A carnitine O-palmitoyltransferase 1, muscle isoform that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92523]
CPT1-M;
EC 2.3.1.21;
Carnitine O-palmitoyltransferase I, muscle isoform;
CPT I;
CPTI-M;
Carnitine palmitoyltransferase 1B;
Carnitine palmitoyltransferase I-like protein
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 4-hydroxyphenylglyoxylic acid | Homo sapiens (human) | IC50 | 35.6500 | 2 | 2 |
| amiodarone | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| perhexiline | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| cordycepin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 0 |
| trimetazidine | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 4-hydroxyphenylglycine, (s)-isomer | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| tebuconazole | Homo sapiens (human) | IC50 | 0.1259 | 1 | 0 |
| corydaline | Homo sapiens (human) | IC50 | 79.4328 | 1 | 0 |
| emeriamine | Homo sapiens (human) | IC50 | 63.6500 | 2 | 2 |
| N-(1,3-benzodioxol-5-yl)-2-[[3-(2-methoxyphenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]thio]acetamide | Homo sapiens (human) | IC50 | 63.0957 | 1 | 0 |
| 2-(1,3-benzodioxol-5-yl)-5-[[2-(4-methoxyphenyl)-4,5-dihydrothiazol-5-yl]methylthio]-1,3,4-oxadiazole | Homo sapiens (human) | IC50 | 10.0000 | 1 | 0 |
| 4-trimethylammonio-3-((tetradecylcarbamoyl)amino)butyrate | Homo sapiens (human) | IC50 | 3.4250 | 2 | 2 |
| formycin b | Homo sapiens (human) | IC50 | 100.0000 | 1 | 0 |
This protein enables 2 target(s):
| Target | Category | Definition |
|---|---|---|
| carnitine O-palmitoyltransferase activity | molecular function | Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine. [EC:2.3.1.21] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| mitochondrial outer membrane | cellular component | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. [GOC:ai] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| fatty acid metabolic process | biological process | The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198547684] |
| fatty acid beta-oxidation | biological process | A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY] |
| carnitine shuttle | biological process | The transfer of acyl groups to and from acyl-CoA molecules to form O-acylcarnitine, which can exchange across the mitochondrial inner membrane with unacylated carnitine. [ISBN:0198547684] |
| carnitine metabolic process | biological process | The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. [GOC:jl, ISBN:0198506732] |
| response to blue light | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. [GOC:ai, GOC:mtg_far_red] |
| long-chain fatty acid transport | biological process | The directed movement of a long-chain fatty acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [GOC:ai] |