furanone c-30

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Description

furanone C-30: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	10131246
CHEMBL ID	1253219
SCHEMBL ID	1960492
MeSH ID	M0478045

Synonyms (22)

Synonym
(5z)-4-bromo-5-(bromomethylidene)furan-2-one
CHEMBL1253219
2(5h)-furanone, 4-bromo-5-(bromomethylene)-, (5z)-
furanone c-30
247167-54-0
(z)-4-bromo-5-(bromomethylene)furan-2(5h)-one
DPGLBHQUHFJRJS-RQOWECAXSA-N
4-bromo-5-(bromomethylene)-2(5h)-furanone
SCHEMBL1960492
furanone c30
32323-47-0
mfcd16875408
(z-)-4-bromo-5-(bromomethylene)-2(5h)-furanone, >=97.0% (gc)
(5z)-4-bromo-5-(bromomethylidene)-2,5-dihydrofuran-2-one
AS-68636
(5z)-4-bromo-5-(bromomethylene)-2(5h)-furanone
4-bromo-5-(bromomethylene)furan-2(5h)-one
AKOS037646413
CS-0120371
HY-131011
XJA16754
E89213

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (59)

Assay ID	Title	Year	Journal	Article
AID1595266	Inhibition of biofilm formation in Salmonella enterica subsp. enterica serovar Typhimurium 14028S incubated for 48 hrs by crystal violet staining based assay	2019	European journal of medicinal chemistry, Jun-01, Volume: 171	Insights into the chemistry and therapeutic potential of furanones: A versatile pharmacophore.
AID1237303	Inhibition of LasR in Pseudomonas aeruginosa PA14 assessed as reduction in biofilm formation at 1 to 1000 uM incubated at 37 degC for 24 hrs by crystal violet staining based static biofilm formation assay	2015	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15	Design, synthesis and biological evaluation of 4-(alkyloxy)-6-methyl-2H-pyran-2-one derivatives as quorum sensing inhibitors.
AID1453680	Inhibition of NFkappaB p65 subunit expression in nuclear fractions of human L428 cells at 2.5 ug/ml after 2 hrs by Western method	2017	Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13	Quorum sensing modulators exhibit cytotoxicity in Hodgkin's lymphoma cells and interfere with NF-κB signaling.
AID1507811	Inhibition of Fusobacterium nucleatum AI-2-mediated biofilm formation of Porphyromonas gingivalis ATCC 33277 assessed as biofilm formation at 2 uM incubated for 48 hrs under anaerobic condition by crystal violet staining-based assay (Rvb = 100%)	2017	European journal of medicinal chemistry, Sep-08, Volume: 137	New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation.
AID1453682	Inhibition of NFkappaB p50 subunit expression in cytosolic fractions of human L428 cells at 2.5 ug/ml after 2 hrs by Western method	2017	Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13	Quorum sensing modulators exhibit cytotoxicity in Hodgkin's lymphoma cells and interfere with NF-κB signaling.
AID1453676	Anti-migratory activity against human A549 cells assessed as reduction in wound closure at 7.94 uM after 48 hrs by wound-scratch assay	2017	Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13	Quorum sensing modulators exhibit cytotoxicity in Hodgkin's lymphoma cells and interfere with NF-κB signaling.
AID1453673	Inhibition of NF-kappaB (unknown origin) expressed in human L428 cells after 2 hrs by luciferase reporter gene assay	2017	Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13	Quorum sensing modulators exhibit cytotoxicity in Hodgkin's lymphoma cells and interfere with NF-κB signaling.
AID1453674	Cytotoxicity against human L428 cells after 24 by XTT assay	2017	Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13	Quorum sensing modulators exhibit cytotoxicity in Hodgkin's lymphoma cells and interfere with NF-κB signaling.
AID1278577	Antibacterial activity against clinical isolates of Pseudomonas aeruginosa PAOA assessed as inhibition of rhamnolipid secretion at 32 ug/ml	2016	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5	New antibacterial isocoumarin glycosides from a wetland soil derived fungal strain Metarhizium anisopliae.
AID1278574	Antibiofilm activity against clinical isolates of Pseudomonas aeruginosa PAOA at 16 to 64 ug/ml incubated for 20 hrs by crystal violet staining based spectrophotometric analysis	2016	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5	New antibacterial isocoumarin glycosides from a wetland soil derived fungal strain Metarhizium anisopliae.
AID1453675	Cytotoxicity against human L428 cells after 48 by XTT assay	2017	Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13	Quorum sensing modulators exhibit cytotoxicity in Hodgkin's lymphoma cells and interfere with NF-κB signaling.
AID1507799	Inhibition of Fusobacterium nucleatum AI-2-mediated biofilm formation of Porphyromonas gingivalis ATCC 33277 assessed as biofilm biomass at 2 uM incubated for 48 hrs under anaerobic condition by confocal laser scanning microscopic method (Rvb = 3.73 um'3/	2017	European journal of medicinal chemistry, Sep-08, Volume: 137	New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation.
AID1507821	Effect on host cell immune response in human THP1 cells assessed as upregulation of IL-6 mRNA expression at 2 uM after 24 hrs by RT-PCR method	2017	European journal of medicinal chemistry, Sep-08, Volume: 137	New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation.
AID1066995	Toxicity in Pseudomonas aeruginosa PAO1 assessed as planktonic growth inhibition at 400 uM after 24 hrs	2014	Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4	Bicyclic brominated furanones: a new class of quorum sensing modulators that inhibit bacterial biofilm formation.
AID1507803	Inhibition of Fusobacterium nucleatum AI-2-mediated biofilm formation of Fusobacterium nucleatum ATCC 25586 assessed as biofilm formation at 0.002 uM incubated for 48 hrs under anaerobic condition by crystal violet staining-based assay (Rvb = 100%)	2017	European journal of medicinal chemistry, Sep-08, Volume: 137	New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation.
AID1524867	Toxicity in Pseudomonas aeruginosa MH602 PlasB::gfp assessed as inhibition of bacterial growth at 62.5 uM incubated for 15 hrs by spectrophotometry	2019	Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9	Dihydropyrrolones as bacterial quorum sensing inhibitors.
AID1617931	Inhibition of quorum sensing in C6-HSL-induced Chromobacterium violaceum CV026 assessed as inhibition of bacterial growth by measuring minimum inhibitory dose per well after 18 hrs by well diffusion method	2019	Journal of natural products, 12-27, Volume: 82, Issue:12	Quinazoline-Containing Indole Alkaloids from the Marine-Derived Fungus
AID1278573	Antibacterial activity against clinical isolates of Pseudomonas aeruginosa PAOA incubated for 20 hrs by two fold dilution method	2016	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5	New antibacterial isocoumarin glycosides from a wetland soil derived fungal strain Metarhizium anisopliae.
AID1067001	Antibacterial activity against Pseudomonas aeruginosa PAO1 expressing green fluorescence protein assessed as inhibition of biofilm formation at 400 uM after 24 hrs by confocal laser scanning microscopic analysis	2014	Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4	Bicyclic brominated furanones: a new class of quorum sensing modulators that inhibit bacterial biofilm formation.
AID1351152	Inhibition of Pseudomonas aeruginosa PAO1 GFP-fused quorum sensing lasB at 10 uM measured every 15 mins up to 12 hrs by GFP reporter gene assay relative to control	2018	European journal of medicinal chemistry, Jan-20, Volume: 144	4-arylamidobenzyl substituted 5-bromomethylene-2(5H)-furanones for chronic bacterial infection.
AID1453679	Inhibition of NFkappaB p50 subunit expression in nuclear fractions of human L428 cells at 2.5 ug/ml after 2 hrs by Western method	2017	Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13	Quorum sensing modulators exhibit cytotoxicity in Hodgkin's lymphoma cells and interfere with NF-κB signaling.
AID1507810	Inhibition of Fusobacterium nucleatum AI-2-mediated biofilm formation of Porphyromonas gingivalis ATCC 33277 assessed as biofilm formation at 0.2 uM incubated for 48 hrs under anaerobic condition by crystal violet staining-based assay (Rvb = 100%)	2017	European journal of medicinal chemistry, Sep-08, Volume: 137	New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation.
AID1524866	Toxicity in Pseudomonas aeruginosa MH602 PlasB::gfp assessed as inhibition of bacterial growth at 125 uM incubated for 15 hrs by spectrophotometry	2019	Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9	Dihydropyrrolones as bacterial quorum sensing inhibitors.
AID514001	Antimicrobial activity against wild type Vibrio harveyi BB120	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Structure-activity relationship of brominated 3-alkyl-5-methylene-2(5H)-furanones and alkylmaleic anhydrides as inhibitors of Salmonella biofilm formation and quorum sensing regulated bioluminescence in Vibrio harveyi.
AID1507824	Effect on host cell immune response in human gingival fibroblasts assessed as upregulation of IL-8 mRNA expression at 2 uM after 24 hrs by RT-PCR method	2017	European journal of medicinal chemistry, Sep-08, Volume: 137	New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation.
AID1351153	Inhibition of Pseudomonas aeruginosa PAO1 GFP-fused quorum sensing rhlA at 10 uM measured every 15 mins up to 12 hrs by GFP reporter gene assay relative to control	2018	European journal of medicinal chemistry, Jan-20, Volume: 144	4-arylamidobenzyl substituted 5-bromomethylene-2(5H)-furanones for chronic bacterial infection.
AID514000	Inhibition of quorum sensing regulated bioluminescence in wild type Vibrio harveyi BB120 after 5 hrs by luminescence assay	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	Structure-activity relationship of brominated 3-alkyl-5-methylene-2(5H)-furanones and alkylmaleic anhydrides as inhibitors of Salmonella biofilm formation and quorum sensing regulated bioluminescence in Vibrio harveyi.
AID1524862	Inhibition of quorum sensing system in Pseudomonas aeruginosa MH602 PlasB::gfp at 125 uM incubated for 15 hrs by GFP reporter gene assay	2019	Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9	Dihydropyrrolones as bacterial quorum sensing inhibitors.
AID1507805	Inhibition of Fusobacterium nucleatum AI-2-mediated biofilm formation of Fusobacterium nucleatum ATCC 25586 assessed as biofilm formation at 0.2 uM incubated for 48 hrs under anaerobic condition by crystal violet staining-based assay (Rvb = 100%)	2017	European journal of medicinal chemistry, Sep-08, Volume: 137	New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation.
AID1507813	Inhibition of Fusobacterium nucleatum AI-2-mediated biofilm formation of Tannerella forsythia ATCC 43037 assessed as biofilm formation at 0.02 uM incubated for 48 hrs under anaerobic condition by crystal violet staining-based assay (Rvb = 100%)	2017	European journal of medicinal chemistry, Sep-08, Volume: 137	New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation.
AID1507823	Effect on host cell immune response in human gingival fibroblasts assessed as upregulation of IL-6 mRNA expression at 2 uM after 24 hrs by RT-PCR method	2017	European journal of medicinal chemistry, Sep-08, Volume: 137	New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation.
AID1453684	Inhibition of NFkappaB RelB subunit expression in cytosolic fractions of human L428 cells at 2.5 ug/ml after 2 hrs by Western method	2017	Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13	Quorum sensing modulators exhibit cytotoxicity in Hodgkin's lymphoma cells and interfere with NF-κB signaling.
AID1507794	Inhibition of Fusobacterium nucleatum ATCC 25586 AI-2 assessed as decrease in biofilm formation at 0.02 to 0.2 uM	2017	European journal of medicinal chemistry, Sep-08, Volume: 137	New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation.
AID1524868	Toxicity in Pseudomonas aeruginosa MH602 PlasB::gfp assessed as inhibition of bacterial growth at 31.25 uM incubated for 15 hrs by spectrophotometry	2019	Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9	Dihydropyrrolones as bacterial quorum sensing inhibitors.
AID1524861	Inhibition of quorum sensing system in Pseudomonas aeruginosa MH602 PlasB::gfp at 250 uM incubated for 15 hrs by GFP reporter gene assay	2019	Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9	Dihydropyrrolones as bacterial quorum sensing inhibitors.
AID1507806	Inhibition of Fusobacterium nucleatum AI-2-mediated biofilm formation of Fusobacterium nucleatum ATCC 25586 assessed as biofilm formation at 2 uM incubated for 48 hrs under anaerobic condition by crystal violet staining-based assay (Rvb = 100%)	2017	European journal of medicinal chemistry, Sep-08, Volume: 137	New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation.
AID1519590	Inhibition of pyoverdin production in Pseudomonas aeruginosa at 10 uM relative to control	2020	European journal of medicinal chemistry, Jan-01, Volume: 185	Design, synthesis, and evaluation of compounds capable of reducing Pseudomonas aeruginosa virulence.
AID1453681	Inhibition of NFkappaB RelB subunit expression in nuclear fractions of human L428 cells at 2.5 ug/ml after 2 hrs by Western method	2017	Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13	Quorum sensing modulators exhibit cytotoxicity in Hodgkin's lymphoma cells and interfere with NF-κB signaling.
AID1507815	Inhibition of Fusobacterium nucleatum AI-2-mediated biofilm formation of Tannerella forsythia ATCC 43037 assessed as biofilm formation at 2 uM incubated for 48 hrs under anaerobic condition by crystal violet staining-based assay (Rvb = 100%)	2017	European journal of medicinal chemistry, Sep-08, Volume: 137	New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation.
AID1524869	Inhibition of biofilm formation in Pseudomonas aeruginosa PAO1 at 250 uM incubated for 6 hrs by crystal violet staining based method	2019	Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9	Dihydropyrrolones as bacterial quorum sensing inhibitors.
AID1453683	Inhibition of NFkappaB p65 subunit expression in cytosolic fractions of human L428 cells at 2.5 ug/ml after 2 hrs by Western method	2017	Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13	Quorum sensing modulators exhibit cytotoxicity in Hodgkin's lymphoma cells and interfere with NF-κB signaling.
AID1507800	Inhibition of Fusobacterium nucleatum AI-2-mediated biofilm formation of Porphyromonas gingivalis ATCC 33277 assessed as biofilm average depth at 2 uM incubated for 48 hrs under anaerobic condition by confocal laser scanning microscopic method (Rvb = 4.87	2017	European journal of medicinal chemistry, Sep-08, Volume: 137	New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation.
AID1507804	Inhibition of Fusobacterium nucleatum AI-2-mediated biofilm formation of Fusobacterium nucleatum ATCC 25586 assessed as biofilm formation at 0.02 uM incubated for 48 hrs under anaerobic condition by crystal violet staining-based assay (Rvb = 100%)	2017	European journal of medicinal chemistry, Sep-08, Volume: 137	New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation.
AID1507808	Inhibition of Fusobacterium nucleatum AI-2-mediated biofilm formation of Porphyromonas gingivalis ATCC 33277 assessed as biofilm formation at 0.002 uM incubated for 48 hrs under anaerobic condition by crystal violet staining-based assay (Rvb = 100%)	2017	European journal of medicinal chemistry, Sep-08, Volume: 137	New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation.
AID1524864	Inhibition of quorum sensing system in Pseudomonas aeruginosa MH602 PlasB::gfp at 31.25 uM incubated for 15 hrs by GFP reporter gene assay	2019	Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9	Dihydropyrrolones as bacterial quorum sensing inhibitors.
AID1557219	Antibiofilm activity against 24 hrs-old biofilm of Streptococcus mutans assessed as reduction in cell viability relative to control	2019	MedChemComm, Jul-01, Volume: 10, Issue:7	Targeting
AID1507809	Inhibition of Fusobacterium nucleatum AI-2-mediated biofilm formation of Porphyromonas gingivalis ATCC 33277 assessed as biofilm formation at 0.02 uM incubated for 48 hrs under anaerobic condition by crystal violet staining-based assay (Rvb = 100%)	2017	European journal of medicinal chemistry, Sep-08, Volume: 137	New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation.
AID1507822	Effect on host cell immune response in human THP1 cells assessed as upregulation of IL-8 mRNA expression at 2 uM after 24 hrs by RT-PCR method	2017	European journal of medicinal chemistry, Sep-08, Volume: 137	New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation.
AID1507797	Inhibition of Fusobacterium nucleatum AI-2-mediated biofilm formation of Fusobacterium nucleatum ATCC 25586 assessed as biofilm biomass at 2 uM incubated for 48 hrs under anaerobic condition by confocal laser scanning microscopic method (Rvb = 2.99 um'3/u	2017	European journal of medicinal chemistry, Sep-08, Volume: 137	New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation.
AID1507812	Inhibition of Fusobacterium nucleatum AI-2-mediated biofilm formation of Tannerella forsythia ATCC 43037 assessed as biofilm formation at 0.002 uM incubated for 48 hrs under anaerobic condition by crystal violet staining-based assay (Rvb = 100%)	2017	European journal of medicinal chemistry, Sep-08, Volume: 137	New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation.
AID1507798	Inhibition of Fusobacterium nucleatum AI-2-mediated biofilm formation of Fusobacterium nucleatum ATCC 25586 assessed as biofilm average depth at 2 uM incubated for 48 hrs under anaerobic condition by confocal laser scanning microscopic method (Rvb = 5.37	2017	European journal of medicinal chemistry, Sep-08, Volume: 137	New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation.
AID1507802	Inhibition of Fusobacterium nucleatum AI-2-mediated biofilm formation of Tannerella forsythia ATCC 43037 assessed as biofilm average depth at 2 uM incubated for 48 hrs under anaerobic condition by confocal laser scanning microscopic method (Rvb = 5.29 um)	2017	European journal of medicinal chemistry, Sep-08, Volume: 137	New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation.
AID1507795	Inhibition of Fusobacterium nucleatum AI-2-mediated biofilm formation of Vibrio harveyi BB170 at 2 uM incubated for 6 hrs under aerobic condition by luciferase reporter gene assay	2017	European journal of medicinal chemistry, Sep-08, Volume: 137	New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation.
AID1524865	Toxicity in Pseudomonas aeruginosa MH602 PlasB::gfp assessed as inhibition of bacterial growth at 250 uM incubated for 15 hrs by spectrophotometry	2019	Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9	Dihydropyrrolones as bacterial quorum sensing inhibitors.
AID1507814	Inhibition of Fusobacterium nucleatum AI-2-mediated biofilm formation of Tannerella forsythia ATCC 43037 assessed as biofilm formation at 0.2 uM incubated for 48 hrs under anaerobic condition by crystal violet staining-based assay (Rvb = 100%)	2017	European journal of medicinal chemistry, Sep-08, Volume: 137	New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation.
AID1524863	Inhibition of quorum sensing system in Pseudomonas aeruginosa MH602 PlasB::gfp at 62.5 uM incubated for 15 hrs by GFP reporter gene assay	2019	Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9	Dihydropyrrolones as bacterial quorum sensing inhibitors.
AID1351154	Inhibition of Pseudomonas aeruginosa PAO1 GFP-fused quorum sensing pqsA at 10 uM measured every 15 mins up to 12 hrs by GFP reporter gene assay relative to control	2018	European journal of medicinal chemistry, Jan-20, Volume: 144	4-arylamidobenzyl substituted 5-bromomethylene-2(5H)-furanones for chronic bacterial infection.
AID1507801	Inhibition of Fusobacterium nucleatum AI-2-mediated biofilm formation of Tannerella forsythia ATCC 43037 assessed as biofilm biomass at 2 uM incubated for 48 hrs under anaerobic condition by confocal laser scanning microscopic method (Rvb = 4.05 um'3/um'2	2017	European journal of medicinal chemistry, Sep-08, Volume: 137	New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation.
AID1507796	Effect on Vibrio harveyi BB170 planktonic growth at 2 incubated for 48 hrs under anaerobic condition by spectrophotometric method	2017	European journal of medicinal chemistry, Sep-08, Volume: 137	New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (34)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (11.76)	29.6817
2010's	24 (70.59)	24.3611
2020's	6 (17.65)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.00

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	21.00 (24.57)
Research Supply Index	3.56 (2.92)
Research Growth Index	5.25 (4.65)
Search Engine Demand Index	18.60 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (21.00)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (5.88%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	32 (94.12%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
nickel Nickel: A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.. nickel ion : A nickel atom having a net electric charge.. nickel atom : Chemical element (nickel group element atom) with atomic number 28.	2.11	1	metal allergen; nickel group element atom	epitope; micronutrient
celecoxib [no description available]	3.31	1	organofluorine compound; pyrazoles; sulfonamide; toluenes	cyclooxygenase 2 inhibitor; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug
ciprofloxacin Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.	2.53	2	aminoquinoline; cyclopropanes; fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone; zwitterion	antibacterial drug; antiinfective agent; antimicrobial agent; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; environmental contaminant; topoisomerase IV inhibitor; xenobiotic
diclofenac Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.. diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.	3.31	1	amino acid; aromatic amine; dichlorobenzene; monocarboxylic acid; secondary amino compound	antipyretic; drug allergen; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic
emodin Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.. emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.	3.31	1	trihydroxyanthraquinone	antineoplastic agent; laxative; plant metabolite; tyrosine kinase inhibitor
fluorouracil Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.	7.08	1	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic
ibuprofen Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine	3.31	1	monocarboxylic acid	antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; environmental contaminant; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug; radical scavenger; xenobiotic
indomethacin Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.	2.17	1	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic
ofloxacin Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.. 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.. ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.	3.31	1	3-oxo monocarboxylic acid; N-arylpiperazine; N-methylpiperazine; organofluorine compound; oxazinoquinoline
patulin Patulin: 4-Hydroxy-4H-furo(3,2-c)pyran-2(6H)-one. A mycotoxin produced by several species of Aspergillus and Penicillium. It is found in unfermented apple and grape juice and field crops. It has antibiotic properties and has been shown to be carcinogenic and mutagenic and causes chromosome damage in biological systems.. patulin : A furopyran and lactone that is (2H-pyran-3(6H)-ylidene)acetic acid which is substituted by hydroxy groups at positions 2 and 4 and in which the hydroxy group at position 4 has condensed with the carboxy group to give the corresponding bicyclic lactone. A mycotoxin produced by several species of Aspergillus and Penicillium, it has antibiotic properties but has been shown to be carcinogenic and mutagenic.	2.03	1	furopyran; gamma-lactone; lactol	antimicrobial agent; Aspergillus metabolite; carcinogenic agent; mutagen; mycotoxin; Penicillium metabolite
rofecoxib [no description available]	3.31	1	butenolide; sulfone	analgesic; cyclooxygenase 2 inhibitor; non-steroidal anti-inflammatory drug
pyocyanine Pyocyanine: Antibiotic pigment produced by Pseudomonas aeruginosa.. pyocyanine : An iminium betaine that is 5-methylphenazin-5-ium which is substituted at position 1 by an oxidanidyl group. An antibiotic pigment produced by Pseudomonas aeruginosa.	3.04	4	iminium betaine; phenazines	antibacterial agent; bacterial metabolite; biological pigment; virulence factor
4-butyrolactone 4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.. tetrahydrofuranone : Any oxolane having an oxo- substituent at any position on the tetrahydrofuran ring.. gamma-butyrolactone : A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.	3.14	5	butan-4-olide	metabolite; neurotoxin
butyl methacrylate [no description available]	2.21	1	enoate ester
thiazoles [no description available]	2.07	1	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
4-nitropyridine 1-oxide [no description available]	2.03	1
durapatite Durapatite: The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.. hydroxylapatite : A phosphate mineral with the formula Ca5(PO4)3(OH).	2.21	1
zinc oxide Zinc Oxide: A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.	2.11	1	zinc molecular entity
titanium Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts with atomic number, 22, atomic weight, 47.867 and symbol, Ti; specific gravity, 4.5; used for fixation of fractures.	2.59	2	titanium group element atom
titanium dioxide titanium dioxide: used medically as protectant against externally caused irritation & sunlight; high concentrations of dust may cause irritation to respiratory tract; RN given refers to titanium oxide (TiO2); structure. titanium dioxide : A titanium oxide with the formula TiO2. A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications.	2.13	1	titanium oxides	food colouring
tobramycin Tobramycin: An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.. tobramycin : A amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring.	2.25	1	amino cyclitol glycoside	antibacterial agent; antimicrobial agent; toxin
thiazolyl blue thiazolyl blue: RN & II refers to bromide. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide : The bromide salt of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium.	2.07	1	organic bromide salt	colorimetric reagent; dye
epigallocatechin gallate epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis). (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.	3.31	1	flavans; gallate ester; polyphenol	antineoplastic agent; antioxidant; apoptosis inducer; geroprotector; Hsp90 inhibitor; neuroprotective agent; plant metabolite
rosiglitazone [no description available]	2.17	1	aminopyridine; thiazolidinediones	EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor; ferroptosis inhibitor; insulin-sensitizing drug
tryptoquivaline tryptoquivaline: tremor-producing metabolite from Aspergillus clavatus; tetrapeptide derived from tryptophan, anthranilic acid, valine, & methylalanine; structure & N1 names previously assigned to tryptoquivaline C & tryptoquivaline D found to be incorrect & are revised in third source; see also record for tryptoquivalone; structure in third source	2.21	1
3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2(5h)-furanone 3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2(5H)-furanone: structure given in first source	3.31	1
arbutin hydroquinone O-beta-D-glucopyranoside : A monosaccharide derivative that is hydroquinone attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage.	3.31	1	beta-D-glucoside; monosaccharide derivative	Escherichia coli metabolite; plant metabolite
meropenem Meropenem: A thienamycin derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of bacterial infections, including infections in immunocompromised patients.. meropenem : A carbapenemcarboxylic acid in which the azetidine and pyrroline rings carry 1-hydroxymethyl and in which the azetidine and pyrroline rings carry 1-hydroxymethyl and 5-(dimethylcarbamoyl)pyrrolidin-3-ylthio substituents respectively.	2.25	1	alpha,beta-unsaturated monocarboxylic acid; carbapenemcarboxylic acid; organic sulfide; pyrrolidinecarboxamide	antibacterial agent; antibacterial drug; drug allergen
resveratrol trans-resveratrol : A resveratrol in which the double bond has E configuration.	3.31	1	resveratrol	antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger
ketoconazole (2R,4S)-ketoconazole : A cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine which dioxolane moiety has (2R,4S)-configuration.	3.31	1	cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine
chalcone trans-chalcone : The trans-isomer of chalcone.	3.31	1	chalcone	EC 3.2.1.1 (alpha-amylase) inhibitor
gw9662 2-chloro-5-nitrobenzanilide: pretreatment of peroxisome proliferator activated receptors with GW9662 results in the irreversible loss of ligand binding	2.17	1	benzamides
3,3',4,5'-tetrahydroxystilbene 3,3',4,5'-tetrahydroxystilbene: demethyl derivative of isorhapontigenin; structure in first source; a Syk kinase inhibitor; found in heartwood of FABACEAE; inhibitor of photosynthesis in spinach chloroplasts; may be inhibitor of plant growth; RN given refers to (E)-isomer. piceatannol : A stilbenol that is trans-stilbene in which one of the phenyl groups is substituted by hydroxy groups at positions 3 and 4, while the other phenyl group is substituted by hydroxy groups at positions 3 and 5.	3.31	1	catechols; polyphenol; resorcinols; stilbenol	antineoplastic agent; apoptosis inducer; geroprotector; hypoglycemic agent; plant metabolite; protein kinase inhibitor; tyrosine kinase inhibitor
curcumin Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.. curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.	3.68	2	aromatic ether; beta-diketone; diarylheptanoid; enone; polyphenol	anti-inflammatory agent; antifungal agent; antineoplastic agent; biological pigment; contraceptive drug; dye; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor; EC 1.8.1.9 (thioredoxin reductase) inhibitor; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; flavouring agent; food colouring; geroprotector; hepatoprotective agent; immunomodulator; iron chelator; ligand; lipoxygenase inhibitor; metabolite; neuroprotective agent; nutraceutical; radical scavenger
penicillic acid Penicillic Acid: A mycotoxin with antibiotic and carcinogenic activity produced by various strains of PENICILLIUM and ASPERGILLUS. It has been found in tobacco, sausages, and corn.	2.03	1
2-heptyl-3-hydroxy-4-quinolone 2-heptyl-3-hydroxy-4-quinolone: structure in first source. 2-heptyl-3-hydroxy-4-quinolone : A quinolone consisting of quinolin-4(1H)-one carrying a heptyl substituent at position 2 and a hydroxy group at position 3.	2.15	1	quinolone	signalling molecule
n-(3-oxododecanoyl)homoserine lactone N-(3-oxododecanoyl)-L-homoserine lactone : An N-acyl-L-homoserine lactone having 3-oxododecanoyl as the acyl substituent.	2.15	1	N-(3-oxododecanoyl)homoserine lactone; N-acyl-L-homoserine lactone	bacterial metabolite
homoserine lactone homoserine lactone: a putative signal for starvation in E. coli; structure in first source. homoserinium lactone : The conjugate acid of homoserine lactone; major species at pH 7.3.. homoserine lactone : A butan-4-olide having an amino substituent at the 2-position.	3.14	5	ammonium ion derivative; organic cation
4-hydroxy-5-methyl-3(2h)-furanone 4-hydroxy-5-methyl-3-furanone : A member of the class of furans that is 5-methyl-2,3-dihydrofuran with a hydroxy group at position 4 and a keto group at position 3.	3.31	1	cyclic ketone; enol; furans	metabolite
amphotericin b Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.	3.31	1	antibiotic antifungal drug; macrolide antibiotic; polyene antibiotic	antiamoebic agent; antiprotozoal drug; bacterial metabolite
morin morin: a light yellowish pigment found in the wood of old fustic (Chlorophora tinctoria). morin : A pentahydroxyflavone that is 7-hydroxyflavonol bearing three additional hydroxy substituents at positions 2' 4' and 5.	3.31	1	7-hydroxyflavonol; pentahydroxyflavone	angiogenesis modulating agent; anti-inflammatory agent; antibacterial agent; antihypertensive agent; antineoplastic agent; antioxidant; EC 5.99.1.2 (DNA topoisomerase) inhibitor; hepatoprotective agent; metabolite; neuroprotective agent
gallium Gallium: A rare, metallic element designated by the symbol, Ga, atomic number 31, and atomic weight 69.72.. gallium atom : A metallic element predicted as eka-aluminium by Mendeleev in 1870 and discovered by Paul-Emile Lecoq de Boisbaudran in 1875. Named in honour of France (Latin Gallia) and perhaps also from the Latin gallus cock, a translation of Lecoq.	2.57	2	boron group element atom
(5z)-4-bromo-5-(bromomethylene)-3-butyl-2(5h)-furanone 4-bromo-5Z-(bromomethylene)-3-butylfuran-2-one: structure in first source	3.61	2
colistin Colistin: Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.. colistin : A multi-component mixture comprising mostly of colistin A (R = Me) and B (R = H), with small amounts of colistin C and other polymyxins, produced by certain strains of Bacillus polymyxa var. colistinus. An antibiotic, it is used as its sulfate salt (for oral or topical use) or as the sodium salt of the N-methylsulfonic acid derivative (the injectable form) in the treatment of severe Gram-negative infections, partiularly those due to Pseudomonas aeruginosa.	2.25	1
ascorbic acid Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.	3.31	1	ascorbic acid; vitamin C	coenzyme; cofactor; flour treatment agent; food antioxidant; food colour retention agent; geroprotector; plant metabolite; skin lightening agent
carolacton carolacton: damages biofilms; isolated from Sorangium cellulosum; structure in first source	3.31	1	terpene lactone
agar Agar: A complex sulfated polymer of galactose units, extracted from Gelidium cartilagineum, Gracilaria confervoides, and related red algae. It is used as a gel in the preparation of solid culture media for microorganisms, as a bulk laxative, in making emulsions, and as a supporting medium for immunodiffusion and immunoelectrophoresis.. agar : A complex mixture of polysaccharides extracted from species of red algae. Its two main components are agarose and agaropectin. Agarose is the component responsible for the high-strength gelling properties of agar, while agaropectin provides the viscous properties.	2.07	1

Condition	Relationship Strength	Studies
Infections, Pseudomonas [description not available]	3.38	6
Pseudomonas Infections Infections with bacteria of the genus PSEUDOMONAS.	3.38	6
Granuloma, Hodgkin [description not available]	2.15	1
Hodgkin Disease A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.	2.15	1
Chronic Illness [description not available]	2.17	1
Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	2.17	1
Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.	2.31	1
Actinobacillus Infections Infections with bacteria of the genus ACTINOBACILLUS.	2.25	1
Cystic Fibrosis of Pancreas [description not available]	2.52	2
Infections, Respiratory [description not available]	2.11	1
Cystic Fibrosis An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.	7.52	2
Respiratory Tract Infections Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.	2.11	1
Fish Diseases Diseases of freshwater, marine, hatchery or aquarium fish. This term includes diseases of both teleosts (true fish) and elasmobranchs (sharks, rays and skates).	2.02	1
Infections, Vibrio [description not available]	2.02	1
Infections, Yersinia [description not available]	2.03	1

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