Compounds > dibenzylchlorethamine
Page last updated: 2024-09-20

dibenzylchlorethamine

Description

Dibenzylchlorethamine: An alpha adrenergic antagonist. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5820
CHEMBL ID3305685
SCHEMBL ID479112
MeSH IDM0454899

Synonyms (46)

Synonym
AA-516/31407024
n,n-dibenzyl-n-(2-chloroethyl)amine
dibenzyl-2-chloroethylamine
2-chloroethyldibenzylamine
n,n-dibenzyl-beta-chloroethylamine
dibenzyl chlorethylamine
dibenzyl(2-chloroethyl)amine
skf 199
n-(2-chloroethyl)dibenzylamine
dibenzylchlorethamine
dibenzylamine, n-(2-chloroethyl)-
2-(dibenzylamino)ethyl chloride
hsdb 2086
n,n-dibenzyl-2-chloroethylamine
dibenamine
benzenemethanamine, n-(2-chloroethyl)-n-(phenylmethyl)-
brn 2213696
dibenzylchlorethylamine
PDSP2_001084
PDSP1_001100
n,n-dibenzyl-2-chloroethanamine
bdbm81445
nsc_5820
cas_55-43-6
AKOS005459848
51-50-3
unii-43exu2s56h
43exu2s56h ,
4-12-00-02180 (beilstein handbook reference)
STK526670
BBL028457
1-dibenzylamino-2-chloroethane
dibenzyl-(2-chloro-ethyl)-amine
dibenamine [mi]
n,n-dibenzyl-.beta.-chloroethylamine
n,n-dibenzylaminoethyl chloride
n-(2-chloroethyl)-n-(phenylmethyl)benzenemethanamine
dibenamine [hsdb]
SCHEMBL479112
CHEMBL3305685
n,n-dibenzyl-2-chloroethanamine #
DTXSID20199001
sr-01000883996
SR-01000883996-1
2-chloro-n,n-bis(phenylmethyl)ethanamine
Q27258645

Research

Studies (570)

TimeframeStudies, This Drug (%)All Drugs %
pre-1990556 (97.54)18.7374
1990's12 (2.11)18.2507
2000's2 (0.35)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews7 (1.15%)6.00%
Case Studies2 (0.33%)4.05%
Observational0 (0.00%)0.25%
Other600 (98.52%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
cyclopropane[no description available]medium80cycloalkane;
cyclopropanes		inhalation anaesthetic
2-chloroethylamine[no description available]medium70
pituitrin[no description available]medium90
tolazoline[no description available]medium290imidazolesalpha-adrenergic antagonist;
antihypertensive agent;
vasodilator agent
papaverine[no description available]medium210benzylisoquinoline alkaloid;
dimethoxybenzene;
isoquinolines		antispasmodic drug;
vasodilator agent
nitroglycerin[no description available]medium20nitroglycerolexplosive;
muscle relaxant;
nitric oxide donor;
prodrug;
tocolytic agent;
vasodilator agent;
xenobiotic
glycerol[no description available]medium20alditol;
triol		algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent
nitrites[no description available]medium30monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species		human metabolite
nitrates[no description available]medium20monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species
prazosin[no description available]medium60aromatic ether;
furans;
monocarboxylic acid amide;
piperazines;
quinazolines		alpha-adrenergic antagonist;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
phenoxybenzamine[no description available]medium850aromatic amine
oxymetazoline[no description available]medium50carboxamidine;
imidazolines;
phenols		alpha-adrenergic agonist;
nasal decongestant;
sympathomimetic agent;
vasoconstrictor agent
cirazoline[no description available]medium10aromatic ether
szl 49[no description available]medium20
a 61603[no description available]medium10tetralins
atropine[no description available]medium850
methantheline[no description available]medium20xanthenes
sodium salicylate[no description available]medium40organic molecular entity
salicylates[no description available]medium10monohydroxybenzoateplant metabolite
iodine[no description available]medium60diatomic iodinenutrient
thiouracil[no description available]medium20nucleobase analogue;
thiocarbonyl compound		antithyroid drug;
metabolite
choline[no description available]medium80cholinesallergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter;
nutrient;
plant metabolite;
Saccharomyces cerevisiae metabolite
dibenzylamine[no description available]medium20aromatic amine
cortisone[no description available]medium3011-oxo steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		human metabolite;
mouse metabolite
mescaline[no description available]medium20methoxybenzenes;
phenethylamine alkaloid;
primary amino compound		hallucinogen
mechlorethamine[no description available]medium20nitrogen mustard;
organochlorine compound		alkylating agent
glucagon[no description available]medium20peptide hormone
acetazolamide[no description available]medium20monocarboxylic acid amide;
sulfonamide;
thiadiazoles		anticonvulsant;
diuretic;
EC 4.2.1.1 (carbonic anhydrase) inhibitor
chlorpromazine[no description available]medium320organochlorine compound;
phenothiazines;
tertiary amine		anticoronaviral agent;
antiemetic;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
phenothiazine antipsychotic drug
tripelennamine[no description available]medium20aromatic amine
ephedrine[no description available]medium60phenethylamine alkaloid;
phenylethanolamines		bacterial metabolite;
environmental contaminant;
nasal decongestant;
plant metabolite;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic
phentolamine[no description available]medium820imidazoles;
phenols;
substituted aniline;
tertiary amino compound		alpha-adrenergic antagonist;
vasodilator agent
hydralazine[no description available]medium50azaarene;
hydrazines;
ortho-fused heteroarene;
phthalazines		antihypertensive agent;
vasodilator agent
hydrogen carbonate[no description available]medium20carbon oxoanioncofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
triethylammonium bicarbonate[no description available]medium10
reserpine[no description available]medium640alkaloid ester;
methyl ester;
yohimban alkaloid		adrenergic uptake inhibitor;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
first generation antipsychotic;
plant metabolite;
xenobiotic
arginine vasopressin[no description available]medium10vasopressincardiovascular drug;
hematologic agent;
mitogen
piperoxan[no description available]medium20
pentobarbital[no description available]medium70barbituratesGABAA receptor agonist
2-naphthylamine[no description available]medium10naphthylaminecarcinogenic agent
iproniazid[no description available]medium80carbohydrazide;
pyridines
ergotamine[no description available]medium280peptide ergot alkaloidalpha-adrenergic agonist;
mycotoxin;
non-narcotic analgesic;
oxytocic;
serotonergic agonist;
vasoconstrictor agent
phlorhizin[no description available]medium10aryl beta-D-glucoside;
dihydrochalcones;
monosaccharide derivative		antioxidant;
plant metabolite
yohimbine[no description available]medium200methyl 17-hydroxy-20xi-yohimban-16-carboxylatealpha-adrenergic antagonist;
dopamine receptor D2 antagonist;
serotonergic antagonist
physostigmine[no description available]medium180carbamate ester;
indole alkaloid		antidote to curare poisoning;
EC 3.1.1.8 (cholinesterase) inhibitor;
miotic
phenothiazine[no description available]medium10phenothiazineferroptosis inhibitor;
plant metabolite;
radical scavenger
prenylamine[no description available]medium30diarylmethane
dipyridamole[no description available]medium30piperidines;
pyrimidopyrimidine;
tertiary amino compound;
tetrol		adenosine phosphodiesterase inhibitor;
EC 3.5.4.4 (adenosine deaminase) inhibitor;
platelet aggregation inhibitor;
vasodilator agent
khellin[no description available]medium10furanochromone;
organic heterotricyclic compound;
oxacycle		anti-asthmatic agent;
bronchodilator agent;
cardiovascular drug;
vasodilator agent
guanethidine[no description available]medium220azocanes;
guanidines		adrenergic antagonist;
antihypertensive agent;
sympatholytic agent
procaine[no description available]medium50benzoate ester;
substituted aniline;
tertiary amino compound		central nervous system depressant;
drug allergen;
local anaesthetic;
peripheral nervous system drug
carbachol[no description available]medium210ammonium salt;
carbamate ester		cardiotonic drug;
miotic;
muscarinic agonist;
nicotinic acetylcholine receptor agonist;
non-narcotic analgesic
4-aminobenzoic acid[no description available]medium10aminobenzoic acid;
aromatic amino-acid zwitterion		allergen;
Escherichia coli metabolite;
plant metabolite
histamine[no description available]medium350aralkylamino compound;
imidazoles		human metabolite;
mouse metabolite;
neurotransmitter
isoproterenol[no description available]medium1000catechols;
secondary alcohol;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
sympathomimetic agent
pheniprazine[no description available]medium10amphetamines
hydrazine[no description available]medium50azane;
hydrazines		EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
methylphenidate[no description available]medium20beta-amino acid ester;
methyl ester;
piperidines
amphetamine[no description available]medium80primary amine
cocaine[no description available]medium360benzoate ester;
methyl ester;
tertiary amino compound;
tropane alkaloid		adrenergic uptake inhibitor;
central nervous system stimulant;
dopamine uptake inhibitor;
environmental contaminant;
local anaesthetic;
mouse metabolite;
plant metabolite;
serotonin uptake inhibitor;
sodium channel blocker;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic
dichloroisoproterenol[no description available]medium20
phenylephrine[no description available]medium420phenols;
phenylethanolamines;
secondary amino compound		alpha-adrenergic agonist;
cardiotonic drug;
mydriatic agent;
nasal decongestant;
protective agent;
sympathomimetic agent;
vasoconstrictor agent
triflupromazine[no description available]medium10organofluorine compound;
phenothiazines;
tertiary amine		anticoronaviral agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic
thioridazine[no description available]medium20phenothiazines;
piperidines		alpha-adrenergic antagonist;
dopaminergic antagonist;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
first generation antipsychotic;
H1-receptor antagonist;
serotonergic antagonist
chloralose[no description available]medium10
urethane[no description available]medium30carbamate esterfungal metabolite;
mutagen
hexobarbital[no description available]medium10barbiturates
nicotine[no description available]medium1503-(1-methylpyrrolidin-2-yl)pyridineanxiolytic drug;
biomarker;
immunomodulator;
mitogen;
neurotoxin;
nicotinic acetylcholine receptor agonist;
peripheral nervous system drug;
phytogenic insecticide;
plant metabolite;
psychotropic drug;
teratogenic agent;
xenobiotic
tyramine[no description available]medium200monoamine molecular messenger;
primary amino compound;
tyramines		EC 3.1.1.8 (cholinesterase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter
acetaldehyde[no description available]medium10aldehydecarcinogenic agent;
EC 3.5.1.4 (amidase) inhibitor;
electron acceptor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
mutagen;
oxidising agent;
Saccharomyces cerevisiae metabolite;
teratogenic agent
meprobamate[no description available]medium40organic molecular entity
chlorisondamine[no description available]medium20isoindoles
mephenesin[no description available]medium10aromatic ether;
glycerol ether
mercaptomerin[no description available]medium10
vitamin b 12[no description available]medium10
tetraethylammonium[no description available]medium20quaternary ammonium ion
dicumarol[no description available]medium10hydroxycoumarinanticoagulant;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
Hsp90 inhibitor;
vitamin K antagonist
meperidine[no description available]medium10ethyl ester;
piperidinecarboxylate ester;
tertiary amino compound		antispasmodic drug;
kappa-opioid receptor agonist;
mu-opioid receptor agonist;
opioid analgesic
methadone[no description available]medium10benzenes;
diarylmethane;
ketone;
tertiary amino compound
hyaluronoglucosaminidase[no description available]medium20
hydantoins[no description available]medium10imidazolidine-2,4-dione
tetraethyl pyrophosphate[no description available]medium10organic diphosphate
propane[no description available]medium10alkane;
gas molecular entity		food propellant
ouabain[no description available]medium2011alpha-hydroxy steroid;
14beta-hydroxy steroid;
5beta-hydroxy steroid;
alpha-L-rhamnoside;
cardenolide glycoside;
steroid hormone		anti-arrhythmia drug;
cardiotonic drug;
EC 2.3.3.1 [citrate (Si)-synthase] inhibitor;
EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor;
ion transport inhibitor;
plant metabolite
propranolol[no description available]medium1270naphthalenes;
propanolamine;
secondary amine		anti-arrhythmia drug;
antihypertensive agent;
anxiolytic drug;
beta-adrenergic antagonist;
environmental contaminant;
human blood serum metabolite;
vasodilator agent;
xenobiotic
tubocurarine[no description available]medium60bisbenzylisoquinoline alkaloiddrug allergen;
muscle relaxant;
nicotinic antagonist
isoflurophate[no description available]medium10dialkyl phosphate
diphenhydramine[no description available]medium70ether;
tertiary amino compound		anti-allergic agent;
antidyskinesia agent;
antiemetic;
antiparkinson drug;
antipruritic drug;
antitussive;
H1-receptor antagonist;
local anaesthetic;
muscarinic antagonist;
oneirogen;
sedative
thyroxine[no description available]medium202-halophenol;
iodophenol;
L-phenylalanine derivative;
non-proteinogenic L-alpha-amino acid;
thyroxine zwitterion;
thyroxine		antithyroid drug;
human metabolite;
mouse metabolite;
thyroid hormone
lysergic acid diethylamide[no description available]medium90ergoline alkaloid;
monocarboxylic acid amide;
organic heterotetracyclic compound		dopamine agonist;
hallucinogen;
serotonergic agonist
methyldopa[no description available]medium110L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid		alpha-adrenergic agonist;
antihypertensive agent;
hapten;
peripheral nervous system drug;
sympatholytic agent
theophylline[no description available]medium160dimethylxanthineadenosine receptor antagonist;
anti-asthmatic drug;
anti-inflammatory agent;
bronchodilator agent;
drug metabolite;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
fungal metabolite;
human blood serum metabolite;
immunomodulator;
muscle relaxant;
vasodilator agent
aldosterone[no description available]medium3011beta-hydroxy steroid;
18-oxo steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid hormone;
mineralocorticoid;
primary alpha-hydroxy ketone;
steroid aldehyde		human metabolite;
mouse metabolite
pilocarpine[no description available]medium100pilocarpineantiglaucoma drug
pentylenetetrazole[no description available]medium40organic heterobicyclic compound;
organonitrogen heterocyclic compound
phenytoin[no description available]medium20imidazolidine-2,4-dioneanticonvulsant;
drug allergen;
sodium channel blocker;
teratogenic agent
phenobarbital[no description available]medium30barbituratesanticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative
aminophylline[no description available]medium20mixturebronchodilator agent;
cardiotonic drug
lithium[no description available]medium10alkali metal atom
manganese[no description available]medium10elemental manganese;
manganese group element atom		Escherichia coli metabolite;
micronutrient
neostigmine[no description available]medium30quaternary ammonium ionantidote to curare poisoning;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
dextromoramide[no description available]medium20morpholines;
N-acylpyrrolidine		opioid analgesic
haloperidol[no description available]medium60aromatic ketone;
hydroxypiperidine;
monochlorobenzenes;
organofluorine compound;
tertiary alcohol		antidyskinesia agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist
chloral hydrate[no description available]medium20aldehyde hydrate;
ethanediol;
organochlorine compound		general anaesthetic;
mouse metabolite;
sedative;
xenobiotic
methoxamine[no description available]medium30amphetaminesalpha-adrenergic agonist;
antihypotensive agent
dihydroergotamine[no description available]medium10ergot alkaloid;
semisynthetic derivative		dopamine agonist;
non-narcotic analgesic;
serotonergic agonist;
sympatholytic agent;
vasoconstrictor agent
oxotremorine[no description available]medium30N-alkylpyrrolidine
hexamethonium[no description available]medium20quaternary ammonium salt
thiourea[no description available]medium40one-carbon compound;
thioureas;
ureas		antioxidant;
chromophore
dimaprit[no description available]medium30imidothiocarbamic ester
4-methylhistamine[no description available]medium10aralkylamino compound;
imidazoles		histamine agonist;
metabolite
cyclic gmp[no description available]medium203',5'-cyclic purine nucleotide;
guanyl ribonucleotide		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
fluorides[no description available]medium10halide anion;
monoatomic fluorine
sodium fluoride[no description available]medium20fluoride saltmutagen
gallopamil[no description available]medium30benzenes;
organic amino compound
timolol[no description available]medium20timololanti-arrhythmia drug;
antiglaucoma drug;
antihypertensive agent;
beta-adrenergic antagonist
benzofurans[no description available]medium10
ro 03-7894[no description available]medium10
n,n-dimethyl-n',n'-dibenzylethylenediamine[no description available]medium10
chlorine[no description available]medium40halide anion;
monoatomic chlorine		cofactor;
Escherichia coli metabolite;
human metabolite
octylonium[no description available]medium10benzamides
verapamil[no description available]medium50aromatic ether;
nitrile;
polyether;
tertiary amino compound
furtrethonium[no description available]medium10aralkylamine
4,4'-diisothiocyanostilbene-2,2'-disulfonic acid[no description available]medium10
4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid[no description available]medium10stilbenoid
dihydro-dids[no description available]medium10
colchicine[no description available]medium10alkaloid;
colchicine		anti-inflammatory agent;
gout suppressant;
mutagen
egtazic acid[no description available]medium20diether;
tertiary amino compound;
tetracarboxylic acid		chelator
calcimycin[no description available]medium10benzoxazole
lanthanum[no description available]medium10f-block element atom;
lanthanoid atom;
scandium group element atom
piperonyl butoxide[no description available]medium10benzodioxolespesticide synergist
cobalt[no description available]medium20cobalt group element atom;
metal allergen		micronutrient
proadifen[no description available]medium20diarylmethane
luteoskyrin[no description available]medium10
naphthoquinones[no description available]medium10
sauvagine[no description available]medium10
alprenolol[no description available]medium20secondary alcohol;
secondary amino compound		anti-arrhythmia drug;
antihypertensive agent;
beta-adrenergic antagonist;
sympatholytic agent
nad[no description available]medium10organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
nadp[no description available]medium10
mannomustine[no description available]medium10amino alcohol
clorgyline[no description available]medium10aromatic ether;
dichlorobenzene;
terminal acetylenic compound;
tertiary amino compound		antidepressant;
EC 1.4.3.4 (monoamine oxidase) inhibitor
ketamine[no description available]medium20cyclohexanones;
monochlorobenzenes;
secondary amino compound		analgesic;
environmental contaminant;
intravenous anaesthetic;
neurotoxin;
NMDA receptor antagonist;
xenobiotic
adenosine-5'-(n-ethylcarboxamide)[no description available]medium10adenosines;
monocarboxylic acid amide		adenosine A1 receptor agonist;
adenosine A2A receptor agonist;
antineoplastic agent;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
vasodilator agent
n-methyladenosine[no description available]medium10methyladenosine
adenosine[no description available]medium10adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent
n(6)-cyclohexyladenosine[no description available]medium10
bucladesine[no description available]medium403',5'-cyclic purine nucleotide
galantide[no description available]medium10
substance p[no description available]medium10peptideneurokinin-1 receptor agonist;
neurotransmitter;
vasodilator agent
dimethyl sulfoxide[no description available]medium10sulfoxide;
volatile organic compound		alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger
glyburide[no description available]medium10monochlorobenzenes;
N-sulfonylurea		anti-arrhythmia drug;
EC 2.7.1.33 (pantothenate kinase) inhibitor;
EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor;
hypoglycemic agent
diltiazem[no description available]medium205-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetateantihypertensive agent;
calcium channel blocker;
vasodilator agent
spironolactone[no description available]medium103-oxo-Delta(4) steroid;
oxaspiro compound;
steroid lactone;
thioester		aldosterone antagonist;
antihypertensive agent;
diuretic;
environmental contaminant;
xenobiotic
benextramine[no description available]medium10
cystamine[no description available]medium20organic disulfide;
primary amino compound		EC 2.3.2.13 (protein-glutamine gamma-glutamyltransferase) inhibitor
edetic acid[no description available]medium30ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid		anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector
methysergide[no description available]medium110ergoline alkaloid
tretoquinol[no description available]medium10isoquinolines
barium[no description available]medium100alkaline earth metal atom;
elemental barium
pyrilamine[no description available]medium20aromatic ether;
ethylenediamine derivative		H1-receptor antagonist
tetragastrin[no description available]medium20peptidyl amide;
tetrapeptide		anxiogenic;
human metabolite
metiamide[no description available]medium10imidazoles
azapetine[no description available]medium10benzazepine
mepiperphenidol[no description available]medium10benzenes;
organic amino compound
piperidines[no description available]medium40
niacinamide[no description available]medium60pyridine alkaloid;
pyridinecarboxamide;
vitamin B3		anti-inflammatory agent;
antioxidant;
cofactor;
EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
Escherichia coli metabolite;
geroprotector;
human urinary metabolite;
metabolite;
mouse metabolite;
neuroprotective agent;
Saccharomyces cerevisiae metabolite;
Sir2 inhibitor
probenecid[no description available]medium10benzoic acids;
sulfonamide		uricosuric drug
cyanides[no description available]medium20pseudohalide anionEC 1.9.3.1 (cytochrome c oxidase) inhibitor
sodium dodecyl sulfate[no description available]medium10organic sodium saltdetergent;
protein denaturant
lobeline[no description available]medium20
4-chloromercuribenzenesulfonate[no description available]medium10arenesulfonic acid;
arylmercury compound
glycine[no description available]medium10alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
proline[no description available]medium10amino acid zwitterion;
glutamine family amino acid;
L-alpha-amino acid;
proline;
proteinogenic amino acid		algal metabolite;
compatible osmolytes;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
asparagine[no description available]medium10amino acid zwitterion;
asparagine;
aspartate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
glutamine[no description available]medium10amino acid zwitterion;
glutamine family amino acid;
glutamine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
Escherichia coli metabolite;
human metabolite;
metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
aminooxyacetic acid[no description available]medium10amino acid;
hydroxylamines;
monocarboxylic acid		anticonvulsant;
EC 2.6.1.19 (4-aminobutyrate--2-oxoglutarate transaminase) inhibitor;
EC 4.2.1.22 (cystathionine beta-synthase) inhibitor;
nootropic agent
apomorphine[no description available]medium50aporphine alkaloidalpha-adrenergic drug;
antidyskinesia agent;
antiparkinson drug;
dopamine agonist;
emetic;
serotonergic drug
angiotensin ii[no description available]medium120amino acid zwitterion;
angiotensin II		human metabolite
oxytocin[no description available]medium90heterodetic cyclic peptide;
peptide hormone		oxytocic;
vasodilator agent
desoxycorticosterone[no description available]medium4020-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
mineralocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
cysteine[no description available]medium10cysteiniumfundamental metabolite
phosphatidylcholines[no description available]medium101,2-diacyl-sn-glycero-3-phosphocholine
burimamide[no description available]medium10imidazoles
thiosulfates[no description available]medium40divalent inorganic anion;
sulfur oxide;
sulfur oxoanion		human metabolite
fenclonine[no description available]medium30phenylalanine derivative
cimetidine[no description available]medium20aliphatic sulfide;
guanidines;
imidazoles;
nitrile		adjuvant;
analgesic;
anti-ulcer drug;
H2-receptor antagonist;
P450 inhibitor
promethazine[no description available]medium20phenothiazines;
tertiary amine		anti-allergic agent;
anticoronaviral agent;
antiemetic;
antipruritic drug;
H1-receptor antagonist;
local anaesthetic;
sedative
clonidine[no description available]medium60clonidine;
imidazoline
ovalbumin[no description available]medium10
bemegride[no description available]medium20piperidones
diazepam[no description available]medium201,4-benzodiazepinone;
organochlorine compound		anticonvulsant;
anxiolytic drug;
environmental contaminant;
sedative;
xenobiotic
cyproheptadine[no description available]medium90piperidines;
tertiary amine		anti-allergic agent;
antipruritic drug;
gastrointestinal drug;
H1-receptor antagonist;
serotonergic antagonist
pimozide[no description available]medium30benzimidazoles;
heteroarylpiperidine;
organofluorine compound		antidyskinesia agent;
dopaminergic antagonist;
first generation antipsychotic;
H1-receptor antagonist;
serotonergic antagonist
ergonovine[no description available]medium20ergot alkaloid;
monocarboxylic acid amide;
organic heterotetracyclic compound;
primary alcohol;
secondary amino compound;
tertiary amino compound		diagnostic agent;
fungal metabolite;
oxytocic;
toxin
muscarine[no description available]medium10monosaccharide
nifedipine[no description available]medium10C-nitro compound;
dihydropyridine;
methyl ester		calcium channel blocker;
human metabolite;
tocolytic agent;
vasodilator agent
practolol[no description available]medium40acetamides;
ethanolamines;
propanolamine;
secondary alcohol;
secondary amino compound		anti-arrhythmia drug;
beta-adrenergic antagonist
dihydroergotoxine[no description available]medium10
tetrodotoxin[no description available]medium70azatetracycloalkane;
oxatetracycloalkane;
quinazoline alkaloid		animal metabolite;
bacterial metabolite;
marine metabolite;
neurotoxin;
voltage-gated sodium channel blocker
picrotoxin[no description available]medium80
bicuculline[no description available]medium20benzylisoquinoline alkaloid;
isoquinoline alkaloid;
isoquinolines		agrochemical;
central nervous system stimulant;
GABA-gated chloride channel antagonist;
GABAA receptor antagonist;
neurotoxin
strychnine[no description available]medium80monoterpenoid indole alkaloid;
organic heteroheptacyclic compound		avicide;
cholinergic antagonist;
glycine receptor antagonist;
neurotransmitter agent;
rodenticide
moxidectin[no description available]medium10
bunazosin[no description available]medium10quinazolines
quinazolines[no description available]medium10azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinazolines
bethanechol[no description available]medium10carbamate ester;
quaternary ammonium ion		muscarinic agonist
triiodothyronine[no description available]medium102-halophenol;
amino acid zwitterion;
iodophenol;
iodothyronine		human metabolite;
mouse metabolite;
thyroid hormone
pindolol[no description available]medium10indoles;
secondary amine		antiglaucoma drug;
antihypertensive agent;
beta-adrenergic antagonist;
serotonergic antagonist;
vasodilator agent
desipramine[no description available]medium50dibenzoazepine;
secondary amino compound		adrenergic uptake inhibitor;
alpha-adrenergic antagonist;
antidepressant;
cholinergic antagonist;
drug allergen;
EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
H1-receptor antagonist;
serotonin uptake inhibitor
strontium[no description available]medium20alkaline earth metal atom
scopolamine hydrobromide[no description available]medium50
naphazoline[no description available]medium30naphthalenes
proglumide[no description available]medium10benzamides;
dicarboxylic acid monoamide;
glutamine derivative;
racemate		anti-ulcer drug;
cholecystokinin antagonist;
cholinergic antagonist;
delta-opioid receptor agonist;
drug metabolite;
gastrointestinal drug;
opioid analgesic;
xenobiotic metabolite
cholecystokinin[no description available]medium20
quipazine[no description available]medium10piperazines;
pyridines
guanosine triphosphate[no description available]medium10guanosine 5'-phosphate;
purine ribonucleoside 5'-triphosphate		Escherichia coli metabolite;
mouse metabolite;
uncoupling protein inhibitor
8-hydroxy-2-(di-n-propylamino)tetralin[no description available]medium10phenols;
tertiary amino compound;
tetralins		serotonergic antagonist
n,n-dimethyltryptamine[no description available]medium10tryptamine alkaloid;
tryptamines
5-methoxytryptamine[no description available]medium10aromatic ether;
primary amino compound;
tryptamines		5-hydroxytryptamine 2A receptor agonist;
5-hydroxytryptamine 2B receptor agonist;
5-hydroxytryptamine 2C receptor agonist;
antioxidant;
cardioprotective agent;
human metabolite;
mouse metabolite;
neuroprotective agent;
radiation protective agent;
serotonergic agonist
tryptamine[no description available]medium10aminoalkylindole;
aralkylamino compound;
indole alkaloid;
tryptamines		human metabolite;
mouse metabolite;
plant metabolite
bufotenin[no description available]medium10tertiary amine;
tryptamine alkaloid		coral metabolite;
hallucinogen
n-methyltryptamine[no description available]medium10tryptamine alkaloid;
tryptamines		metabolite
1-(3-trifluoromethylphenyl)piperazine[no description available]medium10(trifluoromethyl)benzenes;
N-arylpiperazine		environmental contaminant;
psychotropic drug;
serotonergic agonist;
xenobiotic
5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole[no description available]medium10indoles
talipexole[no description available]medium10azepine
metaraminol[no description available]medium40phenylethanolaminesalpha-adrenergic agonist;
sympathomimetic agent;
vasoconstrictor agent
propylbenzilylcholine mustard[no description available]medium10
cosyntropin[no description available]medium10
physostigmine salicylate[no description available]medium10azaheterocycle salicylate salt;
salicylates
gamma-aminobutyric acid[no description available]medium10amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid		human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule
hexylresorcinol[no description available]medium10resorcinols
pyrantel tartrate[no description available]medium10
piperazine[no description available]medium10azacycloalkane;
piperazines;
saturated organic heteromonocyclic parent		anthelminthic drug
dimethylphenylpiperazinium iodide[no description available]medium10N-arylpiperazine;
organic iodide salt;
piperazinium salt;
quaternary ammonium salt		nicotinic acetylcholine receptor agonist
diethylcarbamazine[no description available]medium10N-carbamoylpiperazine;
N-methylpiperazine
beta-carboline-3-carboxylic acid ethyl ester[no description available]medium10beta-carbolines
beta-carboline-3-carboxylic acid methyl ester[no description available]medium10beta-carbolines
isocarboxazid[no description available]medium30benzenes
dihydroxyphenylalanine[no description available]medium80hydroxyphenylalanine;
non-proteinogenic alpha-amino acid;
tyrosine derivative		human metabolite
quinidine[no description available]medium40cinchona alkaloidalpha-adrenergic antagonist;
anti-arrhythmia drug;
antimalarial;
drug allergen;
EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor;
EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor;
muscarinic antagonist;
P450 inhibitor;
potassium channel blocker;
sodium channel blocker
potassium chloride[no description available]medium30inorganic chloride;
inorganic potassium salt;
potassium salt		fertilizer
tetracaine[no description available]medium20benzoate ester;
tertiary amino compound		local anaesthetic
lidocaine[no description available]medium30benzenes;
monocarboxylic acid amide;
tertiary amino compound		anti-arrhythmia drug;
drug allergen;
environmental contaminant;
local anaesthetic;
xenobiotic
hydroxyindoleacetic acid[no description available]medium10indole-3-acetic acidsdrug metabolite;
human metabolite;
mouse metabolite
5-hydroxytryptophan[no description available]medium40hydroxytryptophanhuman metabolite;
neurotransmitter
chlorpheniramine[no description available]medium50monochlorobenzenes;
pyridines;
tertiary amino compound		anti-allergic agent;
antidepressant;
antipruritic drug;
H1-receptor antagonist;
histamine antagonist;
serotonin uptake inhibitor
adenine[no description available]medium106-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
phosphorus radioisotopes[no description available]medium10
1-propanol[no description available]medium30propan-1-ols;
short-chain primary fatty alcohol		metabolite;
protic solvent
methamphetamine[no description available]medium20amphetamines;
secondary amine		central nervous system stimulant;
environmental contaminant;
neurotoxin;
psychotropic drug;
xenobiotic
isoniazid[no description available]medium10carbohydrazideantitubercular agent;
drug allergen
caffeine[no description available]medium50purine alkaloid;
trimethylxanthine		adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic
caseins[no description available]medium10
albuterol[no description available]medium10phenols;
phenylethanolamines;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
environmental contaminant;
xenobiotic
terbutaline[no description available]medium10phenylethanolamines;
resorcinols		anti-asthmatic drug;
beta-adrenergic agonist;
bronchodilator agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
hypoglycemic agent;
sympathomimetic agent;
tocolytic agent
alpha-chymotrypsin[no description available]medium20
moxisylyte[no description available]medium10monoterpenoid
carbon tetrachloride[no description available]medium30chlorocarbon;
chloromethanes		hepatotoxic agent;
refrigerant
corticosterone[no description available]medium3011beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
croton oil[no description available]medium10N-acyl-hexosamine
thymidine[no description available]medium10pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
oxazoles[no description available]medium101,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
nialamide[no description available]medium40organonitrogen compound;
organooxygen compound
benactyzine[no description available]medium30diarylmethane
imipramine[no description available]medium60dibenzoazepineadrenergic uptake inhibitor;
antidepressant;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
phenyl acetate[no description available]medium10benzenes;
phenyl acetates
isosorbide dinitrate[no description available]medium10glucitol derivative;
nitrate ester		nitric oxide donor;
vasodilator agent
normetanephrine[no description available]medium20catecholamine
phosphocreatine[no description available]medium30phosphagen;
phosphoamino acid		human metabolite;
mouse metabolite
p-methoxy-n-methylphenethylamine[no description available]medium10aromatic ether;
secondary amino compound		metabolite
scandium[no description available]medium10d-block element atom;
rare earth metal atom;
scandium group element atom
lead[no description available]medium10carbon group element atom;
elemental lead;
metal atom		neurotoxin
formaldehyde[no description available]medium10aldehyde;
one-carbon compound		allergen;
carcinogenic agent;
disinfectant;
EC 3.5.1.4 (amidase) inhibitor;
environmental contaminant;
Escherichia coli metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
thromboplastin[no description available]medium10
ethacrynic acid[no description available]medium10aromatic ether;
aromatic ketone;
dichlorobenzene;
monocarboxylic acid		EC 2.5.1.18 (glutathione transferase) inhibitor;
ion transport inhibitor;
loop diuretic
oligomycins[no description available]medium10
sotalol[no description available]medium20ethanolamines;
secondary alcohol;
secondary amino compound;
sulfonamide		anti-arrhythmia drug;
beta-adrenergic antagonist;
environmental contaminant;
xenobiotic
glycogen[no description available]medium10
dextroamphetamine[no description available]medium501-phenylpropan-2-amineadrenergic agent;
adrenergic uptake inhibitor;
dopamine uptake inhibitor;
dopaminergic agent;
neurotoxin;
sympathomimetic agent
mecamylamine[no description available]medium60primary aliphatic amine
nortriptyline[no description available]medium10organic tricyclic compound;
secondary amine		adrenergic uptake inhibitor;
analgesic;
antidepressant;
antineoplastic agent;
apoptosis inducer;
drug metabolite
morphine[no description available]medium120morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic
pyrogallol[no description available]medium80benzenetriol;
phenolic donor		plant metabolite
succinylcholine[no description available]medium10quaternary ammonium ion;
succinate ester		drug allergen;
muscle relaxant;
neuromuscular agent
bromine[no description available]medium20diatomic bromine
bradykinin[no description available]medium30oligopeptidehuman blood serum metabolite;
vasodilator agent
arginine[no description available]medium10arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical
amantadine[no description available]medium10adamantanes;
primary aliphatic amine		analgesic;
antiparkinson drug;
antiviral drug;
dopaminergic agent;
NMDA receptor antagonist;
non-narcotic analgesic
disulfiram[no description available]medium20organic disulfide;
organosulfur acaricide		angiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor;
EC 3.1.1.1 (carboxylesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
ferroptosis inducer;
fungicide;
NF-kappaB inhibitor
phenylalanine[no description available]medium10amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid		algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
perphenazine[no description available]medium10N-(2-hydroxyethyl)piperazine;
N-alkylpiperazine;
organochlorine compound;
phenothiazines		antiemetic;
dopaminergic antagonist;
phenothiazine antipsychotic drug
pargyline[no description available]medium20aromatic amine
chloroform[no description available]medium50chloromethanes;
one-carbon compound		carcinogenic agent;
central nervous system drug;
inhalation anaesthetic;
non-polar solvent;
refrigerant
procainamide[no description available]medium10benzamidesanti-arrhythmia drug;
platelet aggregation inhibitor;
sodium channel blocker
aminopyrine[no description available]medium10pyrazolone;
tertiary amino compound		antipyretic;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
mefenamic acid[no description available]medium10aminobenzoic acid;
secondary amino compound		analgesic;
antipyretic;
antirheumatic drug;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
non-steroidal anti-inflammatory drug;
xenobiotic
phenelzine[no description available]medium20primary amine
puromycin[no description available]medium10puromycinsantiinfective agent;
antimicrobial agent;
antineoplastic agent;
EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor;
EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor;
nucleoside antibiotic;
protein synthesis inhibitor
ampicillin[no description available]medium10beta-lactam antibiotic;
penicillin allergen;
penicillin		antibacterial drug
toluene[no description available]medium10methylbenzene;
toluenes;
volatile organic compound		cholinergic antagonist;
fuel additive;
neurotoxin;
non-polar solvent
diazoxide[no description available]medium10benzothiadiazine;
organochlorine compound;
sulfone		antihypertensive agent;
beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
diuretic;
K-ATP channel agonist;
sodium channel blocker;
sympathomimetic agent;
vasodilator agent
dibucaine[no description available]medium10aromatic ether;
monocarboxylic acid amide;
tertiary amino compound		topical anaesthetic
indomethacin[no description available]medium10aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
pempidine[no description available]medium30piperidines
ascorbic acid[no description available]medium30ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
sucrose[no description available]medium10glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
mercury[no description available]medium10elemental mercury;
zinc group element atom		neurotoxin
ethylmaleimide[no description available]medium10maleimidesanticoronaviral agent;
EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor;
EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor;
EC 2.7.1.1 (hexokinase) inhibitor
dimethylformamide[no description available]medium10formamides;
volatile organic compound		geroprotector;
hepatotoxic agent;
polar aprotic solvent
chlorine[no description available]medium30diatomic chlorine;
gas molecular entity		bleaching agent
urea[no description available]medium10isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
trimethadione[no description available]medium10oxazolidinoneanticonvulsant;
geroprotector
amobarbital[no description available]medium10barbiturates
arecoline[no description available]medium10enoate ester;
methyl ester;
pyridine alkaloid;
tetrahydropyridine		metabolite;
muscarinic agonist
obidoxime chloride[no description available]medium10
furaldehyde[no description available]medium10aldehyde;
furans		Maillard reaction product;
metabolite
bromide[no description available]medium10halide anion;
monoatomic bromine
hemicholinium 3[no description available]medium10
beta-aminoethyl isothiourea[no description available]medium10
thioacetamide[no description available]medium10thiocarboxamidehepatotoxic agent
galactose[no description available]medium10
cysteamine[no description available]medium10amine;
thiol		geroprotector;
human metabolite;
mouse metabolite;
radiation protective agent
methanol[no description available]medium20alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound		amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite
thiopental[no description available]medium10barbituratesanticonvulsant;
drug allergen;
environmental contaminant;
intravenous anaesthetic;
sedative;
xenobiotic
tranylcypromine[no description available]medium102-phenylcyclopropan-1-amine
pentazocine[no description available]medium10benzazocine
eledoisin[no description available]medium20peptide
tetrabenazine[no description available]medium20benzoquinolizine;
cyclic ketone;
tertiary amino compound
chondroitin[no description available]medium10
limestone[no description available]medium10calcium salt;
carbonate salt;
inorganic calcium salt;
one-carbon compound		antacid;
fertilizer;
food colouring;
food firming agent
trichloroacetic acid[no description available]medium10monocarboxylic acid;
organochlorine compound		carcinogenic agent;
metabolite;
mouse metabolite
tromethamine[no description available]medium10primary amino compound;
triol		buffer
metyrapone[no description available]medium10aromatic ketoneantimetabolite;
diagnostic agent;
EC 1.14.15.4 (steroid 11beta-monooxygenase) inhibitor
chlordiazepoxide[no description available]medium10benzodiazepine
tyrosine[no description available]medium10amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
tremorine[no description available]medium10N-alkylpyrrolidine
carbon monoxide[no description available]medium10carbon oxide;
gas molecular entity;
one-carbon compound		biomarker;
EC 1.9.3.1 (cytochrome c oxidase) inhibitor;
human metabolite;
ligand;
metabolite;
mitochondrial respiratory-chain inhibitor;
mouse metabolite;
neurotoxin;
neurotransmitter;
P450 inhibitor;
probe;
signalling molecule;
vasodilator agent
azides[no description available]medium10pseudohalide anionmitochondrial respiratory-chain inhibitor
aspirin[no description available]medium10benzoic acids;
phenyl acetates;
salicylates		anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent
stilbenes[no description available]medium10stilbene
trolamine salicylate[no description available]medium10
digitoxin[no description available]medium10cardenolide glycosideEC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor
fomesafen[no description available]medium50aromatic ether;
C-nitro compound;
monochlorobenzenes;
N-sulfonylcarboxamide;
organofluorine compound;
phenols		agrochemical;
EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide
eye[no description available]medium20
egg white[no description available]medium10
humulene[no description available]medium10alpha-humulene
2-propanol[no description available]medium20secondary alcohol;
secondary fatty alcohol		protic solvent
apnea[no description available]medium10purine nucleoside
ConditionIndicatedRelationship StrengthStudiesTrials
Abnormality, Heart0low10
Abscess0low10
Absence Seizure0low40
Absence Seizures0low40
Achalasia0low10
Achalasia, Esophageal0low10
Ache0low10
Acidosis0low10
Acidosis, Respiratory0low10
Active Hyperemia0low30
Acute Disease0low10
Acute Hypercapnic Respiratory Failure0low20
Acute Hypoxemic Respiratory Failure0low20
Acute Liver Injury, Drug-Induced0low30
Acute Radiation Syndrome0low10
Addison's Anemia0low10
Adenohypophyseal Diseases0low10
Aging0low10
Air Sickness0low10
Airsickness0low10
Aldosteronism0low10
Allergic Reaction0low20
Allergy0low20
Alloxan Diabetes0low10
Amyloidosis0low10
Anaphylactic Reaction0low60
Anaphylactoid Reaction0low60
Anaphylactoid Shock0low60
Anaphylaxis0low60
Anasarca0low70
Anemia0low10
Anemia, Addison's0low10
Anemia, Pernicious0low10
Anesthesia0low50
Anochlesia0low10
Anoxemia0low90
Anoxia0low90
Anterior Pituitary Diseases0low10
Anxiety0low10
Apnea0low10
Arrhythmia0low90
Arrhythmias, Cardiac0low90
Arrythmia0low90
Arterial Hyperemia0low30
Arteriosclerosis0low10
Arthritis0low10
Arthritis, Rheumatoid0low10
Arthus Phenomenon0low10
Arthus Reaction0low10
Ascorbic Acid Deficiency0low10
Asthma0low10
Asthma, Bronchial0low10
Atonic Absence Seizure0low40
Atonic Absence Seizures0low40
Atonic Seizure0low40
Atonic Seizures0low40
Atopic Hypersensitivity0low10
Atrial Fibrillation0low10
Aura0low10
Auricular Fibrillation0low10
Awakening Epilepsy0low10
Bacterial Endocarditides0low10
Bacterial Endocarditis0low10
Benign Neoplasms0low40
Bleeding0low120
Blepharoptosis0low10
Blood Clot0low40
Blood Coagulation Disorders0low10
Blood Poisoning0low10
Blood Pressure, High0low190
Blood Pressure, Low0low30
Bloodstream Infection0low10
Body Weight0low40
Bradyarrhythmia0low30
Bradyarrhythmias0low30
Bradycardia0low30
Bronchial Asthma0low10
Bronchial Spasm0low20
Bronchospasm0low20
Burns0low20
Cancer0low40
Cancer of Esophagus0low10
Cancer of Liver0low10
Cancer of Mouth0low10
Cancer of Pharynx0low10
Cancer of the Esophagus0low10
Cancer of the Liver0low10
Cancer of the Mouth0low10
Cancer of the Pharynx0low10
Cancer, Hepatocellular0low10
Car Sickness0low10
Carbon Tetrachloride Poisoning0low20
Cardiac Arrhythmia0low90
Cardiac Arrhythmias0low90
Cardiac Diseases0low10
Cardiac Disorders0low10
Cardiac Dysrhythmia0low90
Cardiac Failure0low40
Cardiomyopathies0low10
Cardiomyopathies, Primary0low10
Cardiomyopathies, Secondary0low10
Cardiomyopathy, Chagas0low20
Cardiospasm0low10
Cardiovascular Diseases0low10
Cardiovascular Stroke0low10
Carditis0low10
Carsickness0low10
Catalepsy0low10
CCl4 Poisoning0low20
Cerea Flexibilitas0low10
Chagas Cardiomyopathy0low20
Chagas' Cardiomyopathy0low20
Chemical and Drug Induced Liver Injury0low30
Chemical Dependence0low10
Chemically-Induced Liver Toxicity0low30
Choline Deficiency0low10
Chronic Disease0low10
Chronic Illness0low10
Chronic Primary Open Angle Glaucoma0low10
Chronically Ill0low10
Circulatory Collapse0low70
Circulatory Failure0low70
Clonic Seizure0low40
Clonic Seizures0low40
Coagulation Disorders, Blood0low10
Coagulation, Disseminated Intravascular0low10
Complex Partial Seizure0low40
Complex Partial Seizures0low40
Congenital Heart Defect0low10
Congenital Heart Defects0low10
Congenital Heart Disease0low10
Congenital Myotonic Dystrophy0low10
Congestive Heart Failure0low40
Conn Syndrome0low10
Conn's Syndrome0low10
Consumption Coagulopathy0low10
Convulsion0low40
Convulsion, Non-Epileptic0low40
Convulsions0low40
Convulsive Seizure0low40
Convulsive Seizures0low40
Cyst0low10
Cysts0low10
Decerebrate Posturing0low40
Decerebrate State0low40
Decorticate Rigidity0low40
Decorticate State0low40
Defects, Congenital Heart0low10
Deficiency, Ascorbic Acid0low10
Deficiency, Choline0low10
Deficiency, Oxygen0low90
Deficiency, Vitamin C0low10
Dehydration0low10
Delayed Hypersensitivity0low10
Dementia Praecox0low10
Diabetes Mellitus, Experimental0low10
Disease Models, Animal0low40
Diseases, Peripheral Vascular0low30
Disorders, Blood Coagulation0low10
Disseminated Coagulation, Intravascular0low10
Disseminated Intravascular Coagulation0low10
Dropsy0low70
Drug Abuse0low10
Drug Addiction0low10
Drug Dependence0low10
Drug Habituation0low10
Drug Use Disorders0low10
Drug-Induced Acute Liver Injury0low30
Drug-Induced Liver Disease0low30
Drug-Induced Liver Injury0low30
Dystrophia Myotonica0low10
Dystrophia Myotonica 10low10
Dystrophia Myotonica 20low10
Edema0low70
Edema, Pulmonary0low40
Edemas, Pulmonary0low40
Encephalitis, Polio0low10
Endocarditides, Bacterial0low10
Endocarditis, Bacterial0low10
Endotoxin Shock0low30
Enteric Fever0low10
Eosinophilia0low10
Eosinophilia, Tropical0low10
Epidemic Acute Poliomyelitis0low10
Epilepsy0low10
Epilepsy, Cryptogenic0low10
Epileptic Seizure0low40
Epileptic Seizures0low40
Esophageal Achalasia0low10
Esophageal Cancer0low10
Esophageal Neoplasms0low10
Esophagus Cancer0low10
Esophagus Neoplasm0low10
Experimental Diabetes Mellitus0low10
Experimental Mammary Neoplasms0low10
Experimental Neoplasms0low30
Experimental Radiation Injuries0low10
Extravascular Hemolysis0low10
Eye Diseases0low10
Eye Disorders0low10
Familial Atrial Fibrillation0low10
Fever0low20
Flaccid Quadriplegia0low10
Flaccid Tetraplegia0low10
Flexibility, Waxy0low10
Foot Diseases0low10
Gastric Fistula0low10
Gastric Ulcer0low50
Gastroduodenal Ulcer0low10
Gastrointestinal Hemorrhage0low10
Generalized Absence Seizure0low40
Generalized Absence Seizures0low40
Generalized Tonic-Clonic Seizures0low40
Genetic Predisposition0low10
Genetic Predisposition to Disease0low10
Genetic Susceptibility0low10
Glaucoma0low70
Glaucoma Simplex0low10
Glaucoma, Angle Closure0low10
Glaucoma, Angle-Closure0low10
Glaucoma, Closed-Angle0low10
Glaucoma, Compensated0low10
Glaucoma, Compensative0low10
Glaucoma, Narrow-Angle0low10
Glaucoma, Open Angle0low10
Glaucoma, Open-Angle0low10
Glaucoma, Pigmentary0low10
Glaucoma, Primary Open Angle0low10
Glaucoma, Secondary Open Angle0low10
Glaucoma, Simple0low10
Glaucoma, Uncompensated0low10
Glaucoma, Uncompensative0low10
Group A Strep Infection0low10
Group A Streptococcal Infection0low10
Group A Streptococcal Infections0low10
Group B Strep Infection0low10
Group B Streptococcal Infection0low10
Group B Streptococcal Infections0low10
Haemolysis0low10
Hallucination of Body Sensation0low10
Hallucinations0low10
Hallucinations, Auditory0low10
Hallucinations, Dissociative0low10
Hallucinations, Elementary0low10
Hallucinations, Formed, of People0low10
Hallucinations, Gustatory0low10
Hallucinations, Hypnagogic0low10
Hallucinations, Hypnapompic0low10
Hallucinations, Internal Body Sensation0low10
Hallucinations, Kinesthetic0low10
Hallucinations, Mood Congruent0low10
Hallucinations, Mood Incongruent0low10
Hallucinations, Olfactory0low10
Hallucinations, Organic0low10
Hallucinations, Reflex0low10
Hallucinations, Sensory0low10
Hallucinations, Somatic0low10
Hallucinations, Tactile0low10
Hallucinations, Verbal Auditory0low10
Hallucinations, Visual0low10
Hallucinations, Visual, Formed0low10
Hallucinations, Visual, Unformed0low10
Heart Abnormalities0low10
Heart Attack0low10
Heart Decompensation0low40
Heart Defect, Congenital0low10
Heart Defects, Congenital0low10
Heart Diseases0low10
Heart Disorders0low10
Heart Failure0low40
Heart Failure, Congestive0low40
Heart Failure, Left-Sided0low40
Heart Failure, Right-Sided0low40
Heart, Malformation Of0low10
Hematochezia0low10
Hemolysis0low10
Hemorrhage0low120
Hemorrhage, Gastrointestinal0low10
Hemorrhagic Shock0low60
Hepatic Cancer0low10
Hepatic Neoplasms0low10
Hepatitis, Drug-Induced0low30
Hepatitis, Toxic0low30
Hepatocellular Cancer0low10
Hydrops0low70
Hyperaldosteronism0low10
Hypercapnic Acute Respiratory Failure0low20
Hypercapnic Respiratory Failure0low20
Hyperemia0low30
Hyperglycemia0low60
Hyperglycemia, Postprandial0low60
Hyperkalemia0low30
Hyperpotassemia0low30
Hypersensitivity0low20
Hypersensitivity, Atopic0low10
Hypersensitivity, Delayed0low10
Hypersensitivity, Immediate0low10
Hypersensitivity, Tuberculin-Type0low10
Hypersensitivity, Type I0low10
Hypersensitivity, Type IV0low10
Hypertension0low190
Hypertension, Renal0low10
Hyperthyroid0low10
Hyperthyroidism0low10
Hyponatremia0low20
Hypophyseal Disorders0low10
Hypotension0low30
Hypotension, Vascular0low30
Hypothermia0low20
Hypothermia, Accidental0low20
Hypovolemic Shock0low70
Hypoxemia0low90
Hypoxemic Acute Respiratory Failure0low20
Hypoxemic Respiratory Failure0low20
Hypoxia0low90
IgE-Mediated Hypersensitivity0low10
Infantile Paralysis0low10
Infection0low10
Infection and Infestation0low10
Infections0low10
Infections and Infestations0low10
Infections, Pseudomonas0low10
Infections, Staphylococcal0low20
Infections, Streptococcal0low10
Inflammation0low30
Injuries0low10
Injuries and Wounds0low10
Injuries, Experimental Radiation0low10
Injuries, Soft Tissue0low10
Injuries, Spinal Cord0low10
Injuries, Wounds0low10
Innate Inflammatory Response0low30
Interstitial Nephritis0low10
Intraocular Pressure0low20
Intravascular Coagulation, Disseminated0low10
Intravascular Disseminated Coagulation0low10
Intravascular Hemolysis0low10
Ischemia0low10
Jacksonian Seizure0low40
Kidney Diseases0low10
Left-Sided Heart Failure0low40
Liver Cancer0low10
Liver Injury, Drug-Induced0low30
Liver Injury, Drug-Induced, Acute0low30
Liver Neoplasms0low10
Low Blood Pressure0low30
Malignancy0low40
Malignant Neoplasms0low40
Mammary Neoplasms, Experimental0low10
Marginal Ulcer0low10
Megaesophagus0low10
Metabolic Acidosis0low10
Motion Sickness0low10
Mouth Cancer0low10
Mouth Neoplasms0low10
Muscle Contraction0low910
Muscle Disorders0low20
Muscle Relaxation0low20
Muscular Diseases0low20
Muscular Dystrophy, Animal0low10
Myelopathy0low10
Myelopathy, Traumatic0low10
Myocardial Diseases0low10
Myocardial Diseases, Primary0low10
Myocardial Diseases, Secondary0low10
Myocardial Failure0low40
Myocardial Infarct0low10
Myocardial Infarction0low10
Myocardiopathies0low10
Myocarditis0low10
Myocarditis, Chagas0low20
Myoclonic Seizure0low40
Myoclonic Seizures0low40
Myopathic Conditions0low20
Myopathies0low20
Myotonia Atrophica0low10
Myotonia Dystrophica0low10
Myotonic Dystrophy0low10
Myotonic Dystrophy 10low10
Myotonic Dystrophy 20low10
Myotonic Dystrophy, Congenital0low10
Myotonic Myopathy, Proximal0low10
Necrosis0low50
Neoplasia0low40
Neoplasm0low40
Neoplasms0low40
Neoplasms, Benign0low40
Neoplasms, Esophageal0low10
Neoplasms, Experimental0low30
Neoplasms, Experimental Mammary0low10
Neoplasms, Hepatic0low10
Neoplasms, Liver0low10
Neoplasms, Mouth0low10
Neoplasms, Oral0low10
Neoplasms, Pharyngeal0low10
Neoplasms, Pharynx0low10
Nephritis, Interstitial0low10
Nephritis, Tubulointerstitial0low10
Nerve Degeneration0low10
Neuroblastoma0low20
Neurohypophyseal Diseases0low10
Neuron Degeneration0low10
Neuroses0low10
Neurotic Disorders0low10
Non-Epileptic Seizure0low40
Non-Epileptic Seizures0low40
Nonepileptic Seizure0low40
Nonepileptic Seizures0low40
Obesity0low10
Open-Angle Glaucoma0low10
Oral Cancer0low10
Oral Neoplasms0low10
Organic Mental Disorders, Substance-Induced0low10
Oxygen Deficiency0low90
Pain0low10
Pain, Burning0low10
Pain, Crushing0low10
Pain, Migratory0low10
Pain, Radiating0low10
Pain, Splitting0low10
Paralysis, Spinal, Quadriplegic0low10
Paroxysmal Atrial Fibrillation0low10
Partial Seizure0low40
Partial Seizures0low40
Passive Hyperemia0low30
Peptic Ulcer0low10
Peripheral Angiopathies0low30
Peripheral Vascular Diseases0low30
Pernicious Anemia0low10
Persistent Atrial Fibrillation0low10
Petit Mal Convulsion0low40
Pharnyx Cancer0low10
Pharyngeal Cancer0low10
Pharyngeal Neoplasms0low10
Pharynx Neoplasms0low10
Pheochromocytoma0low40
Pheochromocytoma, Extra-Adrenal0low40
Pituitary Diseases0low10
Pituitary Disorders0low10
Pituitary Gland Diseases0low10
Poisoning, Blood0low10
Poisoning, Carbon Tetrachloride0low20
Poisoning, CCl40low20
Polio0low10
Polio Encephalitis0low10
Poliomyelitis0low10
Poliomyelitis Infection0low10
Poliomyelitis, Acute0low10
Poliomyelitis, Nonpoliovirus0low10
Poliomyelitis, Preparalytic0low10
Polyarthritis0low10
Post-Traumatic Myelopathy0low10
Posterior Pituitary Diseases0low10
Postprandial Hyperglycemia0low60
Predisposition, Genetic0low10
Pregnancy0low130
Prescription Drug Abuse0low10
Primary Hyperaldosteronism0low10
Primary Hyperthyroidism0low10
Primary Myocardial Diseases0low10
Primary Open Angle Glaucoma0low10
PROMM (Proximal Myotonic Myopathy)0low10
Proximal Myotonic Myopathy0low10
Pseudomonas aeruginosa Infection0low10
Pseudomonas Infections0low10
Psychoneuroses0low10
Psychoses, Alcoholic0low10
Psychoses, Drug0low20
Psychoses, Substance-Induced0low20
Psychoses, Toxic0low20
Ptosis, Eyelid0low10
Pulmonary Edema0low40
Pulmonary Edemas0low40
Pyaemia0low10
Pyemia0low10
Pyohemia0low10
Pyrexia0low20
Quadriparesis0low10
Quadriplegia0low10
Radiation Injuries, Experimental0low10
Reactive Hyperemia0low30
Research-Related Injuries0low10
Respiratory Acidosis0low10
Respiratory Depression0low20
Respiratory Failure0low20
Respiratory Insufficiency0low20
Rheumatoid Arthritis0low10
Ricker Syndrome0low10
Right-Sided Heart Failure0low40
Rigidity, Decerebrate0low40
Rigidity, Decorticate0low40
Salmonella typhi Infection0low10
Sarcoma 1800low10
Sarcoma 180, Crocker0low10
Schizophrenia0low10
Schizophrenic Disorders0low10
Schwartzman Phenomenon0low20
Schwartzman Reaction0low20
Sea Sickness0low10
Seasickness0low10
Secondary Myocardial Diseases0low10
Secondary Open Angle Glaucoma0low10
Seizure0low40
Seizure Disorder0low10
Seizures0low40
Seizures, Auditory0low40
Seizures, Clonic0low40
Seizures, Convulsive0low40
Seizures, Epileptic0low40
Seizures, Focal0low40
Seizures, Generalized0low40
Seizures, Gustatory0low40
Seizures, Motor0low40
Seizures, Olfactory0low40
Seizures, Sensory0low40
Seizures, Somatosensory0low40
Seizures, Tonic0low40
Seizures, Tonic-Clonic0low40
Seizures, Vertiginous0low40
Seizures, Vestibular0low40
Seizures, Visual0low40
Sensitivity and Specificity0low10
Sepsis0low10
Septic Shock0low30
Septicemia0low10
Severe Sepsis0low10
Shock0low70
Shock, Anaphylactic0low60
Shock, Endotoxic0low30
Shock, Hemorrhagic0low60
Shock, Septic0low30
Shock, Toxic0low30
Shock, Traumatic0low20
Shwartzman Phenomenon0low20
Shwartzman Reaction0low20
Single Seizure0low40
Skin Manifestations0low10
Soft Tissue Injuries0low10
Spastic Quadriplegia0low10
Spastic Tetraplegia0low10
Spinal Cord Contusion0low10
Spinal Cord Diseases0low10
Spinal Cord Disorders0low10
Spinal Cord Injuries0low10
Spinal Cord Laceration0low10
Spinal Cord Transection0low10
Spinal Cord Trauma0low10
Staphylococcal Infections0low20
Staphylococcus aureus Infection0low20
Steinert Disease0low10
Steinert Myotonic Dystrophy0low10
Steinert's Disease0low10
Stomach Fistula0low10
Stomach Ulcer0low50
Streptococcal Infections0low10
Streptozocin Diabetes0low10
Streptozotocin Diabetes0low10
Substance Abuse0low10
Substance Addiction0low10
Substance Dependence0low10
Substance Use0low10
Substance Use Disorders0low10
Substance-Induced Psychoses0low20
Substance-Related Disorders0low10
Suffering, Physical0low10
Susceptibility, Genetic0low10
Symptom Cluster0low10
Syndrome0low10
Tetraplegia0low10
Thrombosis0low40
Thrombus0low40
Tonic Clonic Seizure0low40
Tonic Seizure0low40
Tonic Seizures0low40
Tonic-Clonic Seizure0low40
Tonic-Clonic Seizures0low40
Toxic Hepatitis0low30
Toxic Psychoses0low20
Toxic Shock0low30
Toxic Shock Syndrome0low30
Trauma0low10
Tropical Eosinophilia0low10
Trypanosomiasis, Cardiovascular0low20
Tuberculin-Type Hypersensitivity0low10
Tubulointerstitial Nephritis0low10
Tumors0low40
Type I Hypersensitivity0low10
Type IV Hypersensitivity0low10
Typhoid0low10
Typhoid Fever0low10
Typhus, Abdominal0low10
Vascular Diseases0low30
Vascular Diseases, Peripheral0low30
Vascular Hypotension0low30
Venous Congestion0low30
Venous Engorgement0low30
Ventilatory Depression0low20
Ventricular Fibrillation0low30
Vitamin C Deficiency0low10
Water Stress0low10
Wet Lung0low40
Wounds0low10
Wounds and Injuries0low10
Wounds and Injury0low10
Wounds, Injury0low10

Research Highlights

Dosage (8)

ArticleYear
Discrimination by SZL49 between contractions evoked by noradrenaline in longitudinal and circular muscle of human vas deferens.
British journal of pharmacology, Volume: 136, Issue: 1		2002
Calculation of agonist efficacy, apparent affinity, and receptor population changes after administration of insurmountable antagonists: comparison of different analytical approaches.
Journal of pharmacological and toxicological methods, Volume: 35, Issue: 4		1996
Irreversible blockade of responses to a partial agonist acting at the histamine H1-receptor.
European journal of pharmacology, Jan-22, Volume: 77, Issue: 2-3		1982
Beta-carbolines selectively antagonize the cholecystokinin action in isolated guinea-pig gallbladder muscle.
Japanese journal of pharmacology, Volume: 42, Issue: 4		1986
Relationship between alpha-adrenoceptor occupancy and contractile response in rat vas deferens. Experimental and theoretical analysis.
European journal of pharmacology, Nov-08, Volume: 156, Issue: 3		1988
Purification of histamine receptor (VI). An improved double labeling method with "double protection".
Japanese journal of pharmacology, Volume: 27, Issue: 6		1977
Selective alpha-adrenoceptor blocking actions of a new derivative of 2-halogenotheylamine: 6-(2-bromoethyl)-10,11-methylenedioxy-5,6,7,8-tetrahydrodibenz[c,e]azocine.
Japanese journal of pharmacology, Volume: 26, Issue: 5		1976
Studies on the mode of antagonism between adrenergic beta-mimetics and beta-blocking agents (III). Functional antagonism between beta-mimetics and spasmogens.
Japanese journal of pharmacology, Volume: 26, Issue: 3		1976
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]