Compounds > 3-amino-1-4-dimethyl-5h-pyrido(4-3-b)indole

3-amino-1-4-dimethyl-5h-pyrido(4-3-b)indole and Necrosis

3-amino-1-4-dimethyl-5h-pyrido(4-3-b)indole has been researched along with Necrosis* in 1 studies

Other Studies

1 other study(ies) available for 3-amino-1-4-dimethyl-5h-pyrido(4-3-b)indole and Necrosis

Article	Year
3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole induces apoptosis and necrosis with activation of different caspases in rat splenocytes. Bioscience, biotechnology, and biochemistry, 2004, Volume: 68, Issue:4 A dietary carcinogen, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) at 20 microM activates caspase-3-like proteases as an apoptotic marker in rat splenocytes. The present study demonstrated 100 microM Trp-P-1 induced necrosis with activation of caspase-3-like proteases. The activation in necrosis and apoptosis resulted from the activation of caspase-9 and caspase-8, respectively. Thus, Trp-P-1 induces apoptosis and necrosis with the activation of different caspases. Topics: Animals; Apoptosis; Carbolines; Caspases; Enzyme Activation; Necrosis; Rats; Reactive Oxygen Species; Spleen	2004

Article

Year

3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole induces apoptosis and necrosis with activation of different caspases in rat splenocytes.

Bioscience, biotechnology, and biochemistry, 2004, Volume: 68, Issue:4

A dietary carcinogen, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) at 20 microM activates caspase-3-like proteases as an apoptotic marker in rat splenocytes. The present study demonstrated 100 microM Trp-P-1 induced necrosis with activation of caspase-3-like proteases. The activation in necrosis and apoptosis resulted from the activation of caspase-9 and caspase-8, respectively. Thus, Trp-P-1 induces apoptosis and necrosis with the activation of different caspases.

Topics: Animals; Apoptosis; Carbolines; Caspases; Enzyme Activation; Necrosis; Rats; Reactive Oxygen Species; Spleen

2004