AsS, treatment was better than that of AsS, treatment." | ( [Influence of sulfur on the bioavailability of arsenic uptake by rice (Oryza. sativa L. ) and its speciation in soil ]. Rao, W; Tang, BP; Wang, D; Wang, DC; Yang, SJ; Zhang, YN; Zhu, YJ, 2014) | 0.4 |
| "Using by sequential extraction procedures to obtain the chemical forms of arsenic in soils can provide useful information for the assessment of arsenic mobility and bioavailability in soils." | ( Effect of sample pretreatment on the fractionation of arsenic in anoxic soils. Chen, Z; Huang, G; Liu, F; Sun, J; Wang, J; Zhang, Y, 2015) | 0.42 |
| " Compared to arsenate, there were more marked changes in the arsenite concentrations in the soil solution as water management shifted, and therefore arsenite concentrations dominated the As speciation and bioavailability in the soil." | ( Effects of water management on arsenic and cadmium speciation and accumulation in an upland rice cultivar. Christie, P; Hu, P; Luo, Y; Ouyang, Y; Shen, L; Wu, L, 2015) | 0.42 |
| "The effect of iron (Fe) redox cycling on the mobility and bioavailability of arsenic (As) in paddy soils has attracted increasing concerns, especially in Asia, where the paddy soil is characteristic of Fe with high abundance and activity." | ( Arsenic availability in rice from a mining area: is amorphous iron oxide-bound arsenic a source or sink? Li, F; Liu, C; Wang, Q; Xu, X; Yu, HY, 2015) | 0.42 |
| " The chemical partitioning patterns indicated that the potential for Mn, Pb, Zn, Cu, Cd, and As remobilization and bioavailability is low, as most of these elements were present in the residual and/or the more stable Mn- and Fe-hydroxide fractions." | ( Chemical assessment and fractionation of some heavy metals and arsenic in agricultural soils of the mining affected Drama plain, Macedonia, northern Greece. Michailidis, K; Sofianska, E, 2015) | 0.42 |
| " In conclusion, data suggest that arsenic-induced reduction in vasomotion frequency of the isolated aortic rings is associated with a decreased bioavailability of NO, an increase in QTc and a decrease in the frequency of the pulse wave generated by the cardiac cycle in anesthetized rats." | ( Synchronization in the Heart Rate and the Vasomotion in Rat Aorta: Effect of Arsenic Trioxide. Cifuentes, F; Nwokocha, CR; Palacios, J, 2016) | 0.43 |
| "Delivery of arsenic trioxide (ATO), a clinical anticancer drug, has drawn much attention to improve its pharmacokinetics and bioavailability for efficient cancer therapy." | ( Real-time monitoring of arsenic trioxide release and delivery by activatable T(1) imaging. Chi, X; Gao, J; Li, H; Liu, H; Wang, X; Yin, Z; Zhang, H; Zhang, Z; Zhao, Z; Zhu, X, 2015) | 0.42 |
| "In vitro bioaccessibility (IVBA) assays estimate arsenic (As) relative bioavailability (RBA) in contaminated soils to improve accuracy in human exposure assessments." | ( Independent data validation of an in vitro method for the prediction of the relative bioavailability of arsenic in contaminated soils. Bradham, KD; Juhasz, AL; Miller, BW; Nelson, C; Obenour, DR; Scheckel, K; Smith, E; Thomas, DJ, 2015) | 0.42 |
| " Nevertheless, soil properties did not show, in general, a high relation with studied toxicity endpoints, although the high correlation with AsW could greatly reduce indirectly As bioavailability and toxicity risk for earthworms." | ( Influence of soil properties on the bioaccumulation and effects of arsenic in the earthworm Eisenia andrei. Ortiz, MD; Peinado, FJ; Romero-Freire, A; van Gestel, CA, 2015) | 0.42 |
| "The effect of soil washing used for arsenic (As)-contaminated soil remediation on soil properties and bioavailability of residual As in soil is receiving increasing attention due to increasing interest in conserving soil qualities after remediation." | ( Effect of different soil washing solutions on bioavailability of residual arsenic in soils and soil properties. Im, J; Jho, EH; Nam, K; Yang, K, 2015) | 0.42 |
| "Arsenic bioavailability in rock, soil and water resources is notoriously hazardous." | ( High soil and groundwater arsenic levels induce high body arsenic loads, health risk and potential anemia for inhabitants of northeastern Iran. Afshari, R; Dadsetan, A; Hami, S; Mahmudy Gharaie, MH; Mehrzad, J; Taheri, M, 2016) | 0.43 |
| "Previous studies have established in vivo-in vitro correlations (IVIVC) between arsenic (As) relative bioavailability (RBA) and bioaccessibility in contaminated soils." | ( In vitro bioaccessibility and in vivo relative bioavailability in 12 contaminated soils: Method comparison and method development. Basta, NT; Cui, XY; Li, HB; Li, J; Li, K; Li, LP; Ma, LQ, 2015) | 0.42 |
| " In the present study, a multi-unit drug delivery system (MUDDS) for a Chinese medicine Niuhuang Xingxiao Wan (NXW) was prepared using micro/nanotechnologies to enhance the bioavailability and efficacy." | ( Preparation of a micro/nanotechnology based multi-unit drug delivery system for a Chinese medicine Niuhuang Xingxiao Wan and assessment of its antitumor efficacy. Feng, N; Guo, T; Shi, F; Yang, G; Zhang, Y, 2015) | 0.42 |
| " Arsenic relative bioavailability (RBA) in soil is known to be variable; the extent and role of iAs bioavailability in food are not well characterized." | ( Arsenic relative bioavailability from diet and airborne exposures: Implications for risk assessment. Greene, T; Schoof, RA; Yager, JW, 2015) | 0.42 |
| "In this study, previously established arsenic (As) in vivo-in vitro correlations (IVIVC) were assessed for their validity using an independent data set comprising As relative bioavailability (RBA) and bioaccessibility values for 13 herbicide- and mine-impacted soils." | ( Predicting Arsenic Relative Bioavailability Using Multiple in Vitro Assays: Validation of in Vivo-in Vitro Correlations. Boland, J; Herde, C; Herde, P; Juhasz, AL; Smith, E, 2015) | 0.42 |
| "The effects of aging time and soil parent materials on the bioavailability and fractionations of arsenic (As) in five red soils were studied." | ( Effect of aging on the bioavailability and fractionation of arsenic in soils derived from five parent materials in a red soil region of Southern China. Bai, L; Li, L; Lu, Y; Su, S; Wang, Y; Wu, C; Zeng, X, 2015) | 0.42 |
| " The objective of this study was to examine the speciation and bioavailability of lead (Pb) in selected complementary medicines." | ( Speciation and bioavailability of lead in complementary medicines. Bolan, S; Clark, I; Dong, M; Kunhikrishnan, A; Naidu, R; Ok, YS; Palanisami, T; Seshadri, B, 2016) | 0.43 |
| "The precise evaluation of arsenic (As) and mercury (Hg) bioavailability in sediment is crucial to controlling As and Hg contamination, but traditional ex situ measurements hamper comprehensive analysis of labile As and Hg in sediment." | ( In situ high-resolution evaluation of labile arsenic and mercury in sediment of a large shallow lake. Fan, X; Hou, J; Qian, J; Wang, C; Wang, P; Yao, Y; Yuan, Y, 2016) | 0.43 |
| "We investigated the quantification of bioavailable arsenic in contaminated soils and evaluation of soil-washing processes in the aspect of bioavailability using a novel bacterial bioreporter developed in present study." | ( Arsenic bioavailability in soils before and after soil washing: the use of Escherichia coli whole-cell bioreporters. An, YJ; Chae, Y; Jeong, SW; Kang, Y; Kim, S; Lee, Y; Yoon, Y, 2016) | 0.43 |
| " The in vivo bioavailability of Pb decreased in the phosphate treatment relative to the untreated soil (6 and 24%, respectively), and also in the Fe WTR 2% (12%) and nZVI-2 (13%) treatments." | ( In Situ Fixation of Metal(loid)s in Contaminated Soils: A Comparison of Conventional, Opportunistic, and Engineered Soil Amendments. Betts, AR; Brunetti, G; Castaldi, P; Deiana, S; Donner, E; Juhasz, AL; Lombi, E; Mele, E; Scheckel, KG; Smith, E, 2015) | 0.42 |
| " Moreover, the identification of the bioavailability of selected carcinogenic and toxic elements in the future might be used as output data for potential biological and population research on risk assessment." | ( Trace Elements Speciation of Submicron Particulate Matter (PM1) Collected in the Surroundings of Power Plants. Kaczmarek, K; Mainka, A; Zajusz-Zubek, E, 2015) | 0.42 |
| "Although rice cultivated under water-saturated conditions as opposed to submerged conditions has received considerable attention with regard to reducing As levels in rice grain, the rhizosphere microbiome potentially influencing As-biotransformation and bioavailability in a rice ecosystem has rarely been studied." | ( Water management impacts on arsenic behavior and rhizosphere bacterial communities and activities in a rice agro-ecosystem. Chou, ML; Das, S; Jean, JS; Liu, CC; Yang, HJ, 2016) | 0.43 |
| " Bioavailability of metals in sediment did not always result in accumulation in muscle tissue." | ( Heavy metals in red crabs, Chaceon quinquedens, from the Gulf of Mexico. Isphording, W; Perry, H; Riedel, R; Trigg, C, 2015) | 0.42 |
| "Different animals and biomarkers have been used to measure the relative bioavailability of arsenic (As-RBA) in contaminated soils." | ( Arsenic Relative Bioavailability in Contaminated Soils: Comparison of Animal Models, Dosing Schemes, and Biological End Points. Juhasz, AL; Li, C; Li, HB; Li, J; Luo, J; Ma, LQ; Sun, HJ, 2016) | 0.43 |
| " The impact of the 2011 PCCVC eruption on the As levels of biota was more evident in pelagic-associated organisms (zooplankton and planktivorous fish), but only in the short term, suggesting a brief high bioavailability of As in water after ash deposition." | ( Natural origin arsenic in aquatic organisms from a deep oligotrophic lake under the influence of volcanic eruptions. Arcagni, M; Arribére, M; Campbell, L; Guevara, SR; Juncos, R; Rizzo, A, 2016) | 0.43 |
| "The mobility and bioavailability of arsenic (As) are strongly controlled by adsorption/precipitation processes involving metal oxides." | ( Interaction of arsenic species with tropical river aquatic humic substances enriched with aluminum and iron. de Oliveira, LK; Fraceto, LF; Friese, K; Melo, Cde A; Rosa, AH, 2016) | 0.43 |
| " We thus believe that As in the studied area was with low mobility and bioavailability in sediment, agricultural soils, and non-agricultural soils." | ( The concentration and chemical speciation of arsenic in the Nanpan River, the upstream of the Pearl River, China. Pan, B; Wei, R; Yang, B; Yang, S; Zhao, N; Zhou, D, 2016) | 0.43 |
| " The elevated bioavailability and bioaccumulation of Pb, As and Cs in paddy soil under an electro-kinetic field (EKF) were studied." | ( Electro-kinetic remediation coupled with phytoremediation to remove lead, arsenic and cesium from contaminated paddy soil. Arslan, Z; Guo, K; Han, FX; Mao, X; McComb, J; Shao, X; Zhang, Z, 2016) | 0.43 |
| " The use of both species is proposed to monitor the bioavailability and oxidative damage in coastal areas with mining activity." | ( Assessment oxidative stress biomarkers and metal bioaccumulation in macroalgae from coastal areas with mining activities in Chile. Carrasco Kittelsen, R; Gaete Olivares, H; Hidalgo Lillo, ME; Jara Gutierrez, C; Lobos Valenzuela, G; Moyano Lagos, N, 2016) | 0.43 |
| " The results indicate that As bioavailability is negligible." | ( Strong Acid Mixture and Sequential Geochemical Arsenic Extractions in Surface Sediments from the Santa Maria La Reforma Coastal Lagoon, Mexico: A Bioavailability Assessment. Green-Ruiz, C; Rivera-Hernández, JR, 2016) | 0.43 |
| " Here we report a novel strategy for testing arsenic (As) bioavailability in soil samples by direct (in vivo) and indirect (in vitro) measurement using an Escherichia coli-based whole-cell bioreporter (WCB)." | ( Evaluation of bioavailable arsenic and remediation performance using a whole-cell bioreporter. An, YJ; Chae, Y; Jeong, SW; Kim, S; Yoon, Y, 2016) | 0.43 |
| "Traditional Chinese medicines (TCM) are increasingly being used as alternative medicines in many countries, and this has caused concern because of adverse health effects from toxic metal bioavailability such as mercury (Hg) and arsenic (As)." | ( Bioavailability study of arsenic and mercury in traditional Chinese medicines (TCM) using an animal model after a single dose exposure. Ng, J; Noller, B; Sadler, R; Seawright, A; Tinggi, U, 2016) | 0.43 |
| "Dietary uptake could be the primary route of arsenic (As) bioaccumulation in marine fish, but the bioavailability of inorganic and organic As remains elusive." | ( Comparison of Bioavailability and Biotransformation of Inorganic and Organic Arsenic to Two Marine Fish. Wang, WX; Zhang, L; Zhang, W, 2016) | 0.43 |
| " More importantly, biochar stimulated the DOM bioavailability in association with bacterial activities mediating As(V) and Fe(III) reduction." | ( Enhanced bioreduction of iron and arsenic in sediment by biochar amendment influencing microbial community composition and dissolved organic matter content and composition. Chen, Z; Fu, D; Jiang, X; Li, QB; Shen, L; Wang, H; Wang, Y; Xia, D, 2016) | 0.43 |
| " To evaluate BCs effect on Cd, Pb, As bioavailability and mobility, CaCl2, KH2PO4 and SPLP extractions were firstly carried out." | ( Varying effect of biochar on Cd, Pb and As mobility in a multi-metal contaminated paddy soil. Chen, C; Li, H; Peng, B; Tan, C; Wang, X; Yin, D, 2016) | 0.43 |
| " The sequential extraction of As indicated that the metalloid in these soils has a high bioavailability (38 %), which is attributed to the alkaline pH, low organic matter and Fe oxide content, and sandy texture." | ( Phytostabilization of arsenic in soils with plants of the genus Atriplex established in situ in the Atacama Desert. Acuña, E; Casanova, M; Diaz, O; Fernández, YT; Masaguer, A; Salazar, O, 2016) | 0.43 |
| "Several investigations have been conducted to develop in vitro bioaccessibility (IVBA) assays that reliably predict in vivo oral relative bioavailability (RBA) of arsenic (As)." | ( Predicting oral relative bioavailability of arsenic in soil from in vitro bioaccessibility. Bradham, KD; Brattin, WJ; Burgess, M; Diamond, GL; Griffin, S; Hawkins, CA; Juhasz, AL; Klotzbach, JM; Lowney, YW; Nelson, C; Scheckel, KG; Thomas, DJ, 2016) | 0.43 |
| " Our hypothesis was that the sequestering agents used in active caps and in situ treatment will bind elements (arsenic, chromium, cadmium, cobalt, copper, nickel, lead, selenium, and zinc) from ongoing sources thereby reducing their bioavailability and protecting underlying remediated sediments from recontamination." | ( Environmental impact of ongoing sources of metal contamination on remediated sediments. Knox, AS; Milliken, CE; Paller, MH; Redder, TM; Seaman, J; Wolfe, JR, 2016) | 0.43 |
| " Subsequently, exposure is calculated by the quantification of the following factors: hand loading, soil-mouth transfer effectivity, hand-mouth contact frequency, contact surface, body weight and the relative oral bioavailability factor." | ( Assessment of health risks due to arsenic from iron ore lumps in a beach setting. Janssen, PJ; Swartjes, FA, 2016) | 0.43 |
| " It was determined that soil washing agents and their washing order were critical to removal efficiencies of metal fractions, metal bioavailability and potential mobility due to different levels of dissolution of residual fractions and inter-transformation of metal fractions." | ( Removal of arsenic and cadmium with sequential soil washing techniques using Na2EDTA, oxalic and phosphoric acid: Optimization conditions, removal effectiveness and ecological risks. Chen, J; Wang, X; Wei, M, 2016) | 0.43 |
| " We investigated whether crushing realgar crystals to the nanoscale and encapsulating the particles in a water-soluble polymer in one step using hot-melt extrusion would increase the bioavailability of As4S4." | ( Fabrication of water-soluble polymer-encapsulated As4S4 to increase oral bioavailability and chemotherapeutic efficacy in AML mice. Guo, H; Li, X; Liu, J; Ma, Q; Meng, J; Wang, C; Xu, H, 2016) | 0.43 |
| " Nano-TiO2 dispersion could, however, interact with metals and modify their behavior and bioavailability in aquatic environments." | ( Arsenate Accumulation, Distribution, and Toxicity Associated with Titanium Dioxide Nanoparticles in Daphnia magna. Chi, Q; Li, M; Luo, Z; Wang, Z; Xing, B; Yan, C; Yan, Y, 2016) | 0.43 |
| "In this work, the effects of various wastewater sources (storm water, sewage effluent, piggery effluent, and dairy effluent) on the reduction, and subsequent mobility and bioavailability of arsenate [As(V)] and chromate [Cr(VI)] were compared using both spiked and field contaminated soils." | ( Impact of wastewater derived dissolved organic carbon on reduction, mobility, and bioavailability of As(V) and Cr(VI) in contaminated soils. Bolan, NS; Choppala, G; Kim, WI; Kunhikrishnan, A; Mbene, K; Seshadri, B; Wijesekara, H, 2017) | 0.46 |
| " Irrigation with As contaminated groundwater in rice fields increases As concentration in topsoil and its bioavailability for rice crops." | ( Factors affecting the soil arsenic bioavailability, accumulation in rice and risk to human health: a review. Azam, SM; Naz, S; Sarker, TC, 2016) | 0.43 |
| " We studied the distribution, mobility and bioavailability of Al, As and Fe in natural waters of a mining area (Quadrilátero Ferrífero, Brazil) and the influence of organic matter in these processes." | ( Distribution and bioavailability of arsenic in natural waters of a mining area studied by ultrafiltration and diffusive gradients in thin films. da Silva, GA; Friese, K; Gontijo, ES; Monteiro, AS; Roeser, HM; Rosa, AH; Tonello, PS; Watanabe, CH, 2016) | 0.43 |
| "The bioavailability and risk assessment of As were studied in sediments of the Yangtze River estuary (YRE)." | ( Bioavailability and risk assessment of arsenic in surface sediments of the Yangtze River estuary. Liu, R; Men, C; Shen, Z; Wang, H; Wang, Q; Xu, F, 2016) | 0.43 |
| " Under these conditions the bioavailability of As is greatly enhanced leading to excessive As bioaccumulation compared to that under oxidizing upland conditions." | ( Arsenic accumulation in rice: Consequences of rice genotypes and management practices to reduce human health risk. Islam, MR; Islam, S; Naidu, R; Rahman, MM, 2016) | 0.43 |
| " The bioavailability and metabolism of green tea and its protective effects against environmental insults induced by pesticides, smoke, mycotoxins, PCBs, and arsenic are reviewed in this paper." | ( Therapeutic properties of green tea against environmental insults. Chen, L; Cromie, MM; Gao, W; Lu, C; Mo, H; Shen, CL; Wang, JS; Wang, S; Zhao, L, 2017) | 0.46 |
| " For example, our analyses showed that earthworms decreased pH and increased bioavailability for both arsenic and iron as demonstrated by increases in leachate and plant tissue concentrations." | ( The influence of hydrous ferric oxide, earthworms, and a hypertolerant plant on arsenic and iron bioavailability, fate, and transport in soils. Ford, SC; Hodges, KR; Maki, BC; Sofield, RM, 2017) | 0.46 |
| " However, studies on the bioavailability of Rox in humans are scarce." | ( Accumulation and Transport of Roxarsone, Arsenobetaine, and Inorganic Arsenic Using the Human Immortalized Caco-2 Cell Line. Le, XC; Leslie, EM; Liu, Q, 2016) | 0.43 |
| " The strains were characterized for their production of indole-3-acetic acid (IAA) and siderophores, their effects on soil metal(loid) bioavailability and organic matter content, and their effects on the edible tissue growth and metal(loid) accumulation of Chinese cabbage and radish in the metal(loid)-contaminated soil." | ( Isolation of As-tolerant bacteria and their potentials of reducing As and Cd accumulation of edible tissues of vegetables in metal(loid)-contaminated soils. He, L; Nie, Z; Sheng, X; Wang, Q; Wang, X, 2017) | 0.46 |
| " Furthermore, the bioavailability of As, Cd, and lead (Pb) in mice after 20-day oral ingestion of Crassostrea rivularis was investigated, and the total rate of absorption of toxic elements in samples from the liver and kidney tissues and blood was determined." | ( Distribution of As, Cd, and Pb in seafood in Southern China and their oral bioavailability in mice. Tang, WY; Tong, YP; Wu, ZB; Wu, ZX; Zhu, ZP, 2017) | 0.46 |
| " However, large dose of realgar and long period of treatment are necessary for achieving the effective blood medicine concentration due to its low bioavailability resulted from poor solubility." | ( Realgar transforming solution displays anticancer potential against human hepatocellular carcinoma HepG2 cells by inducing ROS. Chen, P; Cui, P; Duan, Z; Gao, Q; Li, H; Li, Y; Song, P; Wang, A; Wang, D; Wang, X; Wang, Y; Wu, Z; Zhao, L; Zhu, R; Zhu, S, 2017) | 0.46 |
| "Bio-accessibility and bioavailability of arsenic (As) in historically As-contaminated soils (cattle tick pesticide), and pristine soils were assessed using 3 different approaches." | ( Arsenic bio-accessibility and bioaccumulation in aged pesticide contaminated soils: A multiline investigation to understand environmental risk. Clark, MW; Farzana, T; Rahman, MS; Reichelt-Brushet, AJ; Yee, LH, 2017) | 0.46 |
| " The findings will stimulate more studies on the biosynthesis of complex organoarsenicals, and lead to a better understanding of the bioavailability and function of the organoarsenicals in biological systems." | ( Arsenic Methyltransferase is Involved in Arsenosugar Biosynthesis by Providing DMA. Francesconi, KA; Gao, H; Li, G; Raber, G; Rensing, C; Xue, XM; Yan, Y; Ye, J; Zhu, YG, 2017) | 0.46 |
| "Regulators ( = 14) and the public ( = 30) were surveyed to compare how they perceived contaminated soil management strategies, including bioavailability assessments, using a mental models approach." | ( Evaluating Public and Regulatory Acceptance for Urban Soil Management Approaches. Basta, NT; Obrycki, JF; Wilson, RS, 2017) | 0.46 |
| "Iron (Fe)-based solids can reduce arsenic (As) mobility and bioavailability in soils, which has been well recognized." | ( Arsenic mobility and bioavailability in paddy soil under iron compound amendments at different growth stages of rice. Lei, J; Li, B; Li, F; Liu, C; Wang, Q; Wang, X; Yu, HY, 2017) | 0.46 |
| " Overall, the application of chemical amendments could be utilized for decreasing PTE (As and Cd) bioavailability and increasing microbial activity in the soil." | ( Effect of chemical amendments on remediation of potentially toxic trace elements (PTEs) and soil quality improvement in paddy fields. Hong, YK; Kim, DH; Kim, SC; Lee, SP; Oh, SJ; Oh, SM; Yang, JE, 2017) | 0.46 |
| " Dissolved As species, together with total and particulate As, were used to evaluate the potential bioavailability of As in water as well as to decipher inputs from natural geological processes and ABS mining and upgrading activities." | ( Arsenic speciation in the lower Athabasca River watershed: A geochemical investigation of the dissolved and particulate phases. Donner, MW; Francesconi, KA; Javed, MB; Shotyk, W; Siddique, T, 2017) | 0.46 |
| "Reactive mineral-water interfaces exert control on the bioavailability of contaminant arsenic species in natural aqueous systems." | ( Structures and Properties of As(OH) de Leeuw, NH; Dzade, NY; Roldan, A, 2017) | 0.46 |
| "A steady-state mouse model was developed to determine arsenic (As) relative bioavailability (RBA) in rice to refine As exposure in humans." | ( Arsenic Relative Bioavailability in Rice Using a Mouse Arsenic Urinary Excretion Bioassay and Its Application to Assess Human Health Risk. Juhasz, AL; Li, C; Li, HB; Li, J; Ma, LQ; Sun, HJ; Wang, XJ; Zhao, D, 2017) | 0.46 |
| "In this study, the influence of sample matrix on the relative bioavailability of arsenic (As), cadmium (Cd) and lead (Pb) was assessed following exposure of C57BL/6 mice to spiked aged (12years) soils." | ( Influence of sample matrix on the bioavailability of arsenic, cadmium and lead during co-contaminant exposure. Herde, P; Juhasz, AL; Ollson, CJ; Smith, E, 2017) | 0.46 |
| " The objective of this study was to determine the effect of Si-treated calcium metallurgical slag and battery slag on the As, Se, Cd, Pb, Ni, Cr, and Hg mobility and bioavailability in mine tailings (Xikuangshan mine, Hunan, China)." | ( Si-based technologies for reduction of the pollutant leaching from landfills and mine tails. Bocharnikova, E; Jiang, J; Matichenkov, V; Yuejin, C, 2017) | 0.46 |
| " Despite this, metabolic capabilities of only a few DARB strains have been thoroughly investigated so far, and the influence of these bacteria on the bioavailability of arsenic in the environment is still a topic for discussion." | ( The role of dissimilatory arsenate reducing bacteria in the biogeochemical cycle of arsenic based on the physiological and functional analysis of Aeromonas sp. O23A. Debiec, K; Drewniak, L; Sklodowska, A; Uhrynowski, W, 2017) | 0.46 |
| "An in vivo assay using swine was used to measure the absolute bioavailability (AB) of As from cooked rice of twelve genotypes commonly grown in Bangladesh." | ( Variation in arsenic bioavailability in rice genotypes using swine model: An animal study. Duan, L; Islam, MR; Islam, S; Kuchel, T; Naidu, R; Rahman, MM, 2017) | 0.46 |
| "To our knowledge, this is the first report on exploring the interactive effects of various biochars (BCs) and nanomaterials (NMs) on plant growth and bioavailability of trace elements in soil." | ( Potential toxicity of trace elements and nanomaterials to Chinese cabbage in arsenic- and lead-contaminated soil amended with biochars. Awad, YM; Lee, SS; Niazi, NK; Ok, YS; Rinklebe, J; Rizwan, M; Vithanage, M; Yang, JE, 2019) | 0.51 |
| " Microbial redox metabolism of iron, carbon, sulfur, and nitrogen affects the redox and bioavailability of arsenic species." | ( Linking Genes to Microbial Biogeochemical Cycling: Lessons from Arsenic. Kappler, A; Meharg, AA; Rosen, BP; Xue, XM; Zhu, YG, 2017) | 0.46 |
| " To reduce soil Pb risk to humans by oral exposure, phosphate amendments have been used to reduce Pb relative bioavailability (RBA), but its efficiency has not been investigated using validated in vitro assays nor its influence on As-RBA." | ( Effect of phosphate amendment on relative bioavailability and bioaccessibility of lead and arsenic in contaminated soils. Li, HB; Li, MY; Li, SW; Liu, X; Luo, J; Ma, LQ; Sun, HJ; Zhao, D, 2017) | 0.46 |
| " Results indicated that amendments of PNB and SSB increased plant biomass production by increasing soil fertility and reducing bioavailability of PTEs." | ( Biochars mitigate greenhouse gas emissions and bioaccumulation of potentially toxic elements and arsenic speciation in Phaseolus vulgaris L. Chi, Q; Ibrahim, M; Khan, S; Li, G; Xu, Y; Zhu, Y, 2017) | 0.46 |
| " survived in the rhizosphere and improved soil As bioavailability with co-exposure." | ( Interactions between Pteris vittata L. genotypes and a polycyclic aromatic hydrocarbon (PAH)-degrading bacterium (Alcaligenes sp.) in arsenic uptake and PAH-dissipation. Liao, X; Sun, L; Yan, X; Zhu, G, 2017) | 0.46 |
| " Its bioavailability has varied dramatically over the history of life on Earth." | ( Recurrent horizontal transfer of arsenite methyltransferase genes facilitated adaptation of life to arsenic. Chen, SC; Deng, Y; Rensing, C; Rosen, BP; Sun, GX; Zhang, SY; Zhu, BK; Zhu, YG, 2017) | 0.46 |
| " The importance of determining bioavailability towards human health risk assessment was emphasized by the need to estimate daily intake of heavy metal(loid)s in complementary medicines." | ( Sources, distribution, bioavailability, toxicity, and risk assessment of heavy metal(loid)s in complementary medicines. Bolan, NS; Bolan, S; Choppala, G; Kirkham, MB; Kunhikrishnan, A; Li, CG; Li, F; Naidu, R; Noller, B; Ok, YS; Seshadri, B; Zhang, M, 2017) | 0.46 |
| " To gain new insights into the effects of P on As mobility, speciation, and bioavailability in wetlands, well-controlled greenhouse experiments were conducted." | ( Phosphate enhanced abiotic and biotic arsenic mobilization in the wetland rhizosphere. Jaffé, PR; Moon, HS; Myneni, SCB; Zhang, Z, 2017) | 0.46 |
| "Although specific soil properties controlling the arsenic (As) aging process have been studied extensively, few investigations have attempted to determine how soil types influence As bioavailability and fractionations in soils." | ( Dynamic arsenic aging processes and their mechanisms in nine types of Chinese soils. Bai, L; Lu, Y; Su, S; Wang, Y; Wu, C; Zeng, X, 2017) | 0.46 |
| " The aim of this study was to determine the effect of organic matter removal by thermal transformation (roasting) on the bioavailability of BIOs and their arsenic sorption capacity." | ( The influence of thermal treatment on bioweathering and arsenic sorption capacity of a natural iron (oxyhydr)oxide-based adsorbent. Bajda, T; Debiec, K; Drewniak, L; Krzysztoforski, J; Rzepa, G; Sklodowska, A; Zych, L, 2017) | 0.46 |
| "Several predictive models and methods have been used for heavy metals bioavailability, but there is no universally accepted approach in evaluating the bioavailability of arsenic (As) in soil." | ( Comparison of DGT with traditional extraction methods for assessing arsenic bioavailability to Brassica chinensis in different soils. Dai, Y; Gao, J; Lv, J; Lv, Y; Nasir, M; Zhang, Y, 2018) | 0.48 |
| " Our findings indicated that lactate and biochar in flooded paddy soils can stimulate the active As(V)-respiring bacteria Geobacter species for arsenic reduction and release, which probably increases arsenic bioavailability to rice plants." | ( Transcriptional Activity of Arsenic-Reducing Bacteria and Genes Regulated by Lactate and Biochar during Arsenic Transformation in Flooded Paddy Soil. Cui, JH; Hu, M; Huang, W; Li, FB; Li, XM; Qiao, JT; Sun, WM; Young, LY, 2018) | 0.48 |
| " In this study, the impacts of zero valent iron (ZVI) and/or biochar amendments on Cd and As bioavailability were examined in pot trials with rice." | ( Simultaneous alleviation of cadmium and arsenic accumulation in rice by applying zero-valent iron and biochar to contaminated paddy soils. Cui, JH; Li, FB; Liu, CP; Liu, TX; Lv, YH; Qiao, JT; Wang, XQ; Yuan, YZ; Zeng, XD, 2018) | 0.48 |
| " The results suggest that using the more relevant <150-μm fraction will not undermine currently validated IVBA protocols in future bioavailability studies." | ( Lead and Arsenic Bioaccessibility and Speciation as a Function of Soil Particle Size. Betts, AR; Karna, RR; Noerpel, M; Scheckel, KG, 2017) | 0.46 |
| " This may have important implications for the potential bioavailability of these contaminants, as well as for the use of this water for human consumption." | ( Iron oxide - clay composite vectors on long-distance transport of arsenic and toxic metals in mining-affected areas. Bolea, E; Garcia-Guinea, J; Garrido, F; Gomez-Gonzalez, MA; Laborda, F; Marco, JF; Villalobos, M, 2018) | 0.48 |
| " Stirred-flow desorption studies and in vitro physiologically based extractions were used to assess the mobility and relative bioavailability of soil As, respectively." | ( Arsenic Speciation and Availability in Orchard Soils Historically Contaminated with Lead Arsenate. Gamble, AV; Givens, AK; Sparks, DL, 2018) | 0.48 |
| " Seasonal, tidal, marine, riverine, and terrestrial components are seen to influence occurrence, speciation, bioavailability and fate of metals in these ecosystems." | ( Metals in mangrove ecosystems and associated biota: A global perspective. Deobagkar, D; Kulkarni, R; Zinjarde, S, 2018) | 0.48 |
| " Therefore, fractionation studies in residues and soils are required to analyze the mobility and bioavailability of this metal, which in turn provide information to infer its speciation." | ( Fractionation and mobility of thallium in areas impacted by mining-metallurgical activities: Identification of a water-soluble Tl(I) fraction. Cruz-Hernández, Y; Garrido, F; Hernández-Alvarez, E; Meza-Figueroa, D; Pi-Puig, T; Romero, FM; Ruiz-García, M; Villalobos, M, 2018) | 0.48 |
| "001) reduced the bioavailability of TM concentrations in amended soil and increased pea and chili plants' and fruits' biomasses when compared with the control." | ( Minimizing the risk to human health due to the ingestion of arsenic and toxic metals in vegetables by the application of biochar, farmyard manure and peat moss. Ghani, J; Khan, S; Nawab, J; Xiaoping, W, 2018) | 0.48 |
| " Arsenic bioavailability varies among soils and is influenced by site-specific soil physical and chemical characteristics and internal biological factors." | ( In vivo and in vitro methods for evaluating soil arsenic bioavailability: relevant to human health risk assessment. Bradham, KD; Burgess, M; Diamond, GL; Juhasz, A; Klotzbach, JM; Maddaloni, M; Nelson, C; Scheckel, K; Serda, SM; Stifelman, M; Thomas, DJ, 2018) | 0.48 |
| " It was highlighted that although heavy metals particularly Pb and Zn tended to accumulate in solid residues with a maximum increment of about 50% in the total content, they were mostly converted to more stable oxidizable and residual fractions, and thus the ecotoxicity and bioavailability were greatly mitigated with no obvious increase in direct toxicity fractions." | ( Supercritical water treatment of heavy metal and arsenic metalloid-bioaccumulating-biomass. Chen, J; Chen, S; Li, J, 2018) | 0.48 |
| " For both As and Sb, bioavailable concentrations increased proportionally with the total soil concentrations and greater bioavailability in recently contaminated soil was observed." | ( As and Sb are more labile and toxic to water spinach (Ipomoea aquatica) in recently contaminated soils than historically co-contaminated soils. Egodawatta, LP; Jolley, DF; Macoustra, GK; Ngo, LK, 2018) | 0.48 |
| "Chronic exposure to arsenic (As) is a global concern due to worldwide exposure and adverse effects, and the importance of incorporating bioavailability in the exposure assessment and risk assessment of As is increasing acknowledged." | ( A Pooled Data Analysis to Determine the Relationship between Selected Metals and Arsenic Bioavailability in Soil. Dong, Z; Duan, L; Liu, Y; Naidu, R; Wijayawardena, A; Yan, K, 2018) | 0.48 |
| "An incubation test was conducted to study the bioavailability and fractionations of exogenous arsenite [As(3)] during the aging period in three soils originated from different parent materials, including quaternary red clay, purple sandy shale and granite." | ( [Aging process of arsenite [As(3)]in soils originated from different parent materials.] Bai, LY; Gao, X; Su, SM; Wang, YN; Wu, CX; Zeng, XB, 2016) | 0.43 |
| " We applied an Escherichia coli-based bioreporter to assess the bioavailability of As(v) adsorbed by goethite (α-FeOOH), 2-line ferrihydrite and As(v) co-precipitated with Fe(iii)." | ( Bacterial bioreporter detection of arsenic associated with iron oxides. Finger, A; Peña, J; van der Meer, JR; van Genuchten, CM, 2018) | 0.48 |
| " The bioavailability of arsenic is influenced by its behavior, in particular its adsorption-desorption in the soil environment." | ( Using Q He, W; Liu, Y; Lu, G; Naidu, R; Tian, H; Wang, Z, 2018) | 0.48 |
| " Nevertheless, in soils polluted by potentially toxic metal(loid)s, this agricultural practice may significantly affect the mobility and bioavailability of pollutants modifying the risks for biota and human health." | ( Impact of waste-derived organic and inorganic amendments on the mobility and bioavailability of arsenic and cadmium in alkaline and acid soils. Adamo, P; Bolan, NS; Mbene, K; Naidu, R; Rocco, C; Seshadri, B, 2018) | 0.48 |
| " The relationship between arsenic bioavailability in gastric, small intestinal phases and arsenic speciation was also studied." | ( [Effect of Different Iron Minerals on Bioaccessibility of Soil Arsenic Using Chen, ZL; He, HF; Huang, RL; Lin, QT; Wang, WK; Yin, GC; Zhong, SX, 2017) | 0.46 |
| "Arsenic exists in the form of various chemical species differing in their physicochemical behavior, toxicity, bioavailability and biotransformation." | ( Speciation of Arsenic in Ground Water Samples by Ion Exchange Chromatography with Improved Sample Preparation Technique. A, S; Selvaraj, J; Shanmugam, T, 2018) | 0.48 |
| " The 7-day wheat seed germination toxicity test was then used to assess the bioavailability of toxicants in aqueous leachates of the biochar-amended tailing samples." | ( Arundo donax L. stem-derived biochar increases As and Sb toxicities from nonferrous metal mine tailings. Gu, J; Jordan, G; Li, H; Lu, C; Min, N; Roha, B; Yao, J, 2020) | 0.56 |
| "Manganese oxides are naturally occurring powerful oxidants and scavengers, which can control the mobility and bioavailability of arsenic (As)." | ( Mitigating arsenic accumulation in rice (Oryza sativa L.) from typical arsenic contaminated paddy soil of southern China using nanostructured α-MnO Lei, M; Li, B; Long, J; Peng, L; Tie, B; Wei, D; Williams, PN; Zhou, S, 2019) | 0.51 |
| "Biochar, produced by the pyrolysis of biomass under low oxygen conditions, has gathered attention in the last few years due to its capability to reduce metal(loid)s bioavailability and mobility in soils, as well as its beneficial effects on soil fertility." | ( Effect of Fe-functionalized biochar on toxicity of a technosol contaminated by Pb and As: sorption and phytotoxicity tests. Bourgerie, S; Lebrun, M; Miard, F; Morabito, D; Nandillon, R; Renouard, S; Scippa, GS, 2018) | 0.48 |
| " However, bioavailable Cu did not significantly correlate with CISED identified soil phases, suggesting that sequential extraction schemes such as CISED may not be ideally suited for inferring bioavailability to microorganisms in soil and supports the integration of receptor-specific bioavailability tests into risk assessments as a complement to chemical methods." | ( Factors governing the solid phase distribution of Cr, Cu and As in contaminated soil after 40 years of ageing. Brandt, KK; Cave, M; Cipullo, S; Coulon, F; Holm, PE; Sø, HU; Tardif, S; Wragg, J, 2019) | 0.51 |
| " Growing environment of rice typically attributed by geographical origin may influence on arsenic bioavailability in rice grain." | ( Geographical variation of arsenic distribution in paddy soil, rice and rice-based products: A meta-analytic approach and implications to human health. Banik, P; Majumder, S, 2019) | 0.51 |
| " This review analyse papers from 2004 to 2017 on As in fresh fish and molluscs caught in the Mediterranean sea and the European coast of the Atlantic ocean allowing the identification of the marine area with a greater As bioavailability and in particular the identification of the European populations more exposed to In-As by consuming fresh seafood." | ( Systematic review of arsenic in fresh seafood from the Mediterranean Sea and European Atlantic coasts: A health risk assessment. Copat, C; Cristaldi, A; Ferrante, M; Grasso, A; Napoli, S; Zuccarello, P, 2019) | 0.51 |
| "The bioavailability of the metalloid arsenic (As) in paddy soil is controlled by microbial cycling of As and other elements such as iron (Fe) and sulfur (S), which are strongly influenced by water management in paddy fields." | ( Water management impacts the soil microbial communities and total arsenic and methylated arsenicals in rice grains. Chen, XP; Tang, Z; Wang, M; Wang, X; Zhang, J; Zhao, FJ; Zhou, WX, 2019) | 0.51 |
| " The study focused on the identification of indigenous metallophytes thriving in the area as well as the bioavailability of Cu and As in soils and its implication to the growth of the indigenous plants." | ( The identification of indigenous Cu and As metallophytes in the Lepanto Cu-Au Mine, Luzon, Philippines. Algo, JLC; Claveria, RJR; Perez, REC; Perez, TR; Robles, PQ, 2019) | 0.51 |
| " While the exposure profiles of As(III) and As(V) are quite similar, the absorption rate of As(V) is relatively higher than that of As(III)." | ( The Bioaccumulation and Tissue Distribution of Arsenic Species in Tilapia. Fan, W; Liu, L; Pei, J; Wang, X; Yin, J; Zuo, J, 2019) | 0.51 |
| " The bioelectricity production process affected the bioavailability of arsenic and heavy metals in the sediment and attenuated metal uptake by plants, which indicated the potential for remediation of arsenic and heavy metals pollution in sediment." | ( Bioelectricity generation by wetland plant-sediment microbial fuel cells (P-SMFC) and effects on the transformation and mobility of arsenic and heavy metals in sediment. Dahlgren, RA; Feng, C; Zhang, T; Zhou, S; Zhu, J; Zhu, N, 2019) | 0.51 |
| " Speciation analysis has become increasingly important in making risk assessments of toxic elements since the toxicity and bioavailability strongly depend on their chemical forms." | ( Speciation Analysis of Trace Arsenic, Mercury, Selenium and Antimony in Environmental and Biological Samples Based on Hyphenated Techniques. Deng, T; Guo, Y; Liu, C; Yu, X, 2019) | 0.51 |
| "Arsenic biotransformation mediated by gut microbiota can affect arsenic bioavailability and microbial community." | ( Effects of Arsenic on Gut Microbiota and Its Biotransformation Genes in Earthworm Metaphire sieboldi. Ding, J; Li, G; O'Connor, PJ; Wang, HT; Xue, XM; Zheng, F; Zhu, D; Zhu, YG, 2019) | 0.51 |
| " Bioaccumulation and exposure to these elements have been associated with different types of diseases and cancer, thus looking for alternatives that decrease their bioavailability in the environment is crucial." | ( Metal and metalloid immobilization by microbiologically induced carbonates precipitation. Brandão, PFB; Castillo, E; Tamayo-Figueroa, DP, 2019) | 0.51 |
| "This study was conducted to determine the effects of rice husk ash (RHA) and Fe-coated rice husk ash (Fe-RHA) on the bioavailability and mobility of As, Cd, and Mn in mine tailings." | ( Bioavailability and mobility of arsenic, cadmium, and manganese in gold mine tailings amended with rice husk ash and Fe-coated rice husk ash. Aris, AZ; Jamilu, G; Karam, DS; Samsuri, AW; Tariq, FS, 2019) | 0.51 |
| "The aim of this study was to determine the bioavailability of metals in field soils contaminated with chromated copper arsenate (CCA) mixtures." | ( An uptake and elimination kinetics approach to assess the bioavailability of chromium, copper, and arsenic to earthworms (Eisenia andrei) in contaminated field soils. Kilpi-Koski, J; Penttinen, OP; Väisänen, AO; van Gestel, CAM, 2019) | 0.51 |
| " The changes in irrigation conditions may alter the oxidation states of Sb and As, which influences their mobility and bioavailability and hence uptake by rice." | ( Bacterial response to antimony and arsenic contamination in rice paddies during different flooding conditions. Häggblom, MM; Han, F; Li, B; Li, F; Sun, W; Sun, X; Wang, Q; Xiao, E; Zhang, M, 2019) | 0.51 |
| " The in vitro gastric bioaccessibility (BAc) was determined for these contaminants, as was in vivo oral bioavailability (BAv), using a mass balance approach in male Sprague-Dawley rats." | ( Towards an exposure narrative for metals and arsenic in historically contaminated Ni refinery soils: Relationships between speciation, bioavailability, and bioaccessibility. Bellantino Perco, M; Bolger, GT; Dutton, MD; Ford, F; Gopalapillai, Y; Hale, B; Lopez, K; Taylor, SR; Vasiluk, L, 2019) | 0.51 |
| "The robustness of in vitro bioaccessibility assays to predict oral relative bioavailability (RBA) of multiple metals in contaminated soils requires validation using additional soil samples." | ( As, Cd, and Pb relative bioavailability in contaminated soils: Coupling mouse bioassay with UBM assay. Chen, XQ; Li, HB; Li, LZ; Li, MY; Luo, YM; Ma, LQ; Tu, C; Wang, JY; Zhu, X, 2019) | 0.51 |
| " However, sediment particle sizing was a major determinant of total metal concentrations of all three metals, and bioavailability was always much lower and within recommended guidelines." | ( Concentrations of some metals in the nearshore marine sediments of Western Australia's Pilbara Region. Stoddart, CW; Stoddart, JA; Welsh, JQ, 2019) | 0.51 |
| " This study demonstrates that not only water-soluble and exchangeable arsenic but also humic-bound fraction should be considered when assessing As bioavailability and toxicity." | ( The distribution of arsenic fractions and alkaline phosphatase activities in different soil aggregates following four months As(V) ageing. He, W; Li, H; Lu, G; Mallavarapu, M; Tian, H; Wang, Z, 2019) | 0.51 |
| " In view of the difficulty of removing arsenic from water and food, one alternative is to reduce its bioavailability (the amount that reaches the systemic circulation after ingestion)." | ( Dietary Compounds To Reduce In Vivo Inorganic Arsenic Bioavailability. Chiocchetti, G; Cimbalo, A; Clemente, MJ; Devesa, V; Vélez, D, 2019) | 0.51 |
| " This work studies the solubility and bioavailability of arsenic in the soils of watercourses that drain into the Mar Menor, using nine single chemical extractions with different reagents." | ( Assessment of the risk associated with mining-derived arsenic inputs in a lagoon system. Gómez-Martínez, MDC; Martínez-López, S; Martínez-Sánchez, MJ; Pérez-Sirvent, C, 2020) | 0.56 |
| " Also, As naturally found in husked-rice was evaluated by in vivo bioavailability in humans." | ( Availability of arsenic in rice grains by in vitro and in vivo (humans) assays. Batista, BL; Castro, CE; Freire, BM; Pedron, T; Ribal, LF, 2019) | 0.51 |
| " Adoption of transgenic techniques for development of rice cultivars with low accumulation in edible plant parts could be a realistic option that would permit rice cultivation in soils with high bioavailability of these metal(loid)s." | ( Metal(loid)s (As, Hg, Se, Pb and Cd) in paddy soil: Bioavailability and potential risk to human health. Bhaduri, D; Chatterjee, D; Khanam, R; Kumar, A; Kumar, U; Mohanty, S; Nayak, AK; Panneerselvam, P; Pathak, H; Satapathy, BS; Shahid, M; Tripathi, R; Vijayakumar, S, 2020) | 0.56 |
| " For humans, the unified bioaccessibility method (UBM) assesses oral bioaccessibility, while for soil fauna such as land snails, the bioaccumulation test reflects the bioavailability of contaminants." | ( Bioaccessibility of metal(loid)s in soils to humans and their bioavailability to snails: A way to associate human health and ecotoxicological risk assessment? de Vaufleury, A; Douay, F; Gimbert, F; Louzon, M; Morin-Crini, N; Pauget, B; Pelfrêne, A, 2020) | 0.56 |
| " One realistic method is the assisted phytostabilization, which aims at establishing a vegetation cover on the soil that will reduce metal(loid) bioavailability and spreading through the prevention of wind erosion and water leaching." | ( Contrasted tolerance of Agrostis capillaris metallicolous and non-metallicolous ecotypes in the context of a mining technosol amended by biochar, compost and iron sulfate. Bourgerie, S; Gaillard, M; Lebrun, M; Miard, F; Morabito, D; Nandillon, R; Sabatier, S, 2021) | 0.62 |
| " According to the sequential extraction experiments, only less than 5% of Hg and As were associated with the exchangeable fraction, while over 80% of them were found in the residual fraction, indicating low mobility and bioavailability of both Hg and As." | ( The distributions, contamination status, and health risk assessments of mercury and arsenic in the soils from the Yellow River Delta of China. Ge, M; Liu, G; Liu, H; Liu, Y; Yuan, Z, 2019) | 0.51 |
| "This research focuses on the effects of the composting process on oxytetracycline antibiotic degradation and the bioavailability of arsenic and copper." | ( Changes in Arsenic and Copper Bioavailability and Oxytetracycline Degradation during the Composting Process. Cheng, D; Feng, Y; Li, Z; Liu, Y; Shehata, E, 2019) | 0.51 |
| " The results showed that the bioavailability of Pb and As in the soil and their accumulation in the seedlings were reduced when PFM was added to the soil." | ( Phosphate-modified ferric-based material remediates lead and arsenic co-contaminated soil and enhances maize seedling growth. Li, Y; Lu, M; Tu, N; Yuan, Y, 2020) | 0.56 |
| " TG addition significantly improved the rice plants growth and reduced the bioavailability of Cd, Pb and As." | ( Simultaneous immobilization of the cadmium, lead and arsenic in paddy soils amended with titanium gypsum. Chen, J; Chen, Z; Dai, Y; Gustave, W; Liu, X; Maguffin, SC; Qiu, D; Tang, X; Xu, J; Yuan, H; Zhai, W; Zhao, W, 2020) | 0.56 |
| " Both biochar and Ca-MBC treatments increased soil pH, decreased the bioavailability of cadmium." | ( A novel calcium-based magnetic biochar is effective in stabilization of arsenic and cadmium co-contamination in aerobic soils. Huang, D; Li, Z; Liu, X; Parikh, SJ; Tang, C; Wu, J; Xu, J, 2020) | 0.56 |
| " Contrary to arsenic, phosphorus bioavailability was shown to decrease in the arsenic/iron flux maxima." | ( Localized Intensification of Arsenic Release within the Emergent Rice Rhizosphere. Fang, W; Gao, Y; Guan, DX; Luo, J; Ma, LQ; Moreno-Jimenez, E; Williams, PN; Yin, DX; Zhang, H; Zhao, FJ, 2020) | 0.56 |
| " Estimating the relative bioavailability of arsenic present in these media is a critical element in assessing the risks associated with aggregate exposure to this toxic metalloid during their early life." | ( Intra- and Interlaboratory Evaluation of an Assay of Soil Arsenic Relative Bioavailability in Mice. Bradham, K; Diamond, GL; Elek, B; Farthing, A; Herbin-Davis, K; Herde, C; Herde, P; Juhasz, AL; Thomas, DJ, 2020) | 0.56 |
| " The role that DOM plays on the bioavailability of arsenic to microbes is often invoked but remains untested experimentally." | ( Dissolved organic matter controls of arsenic bioavailability to bacteria. Garnier, C; Lenoble, V; Misson, B; Pothier, MP; Poulain, AJ; Rentmeister, C, 2020) | 0.56 |
| "In this study, we investigated the mechanism of decrease in arsenic (As) bioavailability after addition of biochar (BC) supplemented with iron (Fe)- manganese (Mn)- cerium (Ce) oxide (FMCBC) to As-contaminated paddy soil." | ( Effect of Fe-Mn-Ce modified biochar composite on microbial diversity and properties of arsenic-contaminated paddy soils. Gao, M; Liu, X; Song, Z; Zhang, G, 2020) | 0.56 |
| " Calcium can reduce the accumulation and toxicity of several metals, but soil acidification in cities leads to a decrease in bioavailability of this element." | ( Consequences of trace metal cocktail exposure in zebra finch (Taeniopygia guttata) and effect of calcium supplementation. Bleu, J; Boos, A; Del Nero, M; El Masoudi, I; Massemin, S; Ronot, P; Saulnier, A; Zahn, S, 2020) | 0.56 |
| " Although all arsenolipids were highly bioavailable in Caenorhabditis elegans, only the AsHCs were substantially metabolized to thioxylated or shortened metabolic products and induced significant toxicity, affecting both survival and development." | ( Toxicity of three types of arsenolipids: species-specific effects in Caenorhabditis elegans. Aschner, M; Baesler, J; Bornhorst, J; Ebert, F; Feldmann, J; Francesconi, K; Guttenberger, N; Meyer, S; Raab, A; Raber, G; Schwerdtle, T; Xiong, C; Ziemann, V, 2020) | 0.56 |
| "Soils have the ability to modify contaminant bioavailability and toxicity." | ( Predicting the modifying effect of soils on arsenic phytotoxicity and phytoaccumulation using soil properties or soil extraction methods. Basta, NT; Dayton, EA; Zhang, X, 2020) | 0.56 |
| ", and the mechanism on reducing As and Cd bioavailability in soil were also investigated." | ( Simultaneous reduction of arsenic and cadmium bioavailability in agriculture soil and their accumulation in Brassica chinensis L. by using minerals. Dong, Y; He, Y; Jin, X; Lin, H; Luo, M, 2020) | 0.56 |
| " Further, the key biochemistry promoting soil As bioavailability was studied to better understand the underlying processes." | ( Using rice as a remediating plant to deplete bioavailable arsenic from paddy soils. He, S; Ma, LQ; Wang, X; Wu, X; Yin, Y, 2020) | 0.56 |
| " The primary objective of this study was to evaluate the in vitro bioaccessibility and bioavailability of Arsenic (As), Cadmium (Cd) and Lead (Pb) in mineral clay samples collected from the Sierra Mountains (USA) using the Unified Bioaccessibility Research Group of Europe (UBM) method and the Caco-2 permeability assay, respectively." | ( In-vitro bioaccessibility and bioavailability of heavy metals in mineral clay complex used in natural health products. Chen, X; Kitts, DD; Singh, A, 2020) | 0.56 |
| " However, the evaluation of relative bioavailability (RBA) or bioaccessibility (BA) is limited in the rice bran." | ( Comparison of bioaccessibility and relative bioavailability of arsenic in rice bran: The in vitro with PBET/SHIME and in vivo with mice model. Cai, X; Cui, Y; Du, H; Li, Y; Sun, G; Wang, P; Yin, N, 2020) | 0.56 |
| " This study compared the effects of carbide slag, lodestone and biochar on the bioavailability of As and Cd in soil and their accumulation in rice tissues and root Fe-Mn plaque at tillering and mature stages in a paddy field." | ( Effects of carbide slag, lodestone and biochar on the immobilization, plant uptake and translocation of As and Cd in a contaminated paddy soil. Dai, Z; Huang, Y; Liu, G; Meng, J; Tang, C; Xu, J, 2020) | 0.56 |
| " Metal-microbe interactions and heatmap analysis revealed that the bioavailability of metal(loid)s promoted the niche partitioning of microbial species." | ( Bioavailable metal(loid)s and physicochemical features co-mediating microbial communities at combined metal(loid) pollution sites. Chen, Q; Liu, T; Sun, W; Wang, J, 2020) | 0.56 |
| " However, the microstructure and ultrastructure of cardiac tissue, as well as the activity of its antioxidant defenses front of disturbances in the mineral bioavailability induced by arsenic are still scarce." | ( Arsenic induces dose-dependent structural and ultrastructural pathological remodeling in the heart of Wistar rats. Bastos, DSS; Cossolin, JFS; de Oliveira, LL; de Paiva Coimbra, JL; Ervilha, LOG; Machado-Neves, M; Santos, EC; Souza, ACF, 2020) | 0.56 |
| " Arsenic (As) bioavailability and leaching characteristics of spiked red and calcareous soils (150 mg As/kg) amended with or without LDH@BCs were investigated using soil column." | ( Arsenic adsorption on layered double hydroxides biochars and their amended red and calcareous soils. Chen, Q; Gao, X; Guan, CY; Guo, L; Peng, Y; Wang, Q; Yang, F, 2020) | 0.56 |
| " The CF treatment increased As bioavailability in the rhizosphere soil and soil pore water, which enhanced As uptake and transport to the xylem in rice plants by inducing the expressions of silicon transporter genes (OsLsi1 and OsLsi2) compared to the IF treatment." | ( Water management affects arsenic uptake and translocation by regulating arsenic bioavailability, transporter expression and thiol metabolism in rice (Oryza sativa L.). Cao, Z; Chen, M; Guan, M; Pan, J; Xu, P; Yang, Y, 2020) | 0.56 |
| "This study aims to investigate the relationship between key physicochemical parameters related to composting process and bioavailability of Cd, As and Cr during swine manure composting through regulating different initial carbon to nitrogen (C/N) ratios (15:1, 20:1, 25:1) and bulking agent types (straw, green waste)." | ( Potential mechanisms involving the immobilization of Cd, As and Cr during swine manure composting. Guo, HN; Liu, HT; Wang, LX, 2020) | 0.56 |
| " We postulate that solid-phase iron reduction in anoxic microsites present in the rhizosphere of unsaturated soil is a key driver for mobilization and bioavailability of contaminants under nonflooded irrigation." | ( Ferrihydrite Reduction Increases Arsenic and Uranium Bioavailability in Unsaturated Soil. Kaiser, M; Malakar, A; Panda, B; Ray, C; Snow, DD; Walia, H, 2020) | 0.56 |
| " On average, biochar application significantly decreased the bioavailability of Cd in soils by 50." | ( Does biochar inhibit the bioavailability and bioaccumulation of As and Cd in co-contaminated soils? A meta-analysis. Chai, G; Tian, X; Wang, D; Zhang, J; Zhao, X, 2021) | 0.62 |
| " The physiologically based extraction test (PBET) also proved that the bioavailability of As and Cd was reduced after the modified zeolite treatment." | ( Simultaneous immobilization of As and Cd in a mining site soil using HDTMA-modified zeolite. Hu, X; Wang, Q; Wen, J; Xing, L; Yan, C; Yuan, L, 2021) | 0.62 |
| "The aim of this study was to evaluate the effect of raw (RawBC) and iron (Fe)-modified biochar (FeBC) derived from Platanus orientalis Linn branches on the plant growth, enzyme activity, and bioavailability and uptake of As, Cd, and Pb by rice in a paddy soil with continuously flooded (CF) or alternately wet and dry (AWD) irrigation in a pot experiment." | ( Iron-modified biochar and water management regime-induced changes in plant growth, enzyme activities, and phytoavailability of arsenic, cadmium and lead in a paddy soil. Chen, H; Hou, D; Li, Y; Liang, Y; Pohořelý, M; Rinklebe, J; Sarkar, B; Shaheen, SM; Song, H; Wang, H; Wen, E; Wong, JWC; Wu, F; Xu, S; Yang, X, 2021) | 0.62 |
| " Low bioavailability was correlated to plant's internal vascular structure that was found more rigid and firm in dry-wet field grown plants." | ( Arsenic dynamics and flux assessment under drying-wetting irrigation and enhanced microbial diversity in paddy soils: A four year study in Bengal delta plain. Bose, S; Giri, B; Jaiswal, MK; Majumdar, A; Srivastava, AK; Srivastava, S; Upadhyay, MK, 2021) | 0.62 |
| " In the overall attempt, the present investigation corroborates the insinuation of specific management practices in quantifying the reduction of As bioavailability in rice with subject to the concern of reducing human health risk." | ( Inhibition of arsenic transport from soil to rice grain with a sustained field-scale aerobic rice cultural practice. Banik, P; Majumder, S, 2021) | 0.62 |
| " In this study, hexadecyl trimethyl ammonium bromide (HDTMA-Br) modified or unmodified biochar on As mobility and bioavailability in soil were studied." | ( Mobilization or immobilization? The effect of HDTMA-modified biochar on As mobility and bioavailability in soil. Hu, X; Wang, Q; Wen, J; Xing, L; Yan, C, 2021) | 0.62 |
| " The bioavailability of dietary AsIII was lower than that of AsV, probably because AsIII has a lower ability to pass through fish tissues." | ( The dynamic changes of arsenic biotransformation and bioaccumulation in muscle of freshwater food fish crucian carp during chronic dietborne exposure. Cui, D; Li, H; Song, Y; Yang, Z; Zhang, P; Zhang, Z, 2021) | 0.62 |
| " Graphene significantly decreased the bioavailability of arsenic because of its adsorption capability and spatial structure." | ( Ameliorative effect of graphene nanosheets against arsenic-induced toxicity in mice by oral exposure. Chen, L; Li, H; Liu, S; Wu, B; Yu, Y; Zhang, J, 2021) | 0.62 |
| ") quality and yield by increasing arsenic (As) bioavailability in paddy soils." | ( Warming facilitates microbial reduction and release of arsenic in flooded paddy soil and arsenic accumulation in rice grains. Chen, Z; Gustave, W; He, X; Huang, Y; Liu, X; Ma, LQ; Manzoor, M; Tang, X; Wan, Q; Xu, J; Yuan, H, 2021) | 0.62 |
| " Our results highlight the role of various aspergilli strains in this process via production of acidic metabolites that affect mobility and bioavailability of coprecipitated contaminants." | ( Mobilisation of hazardous elements from arsenic-rich mine drainage ochres by three Aspergillus species. Bujdoš, M; Farkas, B; Kim, H; Matúš, P; Miglierini, MB; Mitróová, Z; Urík, M, 2021) | 0.62 |
| " Arsenic bioavailability was also determined using the ARSOlux test system." | ( Cancer and non-cancer risks in humans exposed to trace elements in drinking water from a crater lake (Bosumtwi/Bosomtwe). Akyeampong, S; Amankwaa, G; Cao, Y; Gyimah, E; Huang, W; Ni, X; Yin, X; Zhang, L, 2021) | 0.62 |
| " Arsenic mobility determines its bioavailability and entry into the food chain." | ( Mobility of arsenic in the growth media of rice plants (Oryza sativa subsp. japonica. 'Koshihikari') with exposure to copper oxide nanoparticles in a life-cycle greenhouse study. Cobb, GP; Li, J; Liu, J; Perrotta, B; Wolfe, K, 2021) | 0.62 |
| " Because the bioavailability of As varies depending on the As chemical fraction and exposure conditions, chemical assessment of As fractions in soil around mine waste is essential to understand their impact on soil ecosystem." | ( Effect of bioavailable arsenic fractions on the collembolan community in an old abandoned mine waste. Cho, K; Kim, JG; Kim, MS; Lee, YS; Min, HG; Wee, J, 2021) | 0.62 |
| "Rice consumption is a major dietary source of human exposure to arsenic (As), with As bioavailability being an important factor influencing its health risk." | ( Arsenic bioaccessibility in rice grains via modified physiologically-based extraction test (MPBET): Correlation with mineral elements and comparison with As relative bioavailability. Chen, S; Cheng, J; Li, H; Li, J; Liu, X; Ma, LQ, 2021) | 0.62 |
| " Hence, reducing the bioavailability of these metal(loids) in soils and decreasing their accumulation in rice grains is essential for agroecology, food safety, and human health." | ( Effect of calcium and iron-enriched biochar on arsenic and cadmium accumulation from soil to rice paddy tissues. Arafat, MY; Chen, Y; Islam, MS; Khan, ZH; Li, Y; Ma, J; Magid, ASIA; Weng, L, 2021) | 0.62 |
| "Animal bioassays have been developed to estimate oral relative bioavailability (RBA) of metals in soil, dust, or food for accurate health risk assessment." | ( An interlaboratory evaluation of the variability in arsenic and lead relative bioavailability when assessed using a mouse bioassay. Juhasz, AL; Li, HB; Li, J; Li, MY; Li, SW; Liang, JH; Ma, LQ; Ning, H; Wang, MY; Xue, RY, 2021) | 0.62 |
| "Iron plaques have been found to limit the phytoremediation efficiency by reducing iron solubility, while chelating agents can increase the bioavailability of iron from Fe plaques to numerous terrestrial plants." | ( The effect of chelating agents on iron plaques and arsenic accumulation in duckweed (Lemna minor). Lv, SM; Tan, AJ; Yang, GL; Yang, MX, 2021) | 0.62 |
| " Biotransformation mechanisms and speciation of arsenic have been studied, but few reports have addressed the relationships among speciation, toxicity, and bioavailability in biological systems." | ( Toxicity mechanisms of arsenic compounds in aquatic organisms. Byeon, E; Kang, HM; Lee, JS; Yoon, C, 2021) | 0.62 |
| " However, the degradation and transformation mechanisms of ROX in paddy soil which determine As bioavailability and uptake by rice are still unclear." | ( Roxarsone transformation and its impacts on soil enzyme activity in paddy soils: A new insight into water flooding effects. An, YL; Chen, JH; Cui, JL; Fang, LP; Gan, SC; Guo, PR; Zhao, YP, 2021) | 0.62 |
| "Phosphorus (P) can affect the bioavailability and mobility of arsenic (As) in paddy soil-plant system, but it is not clear how different forms of phosphorus fertilizers affect P/As molar ratio in soil and how the ratio in turn affects the competitive uptake of P and As in two genotypes." | ( Effect of P/As molar ratio in soil porewater on competitive uptake of As and P in As sensitive and tolerant rice genotypes. Fu, Q; Hu, H; Liu, M; Rao, X; Yang, Y; Zhang, X; Zhu, J, 2021) | 0.62 |
| "Water management has opposite effects on the bioavailability of Cd and As in soil." | ( Effects of optimized water management on the uptake and translocation of cadmium and arsenic in Oryza sativa L. in two contaminated soils. Bao, Q; Bao, W; Ding, Y; Huang, Y, 2022) | 0.72 |
| " Plus, due to their surface reactivity, nanoplastics could sorb and thus increase metals bioavailability to aquatic filter-feeding organisms (e." | ( Molecular impacts of dietary exposure to nanoplastics combined with arsenic in Canadian oysters (Crassostrea virginica) and bioaccumulation comparison with Caribbean oysters (Isognomon alatus). Baudrimont, M; Gigault, J; Gutierrez-Villagomez, JM; Langlois, VS; Lebordais, M, 2021) | 0.62 |
| " These results overall confirm the method as robust and reliable for demonstrating the reduction of the bioavailability of As in soil by S-nZVI sequestration." | ( Oryza sativa as a Tool for Assessing Arsenic Efficacy of Arsenic Remediation of Agricultural Soils by Sulfidated Zerovalent Iron Nanoparticles. Betancor, L; Ghoshal, S; Rahim, AA; Umpierrez-Failache, M, 2022) | 0.72 |
| " However, the evaluation of As relative bioavailability (As-RBA) or bioaccessibility in vegetables is still unexplored." | ( Comparative evaluation of in vivo relative bioavailability and in vitro bioaccessibility of arsenic in leafy vegetables and its implication in human exposure assessment. Chen, J; Chen, X; Gu, M; Liang, H; Qin, Y; Shohag, MJI; Wei, Y; Zhang, Z; Zheng, X, 2022) | 0.72 |
| " This study analyzed the pollution characteristics and probabilistic health risks of exposure to iAs, Pb, Cd, Cr, and Hg in rice produced in a typical multi-mining county using Monte Carlo simulation, a geographic information system, and bioavailability analysis." | ( Probabilistic health risk assessment of inorganic arsenic and some heavy metals in rice produced from a typical multi-mining county, China. Chen, W; Ge, D; Hao, H; Lv, Y; Wen, Y, 2022) | 0.72 |
| " The ability of sulfur (S) to alleviate As toxicity and accumulation is clearly size dependent as NS could effectively reduce bioavailability and accumulation of As in rice via modulating the gene expression activity of As transport, S assimilatory, and glutathione synthesis pathways to facilitate AsIII detoxification." | ( Nanoscale Sulfur Improves Plant Growth and Reduces Arsenic Toxicity and Accumulation in Rice ( Dhankher, OP; G Meselhy, A; Guo, Z; Musante, C; Sharma, S; Singh, G; Tripathi, RD; White, JC; Xing, B; Yuan, H, 2021) | 0.62 |
| " However, periodic monitoring of As bioavailability in these areas is recommended." | ( Environmental and human-health risks of As in soils with abnormal arsenic levels located in irrigated agricultural areas of Paracatu (MG), Brazil. Alvarenga, IFS; Feitosa, MM; Guilherme, LRG; Jara, MS; Lima, GJEO; Resende, T; Vilela, FJ, 2021) | 0.62 |
| " According to the bioconcentration factor, the bioavailability of soil is higher in JHP compared with other rice-growing areas owing to the unique hydrogeological conditions and irrigation using groundwater with high As content." | ( Distribution, bioavailability, and human health risk assessment of arsenic in groundwater-soil-rice system in the Jianghan Plain, Central China. Du, Y; Han, Z; Ma, T; Shen, S; Yu, H, 2022) | 0.72 |
| "Improvement of nutrient use efficiency and limiting trace elements such as arsenic and uranium bioavailability is critical for sustainable agriculture and food safety." | ( Ferrihydrite enrichment in the rhizosphere of unsaturated soil improves nutrient retention while limiting arsenic and uranium plant uptake. Kaiser, M; Maharjan, B; Malakar, A; Ray, C; Rudnick, D; Shields, J; Snow, DD; Walia, H, 2022) | 0.72 |
| " Exogenously applied Si and AM species enhanced soil glomalin and phosphatases activity, hence decreased metal bioavailability in soil, increased plant nutrient acquisition, biomass and chlorophylls; with maximum benefits provided by M2, closely followed by Si and least by M1." | ( Arbuscular mycorrhizae and silicon alleviate arsenic toxicity by enhancing soil nutrient availability, starch degradation and productivity in Cajanus cajan (L.) Millsp. Bhalla, S; Garg, N, 2021) | 0.62 |
| " This study aimed to determine the impact of goethite-modified biochar (GB) on bioavailability of both Cd and As in Cd- and As- polluted paddy soil." | ( Goethite modified biochar simultaneously mitigates the arsenic and cadmium accumulation in paddy rice (Oryza sativa) L. Chen, C; Irshad, MK; Noman, A; Shang, J; Wang, Y; Yin, Y, 2022) | 0.72 |
| " The results showed that the co-application of water management and foliar spraying Si could effectively decrease the bioavailability of Cd and As in soil and reduce the uptake and transport of Cd and As in rice." | ( Co-application of water management and foliar spraying silicon to reduce cadmium and arsenic uptake in rice: A two-year field experiment. Gu, J; Liao, B; Wei, B; Zeng, P; Zhou, H, 2022) | 0.72 |
| " However, little is known about the influence of gut microbiota on As bioavailability from incidental ingestion of soil." | ( Predictive capabilities of in vitro colon bioaccessibility for estimating in vivo relative bioavailability of arsenic from contaminated soils: Arsenic speciation and gut microbiota considerations. Cai, X; Cui, Y; Du, H; Feng, R; Fu, Y; Sun, G; Wang, P; Yin, N, 2022) | 0.72 |
| " The aging of dry-wet and freeze-thaw had an opposite effect on the bioavailability of As." | ( Contrasting effects of dry-wet and freeze-thaw aging on the immobilization of As in As-contaminated soils amended by zero-valent iron-embedded biochar. Cao, X; Fan, J; Qiu, H; Xu, X; Xu, Z; Yu, Y; Zhang, P; Zhao, L, 2022) | 0.72 |
| " Moreover, although Sb and As are often assumed to have similar biogeochemical behavior, identified differences in the controlling factors affecting mobility and bioavailability of Sb and As in soils need further investigation." | ( Bioavailability of antimony and arsenic in a flowering cabbage-soil system: Controlling factors and interactive effect. Chang, C; Chen, C; Du, Y; Hu, M; Li, F; Wang, Q; Yu, HY; Zhang, X, 2022) | 0.72 |
| "Continuous flooding has been widely used in paddy field to decrease the accumulation of heavy metal(loid)s by rice due to their decreased solubility and bioavailability of most heavy metal(loid)s under water flooding condition." | ( The effect of water flooding at grain-filling stage on the uptake of heavy metal(loid)s by rice in slightly alkaline paddy soil. Zhou, J, 2022) | 0.72 |
| " Arsenic has been shown to inactivate endothelial nitric oxide synthase leading to a reduction of the generation and bioavailability of nitric oxide." | ( Mechanisms of Arsenic Exposure-Induced Hypertension and Atherosclerosis: an Updated Overview. Balarastaghi, S; Hayes, AW; Karimi, G; Rezaee, R; Yarmohammadi, F, 2023) | 0.91 |
| "Recent findings indicate that incidental ingestion of soil by humans primarily involves soil particles <150 µm, rather than <250 µm-sized fraction previously used for most oral bioaccessibility and bioavailability studies." | ( Effect of soil particle size and extraction method on the oral bioaccessibility of arsenic. Bacon, AR; Kozuch, M; Lowney, YW; Odezulu, NG; Portier, KM; Roberts, SM; Stuchal, LD, 2022) | 0.72 |
| " Bioaccessibility and bioavailability of As can be determined using in-vitro and in-vivo techniques that can be utilized as a tool to assess As exposure in humans." | ( Rice grain arsenic and nutritional content during post harvesting to cooking: A review on arsenic bioavailability and bioaccessibility in humans. Chowdhury, NR; Das, A; De, A; Gorain, PC; Joardar, M; Lama, U; Majumder, S; Mridha, D; Pal, R; Roychowdhury, T, 2022) | 0.72 |
| " Despite a competitive behavior of arsenic (AsV) with Pi, Serendipita indica association promotes plant growth by reducing arsenic bioavailability in the rhizosphere." | ( Impact of arsenic on phosphate solubilization, acquisition and poly-phosphate accumulation in endophytic fungus Serendipita indica. Kumar, M; Kushwaha, AS; Patel, DK; Thakur, RS, 2022) | 0.72 |
| "Temperature variation can have a significant impact on arsenic (As) bioavailability in paddy soils." | ( Double-edged effects of elevating temperature on the aging of exogenous arsenic in flooded paddy soils. Ding, C; Wang, X; Yue, Z; Zang, X; Zhang, T; Zhou, Z, 2022) | 0.72 |
| " Furthermore, the bioavailability of arsenic and its different forms in the crabs were studied by in vitro gastrointestinal digestion." | ( Determination of arsenic in Chinese mitten crabs (Eriocheir sinensis): Effects of cooking and gastrointestinal digestion on food safety. Cao, H; Du, M; Liu, H; Meng, J; Pan, Y; Wang, Z; Zhao, Y, 2022) | 0.72 |
| "In this study, topsoil and soil profiles were collected from typical karst areas in central Guizhou to investigate the accumulation and bioavailability of As in cultivated soils." | ( Lithological controls on arsenic accumulation in cultivated soils: observations from typical karst areas in Central Guizhou, Southwest China. Li, X; Liu, N; Meng, W; Wu, P, 2022) | 0.72 |
| "The remediation of legacy metal(loid) contaminated soils in-situ relies on the addition of [organic] amendments to reduce the mobility and bioavailability of metal(loid)s, improve soil geochemical parameters and restore vegetation growth." | ( Contrasting mobility of arsenic and copper in a mining soil: A comparative column leaching and pot testing approach. Beesley, L; Cerqueira, B; Covelo, EF; Forján, R; Gallego, JLR; Marcet, P; Rúa-Díaz, S; Trakal, L, 2022) | 0.72 |
| " This calculation requires estimation of the oral bioavailability of soil-borne (As)." | ( Evaluating the mouse model for estimation of arsenic bioavailability: Comparison of estimates of absolute bioavailability of inorganic arsenic in mouse, humans, and other species. Bradham, KD; Diamond, GL; Thomas, DJ, 2022) | 0.72 |
| "The soil environmental pollution situation has been severe in recent years, but studies on evaluating with bioavailability testing and prediction models are lacking, which makes it difficult to accurately assess the ecological risks of contaminated soil." | ( [Effect Factors and Model Prediction of Soil Heavy Metal Bioaccessibility]. Liu, ZT; Luo, JJ; Tian, B; Wang, XN; Wu, F; Zhang, C; Zhang, JW, 2022) | 0.72 |
| " In this paper, 26 soil samples were analyzed to assess the speciation, bioavailability and human health risk of Arsenic (As), Mercury (Hg), Lead (Pb) and Cadmium (Cd) in urban soils of a heavy industrial city in NE China by using a Monte Carlo simulation approach." | ( Bioavailability and health risk of toxic heavy metals (As, Hg, Pb and Cd) in urban soils: A Monte Carlo simulation approach. Martín, JD; Wang, H; Yang, Q; Zhang, L, 2022) | 0.72 |
| " For the three biochar materials, S/Fe-BC showed the best effects on reducing the bioavailability of As and Pb, with a decrease of 40." | ( A comparative and modeled approach for three biochar materials in simultaneously preventing the migration and reducing the bioaccessibility of heavy metals in soil: Revealing immobilization mechanisms. Cao, X; Liang, W; Lou, Z; Peng, C; Tariq, M; Wan, J; Wang, G; Zhang, W, 2022) | 0.72 |
| " The bioavailability and toxicity of As in soil depends on its chemical species, which undergo multiple transformations driven primarily by soil microbes." | ( Transformation of arsenic species by diverse endophytic bacteria of rice roots. Chen, C; Gao, A; Yang, B; Yu, Y; Zhao, FJ, 2022) | 0.72 |
| " Initial assessments of bioavailability using a microbial biosensor indicated that arsenic in porewater is 72-96% bioavailable, and limited evidence that oxidative stress may contribute to the Daphnia sp." | ( Paleoecotoxicology: Developing methods to assess the toxicity of lake sediment records influenced by legacy gold mining. Blais, JM; Cheney, C; Pothier, M; Poulain, AJ; Sarma, SN; Thomas, PJ, 2022) | 0.72 |
| "Microbial induced phosphate precipitation (MIPP) is an advanced bioremediation technology to reduce the mobility and bioavailability of heavy metals (HMs), but the high level of HMs would inhibit the growth of phosphate solubilizing microbes." | ( Remediation of chromium, zinc, arsenic, lead and antimony contaminated acidic mine soil based on Phanerochaete chrysosporium induced phosphate precipitation. He, N; Hu, L; Jiang, C; Li, M, 2022) | 0.72 |
| " Total and bioavailability contributed significantly to As and Hg accumulation in corn, with root, stem3, and leaf accumulating more strongly." | ( Bioavailability, transfer, toxicological effects, and contamination assessment of arsenic and mercury in soil-corn systems. Dong, S; Long, S; Nan, Z; Wang, S; Wu, Y; Xu, J; Zhang, Q, 2023) | 0.91 |
| " Gradually increasing concentrations of KH was capable of decreasing the bioavailability of As to the rice plants, thus minimizing toxic effect of the metalloid." | ( Application of potassium humate to reduce arsenic bioavailability and toxicity in rice plants (Oryza sativa L.) during its course of germination and seedling growth. Acharya, K; Chowdhury, NR; Das, A; De, A; Joardar, M; Mridha, D; Ray, I; Roychowdhury, T; Sarkar, J, 2022) | 0.72 |
| "Despite arsenic (As) bioavailability being highly correlated with water status and the presence of iron (Fe) minerals, limited information is currently available on how externally applied Fe nanomaterials in soil-rice systems affect As oxidation and stabilization during flooding and draining events." | ( Enhanced oxidation and stabilization of arsenic in a soil-rice system by phytosynthesized iron oxide nanomaterials: Mechanistic differences under flooding and draining conditions. Chen, Z; Khan, NI; Lin, J; Owens, G; Wu, W, 2022) | 0.72 |
| " The bioavailabilities of different metals varied significantly, among which Cd has the highest bioavailability (> 30%)." | ( Driving effects and transfer prediction of heavy metal(loid)s in contaminated courtyard gardens using redundancy analysis and multilayer perceptron. Chen, W; Ge, D; Hao, H; Li, P; Li, Y; Lv, Y; Xu, J, 2022) | 0.72 |
| " The application of these treatments was efficient in reducing soil As bioavailability by 43." | ( Iron oxide doped rice biochar reduces soil-plant arsenic stress, improves nutrient values: An amendment towards sustainable development goals. Bose, S; Giri, B; Jaiswal, MK; Karwadiya, J; Majumdar, A; Upadhyay, MK, 2023) | 0.91 |
| " However, the ability of a range of Ca minerals to reduce oral bioavailability of lead (Pb), cadmium (Cd), and arsenic (As) from indoor dust remains unclear." | ( Ca Minerals and Oral Bioavailability of Pb, Cd, and As from Indoor Dust in Mice: Mechanisms and Health Implications. Chen, XQ; Cui, YS; Du, HY; Juhasz, AL; Li, HB; Li, LN; Lin, XY; Ma, LQ; Scheckel, KG; Shi, XX; Xue, RY; Xue, XM; Yin, NY; Zhu, YG, 2022) | 0.72 |
| "This study evaluated the ability of Ca minerals to reduce Pb, Cd, and As oral bioavailability from indoor dust and associated mechanisms." | ( Ca Minerals and Oral Bioavailability of Pb, Cd, and As from Indoor Dust in Mice: Mechanisms and Health Implications. Chen, XQ; Cui, YS; Du, HY; Juhasz, AL; Li, HB; Li, LN; Lin, XY; Ma, LQ; Scheckel, KG; Shi, XX; Xue, RY; Xue, XM; Yin, NY; Zhu, YG, 2022) | 0.72 |
| "Our study used a mouse model of exposure to household dust with various concentrations and species of Ca to determine whether different Ca minerals can reduce bioavailability of Pb, Cd, and As in mice and elucidate the mechanism(s) involved." | ( Ca Minerals and Oral Bioavailability of Pb, Cd, and As from Indoor Dust in Mice: Mechanisms and Health Implications. Chen, XQ; Cui, YS; Du, HY; Juhasz, AL; Li, HB; Li, LN; Lin, XY; Ma, LQ; Scheckel, KG; Shi, XX; Xue, RY; Xue, XM; Yin, NY; Zhu, YG, 2022) | 0.72 |
| "Nitrate reduction coupled with arsenic (As) oxidation strongly influences the bioavailability and toxicity of As in anaerobic environments." | ( Insight into universality and characteristics of nitrate reduction coupled with arsenic oxidation in different paddy soils. Chen, G; Du, Y; Feng, M; Huang, Y; Li, F; Li, X; Qiao, J, 2023) | 0.91 |
| " The results indicated that the coexistence of PFOA and different arsenic species in soils could enhance the bioavailability of arsenic species while reducing the bioavailability of PFOA, and inhibit the arsenic biotransformation process in earthworms." | ( How do different arsenic species affect the joint toxicity of perfluorooctanoic acid and arsenic to earthworm Eisenia fetida: A multi-biomarker approach. Cao, X; Cui, X; Cui, Z; Li, C; Qi, F; Wang, N; Wang, Z; Xue, W; Zhang, Z, 2023) | 0.91 |
| " Earthworms are frequently employed as sentinel organisms to investigate the bioavailability of As in contaminated soils." | ( Accumulation and speciation of arsenic in Eisenia fetida in sodium arsenite spiked soils - A dynamic interaction between soil and earthworms. Cao, Y; Geng, H; Li, L; Tian, S; Wang, Y; Xing, W; Yang, Y; Zhang, Z; Zhao, L, 2023) | 0.91 |
| " On the contrary, As was mainly adsorbed in calcareous soil, and its bioavailability was lower compared with Cd." | ( Temporal distribution and accumulation pattern of cadmium and arsenic in the actual field calcareous soil-maize system, northwest China. Dong, Y; Li, L; Long, S; Nan, Z; Ning, X; Wang, S, 2023) | 0.91 |
| " Consequently, the variation in metabolism alters the bioavailability of pioglitazone and the expected final effect." | ( Arsenic: A Perspective on Its Effect on Pioglitazone Bioavailability. Camacho-Luis, A; López-Guzmán, OD; Nieto-Delgado, G; Ponce-Peña, P; Pozos-Guillén, AJ; Salas-Pacheco, JM; Terrones-Gurrola, MCDR; Vértiz-Hernández, AA, 2023) | 0.91 |
| " However, time-consuming challenges, especially the optimal concentration in tumor tissue and bioavailability of ATO, remain to be overcome for its transition from the bench to the bedside." | ( Nanocarrier-based delivery of arsenic trioxide for hepatocellular carcinoma therapy. Cheng, M; Li, B; Li, F; Piao, JG; Sun, J; Wei, Y; Ye, T; Zheng, H; Zhou, M, 2022) | 0.72 |
| " In this study, by combining high-resolution imaging techniques with microbial community profiling, we examined the feasibility of utilizing the rhizoremediation of submerged macrophytes (Potamogeton crispus) to decrease As bioavailability and regulate its biotransformation in sediments." | ( Sediment arsenic remediation by submerged macrophytes via root-released O Chen, M; Ding, S; Fan, X; Li, C; Ma, X; Sun, Q; Wang, Y; Zhong, Z, 2023) | 0.91 |
| " Iron (Fe) is one of the most common element of the human and can influence the toxicity and bioavailability of As." | ( Arsenic and iron bioavailability in Caco-2 cells: The influence of their co-existence and concentration. Cai, X; Chang, X; Cui, L; Cui, Y; Fan, C; Li, Y; Liu, X; Wang, P; Wang, S; Yin, N, 2023) | 0.91 |
| " This will expand our knowledge on oral bioavailability of soil As and health risks from exposure to contaminated soils." | ( Role of microbial iron reduction in arsenic metabolism from soil particle size fractions in simulated human gastrointestinal tract. Cai, X; Chang, X; Cui, Y; Hu, Z; Liu, X; Sun, G; Wang, P; Xiao, P; Xiong, S; Yin, N; Zhou, Y, 2023) | 0.91 |
| "The oxidation and immobilization of arsenic (As) by manganese oxides have been shown to reduce As toxicity and bioavailability under abiotic conditions." | ( Effect of manganese oxides on arsenic speciation and mobilization in different arsenic-adsorbed iron-minerals under microbially-reducing conditions. Cai, X; Chang, X; Cui, Y; Du, X; Fan, C; Huang, X; Liu, X; Wang, P; Wang, S; Yin, N, 2023) | 0.91 |
| " To scientifically assess the health risks, in this study medical earthworms were analyzed for relative bioavailability (RBA) of arsenic (As) and lead (Pb) using a multiple gavage mouse model with liver, kidneys, brain, and leg bones as biomarkers for the first time." | ( Innovative accumulative risk assessment strategy of co-exposure of As and Pb in medical earthworms based on in vivo-in vitro correlation. Gao, F; Guo, YS; Jin, HY; Kong, DJ; Ma, SC; Song, QH; Sun, L; Wang, HY; Wang, JS; Wang, Q; Wei, F; Yang, JB; Zhang, WQ; Zhu, J; Zuo, TT, 2023) | 0.91 |
| " Compared with CK, the bioavailability of arsenic was reduced by 16." | ( Rhizosphere effect on the relationship between dissolved organic matter and functional genes in contaminated soil. Bai, Y; Huang, Q; Jin, F; Khan, MA; Li, D; Li, X; Liu, Q; Liu, Y; Lu, W; Mašek, O; Su, X; Wang, J; Wang, Q; Wei, S; Zhao, X; Zhou, Y; Zhu, Z, 2023) | 0.91 |
| " The issue is complex because two various uptake routes are concurrently involved, dermal and ingestion in guts, where the bioavailability of contaminants can considerably change." | ( Arsenic toxicity to earthworms in soils of historical As mining sites: an assessment based on various endpoints and chemical extractions. Dradrach, A; Gruss, I; Karczewska, A; Szopka, K; Twardowska, K; Twardowski, J, 2023) | 0.91 |
| " Soil Eh was the critical factor in the bioavailability of cadmium, while the behavior of arsenic in rhizosphere was associated with the iron cycle." | ( A combined strategy to mitigate the accumulation of arsenic and cadmium in rice (Oryza sativa L.). Han, R; Hao, Y; Li, G; Nriagu, J; Sun, G; Teng, HH; Wang, S; Wang, Z; Xiao, Z, 2023) | 0.91 |
| "8 μg/L) and other HMs after 30 d of incubation, reduced the bioavailability of As(V) and improved the quality and microbial activity of the soil." | ( Remediation of arsenic contaminated water and soil using mechanically (ball milling) activated and pyrite-amended electrolytic manganese slag. Du, D; Ha, Z; Lan, Y; Lin, Y; Ma, M; Tan, X; Zhang, TC, 2023) | 0.91 |
| " However, few previous studies have investigated the effects of interaction between DOM and microbes on the transformation and bioavailability of heavy metals in tailings soil at the molecular level after the addition of organic wastes." | ( Coupling effect of DOM and microbe on arsenic speciation and bioavailability in tailings soil after the addition of different biologically stabilized sludges. Chen, J; Hu, A; Li, K; Sun, W; Wang, D; Yuan, H; Zhang, W; Zhang, Y; Zhou, H, 2023) | 0.91 |
| " Here we assess the environmental bioavailability of As, Cr and Ni in topsoils from the Liège basin and Belgian Lorraine, two areas in Wallonia, Belgium, affected by elevated As, Cr and Ni background contents." | ( Environmental bioavailability of arsenic, nickel and chromium in soils impacted by high geogenic and anthropogenic background contents. Delmelle, P; Kaba, AJ; Pereira, B; Titeux, H; Vandeuren, A, 2023) | 0.91 |
| " Elevating the soil redox potential (Eh) has been shown to reduce As bioavailability and decrease As accumulation in rice grains." | ( Sustainable Immobilization of Arsenic by Man-Made Aerenchymatous Tissues in Paddy Soil. Chen, Z; Gustave, W; Kappler, A; Tang, X; Xu, J; Yuan, ZF; Zhang, T; Zhou, Y, 2023) | 0.91 |
| " Furthermore, on the basis of considering the bioavailability of HMs, we evaluated the multiple environmental routes and health risks to HMs in children and teenagers of eight age groups (2-<3, 3-<4, 4-<5, 5-<6, 6-<9, 9-<12, 12-<15, and 15-<18) in Beijing, China by Monte Carlo simulation approach." | ( Bioavailability-based risk assessment of various heavy metals via multi-exposure routes for children and teenagers in Beijing, China. Cai, J; Cen, K; Du, Z; Mu, Y; Song, Z; Tian, Z; Wei, J; Yin, Y, 2023) | 0.91 |
| " Antimony and As in sediments were mainly enriched in the fraction of residues, but the proportion of As in bioavailability was significantly higher than that of Sb." | ( Comparison of antimony and arsenic behaviour at the river-lake junction in the middle of the Yangtze River Basin. He, M; Lai, Z; Lin, C; Liu, H; Liu, X; Ouyang, W; Zeng, W, 2024) | 1.44 |
A dose-response relationship was suggested by the SMR for lung cancer which increased with increasing duration of exposure. No such relationship was evident for nonarsenicals. Low-dose As2O3 had the same effect as the conventional dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The same monkeys were later dosed with inorganic arsenic and 76% of it was excreted with the urine, and practically nil with the feces." | ( Arsenic excretion by monkeys dosed with arsenic-containing fish or with inorganic arsenic. Bryce, F; Charbonneau, SM; Sandi, E; Spencer, K, 1978) | 0.26 |
| " The effects on the amino acids are not due to a change in the food intake caused by dosing with arsenate." | ( The effects of sodium arsenate on the free amino acid levels in erythrocytes and plasma in rats. Kilroe-Smith, TA; McLoughlin, JL, 1979) | 0.26 |
| " In order to determine its mechanism of action, dose-response relationships of arsenite on a number of cellular functions were carried out." | ( Effects of arsenite on DNA repair in Escherichia coli. Meyn, MS; Rossman, TG; Troll, W, 1977) | 0.26 |
| " A dose-response relationship was suggested by the SMR for lung cancer which increased with increasing duration of exposure to arsenicals, but no such relationship was evident for nonarsenicals." | ( Lung cancer among pesticide workers exposed to inorganic arsenicals. Lilienfeld, AM; Mabuchi, K; Snell, LM, ) | 0.13 |
| " There was 1 death in the Se alone group, none in the As group, but 7 out of 10 animals receiving As+Se had died by the end of the 18 week dosing period." | ( Effects of selenium, alone and in combination with silver or arsenic, in rats. Cabe, PA; Carmichael, NG; Tilson, HA, 1979) | 0.26 |
| " Lung cancer mortality was found to be increased about five-fold and cardiovascular disease about two-fold, showing a dose-response relationship to arsenic exposure." | ( Arsenic exposure and mortality: a case-referent study from a Swedish copper smelter. Axelson, O; Dahlgren, E; Jansson, CD; Rehnlund, SO, 1978) | 0.26 |
| " The fed animals have been killed at definite times all along the experiment and the metals dosed in the body." | ( [Determination of various toxic minerals in spiruline algae of different origins, and evaluation of long-term toxicity in the rat of a lot of spiruline algae of Mexican origin]. Boudène, C; Collas, E; Jenkins, C, 1975) | 0.25 |
| " A dose-response relationship between blackfoot disease and the duration of water intake was also noted." | ( Effects and dose--response relationships of skin cancer and blackfoot disease with arsenic. Tseng, WP, 1977) | 0.26 |
| " Male Sherman rats were dosed at levels ranging from 200 mg/kg to 120 mug/kg." | ( Disposition of 14C and/or 74As-cacodylic acid in rats after intravenous, intratracheal, or peroral administration. Chernoff, N; DiPasquale, LC; Durham, WF; Farmer, JD; Hall, LL; Stevens, JT, 1977) | 0.26 |
| " In order to explore the possibility of a dose-response relationship, a dietary survey was carried out in 1972 in that city for measuring the daily fluid intake in the various age groups." | ( Ecological investigations on arsenic dietary intake and endemic chronic poisoning in man: dose-response curve. Zaldívar, R, 1977) | 0.26 |
| " Arsenite lowers the tumor incidence at higher dosage (80 ppm of As in supply water) as well, but animals developing tumors under these conditions demonstrate significantly enhanced tumor growth rates." | ( Inhibition of the genesis of spontaneous mammary tumors in C3H mice: effects of selenium and of selenium-antagonistic elements and their possible role in human breast cancer. Schneider, CJ; Schrauzer, GN; White, DA, 1976) | 0.26 |
| " Additionally, two such studies have revealed a dose-response relationship between arsenical exposure and lung carcinogenesis." | ( Inorganic arsenic--ambient level approach to the control of occupational cancerigenic exposures. Blejer, HP; Wagner, W, 1976) | 0.26 |
| " The inhibition of 14C-thymidine incorporation which is dependent on dosage and time, with larger doses of arsenic can be explained by a prevailing influence of enzymes of the synthesis system (e." | ( [Effect of arsenic on the incorporation of 14C-thymidine into DNAP of phytohaemagglutinin-treated lymphocytes (author's transl)]. Baron, D; Enderle, J; Petres, J, 1975) | 0.25 |
| " Risk of lung cancer among pottery workers was related to exposure to silica, although the dose-response gradient was not significant." | ( A nested case-control study of lung cancer among silica exposed workers in China. Blot, WJ; Chen, JQ; Chen, RA; Dosemeci, M; Hearl, FJ; McCawley, MA; McLaughlin, JK; Rexing, SH; Wu, Z, 1992) | 0.28 |
| ", exponential, power, additive relative rate, and linear) of Poisson and Cox proportional hazards models to examine the dose-response relationship." | ( A dose-response analysis and quantitative assessment of lung cancer risk and occupational cadmium exposure. Lemen, R; Schnorr, T; Smith, R; Stayner, L; Thun, M, 1992) | 0.28 |
| " Instead, selenium appears to operate by several mechanisms, depending on dosage and chemical form of selenium and the nature of the carcinogenic stress." | ( Selenium. Mechanistic aspects of anticarcinogenic action. Schrauzer, GN, ) | 0.13 |
| " The following review explores this broad topic, with special emphasis on toxicological principles including dose-response relationships and potential mechanisms, using cadmium as an example." | ( Toxicological principles of metal carcinogenesis with special emphasis on cadmium. Barter, RA; Coogan, TP; Waalkes, MP, 1992) | 0.28 |
| " Large population studies in an area of Taiwan with high arsenic levels in well water (170-800 micrograms/L) were used to establish dose-response relationships between cancer risks and the concentration of inorganic arsenic naturally present in water supplies." | ( Cancer risks from arsenic in drinking water. Bates, MN; Duggan, HM; Goeden, HM; Hertz-Picciotto, I; Hopenhayn-Rich, C; Kosnett, MJ; Smith, AH; Smith, MT; Wood, R, 1992) | 0.28 |
| " Based on a total of 898,806 person-years as well as 202 liver cancer, 304 lung cancer, 202 bladder cancer and 64 kidney cancer deaths, a significant dose-response relationship was observed between arsenic level in drinking water and mortality of the cancers." | ( Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water. Chen, CJ; Chen, CW; Kuo, TL; Wu, MM, 1992) | 0.28 |
| " On day 59, the dosage was doubled for the rest of the experiment, which ended on day 183." | ( Arsenic concentrations in tissues and body fluids of dogs on chronic low-level dietary sodium arsenite. Neiger, RD; Osweiler, GD, 1992) | 0.28 |
| " DMSA effectiveness was assessed at dosage levels of 0, 80, 160, and 320 mg/kg/day." | ( meso-2,3-Dimercaptosuccinic acid and prevention of arsenite embryotoxicity and teratogenicity in the mouse. Bosque, MA; Domingo, JL; Piera, V, 1991) | 0.28 |
| " The activity of each drug was expressed as: 1) in vitro: the minimal effective concentration which killed trypanosome population by 100% within 24 h of drug exposure (MEC100); the maximum tolerated concentration in which trypanosomes could propagate at the same rate as the controls during 48 h of drug exposure (MTC100); 2) in vivo: the curative dosage in 100% of infected mice (CD100); the highest ineffective dosage: 100% of infected mice remain infected (ID100)." | ( In vivo and in vitro sensitivity of Trypanosoma evansi and T. equiperdum to diminazene, suramin, MelCy, quinapyramine and isometamidium. Baltz, T; Giroud, C; Zhang, ZQ, 1991) | 0.28 |
| " From the food and the dosed emission, the daily intake was 466." | ( Mineral profile of serum in experimental copper intoxication of sheep from industrial emissions. Bires, J; Kovac, G; Vrzgula, L, 1991) | 0.28 |
| " Equimolar dosing schedules were used based upon realistic doses for the most toxic agent, BAL." | ( Evaluation of the efficacy of dimercapto chelating agents for the treatment of systemic organic arsenic poisoning in rabbits. Bright, JE; Inns, RH; Marrs, TC; Rice, P, 1990) | 0.28 |
| "A significant dose-response relation between ingested arsenic and several cancers has recently been reported in four townships of the endemic area of blackfoot disease, a unique peripheral artery disease related to the chronic arsenic exposure in southwestern Taiwan." | ( Ecological correlation between arsenic level in well water and age-adjusted mortality from malignant neoplasms. Chen, CJ; Wang, CJ, 1990) | 0.28 |
| "Following dosing with various levels of sodium arsenite (NaAsO2), differential [32P]-incorporation (turnover) of polypeptide fragments, generated by protease V8, from a set of four closely related stress proteins (SPs), termed 'c','b','x' and 'y', (80,000-84,000 Mr) was investigated by polyacrylamide gel (PAG) autoradiography." | ( Differential phosphate labeling of stress protein polypeptides in toxic dose response during S-phase of mouse lymphoma cells: a micro-electrophoretic study. Anson, JF; Burns, ER; Casciano, DA; Hinson, WG; Pipkin, JL, 1989) | 0.28 |
| "Age-adjusted mortality rates were analyzed to examine the dose-response relation between ingested arsenic levels and risk of cancers and vascular diseases among residents in the endemic area of blackfoot disease, a unique peripheral vascular disease associated with long-term exposure to high-arsenic artesian well water and confined to the southwestern coast of Taiwan." | ( Dose-response relation between arsenic concentration in well water and mortality from cancers and vascular diseases. Chen, CJ; Hwang, YH; Kuo, TL; Wu, MM, 1989) | 0.28 |
| " Ever use of water pipes was associated with a twofold elevation in risk when compared with tobacco abstainers, and a dose-response relation was observed with increasing categories of pipe-year (dose times duration) usage." | ( Relation of radon exposure and tobacco use to lung cancer among tin miners in Yunnan Province, China. Li, JY; Lubin, J; Mao, BL; McAdams, M; Qiao, YL; Rao, JY; Schatzkin, A; Taylor, PR; Xuan, XZ; Yao, SX, 1989) | 0.28 |
| "A study of the prevalence of skin cancer among 40,421 persons consuming arsenic-contaminated drinking water in Taiwan was used for a cancer dose-response assessment of ingested arsenic." | ( A dose-response analysis of skin cancer from inorganic arsenic in drinking water. Boyle, KE; Brown, KG; Chen, CW; Gibb, HJ, 1989) | 0.28 |
| " On Day 59, the dosage was doubled for the rest of the experiment, which ended on Day 183." | ( Effect of subacute low level dietary sodium arsenite on dogs. Neiger, RD; Osweiler, GD, 1989) | 0.28 |
| " Two other goats appeared to be cured with this dosage of suramin but later developed abnormal central nervous system (CNS) signs and parasitaemia." | ( Experimental infection of goats with Trypanosoma brucei ssp. and effects of treatment with suramin and Mel-B. Chumo, DA; Muriithi, RM; Mwangi, J; Reardon, MJ; Towett, S; Wellde, BT, 1989) | 0.28 |
| "We reviewed available literature on the effects of inorganic arsenic on the skin to determine the potential hazards and to collate information regarding dosage and exposure to the incidence of skin cancer." | ( Arsenic-induced skin toxicity. Shannon, RL; Strayer, DS, 1989) | 0.28 |
| " A dose-response relationship between blackfoot disease and the duration of water intake was also noted." | ( Blackfoot disease in Taiwan: a 30-year follow-up study. Tseng, WP, 1989) | 0.28 |
| " Arsenic levels in blood, urine, kidneys, and liver of rats were measured in additional animals of each sex dosed with 100 or 400 ppm roxarsone." | ( Toxic responses in F344 rats and B6C3F1 mice given roxarsone in their diets for up to 13 weeks. Abdo, KM; Elwell, MR; Montgomery, CA; Prejean, JD; Thompson, MB; Thompson, RB, 1989) | 0.28 |
| " A positive dose-response relationship was found between cumulative arsenic exposure and lung cancer mortality with an overall SMR of 372 (304-450, 95% confidence interval)." | ( Cumulative arsenic exposure and lung cancer in smelter workers: a dose-response study. Järup, L; Pershagen, G; Wall, S, 1989) | 0.28 |
| " In addition, PhAsO is shown to inhibit cytochalasin B binding to plasma membranes from insulin-stimulated adipocytes in a concentration-dependent manner which parallels the dose-response inhibition of hexose transport by PhAsO." | ( Direct interaction of phenylarsine oxide with hexose transporters in isolated rat adipocytes. Douen, AG; Jones, MN; Kacem, R, 1988) | 0.27 |
| "To investigate the distribution of trivalent arsenic (arsenite) in the pregnant rodent, CD-1 mice were dosed with sodium arsenite by ip injection or by gavage on gestation d 18 (copulation plug day = d 1)." | ( Uptake, distribution, and metabolism of trivalent arsenic in the pregnant mouse. Hood, RD; Meeks, RG; Tatum, FM; Vedel, GC; Zaworotko, MJ, 1988) | 0.27 |
| " A dose-response effect was observed over four levels of selenium exposure." | ( Chemical quality of maternal drinking water and congenital heart disease. Cohen, A; Rothman, KJ; Theodore, M; Zierler, S, 1988) | 0.27 |
| " Analyses by duration of arsenic exposure and interval since first exposure did not reveal any obvious dose-response relationships." | ( An update of respiratory cancer and occupational exposure to arsenicals. Baldwin, CL; Bond, GG; Ducommun, DJ; Sobel, W, 1988) | 0.27 |
| " These results agree with the finding that oral dosing of pregnant mice with arsenate has less effect on the conceptus than does treatment by injection." | ( Distribution, metabolism, and fetal uptake of pentavalent arsenic in pregnant mice following oral or intraperitoneal administration. Hood, RD; Meeks, RG; Tatum, FM; Vedel-Macrander, GC; Zaworotko, MJ, 1987) | 0.27 |
| " When a dose-response relation is based on airborne concentrations of arsenic, it is clearly concave downward, but when based on urine concentrations, it appears to be linear." | ( Exposure to arsenic and respiratory cancer. A reanalysis. Enterline, PE; Henderson, VL; Marsh, GM, 1987) | 0.27 |
| " The levels of arsenobetaine, which occurs naturally in these fish, did not appear to be affected by the oral dosing with sodium arsenate." | ( Trimethylarsine oxide in estuary catfish (Cnidoglanis macrocephalus) and school whiting (Sillago bassensis) after oral administration of sodium arsenate; and as a natural component of estuary catfish. Edmonds, JS; Francesconi, KA, 1987) | 0.27 |
| " By using internal controls, a dose-response relationship for lung cancer was observed with exposure to arsenic and SO2." | ( Some effects of cigarette smoking, arsenic, and SO2 on mortality among US copper smelter workers. Callahan, CM; Enterline, PE; Esmen, NA; Henderson, VL; Marsh, GM; Paik, M, 1987) | 0.27 |
| "Hamster dams dosed continuously with arsenate and exposed to short-term hyperthermia produced a greater percentage of malformed offspring than did hamster dams dosed with arsenate alone." | ( Teratogen concentration changes as the basis of the heat stress enhancement of arsenate teratogenesis in hamsters. Ferm, VH; Hanlon, DP, 1986) | 0.27 |
| " A statistically significant dose-response relationship was observed between lung cancer mortality and cumulative exposure to cadmium." | ( Mortality among a cohort of U.S. cadmium production workers--an update. Halperin, WE; Lemen, RA; Schnorr, TM; Smith, AB; Thun, MJ, 1985) | 0.27 |
| " A dose-response relationship was observed between SMRs of the cancers and blackfoot disease prevalence rate of the villages and townships in the endemic areas." | ( Malignant neoplasms among residents of a blackfoot disease-endemic area in Taiwan: high-arsenic artesian well water and cancers. Chen, CJ; Chuang, YC; Lin, TM; Wu, HY, 1985) | 0.27 |
| "Previous work on monkeys and on human volunteers led to the development of a schedule of diethylcarbamazine dosage suitable for the chemoprophylaxis of loiasis." | ( Experiments on the chemoprophylaxis of Onchocerca volvulus infection. Duke, BO, 1968) | 0.25 |
| " The battery of tests was administered on eight occasions, that is, before, at three-week intervals during dosing (PO or IP, five days each week for 15 weeks), and at three and six weeks after dosing." | ( Assessment of chemicals using a battery of neurobehavioral tests: a comparative study. Mitchell, CL; Pryor, GT; Tilson, HA; Uyeno, ET, ) | 0.13 |
| " injection of arsenic trioxide, at the dosage range of 1/4 to 1/40 LD50 into hybrid mice (CBA X C57B1/6J)F1, no induction of dominant lethals in male germ cells was observed." | ( [Arsenic trioxide inhibition of the thiophosphamide induction of mutations in mouse germ and somatic cells]. Kozachenko, VI; Pashin, IuV; Toroptsev, SN, 1984) | 0.27 |
| " The total arsenic concentration in blood and milk was measured during and after the period of MSMA administration while arsenic in urine and feces was measured for 10 days following administration of last dosage of MSMA." | ( Uptake, distribution and elimination of monosodium methanearsonate following long term oral administration of the herbicide to sheep and goats. Anderson, AC; Shariatpanahi, M, 1984) | 0.27 |
| " Clinical pathologic changes were not demonstrable at this dosage level according to glomerular filtration rate (creatinine clearance), fractional reabsorption of sodium, potassium, and chloride; plasma osmolar and free water clearance; and urinalysis." | ( Nephrotoxicity of sodium arsenate in dogs. Gribble, DH; Mariassy, A; Parker, HR; Peoples, SA; Tsukamoto, H, 1983) | 0.27 |
| " No dose-response relationship existed between arsenic ingestion and symptoms or physical findings compatible with peripheral neuropathy." | ( Neurologic evaluation of a population exposed to arsenic in Alaskan well water. Boyd, MH; Chirico-Post, J; Cox, DH; Feldman, RG; Kreiss, K; Landrigan, PJ; Niles, CA; Sax, DS; Zack, MM, ) | 0.13 |
| " A dose-response analysis clearly indicates that the roasters and arsenic departments are risk places for the development of cancer, especially lung cancer." | ( Survival and mortality pattern among Swedish smelter workers. Wall, S, 1980) | 0.26 |
| " The dose-response patterns for lung, liver, and bladder cancers display a nonlinear dose-response relationship with arsenic exposure." | ( Significance of exposure assessment to analysis of cancer risk from inorganic arsenic in drinking water in Taiwan. Brown, KG; Chen, CJ, 1995) | 0.29 |
| " regarding two critical issues in arsenic risk assessment: the role of methylation in the dose-response relationship and the role of internal cancers." | ( Arsenic risk assessment. Beck, BD; Boardman, PD; Carlson-Lynch, H, 1994) | 0.29 |
| " Magnetometric evaluation of the effects of GaAs in rabbits dosed with 30 mg or 300 mg/animal showed significant decreased relaxation of iron particles at 1, 3, 7, 14, 21 and 28 days following instillation compared with the controls." | ( Magnetometric evaluation of the effects of gallium arsenide on the clearance and relaxation of iron particles. Aizawa, Y; Chiyotani, K; Inokuchi, N; Karube, H; Kotani, M; Takata, T; Tatsumi, H, 1993) | 0.29 |
| " For inks, a dose-response relation was observed." | ( [Occupational exposure and malignant hemopathies: a case-control study in Lyon (France)]. Ayzac, L; Bergeret, A; Bonhomme, I; Dananche, B; Fabry, J; Fevotte, J; Fière, D; Hours, M; Milan, JJ; Philippe, J, 1995) | 0.29 |
| " In a cohort exposed to airborne arsenic, a strong dose-response relation with respiratory cancer mortality had been established." | ( Controlling for time-since-hire in occupational studies using internal comparisons and cumulative exposure. Arrighi, HM; Hertz-Picciotto, I, 1995) | 0.29 |
| " These criticisms collectively posit a revisionist view that: 1) cancer incidence among the Taiwanese was amplified by a number of host and environmental factors not applicable elsewhere, 2) the cancer dose-response curve may not be linear at the lower exposures elsewhere, and 3) there is a toxicokinetic and metabolic threshold to cancer risk that was exceeded by the Taiwanese." | ( Risk and revisionism in arsenic cancer risk assessment. Crocetti, AF; Mushak, P, ) | 0.13 |
| " There was a significant dose-response relation between skin cancer prevalence and chronic arsenic exposure as indexed by duration of residence in the endemic area, duration of consumption of high-arsenic artesian well water, average arsenic exposure in parts per million (p." | ( Multiple risk factors associated with arsenic-induced skin cancer: effects of chronic liver disease and malnutritional status. Chen, CJ; Cheng, GS; Hsueh, YM; Kuo, TL; Wu, MM; Yu, HS, 1995) | 0.29 |
| " This dose-response relation remained significant after adjustment for age, sex, diabetes mellitus, proteinuria, body mass index, and serum triglyceride level." | ( Increased prevalence of hypertension and long-term arsenic exposure. Chen, CJ; Chen, SY; Hsueh, YM; Kuo, TL; Lai, MS; Shyu, MP; Tai, TY; Wu, MM, 1995) | 0.29 |
| " 3 and 10 days and 1, 3 and 6 months) and a dose-response experiment." | ( A unique pattern of hepatocyte proliferation in F344 rats following long-term exposures to low levels of a chemical mixture of groundwater contaminants. Baker, DC; Benjamin, SA; Constan, AA; Yang, RS, 1995) | 0.29 |
| "In order to elucidate the dose-response relationship between ingested inorganic arsenic and internal cancers, a total of 263 patients with blackfoot disease and 2293 healthy residents in the endemic area of arseniasis were recruited and followed up for 7 years." | ( Incidence of internal cancers and ingested inorganic arsenic: a seven-year follow-up study in Taiwan. Chen, CJ; Chiang, MH; Chiou, HY; Horng, SF; Hsueh, YM; Huang, CH; Liaw, KF; Lin, JS; Pu, YS, 1995) | 0.29 |
| " The low toxicity of DMPS and DMSA compared to BAL enabled doses of 160 mumol kg-1 on a more prolonged dosing schedule to be used for DMPS and DMSA." | ( Efficacy of dimercapto chelating agents for the treatment of poisoning by percutaneously applied dichloro(2-chlorovinyl)arsine in rabbits. Inns, RH; Rice, P, 1993) | 0.29 |
| "4%) was absorbed from aqueous vehicles over the entire dosage range." | ( In vitro percutaneous absorption of monosodium methanearsonate and disodium methanearsonate in female B6C3F1 mice. Hughes, MF; Rahman, MS, 1994) | 0.29 |
| " There was a dose-response relation between cumulative arsenic exposure and prevalence of diabetes mellitus." | ( Ingested inorganic arsenic and prevalence of diabetes mellitus. Chen, CJ; Chen, SY; Hsueh, YM; Kuo, TL; Lai, MS; Shyu, MP; Tai, TY; Wu, MM, 1994) | 0.29 |
| " All of the studies with quantitative data are consistent with a supralinear dose-response relationship." | ( Observations on the dose-response curve for arsenic exposure and lung cancer. Hertz-Picciotto, I; Smith, AH, 1993) | 0.29 |
| "The cardiovascular effects of inorganic arsenic have been documented, but the dose-response relationship between ischemic heart disease (ISHD) and long-term arsenic exposure remains to be elucidated." | ( Dose-response relationship between ischemic heart disease mortality and long-term arsenic exposure. Chen, CJ; Chiang, MH; Chiou, HY; Lin, LJ; Tai, TY, 1996) | 0.29 |
| " A dose-response relation was observed between the prevalence of peripheral vascular disease and the long-term arsenic exposure." | ( Dose-response relationship between peripheral vascular disease and ingested inorganic arsenic among residents in blackfoot disease endemic villages in Taiwan. Chen, CJ; Chong, CK; Tai, TY; Tseng, CH, 1996) | 0.29 |
| " A review of the dose-response relationships observed in arsenic genotoxicity assays is presented." | ( Implications of arsenic genotoxicity for dose response of carcinogenic effects. Beck, BD; Rudel, R; Slayton, TM, 1996) | 0.29 |
| "This investigation sought to examine whether methods proposed to control the healthy worker survivor effect would influence the shape or magnitude of the dose-response curve for respiratory cancer induced by arsenic." | ( Controlling the healthy worker survivor effect: an example of arsenic exposure and respiratory cancer. Arrighi, HM; Hertz-Picciotto, I, 1996) | 0.29 |
| " Ecologic studies in Taiwan have found a dose-response relation between ingestion of In-As from drinking water and bladder cancer, but questions have been raised concerning the validity and generalizability of the findings." | ( Bladder cancer mortality associated with arsenic in drinking water in Argentina. Bergoglio, R; Biggs, ML; Fuchs, A; Hopenhayn-Rich, C; Nicolli, H; Smith, AH; Tello, EE, 1996) | 0.29 |
| "Induction of cancer by inorganic arsenic occurs inconsistently between species and between routes of exposure, and it exhibits different dose-response relationships between different target organs." | ( Carcinogenic risks of inorganic arsenic in perspective. Byrd, DM; Griffiths, JC; Grumski, KS; Lai, S; Lamm, SH; Roegner, ML; Wilson, R, 1996) | 0.29 |
| " Cumulative dose-response relations to norepinephrine, nitroglycerin, and methacholine were determined." | ( Effect of arsenical drugs on in vitro vascular responses of pulmonary artery from heartworm-infected dogs. Bell, TG; Kaiser, L; Maksimowich, DS; Williams, JF, 1997) | 0.3 |
| " However, a significant dose-response relation was found for the long-term arsenic exposure indices." | ( Lipid profile and peripheral vascular disease in arseniasis-hyperendemic villages in Taiwan. Chen, CJ; Chong, CK; Tai, TY; Tseng, CH, 1997) | 0.3 |
| " It is concluded that while the available dataset is suitable to establish the hazard of skin cancer, it is too highly summarized for reliable dose-response assessment." | ( Skin cancer and inorganic arsenic: uncertainty-status of risk. Brown, KG; Greene, HL; Guo, HR; Kuo, TL, 1997) | 0.3 |
| " These findings suggest that low-power laser irradiation can accelerate bone regeneration in a midpalatal suture during rapid palatal expansion and that this effect is dependent not only on the total laser irradiation dosage but also on the timing and frequency of irradiation." | ( Stimulatory effects of low-power laser irradiation on bone regeneration in midpalatal suture during expansion in the rat. Saito, S; Shimizu, N, 1997) | 0.3 |
| " Sodium arsenite was found to increase SCEs and HFCs and to decrease RI in a dose-response pattern for both cases and controls." | ( Spontaneous and induced sister chromatid exchanges and delayed cell proliferation in peripheral lymphocytes of Bowen's disease patients and matched controls of arseniasis-hyperendemic villages in Taiwan. Chang, SH; Chen, CJ; Chiou, HY; Hsu, YH; Hsueh, YM; Li, SY; Liou, JC; Yeh, PM, 1997) | 0.3 |
| " When pooled data from the primary lymphocytes was compared to that obtained with the lymphoblastoid cells, the slopes of the dose-response curves for ASIII-induced SCEs were similar." | ( Variation in arsenic-induced sister chromatid exchange in human lymphocytes and lymphoblastoid cell lines. Menzel, DB; Rasmussen, RE, 1997) | 0.3 |
| " Dose-response experiments with melarsoprol (10(-7) to 10(-9) mol/L) were performed over 96 hours." | ( Comparative activity of melarsoprol and arsenic trioxide in chronic B-cell leukemia lines. Gabrilove, JL; Jakubowski, A; König, A; Pandolfi, PP; Rivi, R; Warrell, RP; Wrazel, L, 1997) | 0.3 |
| " Although most study subjects had stopped consuming high-arsenic artesian well water more than 20 years ago, the risk of skin cancer was found to increase significantly with cumulative arsenic exposure before the cessation of drinking artesian well water in a dose-response relationship." | ( Serum beta-carotene level, arsenic methylation capability, and incidence of skin cancer. Chen, CJ; Chen, GS; Chiou, HY; Hsueh, YM; Huang, CC; Huang, YL; Lue, LC; Wu, WL; Yang, MH, 1997) | 0.3 |
| "Circulatory diseases such as ischemic heart disease and peripheral vascular disease induced by long-term arsenic exposure have been well documented in previous studies, but the dose-response relationship between cerebrovascular disease and ingested inorganic arsenic remains to be elucidated." | ( Dose-response relationship between prevalence of cerebrovascular disease and ingested inorganic arsenic. Chang, SF; Chen, CJ; Chiou, HY; Hsu, YH; Huang, WI; Su, CL, 1997) | 0.3 |
| "A significant dose-response relationship was observed between arsenic concentration in well water and prevalence of cerebrovascular disease after adjustment for age, sex, hypertension, diabetes mellitus, cigarette smoking, and alcohol consumption." | ( Dose-response relationship between prevalence of cerebrovascular disease and ingested inorganic arsenic. Chang, SF; Chen, CJ; Chiou, HY; Hsu, YH; Huang, WI; Su, CL, 1997) | 0.3 |
| " New epidemiological studies are needed to provide data for reliable dose-response assessments of arsenic and for skin cancer, bladder cancer, or other endpoints to be used by the EPA for regulation." | ( Inorganic arsenic: a need and an opportunity to improve risk assessment. Beck, BD; Brown, KG; Chaney, R; Chappell, WR; Cothern, CR; Cothern, R; Irgolic, KJ; North, DW; Thornton, I; Tsongas, TA, 1997) | 0.3 |
| "The dose-response relationship for lung carcinoma and other cancers at low doses of As is highly uncertain because it is based on modeling data collected in populations with a high daily intake of the element." | ( Mortality by cancer in groups of the Belgian population with a moderately increased intake of arsenic. Buchet, JP; Lison, D, 1998) | 0.3 |
| "3 microgram As/m3 of air; 20-50 micrograms As/l of drinking water) does not seem to affect the causes of mortality, suggesting in particular nonlinearity of the dose-response relationship for arsenic and cancer." | ( Mortality by cancer in groups of the Belgian population with a moderately increased intake of arsenic. Buchet, JP; Lison, D, 1998) | 0.3 |
| " In order to identify individual risk in the linear dose-response relationship which would serve as a basis for the risk assessment among persons exposed occupationally, the author also analysed the latest epidemiological studies performed in Sweden, as well as repeated analyses of American studies." | ( [A quantitative assessment of health risk induced by occupational exposure to inorganic arsenic]. Szymczak, W, 1997) | 0.3 |
| " When females were dosed chronically for periods that included pregnancy, the primary effect of arsenic on reproduction was a dose-dependent increase in conceptus mortality and in postnatal growth retardation." | ( Developmental and reproductive toxicity of inorganic arsenic: animal studies and human concerns. Baumrind, N; Golub, MS; Macintosh, MS, ) | 0.13 |
| " Up to two fold increases of urinary ASi excretion in rats compared with control rats were also observed in animals dosed with various forms of arsenicals." | ( Speciation of arsenic metabolites in the urine of occupational workers and experimental rats using an optimised hydride cold-trapping method. Chiswell, B; Imray, P; Johnson, D; Moore, MR; Ng, JC, 1998) | 0.3 |
| "Studies in Taiwan have found dose-response relations between arsenic ingestion from drinking water and cancers of the skin, bladder, lung, kidney and liver." | ( Lung and kidney cancer mortality associated with arsenic in drinking water in Córdoba, Argentina. Biggs, ML; Hopenhayn-Rich, C; Smith, AH, 1998) | 0.3 |
| " We have measured the dose-response for arsenic inhibition of several purified human DNA repair enzymes, including DNA polymerase beta, DNA ligase I and DNA ligase III and have found that most enzymes, even those with critical SH groups, are very insensitive to As." | ( Arsenic toxicity is enzyme specific and its affects on ligation are not caused by the direct inhibition of DNA repair enzymes. Hu, Y; Snow, ET; Su, L, 1998) | 0.3 |
| " Findings were similar for hyperpigmentation, with strong dose-response relationships." | ( Arsenic levels in drinking water and the prevalence of skin lesions in West Bengal, India. Chakraborty, D; De, BK; Ghosh, N; Guha Mazumder, DN; Haque, R; Santra, A; Smith, AH, 1998) | 0.3 |
| " Animals were dosed topically with 'test article'--neat HD, 10% agent/chloroform solutions or product solutions (waste-streams) from neutralized CAIS--and evaluated for skin-damaging effects (gross and microscopic)." | ( Evaluation of neutralized chemical agent identification sets (CAIS) for skin injury with an overview of the vesicant potential of agent degradation products. Hayes, TL; MacIver, B; Menton, RG; Miller, TL; Olajos, EJ; Olson, CT; Rosso, T; Salem, H; Singer, AW, ) | 0.13 |
| " Therefore, using multiple variables to describe an exposure in ecologic studies may facilitate a better description of the exposure status and thereby lead to more accurate risk assessment, especially when the dose-response relationship is not linear." | ( Using ecological data to estimate a regression model for individual data: the association between arsenic in drinking water and incidence of skin cancer. Guo, HR; Hu, H; Lipsitz, SR; Monson, RR, 1998) | 0.3 |
| " A significant reverse dose-response relationship with arsenic-related ISHD was observed for serum level of alpha- and beta-carotene, but not for serum levels of retinol, lycopene and alpha-tocopherol." | ( Low serum carotene level and increased risk of ischemic heart disease related to long-term arsenic exposure. Chen, CJ; Chiou, HY; Hsueh, YM; Huang, YL; Tseng, CH; Wu, WL, 1998) | 0.3 |
| " The indicated dose-response relationships were significant (P<<0." | ( Hypertension and arsenic exposure in Bangladesh. Ahmad, SA; Axelson, O; Chowdhury, IA; Faruquee, MH; Rahman, M; Tondel, M, 1999) | 0.3 |
| " There was a close relationship between nitric oxide and anomalies in fetal development, with a dose-response pattern, showed by inducible nitric oxide synthetase (iNOS) histochemical examinations." | ( [Teratogenic effects of arsenic on rats]. Li, Y; Pan, Y; Zhu, H, 1998) | 0.3 |
| "12 rev/microgram of that with rat liver homogenate (+S9), with an obvious dose-response relationship." | ( [Studies on mutagenicity of humic acid samples collected from arsenosis-affected areas in China]. Hong, Q; Yu, X; Zheng, B, 1998) | 0.3 |
| " Induction of apoptosis in arsenic-treated Meg-01 and UT7 cells was accompanied by a dose-response decrease of Bcl-2 protein, whereas As2O3 had no effect on this measurement in HL60, ZR75, and MCF7 cell lines." | ( Effect of arsenic trioxide on viability, proliferation, and apoptosis in human megakaryocytic leukemia cell lines. Alemany, M; Caen, JP; Han, ZC; Levin, J; Lu, M; Sequeira-Le Grand, A; Sulpice, E, 1999) | 0.3 |
| " In order to address these outstanding issues, further efforts are required to identify an appropriate animal model to elucidate carcinogenic mechanisms of action, and to define dose-response relationships." | ( The enigma of arsenic carcinogenesis: role of metabolism. Aposhian, HV; Beck, BD; Cebrián, M; Goering, PL; Mass, MJ; Waalkes, MP, 1999) | 0.3 |
| " An age-dependent difference in the concentration of As in urine may be attributed to the higher As dosage rate per unit body weight in children than in adults." | ( Excretion of arsenic in urine as a function of exposure to arsenic in drinking water. Calderon, RL; Hudgens, E; Le, XC; Schreinemachers, D; Thomas, DJ, 1999) | 0.3 |
| " This study shows a higher prevalence rate of arsenic skin lesions in males than females, with clear dose-response relationship." | ( The relationship of arsenic levels in drinking water and the prevalence rate of skin lesions in Bangladesh. Ahmad, SA; Chowdhury, IA; Faruquee, MH; Magnuson, A; Rahman, M; Tondel, M, 1999) | 0.3 |
| " Most of these studies involved treatment of limited numbers of animals with maternally toxic doses of arsenic (generally As(V)), without defining a dose-response relationship." | ( Comparative effects of single intraperitoneal or oral doses of sodium arsenate or arsenic trioxide during in utero development. Farr, CH; Fleeman, TL; Holson, JF; Nemec, MD; Stump, DG, 1999) | 0.3 |
| " Recent Canadian analyses, however, based on the mortality follow-up of Tacoma smelter workers from 1940-1976, provided strong evidence of a nonlinear dose-response when lung cancer risk was expressed in terms of the standardized mortality ratio." | ( Nonlinearity in the lung cancer dose-response for airborne arsenic: apparent confounding by year of hire in evaluating lung cancer risks from arsenic exposure in Tacoma smelter workers. Silvers, A; Viren, J, 1999) | 0.3 |
| " Dose-response studies of arsenite showed substantial HO induction in liver at doses of 30 micromol/kg and higher and in the kidney at doses of 100 micromol/kg and higher." | ( An integrated pharmacokinetic and pharmacodynamic study of arsenite action. 1. Heme oxygenase induction in rats. Anderson, WL; Brown, JL; Del Razo, LM; Kenyon, EM; Kitchin, KT, 1999) | 0.3 |
| " An increased mutant frequency was observed in the highly exposed group, but the response was so slight that it is not likely that this assay will be capable of providing dose-response information across a range of lower, more typical environmental arsenic levels." | ( Effects of arsenic exposure on the frequency of HPRT-mutant lymphocytes in a population of copper roasters in Antofagasta, Chile: a pilot study. Cabrera, M; Collard, DD; Doerr, CL; Fuscoe, JC; Harrington-Brock, K; McConnell, R; Moore, MM; Sandoval, H, 1999) | 0.3 |
| " The results revealed that arsenic inhibited markedly both proliferation and differentiation of rat limb bud cells in vitro and there was an obvious dose-response relationship." | ( [Influence of arsenic on proliferation and differentiation of rat bud cells in vitro]. Kong, P; Li, Y; Zhu, H, 1998) | 0.3 |
| " From the present study, the toxic potency of these particles was provisionally estimated to be in the following order: InAs > GaAs > As2O3, at the dosage level used in this study." | ( Comparative study of the toxic effects of gallium arsenide, indium arsenide and arsenic trioxide following intratracheal instillations to the lung of Syrian golden hamsters. Gotoh, K; Hirata, M; Inoue, N; Makita, Y; Omura, M; Tanaka, A; Yamazaki, K; Zhao, M, 2000) | 0.31 |
| " While the uncertainty linked to the statistical inferences leading to the guideline are reduced by the fact that they are directly estimated from human data and result from extrapolations made relatively close to observed exposure levels, developed guideline depends strongly on the choice of the dose-response model (linear, quadratic, hockey-stick) and the accuracy of the exposure data." | ( Clues and uncertainties in the risk assessment of arsenic in drinking water. Buchet, J; Lison, D, 2000) | 0.31 |
| " On the basis of its high degree of toxicity to humans, and the non-threshold dose-response assumption, a zero level exposure is recommended for arsenic, even though this level is practically non-attainable." | ( Important considerations in the development of public health advisories for arsenic and arsenic-containing compounds in drinking water. Ishaque, A; Tchounwou, PB; Wilson, B, ) | 0.13 |
| " The median duration to CR ranged from 38 to 51 days, with accumulative As2O3 dosage of 340-430 mg." | ( Arsenic trioxide therapy for relapsed acute promyelocytic leukemia: an useful salvage therapy. Chen, YC; Huan, SY; Yang, CH, 2000) | 0.31 |
| " A significant dose-response relation between risk of cancers of the urinary organs, especially TCC, and indices of arsenic exposure was observed after adjustment for age, sex, and cigarette smoking." | ( Incidence of transitional cell carcinoma and arsenic in drinking water: a follow-up study of 8,102 residents in an arseniasis-endemic area in northeastern Taiwan. Chen, CJ; Chiou, HY; Chiou, ST; Chou, YL; Hsu, YH; Tseng, CH; Wei, ML, 2001) | 0.31 |
| " Based upon epidemiological evidence and mechanistic studies, it has been argued that a non-linear dose-response model at low-level exposures is more appropriate for calculating risk than the more commonly employed linear-response models." | ( Quantitative relationship between arsenic exposure and AP-1 activity in mouse urinary bladder epithelium. Crecelius, E; Kashon, ML; Kommineni, C; Luster, MI; Simeonova, PP; Wang, S, 2001) | 0.31 |
| "The aim of this study was to determine the dosage and the compounds of arsenic that induce fatty liver in mule ducks and also to investigate their effects on tissue residues." | ( Oral treatment of mule ducks with arsenicals for inducing fatty liver. Chen, KL; Chiout, PW, 2001) | 0.31 |
| " Because of the indirect mode of action, it has been discussed as well that As's genotoxicity may underlie a sublinear dose-response relationship." | ( Genotoxicity of arsenical compounds. Gebel, TW, 2001) | 0.31 |
| " In risk assessment of environmental arsenic, it is important to know and to utilize both the mode of carcinogenic action and the shape of the dose-response curve at low environmental arsenic concentrations." | ( Recent advances in arsenic carcinogenesis: modes of action, animal model systems, and methylated arsenic metabolites. Kitchin, KT, 2001) | 0.31 |
| " In conclusion, we demonstrated that low-dose As2O3 had the same effect as the conventional dosage and the mechanism of low-dose arsenic seemed to primarily induce differentiation of APL cells." | ( Studies on the clinical efficacy and pharmacokinetics of low-dose arsenic trioxide in the treatment of relapsed acute promyelocytic leukemia: a comparison with conventional dosage. Chen, J; Chen, SJ; Chen, Z; Li, JM; Li, XS; Liu, YF; Niu, C; Shen, Y; Shen, ZX; Tang, W; Wang, ZY; Wu, F; Wu, W; Xiong, SM; Yan, H; Zeng, XY; Zhao, WL, 2001) | 0.31 |
| " As part of a program for assessment of the quality of herbal medicines, we have analyzed 21 over-the-counter ginseng (Panax ginseng) products in various dosage forms." | ( Determination of heavy metals and pesticides in ginseng products. Abourashed, EA; Allgood, J; Benson, WH; Khan, IA; Schlenk, D; Walker, LA, ) | 0.13 |
| " Advances in methodology include the use of nested dose-response models for the parameters of the two-stage clonal expansion model, calculation of attributable risks for all exposure combinations, use of both a fixed lag and a gamma distribution to represent the time between generation of the first malignant cell and death from lung cancer, and scaling of biological parameters allowed by parameter identifiability." | ( Analysis of a historical cohort of Chinese tin miners with arsenic, radon, cigarette smoke, and pipe smoke exposures using the biologically based two-stage clonal expansion model. Hazelton, WD; Heidenreich, WF; Luebeck, EG; Moolgavkar, SH, 2001) | 0.31 |
| " Given the considerable interest in the dose-response relationships for arsenic as a toxin and a carcinogen, understanding the metabolism of arsenic may be critical to assessing the risk associated with chronic exposure to this element." | ( The cellular metabolism and systemic toxicity of arsenic. Lin, S; Styblo, M; Thomas, DJ, 2001) | 0.31 |
| " Comparison of males and females in the same households confirmed that skin manifestations were more severe in the males, and in the males of one community a dose-response relationship between [As](u) and the degree of skin manifestation was evident." | ( Males in rural Bangladeshi communities are more susceptible to chronic arsenic poisoning than females: analyses based on urinary arsenic. Inaoka, T; Kadono, T; Miyazaki, K; Murayama, N; Nagano, M; Nakamura, S; Ohtsuka, R; Ushijima, K; Watanabe, C, 2001) | 0.31 |
| " In the present study each treatment group was exposed to a combination of one of three doses of As (0, 100, or 1000 microg As/g) and one of two types of diet, no brine shrimp (NS) or with brine shrimp (WS) for a total of eight dosing events." | ( The accumulation, distribution, and toxicological effects of dietary arsenic exposure in lake whitefish (Coregonus clupeaformis) and lake trout (Salvelinus namaycush). Baron, CL; Evans, RE; Klaverkamp, JF; Pedlar, RM; Ptashynski, MD; Wautier, KG, 2002) | 0.31 |
| " In rats dosed with 5 mg As(III)/kg, the increases (expressed as % of the control values) of protoporphyrin IX in the blood were in the order: sodium arsenite (144%) > sodium arsenate (125%) > calcium arsenite (123%) > calcium arsenate." | ( Porphyrin profiles in blood and urine as a biomarker for exposure to various arsenic species. Moore, MR; Ng, JC; Qi, L, 2002) | 0.31 |
| "Long-term exposure to ingested arsenic has been documented to induce peripheral vascular disease, ischemic heart disease, and cerebral infarction in a dose-response relationship." | ( Biological gradient between long-term arsenic exposure and carotid atherosclerosis. Chen, CJ; Chen, CL; Chiou, HY; Hsu, LI; Hsueh, YM; Jeng, JS; Wang, CH; Wu, MM; Yip, PK, 2002) | 0.31 |
| " Three indices of long-term exposure to ingested arsenic, including the duration of consuming artesian well water, the average arsenic concentration in consumed artesian well water, and cumulative arsenic exposure, were all significantly associated with prevalence of carotid atherosclerosis in a dose-response relationship." | ( Biological gradient between long-term arsenic exposure and carotid atherosclerosis. Chen, CJ; Chen, CL; Chiou, HY; Hsu, LI; Hsueh, YM; Jeng, JS; Wang, CH; Wu, MM; Yip, PK, 2002) | 0.31 |
| " Epidemiological studies confirmed a dose-response relationship between long-term arsenic exposure and the occurrence of blackfoot disease." | ( Peripheral vascular diseases resulting from chronic arsenical poisoning. Chen, GS; Lee, CH; Yu, HS, 2002) | 0.31 |
| " In contrast, FA of flies reared at sub-lethal dosage did not differ from that in controls, a result that fails to support the hypothesis that arsenite disrupts developmental stability." | ( Response of fluctuating asymmetry to arsenic toxicity: support for the developmental selection hypothesis. Cartwright, IL; Opoka, R; Polak, M, 2002) | 0.31 |
| " Therefore, we are conducting a population-based epidemiologic study in New Hampshire (1) to assess the risk of skin and bladder cancer associated with arsenic exposure in a US population, (2) to evaluate methods of quantifying individual exposure to arsenic at low to moderate levels, and (3) to explore alternative models of determining the dose-response relationship at the lower end of exposure." | ( Assessment of cancer risk and environmental levels of arsenic in New Hampshire. Karagas, MR; Stukel, TA; Tosteson, TD, 2002) | 0.31 |
| "5% the in vivo bioavailability of As in nine contaminated soils previously used in swine dosing trials." | ( Adsorption, sequestration, and bioaccessibility of As(V) in soils. Barnett, MO; Basta, NT; Casteel, SW; Jardine, PM; Yang, JK, 2002) | 0.31 |
| " dosing was taken to be 100% and that attributed to oral dosing (day 2) was then calculated." | ( Systemic availability of arsenic from oral arsenic-trioxide used to treat patients with hematological malignancies. Au, WY; Kou, M; Kumana, CR; Kwong, YL; Lam, CW; Lee, NS; Mak, RW, 2002) | 0.31 |
| "Respective day-2 mean plasma and blood AUCs attributed to oral dosing were 99% and 87% of corresponding day-1 values." | ( Systemic availability of arsenic from oral arsenic-trioxide used to treat patients with hematological malignancies. Au, WY; Kou, M; Kumana, CR; Kwong, YL; Lam, CW; Lee, NS; Mak, RW, 2002) | 0.31 |
| " Overexpression of NCS-1 caused a shift in the dose-response curve of inhibition of ATP-evoked secretion using phenylarsine oxide, an inhibitor of phosphatidylinositol 4-OH kinase (PI4K)." | ( Phosphatidylinositol 4-OH kinase is a downstream target of neuronal calcium sensor-1 in enhancing exocytosis in neuroendocrine cells. Greenwood, S; Hilfiker, S; Jeromin, A; Rajebhosale, M; Vidugiriene, J, 2003) | 0.32 |
| " The potentiation of apoptosis was dependent on the dosage of CDA-II." | ( Synergistic effect of cell differential agent-II and arsenic trioxide on induction of cell cycle arrest and apoptosis in hepatoma cells. Liu, JW; Shen, Y; Tang, Y; Zhong, XY, 2003) | 0.32 |
| "Rats were given Realgar with dosage of 50, 150, 450 mg." | ( [Influence of oral administration of realgar on contents of copper, zinc and selenium in rat tissues]. Bao, SF; Cheng, ZJ; Cong, T; Li, Z; Tian, H; Zhao, L, 2001) | 0.31 |
| " But higher dosage (450 mg." | ( [Influence of oral administration of realgar on contents of copper, zinc and selenium in rat tissues]. Bao, SF; Cheng, ZJ; Cong, T; Li, Z; Tian, H; Zhao, L, 2001) | 0.31 |
| " The dosage of As2O3 used was 2 mg/kg." | ( [Effect of arsenic trioxide on apoptosis of pulmonary eosinophile in asthmatic guinea-pigs]. Yin, KS; Zhou, LF, 2002) | 0.31 |
| " As mechanisms for the reduced methylation efficiency, the saturation of the enzymatic process of arsenic methylation, the high dosage of antidote DMPS, which might inhibit the activity of the methyl transferases, and analytical reasons are discussed." | ( Arsenic species excretion after dimercaptopropanesulfonic acid (DMPS) treatment of an acute arsenic trioxide poisoning. Angerer, J; Heinrich-Ramm, R; Horn, J; Schaller, H, 2003) | 0.32 |
| " The key objective of this nested case-control study was to characterize the dose-response relation between low arsenic concentrations in drinking water and arsenic-induced skin keratoses and hyperpigmentation." | ( Arsenic in drinking water and skin lesions: dose-response data from West Bengal, India. Das, S; De, BK; Ghosh, N; Haque, R; Kalman, D; Lahiri, S; Mazumder, DN; Mitra, S; Samanta, S; Santra, A; Smith, AH; Smith, MM, 2003) | 0.32 |
| " We found strong dose-response gradients with both peak and average arsenic water concentrations." | ( Arsenic in drinking water and skin lesions: dose-response data from West Bengal, India. Das, S; De, BK; Ghosh, N; Haque, R; Kalman, D; Lahiri, S; Mazumder, DN; Mitra, S; Samanta, S; Santra, A; Smith, AH; Smith, MM, 2003) | 0.32 |
| " Confirmation of case diagnosis and intensive longitudinal exposure assessment provide the basis for a detailed dose-response evaluation of arsenic-caused skin lesions." | ( Arsenic in drinking water and skin lesions: dose-response data from West Bengal, India. Das, S; De, BK; Ghosh, N; Haque, R; Kalman, D; Lahiri, S; Mazumder, DN; Mitra, S; Samanta, S; Santra, A; Smith, AH; Smith, MM, 2003) | 0.32 |
| " These results suggest that As2O3 at a high dosage (5 micromol/l) causes cell apoptosis and at a low dosage (0." | ( Reactive oxygen species and antioxidants in apoptosis of esophageal cancer cells induced by As2O3. Chen, MH; Shen, J; Shen, WY; Shen, ZY; Zeng, Y, 2003) | 0.32 |
| " Thus, before hair analysis can be considered a valid tool for assessing exposure and health impact of a particular substance, research is needed to establish standardized reference ranges, gain a better understanding of biologic variations of hair growth with age, gender, race and ethnicity, and pharmacokinetics, and further explore possible dose-response relationships." | ( Hair analysis: exploring the state of the science. Harkins, DK; Susten, AS, 2003) | 0.32 |
| " Arsenic extracted by five commonly used soil extractants was compared with bioavailable arsenic measured in vivo by immature swine (Sus scrofa) dosing trials." | ( Chemical extraction methods to assess bioavailable arsenic in soil and solid media. Armstrong, FP; Basta, NT; Casteel, SW; Rodriguez, RR; Ward, DC, ) | 0.13 |
| " In order to meet the arsenic leaching standard of the toxicity characteristic leaching procedure (TCLP), an extremely high cement dosage is required in the S/S process (cement/waste weight ratio>6)." | ( Arsenic contaminated site at an abandoned copper smelter plant: waste characterization and solidification/stabilization treatment. Lin, CF; Shih, CJ, 2003) | 0.32 |
| " When cases treated with "adequate" dosage of arsenic and bismuth are analysed by the same statistical method as that employed in evaluating penicillin, the superiority of penicillin is clearly evident." | ( Long-term studies of results of penicillin therapy in early syphilis. PRICE, EV; SHAFER, JK; USILTON, LJ, 1954) | 0.23 |
| " When both lateral tumors had grown to about 10x8x5 mm(3), the right tumors were treated with an intratumoral injection of As2O3 in dosage of 1, 5 and 10 microg per day, respectively, for 10 days sequentially." | ( The inhibition of growth and angiogenesis in heterotransplanted esophageal carcinoma via intratumoral injection of arsenic trioxide. Chen, MH; Shen, J; Shen, ZY; Wu, MH; Wu, XY; Zeng, Y, ) | 0.13 |
| " Some recommended measures of the economic benefits associated with environmental regulations are sensitive to the timing of the risk reductions and cannot be effectively addressed by the conventional dose-response procedures." | ( Procedures for calculating cessation lag. Chen, CW; Gibb, H, 2003) | 0.32 |
| " Other possible explanations may relate to strain-specific differences, or to the different durations of dosing in each of the mouse studies, given the evidence that inorganic arsenic is likely to be active in the later stages of the carcinogenic process." | ( Physiologically based pharmacokinetic modeling of arsenic in the mouse. Clewell, HJ; Covington, TR; Gentry, PR; Mann, S; Shipp, AM; Yager, JW, 2004) | 0.32 |
| " Data obtained from the MTT assay indicated a strong dose-response relationship with respect to arsenic trioxide toxicity." | ( Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2). Dorsey, WC; Tchounwou, PB; Yedjou, CG, 2003) | 0.32 |
| "To investigate cardiac effects of arsenic trioxide (As(2)O(3)) at conventional dosage in acute promyelocytic leukemia (APL) patients." | ( [Clinical and experimental study of cardiac effects of conventional dosage arsenic trioxide in APL patients]. Li, BX; Liu, Y; Meng, R; Wang, W; Yang, BF; Zhou, J, 2004) | 0.32 |
| "Lung cancers have been observed among patients of arsenic intoxication since the 1950s, but data on the dose-response relationship were limited." | ( Arsenic level in drinking water and mortality of lung cancer (Taiwan). Guo, HR, 2004) | 0.32 |
| " Post-hoc analyses confirmed such a dose-response relationship." | ( Arsenic level in drinking water and mortality of lung cancer (Taiwan). Guo, HR, 2004) | 0.32 |
| " Specific dose-response information is often lacking." | ( Occupation and lung cancer in nonsmokers. Field, RW; Neuberger, JS, ) | 0.13 |
| "The blood concentrations of mercury and arseic reached the highest point in normal rats at one hour following single oral dosing of Angong Niuhuang pill." | ( [Absorption and distribution of mercury and arsenic from realgar and cinnabar of angong niuhuang pill in normal rats and rats with cerebral ischemia]. Huang, N; Jin, AY; Li, CY; Liang, AH; Wang, JH; Wang, L; Wang, YS; Wang, ZM; Xue, BY; Ye, ZG; Zhang, J, 2003) | 0.32 |
| " Blackfoot disease (BFD) caused by arsenicosis is endemic in southwestern Taiwan, where artesian well water contains high concentrations of arsenic, and mortality from HCC shows a dose-response increase by concentration of arsenic in the well water." | ( Characteristics of hepatocellular carcinoma in a high arsenicism area in Taiwan: a case-control study. Carr, BI; Chang, TT; Chen, SC; Chow, NH; Huang, WS; Lin, CH; Lu, SN; Wu, WC, 2004) | 0.32 |
| " It has been suggested that axonal degeneration and segmental demyelination might be equally prominent pathological features of the neuropathy, depending on the dosage and the length of time of exposure to arsenic." | ( [Acute polyneuropathy and encephalopathy caused by arsenic poisoning]. Berbel-García, A; Botia-Paniagua, E; Gil-Madre, J; González-Aguirre, JM; López-Zuazo, I; Orts-Castro, E; Rodríguez-García, JL, ) | 0.13 |
| " High dosage of arsenic sulfide can slightly induce differentiation of HL-60 cells." | ( [Changes of telomerase activity and hTERT mRNA expression in the process of apoptosis of HL-60 cells induced by arsenic sulfide]. Li, J; Liu, SX, 2003) | 0.32 |
| " In this paper, epidemiological studies conducted on the dose-response relationships between iAs exposure via the drinking water and related adverse health effects are reviewed." | ( Chronic health effects in people exposed to arsenic via the drinking water: dose-response relationships in review. Fan Sun, G; Yamauchi, H; Yoshida, T, 2004) | 0.32 |
| " UROtsa cell ability to biotransform As(III) was determined by dosing cells with environmentally relevant concentrations of As(III) followed by HPLC/ICP-MS analysis of cell media and lysate." | ( Effects of arsenite on UROtsa cells: low-level arsenite causes accumulation of ubiquitinated proteins that is enhanced by reduction in cellular glutathione levels. Bredfeldt, TG; Gandolfi, AJ; Kopplin, MJ, 2004) | 0.32 |
| " The blood and organ concentrations of the arsenic species, including As(III), dimethylarsinic acid (DMA), and monomethylarsonic acid (MMA), were studied on day 1 (single-dose study), day 30 (multiple dosing study), and day 60 (reversibility study)." | ( Tissue distribution of arsenic species in rabbits after single and multiple parenteral administration of arsenic trioxide: tissue accumulation and the reversibility after washout are tissue-selective. Cheng, AL; Hsueh, YM; Lin, CJ; Sun, SS; Wu, MH, 2005) | 0.33 |
| " All detectable arsenic species showed strong linear correlation with administered dosage and the arsenic methylation patterns were similar in all three treatment groups." | ( Urinary arsenic speciation and porphyrins in C57Bl/6J mice chronically exposed to low doses of sodium arsenate. Huang, SH; Lam, PK; Manonmanii, K; Ng, JC; Wang, JP; Wu, H, 2004) | 0.32 |
| " We kinetically linked an Area-under-the-curve (AUC)-based acute toxicity model and a pharmacodynamic model to derive dose-response relationships between equilibrium organ-specific arsenic concentrations and mortality effects." | ( Organ-specific toxicokinetics and dose-response of arsenic in tilapia Oreochromis mossambicus. Chou, YH; Liang, HM; Liao, CM; Ling, MP; Tsai, JW; Yang, PT, 2004) | 0.32 |
| " Long-term arsenic exposure has also been reported to associated with lung cancer mortality in a dose-response relationship." | ( Lung cancer mortality reduction after installation of tap-water supply system in an arseniasis-endemic area in Southwestern Taiwan. Chiu, HF; Ho, SC; Yang, CY, 2004) | 0.32 |
| " Estimates of daily metal ingestion for adults and children estimated using manufacturers' dosage recommendations with comparisons to US Pharmacopeia and US Environmental Protection Agency regulatory standards." | ( Heavy metal content of ayurvedic herbal medicine products. Burns, MJ; Davis, RB; Eisenberg, DM; Kales, SN; Paquin, J; Phillips, RS; Saper, RB, 2004) | 0.32 |
| "To elucidate the dose-response relationship between ingested arsenic and lung cancer and to assess the effect of cigarette smoking on the arsenic-lung cancer association." | ( Ingested arsenic, cigarette smoking, and lung cancer risk: a follow-up study in arseniasis-endemic areas in Taiwan. Chen, CJ; Chen, CL; Chen, SY; Chiou, HY; Hsu, LI; Hsueh, YM; Wu, MM, 2004) | 0.32 |
| "There was a significant dose-response trend of ingested arsenic on lung cancer risk, which was more prominent among cigarette smokers." | ( Ingested arsenic, cigarette smoking, and lung cancer risk: a follow-up study in arseniasis-endemic areas in Taiwan. Chen, CJ; Chen, CL; Chen, SY; Chiou, HY; Hsu, LI; Hsueh, YM; Wu, MM, 2004) | 0.32 |
| " Peak concentrations of DMA in kidney were achieved at 2 h post dosing for both dose levels." | ( Tissue distribution and urinary excretion of inorganic arsenic and its methylated metabolites in mice following acute oral administration of arsenate. Del Razo, LM; Hughes, MF; Kenyon, EM, 2005) | 0.33 |
| " The present study has been carried out to find out whether increased oxystress and cytokine response are associated with increased accumulation of collagen in the liver due to prolonged arsenic exposure and these follow a dose-response relationship." | ( Implications of oxidative stress and hepatic cytokine (TNF-alpha and IL-6) response in the pathogenesis of hepatic collagenesis in chronic arsenic toxicity. Das, S; Guha Mazumder, DN; Lahiri, S; Santra, A, 2005) | 0.33 |
| " The literature on the dose-response relationship between arsenic exposure and MCC is limited." | ( Merkel cell carcinoma in patients with long-term ingestion of arsenic. Guo, HR; Ho, SY; Lee, MC; Tsai, YC, 2005) | 0.33 |
| "The Microtox bioassay was used to establish dose-response curves for some toxic elements in aqueous solutions, namely, Zn(II), Pb(II), Cu(II), Hg(II), Ag(I), Co(II), Cd(II), Cr(VI), As(V) and As(III)." | ( Patterns of metals and arsenic poisoning in Vibrio fischeri bacteria. Fulladosa, E; Martínez, M; Murat, JC; Villaescusa, I, 2005) | 0.33 |
| " Further studies are necessary to verify the hypotheses of threshold or dose-response relationships." | ( Arsenic ingestion and increased microvascular disease risk: observations from the south-western arseniasis-endemic area in Taiwan. Chen, CJ; Chiou, JM; Deng, CR; Lin, W; Tai, TY; Wang, SL, 2005) | 0.33 |
| " Continual exposure of arsenic trioxide, at the clinic achievable dosage that does not induce apoptosis, suppressed 3T3-L1 cell differentiation into fat cells by inhibiting the expression of PPARgamma and C/EBPalpha and disrupting the interaction between PPARgamma and RXRalpha, which determines the programming of the adipogenic genes." | ( The role of Akt on arsenic trioxide suppression of 3T3-L1 preadipocyte differentiation. Chen, Q; Jiang, CS; Jin, HJ; Liu, L; Wang, XH; Wang, ZX; Wu, Q, 2005) | 0.33 |
| " The effects of solution pH, contact time, arsenic concentration and adsorbent dosage on arsenic removal were examined and the optimum removal conditions were established." | ( Iron oxide-loaded slag for arsenic removal from aqueous system. Itoh, H; Zhang, FS, 2005) | 0.33 |
| " In G-area, there was a clear dose-response pattern both in relation to UTAs and UCd for each of the biomarkers of renal dysfunction." | ( Biomarkers of cadmium and arsenic interactions. Bernard, A; Buchet, JP; Hong, F; Jin, T; Nordberg, GF; Zhang, A, 2005) | 0.33 |
| "Long-term exposure to inorganic arsenic from drinking water has been documented to induce cancers and vascular diseases in a dose-response relationship." | ( Biomarkers of exposure, effect, and susceptibility of arsenic-induced health hazards in Taiwan. Chen, CJ; Chen, CL; Chen, CY; Chen, SY; Cheng, YC; Chiou, HY; Chou, WL; Hsu, LI; Hsu, YH; Hsueh, YM; Lee, CY; Lin, YC; Shih, WL; Tseng, MP; Wang, CH; Wang, LH; Wang, YH; Wu, MM, 2005) | 0.33 |
| " Furthermore, our data demonstrated the presence of a threshold for the non-genotoxic carcinogen, phenobarbital (PB), and the lack of linearity in the low-dose area of the dose-response curve, providing evidence for hormesis." | ( Current and emerging challenges in toxicopathology: carcinogenic threshold of phenobarbital and proof of arsenic carcinogenicity using rat medium-term bioassays for carcinogens. Fukushima, S; Kinoshita, A; Morimura, K; Salim, EI; Wanibuchi, H, 2005) | 0.33 |
| " Arsenic (As) dosage in pore water shows that a change in its bioavailability occurs that may explain the surprising toxicity results." | ( Unexpected reduction in reproduction of Collembola exposed to an arsenic-contaminated soil. Cazes, L; Crouau, Y, 2005) | 0.33 |
| "A community-based, dose-response study on arsenic contamination was conducted in three communities in Terai in lowland Nepal." | ( Arsenic contamination in drinking water and skin manifestations in lowland Nepal: the first community-based survey. Ahmad, SA; Maharjan, M; Ohtsuka, R; Watanabe, C, 2005) | 0.33 |
| " This model was also able to predict the in vivo bioavailability of As in contaminated soils previously used in an independent juvenile swine dosing trial within an RMSE of 15." | ( Adsorption, oxidation, and bioaccessibility of As(III) in soils. Barnett, MO; Fendorf, SE; Jardine, PM; Yang, JK; Zhuang, J, 2005) | 0.33 |
| " After the patient achieved CR, 1 additional ATO course at the same dosage was administered for 25 days." | ( Arsenic trioxide therapy in relapsed or refractory Japanese patients with acute promyelocytic leukemia: updated outcomes of the phase II study and postremission therapies. Fujisawa, S; Kobayashi, M; Naito, K; Nakamura, S; Ohnishi, K; Ohno, R; Sahara, N; Shigeno, K; Shinjo, K; Takeshita, A, 2005) | 0.33 |
| " This hypermethylation showed a dose-response relationship." | ( DNA hypermethylation of promoter of gene p53 and p16 in arsenic-exposed people with and without malignancy. Chanda, S; Chatterjee, D; Chaudhuri, U; Das, S; Dasgupta, UB; Ghosh, N; Guhamazumder, D; Gupta, M; Lahiri, S, 2006) | 0.33 |
| " Long-term arsenic exposure has been associated with kidney cancer mortality in a dose-response relationship." | ( Reduction in kidney cancer mortality following installation of a tap water supply system in an arsenic-endemic area of Taiwan. Chiu, HF; Chuang, HY; Ho, SC; Wu, TN; Yang, CY, 2004) | 0.32 |
| " After adjustment for sociodemographic covariates, water Mn was associated with reduced Full-Scale, Performance, and Verbal raw scores, in a dose-response fashion; the low level of As in water had no effect." | ( Water manganese exposure and children's intellectual function in Araihazar, Bangladesh. Ahsan, H; Cheng, Z; Factor-Litvak, P; Graziano, JH; Kline, J; Levy, D; Liu, X; LoIacono, NJ; Parvez, F; Slavkovich, V; van Geen, A; Wasserman, GA; Zheng, Y, 2006) | 0.33 |
| " We employed the Hill equation model to predict the organ-specific dose-response relationships." | ( A dose-based modeling approach for accumulation and toxicity of arsenic in tilapia Oreochromis mossambicus. Liao, CM; Tsai, JW, 2006) | 0.33 |
| " This review deals with the questions raised in the epidemiological studies such as the dose-response relationship, putative confounders and synergistic effects, and methods evaluating arsenic exposure." | ( Arsenic in the aetiology of cancer. Grosche, B; Tapio, S, 2006) | 0.33 |
| " The authors evaluated dose-response relations between arsenic exposure from drinking water and premalignant skin lesions by using baseline data on 11,746 participants recruited in 2000-2002 for the Health Effects of Arsenic Longitudinal Study in Araihazar, Bangladesh." | ( Arsenic exposure from drinking water and risk of premalignant skin lesions in Bangladesh: baseline results from the Health Effects of Arsenic Longitudinal Study. Ahsan, H; Argos, M; Chen, Y; Cheng, Z; Graziano, JH; Howe, GR; Hussain, I; Levy, D; Momotaj, H; Parvez, F; Slavkovich, V; van Geen, A; Zablotska, L, 2006) | 0.33 |
| " The models implemented included a physiologically based toxicokinetic and toxicodynamic (PBTK/TD) model to account for As exposure and dose-response profiles in tilapia and a human health exposure/risk model that accounts for target lifetime risk (TR) and hazard quotient (HQ) for humans consuming farmed tilapia." | ( A PBTK/TD modeling-based approach can assess arsenic bioaccumulation in farmed tilapia (Oreochromis mossambicus) and human health risks. Chen, BC; Liao, CM; Ling, MP; Tsai, JW, 2005) | 0.33 |
| " Furthermore, the evidence strongly supports a nonlinear dose-response relationship for the biologic processes involved in the carcinogenicity of arsenicals." | ( Methylated arsenicals: the implications of metabolism and carcinogenicity studies in rodents to human risk assessment. Arnold, LL; Beck, BD; Cohen, SM; Eldan, M; Lewis, AS, 2006) | 0.33 |
| "1 x 10(-5) M) as NH3, >75% As(III) oxidation could be achieved within 10 s of dosing 1-2 mg/L Cl2 (1." | ( Kinetics and mechanistic aspects of As(III) oxidation by aqueous chlorine, chloramines, and ozone: relevance to drinking water treatment. Ammann, A; Berg, M; Cao, TH; Dodd, MC; Kissner, R; Le, VC; Pham, HV; Von Gunten, U; Vu, ND, 2006) | 0.33 |
| " Tissues were collected from three females and from associated fetuses exposed to each dosage level." | ( Arsenicals in maternal and fetal mouse tissues after gestational exposure to arsenite. Adair, BM; Devesa, V; Diwan, BA; Liu, J; Styblo, M; Thomas, DJ; Waalkes, MP, 2006) | 0.33 |
| " Long-term exposure to inorganic arsenic (As) from drinking water has been documented to induce cancers in lung, urinary bladder, kidney, liver and skin in a dose-response relationship." | ( Arsenic carcinogenesis in the skin. Chai, CY; Liao, WT; Yu, HS, 2006) | 0.33 |
| " In this six-township study, only three townships (2, 4, and 6) showed a significant positive dose-response relationship with arsenic exposure." | ( Arsenic cancer risk confounder in southwest Taiwan data set. Chen, R; Engel, A; Feinleib, M; Lamm, SH; Penn, CA, 2006) | 0.33 |
| " We observed consistent dose-response relationships between the risk of skin lesions and all the measures of As exposure." | ( Blood arsenic as a biomarker of arsenic exposure: results from a prospective study. Ahsan, H; Chen, Y; Graziano, J; Hall, M; Parvez, F; Slavkovich, V; van Geen, A, 2006) | 0.33 |
| " Animals were sacrificed 24h after the last dosing for various biochemical parameters." | ( Co-administration of zinc and n-acetylcysteine prevents arsenic-induced tissue oxidative stress in male rats. Flora, SJ; Kannan, GM; Kaul, RK; Modi, M, 2006) | 0.33 |
| " A consistent dose-response relationship between arsenic exposure level and skin lesion risk was observed." | ( Association between multi-level inorganic arsenic exposure from drinking water and skin lesions in China. Fujino, Y; Guo, X; Liu, J; Ye, X; Yoshimura, T, 2006) | 0.33 |
| " We reconstruct age-specific dose-response profiles for arsenicosis and arsenic-induced cancers by best fitting a pharmacodynamics-based three-parameter Hill equation model to published epidemiological data from West Bengal and Taiwan." | ( Risk characterization and exposure assessment in arseniasis-endemic areas of Taiwan. Liao, CM; Ling, MP, 2007) | 0.34 |
| " The requirement for slow dosage increases of arsenic and the time required to achieve a pharmacologic active dose in patients is a major obstacle because median survival of patients with ATL is about 6 months." | ( Emodin and DHA potently increase arsenic trioxide interferon-alpha-induced cell death of HTLV-I-transformed cells by generation of reactive oxygen species and inhibition of Akt and AP-1. Bellon, M; Brown, M; Nicot, C, 2007) | 0.34 |
| " Coproporphyrin I (Copro I) showed a significant dose-response relationship after 12, 14 and 20 months of exposure." | ( Urinary arsenic methylation and porphyrin profile of C57Bl/6J mice chronically exposed to sodium arsenate. Huang, SH; Krishnamohan, M; Lam, PK; Maddelena, R; Moore, MR; Ng, JC; Wu, HJ, 2007) | 0.34 |
| " Based on conservative dose estimates and the likelihood that arsenic's carcinogenic mechanisms follow sub-linear dose-response curves, we estimate a margin of exposure of at least 10(3)-10(4) between carcinogenic doses used in rodent studies and those expected after human consumption of large quantities of seafood." | ( Seafood arsenic: implications for human risk assessment. Borak, J; Hosgood, HD, 2007) | 0.34 |
| "Most arsenic cancer risk assessments have been based solely on epidemiological studies to characterize the dose-response relationship for arsenic-associated cancer and to perform risk calculations." | ( Inorganic arsenic in drinking water and bladder cancer: a meta-analysis for dose-response assessment. Chu, HA; Crawford-Brown, DJ, 2006) | 0.33 |
| "Cumulative arsenic exposure (CAE) from drinking water has been shown to be associated with hypertension in a dose-response pattern." | ( Arsenic methylation capability and hypertension risk in subjects living in arseniasis-hyperendemic areas in southwestern Taiwan. Chen, CJ; Hsueh, YM; Huang, YK; Huang, YL; Tseng, CH; Yang, MH, 2007) | 0.34 |
| "5) was observed for the development of slow nerve conduction velocity of the sural sensory action potential (SAP) among the study subjects with a cumulative arsenic dosage of>100." | ( Association between chronic exposure to arsenic and slow nerve conduction velocity among adolescents in Taiwan. Chen, CJ; Chiou, HY; The, HW; Tseng, HP; Wang, YH; Wu, MM, 2006) | 0.33 |
| " Less dosage and shorter course can be expected when arsenic trioxide, ginseng saponin, and beta-elemene are used in combination with CTX." | ( Effect of ginseng saponin, arsenic trioxide, beta-elemene combined with CTX on telomere-telomerase system in K562 cell line. Fang, MY; Wang, Y, 2006) | 0.33 |
| "Long-term exposure to ingested arsenic from drinking water has been well documented to be associated with an increased risk of diabetes mellitus and hypertension in a dose-response relationship among residents of arseniasis-endemic areas in southwestern Taiwan and Bangladesh." | ( Arsenic and diabetes and hypertension in human populations: a review. Chen, CJ; Chen, SY; Chiou, HY; Chiou, JM; Hsueh, YM; Lai, MS; Tseng, CH; Wang, SL; Wu, MM, 2007) | 0.34 |
| "We found a strong dose-response association with all measures of arsenic exposure and skin lesions." | ( Socioeconomic status and risk for arsenic-related skin lesions in Bangladesh. Ahsan, H; Argos, M; Chen, Y; Graziano, JH; Howe, GR; Hussain, AZ; Momotaj, H; Parvez, F, 2007) | 0.34 |
| " It may also be useful in development of biologically based dose-response models describing the toxic and carcinogenic actions of arsenicals." | ( Molecular processes in cellular arsenic metabolism. Thomas, DJ, 2007) | 0.34 |
| " Water quality data and dose-response models were used to predict disease burdens due to microbial pathogens and arsenic." | ( Disease burden estimation to support policy decision-making and research prioritization for arsenic mitigation. Ahmed, MF; Davison, A; Deere, D; Howard, G; Mahmud, SG; Teunis, P, 2007) | 0.34 |
| "The mice bearing NPCX were treated with radiation alone (2, 4, and 6 Gy), ATO alone (4 mg/kg/day x 6 days), and ATO plus radiation at the same dosage levels." | ( Synergistic therapeutic effect of arsenic trioxide and radiotherapy in BALB/C nude mice bearing nasopharyngeal carcinoma xenografts. Chen, JY; Du, CW; Hong, CQ; Li, DR; Lin, XH; Xie, LX, 2007) | 0.34 |
| " Epidemiological studies have shown that chronic arsenic poisoning through ingestion of arsenic-contaminated water is associated with various cardiovascular diseases in dose-response relationships." | ( A review of the epidemiologic literature on the role of environmental arsenic exposure and cardiovascular diseases. Chen, CJ; Chen, CL; Chen, SY; Chiou, HY; Hsiao, CK; Hsu, LI; Hsueh, YM; Wang, CH; Wu, MM, 2007) | 0.34 |
| " The implications of the dose-response for arsenic exposure for risk estimation merit further consideration." | ( Lung cancer mortality at a UK tin smelter. Atkin, P; Batlle, JV; Holroyd, C; Jones, SR; Lutman, E; Wakeford, R; Walker, P, 2007) | 0.34 |
| "With the different dosage of hydroxypropyl methyl cellulose (HPMC) as the tablets frame matrix, uniform design and correlation analysis were used to optimize the best component proportions of formula, and to measure the dissolution of the tablets in vitro." | ( [Optimization of formulation matrix proportion and preparation technology of realgar floating tablets for gastric retention by uniform design and correlation analysis]. Chen, XL; Lin, YP; Qi, FY; Yang, CF; Zhong, YP, 2007) | 0.34 |
| " Some IVG procedures have incorporated a dosing vehicle (DV) or food (i." | ( The effect of dosing vehicle on arsenic bioaccessibility in smelter-contaminated soils. Basta, NT; Casteel, SW; Dayton, EA; Foster, JN; Rodriguez, RR, 2007) | 0.34 |
| " Significant dose-response relationship was observed between control and treatment groups after 1, 4, 24, 32, 48, 56, 88, 96 and 104 weeks." | ( Urinary arsenic and porphyrin profile in C57BL/6J mice chronically exposed to monomethylarsonous acid (MMAIII) for two years. Krishnamohan, M; Lam, PK; Moore, MR; Ng, JC; Qi, L, 2007) | 0.34 |
| " The present study demonstrated a dose-response relationship between blood lead and hearing thresholds, after adjusting other potential confounders in multiple regressions." | ( A case-control study on the relationship of hearing function and blood concentrations of lead, manganese, arsenic, and selenium. Chen, CJ; Chiu, YW; Chuang, HY; Ho, CK; Kuo, CH; Wu, TN, 2007) | 0.34 |
| " The results show that sodium arsenite, arsenic trioxide, monomethylarsonic acid and dimethylarsinic acid are mutagenic, showing a clear dose-response pattern." | ( Gene-mutation induction by arsenic compounds in the mouse lymphoma assay. Creus, A; Marcos, R; Soriano, C, 2007) | 0.34 |
| " Approximately half of the examined children exhibited dermatological symptoms with relatively obscured dose-response relationship; an observation suggesting that the children were no more susceptible to the dermatological effects of arsenic than the adults living in the same communities." | ( Dermatological and nutritional/growth effects among children living in arsenic-contaminated communities in rural Bangladesh. Bae, MJ; Bokul, AT; Inaoka, T; Kadono, T; Matsui, T; Miyazaki, K; Ohtsuka, R; Ono, T; Watanabe, C, 2007) | 0.34 |
| " Occupational sunlight exposure was associated with cortical and posterior subcapsular opacities in a dose-response relationship." | ( Dose-response relationship between ingested arsenic and cataracts among residents in Southwestern Taiwan. Chen, CJ; Chiou, HY; Hsueh, YM; Lee, JS; Lin, SM; See, LC; Tu, MC; Yang, ML, 2007) | 0.34 |
| " Our study highlights the need for (i) adequate epidemiological studies involving multiple exposure categories, ideally resulting in an accurate dose-response relationship for arsenic uptake and the non-malignant high incidence conditions diabetes mellitus and ischemic heart disease for individuals with the socioeconomic and nutritional status of the Bangladeshi populations, and (ii) refined estimates of the diarrhoel disease burden arising from usage of surface waters." | ( Critical pathway analysis to determine key uncertainties in net impacts on disease burden in Bangladesh of arsenic mitigation involving the substitution of arsenic bearing for groundwater drinking water supplies. Adamson, GC; Polya, DA, 2007) | 0.34 |
| "The oxidation of As(III) with potassium permanganate was studied under conditions including pH, initial As(III) concentration and dosage of Mn(VII)." | ( Oxidation of As(III) by potassium permanganate. Fan, M; Huang, CP; Li, N; Saha, B; Van Leeuwen, J; Yang, H, 2007) | 0.34 |
| " As the adsorbent dosage and initial arsenic concentration were fixed, both the As(V) and As(III) removals decrease with increasing initial solution pH." | ( Removal of As(V) and As(III) by reclaimed iron-oxide coated sands. Chen, ST; Hsu, JC; Liao, CH; Lin, CJ, 2008) | 0.35 |
| "5-fold risk of carotid atherosclerosis after adjustment for age and gender, revealing a significant dose-response relationship between number of risk genotypes of these genes and risk of carotid atherosclerosis." | ( Risk of carotid atherosclerosis associated with genetic polymorphisms of apolipoprotein E and inflammatory genes among arsenic exposed residents in Taiwan. Chen, CJ; Chiou, HY; Chou, YL; Hsieh, FI; Hsieh, YC; Lien, LM, 2008) | 0.35 |
| "Regulatory focus on quantifying risk of disease or death from exposure to hazardous substances via monotonic dose-response models has downplayed or even rejected potential benefits to human health from exposures to low (sub-threshold) doses, and thus represented by either U-shaped or J-shaped models." | ( Hormesis and precaution: the twain shall meet. MacDonald, TR; Ricci, PF, 2007) | 0.34 |
| " A dose-response relationship was shown between plasma folate levels or methylation indices of arsenic species and UC risk in the respective quartile strata." | ( Plasma folate level, urinary arsenic methylation profiles, and urothelial carcinoma susceptibility. Chen, CJ; Chung, CJ; Hsueh, YM; Huang, YK; Pu, YS; Shiue, HS; Yang, MH, 2008) | 0.35 |
| " Our results show a positive relationship between arsenic exposure and age/gender- and cancer-specific cumulative incidence ratio using Weibull dose-response model." | ( Arsenic cancer risk posed to human health from tilapia consumption in Taiwan. Chen, CJ; Chen, CL; Chen, SC; Hsu, LI; Liao, CM; Lin, TL; Shen, HH, 2008) | 0.35 |
| " We linked the Weibull dose-response function and a physiologically based pharmacokinetic (PBPK) model to estimate safe drinking water arsenic concentrations and to perform the risk characterization." | ( A Weibull-PBPK model for assessing risk of arsenic-induced skin lesions in children. Chen, SC; Liao, CM; Lin, TL, 2008) | 0.35 |
| " Nestling finches were orally dosed for 20 d from hatching to fledging with 4, 8, 12, 24, 36, or 72 microg/g bw/d of monomethylarsonic acid (MMA(V), which corresponds to MSMA at physiological pH)." | ( Tissue uptake, mortality, and sublethal effects of monomethylarsonic acid (MMA(V)) in nestling zebra finches (Taeniopygia guttata). Albert, C; Cullen, WR; Elliott, JE; Lai, VW; Morrissey, CA; Williams, TD, 2008) | 0.35 |
| " Many of these human studies provide clear evidence of a dose-response relationship." | ( Inorganic arsenic and human prostate cancer. Benbrahim-Tallaa, L; Waalkes, MP, 2008) | 0.35 |
| "Capillary electrophoresis coupled to inductively coupled plasma mass spectrometry was used in a speciation study on disodium monomethylarsonate (DS-MMA(V)) and its metabolites in horses, to which the drug was administered by intramuscular injection on five consecutive days at a single arsenic dosage of 270 mg day(-1)." | ( Intake and excretion of disodium monomethylarsonate in horses: a speciation study. Assis, RA; Kuchler, IL; Miekeley, N; Tozzi, MB, 2008) | 0.35 |
| " Further studies using ATO and AA with TMZ with this dosing schedule in advanced melanoma are not warranted." | ( Phase II trial of arsenic trioxide and ascorbic acid with temozolomide in patients with metastatic melanoma with or without central nervous system metastases. Bael, TE; Gollob, JA; Peterson, BL, 2008) | 0.35 |
| " The effect of operating factors such as pH, contact time, initial As(V) concentration and adsorbent dosage was investigated and the optimum operating conditions were established." | ( An effective adsorbent developed from municipal solid waste and coal co-combustion ash for As(V) removal from aqueous solution. Fan, Y; Feng, Y; Zhang, FS, 2008) | 0.35 |
| " The present study described the removal of As(V) on bone char in batch studies conducted as a function of pH, dosage of adsorbent, and contact time." | ( Study of arsenic(V) adsorption on bone char from aqueous solution. Chai, LY; Chen, YN; Shu, YD, 2008) | 0.35 |
| " No mice died in any dosage group." | ( Arsenic trioxide impairs spermatogenesis via reducing gene expression levels in testosterone synthesis pathway. Chiou, TJ; Chu, ST; Huang, YC; Liao, CJ; Tzeng, WF, 2008) | 0.35 |
| " The higher total arsenic concentration, monomethylarsonic acid percentage (MMA%) and lower dimethylarsinic acid percentage (DMA%), possessed greater gene variant numbers, had a higher UC risk and revealed significant dose-response relationships." | ( Polymorphisms in cell cycle regulatory genes, urinary arsenic profile and urothelial carcinoma. Chen, YT; Chung, CJ; Hsueh, YM; Huang, CJ; Huang, YK; Pu, YS; Su, CT, 2008) | 0.35 |
| " This multi-institution phase II study investigated a novel dosing schedule of As(2)O(3) and AA in patients with relapsed or refractory lymphoid malignancies." | ( Phase II study of arsenic trioxide and ascorbic acid for relapsed or refractory lymphoid malignancies: a Wisconsin Oncology Network study. Ahuja, HG; Bailey, HH; Chang, JE; Kahl, BS; Kim, K; Kolesar, JM; Rodriguez, GA; Sanchez, FA; Voorhees, PM; Werndli, J, 2009) | 0.35 |
| " With these drug therapies has come a more targeted approach to treatment enabling not only improved antimyeloma efficacy but also the use of decreased dosing enhancing the safety and tolerability of these regimens." | ( New drugs in multiple myeloma. Berenson, JR; Yellin, O, 2008) | 0.35 |
| " The results of this study indicate a significant dose-response relationship with the highest concentration of arsenic producing the greatest amount of TPO inhibition." | ( The minimal arsenic concentration required to inhibit the activity of thyroid peroxidase activity in vitro. Jansen, KP; Palazzolo, DL, 2008) | 0.35 |
| ", inadequate statistical power, exposure misclassification), or to differences in the dose-response relationship at high versus low exposures." | ( Low-level arsenic exposure in drinking water and bladder cancer: a review and meta-analysis. Alexander, DD; Barraj, LM; Kelsh, MA; Mink, PJ; Tsuji, JS, 2008) | 0.35 |
| "It has been well documented that long-term exposure to inorganic arsenic induces cancers and vascular diseases in a dose-response relationship." | ( Arsenic trioxide mutational spectrum analysis in the mouse lymphoma assay. Creus, A; Marcos, R; Soriano, C, 2008) | 0.35 |
| " Total As and As speciation were analyzed to evaluate dose-response relationship between As accumulation and NRRTs and to observe the role of As metabolism in earthworms on a subcellular level toxicity." | ( Lysosomal membrane response of earthworm, Eisenia fetida, to arsenic contamination in soils. Kim, KW; Lee, BT, 2009) | 0.35 |
| " pallida three were positive, although no clear dose-response were observed for both plants." | ( Evaluation of the genotoxicity of treated urban sludge in the Tradescantia micronucleus assay. Matta, ME; Mielli, AC; Nersesyan, A; Saldiva, PH; Umbuzeiro, GA, 2009) | 0.35 |
| " New studies address the dose-response relationship between drinking-water arsenic concentrations and skin lesions, and new findings have emerged concerning arsenic and cardiovascular disease." | ( Health effects of arsenic and chromium in drinking water: recent human findings. Smith, AH; Steinmaus, CM, 2009) | 0.35 |
| " Arsenic exposure of mice after weaning shows a clear dose-response in the extent of disease exacerbation." | ( Arsenic and cardiovascular disease. Barchowsky, A; Chen, Y; Srivastava, S; States, JC, 2009) | 0.35 |
| " Phytotoxicity parameters were estimated from a dose-response experiment using the aboveground dry matter growth endpoint and were correlated with an assortment of relevant soil property measurements, with the ultimate goal of developing statistical prediction models for soil-specific adjustments to ecological risk assessments." | ( Application of ridge regression to quantify marginal effects of collinear soil properties on phytotoxicity of arsenic, cadmium, lead, and zinc. Anderson, RH; Basta, NT, 2009) | 0.35 |
| " We present an integrated approach by linking the Weibull dose-response function and a physiologically based pharmacokinetic (PBPK) model to estimate reference arsenic guideline." | ( Risk assessment of arsenic-induced internal cancer at long-term low dose exposure. Chen, CJ; Chen, CL; Chen, SC; Hsu, LI; Liao, CM; Lin, TL; Shen, HH, 2009) | 0.35 |
| " Methylation capacity might reduce with increasing dosage of arsenic exposure." | ( A review on environmental factors regulating arsenic methylation in humans. Tseng, CH, 2009) | 0.35 |
| " In this paper, we consider lung cancer dose-response relationships for inhalation and ingestion of arsenic by focusing on two key studies, a cohort mortality study in the United States involving Tacoma smelter workers inhaling arsenic, and a lung cancer case-control study involving ingestion of arsenic in drinking water in northern Chile." | ( Increased lung cancer risks are similar whether arsenic is ingested or inhaled. Ercumen, A; Smith, AH; Steinmaus, CM; Yuan, Y, 2009) | 0.35 |
| " The optimum As(III) removal was achieved at a permanganate dosage of 18." | ( Removal of arsenic from water: effect of calcium ions on As(III) removal in the KMnO(4)-Fe(II) process. Dong, H; Guan, X; Jiang, L; Ma, J, 2009) | 0.35 |
| " We used a physiologically based pharmacokinetic model with a dose-response relationship based on an empirical three-parameter Hill equation model to simulate the exposure time-dependent arsenic dose profiles in human tissues and to estimate quantitatively the inhalation exposure risks." | ( Assessing airborne PM-bound arsenic exposure risk in semiconductor manufacturing facilities. Chio, CP; Chou, WC; Liao, CM, 2009) | 0.35 |
| " The in vitro results also showed a dose-response relationship between arsenite concentrations and hTERT expression and reached the peak at 1 microM." | ( Elevated human telomerase reverse transcriptase gene expression in blood cells associated with chronic arsenic exposure in Inner Mongolia, China. Mo, J; Mumford, JL; Ning, Z; Wade, TJ; Xia, Y, 2009) | 0.35 |
| " We evaluated the cancer risks caused by exposure to arsenic in two communities through combining geostatistical simulation with demographic data and dose-response models in a framework." | ( Health risks from arsenic-contaminated soil in Flin Flon-Creighton, Canada: integrating geostatistical simulation and dose-response model. Huang, GH; Zeng, GM; Zhang, H, ) | 0.13 |
| " The proposed valve daily activity model was linked with response time-specific Hill dose-response functions to predict valve opening/closing behavior in response to arsenic." | ( Valve movement response of the freshwater clam Corbicula fluminea following exposure to waterborne arsenic. Chang, FJ; Jau, SF; Jou, LJ; Liao, CM; Liao, VH; Lin, CM; Liu, CW, 2009) | 0.35 |
| " Our results showed the increased level of As concentration in cerebellar tissue of the exposed mice in a dose-response manner, longer escape latency in the experimental group than controls and the down-regulated expression of Ca(2+)/calmodulin dependent protein kinase IV (Camk4), a very important regulator in the LTD pathway." | ( Arsenic down-regulates the expression of Camk4, an important gene related to cerebellar LTD in mice. Hong, Y; Li, S; Liu, P; Piao, F; Wang, Y; Zhao, Y, ) | 0.13 |
| " Western Blot and densitometric analyses demonstrated a strong dose-response relationship with regard to p53 and RARE expression within the dose-range of 0-8 microg/ml." | ( Modulation of p53, c-fos, RARE, cyclin A, and cyclin D1 expression in human leukemia (HL-60) cells exposed to arsenic trioxide. Tchounwou, PB; Yedjou, CG, 2009) | 0.35 |
| " We linked a physiologically based pharmacokinetic (PBPK) and a pharmacodynamic (PD) model to account for the exposure and dose-response profiles of As in human." | ( A human PBPK/PD model to assess arsenic exposure risk through farmed tilapia consumption. Liao, CM; Ling, MP, 2009) | 0.35 |
| " The patient numbers were generally small, treatment regimens differed both regarding the dosage of ATO and combinations with other drugs." | ( The efficacy of arsenic trioxide for the treatment of relapsed and refractory multiple myeloma: a systematic review. Illmer, T; Röllig, C, 2009) | 0.35 |
| " But the dosage and administration ways are undetermined yet." | ( Effects of arsenic trioxide under different administration ways on T-cell lymphoma xenografts in nude mice: in vivo and in vitro experiments. Bu, Q; Cai, QQ; Gao, Y; Huang, HQ; Li, S; Liao, H; Zhou, Y, 2009) | 0.35 |
| "Shortening the administration course and increasing the daily dosage of As(2)O(3) can be considered as a reasonable model for treating advanced/refractory lymphomas." | ( Effects of arsenic trioxide under different administration ways on T-cell lymphoma xenografts in nude mice: in vivo and in vitro experiments. Bu, Q; Cai, QQ; Gao, Y; Huang, HQ; Li, S; Liao, H; Zhou, Y, 2009) | 0.35 |
| " Data from acute in vivo exposures are of limited value for evaluating the dose-response for gene expression, because of the transient, variable, and uncertain nature of tissue exposure in these studies." | ( Analysis of genomic dose-response information on arsenic to inform key events in a mode of action for carcinogenicity. Clewell, HJ; Gentry, PR; McDonald, TB; Shipp, AM; Sullivan, DE; Yager, JW, 2010) | 0.36 |
| " Dose-response relationships were shown between UCd and the prevalence of increased levels of biomarkers in urine of renal tubular dysfunction such as urinary beta-2-microglobulin or N-acetyl-beta-d-glucosaminidase - NAG or urinary albumin, a biomarker of glomerular kidney dysfunction." | ( Prevalence of kidney dysfunction in humans - relationship to cadmium dose, metallothionein, immunological and metabolic factors. Chen, L; Hong, F; Jin, T; Lei, L; Lu, J; Nordberg, GF; Nordberg, M; Wu, X, 2009) | 0.35 |
| " Flocs recycling can obviously promoted the As(V) removal by enhanced coagulation and reduce the dosage of coagulant with recycling point set at rapid mixed site and recycling ratio at 50%." | ( [Pilot study on pentavalent arsenic removal by coagulation and the strengthening effect of flocs recycling]. Chen, BB; Gao, NY; Xia, SJ; Yao, JJ, 2009) | 0.35 |
| " After a 15-year follow-up, baseline monomethylarsonic acid percentage (MMA%) and change in MMA% exhibited a significant dose-response relationship with cancer risk." | ( Polymorphisms in arsenic metabolism genes, urinary arsenic methylation profile and cancer. Bai, CH; Chen, CJ; Chung, CJ; Hsueh, YM; Huang, YK; Huang, YL; Yang, MH, 2009) | 0.35 |
| " Total arsenic level was associated significantly with CKD in a dose-response relationship, especially in participants with a total arsenic level greater than 20." | ( Urinary arsenic species and CKD in a Taiwanese population: a case-control study. Chen, JB; Chiang, SS; Chung, CJ; Hsueh, YM; Shiue, HS; Su, CT; Tai, CW; Yang, MH, 2009) | 0.35 |
| "Our previous study combining two arseniasis-endemic areas in Taiwan confirmed a dose-response association of lung cancer and arsenic exposure." | ( Ingested arsenic, characteristics of well water consumption and risk of different histological types of lung cancer in northeastern Taiwan. Chen, CJ; Chen, CL; Chiou, HY; Hsu, LI; Hsueh, YM; Wu, MM, 2010) | 0.36 |
| " Since increasing the dosage of chemotherapeutic agents could also elevate toxicity, a solution to how one could achieve maximum therapeutic effect with the minimum dosage possible is imminent." | ( Synergistic mitosis-arresting effects of arsenic trioxide and paclitaxel on human malignant lymphocytes. Chen, GQ; Duan, XF; Wang, XD; Wu, YL; Xu, HZ; Yan, H; Zhao, M; Zhuang, HY, 2010) | 0.36 |
| " We observed clear dose-response relationships for each of these causes." | ( Arsenic in drinking water and adult mortality: a population-based cohort study in rural Bangladesh. Ekström, EC; Persson, LA; Rahman, M; Sohel, N; Streatfield, PK; Vahter, M; Yunus, M, 2009) | 0.35 |
| "Renal impairment did increase the systemic exposure to arsenic and its methylated metabolites following standard daily dosing of arsenic trioxide." | ( A pharmacokinetic and safety study of intravenous arsenic trioxide in adult cancer patients with renal impairment. D'Andrea, DM; Darwish, M; Porter, JM; Remick, SC; Sweeney, CJ; Takimoto, C; Tracewell, WG; Wood, L, 2010) | 0.36 |
| " Published age- and gender-specific skin lesions data in West Bengal were reanalyzed and incorporated into a Weibull dose-response model to predict children skin lesion prevalence." | ( Assessing the arsenic-contaminated rice (Oryza sativa) associated children skin lesions. Chen, WY; Hsieh, NH; Liao, CM; Lin, TL, 2010) | 0.36 |
| " There was a clear dose-response seen in the number of DEGs for all four compounds." | ( Genome-wide analysis of BEAS-2B cells exposed to trivalent arsenicals and dimethylthioarsinic acid. Bailey, K; Chilakapati, J; Creed, J; Fricke, M; Kitchin, K; Ren, H; Wallace, K; Ward, W, 2010) | 0.36 |
| " The results indicated that repeated arsenic preexposure decreased susceptibility of rat kidney to acute AP-mediated oxidative stress; on the contrary, its coexposure rendered the rat kidney more vulnerable to oxidative stress induced by the repeated dosing of AP." | ( Repeated preexposure or coexposure to arsenic differentially alters acetaminophen-induced oxidative stress in rat kidney. Manimaran, A; Sankar, P; Sarkar, SN, 2011) | 0.37 |
| " Furthermore, while there are vast amounts of toxicological data on iAs, relatively little of it has been collected using experimental designs that efficiently support development of biologically based dose-response (BBDR) models and subsequently risk assessment." | ( Arsenic-induced carcinogenesis--oxidative stress as a possible mode of action and future research needs for more biologically based risk assessment. Conolly, R; Kitchin, KT, 2010) | 0.36 |
| " A previous study conducted in northeastern Taiwan, where residents were exposed to relatively lower concentrations, reported increased risk of urinary cancer in a dose-response way." | ( Arsenic in drinking water and risk of urinary tract cancer: a follow-up study from northeastern Taiwan. Chen, CJ; Chen, CL; Chiou, HY; Hsu, LI; Hsueh, YM; Wang, YH; Wu, MM, 2010) | 0.36 |
| "Arsenic in drinking water has been linked with the risk of urinary bladder cancer, but the dose-response relationships for arsenic exposures below 100 microg/L remain equivocal." | ( Lifetime exposure to arsenic in drinking water and bladder cancer: a population-based case-control study in Michigan, USA. AvRuskin, GA; Franzblau, A; Goovaerts, P; Jacquez, GM; Meliker, JR; Nriagu, JO; Schottenfeld, D; Slotnick, MJ; Wilson, ML, 2010) | 0.36 |
| " f BY-3) were investigated as a function of pH, contact time, initial arsenic concentration, biomass dosage and temperature in this study." | ( Biosorption of inorganic and organic arsenic from aqueous solution by Acidithiobacillus ferrooxidans BY-3. Leng, F; Li, H; Nan, W; Yan, L; Yin, H; Zhang, S, 2010) | 0.36 |
| "Complete remission was observed in 17 (85%) patients with the median duration of 28 days (18-38) and cumulative dosage of median 280 mg (180-350)." | ( The expression of p38, ERK1 and Bax proteins has increased during the treatment of newly diagnosed acute promyelocytic leukemia with arsenic trioxide. Alimoghaddam, K; Ghaffari, SH; Ghahremani, MH; Ghavamzadeh, A; Hosseini, R; Mandegary, A; Rostami, S, 2010) | 0.36 |
| "5 mm thickness were made from a polyester resin-salt mixture and dosed with equal arsenic and selenium concentrations ranging from 0 to 30 microg g(-1)." | ( Simultaneous assessment of arsenic and selenium in human nail phantoms using a portable x-ray tube and a detector. Fleming, DE; Gherase, MR; Roy, CW, 2010) | 0.36 |
| " Interpreting the health implications of As concentrations in biological samples is limited by the small number of studies that provide information on the correlation and dose-response relationship between biomonitoring test results and adverse health effects." | ( Biomonitoring for environmental exposures to arsenic. Metcalf, S; Mistry, K; Orloff, K, 2009) | 0.35 |
| " While there were instances of significant alterations at individual time points and within cell line-to-cell line comparisons there was no evidence of a dose-response relationship or correlations to the phenotypic properties of the cell lines." | ( Beclin-1 expression in normal bladder and in Cd2+ and As3+ exposed and transformed human urothelial cells (UROtsa). Dunlevy, JR; Garrett, SH; Larson, JL; Sens, DA; Sens, MA; Somji, S; Zhou, XD, 2010) | 0.36 |
| " More studies are needed to investigate the long-term effects and dose-response relationship of arsenic in the region and similar areas." | ( Arsenic exposure, dermatological lesions, hypertension, and chromosomal abnormalities among people in a rural community of northwest Iran. Azarfam, P; Dastgiri, S; Fizi, MA; Mosaferi, M; Olfati, N; Pouladi, N; Zolali, S, 2010) | 0.36 |
| " This synergistic effects is related to the dosage and treatment time." | ( [Apoptosis of NB4 cells induced by Tanshinone II A combined with arsenic trioxide]. Meng, WT; Yang, YM; Zhang, G; Zhou, J, 2010) | 0.36 |
| "Quantitation of iAs and its methylated metabolites in biological samples provides dosimetric information needed to understand dose-response relations." | ( Analysis of arsenical metabolites in biological samples. Drobna, Z; Hernandez-Zavala, A; Styblo, M; Thomas, DJ, 2009) | 0.35 |
| "This prospective cohort study found a dose-response relationship between As exposure and clinical symptoms of respiratory diseases in Bangladesh." | ( A prospective study of respiratory symptoms associated with chronic arsenic exposure in Bangladesh: findings from the Health Effects of Arsenic Longitudinal Study (HEALS). Ahmed, A; Ahsan, H; Argos, M; Balac, O; Brandt-Rauf, PW; Chen, Y; Graziano, JH; Haque, SE; Hassan, R; Islam, T; Parvez, F; Slavkovich, V; Yunus, M, 2010) | 0.36 |
| " By coupling the age-specific physiologically based pharmacokinetic (PBPK) model and a Weibull-based dose-response function, a more accurate estimate of urinary arsenic metabolites could be achieved to better characterize potential cancer risks." | ( Assessing the cancer risk associated with arsenic-contaminated seafood. Chen, BC; Chen, WY; Chou, WC; Liao, CM, 2010) | 0.36 |
| " BE values corresponding to the Reference Dose (RfD) or risk-specific doses for cancer endpoints from these agencies were derived based on kinetic data (urinary excretion) from controlled dosing studies in humans." | ( Biomonitoring equivalents for inorganic arsenic. Aylward, LL; Gagné, M; Hays, SM; Krishnan, K; Nong, A, 2010) | 0.36 |
| " The study also demonstrated a dose-response effect of arsenic exposure and lung function decrement." | ( Lung function decrement with arsenic exposure to drinking groundwater along River Indus: a comparative cross-sectional study. Ali, A; Fatmi, Z; Irfan, M; Kayama, F; Kazi, A; Nafees, AA, 2011) | 0.37 |
| " However, estimated cumulative daily intakes from tested homeopathic products were in all cases lower than permitted daily exposures for all dosage forms." | ( Preliminary investigation of metal and metalloid contamination of homeopathic products marketed in Croatia. Bosnir, J; Dragun, Z; Puntarić, D; Tomić, S; Tumir, H; Vedrina-Dragojević, I, 2010) | 0.36 |
| "Flow cytometry data showed a strong dose-response relationship between ATO exposure and Annexin-V positive HL-60 cells." | ( Basic mechanisms of arsenic trioxide (ATO)-induced apoptosis in human leukemia (HL-60) cells. Jenkins, J; McMurray, R; Tchounwou, P; Yedjou, C, 2010) | 0.36 |
| "Twenty-four experimental canines were equally divided into 4 groups, the three tested groups were deployed by stents with different dosage of As2O3 (1." | ( [Effects of control-releasing arsenic trioxide-eluting stent on intimal smooth muscle cells and type III collagen in canine coronary artery post-stent model]. Sun, BG; Wen, QZ; Zhao, JL, 2010) | 0.36 |
| " During the post dosing clearance period, arsenic body burdens declined in As3mt knockout mice to ~35% and in wild-type mice to ~10% of steady-state levels." | ( Arsenic (+3 oxidation state) methyltransferase genotype affects steady-state distribution and clearance of arsenic in arsenate-treated mice. Edwards, BC; Herbin-Davis, KM; Hughes, MF; Saunders, J; Styblo, M; Thomas, DJ, 2010) | 0.36 |
| " We demonstrated that when dose-response curves were fitted with the same method, similar evaluated results for drug combinations would be derived with different models." | ( [Three different drug interaction mathematical models used to evaluate the cytotoxicity of SAHA and arsenic trioxide in combination]. Liu, ZJ; Lu, N; Wang, N; Yan, Z, 2010) | 0.36 |
| " The dose-response relationships in PND1 tissues were curvilinear, but in PND21 liver and kidney tissues, arsenic levels in control animals were significantly higher than levels in exposed animals." | ( Tissue-specific and dose-related accumulation of arsenic in mouse offspring following maternal consumption of arsenic-contaminated water. Currie, D; Markowski, VP; Reeve, EA; Thompson, D; Wise, JP, 2011) | 0.37 |
| "For cadmium, the lack of statistical significance of most results, potential confounding and the absence of clear dose-response relations suggest that an association with RCC is unlikely to be causal." | ( Occupational exposure to arsenic, cadmium, chromium, lead and nickel, and renal cell carcinoma: a case-control study from Central and Eastern Europe. Bencko, V; Boffetta, P; Brennan, P; Chow, WH; Ferro, G; Fontana, L; Foretova, L; Janout, V; Jinga, V; Karami, S; Kollarova, H; Matveev, V; Moore, LE; Rothman, N; Stewart, P; Szeszenia-Dabrowska, N; van Bemmel, D; Zaridze, D, 2011) | 0.37 |
| "98 mg g(-1) at 25°C at a siderite dosage of 2 g L(-1)." | ( Removal of arsenite from water by synthetic siderite: behaviors and mechanisms. Guo, H; Li, Y; Ren, Y; Wei, C; Zhao, K, 2011) | 0.37 |
| " In the chronic study, two of four rats suddenly died by the repeated dosing of ATO, whereas no deaths were observed in combination with LA." | ( Protective effect of α-lipoic acid against arsenic trioxide-induced acute cardiac toxicity in rats. Ando, H; Fujimura, A; Hosohata, K; Koshimizu, TA; Kumazaki, M; Oshima, Y; Sasaki, A; Ushijima, K, 2011) | 0.37 |
| " Moreover, on the basis of the results obtained in the present work, it is concluded that the present techniques are suitable for the routine determination of toxic metals concentration in various pharmaceutical dosage forms." | ( Toxic metal contamination in Artemisia annua L. herbal preparations from different commercial sources in China. Tan, Y; Wang, Y; Wu, J; Xu, R, 2011) | 0.37 |
| " However, higher UAs was modestly associated with higher scores on the Oppositional, Cognitive Problems and ADHD sub-scales of the teacher ratings; a dose-response relationship was not established between UAs quartiles and behavior." | ( Association between arsenic exposure and behavior among first-graders from Torreón, Mexico. Cebrian, ME; Kordas, K; Lopez, P; Ronquillo, D; Rosado, JL; Roy, A; Stoltzfus, RJ; Vargas, GG, 2011) | 0.37 |
| "Urinary total arsenic was significantly associated with renal cell carcinoma risk in a dose-response relationship after multivariate adjustment." | ( Effect of urinary total arsenic level and estimated glomerular filtration rate on the risk of renal cell carcinoma in a low arsenic exposure area. Chu, JS; Chung, CJ; Hsueh, YM; Huang, CY; Pu, YS; Wu, CC; Yang, HY, 2011) | 0.37 |
| " There was a dose-response relation between exposure to arsenic in well water assessed at baseline and mortality from ischaemic heart disease and other heart disease; the hazard ratios in increasing quarters of arsenic concentration in well water (0." | ( Arsenic exposure from drinking water and mortality from cardiovascular disease in Bangladesh: prospective cohort study. Ahmed, A; Ahsan, H; Argos, M; Chen, Y; Graziano, JH; Hasan, R; Islam, T; Kalra, T; Levy, D; Liu, M; Parvez, F; Rakibuz-Zaman, M; Sarwar, G; Slavkovich, V; van Geen, A, 2011) | 0.37 |
| " Above ground wheat biomass from a 21-day early growth bioassay was adopted as the response variable and the dose-response relationships were modelled using the three-parameter sigmoid equation." | ( Modelling arsenic toxicity in wheat: simultaneous application of diffusive gradients in thin films to arsenic and phosphorus in soil. Condron, LM; McLaren, RG; Mojsilovic, O, 2011) | 0.37 |
| " The result showed that a significant dose-response trend (P=0." | ( Significantly increased risk of carotid atherosclerosis with arsenic exposure and polymorphisms in arsenic metabolism genes. Chen, CJ; Chiou, HY; Chung, WT; Hsieh, FI; Hsieh, PF; Hsieh, YC; Lien, LM; Tseng, HP; Wu, MM, 2011) | 0.37 |
| " However, serum hepatic enzyme activity as recognized on liver function tests (LFTs) showing a dose-response relationship with arsenic exposure has not yet been clearly documented." | ( Dose-response relationship between arsenic exposure and the serum enzymes for liver function tests in the individuals exposed to arsenic: a cross sectional study in Bangladesh. Akhand, AA; Ali, N; Fajol, A; Haque, A; Himeno, S; Hossain, E; Hossain, K; Hossain, M; Islam, K; Karim, R; Mandal, A; Miyataka, H; Rahman, M; Salam, KA; Saud, ZA; Sultana, P, 2011) | 0.37 |
| " With internal exposure markers (arsenic in hair and nails), the ALP, AST and ALT activity profiles assumed a similar shape of dose-response relationship, with very few differences seen in the higher groups compared to the lowest group, most likely due to the temporalities of exposure metrics." | ( Dose-response relationship between arsenic exposure and the serum enzymes for liver function tests in the individuals exposed to arsenic: a cross sectional study in Bangladesh. Akhand, AA; Ali, N; Fajol, A; Haque, A; Himeno, S; Hossain, E; Hossain, K; Hossain, M; Islam, K; Karim, R; Mandal, A; Miyataka, H; Rahman, M; Salam, KA; Saud, ZA; Sultana, P, 2011) | 0.37 |
| " Dose-response relationship between arsenic exposure and risk of urothelial carcinoma (UC) is consistently observed." | ( Genetic polymorphisms in glutathione S-transferase (GST) superfamily and risk of arsenic-induced urothelial carcinoma in residents of southwestern Taiwan. Chen, CJ; Chen, WP; Chen, YH; Chiou, HY; Hsu, LI; Hsueh, YM; Liao, YT; Lo, WC; Wang, YH; Wu, MM; Yang, TY, 2011) | 0.37 |
| " The concentration of total arsenic and As(III) + DMA (arsenite + dimethylarsenic acid) increased with dosing of realgar." | ( [Tissue distribution of arsenic of liushen pills and realgar]. Fan, MW; Liang, QL; Luo, GA; Shen, LZ; Wang, YM; Wu, Q; Xie, YY; Zhang, QL, 2011) | 0.37 |
| " Many studies have indicated a dose-response relationship between accumulative arsenic exposure and the prevalence of diabetes mellitus (DM) in arseniasis-endemic areas in Taiwan and Bangladesh, where arsenic exposure occurs through drinking water." | ( Arsenic and diabetes: current perspectives. Chen, YW; Huang, CF; Liu, SH; Tsai, KS; Yang, CY; Yang, RS, 2011) | 0.37 |
| " Understanding the in vivo production of MAsIII and DMAsIII in mice exposed to iAs could aid in developing a biologically based dose-response model for iAs." | ( Dose-dependent urinary phenotype of inorganic arsenic methylation in mice with a focus on trivalent methylated metabolites. Albores, A; Del Razo, LM; García-Montalvo, EA; Sánchez-Peña, LC; Valenzuela, OL, 2011) | 0.37 |
| " A high content of Al(30) nanoclusters in PACl improves the removal efficiency over broader dosage and pH range." | ( Polyaluminum chloride with high Al30 content as removal agent for arsenic-contaminated well water. Casentini, B; Furrer, G; Masion, A; Mertens, J; Pöthig, R; Wehrli, B, 2012) | 0.38 |
| " A significant dose-response relationship was found for arsenic (as well as smoking) in relation to dyspnoea." | ( Arsenic exposure from drinking water and dyspnoea risk in Araihazar, Bangladesh: a population-based study. Ahmed, A; Ahsan, H; Chen, Y; Hasan, R; Parvez, F; Pesola, GR, 2012) | 0.38 |
| " A dose-response assessment including six studies with available data showed an increasing trend in the odds of hypertension with increasing arsenic exposure." | ( Arsenic exposure and hypertension: a systematic review. Abhyankar, LN; Guallar, E; Jones, MR; Navas-Acien, A, 2012) | 0.38 |
| " Additional evidence is needed to evaluate the dose-response relationship between environmental arsenic exposure and hypertension." | ( Arsenic exposure and hypertension: a systematic review. Abhyankar, LN; Guallar, E; Jones, MR; Navas-Acien, A, 2012) | 0.38 |
| " Thus, this study demonstrated a novel dose-response relationship between As exposure and plasma Big ET-1 levels indicating the possible involvement of plasma Big ET-1 levels in As-induced hypertension and skin lesions." | ( Elevated levels of plasma Big endothelin-1 and its relation to hypertension and skin lesions in individuals exposed to arsenic. Agarwal, S; Al Mamun, A; Aziz, A; Haque, A; Haris, PI; Himeno, S; Hossain, E; Hossain, K; Hossain, M; Hossain, MT; Hossain, S; Ikemura, N; Inoue, K; Islam, K; Karim, MR; Miyataka, H; Rahman, M; Sheikh, A; Yeasmin, F, 2012) | 0.38 |
| " We integrated valve daily rhythm dynamic patterns and water chemistry-based Hill dose-response model to build into a programmatic mechanism of inductance-based valvometry technique for providing a rapid and cost-effective dynamic detection system." | ( A real-time biomonitoring system to detect arsenic toxicity by valve movement in freshwater clam Corbicula fluminea. Chen, SH; Chen, WY; Jou, LJ; Liao, CM, 2012) | 0.38 |
| " The results revealed increased activities of SOD, GPx, GST, and MDA level in a dose-response manner while GR activity was decreased with increasing concentrations of fly ash." | ( Effect of fly ash on biochemical responses and DNA damage in earthworm, Dichogaster curgensis. Ghole, VS; Kodam, KM; Markad, VL, 2012) | 0.38 |
| "0, biosorbent dosage 5 g/L, contact time 240 min, and temperature 35 °C." | ( The characteristics of waste Saccharomyces cerevisiae biosorption of arsenic(III). Dai, Q; Wen, Y; Wu, Y; Zhou, J, 2012) | 0.38 |
| " As³⁺ induced a dose-dependent disassembly of cellular MTs and enhancement of the free tubulin pool, initiating an autoregulation of tubulin synthesis manifest as inhibition of steady-state mRNA levels of βI-tubulin in dosed lung cells and tissues." | ( Microtubules as a critical target for arsenic toxicity in lung cells in vitro and in vivo. Li, W; Toselli, P; Zhao, Y, 2012) | 0.38 |
| " HO-1 competitive inhibitor zinc protoporphyrin improved the cytotoxicity of arsenic in an inverted-U dose-response curve, indicating the biphasic hormetic effect of HO-1." | ( Arsenic modulates heme oxygenase-1, interleukin-6, and vascular endothelial growth factor expression in endothelial cells: roles of ROS, NF-κB, and MAPK pathways. Hu, LW; Kou, MC; Wang, L; Wang, YJ; Weng, CY; Wu, MJ, 2012) | 0.38 |
| " Based on the hypothesis that the relationship between exposure dosage and carcinogenic risk was linear, the calculation process of genetic carcinogens safety concentration was put forwarded, and the method using life-time exposed safety concentration to calculate short-term exposure safety concentration was set up." | ( [Safety concentration of genotoxic carcinogens in water pollution accident based on human health risk]. Fu, Q; Hung, MS; Luo, JH; Zheng, BH, 2012) | 0.38 |
| " Results showed that the maximum removal efficiency was reached with the calcination temperature of 350 degrees C for 90 minutes and an adhesive dosage of 10 mg x g(-1)." | ( [Modification of natural siderite and enhanced adsorption of arsenic]. Guo, HM; Li, Y; Ren, Y; Zhao, K, 2012) | 0.38 |
| " • We found that the response of roots was more distinct when the dosage was varied, whereas that of shoots was more distinct when the treatment time was varied." | ( Comparative transcriptome analysis of transporters, phytohormone and lipid metabolism pathways in response to arsenic stress in rice (Oryza sativa). Chen, L; Hu, SN; Li, JT; Liao, B; Luo, YF; Shu, WS; Xiao, S; Xie, LJ; Yu, LJ, 2012) | 0.38 |
| " A significant dose-response relationship was observed between arsenic exposure and LDH elevation, independent of urinary arsenic profiles (P<0." | ( Elevated lactate dehydrogenase activity and increased cardiovascular mortality in the arsenic-endemic areas of southwestern Taiwan. Chen, CJ; Chen, WJ; Hsu, LI; Huang, YL; Li, WF; Liao, YT; Sun, CW; Tsai, LY; Wang, SL, 2012) | 0.38 |
| " Level of urinary 8-OHdG was significantly associated with the OR of RCC in a dose-response relationship after multivariate adjustment." | ( Urinary total arsenic and 8-hydroxydeoxyguanosine are associated with renal cell carcinoma in an area without obvious arsenic exposure. Chu, JS; Chung, CJ; Hsueh, YM; Huang, CY; Pu, YS; Su, CT; Wu, CC; Yang, HY, 2012) | 0.38 |
| " For most levels of arsenic exposure, the risk estimates are higher with longer exposure; a dose-response pattern was also observed." | ( Association between type 2 diabetes and chronic arsenic exposure in drinking water: a cross sectional study in Bangladesh. Akter, S; Attia, J; D'Este, C; Hassan, SN; Islam, R; Khan, I; McEvoy, M; Milton, AH; Peel, R; Sultana, M, 2012) | 0.38 |
| " Our model predictions agree well with both data extracted from previous studies and our observed experimental data over a broad range of operating conditions (charge dosage rate) and solution chemistry (pH, co-occurring ions) without free model parameters." | ( Modeling As(III) oxidation and removal with iron electrocoagulation in groundwater. Addy, SE; Gadgil, AJ; Gao, N; Li, L; van Genuchten, CM; Yao, J, 2012) | 0.38 |
| " 5, 10, 20, 30 and 40 mg kg(-1) dry weights arsenic dosing was applied in pot soil and the results were compared with the control samples." | ( In vitro assessment on the impact of soil arsenic in the eight rice varieties of West Bengal, India. Banerjee, S; Bhattacharya, P; Majumdar, J; Samal, AC; Santra, SC, 2013) | 0.39 |
| " The predictions of the model are assessed against experimental data of arsenite-induced genotoxic damage to human hepatocytes; thereby capturing in silico the mode of the experimental dose-response curve." | ( A semi-mechanistic integrated toxicokinetic-toxicodynamic (TK/TD) model for arsenic(III) in hepatocytes. Androulakis, IP; Georgopoulos, PG; Kong, AN; Stamatelos, SK, 2013) | 0.39 |
| "5, at optimum conditions of contact time of 30 min, biomass dosage of 6 g/L, and temperature of 30 ± 2 °C." | ( Biosorption of arsenic (III) from aqueous solution by living cells of Bacillus cereus. Giri, AK; Mahapatra, SS; Mishra, PC; Patel, RK, 2013) | 0.39 |
| "We conducted a meta-analysis to explore dose-response relationships for bladder and lung cancers when people are chronically exposed to low doses of arsenic." | ( Low-dose risk assessment for arsenic: a meta-analysis approach. Begum, M; Horowitz, J; Hossain, MI, 2015) | 0.42 |
| " Therefore, we compared with the general population in Taiwan to calculate the standardized mortality ratio (SMR) in arseniasis-endemic area of Taiwan from 1996 to 2010 and evaluated the dose-response relationships between environmental arsenic exposure indices or urinary arsenic profiles and the mortality of cause-specific cancer." | ( Urinary arsenic profiles and the risks of cancer mortality: a population-based 20-year follow-up study in arseniasis-endemic areas in Taiwan. Chen, CJ; Chen, SY; Chung, CJ; Hsueh, YM; Huang, YK; Huang, YL; Wu, MM, 2013) | 0.39 |
| " To evaluate the dose-response relationship between arsenic in drinking water and mortality of liver cancer, we conducted a study in 138 villages in the southwest coast area of Taiwan." | ( Arsenic levels in drinking water and mortality of liver cancer in Taiwan. Chen, CY; Guo, HR; Lin, HJ; Sung, TI, 2013) | 0.39 |
| "The effects of cadmium (Cd) and arsenic (As), dosed alone or in combination have been poorly investigated in crustaceans." | ( The role of lipoic acid in the protection against of metallic pollutant effects in the shrimp Litopenaeus vannamei (Crustacea, Decapoda). Fattorini, D; Lobato, RO; Monserrat, JM; Nunes, SM; Regoli, F; Ventura-Lima, J; Wasielesky, W, 2013) | 0.39 |
| "We demonstrate that electrocoagulation (EC) using iron electrodes can reduce arsenic below 10 μg/L in synthetic Bangladesh groundwater and in real groundwater from Bangladesh and Cambodia, while investigating the effect of operating parameters that are often overlooked, such as charge dosage rate." | ( Arsenic removal from groundwater using iron electrocoagulation: effect of charge dosage rate. Amrose, S; Gadgil, A; Huang, J; Kostecki, R; Kowolik, K; Muller, M; Srinivasan, V, 2013) | 0.39 |
| "Although some studies mainly from Taiwan, Bangladesh and the United States, have suggested a consistent dose-response increase in the prevalence of hypertension with increasing arsenic exposure, the association between chronic environmental arsenic exposure and the risk of hypertension is still inconclusive." | ( Association of urinary monomethylated arsenic concentration and risk of hypertension: a cross-sectional study from arsenic contaminated areas in northwestern China. Li, B; Li, X; Sun, G; Wang, D; Xi, S; Zheng, Q, 2013) | 0.39 |
| "Forty-eight Wistar rats were divided into 4 groups randomly:control group,low dosage group, moderate dosage group and high dosage group." | ( [Effect of subchronic realgar exposure on Glu and Gln in infant rat brain]. Chang, B; Huo, TG; Jiang, H; Li, WK; Sun, GF; Yang, HL; Zhang, YH, 2012) | 0.38 |
| "The levels of MMA and DMA in brain increased as the dosage of realgar increased, while the second methylation index declined." | ( [Effect of subchronic realgar exposure on Glu and Gln in infant rat brain]. Chang, B; Huo, TG; Jiang, H; Li, WK; Sun, GF; Yang, HL; Zhang, YH, 2012) | 0.38 |
| "A significant dose-response trend was seen in the association of arsenic and inorganic intake with lung cancer risk in currently smoking men." | ( Dietary arsenic intake and subsequent risk of cancer: the Japan Public Health Center-based (JPHC) Prospective Study. Inoue, M; Iwasaki, M; Sasazuki, S; Sawada, N; Shimazu, T; Takachi, R; Tsugane, S; Yamaji, T, 2013) | 0.39 |
| " Moreover, significant dose-response joint effect of TNF-α -308 A/A or IL-8 -251 T/T genotypes and arsenic methylation indices were seen to affect UC risk." | ( Polymorphism of inflammatory genes and arsenic methylation capacity are associated with urothelial carcinoma. Chung, CJ; Hsueh, YM; Huang, CY; Huang, YK; Lai, LA; Lin, YC; Pu, YS; Shiue, HS; Su, CT; Wu, CC, 2013) | 0.39 |
| " The ratio of protein-bound arsenic to total arsenic decreased with increasing dosage of iAs(III) administered to the rats, suggesting a possible saturation of the binding capacity of the plasma proteins." | ( Arsenic speciation in the blood of arsenite-treated F344 rats. Arnold, LL; Chen, B; Cohen, SM; Le, XC; Lu, X; Shen, S, 2013) | 0.39 |
| " Among the circulating molecules tested in this study, HDL, Ox-LDL, and CRP showed dose-response relationships with arsenic exposure." | ( Increases in oxidized low-density lipoprotein and other inflammatory and adhesion molecules with a concomitant decrease in high-density lipoprotein in the individuals exposed to arsenic in Bangladesh. Agarwal, S; Aziz, A; Haris, PI; Himeno, S; Hossain, E; Hossain, K; Hossain, M; Hossain, MI; Hossain, S; Islam, K; Jenkins, RO; Karim, MR; Mamun, AA; Mandal, A; Miyataka, H; Nikkon, F; Rahman, M; Saud, ZA; Yeasmin, F, 2013) | 0.39 |
| " Refining estimates of the influence of these factors will permit better models of dose-response relations for this important environmental contaminant." | ( Biological and behavioral factors modify biomarkers of arsenic exposure in a U.S. population. Calderon, RL; Carty, C; He, B; Hudgens, EE; Le, XC; Rogers, J; Thomas, DJ, 2013) | 0.39 |
| " Significant dose-response relationships were found between decreased T and urinary Mn and Zn, even when considering multiple metals (both P for trend <0." | ( Associations of urinary metal concentrations and circulating testosterone in Chinese men. Feng, W; Li, YF; Liu, AL; Lu, WQ; Wang, YX; Yue, J; Zeng, Q; Zhou, B, 2013) | 0.39 |
| " This experimental design allows us to do microarray analysis of dose-response relationships of global gene expression patterns." | ( Genomic analysis of stress response against arsenic in Caenorhabditis elegans. Bozdag, S; Cinar, HN; Lee, JH; Lewis, J; Patel, I; Sahu, SN; Sprando, R, 2013) | 0.39 |
| " Among these, 14 transcripts were further confirmed for up-regulation by a lower dosage of arsenic in majority of individual zebrafish." | ( Genome-wide identification of molecular pathways and biomarkers in response to arsenic exposure in zebrafish liver. Gong, Z; Lam, SH; Shen, Y; Xu, H, 2013) | 0.39 |
| " After the spill, the water management authority initially focused on acid dosing of surface waters to lower pH and was effective in lowering both pH and metal(loid) concentrations." | ( Trace metal and metalloid levels in surface water of Marcal River before and after the Ajka red mud spill, Hungary. Nagy, AS; Szabó, J; Vass, I, 2013) | 0.39 |
| " The developed and validated method was shown to be reproducible for quantification of arsenic and antimony in liposome pharmaceutical dosage forms." | ( Development and validation of an analytical method for quantification of arsenic and antimony in liposomes using inductively coupled plasma-optical emission spectrometry. Abreu, AT; de Souza, J; Guimarães, AG; Reis, PG; Silva-Barcellos, NM; Teixeira, MC, ) | 0.13 |
| "The objective of this study was to examine the dose-response relationship between As and global methylation of peripheral blood mononuclear cell (PBMC) DNA in apparently healthy Bangladeshi adults chronically exposed to a wide range of As concentrations in drinking water." | ( A dose-response study of arsenic exposure and global methylation of peripheral blood mononuclear cell DNA in Bangladeshi adults. Alam, S; Gamble, MV; Graziano, JH; Hall, MN; Harper, KN; Ilievski, V; Levy, D; Liu, X; Mey, JL; Niedzwiecki, MM; Oka, J; Parvez, F; Siddique, AB; Slavkovich, V; van Geen, A, ) | 0.13 |
| " This MOA implies a non-linear, threshold dose-response relationship for both non-cancer and cancer end points." | ( Evaluation of the carcinogenicity of inorganic arsenic. Arnold, LL; Beck, BD; Cohen, SM; Eldan, M; Lewis, AS, 2013) | 0.39 |
| " Dose-response relationship was assessed by restricted cubic spline model and multivariate random-effect meta-regression." | ( Association of inorganic arsenic exposure with type 2 diabetes mellitus: a meta-analysis. Lin, Y; Wang, W; Xie, Z; Zhang, D, 2014) | 0.4 |
| " Dose-response analysis suggested T2DM risk increased by 13% (1." | ( Association of inorganic arsenic exposure with type 2 diabetes mellitus: a meta-analysis. Lin, Y; Wang, W; Xie, Z; Zhang, D, 2014) | 0.4 |
| " The findings of this study, which are limited by its small sample size and moderate dose-response relation, remain to be validated by further studies with large sample sizes." | ( Comparison of genome-wide DNA methylation in urothelial carcinomas of patients with and without arsenic exposure. Chang, CH; Chen, CJ; Chiu, AW; Hsu, LI; Lee, TC; Liao, YT; Pu, YS; Wang, SH; Wang, YH; Wu, MM; Yang, TY, 2014) | 0.4 |
| "07) µg/g Cr, respectively for the drinking water arsenic poisoning group, the low, medium and high dosage arsenic grain contamination groups, all higher than that in the control group (94." | ( [The regulation mechanism of protein kinase Cδ on arsenic liver injury caused by coal-burning]. Hu, Y; Huang, XX; Tang, XD; Yao, ML; Zhang, AH, 2013) | 0.39 |
| " Either TTHM or HAA individual dosing did not promote As release from either scales only or SBC, detecting <6 μg AsL(-1) in finished water." | ( Evidence of arsenic release promoted by disinfection by-products within drinking-water distribution systems. Andra, SS; Botsaris, G; Charisiadis, P; Costa, CN; Kalyvas, H; Makris, KC, 2014) | 0.4 |
| " The concentration of urinary As ([As]u) was associated with reduced intellectual function in a dose-response manner." | ( A consecutive study on arsenic exposure and intelligence quotient (IQ) of children in Bangladesh. Fujimura, M; Inaoka, T; Nahar, MN, 2014) | 0.4 |
| ", inadequate statistical power, exposure misclassification), or a different dose-response relationship at low exposures, possibly associated with a toxicological mode of action that requires a sufficient dose for increased tumor formation." | ( Arsenic exposure and bladder cancer: quantitative assessment of studies in human populations to detect risks at low doses. Alexander, DD; Mink, PJ; Perez, V; Tsuji, JS, 2014) | 0.4 |
| " Clinical therapeutic dosage of ATO was intraperitoneally injected into C57 mice, and the numbers of circulating platelets were significantly reduced after five days of continuous injection." | ( Arsenic trioxide induces apoptosis in human platelets via C-Jun NH2-terminal kinase activation. Dai, J; Dai, K; Ruan, C; Wu, Y; Yan, R; Zhang, W; Zhang, Y, 2014) | 0.4 |
| " Here, we present a probabilistic framework for assessing the human health risks from consuming raw and cooked fish that were cultured in groundwater As-contaminated ponds in Taiwan by linking a physiologically based pharmacokinetics model and a Weibull dose-response model." | ( Probabilistic framework for assessing the arsenic exposure risk from cooked fish consumption. Chen, SC; Chen, WY; Cheng, YH; Chio, CP; Liao, CM; Ling, MP; Wu, CH, 2014) | 0.4 |
| "To evaluate the dose-response relationship between arsenic (As) exposure and markers of oxidative damage in Bangladeshi adults." | ( A dose-response study of arsenic exposure and markers of oxidative damage in Bangladesh. Alam, S; Calancie, L; Gamble, MV; Graziano, JH; Hall, MN; Harper, KN; Ilievski, V; Levy, D; Liu, X; Mey, JL; Oka, J; Siddique, A; Slavkovich, V; van Geen, A, 2014) | 0.4 |
| "With the increase of sodium arsenite or arsenic trioxide concentrations, cellular viability, colony formation rate and GSH contents decreased; inhibition of colony formation, cellular apoptotic rate, reactive oxygen species level and frequency of micronuclei increased, and dosed cells were both arrested in G2/M phase of cell cycle." | ( [Research on the sodium arsenite and arsenic trioxide induced proliferation and apoptosis effects on human hepatocyte]. Chen, C; Hu, Y; Jiang, X; Zhang, Z; Zhao, W, 2014) | 0.4 |
| "In the recent National Research Council report on conducting a dose-response assessment for inorganic arsenic, the committee remarked that mode of action data should be used, to the extent possible, to extrapolate below the observed range for epidemiological studies to inform the shape of the dose-response curve." | ( Use of mode of action data to inform a dose-response assessment for bladder cancer following exposure to inorganic arsenic. Clewell, HJ; Clewell, RA; Gentry, PR; Yager, JW, 2014) | 0.4 |
| "002), possibly in a dose-response relationship." | ( Exposure to arsenic and intra-chromosomal instability in blood. Bottai, M; Broberg, K; Vahter, M; Wojdacz, TK, 2014) | 0.4 |
| " In this study, we treated human cells with arsenic (As), copper or selenium (Se) in a dose-response manner and used attenuated total reflection Fourier-transform infrared (ATR-FTIR) microspectroscopy combined with computational analysis to examine cellular alterations." | ( Bimodal responses of cells to trace elements: insights into their mechanism of action using a biospectroscopy approach. Hoti, V; Llabjani, V; Martin, FL; Pouran, HM; Zhang, H, 2014) | 0.4 |
| " To achieve an equivalent effect, a 10-fold dosage of genistein was required, thus highlighting the dose advantage of resveratrol, as poor bioavailability is a common concern for its clinical application." | ( Arsenic trioxide and resveratrol show synergistic anti-leukemia activity and neutralized cardiotoxicity. Chen, M; Fan, Y; Fang, K; Meng, J; Tu, Y; Wan, L; Yu, L; Zhu, W, 2014) | 0.4 |
| "3 µM) dosage increased lysosomal activity and induced autophagy and higher (1." | ( Realgar (As4S4) nanoparticles and arsenic trioxide (As2O3) induced autophagy and apoptosis in human melanoma cells in vitro. Balaz, P; Bujnakova, Z; Cholujova, D; Duraj, J; Gronesova, P; Hunakova, L; Lee, TC; Pastorek, M; Sedlak, J, 2014) | 0.4 |
| " Further, VEGF levels showed dose-response relationships with water, hair and nail arsenic." | ( Associations of total arsenic in drinking water, hair and nails with serum vascular endothelial growth factor in arsenic-endemic individuals in Bangladesh. Al Amin, H; Al Mamun, A; Himeno, S; Hossain, K; Hossain, MI; Hossain, S; Islam, K; Karim, MR; Miyataka, H; Noman, AS; Rahman, M; Saud, ZA, 2015) | 0.42 |
| " There were dose-response relationships between arsenic exposure and PUA levels." | ( Elevated levels of plasma uric acid and its relation to hypertension in arsenic-endemic human individuals in Bangladesh. Aktar, S; Alam, S; Ali, N; Arefin, A; Aziz, A; Himeno, S; Hossain, K; Hossain, MI; Hossain, S; Huda, N; Islam, K; Karim, MR; Mamun, AA; Miyataka, H; Mohanto, NC; Rahman, M; Salam, KA; Saud, ZA, 2014) | 0.4 |
| " Despite these differences, all were developed based on a cumulative exposure metric assuming a low-dose linear dose-response relationship." | ( Considerations in deriving quantitative cancer criteria for inorganic arsenic exposure via inhalation. Beyer, LA; Lewis, AS; Zu, K, 2015) | 0.42 |
| "To determine the potential for arsenic trioxide (ATO) to be safely and effectively incorporated into induction therapy of newly diagnosed acute promyelocytic leukaemia (APL) in patients with severe chronic renal failure (CRF) by reduction of the ATO dosage to compensate for reduced renal elimination of arsenic in CRF." | ( Dose-adjusted arsenic trioxide for acute promyelocytic leukaemia in chronic renal failure. Firkin, F; Ho, WK; Roncolato, F, 2015) | 0.42 |
| " ATO dosage schedules were adjusted to obtain comparable whole-blood arsenic levels to those in APL patients with normal renal function who achieved molecular remission (MR) while receiving 10 mg ATO daily for 28 d." | ( Dose-adjusted arsenic trioxide for acute promyelocytic leukaemia in chronic renal failure. Firkin, F; Ho, WK; Roncolato, F, 2015) | 0.42 |
| "The observations in this pilot study have demonstrated whole-blood arsenic levels can provide a guide to adjustments of ATO dosage schedules that permit safe and effective therapeutic outcomes in APL patients with severely compromised renal function." | ( Dose-adjusted arsenic trioxide for acute promyelocytic leukaemia in chronic renal failure. Firkin, F; Ho, WK; Roncolato, F, 2015) | 0.42 |
| " A dose-response relationship was observed between UA levels and inattention and impulsivity scores." | ( Postnatal arsenic exposure and attention impairment in school children. Aguilar-Garduño, C; Alguacil, J; Gil, F; Gómez, I; González-Alzaga, B; Hernández, AF; Lacasaña, M; Lorca, A; Mendoza, R; Molina-Villalba, I; Rodríguez-Barranco, M; Rohlman, DS, 2016) | 0.43 |
| " Based on this analysis, we conclude that there are no data supporting a linear dose-response relationship between iAs and CVD, indicating this relationship has a threshold." | ( Mechanisms of action for arsenic in cardiovascular toxicity and implications for risk assessment. Beck, BD; Desai, KP; Lynch, HN; Rhomberg, LR; Sidhu, MS; Venditti, FJ, 2015) | 0.42 |
| " The connection between arsenic dosage and inflammation-related genes was assessed." | ( Inflammatory Factor Alterations in the Gastrointestinal Tract of Cocks Overexposed to Arsenic Trioxide. Chai, H; Guo, G; Guo, Y; He, Y; Tian, L; Xing, M; Zhang, K; Zhang, W; Zhao, P, 2015) | 0.42 |
| "99 mg g-1 was achieved within 26 h for a solution containing 12 mg L-1 As(III) at pH 4 and sorbent dosage of 2 g L-1." | ( Enhanced adsorption of trivalent arsenic from water by functionalized diatom silica shells. Ding, T; Xu, L; Zhang, C; Zhang, J; Zhang, Z, 2015) | 0.42 |
| " Dose adjustments are recommended to be considered in severe renal impairment although dosage reduction guidelines are not provided." | ( Use of arsenic trioxide in a hemodialysis-dependent patient with relapsed acute promyelocytic leukemia. Eyler, R; Moeller, J; Patel, K; Perreault, S; Pham, T; Podoltsev, N; Russell, K, 2016) | 0.43 |
| " Restricted cubic spline analysis was performed to help assess linearity and nature of any dose-response relationships." | ( Exposure to phthalates, bisphenol A and metals in pregnancy and the association with impaired glucose tolerance and gestational diabetes mellitus: The MIREC study. Arbuckle, TE; Ashley-Martin, J; Bouchard, MF; Dallaire, R; Dodds, L; Ettinger, AS; Fisher, M; Fraser, W; Keely, E; Monnier, P; Morisset, A; Shapiro, GD; Taback, S, 2015) | 0.42 |
| " coli) attenuation by Fe-EC in synthetic Bengal groundwater as a function of Fe dosage rate, total Fe dosed, pH, and presence of natural organic matter (NOM)." | ( Escherichia coli Attenuation by Fe Electrocoagulation in Synthetic Bengal Groundwater: Effect of pH and Natural Organic Matter. Amrose, SE; Delaire, C; Gadgil, AJ; Nelson, KL; van Genuchten, CM, 2015) | 0.42 |
| " For skin lesions, a consistent dose-response relationship with water arsenic has been observed, with increased risk evident at low- to moderate-dose exposure." | ( Drinking Water Arsenic Contamination, Skin Lesions, and Malignancies: A Systematic Review of the Global Evidence. Ahsan, H; Gossai, A; Karagas, MR; Pierce, B, 2015) | 0.42 |
| " Organisms were exposed by dissolving chemicals in seawater (salinity = 30) at nominal concentrations of 10 μg/L nTiO2 or As(III), dosed alone and in combination." | ( Evaluation of coexposure to inorganic arsenic and titanium dioxide nanoparticles in the marine shrimp Litopenaeus vannamei. Cordeiro, L; Fattorini, D; Gelesky, MA; Monserrat, JM; Müller, L; Regoli, F; Ventura-Lima, J; Wasielesky, W, 2016) | 0.43 |
| " As(V) concentrations in solution increased along with the elevated H2O2 dosage level." | ( Arsenic release from the abiotic oxidation of arsenopyrite under the impact of waterborne H2O2: a SEM and XPS study. Ma, Y; Qin, Y; Zhang, L; Zhao, Y; Zheng, B, 2016) | 0.43 |
| " A flexible non-parametric approach was used to investigate dose-response relationships." | ( Arsenic in Drinking Water and Mortality for Cancer and Chronic Diseases in Central Italy, 1990-2010. D'Ippoliti, D; Davoli, M; De Sario, M; Michelozzi, P; Santelli, E; Scortichini, M, 2015) | 0.42 |
| " For lung cancer and cardiovascular diseases dose-response relationship is modelled by piecewise linear functions revealing effects even for doses lower than 10 μg/L, and no threshold dose value was identified as safe for health." | ( Arsenic in Drinking Water and Mortality for Cancer and Chronic Diseases in Central Italy, 1990-2010. D'Ippoliti, D; Davoli, M; De Sario, M; Michelozzi, P; Santelli, E; Scortichini, M, 2015) | 0.42 |
| " Although the overall evidence does not consistently show a causal dose-response relationship at low doses, the most rigorously conducted studies from Bangladesh indicate possible inverse associations with cognitive function, predominantly involving concurrent arsenic exposure as measured by biomarkers (i." | ( Low-level arsenic exposure and developmental neurotoxicity in children: A systematic review and risk assessment. Chang, ET; Garry, MR; Perez, V; Tsuji, JS, 2015) | 0.42 |
| " studies available, the most rigorously conducted study did not find a consistent dose-response relationship between arsenic concentrations in tap water or toenails and decrements in IQ scores." | ( Low-level arsenic exposure and developmental neurotoxicity in children: A systematic review and risk assessment. Chang, ET; Garry, MR; Perez, V; Tsuji, JS, 2015) | 0.42 |
| " This strategy significantly improved spectra classification, consistent with a dose-response effect of the four tested concentrations of the metal." | ( Potential of Raman Spectroscopy To Monitor Arsenic Toxicity on Bacteria: Insights toward Multiparametric Bioassays. Assaf, A; Bittel, M; Cordella, CB; Durand, MJ; Jouanneau, S; Thouand, G, 2015) | 0.42 |
| "In earlier analyses, we demonstrated dose-response relationships between renal and lung cancer and local arsenic concentrations in wells used by Bangladeshi villagers." | ( Arsenic in Drinking Water, Transition Cell Cancer and Chronic Cystitis in Rural Bangladesh. Cherry, N; Mostafa, MG, 2015) | 0.42 |
| "This study showed the significant positive associations and dose-response relationships of arsenic exposure with serum MMP-2 and MMP-9 concentrations." | ( Elevated concentrations of serum matrix metalloproteinase-2 and -9 and their associations with circulating markers of cardiovascular diseases in chronic arsenic-exposed individuals. Aktar, S; Aziz, A; Haque, A; Himeno, S; Hoque, MM; Hossain, K; Hossain, M; Islam, MS; Jahan, M; Karim, MR; Khatun, R; Mandal, A; Miyataka, H; Mohanto, NC; Rahman, A; Salam, KA; Saud, ZA, 2015) | 0.42 |
| " We have sought the epidemiological studies that have examined the dose-response relationship between arsenic levels in drinking water and the risk of lung cancer over a range that includes both high and low levels of arsenic." | ( A Systematic Review and Meta-Regression Analysis of Lung Cancer Risk and Inorganic Arsenic in Drinking Water. Ahn, J; Dissen, EK; Ferdosi, H; Lamm, SH; Li, J, 2015) | 0.42 |
| " Urinary total arsenic level was significantly associated with the risk of RCC in a dose-response manner, but it was not related to the recurrence of RCC." | ( Joint Effect of Urinary Total Arsenic Level and VEGF-A Genetic Polymorphisms on the Recurrence of Renal Cell Carcinoma. Chen, WJ; Hsueh, YM; Huang, CY; Huang, SP; Lin, YC; Pu, YS; Shiue, HS; Yang, SM, 2015) | 0.42 |
| "62), and there was evidence of a dose-response relationship for green and herbal tea." | ( Is there a relationship between tea intake and maternal whole blood heavy metal concentrations? Arbuckle, TE; Colapinto, CK; Dubois, L; Fraser, W, 2016) | 0.43 |
| " For participants that received ⩾2 vaccine doses or did not know if they had received any doses, a positive dose-response association was observed between increasing TUA1 and odds of total anti-HAV [odds ratio (OR) 1·42, 95% CI 1·11-1·81; and OR 1·75, 95% CI 1·22-2·52], respectively." | ( Arsenic exposure and the seroprevalence of total hepatitis A antibodies in the US population: NHANES, 2003-2012. Bethel, JW; Cardenas, A; Houseman, EA; Kile, ML; Smit, E, 2016) | 0.43 |
| "03ng/g were associated with increased risk for almost every CHD subtype, with a dose-response relationship." | ( Maternal exposure to arsenic and cadmium and the risk of congenital heart defects in offspring. Deng, Y; Hu, H; Jin, X; Li, N; Li, X; Liu, Z; Tian, X; Zhu, J, 2016) | 0.43 |
| " Continuous dosing may be required to fully inhibit the HH pathway and achieve clinical response." | ( Effects of Combined Treatment With Arsenic Trioxide and Itraconazole in Patients With Refractory Metastatic Basal Cell Carcinoma. Ally, MS; Atwood, SX; Bailey-Healy, I; Beachy, PA; Chang, AL; Colevas, AD; Kim, J; Oro, A; Ransohoff, K; Rezaee, M; Sarin, K; Tang, JY, 2016) | 0.43 |
| "A batch experiment was conducted to investigate the mobilization of soil-borne arsenic by three common low-molecular-weight organic acids with a focus on dosage and time effects." | ( Mobilization of soil-borne arsenic by three common organic acids: Dosage and time effects. Lin, C; Onireti, OO, 2016) | 0.43 |
| "5 μg kg(-1) day(-1)) was considered a reason of the absence of adverse effects on semen parameters, which were seen in rodents dosed with 4-7." | ( Urinary inorganic arsenic concentrations and semen quality of male partners of subfertile couples in Tokyo. Hatakeyama, S; Mizumoto, Y; Oguri, T; Tokuoka, S; Toshima, H; Yoshinaga, J, 2016) | 0.43 |
| " In addition, the contents of total arsenic and arsenic species in earthworms were also determined to investigate the effects of bioaccumulation and biotransformation of arsenic on biomarkers and to evaluate the dose-response relationships." | ( Toxicological and biochemical responses of the earthworm Eisenia fetida exposed to contaminated soil: Effects of arsenic species. Cui, Z; Liu, L; Ma, Q; Wang, Z; Xu, X, 2016) | 0.43 |
| " There was a significant linear dose-response relationship observed between mean arsenic levels and prostate cancer incidence (p for trend=0." | ( Arsenic in drinking water and prostate cancer in Illinois counties: An ecologic study. Argos, M; Bulka, CM; Jones, RM; Stayner, LT; Turyk, ME, 2016) | 0.43 |
| " Hence, identifying biological and behavioral factors that modify an individual's capacity to methylate inorganic arsenic could provide insights into critical dose-response relations underlying adverse health effects." | ( Biological and behavioral factors modify urinary arsenic metabolic profiles in a U.S. population. Drobna, Z; He, B; Hudgens, EE; Le, XC; Rogers, J; Styblo, M; Thomas, DJ, 2016) | 0.43 |
| "These findings suggest that analyses of dose-response relations in arsenic-exposed populations should account for biological and behavioral factors that modify levels of inorganic and methylated arsenicals in urine." | ( Biological and behavioral factors modify urinary arsenic metabolic profiles in a U.S. population. Drobna, Z; He, B; Hudgens, EE; Le, XC; Rogers, J; Styblo, M; Thomas, DJ, 2016) | 0.43 |
| " Participants with the high-risk genotype of DNMT1 rs8101626 and DNMT3A rs34048824 with concurrently high urinary total arsenic levels had even higher OR of ccRCC in a dose-response manner." | ( Combined effects of DNA methyltransferase 1 and 3A polymorphisms and urinary total arsenic levels on the risk for clear cell renal cell carcinoma. Chen, WJ; Hsieh, YH; Hsueh, YM; Huang, CY; Lin, YC; Pu, YS; Shiue, HS; Yang, SM, 2016) | 0.43 |
| " Linear regression was performed for each phenotype, dependent on allele dosage of the variant." | ( Association of Cardiometabolic Genes with Arsenic Metabolism Biomarkers in American Indian Communities: The Strong Heart Family Study (SHFS). Balakrishnan, P; Best, LG; Cole, SA; Franceschini, N; Francesconi, KA; Goessler, W; Gribble, MO; Haack, K; Kent, J; Laston, S; Lee, E; MacCluer, JW; Navas-Acien, A; North, KE; Umans, JG; Vaidya, D; Voruganti, VS; Yracheta, J, 2017) | 0.46 |
| "35g/kg) dosage realgar exposed groups." | ( Chen, M; Fang, Y; Feng, C; Huo, T; Jiang, H; Wang, S; Wang, Y; Xiong, Z; Yuan, M; Zhang, Y; Zhao, L, 2016) | 0.43 |
| " The concentrations of both MMDTA(V) and DMDTA(V) in rat urine were dependent on the dosage of iAs(III) in diet." | ( Identification of Methylated Dithioarsenicals in the Urine of Rats Fed with Sodium Arsenite. Arnold, LL; Chen, B; Cohen, SM; Le, XC; Lu, X, 2016) | 0.43 |
| " Our findings suggest that dosing Fe(II) by an iron anode is an effective means to enhance As removal in a sand filter." | ( Iron-Anode Enhanced Sand Filter for Arsenic Removal from Tube Well Water. Gan, Y; Liao, P; Tong, M; Wang, Y; Xie, S; Yuan, S, 2017) | 0.46 |
| " The probabilistic risk assessment (PRA) technique was applied to characterize risk of CVD due to arsenic exposure by estimating the overlapping coefficient between dose-response and exposure distribution curves." | ( Cardiovascular risk from water arsenic exposure in Vietnam: Application of systematic review and meta-regression analysis in chemical health risk assessment. Chu, C; Connell, D; Phung, D; Rutherford, S, 2017) | 0.46 |
| " A dose-response experiment was performed with this material following OCDE 208 test." | ( Synergic use of chemical and ecotoxicological tools for evaluating multi-contaminated soils amended with iron oxides-rich materials. Esteban, E; Jiménez-Peñalver, P; Manzano, R, 2017) | 0.46 |
| "We reveal that low dosage of arsenic treatment increased cell proliferation is associated with accumulated cell population at S phase." | ( Arsenic treatment increase Aurora-A overexpression through E2F1 activation in bladder cells. Kao, YT; Lan, SH; Liu, HS; Tseng, YS; Wu, CH; Wu, SY, 2017) | 0.46 |
| " While we derived these factors assuming a linear, no-threshold relationship between iAs and cancer risk, we also evaluated the shape of the dose-response curves and assessed the evidence for overall nonlinearity." | ( Quantitative assessment of lung and bladder cancer risk and oral exposure to inorganic arsenic: Meta-regression analyses of epidemiological data. Kennedy, EM; Lam, T; Liu, X; Loftus, CT; Lynch, HN; Pizzurro, DM; Rhomberg, LR; Zu, K, 2017) | 0.46 |
| " We aimed to evaluate the dose-response associations between fasting plasma glucose (FPG) and multiple urinary metals including nickel, cobalt, copper, zinc, and arsenic, as well as to examine their joint effects among occupational workers." | ( Dose-response analysis of environmental exposure to multiple metals and their joint effects with fasting plasma glucose among occupational workers. Bai, Y; Cheng, N; Cheng, Z; Ding, J; Hu, X; Li, H; Li, J; Liu, S; Pu, H; Ren, X; Yang, A; Yang, K; Zheng, T, 2017) | 0.46 |
| " Both spline and categorical analyses were used to evaluate the dose-response relationship between urinary metals levels and FPG." | ( Dose-response analysis of environmental exposure to multiple metals and their joint effects with fasting plasma glucose among occupational workers. Bai, Y; Cheng, N; Cheng, Z; Ding, J; Hu, X; Li, H; Li, J; Liu, S; Pu, H; Ren, X; Yang, A; Yang, K; Zheng, T, 2017) | 0.46 |
| " Dose-response relationships were also observed for maternal UtAs exposure and birth outcomes." | ( Associations between urinary total arsenic levels, fetal development, and neonatal birth outcomes: A cohort study in Taiwan. Chang, CH; Chen, ML; Chien, LC; Chung, MY; Liao, KW; Mao, IF; Tsai, MS; Tsai, YA, 2018) | 0.48 |
| " The doses at which these genomic and epigenomic changes occur have yet to be evaluated in the context of dose-response modeling." | ( Benchmark Dose Modeling Estimates of the Concentrations of Inorganic Arsenic That Induce Changes to the Neonatal Transcriptome, Proteome, and Epigenome in a Pregnancy Cohort. Auerbach, SS; Chappell, GA; Fry, RC; Martin, E; Rager, JE; Thompson, CM, 2017) | 0.46 |
| " The shape of the dose-response across low-moderate and high levels of arsenic in drinking water is uncertain and critical for risk assessment." | ( A dose-response meta-analysis of chronic arsenic exposure and incident cardiovascular disease. Ahsan, H; Barchowsky, A; Chen, Y; D'Ippoliti, D; Farzan, SF; Guallar, E; James, KA; Karagas, MR; Moon, KA; Nachman, KE; Navas-Acien, A; Oberoi, S; Rahman, M; Sohel, N; Wade, TJ, 2017) | 0.46 |
| " In a dose-response meta-analysis, we estimated the pooled association between log-transformed water arsenic (log-linear) and restricted cubic splines of log-transformed water arsenic (non-linear) and the relative risk of each CVD endpoint." | ( A dose-response meta-analysis of chronic arsenic exposure and incident cardiovascular disease. Ahsan, H; Barchowsky, A; Chen, Y; D'Ippoliti, D; Farzan, SF; Guallar, E; James, KA; Karagas, MR; Moon, KA; Nachman, KE; Navas-Acien, A; Oberoi, S; Rahman, M; Sohel, N; Wade, TJ, 2017) | 0.46 |
| " We explored human carcinogenic and non-carcinogenic disease tradeoffs of water treatment by comparing pollutant dose-response curves against life cycle burden using USEtox methodology." | ( Human health tradeoffs in wellhead drinking water treatment: Comparing exposure reduction to embedded life cycle risks. Chester, M; Gifford, M; Hristovski, K; Westerhoff, P, 2018) | 0.48 |
| " Thus, the present data strongly indicate that low dosage As2O3 reduces the formation of VM in HB cell line HepG2 cells, independent of cell apoptosis in vivo and in vitro, and may represent as a candidate drug for HB targeting VM." | ( Low dosage of arsenic trioxide inhibits vasculogenic mimicry in hepatoblastoma without cell apoptosis. Fu, Y; Guo, BB; Jiang, HY; Li, S; Liu, LY; Wang, KK; Wu, CJ; Zhang, CM; Zhang, F; Zhang, Y, 2018) | 0.48 |
| " In vitro dose-response analysis also confirmed the association of the H3K79me1 signature with arsenic toxicity." | ( Association of H3K79 monomethylation (an epigenetic signature) with arsenic-induced skin lesions. Bhattacharjee, P; Bhattacharjee, S; Giri, AK; Paul, S, 2018) | 0.48 |
| " Cell viability was detected by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and the appropriate dosage and time were screened." | ( Mechanism of As2O3 induces apoptosis of glioma U87 cells. Hu, J; Liu, JH; Wang, GB; Xue, K, 2017) | 0.46 |
| " After adjusting for potential confounders, detectable As levels were associated with decrements in global and verbal executive functions and quantitative abilities; detectable Hg was associated with lower scores on the verbal function of posterior cortex in a dose-response manner, and non-linearly related to poorer motor function and gross motor skills; and Mn levels were associated with decrement in perceptual-performance skills in a dose-response manner but with better memory span and quantitative skills." | ( Prenatal co-exposure to neurotoxic metals and neurodevelopment in preschool children: The Environment and Childhood (INMA) Project. Amaya, E; Andiarena, A; Aurrekoetxea, J; Bustamante, M; Ezama, E; Fernández, MF; Fernández-Tardón, G; Freire, C; Gil, F; Guxens, M; Llop, S; Murcia, M; Olea, N, 2018) | 0.48 |
| "This study was conducted in rural Pakistan to assess the dose-response relationship between skin lesions and arsenic exposure and their variation by demographic characteristics." | ( The effect of association between inefficient arsenic methylation capacity and demographic characteristics on the risk of skin lesions. Gong, YY; Kay, P; Rasheed, H; Slack, R, 2018) | 0.48 |
| "2mg/kg/day, suggesting the absence of a linear dose-response relationship between the dose and deposition of DPAA(V)." | ( High-sensitivity quantitative analysis reveals the non-linear relationship between the dose and deposition of diphenylarsinic acid in the rat central nervous system following its subchronic exposure. Ishii, K; Iwasaki, N; Masuda, T; Nakayama, T; Shibata, Y; Tamaoka, A, ) | 0.13 |
| " Quantitation of arsenic species in diets used in studies in which drinking water is the nominal source of arsenic exposure provides more accurate dosimetry and improves understanding of dose-response relations." | ( Dose and Diet - Sources of Arsenic Intake in Mouse in Utero Exposure Scenarios. Elek, B; Francesconi, KA; Murko, M; Styblo, M; Thomas, DJ, 2018) | 0.48 |
| " Our data further showed that the conventional dosage of ATO reached a plasma concentration substantially below the required concentration to inhibit platelets." | ( Arsenic trioxide at conventional dosage does not aggravate hemorrhage in the first-line treatment of adult acute promyelocytic leukemia. Chen, L; Chen, SJ; Chen, Z; Cui, W; Gao, MQ; Hu, J; Li, JM; Mi, JQ; Nie, RM; Shen, ZX; Wang, J; Wang, KK; Wang, ZY; Xi, XD; Zhao, LL; Zhu, HM, 2018) | 0.48 |
| " Secondly, we also showed that RTS could induce autophagy via up-regulation of LC3, p62/SQSTM1 and inhibition of mTOR in a much lower arsenic dosage in contrast to ATO and realgar." | ( Autophagy enhanced antitumor effect in K562 and K562/ADM cells using realgar transforming solution. Chen, B; Hai, Y; Inam, U; Li, H; Li, Y; Song, P; Wang, X; Wu, Z; Xie, Q; Yu, L; Zhao, L; Zhi, D, 2018) | 0.48 |
| " MGO dosage and initial pH were the most significant parameters influencing the process performance." | ( Synthesis and characterization of magnetic graphene oxide for arsenic removal from aqueous solution. Bello, MM; Raman, AAA; Sherlala, AIA, 2019) | 0.51 |
| " Plants dosed with 5 μM DMA grew well vegetatively but exhibited straighthead disorder at the lowest Si dose, and this DMA-induced yield loss reversed with increasing solution Si." | ( Silicon Decreases Dimethylarsinic Acid Concentration in Rice Grain and Mitigates Straighthead Disorder. Dykes, GE; Limmer, MA; Seyfferth, AL; Wise, P, 2018) | 0.48 |
| " Inefficient arsenic methylation capacity (high monomethylarsonic acid percentage [MMA%] and low dimethylarsinic acid percentage [DMA%]) was associated with increased risk of BC in a dose-response relationship." | ( Polymorphisms of Arsenic (+3 Oxidation State) Methyltransferase and Arsenic Methylation Capacity Affect the Risk of Bladder Cancer. Ao, PL; Chen, WJ; Hsueh, YM; Huang, CY; Lin, YC; Pu, YS; Shiue, HS; Su, CT, 2018) | 0.48 |
| " We found that inefficient arsenic methylation capacity was associated with BC in a significant dose-response relationship, but only found that high urinary total arsenic concentration was related to the risk of UTUC, also in a significant dose-response manner." | ( Comparison of arsenic methylation capacity and polymorphisms of arsenic methylation genes between bladder cancer and upper tract urothelial carcinoma. Ao, PL; Chen, WJ; Hsueh, YM; Huang, CY; Lin, YC; Pu, YS; Shiue, HS; Su, CT, 2018) | 0.48 |
| " Physiologically based pharmacokinetic (PBPK) models may be used to obtain a common exposure metric for application in dose-response meta-analysis." | ( Evaluation of a Physiologically Based Pharmacokinetic (PBPK) Model for Inorganic Arsenic Exposure Using Data from Two Diverse Human Populations. El-Masri, HA; Henning, C; Hong, T; Hudgens, EE; Lee, JS; Mendez, W; Thomas, DJ, 2018) | 0.48 |
| " The dosage was continually given to the pups until postnatal day (PND) 42." | ( Arsenic-Induced Autophagy in the Developing Mouse Cerebellum: Involvement of the Blood-Brain Barrier's Tight-Junction Proteins and the PI3K-Akt-mTOR Signaling Pathway. Manthari, RK; Niu, R; Ommati, MM; Sun, Z; Tikka, C; Wang, J; Zhang, J, 2018) | 0.48 |
| " After ripening, enhanced As removal was achieved with a top layer of coarse media or by dosing additional Fe(III)." | ( As(III) removal in rapid filters: Effect of pH, Fe(II)/Fe(III), filtration velocity and media size. Gude, JCJ; Rietveld, LC; van Halem, D, 2018) | 0.48 |
| " Animal models evaluating whole-life exposure to inorganic arsenic must use direct dosing in early neonatal life to predict accurately potential toxicity from early life exposures in children." | ( Metabolism and disposition of arsenic species from oral dosing with sodium arsenite in neonatal CD-1 mice. IV. Toxicokinetics following gavage administration and lactational transfer. Beland, FA; Doerge, DR; Fisher, JW; Twaddle, NC; Vanlandingham, M, 2019) | 0.51 |
| " We recommend that veterinarians prescribe the recommended 10 mg/kg doxycycline for canine heartworm treatment and reduce the dosage to 5 mg/kg in cases of severe gastrointestinal side effects in order to improve owner compliance in administration of medications." | ( Efficacy and side effects of doxycycline versus minocycline in the three-dose melarsomine canine adulticidal heartworm treatment protocol. Bradner, JL; Day, KM; Dzimianski, MT; Moorhead, AR; Savadelis, MD; Wolstenholme, AJ, 2018) | 0.48 |
| " The results indicated that there was a competitive interaction between As(III) and DBP removal, and 40 mg/kg of Mn(II) dosage and 20%-30% soil moisture content were recommended for optimal and simultaneous removal of As(III) and DBP." | ( Simultaneous remediation of As(III) and dibutyl phthalate (DBP) in soil by a manganese-oxidizing bacterium and its mechanisms. Duo, J; He, Z; Li, Z; Pan, X; Wei, Z; Zhang, Q, 2019) | 0.51 |
| " An increase in the PC scores for the third aesthetic objective in private wells (characterized primarily by iron and manganese) was associated with decreased diabetes incidence, although a meaningful dose-response relationship was not evident." | ( Bayesian Hierarchical Models as Tools to Evaluate the Association Between Groundwater Quality and the Occurrence of Type 2 Diabetes in Rural Saskatchewan, Canada. Bharadwaj, L; Epp, TY; McLeod, L; Waldner, CL, 2019) | 0.51 |
| " Even though the "number" dosage of arsenic in the limited ventilation living room fire was similar to the "number" dosage of chromium in the living room, particle mass and surface area dosages simulated in the limited living room were 90-200 fold higher than that in the ventilated living room." | ( Fate of the inhaled smoke particles from fire scenes in the nasal airway of a realistic firefighter: A simulation study. Shang, Y; Tian, L; Tu, J; Weng, W; Xu, X, 2019) | 0.51 |
| " The dose-response relationship showed that low dose (≤5 μmol/L) arsenic exposure up-regulated the expression of TGF-β1, whereas high doses had a tendency to down-regulate that of TGF-β1." | ( Bi-directional regulation of TGF-β/Smad pathway by arsenic: A systemic review and meta-analysis of in vivo and in vitro studies. Dai, J; Hu, Y; Li, S; Li, Y; Niu, Q; Xu, M; Zhang, X, 2019) | 0.51 |
| " There was no dose-response relationship between maternal hair arsenic concentration and the risk of total NTDs." | ( Association of maternal chronic arsenic exposure with the risk of neural tube defects in Northern China. Cheng, H; Li, Z; Ren, A; Wang, B; Wang, X; Yan, L; Ye, R; Zhang, J; Zhu, Y, 2019) | 0.51 |
| " To explore the biological exposure limits for mixed exposures of fluoride and arsenic, we compared the contents of fluorine and arsenic in the environmental media of the control and fluoride-arsenic combined exposure areas and analyzed the dose-effect and dose-response relationship between fluoride, arsenic and the key proteins of Wnt signaling pathways." | ( [Biological exposure limits caused by co exposure to fluoride and arsenic based on Wnt signaling pathway]. Hong, F; Tu, CL; Xu, YY; Yang, J; Yu, X; Zeng, QB, 2019) | 0.51 |
| " Such non-monotonic dose-response effects of iAs on glucose tolerance shed light on the complex interactions between iAs and the systemic glucose metabolism, which could potentially help reconcile some of the conflicting results in human epidemiological studies." | ( Non-monotonic dose-response effects of arsenic on glucose metabolism. Ding, G; Gong, Y; Li, X; Liu, J; Qian, J; Qian, S; Sun, Z; Xue, Y; Zhou, W; Zhuang, Z, 2019) | 0.51 |
| " Log-binomial regression model and two-piece-wise regression model were applied to assess the dose-response relationship between metal exposure and hypertension." | ( Urinary metal/metalloid levels in relation to hypertension among occupationally exposed workers. Jing, H; Shi, P; Xi, S, 2019) | 0.51 |
| " The exposure dose-response relationship was observed in various organs including neurological systems." | ( Arsenic Neurotoxicity in Humans. Mochizuki, H, 2019) | 0.51 |
| " To estimate cancer and cardiovascular disease burden, we developed a Monte Carlo model integrating three input streams: (1) regional concentrations of arsenic in drinking water wells across the United States; (2) dose-response relationships in the form of cancer slope factors and hazard ratios; and (3) economic cost estimates developed for morbidity endpoints using 'cost-of-illness' methods and for mortality using 'value per statistical life' estimates." | ( Estimated burden of disease from arsenic in drinking water supplied by domestic wells in the United States. Backer, L; Belova, A; Greco, SL; Haskell, J, 2019) | 0.51 |
| " Plants of maize, rice, sorghum, common bean, sunflower, and radish were cultivated in two different tropical soils (Oxisol and Inceptisol) and in a standard substrate (tropical artificial soil - TAS) dosed with As (0; 8; 14." | ( Assessing the Brazilian prevention value for soil arsenic: Effects on emergence and growth of plant species relevant to tropical agroecosystems. Bundschuh, J; de Oliveira, C; Guilherme, LRG; Martins, GC; Natal-da-Luz, T; Ribeiro, PG; Sousa, JP, 2019) | 0.51 |
| " Unlike acute toxic exposure, the classical dose-response relationship is not adequate for estimating the possible impact of chronic low-level arsenic exposure." | ( Developmental toxicity of arsenic: a drift from the classical dose-response relationship. Aaseth, J; Bjørklund, G; Rahaman, MS; Tippairote, T, 2020) | 0.56 |
| " Specifically, monotonic negative dose-response relationships were observed between H-As and FEV1(%), FEV1/FVC (%) and FEF75 (%) (all P < 0." | ( Human arsenic exposure and lung function impairment in coal-burning areas in Guizhou, China. Wang, Q; Wang, W; Zhang, A; Zheng, F; Zou, Z, 2020) | 0.56 |
| " Globally, metal- and As-induced oxidative stress is least emphasized in multiple tissues of birds that is needed to be addressed with focus on case-control studies using dose-response approach." | ( Oxidative stress risk assessment through heavy metal and arsenic exposure in terrestrial and aquatic bird species of Pakistan. Abbasi, NA; Ahmad, SR; Chaudhry, MJI; Kanwal, S; Malik, RN, 2020) | 0.56 |
| " Two cohorts of 20 singly housed, shaved, dermatitis free, adult male CD1 mice were dosed daily for 2 wk by topical application of saline or green clay paste." | ( Elevated Arsenic and Lead Concentrations in Natural Healing Clay Applied Topically as a Treatment for Ulcerative Dermatitis in Mice. Bradham, KD; Brar, SS; DeVito, MJ; Kissling, GE; Kurtz, DM; Nelson, CM; Qu, W; Travlos, GS; Whiteside, TE, 2020) | 0.56 |
| " Further, we found that As reduction to below 1 μg/L can be effectively achieved at water treatment plants either by treating the influent of rapid sand filters by dosing potassium permanganate in combination with ferric chloride or by treating the effluent of rapid sand filters with ferric chloride dosing only." | ( Mobility and redox transformation of arsenic during treatment of artificially recharged groundwater for drinking water production. Ahmad, A; Battaglia-Brunet, F; Bhattacharya, P; de Waal, L; Heijnen, L; Oorthuizen, W; Pieterse, B; van der Wal, A, 2020) | 0.56 |
| " As such, there are "pre-analysis" steps that are often necessary to prepare summary data reported in epidemiologic studies for dose-response analysis." | ( Systematic dose-response of environmental epidemiologic studies: Dose and response pre-analysis. Allen, B; Cote, I; Davis, JA; Druwe, I; Gift, J; Hobbie, K; Lee, JS; Mendez, W; Shao, K, 2020) | 0.56 |
| "This paper describes the use of multiple models and model averaging for considering dose-response uncertainties when extrapolating low-dose risk from studies of populations with high levels of exposure." | ( Model averaging methods for the evaluation of dose-response model uncertainty when assessing the suitability of studies for estimating risk. Cote, I; Davis, A; Druwe, IL; Gift, JS; Lee, JS; Mendez, W; Shao, K, 2020) | 0.56 |
| " Using multivariable models, a dose-response relationship was observed between BNP concentrations and UAs tertiles (<47 ng/mL: reference, 47-72 ng/mL: 48." | ( Natriuretic peptides and echocardiographic parameters in Mexican children environmentally exposed to arsenic. Aguilar-Madrid, G; Arreola-Mendoza, L; Ayllon-Vergara, JC; Del Razo, LM; Osorio-Yáñez, C; Sánchez-Peña, LC; Torres-Arellano, JM, 2020) | 0.56 |
| "There are unique challenges in estimating dose-response with chemicals that are associated with multiple health outcomes and numerous studies." | ( Use of study-specific MOE-like estimates to prioritize health effects from chemical exposure for analysis in human health assessments. Cote, I; Davis, JA; Druwe, IL; Gift, JS; Henning, C; Hobbie, K; Lee, JS; Mendez, W; Shao, K, 2020) | 0.56 |
| "When assessing the human risks due to exposure to environmental chemicals, traditional dose-response analyses are not straightforward when there are numerous high-quality epidemiological studies of priority cancer and non-cancer health outcomes." | ( Bayesian hierarchical dose-response meta-analysis of epidemiological studies: Modeling and target population prediction methods. Allen, B; Cote, I; Davis, JA; Druwe, I; Gift, JS; Hobbie, K; Lee, JS; Mendez, W; Shao, K, 2020) | 0.56 |
| " To remove As to below the WHO guideline of 10 µg/L, 10 times lower charge dosage was required for the bio-FeEC system compared to conventional FeEC." | ( Integrating biological As(III) oxidation with Fe(0) electrocoagulation for arsenic removal from groundwater. Rietveld, L; Roy, M; van Genuchten, CM; van Halem, D, 2021) | 0.62 |
| " The most cadmium is consumed with smoked mackerel from the North Sea, comprising as much as 162% of the daily acceptable dosage ." | ( Content of toxic metals and As in marine and freshwater fish species available for sale in EU supermarkets and health risk associated with its consumption. Adamiec, E; Jarosz-Krzemińska, E; Mikołajczyk, N, 2021) | 0.62 |
| " We observed a non-linear dose-response of Se and reduced BMD, showing an inverse association below ~105 μg/L, which became increasingly positive above ~105 μg/L." | ( Arsenic, cadmium, and selenium exposures and bone mineral density-related endpoints: The HORTEGA study. Briongos-Figuero, LS; Dueñas-Laita, A; Galan-Labaca, I; Galvez-Fernandez, M; Garcia-Barrera, T; Gomez-Ariza, JL; Grau-Perez, M; Martin-Escudero, JC; Navas-Acien, A; Perez-Castrillon, JL; Perez-Gomez, B; Ramirez-Acosta, S; Redon, J; Tellez-Plaza, M, 2021) | 0.62 |
| " Different parameters like heating temperatures, heat duration, stabilizer type and dosage were optimized for effective removal of TCs and ROX." | ( Study on the remediation of tetracycline antibiotics and roxarsone contaminated soil. Xia, Z; Xie, B; Xu, Z; Zhan, L, 2021) | 0.62 |
| " The effect on DA level changed slowly after DPAA administration, with a bell-shaped dose-response relationship." | ( Toxicokinetic characteristics and effects of diphenylarsinic acid on dopamine in the striatum of free-moving mice. Shibata, Y; Umezu, T, 2021) | 0.62 |
| " The toxicokinetics of PENAO has been investigated in Sprague-Dawley rats to inform route of administration and dosing for human clinical trials." | ( Toxicokinetics of the tumour cell mitochondrial toxin, PENAO, in rodents. Hogg, PJ, 2021) | 0.62 |
| " This paper reports that hormetic-biphasic dose-response relationships were commonly observed for multiple agents (i." | ( Accumulator plants and hormesis. Agathokleous, E; Calabrese, EJ, 2021) | 0.62 |
| " To accomplish this, the lethality assay was done, and based on the results, the dosage for As (1 mM) and FA (30 μM) was fixed." | ( Mitigation of arsenic induced developmental cardiotoxicity by ferulic acid in zebrafish. Balasubramanian, S; Eswaran, S; Parvin, R; Perumal, E, 2021) | 0.62 |
| " Dose-response assessment results obtained from a number of alternative model structures and methods consistently demonstrate a threshold type dose-response curve with a threshold in the range between 40-60 μg/L of iAs concentration in drinking water." | ( Bayesian benchmark dose analysis for inorganic arsenic in drinking water associated with bladder and lung cancer using epidemiological data. Cohen, SM; Shao, K; Xun, P; Zhou, Z, 2021) | 0.62 |
| " The human health risk related to Mn contamination was estimated by computing the average daily dosage (ADD) and hazard quotient (HQ) values for children and adults." | ( Spatial distribution of manganese in groundwater and associated human health risk in the southern part of the Bengal Basin. Ahmed, KM; Mustafa, MG; Rahman, M; Siddique, MAM; Tushar, MAN; Zahid, A, 2021) | 0.62 |
| " While previous epidemiology studies have demonstrated increased risks of bladder, lung, and skin cancers at arsenic exposures of 200 ug/L or greater, we seek here to examine the dose-response patterns at lower exposure levels." | ( A review of low-dose arsenic risks and human cancers. Ahn, J; Boroje, IJ; Ferdosi, H; Lamm, SH, 2021) | 0.62 |
| " Furthermore, preliminary meta-analyses of epidemiology dose-response data for inorganic arsenic (iAs) and bladder cancer, correlated to dose-response data measured in vitro, support a threshold of effect in humans on the order of 50-100 μg/L in drinking water." | ( Historical perspective on the role of cell proliferation in carcinogenesis for DNA-reactive and non-DNA-reactive carcinogens: Arsenic as an example. Beck, BD; Cohen, JM; Rhomberg, LR, 2021) | 0.62 |
| "Scientifically robust selections of epidemiological studies and assessments of the dose-response of inorganic arsenic in the low-dose range must consider key issues specific to arsenic in order to reduce risk of bias." | ( Essential concepts for interpreting the dose-response of low-level arsenic exposure in epidemiological studies. Chang, ET; Lennox, KP; Tsuji, JS; Watson, HN, 2021) | 0.62 |
| " These applications illustrate the broad utility of PBTK models for exposure and dose-response analysis, particularly for arsenic where multi-pathway, multi-route exposures and multiple toxic effects are of concern." | ( Arsenic toxicokinetic modeling and risk analysis: Progress, needs and applications. Kenyon, EM, 2021) | 0.62 |
| "While the dose-response relationship for the carcinogenic effects of arsenic exposure indicates nonlinearity with increases only above about 150 μg/L arsenic in drinking water, similar analyses of noncarcinogenic effects of arsenic exposure remain to be conducted." | ( Aortic Elasticity and Arsenic Exposure: A Step Function rather than a Linear Function. Ahn, J; Boroje, IJ; Ferdosi, H; Lamm, SH, 2021) | 0.62 |
| " We estimated multivariable adjusted hazard ratios (HRs) for heart disease mortality per interquartile range (IQR) increase in urinary arsenic levels using survey-weighted, Cox proportional hazards models, and evaluated flexible dose-response analyses using restricted quadratic spline models." | ( Urinary arsenic and heart disease mortality in NHANES 2003-2014. Jones, MR; Moon, KA; Navas-Acien, A; Nigra, AE; Sanchez, TR, 2021) | 0.62 |
| "Despite a small number of events, relatively short follow-up time, and high analytical limits of detection for urinary arsenic species, iAs exposure at low-to moderate-levels is consistent with increased heart disease mortality in NHANES 2003-2014 although the associations were only significant in flexible dose-response models." | ( Urinary arsenic and heart disease mortality in NHANES 2003-2014. Jones, MR; Moon, KA; Navas-Acien, A; Nigra, AE; Sanchez, TR, 2021) | 0.62 |
| " ATO is dosed on actual body weight and high ATO doses in overweight patients may contribute to increased toxicity." | ( Arsenic trioxide dose capping to decrease toxicity in the treatment of acute promyelocytic leukemia. Baer, MR; DeZern, A; Duong, VH; Emadi, A; Gehrie, E; Ghiaur, G; Gojo, I; Hambley, B; Hickey, E; Kashanian, S; Levis, MJ; Li, A; Newman, MJ; Smith, BD; Varadhan, R; Zacholski, K, 2022) | 0.72 |
| " A two-piece-wise regression model was used to assess the dose-response relationship between heavy metal exposure and nephrolithiasis." | ( Analysis of Threshold Effect of Urinary Heavy Metal Elements on the High Prevalence of Nephrolithiasis in Men. Hong, F; Lei, J; Liu, Y; Qin, Z; Tang, X; Wang, Q; Yang, Q; Zhang, C, 2022) | 0.72 |
| " We also examined the dose-response relationship to provide a theoretical basis for precision interventions in the population by conducting a two-stage random-effects dose-response meta-analysis." | ( The association of arsenic exposure with hypertension and blood pressure: A systematic review and dose-response meta-analysis. Li, A; Li, K; Li, Y; Mei, Y; Xu, Q; Zhao, J; Zhou, Q, 2021) | 0.62 |
| " Furthermore, Faecalibaculum, Lachnospiraceae_NK4A136_group, Angelakisella, Ruminiclostridium, and Desulfovibrionaceae are positively associated with arsenic dosage and may be useful in the early detection of arsenicals." | ( Sub-chronic low-dose arsenic in rice exposure induces gut microbiome perturbations in mice. Chen, F; Chen, L; Guo, L; Guo, X; Li, C; Luo, Y; Wang, J; Zhang, B; Zhong, X; Zhou, Y; Zhu, Q; Zou, R, 2021) | 0.62 |
| " A pot experiment with different levels of sulfate dosage (0, 20, 40, 60 and 80 mg/kg) was set up in this study to explore the influence of sulfate fertilizer on rice plant growth, yield, and As accumulation in rice grain." | ( Effect of sulfate application on inhibition of arsenic bioaccumulation in rice (Oryza sativa L.) with consequent health risk assessment of cooked rice arsenic on human: A pot to plate study. Acharya, K; Chowdhury, NR; Das, A; De, A; Joardar, M; Mridha, D; Ray, I; Roychowdhury, T; Sarkar, J, 2022) | 0.72 |
| " Pregnant Sprague-Dawley (SD) rats were exposed to arsenite (AsIII) via oral gavage on gestational days (GD) 6 through 21, and pups were directly dosed via gavage on postnatal days (PND) 1 through 21." | ( Neurobehavioral and neurochemical effects of perinatal arsenite exposure in Sprague-Dawley rats. Cuevas-Martinez, E; Ferguson, SA; Fitzpatrick, S; Flanigan, TJ; Law, CD; Rosas-Hernandez, H; Shen, AN, ) | 0.13 |
| " With regard to the single exposure level, the lnTAs showed positive correlations with ln%DMA, lnPMI, and lnSMI when lniAs was set at a specific level, while lniAs showed negative correlations with ln%DMA, lnPMI, and lnSMI when lnTAs was set at a specific level; all the dose-response relationships were nonlinear." | ( Influence of combined exposure levels of total arsenic and inorganic arsenic on arsenic methylation capacity among university students: findings from Bayesian kernel machine regression analysis. He, S; Hu, Y; Ji, D; Jiang, R; Jiang, T; Liang, C; Ma, Y; Shen, J; Song, Y; Tao, F; Tao, L; Tong, S; Yao, Y; Zhang, Q; Zhang, W, 2022) | 0.72 |
| " lobata (Kudzu) Extract, and RM 8652 Kudzu-Containing Solid Oral Dosage Form were issued with values assigned for isoflavones (puerarin, daidzin, and daidzein), toxic elements (arsenic, cadmium, and lead), and selenium." | ( Development of Kudzu (Pueraria Montana var. lobata) Reference Materials for the Determination of Isoflavones and Toxic Elements. Barber, CA; Bryan, CE; Kuszak, AJ; Lippert, JA; Long, SE; Nelson, MA; Phillips, MM; Rimmer, CA; Sharpless, KE; Wise, SA; Wood, LJ; Yen, J, 2022) | 0.72 |
| " The population attributable fraction was calculated based on the dose-response relationship between iAs and CHD risk." | ( Burden of Coronary Heart Disease and Cancer from Dietary Exposure to Inorganic Arsenic in Adults in China, 2016. Cui, Y; Huang, J; Li, Y; Liu, J; Song, W; Wang, Q; Wang, Y; Wei, S, 2022) | 0.72 |
| " We also observed significant dose-response relationships of pollutant mixtures with reduced eGFR levels and increased odds of CKD in BKMR models." | ( Co-exposure to perfluoroalkyl acids and heavy metals mixtures associated with impaired kidney function in adults: A community-based population study in China. Dong, GH; Feng, WR; Huang, WZ; Lv, JY; Ou, YQ; Su, F; Tang, XJ; Wu, Y; Xiong, LH; Zeeshan, M; Zeng, XW; Zhou, Y, 2022) | 0.72 |
| "The major goal of this study was to estimate the correlations and dose-response pattern between the measured blood toxic metals (cadmium (Cd), mercury (Hg), chromium (Cr), nickel (Ni))/metalloid (arsenic (As)) and serum insulin level by conducting Benchmark dose (BMD) analysis of human data." | ( Exploring the relationship between blood toxic metal(oid)s and serum insulin levels through benchmark modelling of human data: Possible role of arsenic as a metabolic disruptor. Antonijević, B; Baralić, K; Buha Djordjevic, A; Bulat, Z; Ćurčić, M; Javorac, D; Repić, A; Đorđević, V; Đukić-Ćosić, D, 2022) | 0.72 |
| " We used general linear models and restricted cubic splines to test dose-response relationships between single metals and fetal growth." | ( Maternal exposure to metal mixtures during early pregnancy and fetal growth in the Jiangsu Birth Cohort, China. Dou, Y; Du, J; Guo, W; Hu, Z; Jiang, T; Jiang, Y; Jin, G; Li, M; Li, Z; Lin, Y; Lu, C; Lu, Q; Lv, H; Ma, H; Qin, R; Qiu, Y; Yin, Y, 2022) | 0.72 |
| " Besides, restricted cubic spline analysis verified the relationship between molybdenum level and increased MRI risk in a linear and dose-response manner." | ( Associations between plasma metal levels and mild renal impairment in the general population of Southern China. Fu, X; Huang, H; Huang, S; Liu, R; Liu, Y; Lu, Q; Lv, Z; Wang, T; Wen, Y; Yang, Z; Zhang, Y; Zheng, S; Zou, X, 2022) | 0.72 |
| " The effects of major operating variables such as coagulant dosing (50, 125 and 200 mg/L), co-coagulant dosing (5, 12." | ( Optimization of Coagulation-Flocculation Process in Efficient Arsenic Removal from Highly Contaminated Groundwater by Response Surface Methodology. Amiri, S; He, T; Vatanpour, V, 2022) | 0.72 |
| " Moreover, the toxic metal mixture (As, Cd, and Pb) exhibited a significant negative association with MMSE scores in a dose-response pattern, with Pb being the greatest contributor within the mixture." | ( Selenium attenuates the association of co-exposure to arsenic, cadmium, and lead with cognitive function among Chinese community-dwelling older adults. Cao, HJ; Chen, GM; Cheng, BJ; Li, XD; Meng, XL; Nie, HH; Sheng, J; Tao, FB; Wang, HL; Wang, SF; Wang, Y; Yang, LS; Zhang, DM; Zhou, TT, 2023) | 0.91 |
| " The present review suggested that different age groups may respond differently to arsenic exposure, and the dose-response effect of arsenic could be a critical factor in its effect on telomere length." | ( Telomeres susceptibility to environmental arsenic exposure: Shortening or lengthening? Aisyah, CR; Hninn, TSS; Myar, MT; Swe, T; Wai, KM, 2022) | 0.72 |
| " Here, we evaluate dosage dependency of iAs metabolism in humanized (Hs) mice." | ( Fate of arsenicals in mice carrying the human AS3MT gene exposed to environmentally relevant levels of arsenite in drinking water. Cable, PH; Douillet, C; El-Masri, H; Koller, BH; Matoušek, T; Miller, M; Shi, Q; Stýblo, M; Thomas, DJ, 2023) | 0.91 |
| " However, depending on the type of toxic metal and the carrier system used to release TQ in biological systems, its therapeutic dosage range may be varied." | ( Protective potential of thymoquinone against cadmium, arsenic, and lead toxicity: A short review with emphasis on oxidative pathways. Ghasemi, F; Nili-Ahmadabadi, A; Nili-Ahmadabadi, M; Omidifar, N, 2023) | 0.91 |
| " In the present study, the median effect plot and the combination index isobologram were studied to evaluate the dose-response curve for individual and interactive impacts of chlorpyrifos (Chl), cypermethrin (Cyp), and arsenic (As) on soil dehydrogenase, a potential marker of soil health." | ( Effect of toxicological interaction of chlorpyrifos, cypermethrin, and arsenic on soil dehydrogenase activity in the terrestrial environment. Kumar, A; Nistala, S, 2023) | 0.91 |
| " After 28-day exposure, the strongest dose-response relationship was found between hormones: LH and FSH and toxic metal(oid)s and, after 90-day exposure, between investigated redox status parameters: sulfhydryl groups, ischemia-modified albumin and nuclear factor erythroid 2-related factor 2 (Nrf2) and toxic metal(oid)s." | ( Effects of the real-life metal(oid)s mixture on female reproductive function: Less is different. Antonijević Miljaković, E; Antonijević, B; Anđelković, M; Baralić, K; Buha Djordjevic, A; Bulat, Z; Marić, Đ; Vukelić, D; Đukić-Ćosić, D, 2023) | 0.91 |
| " Survey-weighted logistic regression and restricted cubic spline (RCS) analyses were performed to determine the association and dose-response relationship between UTAs and IR or diabetes risk." | ( Additive interaction of urinary total arsenic concentrations with being overweight/obesity on the risk of insulin resistance: NHANES 2007-2016. Gong, Y; Li, Y; Ma, Y; Wu, Y; Zhang, X; Zhi, X, 2023) | 0.91 |
| " This systematic review and dose-response meta-analysis aim to update information on the association between arsenic exposure and the risk of T2DM." | ( An updated systematic review and dose-response meta-analysis on the relation between exposure to arsenic and risk of type 2 diabetes. Abdollahi, M; Asadi, T; Esmaeili, M; Habibian Sezavar, A; Moradi, A; Mousavi, T; Nikfar, S; Rahimi Kakavandi, N, 2023) | 0.91 |
| " In this study, we conducted a 22-year follow-up investigation to assess the risk of skin lesions and cancer resulting from long-term, multi-channel arsenic exposure from hazard identification, dose-response assessment, exposure assessment, and risk characterization." | ( Assessing the health risks of coal-burning arsenic-induced skin damage: A 22-year follow-up study in Guizhou, China. Li, J; Liang, B; Luo, P; Sun, B; Yang, G; Yao, M; Zeng, Q; Zhang, A, 2023) | 0.91 |
| " The results of this study could form the basis for more detailed investigations under controlled conditions, including plant dosing experiments." | ( Thallium hyperaccumulation status of the violets of the Allchar arsenic-thallium deposit (North Macedonia) confirmed through synchrotron µXRF imaging. Bačeva Andonovska, K; Baker, AJM; Brueckner, D; Echevarria, G; Jakovljević, K; Mišljenović, T; van der Ent, A, 2023) | 0.91 |
| " Moreover, we observed significant dose-response relationship between MMA% and 8-hydroxy-2-deoxyguanosine (8-OHdG)." | ( Association of urinary arsenic metabolism with type 2 diabetes and glucose homeostasis: Cross-sectional and longitudinal associations. He, M; Li, W; Li, Z; Wang, R; Yan, Y; Zhang, J; Zhou, Q, 2023) | 0.91 |
| " Multiple linear models and restricted cubic splines were used to evaluate dose-response relationships between single metal and children's physical and behavioral development." | ( Exposure to metal mixtures and young children's growth and development: A biomonitoring-based study in Eastern China. Geng, S; Han, L; Ma, J; Sun, Q; Wen, J; Yao, X; Zhang, B; Zhang, X; Zhu, L, 2023) | 0.91 |
| Role | Description |
|---|---|
| micronutrient | Any nutrient required in small quantities by organisms throughout their life in order to orchestrate a range of physiological functions. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| pnictogen | Any p-block element atom that is in group 15 of the periodic table: nitrogen, phosphorus, arsenic, antimony and bismuth. |
| metalloid atom | An atom of an element that exhibits properties that are between those of metals and nonmetals, or that has a mixture of them. The term generally includes boron, silicon, germanium, arsenic, antimony, and tellurium, while carbon, aluminium, selenium, polonium, and astatine are less commonly included. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Pathway | Proteins | Compounds |
|---|---|---|
| Arsenic metabolism and reactive oxygen species generation | 0 | 10 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1079943 | Malignant tumor, proven histopathologically. Value is number of references indexed. [column 'T.MAL' in source] | |||
| AID678929 | TP_TRANSPORTER: increase in liver concentration in mdr1a/1b(-/-) mouse | 2002 | Toxicology, Jan-15, Volume: 170, Issue:1-2 | Multidrug-resistance mdr1a/1b double knockout mice are more sensitive than wild type mice to acute arsenic toxicity, with higher arsenic accumulation in tissues. |
| AID1079937 | Severe hepatitis, defined as possibly life-threatening liver failure or through clinical observations. Value is number of references indexed. [column 'MASS' in source] | |||
| AID1079942 | Steatosis, proven histopathologically. Value is number of references indexed. [column 'STEAT' in source] | |||
| AID1079938 | Chronic liver disease either proven histopathologically, or through a chonic elevation of serum amino-transferase activity after 6 months. Value is number of references indexed. [column 'CHRON' in source] | |||
| AID1079935 | Cytolytic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is > 5 (see ACUTE). Value is number of references indexed. [column 'CYTOL' in source] | |||
| AID1079936 | Choleostatic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is < 2 (see ACUTE). Value is number of references indexed. [column 'CHOLE' in source] | |||
| AID1079941 | Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive disease, Budd-Chiari syndrome. Value is number of references indexed. [column 'VASC' in source] | |||
| AID1079944 | Benign tumor, proven histopathologically. Value is number of references indexed. [column 'T.BEN' in source] | |||
| AID678930 | TP_TRANSPORTER: increase in kidney concentration in mdr1a/1b(-/-) mouse | 2002 | Toxicology, Jan-15, Volume: 170, Issue:1-2 | Multidrug-resistance mdr1a/1b double knockout mice are more sensitive than wild type mice to acute arsenic toxicity, with higher arsenic accumulation in tissues. |
| AID1079947 | Comments (NB not yet translated). [column 'COMMENTAIRES' in source] | |||
| AID1079933 | Acute liver toxicity defined via clinical observations and clear clinical-chemistry results: serum ALT or AST activity > 6 N or serum alkaline phosphatases activity > 1.7 N. This category includes cytolytic, choleostatic and mixed liver toxicity. Value is | |||
| AID1079948 | Times to onset, minimal and maximal, observed in the indexed observations. [column 'DELAI' in source] | |||
| AID1079934 | Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source] | |||
| AID678931 | TP_TRANSPORTER: increase in intestine concentration in mdr1a/1b(-/-) mouse | 2002 | Toxicology, Jan-15, Volume: 170, Issue:1-2 | Multidrug-resistance mdr1a/1b double knockout mice are more sensitive than wild type mice to acute arsenic toxicity, with higher arsenic accumulation in tissues. |
| AID1079940 | Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source] | |||
| AID1079949 | Proposed mechanism(s) of liver damage. [column 'MEC' in source] | |||
| AID1079946 | Presence of at least one case with successful reintroduction. [column 'REINT' in source] | |||
| AID1079932 | Highest frequency of moderate liver toxicity observed during clinical trials, expressed as a percentage. [column '% BIOL' in source] | |||
| AID1079931 | Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum activity 6 times the normal upper limit (N) or alkaline phosphatase serum activity of 1.7 N. Value is number of references indexed. [column 'BIOL' in source] | |||
| AID1079939 | Cirrhosis, proven histopathologically. Value is number of references indexed. [column 'CIRRH' in source] | |||
| AID1079945 | Animal toxicity known. [column 'TOXIC' in source] | |||
| AID682032 | TP_TRANSPORTER: increase in brain concentration in mdr1a/1b(-/-) mouse | 2002 | Toxicology, Jan-15, Volume: 170, Issue:1-2 | Multidrug-resistance mdr1a/1b double knockout mice are more sensitive than wild type mice to acute arsenic toxicity, with higher arsenic accumulation in tissues. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 5240 (19.67) | 18.7374 |
| 1990's | 1468 (5.51) | 18.2507 |
| 2000's | 6025 (22.61) | 29.6817 |
| 2010's | 9817 (36.85) | 24.3611 |
| 2020's | 4093 (15.36) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 280 (1.01%) | 5.53% |
| Reviews | 1,841 (6.62%) | 6.00% |
| Case Studies | 538 (1.93%) | 4.05% |
| Observational | 14 (0.05%) | 0.25% |
| Other | 25,133 (90.39%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||