Page last updated: 2024-08-07 15:24:36
Acetylcholinesterase
[no definition available]
Synonyms
AChE;
EC 3.1.1.7
Research
Bioassay Publications (403)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 5 (1.24) | 18.7374 |
| 1990's | 5 (1.24) | 18.2507 |
| 2000's | 35 (8.68) | 29.6817 |
| 2010's | 306 (75.93) | 24.3611 |
| 2020's | 52 (12.90) | 2.80 |
Compounds (131)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| hydroquinone | Electrophorus electricus (electric eel) | Ki | 0.0012 | 1 | 1 |
| palmitic acid | Electrophorus electricus (electric eel) | IC50 | 10.1500 | 1 | 1 |
| 2-(4-methyl-1,3-thiazol-5-yl)ethanol | Electrophorus electricus (electric eel) | Ki | 4,669.0000 | 4 | 4 |
| methylbufotenin | Electrophorus electricus (electric eel) | IC50 | 14.0000 | 1 | 1 |
| 6-methoxytryptoline | Electrophorus electricus (electric eel) | IC50 | 227.0300 | 1 | 1 |
| tacrine | Electrophorus electricus (electric eel) | IC50 | 2.9254 | 156 | 170 |
| tacrine | Electrophorus electricus (electric eel) | Ki | 0.0764 | 6 | 6 |
| berberine | Electrophorus electricus (electric eel) | IC50 | 0.7827 | 3 | 3 |
| donepezil | Electrophorus electricus (electric eel) | IC50 | 0.8037 | 142 | 153 |
| donepezil | Electrophorus electricus (electric eel) | Ki | 0.0287 | 4 | 4 |
| ebselen | Electrophorus electricus (electric eel) | IC50 | 28.0050 | 2 | 2 |
| econazole | Electrophorus electricus (electric eel) | IC50 | 22.3000 | 1 | 1 |
| gallamine triethiodide | Electrophorus electricus (electric eel) | IC50 | 3,150.0000 | 1 | 1 |
| harmaline | Electrophorus electricus (electric eel) | IC50 | 4.9000 | 1 | 1 |
| harmalol | Electrophorus electricus (electric eel) | IC50 | 11.2800 | 1 | 1 |
| ketamine | Electrophorus electricus (electric eel) | IC50 | 10.0000 | 1 | 1 |
| memantine | Electrophorus electricus (electric eel) | IC50 | 10.0000 | 1 | 1 |
| miconazole | Electrophorus electricus (electric eel) | IC50 | 11.9000 | 2 | 2 |
| minaprine | Electrophorus electricus (electric eel) | IC50 | 600.0000 | 1 | 1 |
| clorgyline | Electrophorus electricus (electric eel) | IC50 | 500.0000 | 1 | 1 |
| neostigmine | Electrophorus electricus (electric eel) | IC50 | 24.5800 | 9 | 14 |
| stearic acid | Electrophorus electricus (electric eel) | IC50 | 7.5000 | 1 | 1 |
| stearic acid | Electrophorus electricus (electric eel) | Ki | 4.0100 | 2 | 2 |
| tetraisopropylpyrophosphamide | Electrophorus electricus (electric eel) | IC50 | 51.2500 | 2 | 2 |
| donepezil hydrochloride | Electrophorus electricus (electric eel) | IC50 | 0.0709 | 8 | 8 |
| neostigmine methylsulfate | Electrophorus electricus (electric eel) | IC50 | 23.5500 | 2 | 2 |
| isoflurophate | Electrophorus electricus (electric eel) | IC50 | 0.4800 | 1 | 1 |
| serine | Electrophorus electricus (electric eel) | IC50 | 0.0150 | 1 | 1 |
| physostigmine | Electrophorus electricus (electric eel) | IC50 | 3.1018 | 16 | 18 |
| physostigmine | Electrophorus electricus (electric eel) | Ki | 0.0340 | 1 | 1 |
| thiamine | Electrophorus electricus (electric eel) | Ki | 430.5000 | 4 | 4 |
| carbaryl | Electrophorus electricus (electric eel) | IC50 | 3.1000 | 1 | 1 |
| ficusin | Electrophorus electricus (electric eel) | IC50 | 29.5000 | 1 | 1 |
| thymol | Electrophorus electricus (electric eel) | IC50 | 458.2300 | 1 | 1 |
| isatin | Electrophorus electricus (electric eel) | IC50 | 1,000.0000 | 1 | 1 |
| neostigmine bromide | Electrophorus electricus (electric eel) | IC50 | 0.0594 | 4 | 4 |
| thiamine pyrophosphate | Electrophorus electricus (electric eel) | Ki | 23,485.0000 | 4 | 4 |
| galantamine | Electrophorus electricus (electric eel) | IC50 | 3.6610 | 82 | 96 |
| galantamine | Electrophorus electricus (electric eel) | Ki | 1.2976 | 5 | 5 |
| benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(n,n-dimethyl-n-2-propenyl-), dibromide | Electrophorus electricus (electric eel) | IC50 | 0.0365 | 2 | 2 |
| glycyrrhetinic acid | Electrophorus electricus (electric eel) | Ki | 100.0000 | 1 | 1 |
| liriodenine | Electrophorus electricus (electric eel) | IC50 | 150.0000 | 1 | 1 |
| bufotenin | Electrophorus electricus (electric eel) | IC50 | 11.4000 | 1 | 1 |
| carvacrol | Electrophorus electricus (electric eel) | IC50 | 288.2600 | 1 | 1 |
| arachidic acid | Electrophorus electricus (electric eel) | IC50 | 12.8000 | 1 | 1 |
| angelicin | Electrophorus electricus (electric eel) | IC50 | 25.4000 | 1 | 1 |
| thiamine monophosphate | Electrophorus electricus (electric eel) | Ki | 7,377.5000 | 4 | 4 |
| Berberine chloride (TN) | Electrophorus electricus (electric eel) | IC50 | 0.7120 | 7 | 7 |
| Berberine chloride (TN) | Electrophorus electricus (electric eel) | Ki | 0.2890 | 1 | 1 |
| 4-methylthiazole | Electrophorus electricus (electric eel) | Ki | 30,935.0000 | 4 | 4 |
| 3-hydroxyphenyltrimethylammonium | Electrophorus electricus (electric eel) | IC50 | 0.9730 | 1 | 1 |
| selegiline | Electrophorus electricus (electric eel) | IC50 | 500.0000 | 1 | 1 |
| bambuterol | Electrophorus electricus (electric eel) | IC50 | 100.0000 | 1 | 1 |
| platanic acid | Electrophorus electricus (electric eel) | Ki | 34.2500 | 2 | 2 |
| rutecarpine | Electrophorus electricus (electric eel) | IC50 | 100.0000 | 2 | 2 |
| isoimperatorin | Electrophorus electricus (electric eel) | IC50 | 25.6000 | 1 | 1 |
| 2,3-trimethylene-4-quinazolone | Electrophorus electricus (electric eel) | IC50 | 24.0000 | 2 | 2 |
| 4-aminopyrimidine | Electrophorus electricus (electric eel) | Ki | 6,957.5000 | 4 | 4 |
| avarol | Electrophorus electricus (electric eel) | IC50 | 285.6300 | 1 | 1 |
| chelerythrine chloride | Electrophorus electricus (electric eel) | IC50 | 3.7800 | 1 | 1 |
| chelerythrine chloride | Electrophorus electricus (electric eel) | Ki | 0.7000 | 2 | 2 |
| lycorine | Electrophorus electricus (electric eel) | IC50 | 200.0000 | 1 | 1 |
| voacamine | Electrophorus electricus (electric eel) | IC50 | 4.4000 | 1 | 1 |
| maslinic acid | Electrophorus electricus (electric eel) | Ki | 100.0000 | 1 | 1 |
| rivastigmine | Electrophorus electricus (electric eel) | IC50 | 45.8867 | 36 | 41 |
| propidium iodide | Electrophorus electricus (electric eel) | Ki | 8.1000 | 2 | 3 |
| beta-carboline-3-carboxylic acid methyl ester | Electrophorus electricus (electric eel) | IC50 | 63.0000 | 1 | 1 |
| tryptoline | Electrophorus electricus (electric eel) | IC50 | 97.0800 | 1 | 1 |
| bifendate | Electrophorus electricus (electric eel) | IC50 | 50.0000 | 1 | 1 |
| territrem b | Electrophorus electricus (electric eel) | IC50 | 0.2600 | 2 | 2 |
| liquiritigenin | Electrophorus electricus (electric eel) | IC50 | 9.1000 | 1 | 1 |
| razadyne | Electrophorus electricus (electric eel) | IC50 | 0.6675 | 4 | 4 |
| razadyne | Electrophorus electricus (electric eel) | Ki | 0.4767 | 9 | 9 |
| lysicamine | Electrophorus electricus (electric eel) | IC50 | 16.1000 | 1 | 1 |
| glabranin | Electrophorus electricus (electric eel) | IC50 | 23.0000 | 1 | 1 |
| tetrahydrocurcumin | Electrophorus electricus (electric eel) | IC50 | 41.1600 | 1 | 1 |
| evodiamine | Electrophorus electricus (electric eel) | IC50 | 10.0000 | 1 | 1 |
| asimilobine | Electrophorus electricus (electric eel) | IC50 | 100.0000 | 1 | 1 |
| nantenine, (+-)-isomer | Electrophorus electricus (electric eel) | IC50 | 1.0900 | 1 | 1 |
| phenserine | Electrophorus electricus (electric eel) | IC50 | 0.3500 | 1 | 1 |
| tv3326 | Electrophorus electricus (electric eel) | IC50 | 40.9000 | 2 | 2 |
| taspine | Electrophorus electricus (electric eel) | IC50 | 0.3300 | 1 | 1 |
| 2-(4-hydroxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one | Electrophorus electricus (electric eel) | IC50 | 100.0000 | 1 | 1 |
| naringenin | Electrophorus electricus (electric eel) | IC50 | 100.0000 | 1 | 1 |
| reticuline | Electrophorus electricus (electric eel) | IC50 | 301.0100 | 1 | 1 |
| pancracine | Electrophorus electricus (electric eel) | IC50 | 200.0000 | 1 | 1 |
| resveratrol | Electrophorus electricus (electric eel) | IC50 | 1,000.0000 | 1 | 1 |
| om99-2 | Electrophorus electricus (electric eel) | IC50 | 0.0140 | 1 | 1 |
| ferulic acid | Electrophorus electricus (electric eel) | IC50 | 100.0000 | 3 | 3 |
| cyclosaligenyl-2',3'-didehydro-2',3'-dideoxythymidine monophosphate | Electrophorus electricus (electric eel) | IC50 | 50.0000 | 1 | 1 |
| amiridine | Electrophorus electricus (electric eel) | IC50 | 0.1700 | 1 | 1 |
| cannabidiol | Electrophorus electricus (electric eel) | IC50 | 17.0700 | 1 | 1 |
| physostigmine salicylate | Electrophorus electricus (electric eel) | Ki | 0.2100 | 1 | 1 |
| 1-(4-amino-2-methyl-3-quinolinyl)ethanone | Electrophorus electricus (electric eel) | IC50 | 0.3200 | 1 | 1 |
| 2-amino-4-phenyl-6-(1-pyrrolidinyl)pyridine-3,5-dicarbonitrile | Electrophorus electricus (electric eel) | IC50 | 100.0000 | 1 | 1 |
| 4-amino-5-(pyridin-4-yl)-4h-1,2,4-triazole-3-thiol | Electrophorus electricus (electric eel) | IC50 | 13.4600 | 1 | 1 |
| huperzine a | Electrophorus electricus (electric eel) | IC50 | 8.0850 | 2 | 2 |
| curcumin | Electrophorus electricus (electric eel) | IC50 | 132.1300 | 2 | 2 |
| tacrine hydrochloride | Electrophorus electricus (electric eel) | IC50 | 0.0888 | 4 | 4 |
| bakuchicin | Electrophorus electricus (electric eel) | IC50 | 35.7000 | 1 | 1 |
| scopoletin | Electrophorus electricus (electric eel) | IC50 | 35.8000 | 1 | 1 |
| hymecromone | Electrophorus electricus (electric eel) | IC50 | 133.5000 | 2 | 2 |
| harmine | Electrophorus electricus (electric eel) | IC50 | 16.4950 | 2 | 2 |
| harman | Electrophorus electricus (electric eel) | IC50 | 20.9100 | 1 | 1 |
| 7-hydroxycoumarin | Electrophorus electricus (electric eel) | IC50 | 140.0000 | 1 | 1 |
| ellagic acid | Electrophorus electricus (electric eel) | IC50 | 132.9200 | 1 | 1 |
| 7-hydroxyflavone | Electrophorus electricus (electric eel) | IC50 | 85.0000 | 1 | 1 |
| oxycodone | Electrophorus electricus (electric eel) | IC50 | 76.2000 | 1 | 1 |
| morphine | Electrophorus electricus (electric eel) | Ki | 109.0000 | 1 | 1 |
| bisdemethoxycurcumin | Electrophorus electricus (electric eel) | IC50 | 18.2700 | 1 | 1 |
| 3,5-dimethoxy-trans-stilbene | Electrophorus electricus (electric eel) | IC50 | 9.0000 | 1 | 1 |
| osthenol | Electrophorus electricus (electric eel) | IC50 | 25.3000 | 1 | 1 |
| levorphanol | Electrophorus electricus (electric eel) | Ki | 25.0000 | 1 | 1 |
| levallorphan | Electrophorus electricus (electric eel) | Ki | 12.0000 | 1 | 1 |
| dextrorphan | Electrophorus electricus (electric eel) | Ki | 20.0000 | 1 | 1 |
| himbacine | Electrophorus electricus (electric eel) | IC50 | 22.7200 | 1 | 1 |
| ith 4012 | Electrophorus electricus (electric eel) | IC50 | 0.8155 | 4 | 4 |
| helicide | Electrophorus electricus (electric eel) | IC50 | 0.4500 | 1 | 1 |
| helicide | Electrophorus electricus (electric eel) | Ki | 0.7300 | 1 | 1 |
| bis(7)-tacrine | Electrophorus electricus (electric eel) | IC50 | 0.0007 | 3 | 3 |
| ap 2238 | Electrophorus electricus (electric eel) | IC50 | 0.0400 | 1 | 1 |
| memoquin | Electrophorus electricus (electric eel) | IC50 | 0.0067 | 1 | 1 |
| delta-viniferin | Electrophorus electricus (electric eel) | IC50 | 4.3000 | 1 | 1 |
| sargahydroquinoic acid | Electrophorus electricus (electric eel) | IC50 | 124.3000 | 1 | 1 |
| n-salicyloyltryptamine | Electrophorus electricus (electric eel) | IC50 | 23.1600 | 1 | 1 |
| 6-chlorotacrine | Electrophorus electricus (electric eel) | IC50 | 0.0510 | 2 | 2 |
| sargachromenol | Electrophorus electricus (electric eel) | IC50 | 97.3000 | 1 | 1 |
| montanine | Electrophorus electricus (electric eel) | IC50 | 200.0000 | 1 | 1 |
| 4-(4-Methoxyphenyl)-5,7-dihydroxychroman-2-one | Electrophorus electricus (electric eel) | IC50 | 50.0000 | 1 | 1 |
| augustic acid | Electrophorus electricus (electric eel) | Ki | 30.0000 | 1 | 1 |
| vobasine | Electrophorus electricus (electric eel) | IC50 | 1,000.0000 | 1 | 1 |
| voacristine | Electrophorus electricus (electric eel) | IC50 | 420.0000 | 1 | 1 |
| marinoquinoline a | Electrophorus electricus (electric eel) | IC50 | 3.6000 | 1 | 1 |
| ass234 | Electrophorus electricus (electric eel) | IC50 | 0.3500 | 3 | 3 |
| ass234 | Electrophorus electricus (electric eel) | Ki | 0.1490 | 1 | 1 |
| asoxime chloride | Electrophorus electricus (electric eel) | IC50 | 800.0000 | 1 | 1 |
| asoxime chloride | Electrophorus electricus (electric eel) | Ki | 228.8000 | 1 | 1 |
| pralidoxime chloride | Electrophorus electricus (electric eel) | IC50 | 292.5000 | 2 | 2 |
| pralidoxime chloride | Electrophorus electricus (electric eel) | Ki | 126.5000 | 1 | 1 |
| discorhabdin l | Electrophorus electricus (electric eel) | IC50 | 25.7000 | 1 | 1 |
| discorhabdin l | Electrophorus electricus (electric eel) | Ki | 15.0000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| tacrine | Electrophorus electricus (electric eel) | Kd | 0.0160 | 1 | 1 |
| soman | Electrophorus electricus (electric eel) | Kd | 0.5050 | 2 | 2 |
| sarin | Electrophorus electricus (electric eel) | Kd | 2.2000 | 1 | 1 |
| paraoxon | Electrophorus electricus (electric eel) | Kd | 170.0000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| physostigmine | Electrophorus electricus (electric eel) | K | 0.0343 | 1 | 1 |
| ellagic acid | Electrophorus electricus (electric eel) | EC24 | 250.0000 | 1 | 1 |
Development of 5-hydroxyl-1-azabenzanthrone derivatives as dual binding site and selective acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Apr-15, Volume: 234, 2022
Selective butyrylcholinesterase inhibition by isatin dimers and 3-indolyl-3-hydroxy-2-oxindole dimers.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 77, 2022
Design, synthesis, and biological evaluation of novel (4-(1,2,4-oxadiazol-5-yl)phenyl)-2-aminoacetamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jan-05, Volume: 227, 2022
Design, synthesis and biological evaluation of naringenin carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 10-01, Volume: 49, 2021
Design, synthesis and biological evaluation of novel deoxyvasicinone-indole as multi-target agents for Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 10-01, Volume: 49, 2021
Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HTEuropean journal of medicinal chemistry, , Dec-05, Volume: 225, 2021
ROS-responsive and multifunctional anti-Alzheimer prodrugs: Tacrine-ibuprofen hybrids via a phenyl boronate linker.European journal of medicinal chemistry, , Feb-15, Volume: 212, 2021
Discovery of multifunctional anti-Alzheimer's agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and γ-aminobutyric acid transporters.European journal of medicinal chemistry, , Jun-05, Volume: 218, 2021
A review on ferulic acid and analogs based scaffolds for the management of Alzheimer's disease.European journal of medicinal chemistry, , Apr-05, Volume: 215, 2021
Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy.Bioorganic & medicinal chemistry letters, , 02-01, Volume: 30, Issue:3, 2020
Rapid discovery of a selective butyrylcholinesterase inhibitor using structure-based virtual screening.Bioorganic & medicinal chemistry letters, , 12-15, Volume: 30, Issue:24, 2020
Discovery of 9-phenylacridinediones as highly selective butyrylcholinesterase inhibitors through structure-based virtual screening.Bioorganic & medicinal chemistry letters, , 05-01, Volume: 30, Issue:9, 2020
Bioactive Azepine-Indole Alkaloids from Journal of natural products, , 04-24, Volume: 83, Issue:4, 2020
1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Feb-01, Volume: 187, 2020
Design, synthesis and anti-Alzheimer's disease activity study of xanthone derivatives based on multi-target strategy.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 30, Issue:4, 2020
Search for new multi-target compounds against Alzheimer's disease among histamine HEuropean journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
Dual functional cholinesterase and PDE4D inhibitors for the treatment of Alzheimer's disease: Design, synthesis and evaluation of tacrine-pyrazolo[3,4-b]pyridine hybrids.Bioorganic & medicinal chemistry letters, , 08-15, Volume: 29, Issue:16, 2019
Triazole derivatives as inhibitors of Alzheimer's disease: Current developments and structure-activity relationships.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity.Bioorganic & medicinal chemistry letters, , 03-15, Volume: 29, Issue:6, 2019
Synthesis of novel vanillin derivatives: novel multi-targeted scaffold ligands against Alzheimer's disease.MedChemComm, , May-01, Volume: 10, Issue:5, 2019
Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands.MedChemComm, , Dec-01, Volume: 10, Issue:12, 2019
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.European journal of medicinal chemistry, , Apr-01, Volume: 167, 2019
Tacrines for Alzheimer's disease therapy. III. The PyridoTacrines.European journal of medicinal chemistry, , Mar-15, Volume: 166, 2019
Design, synthesis, and biological evaluation of rutacecarpine derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors.European journal of medicinal chemistry, , Nov-01, Volume: 181, 2019
Design, synthesis and biological evaluation of tacrine-1,2,3-triazole derivatives as potent cholinesterase inhibitors.MedChemComm, , Jan-01, Volume: 9, Issue:1, 2018
Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer's disease.European journal of medicinal chemistry, , Mar-25, Volume: 148, 2018
Developing hybrid molecule therapeutics for diverse enzyme inhibitory action: Active role of coumarin-based structural leads in drug discovery.Bioorganic & medicinal chemistry, , 07-30, Volume: 26, Issue:13, 2018
Tetrahydroacridine derivatives with dichloronicotinic acid moiety as attractive, multipotent agents for Alzheimer's disease treatment.European journal of medicinal chemistry, , Feb-10, Volume: 145, 2018
Druggability Assessment of Targets Used in Kinetic Target-Guided Synthesis.Journal of medicinal chemistry, , 11-08, Volume: 61, Issue:21, 2018
Development of tacrine-bifendate conjugates with improved cholinesterase inhibitory and pro-cognitive efficacy and reduced hepatotoxicity.European journal of medicinal chemistry, , Jan-20, Volume: 144, 2018
Selected aryl thiosemicarbazones as a new class of multi-targeted monoamine oxidase inhibitors.MedChemComm, , Nov-01, Volume: 9, Issue:11, 2018
Synthesis and activity towards Alzheimer's disease in vitro: Tacrine, phenolic acid and ligustrazine hybrids.European journal of medicinal chemistry, , Mar-25, Volume: 148, 2018
[no title available]Bioorganic & medicinal chemistry, , 06-15, Volume: 25, Issue:12, 2017
Novel tacrine-1,2,3-triazole hybrids: In vitro, in vivo biological evaluation and docking study of cholinesterase inhibitors.European journal of medicinal chemistry, , Jan-05, Volume: 125, 2017
New racemic annulated pyrazolo[1,2-b]phthalazines as tacrine-like AChE inhibitors with potential use in Alzheimer's disease.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
New tacrine-derived AChE/BuChE inhibitors: Synthesis and biological evaluation of 5-amino-2-phenyl-4H-pyrano[2,3-b]quinoline-3-carboxylates.European journal of medicinal chemistry, , Mar-10, Volume: 128, 2017
Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation.European journal of medicinal chemistry, , Jan-05, Volume: 125, 2017
Rational design, synthesis and biological screening of triazine-triazolopyrimidine hybrids as multitarget anti-Alzheimer agents.European journal of medicinal chemistry, , Aug-18, Volume: 136, 2017
A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy.European journal of medicinal chemistry, , Jan-27, Volume: 126, 2017
Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jan-05, Volume: 125, 2017
Novel bipharmacophoric inhibitors of the cholinesterases with affinity to the muscarinic receptors MMedChemComm, , Jun-01, Volume: 8, Issue:6, 2017
Novel tacrine derivatives exhibiting improved acetylcholinesterase inhibition: Design, synthesis and biological evaluation.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents.European journal of medicinal chemistry, , Sep-29, Volume: 138, 2017
Tetrahydroacridine derivatives with fluorobenzoic acid moiety as multifunctional agents for Alzheimer's disease treatment.Bioorganic chemistry, , Volume: 72, 2017
Evaluation of multifunctional synthetic tetralone derivatives for treatment of Alzheimer's disease.Chemical biology & drug design, , Volume: 88, Issue:6, 2016
Synthesis of new donepezil analogues and investigation of their effects on cholinesterase enzymes.European journal of medicinal chemistry, , Nov-29, Volume: 124, 2016
Synthesis and structure-activity relationship study of tacrine-based pyrano[2,3-c]pyrazoles targeting AChE/BuChE and 15-LOX.European journal of medicinal chemistry, , Nov-10, Volume: 123, 2016
Biological evaluation of synthetic α,β-unsaturated carbonyl based cyclohexanone derivatives as neuroprotective novel inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation.Bioorganic & medicinal chemistry, , 05-15, Volume: 24, Issue:10, 2016
The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators.Journal of medicinal chemistry, , 11-10, Volume: 59, Issue:21, 2016
Multitarget-directed oxoisoaporphine derivatives: Anti-acetylcholinesterase, anti-β-amyloid aggregation and enhanced autophagy activity against Alzheimer's disease.Bioorganic & medicinal chemistry, , 11-15, Volume: 24, Issue:22, 2016
Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Nov-10, Volume: 123, 2016
Avarol derivatives as competitive AChE inhibitors, non hepatotoxic and neuroprotective agents for Alzheimer's disease.European journal of medicinal chemistry, , Oct-21, Volume: 122, 2016
Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , Apr-01, Volume: 24, Issue:7, 2016
Development of cyanopyridine-triazine hybrids as lead multitarget anti-Alzheimer agents.Bioorganic & medicinal chemistry, , 06-15, Volume: 24, Issue:12, 2016
Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening.Journal of medicinal chemistry, , 08-25, Volume: 59, Issue:16, 2016
Cholinesterase inhibitory activity of chlorophenoxy derivatives-Histamine H3 receptor ligands.Bioorganic & medicinal chemistry letters, , 08-15, Volume: 26, Issue:16, 2016
Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as multi-targeted compounds against Alzheimer's disease.European journal of medicinal chemistry, , Jun-30, Volume: 116, 2016
Synthesis and screening of triazolopyrimidine scaffold as multi-functional agents for Alzheimer's disease therapies.European journal of medicinal chemistry, , Aug-25, Volume: 119, 2016
Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HTEuropean journal of medicinal chemistry, , Nov-29, Volume: 124, 2016
Potent anticholinesterasic and neuroprotective pyranotacrines as inhibitors of beta-amyloid aggregation, oxidative stress and tau-phosphorylation for Alzheimer's disease.European journal of medicinal chemistry, , Aug-08, Volume: 118, 2016
2-Benzoyl-6-benzylidenecyclohexanone analogs as potent dual inhibitors of acetylcholinesterase and butyrylcholinesterase.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
In silico to in vitro screening of hydroxypyridinones as acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 26, Issue:6, 2016
Design, synthesis and evaluation of 4-dimethylamine flavonoid derivatives as potential multifunctional anti-Alzheimer agents.European journal of medicinal chemistry, , Oct-21, Volume: 122, 2016
Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin.Bioorganic & medicinal chemistry, , 09-15, Volume: 24, Issue:18, 2016
Synthesis, pharmacological assessment, molecular modeling and in silico studies of fused tricyclic coumarin derivatives as a new family of multifunctional anti-Alzheimer agents.European journal of medicinal chemistry, , Jan-01, Volume: 107, 2016
Synthesis and anti-acetylcholinesterase activity of scopoletin derivatives.Bioorganic chemistry, , Volume: 65, 2016
Synthesis and anticholinergic activity of 4-hydroxycoumarin derivatives containing substituted benzyl-1,2,3-triazole moiety.Chemical biology & drug design, , Volume: 86, Issue:5, 2015
Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 25, Issue:4, 2015
Iminosugars as a new class of cholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 25, Issue:4, 2015
New tetracyclic tacrine analogs containing pyrano[2,3-c]pyrazole: efficient synthesis, biological assessment and docking simulation study.European journal of medicinal chemistry, , Jan-07, Volume: 89, 2015
Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and β-amyloid aggregation inhibitors with neuroprotective properties.European journal of medicinal chemistry, , Mar-06, Volume: 92, 2015
Multifunctional tacrine-trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties.European journal of medicinal chemistry, , Mar-26, Volume: 93, 2015
Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Isoindoline-1,3-dione derivatives targeting cholinesterases: design, synthesis and biological evaluation of potential anti-Alzheimer's agents.Bioorganic & medicinal chemistry, , Apr-01, Volume: 23, Issue:7, 2015
Ethynylphenyl carbonates and carbamates as dual-action acetylcholinesterase inhibitors and anti-inflammatory agents.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Design, synthesis and anticholinesterase activity of novel benzylidenechroman-4-ones bearing cyclic amine side chain.European journal of medicinal chemistry, , Jun-05, Volume: 97, 2015
Evaluation of Homobivalent Carbolines as Designed Multiple Ligands for the Treatment of Neurodegenerative Disorders.Journal of medicinal chemistry, , Aug-27, Volume: 58, Issue:16, 2015
Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.European journal of medicinal chemistry, , May-05, Volume: 95, 2015
Synthesis, biological evaluation and molecular modeling of new tetrahydroacridine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , Sep-01, Volume: 23, Issue:17, 2015
Discovery of new acetylcholinesterase inhibitors with small core structures through shape-based virtual screening.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 25, Issue:17, 2015
Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with 'inverted' binding mode.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease.European journal of medicinal chemistry, , Nov-24, Volume: 87, 2014
Chemical composition of the bark of Tetrapterys mucronata and identification of acetylcholinesterase inhibitory constituents.Journal of natural products, , Mar-28, Volume: 77, Issue:3, 2014
Quinolone-benzylpiperidine derivatives as novel acetylcholinesterase inhibitor and antioxidant hybrids for Alzheimer disease.Bioorganic & medicinal chemistry, , Apr-15, Volume: 22, Issue:8, 2014
Toxicological and pharmacological evaluation, antioxidant, ADMET and molecular modeling of selected racemic chromenotacrines {11-amino-12-aryl-8,9,10,12-tetrahydro-7H-chromeno[2,3-b]quinolin-3-ols} for the potential prevention and treatment of Alzheimer'sEuropean journal of medicinal chemistry, , Mar-03, Volume: 74, 2014
Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , Nov-01, Volume: 22, Issue:21, 2014
Novel aromatic-polyamine conjugates as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase.Bioorganic & medicinal chemistry, , Jun-15, Volume: 22, Issue:12, 2014
Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer's disease.Bioorganic & medicinal chemistry, , Feb-15, Volume: 22, Issue:4, 2014
2-(2-indolyl-)-4(3H)-quinazolines derivates as new inhibitors of AChE: design, synthesis, biological evaluation and molecular modelling.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:3, 2013
Design, synthesis and evaluation of novel 4-dimethylamine flavonoid derivatives as potential multi-functional anti-Alzheimer agents.Bioorganic & medicinal chemistry, , Dec-01, Volume: 21, Issue:23, 2013
Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.Bioorganic & medicinal chemistry, , Dec-01, Volume: 21, Issue:23, 2013
Novel tacrine-ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 23, Issue:24, 2013
Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen.Journal of medicinal chemistry, , Nov-27, Volume: 56, Issue:22, 2013
Multifunctional tacrine-flavonoid hybrids with cholinergic, β-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Volume: 69, 2013
Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease.European journal of medicinal chemistry, , Volume: 64, 2013
Design, synthesis, docking study and biological evaluation of some novel tetrahydrochromeno [3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one derivatives against acetyl- and butyrylcholinesterase.European journal of medicinal chemistry, , Volume: 68, 2013
Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi-targeted compounds against Alzheimer's disease.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer's disease.Bioorganic & medicinal chemistry letters, , May-01, Volume: 23, Issue:9, 2013
A novel series of tacrine-selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Volume: 62, 2013
Acetylcholinesterase immobilized capillary reactors-tandem mass spectrometry: an on-flow tool for ligand screening.Journal of medicinal chemistry, , Mar-14, Volume: 56, Issue:5, 2013
Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Investigation of the role of linker moieties in bifunctional tacrine hybrids.Bioorganic & medicinal chemistry, , Jun-15, Volume: 21, Issue:12, 2013
Synthesis and evaluation of 7,8-dehydrorutaecarpine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Volume: 63, 2013
NO-donating tacrine derivatives as potential butyrylcholinesterase inhibitors with vasorelaxation activity.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 23, Issue:11, 2013
Tacrine-silibinin codrug shows neuro- and hepatoprotective effects in vitro and pro-cognitive and hepatoprotective effects in vivo.Journal of medicinal chemistry, , Jun-14, Volume: 55, Issue:11, 2012
Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 22, Issue:20, 2012
O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-β aggregation.Bioorganic & medicinal chemistry, , Oct-01, Volume: 20, Issue:19, 2012
Multifunctional mercapto-tacrine derivatives for treatment of age-related neurodegenerative diseases.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids.Bioorganic & medicinal chemistry, , May-01, Volume: 20, Issue:9, 2012
Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 22, Issue:6, 2012
Acetylcholinesterase inhibitors from the leaves of Macaranga kurzii.Journal of natural products, , Nov-26, Volume: 75, Issue:11, 2012
Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.European journal of medicinal chemistry, , Volume: 52, 2012
Design, synthesis and evaluation of isaindigotone derivatives as dual inhibitors for acetylcholinesterase and amyloid beta aggregation.Bioorganic & medicinal chemistry, , Apr-15, Volume: 20, Issue:8, 2012
Novel multipotent phenylthiazole-tacrine hybrids for the inhibition of cholinesterase activity, β-amyloid aggregation and Ca²⁺ overload.Bioorganic & medicinal chemistry, , Nov-01, Volume: 20, Issue:21, 2012
Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 22, Issue:13, 2012
Synthesis and biological activity of derivatives of tetrahydroacridine as acetylcholinesterase inhibitors.Bioorganic chemistry, , Volume: 39, Issue:4, 2011
Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues.European journal of medicinal chemistry, , Volume: 46, Issue:12, 2011
Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation.European journal of medicinal chemistry, , Volume: 46, Issue:12, 2011
Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors.European journal of medicinal chemistry, , Volume: 46, Issue:10, 2011
New class of acetylcholinesterase inhibitors from the stem bark of Knema laurina and their structural insights.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 21, Issue:13, 2011
Synthesis, biological assessment and molecular modeling of 14-aryl-10,11,12,14-tetrahydro-9H-benzo[5,6]chromeno[2,3-b]quinolin-13-amines.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 21, Issue:8, 2011
Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
New potent human acetylcholinesterase inhibitors in the tetracyclic triterpene series with inhibitory potency on amyloid β aggregation.European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists.European journal of medicinal chemistry, , Volume: 46, Issue:1, 2011
Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles.Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregation.Bioorganic & medicinal chemistry, , Jan-15, Volume: 19, Issue:2, 2011
Syntheses and characterization of novel oxoisoaporphine derivatives as dual inhibitors for cholinesterases and amyloid beta aggregation.European journal of medicinal chemistry, , Volume: 46, Issue:5, 2011
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.Journal of medicinal chemistry, , Jul-22, Volume: 53, Issue:14, 2010
4-Aryl-4-oxo-N-phenyl-2-aminylbutyramides as acetyl- and butyrylcholinesterase inhibitors. Preparation, anticholinesterase activity, docking study, and 3D structure-activity relationship based on molecular interaction fields.Bioorganic & medicinal chemistry, , Volume: 18, Issue:3, 2010
Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents.Journal of medicinal chemistry, , May-13, Volume: 53, Issue:9, 2010
4-Phenylcoumarins from Mesua elegans with acetylcholinesterase inhibitory activity.Bioorganic & medicinal chemistry, , Nov-15, Volume: 18, Issue:22, 2010
Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Volume: 45, Issue:4, 2010
Novel alkyl- and arylcarbamate derivatives with N-benzylpiperidine and N-benzylpiperazine moieties as cholinesterases inhibitors.European journal of medicinal chemistry, , Volume: 45, Issue:12, 2010
Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Hybrid molecules from xanomeline and tacrine: enhanced tacrine actions on cholinesterases and muscarinic M1 receptors.Journal of medicinal chemistry, , Mar-11, Volume: 53, Issue:5, 2010
Berberine derivatives, with substituted amino groups linked at the 9-position, as inhibitors of acetylcholinesterase/butyrylcholinesterase.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 20, Issue:22, 2010
Nostotrebin 6, a bis(cyclopentenedione) with cholinesterase inhibitory activity isolated from Nostoc sp. str. Lukesová 27/97.Journal of enzyme inhibition and medicinal chemistry, , Volume: 25, Issue:3, 2010
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates.Bioorganic & medicinal chemistry letters, , May-01, Volume: 18, Issue:9, 2008
Design, synthesis and evaluation of isaindigotone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 18, Issue:13, 2008
NO-donating tacrine hybrid compounds improve scopolamine-induced cognition impairment and show less hepatotoxicity.Journal of medicinal chemistry, , Dec-25, Volume: 51, Issue:24, 2008
New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties.Bioorganic & medicinal chemistry, , Aug-15, Volume: 16, Issue:16, 2008
First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor.Journal of medicinal chemistry, , Nov-15, Volume: 50, Issue:23, 2007
New potent acetylcholinesterase inhibitors in the tetracyclic triterpene series.Journal of medicinal chemistry, , Nov-01, Volume: 50, Issue:22, 2007
Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics.Bioorganic & medicinal chemistry, , Oct-15, Volume: 15, Issue:20, 2007
Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease.Journal of medicinal chemistry, , Dec-28, Volume: 49, Issue:26, 2006
Taspine: bioactivity-guided isolation and molecular ligand-target insight of a potent acetylcholinesterase inhibitor from Magnolia x soulangiana.Journal of natural products, , Volume: 69, Issue:9, 2006
Synthesis of tricyclic 1,3-oxazin-4-ones and kinetic analysis of cholesterol esterase and acetylcholinesterase inhibition.Journal of medicinal chemistry, , Dec-29, Volume: 48, Issue:26, 2005
Synthesis and structure-activity relationships of open D-Ring galanthamine analogues.Bioorganic & medicinal chemistry letters, , Jul-21, Volume: 13, Issue:14, 2003
Design, synthesis, and structure-activity relationships of a series of 3-[2-(1-benzylpiperidin-4-yl)ethylamino]pyridazine derivatives as acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Aug-16, Volume: 44, Issue:17, 2001
Potent acetylcholinesterase inhibitors: design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-galanthaminium salts.Bioorganic & medicinal chemistry letters, , Apr-03, Volume: 10, Issue:7, 2000
BACE1 inhibitory activity and molecular docking analysis of meroterpenoids from Sargassum serratifolium.Bioorganic & medicinal chemistry, , 08-01, Volume: 25, Issue:15, 2017
Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids.Bioorganic & medicinal chemistry, , May-01, Volume: 20, Issue:9, 2012
Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation.European journal of medicinal chemistry, , Volume: 46, Issue:12, 2011
Discovery of novel 2,3-dihydro-1H-inden-1-ones as dual PDE4/AChE inhibitors with more potency against neuroinflammation for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Aug-05, Volume: 238, 2022
Development of novel 2-aminoalkyl-6-(2-hydroxyphenyl)pyridazin-3(2H)-one derivatives as balanced multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Feb-15, Volume: 230, 2022
Design, synthesis, biological evaluation and molecular modeling of N-isobutyl-N-((2-(p-tolyloxymethyl)thiazol-4yl)methyl)benzo[d][1,3] dioxole-5-carboxamides as selective butyrylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , 04-01, Volume: 61, 2022
Development of 5-hydroxyl-1-azabenzanthrone derivatives as dual binding site and selective acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Apr-15, Volume: 234, 2022
Synthesis and biological evaluation of 4-hydroxy-methylpiperidinyl-N-benzyl-acylarylhydrazone hybrids designed as novel multifunctional drug candidates for Alzheimer's disease.Bioorganic & medicinal chemistry, , 10-01, Volume: 71, 2022
Discovery of novel β-carboline derivatives as selective AChE inhibitors with GSK-3β inhibitory property for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Feb-05, Volume: 229, 2022
Design, synthesis, and biological evaluation of novel (4-(1,2,4-oxadiazol-5-yl)phenyl)-2-aminoacetamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jan-05, Volume: 227, 2022
Design, synthesis, and biological evaluation of carbamate derivatives of N-salicyloyl tryptamine as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Feb-05, Volume: 229, 2022
Design, synthesis and biological evaluation of new benzoxazolone/benzothiazolone derivatives as multi-target agents against Alzheimer's disease.European journal of medicinal chemistry, , Feb-15, Volume: 212, 2021
Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HTEuropean journal of medicinal chemistry, , Dec-05, Volume: 225, 2021
Novel arylcarbamate-N-acylhydrazones derivatives as promising BuChE inhibitors: Design, synthesis, molecular modeling and biological evaluation.Bioorganic & medicinal chemistry, , 02-15, Volume: 32, 2021
Discovery of 2-(cyclopropanecarboxamido)-N-(5-((1-(4-fluorobenzyl)piperidin-4-yl)methoxy)pyridin-3-yl)isonicotinamide as a potent dual AChE/GSK3β inhibitor for the treatment of Alzheimer's disease: Significantly increasing the level of acetylcholine in thEuropean journal of medicinal chemistry, , Nov-05, Volume: 223, 2021
Design, synthesis and evaluation of novel dimethylamino chalcone-O-alkylamines derivatives as potential multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Apr-15, Volume: 216, 2021
Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 04-01, Volume: 35, 2021
Novel cannabidiol-carbamate hybrids as selective BuChE inhibitors: Docking-based fragment reassembly for the development of potential therapeutic agents against Alzheimer's disease.European journal of medicinal chemistry, , Nov-05, Volume: 223, 2021
Discovery of multifunctional anti-Alzheimer's agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and γ-aminobutyric acid transporters.European journal of medicinal chemistry, , Jun-05, Volume: 218, 2021
Design, synthesis, and cholinesterase inhibition assay of liquiritigenin derivatives as anti-Alzheimer's activity.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 52, 2021
The structure-based optimization of δ-sultone-fused pyrazoles as selective BuChE inhibitors.European journal of medicinal chemistry, , Sep-01, Volume: 201, 2020
Discovery of methoxy-naphthyl linked N-(1-benzylpiperidine) benzamide as a blood-brain permeable dual inhibitor of acetylcholinesterase and butyrylcholinesterase.European journal of medicinal chemistry, , Dec-01, Volume: 207, 2020
The development of advanced structural framework as multi-target-directed ligands for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Apr-15, Volume: 192, 2020
1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Feb-01, Volume: 187, 2020
Chromone and donepezil hybrids as new multipotent cholinesterase and monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.RSC medicinal chemistry, , Feb-01, Volume: 11, Issue:2, 2020
Search for new multi-target compounds against Alzheimer's disease among histamine HEuropean journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
New coumarin-benzotriazole based hybrid molecules as inhibitors of acetylcholinesterase and amyloid aggregation.Bioorganic & medicinal chemistry letters, , 10-15, Volume: 30, Issue:20, 2020
Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease.Bioorganic & medicinal chemistry, , 04-15, Volume: 28, Issue:8, 2020
Synthesis and biological evaluation of 4-arylcoumarins as potential anti-Alzheimer's disease agents.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 30, Issue:4, 2020
Novel N-benzylpiperidine carboxamide derivatives as potential cholinesterase inhibitors for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Oct-01, Volume: 179, 2019
Microwave-Assisted Organic Synthesis, structure-activity relationship, kinetics and molecular docking studies of non-cytotoxic benzamide derivatives as selective butyrylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , 09-15, Volume: 27, Issue:18, 2019
Discovery of novel series of 2-substituted benzo[d]oxazol-5-amine derivatives as multi-target directed ligands for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Nov-15, Volume: 182, 2019
Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Sep-15, Volume: 178, 2019
The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 10-01, Volume: 29, Issue:19, 2019
Design, synthesis, and biological evaluation of novel 4-oxobenzo[d]1,2,3-triazin-benzylpyridinum derivatives as potent anti-Alzheimer agents.Bioorganic & medicinal chemistry, , 07-01, Volume: 27, Issue:13, 2019
Design and development of some phenyl benzoxazole derivatives as a potent acetylcholinesterase inhibitor with antioxidant property to enhance learning and memory.European journal of medicinal chemistry, , Feb-01, Volume: 163, 2019
Discovery of δ-sultone-fused pyrazoles for treating Alzheimer's disease: Design, synthesis, biological evaluation and SAR studies.European journal of medicinal chemistry, , Nov-01, Volume: 181, 2019
Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
A multifunctional therapeutic approach: Synthesis, biological evaluation, crystal structure and molecular docking of diversified 1H-pyrazolo[3,4-b]pyridine derivatives against Alzheimer's disease.European journal of medicinal chemistry, , Aug-01, Volume: 175, 2019
Naphthalene-triazolopyrimidine hybrid compounds as potential multifunctional anti-Alzheimer's agents.Bioorganic & medicinal chemistry, , 07-15, Volume: 27, Issue:14, 2019
Dipropargyl substituted diphenylpyrimidines as dual inhibitors of monoamine oxidase and acetylcholinesterase.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Design, synthesis, and biological evaluation of rutacecarpine derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors.European journal of medicinal chemistry, , Jan-01, Volume: 161, 2019
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Discovery of 4'-OH-flurbiprofen Mannich base derivatives as potential Alzheimer's disease treatment with multiple inhibitory activities.Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Benzoic acid-derived nitrones: A new class of potential acetylcholinesterase inhibitors and neuroprotective agents.European journal of medicinal chemistry, , Jul-15, Volume: 174, 2019
Tricyclic pyrazolo[1,5-d][1,4]benzoxazepin-5(6H)-one scaffold derivatives: Synthesis and biological evaluation as selective BuChE inhibitors.European journal of medicinal chemistry, , Mar-10, Volume: 147, 2018
Synthesis, structure-activity relationship and molecular docking studies of 3-O-flavonol glycosides as cholinesterase inhibitors.Bioorganic & medicinal chemistry, , 07-23, Volume: 26, Issue:12, 2018
Identification of dual Sigma1 receptor modulators/acetylcholinesterase inhibitors with antioxidant and neurotrophic properties, as neuroprotective agents.European journal of medicinal chemistry, , Oct-05, Volume: 158, 2018
Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 12-15, Volume: 26, Issue:23-24, 2018
Design, synthesis and evaluation of novel bivalent β-carboline derivatives as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 07-30, Volume: 26, Issue:13, 2018
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.Bioorganic & medicinal chemistry, , 05-01, Volume: 26, Issue:8, 2018
Development of Piperazinediones as dual inhibitor for treatment of Alzheimer's disease.European journal of medicinal chemistry, , Apr-25, Volume: 150, 2018
Design, synthesis and evaluation of novel multi-target-directed ligands for treatment of Alzheimer's disease based on coumarin and lipoic acid scaffolds.European journal of medicinal chemistry, , May-25, Volume: 152, 2018
Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties.European journal of medicinal chemistry, , Sep-05, Volume: 157, 2018
Design, synthesis, and biological evaluation of selective and potent Carbazole-based butyrylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , 09-15, Volume: 26, Issue:17, 2018
Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates.European journal of medicinal chemistry, , Mar-10, Volume: 147, 2018
In silico studies, synthesis and pharmacological evaluation to explore multi-targeted approach for imidazole analogues as potential cholinesterase inhibitors with neuroprotective role for Alzheimer's disease.Bioorganic & medicinal chemistry, , 05-01, Volume: 26, Issue:8, 2018
Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 27, Issue:22, 2017
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 06-15, Volume: 25, Issue:12, 2017
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jan-27, Volume: 126, 2017
Targeting Alzheimer's disease by investigating previously unexplored chemical space surrounding the cholinesterase inhibitor donepezil.European journal of medicinal chemistry, , Feb-15, Volume: 127, 2017
Synthesis, docking study and neuroprotective effects of some novel pyrano[3,2-c]chromene derivatives bearing morpholine/phenylpiperazine moiety.Bioorganic & medicinal chemistry, , 08-01, Volume: 25, Issue:15, 2017
[no title available]Bioorganic & medicinal chemistry, , 06-15, Volume: 25, Issue:12, 2017
Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.Bioorganic & medicinal chemistry, , 03-15, Volume: 25, Issue:6, 2017
Design, synthesis and evaluation of some N-methylenebenzenamine derivatives as selective acetylcholinesterase (AChE) inhibitor and antioxidant to enhance learning and memory.Bioorganic & medicinal chemistry, , 02-15, Volume: 25, Issue:4, 2017
Design, synthesis, in-silico and biological evaluation of novel donepezil derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jan-05, Volume: 125, 2017
Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties.Bioorganic & medicinal chemistry, , 01-15, Volume: 25, Issue:2, 2017
Design, synthesis and biological activity of novel donepezil derivatives bearing N-benzyl pyridinium moiety as potent and dual binding site acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Jun-16, Volume: 133, 2017
Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation.European journal of medicinal chemistry, , Jan-05, Volume: 125, 2017
Rational design, synthesis and biological screening of triazine-triazolopyrimidine hybrids as multitarget anti-Alzheimer agents.European journal of medicinal chemistry, , Aug-18, Volume: 136, 2017
A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Apr-21, Volume: 130, 2017
3,4-Dihydroquinazoline derivatives inhibit the activities of cholinesterase enzymes.Bioorganic & medicinal chemistry letters, , 03-01, Volume: 27, Issue:5, 2017
Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jul-28, Volume: 135, 2017
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 27, Issue:22, 2017
Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Apr-21, Volume: 130, 2017
Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jan-05, Volume: 125, 2017
Synthesis and pharmacological evaluation of multi-functional homoisoflavonoid derivatives as potent inhibitors of monoamine oxidase B and cholinesterase for the treatment of Alzheimer's disease.MedChemComm, , Jul-01, Volume: 8, Issue:7, 2017
Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
Synthesis and anticholinesterase activity of new substituted benzo[d]oxazole-based derivatives.Chemical biology & drug design, , Volume: 89, Issue:5, 2017
Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer's disease.Bioorganic chemistry, , Volume: 71, 2017
Evaluation of multifunctional synthetic tetralone derivatives for treatment of Alzheimer's disease.Chemical biology & drug design, , Volume: 88, Issue:6, 2016
Rational design and synthesis of dihydropyrimidine based dual binding site acetylcholinesterase inhibitors.Bioorganic chemistry, , Volume: 69, 2016
One-pot synthesis of tetrazole-1,2,5,6-tetrahydronicotinonitriles and cholinesterase inhibition: Probing the plausible reaction mechanism via computational studies.Bioorganic chemistry, , Volume: 65, 2016
Synthesis of new donepezil analogues and investigation of their effects on cholinesterase enzymes.European journal of medicinal chemistry, , Nov-29, Volume: 124, 2016
Design, synthesis, and AChE inhibitory activity of new benzothiazole-piperazines.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 26, Issue:22, 2016
Design, synthesis and evaluation of novel indandione derivatives as multifunctional agents with cholinesterase inhibition, anti-β-amyloid aggregation, antioxidant and neuroprotection properties against Alzheimer's disease.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Biological evaluation of synthetic α,β-unsaturated carbonyl based cyclohexanone derivatives as neuroprotective novel inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation.Bioorganic & medicinal chemistry, , 05-15, Volume: 24, Issue:10, 2016
Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents.Journal of medicinal chemistry, , 07-28, Volume: 59, Issue:14, 2016
Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Nov-10, Volume: 123, 2016
Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , Apr-01, Volume: 24, Issue:7, 2016
Design, synthesis and bioactivity of novel phthalimide derivatives as acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , May-01, Volume: 26, Issue:9, 2016
Development of cyanopyridine-triazine hybrids as lead multitarget anti-Alzheimer agents.Bioorganic & medicinal chemistry, , 06-15, Volume: 24, Issue:12, 2016
Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening.Journal of medicinal chemistry, , 08-25, Volume: 59, Issue:16, 2016
Cholinesterase inhibitory activity of chlorophenoxy derivatives-Histamine H3 receptor ligands.Bioorganic & medicinal chemistry letters, , 08-15, Volume: 26, Issue:16, 2016
Synthesis and biological evaluation of ranitidine analogs as multiple-target-directed cognitive enhancers for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 26, Issue:22, 2016
Synthesis and anticholinesterase activity of coumarin-3-carboxamides bearing tryptamine moiety.European journal of medicinal chemistry, , Oct-04, Volume: 121, 2016
Synthesis and screening of triazolopyrimidine scaffold as multi-functional agents for Alzheimer's disease therapies.European journal of medicinal chemistry, , Aug-25, Volume: 119, 2016
Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HTEuropean journal of medicinal chemistry, , Nov-29, Volume: 124, 2016
Pterostilbene-O-acetamidoalkylbenzylamines derivatives as novel dual inhibitors of cholinesterase with anti-β-amyloid aggregation and antioxidant properties for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 26, Issue:8, 2016
Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin.Bioorganic & medicinal chemistry, , 09-15, Volume: 24, Issue:18, 2016
Synthesis, pharmacological assessment, molecular modeling and in silico studies of fused tricyclic coumarin derivatives as a new family of multifunctional anti-Alzheimer agents.European journal of medicinal chemistry, , Jan-01, Volume: 107, 2016
Synthesis and anti-acetylcholinesterase activity of scopoletin derivatives.Bioorganic chemistry, , Volume: 65, 2016
Synthesis, biological evaluation and molecular docking study of novel piperidine and piperazine derivatives as multi-targeted agents to treat Alzheimer's disease.Bioorganic & medicinal chemistry, , Mar-01, Volume: 23, Issue:5, 2015
Design, synthesis and evaluation of chromone-2-carboxamido-alkylbenzylamines as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , Mar-01, Volume: 23, Issue:5, 2015
Synthesis of donepezil-based multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and β-amyloid aggregation inhibitors with neuroprotective properties.European journal of medicinal chemistry, , Mar-06, Volume: 92, 2015
Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Isoindoline-1,3-dione derivatives targeting cholinesterases: design, synthesis and biological evaluation of potential anti-Alzheimer's agents.Bioorganic & medicinal chemistry, , Apr-01, Volume: 23, Issue:7, 2015
Design, synthesis, biological evaluation and docking study of 4-isochromanone hybrids bearing N-benzyl pyridinium moiety as dual binding site acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 25, Issue:22, 2015
Blood-brain barrier permeable anticholinesterase aurones: synthesis, structure-activity relationship, and drug-like properties.European journal of medicinal chemistry, , Apr-13, Volume: 94, 2015
Multifunctional novel Diallyl disulfide (DADS) derivatives with β-amyloid-reducing, cholinergic, antioxidant and metal chelating properties for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , Oct-01, Volume: 23, Issue:19, 2015
Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Apr-13, Volume: 94, 2015
Design, synthesis and anticholinesterase activity of novel benzylidenechroman-4-ones bearing cyclic amine side chain.European journal of medicinal chemistry, , Jun-05, Volume: 97, 2015
Synthesis, cholinesterase inhibition and molecular modelling studies of coumarin linked thiourea derivatives.Bioorganic chemistry, , Volume: 63, 2015
Syntheses, cholinesterases inhibition, and molecular docking studies of pyrido[2,3-b]pyrazine derivatives.Chemical biology & drug design, , Volume: 86, Issue:5, 2015
Indolinone-based acetylcholinesterase inhibitors: synthesis, biological activity and molecular modeling.European journal of medicinal chemistry, , Sep-12, Volume: 84, 2014
Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease.European journal of medicinal chemistry, , Nov-24, Volume: 87, 2014
Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jun-10, Volume: 80, 2014
Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.European journal of medicinal chemistry, , Mar-21, Volume: 75, 2014
Active compounds from a diverse library of triazolothiadiazole and triazolothiadiazine scaffolds: synthesis, crystal structure determination, cytotoxicity, cholinesterase inhibitory activity, and binding mode analysis.Bioorganic & medicinal chemistry, , Nov-01, Volume: 22, Issue:21, 2014
Quinolone-benzylpiperidine derivatives as novel acetylcholinesterase inhibitor and antioxidant hybrids for Alzheimer disease.Bioorganic & medicinal chemistry, , Apr-15, Volume: 22, Issue:8, 2014
Design, synthesis and evaluation of genistein-O-alkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Apr-09, Volume: 76, 2014
Synthesis, crystal structure and biological evaluation of some novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines.European journal of medicinal chemistry, , May-06, Volume: 78, 2014
Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer's disease.Bioorganic & medicinal chemistry, , Feb-15, Volume: 22, Issue:4, 2014
Synthesis and anti-cholinesterase activity of new 7-hydroxycoumarin derivatives.European journal of medicinal chemistry, , Jul-23, Volume: 82, 2014
Synthesis, cytotoxicity and molecular modelling studies of new phenylcinnamide derivatives as potent inhibitors of cholinesterases.European journal of medicinal chemistry, , May-06, Volume: 78, 2014
Design, synthesis and evaluation of new thiazole-piperazines as acetylcholinesterase inhibitors.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:5, 2013
Synthesis and anticholinesterase activities of novel 1,3,4-thiadiazole based compounds.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:4, 2013
Novel coumarin-3-carboxamides bearing N-benzylpiperidine moiety as potent acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Volume: 70, 2013
Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen.Journal of medicinal chemistry, , Nov-27, Volume: 56, Issue:22, 2013
Design, synthesis, biological evaluation and docking study of 5-oxo-4,5-dihydropyrano[3,2-c]chromene derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors.European journal of medicinal chemistry, , Volume: 68, 2013
Design, synthesis and evaluation of some new 4-aminopyridine derivatives in learning and memory.Bioorganic & medicinal chemistry letters, , May-15, Volume: 23, Issue:10, 2013
Synthesis, evaluation and molecular dynamics study of some new 4-aminopyridine semicarbazones as an antiamnesic and cognition enhancing agents.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.European journal of medicinal chemistry, , Volume: 52, 2012
Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 22, Issue:13, 2012
Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's diJournal of medicinal chemistry, , Dec-22, Volume: 54, Issue:24, 2011
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.Journal of medicinal chemistry, , Jul-22, Volume: 53, Issue:14, 2010
Design, synthesis and evaluation of novel 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenyl-3,4-substituted phenyl methanone analogues.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 19, Issue:17, 2009
Design, synthesis, and acetylcholinesterase inhibitory activity of novel coumarin analogues.Bioorganic & medicinal chemistry, , Sep-01, Volume: 16, Issue:17, 2008
Design, synthesis, and structure-activity relationships of a series of 3-[2-(1-benzylpiperidin-4-yl)ethylamino]pyridazine derivatives as acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Aug-16, Volume: 44, Issue:17, 2001
Synthesis and activity studies of N-[omega-N'-(adamant-1'-yl)aminoalkyl]- 2-(4'-dimethylaminophenyl)acetamides: in the search of selective inhibitors for the different molecular forms of acetylcholinesterase.Bioorganic & medicinal chemistry letters, , Mar-17, Volume: 8, Issue:6, 1998
Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer's disease.Bioorganic & medicinal chemistry, , Feb-15, Volume: 22, Issue:4, 2014
Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen.Journal of medicinal chemistry, , Nov-27, Volume: 56, Issue:22, 2013
Novel BuChE-IDO1 inhibitors from sertaconazole: Virtual screening, chemical optimization and molecular modeling studies.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 34, 2021
Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease.Bioorganic & medicinal chemistry, , 05-01, Volume: 26, Issue:8, 2018
Synthesis and in vitro evaluation of vanillin derivatives as multi-target therapeutics for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 11-01, Volume: 30, Issue:21, 2020
Triazole derivatives as inhibitors of Alzheimer's disease: Current developments and structure-activity relationships.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
One-pot synthesis of tetrazole-1,2,5,6-tetrahydronicotinonitriles and cholinesterase inhibition: Probing the plausible reaction mechanism via computational studies.Bioorganic chemistry, , Volume: 65, 2016
Synthesis, cholinesterase inhibition and molecular modelling studies of coumarin linked thiourea derivatives.Bioorganic chemistry, , Volume: 63, 2015
Syntheses, cholinesterases inhibition, and molecular docking studies of pyrido[2,3-b]pyrazine derivatives.Chemical biology & drug design, , Volume: 86, Issue:5, 2015
Active compounds from a diverse library of triazolothiadiazole and triazolothiadiazine scaffolds: synthesis, crystal structure determination, cytotoxicity, cholinesterase inhibitory activity, and binding mode analysis.Bioorganic & medicinal chemistry, , Nov-01, Volume: 22, Issue:21, 2014
Synthesis, crystal structure and biological evaluation of some novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines.European journal of medicinal chemistry, , May-06, Volume: 78, 2014
Synthesis, cytotoxicity and molecular modelling studies of new phenylcinnamide derivatives as potent inhibitors of cholinesterases.European journal of medicinal chemistry, , May-06, Volume: 78, 2014
Synthesis and anticholinesterase activities of novel 1,3,4-thiadiazole based compounds.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:4, 2013
Cholinesterase Inhibitory Arisugacins L-Q from a Journal of natural products, , 09-27, Volume: 82, Issue:9, 2019
Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors.Journal of medicinal chemistry, , Oct-23, Volume: 51, Issue:20, 2008
Benzofuran-derived benzylpyridinium bromides as potent acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Mar-26, Volume: 93, 2015
Synthesis and evaluation of 4-substituted coumarins as novel acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Volume: 64, 2013
A one-pot domino synthesis and discovery of highly functionalized dihydrobenzo[b]thiophenes as AChE inhibitors.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 23, Issue:7, 2013
An atom economic synthesis and AChE inhibitory activity of novel dispiro 7-aryltetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole and 4-aryloctahydroindolizine N-methylpiperidin-4-one hybrid heterocycles.European journal of medicinal chemistry, , Volume: 65, 2013
Novel coumarin derivatives bearing N-benzyl pyridinium moiety: potent and dual binding site acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , Dec-15, Volume: 20, Issue:24, 2012
AChE inhibitor: a regio- and stereo-selective 1,3-dipolar cycloaddition for the synthesis of novel substituted 5,6-dimethoxy spiro[5.3']-oxindole-spiro-[6.3″]-2,3-dihydro-1H-inden-1″-one-7-(substituted aryl)-tetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 22, Issue:1, 2012
Synthesis and discovery of novel hexacyclic cage compounds as inhibitors of acetylcholinesterase.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 21, Issue:13, 2011
Design, synthesis and anticholinesterase activity of a novel series of 1-benzyl-4-((6-alkoxy-3-oxobenzofuran-2(3H)-ylidene) methyl) pyridinium derivatives.Bioorganic & medicinal chemistry, , Sep-01, Volume: 18, Issue:17, 2010
Spatial Distribution and Stability of Cholinesterase Inhibitory Protoberberine Alkaloids from Journal of natural products, , 01-28, Volume: 85, Issue:1, 2022
Synthesis and efficacy of 1-[bis(4-fluorophenyl)-methyl]piperazine derivatives for acetylcholinesterase inhibition, as a stimulant of central cholinergic neurotransmission in Alzheimer's disease.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 16, Issue:15, 2006
Arylsulfonyl histamine derivatives as powerful and selective α-glucosidase inhibitors.RSC medicinal chemistry, , Apr-01, Volume: 11, Issue:4, 2020
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Synthesis of novel 5-(aroylhydrazinocarbonyl)escitalopram as cholinesterase inhibitors.European journal of medicinal chemistry, , Sep-29, Volume: 138, 2017
Cholinesterase inhibitory activity of isoquinoline alkaloids from three Cryptocarya species (Lauraceae).Bioorganic & medicinal chemistry, , 09-15, Volume: 24, Issue:18, 2016
Pyridine sulfonamide as a small key organic molecule for the potential treatment of type-II diabetes mellitus and Alzheimer's disease: In vitro studies against yeast α-glucosidase, acetylcholinesterase and butyrylcholinesterase.Bioorganic chemistry, , Volume: 63, 2015
Identification of a neuroprotective and selective butyrylcholinesterase inhibitor derived from the natural alkaloid evodiamine.European journal of medicinal chemistry, , Jun-23, Volume: 81, 2014
Cyclic acyl guanidines bearing carbamate moieties allow potent and dirigible cholinesterase inhibition of either acetyl- or butyrylcholinesterase.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Neuroprotective Tri- and Tetracyclic BChE Inhibitors Releasing Reversible Inhibitors upon Carbamate Transfer.ACS medicinal chemistry letters, , Nov-08, Volume: 3, Issue:11, 2012
Isosorbide-2-benzyl carbamate-5-salicylate, a peripheral anionic site binding subnanomolar selective butyrylcholinesterase inhibitor.Journal of medicinal chemistry, , Feb-11, Volume: 53, Issue:3, 2010
Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors.Journal of medicinal chemistry, , Oct-23, Volume: 51, Issue:20, 2008
New triterpenoid alkaloid cholinesterase inhibitors from Buxus hyrcana.Journal of natural products, , Volume: 66, Issue:6, 2003
Steroidal alkaloids from the leaves of Sarcococca coriacea of Nepalese origin.Journal of natural products, , Volume: 64, Issue:6, 2001
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[no title available]Bioorganic & medicinal chemistry, , 06-15, Volume: 25, Issue:12, 2017
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Synthesis and biological evaluation of 1,3,4-thiadiazole analogues as novel AChE and BuChE inhibitors.European journal of medicinal chemistry, , Volume: 62, 2013
Active site directed docking studies: synthesis and pharmacological evaluation of cis-2,6-dimethyl piperidine sulfonamides as inhibitors of acetylcholinesterase.European journal of medicinal chemistry, , Volume: 44, Issue:10, 2009
Synthesis and screening for acetylcholinesterase inhibitor activity of some novel 2-butyl-1,3-diaza-spiro[4,4]non-1-en-4-ones: derivatives of irbesartan key intermediate.Bioorganic & medicinal chemistry, , Dec-01, Volume: 15, Issue:23, 2007
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Evaluation of chromane derivatives: Promising privileged scaffolds for lead discovery within Alzheimer's disease.Bioorganic & medicinal chemistry, , 08-15, Volume: 68, 2022
New naphtho/thienobenzo-triazoles with interconnected anti-inflammatory and cholinesterase inhibitory activity.European journal of medicinal chemistry, , Nov-05, Volume: 241, 2022
Ugi Reaction Synthesis of Oxindole-Lactam Hybrids as Selective Butyrylcholinesterase Inhibitors.ACS medicinal chemistry letters, , Nov-11, Volume: 12, Issue:11, 2021
Novel N-benzylpiperidine carboxamide derivatives as potential cholinesterase inhibitors for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Oct-01, Volume: 179, 2019
Dispiropyrrolidinyl-piperidone embedded indeno[1,2-b]quinoxaline heterocyclic hybrids: Synthesis, cholinesterase inhibitory activity and their molecular docking simulation.Bioorganic & medicinal chemistry, , 06-15, Volume: 27, Issue:12, 2019
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Design, synthesis, evaluation and molecular modeling study of 4-N-phenylaminoquinolines for Alzheimer disease treatment.Bioorganic & medicinal chemistry letters, , 06-01, Volume: 29, Issue:11, 2019
Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors.European journal of medicinal chemistry, , Nov-01, Volume: 181, 2019
Developing hybrid molecule therapeutics for diverse enzyme inhibitory action: Active role of coumarin-based structural leads in drug discovery.Bioorganic & medicinal chemistry, , 07-30, Volume: 26, Issue:13, 2018
A cascade synthesis, in vitro cholinesterases inhibitory activity and docking studies of novel Tacrine-pyranopyrazole derivatives.Bioorganic & medicinal chemistry letters, , 08-01, Volume: 28, Issue:14, 2018
2-Arylbenzofurans from Artocarpus lakoocha and methyl ether analogs with potent cholinesterase inhibitory activity.European journal of medicinal chemistry, , Jan-01, Volume: 143, 2018
Design, synthesis, and biological evaluation of selective and potent Carbazole-based butyrylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , 09-15, Volume: 26, Issue:17, 2018
In silico studies, synthesis and pharmacological evaluation to explore multi-targeted approach for imidazole analogues as potential cholinesterase inhibitors with neuroprotective role for Alzheimer's disease.Bioorganic & medicinal chemistry, , 05-01, Volume: 26, Issue:8, 2018
Synthesis of readily available fluorophenylalanine derivatives and investigation of their biological activity.Bioorganic chemistry, , Volume: 71, 2017
Targeting Alzheimer's disease by investigating previously unexplored chemical space surrounding the cholinesterase inhibitor donepezil.European journal of medicinal chemistry, , Feb-15, Volume: 127, 2017
[no title available]Bioorganic & medicinal chemistry, , 06-15, Volume: 25, Issue:12, 2017
Isosteroidal alkaloids as potent dual-binding site inhibitors of both acetylcholinesterase and butyrylcholinesterase from the bulbs of Fritillaria walujewii.European journal of medicinal chemistry, , Sep-08, Volume: 137, 2017
Amaryllidaceae alkaloids with new framework types from Zephyranthes candida as potent acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Feb-15, Volume: 127, 2017
Discorhabdin alkaloids from Antarctic Latrunculia spp. sponges as a new class of cholinesterase inhibitors.European journal of medicinal chemistry, , Aug-18, Volume: 136, 2017
Antioxidant and anticholinesterase potential of diterpenoid alkaloids from Aconitum heterophyllum.Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
Synthesis, anticholinesterase activity and molecular modeling study of novel carbamate-substituted thymol/carvacrol derivatives.Bioorganic & medicinal chemistry, , 02-15, Volume: 25, Issue:4, 2017
New azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity.European journal of medicinal chemistry, , Jan-05, Volume: 125, 2017
Synthesis, biological evaluation and docking studies of 2,3-dihydroquinazolin-4(1H)-one derivatives as inhibitors of cholinesterases.Bioorganic chemistry, , Volume: 70, 2017
Novel N-allyl/propargyl tetrahydroquinolines: Synthesis via Three-component Cationic Imino Diels-Alder Reaction, Binding Prediction, and Evaluation as Cholinesterase Inhibitors.Chemical biology & drug design, , Volume: 88, Issue:4, 2016
Rational design and synthesis of dihydropyrimidine based dual binding site acetylcholinesterase inhibitors.Bioorganic chemistry, , Volume: 69, 2016
Avarol derivatives as competitive AChE inhibitors, non hepatotoxic and neuroprotective agents for Alzheimer's disease.European journal of medicinal chemistry, , Oct-21, Volume: 122, 2016
Alkaloids from Hippeastrum argentinum and Their Cholinesterase-Inhibitory Activities: An in Vitro and in Silico Study.Journal of natural products, , 05-27, Volume: 79, Issue:5, 2016
New piperidine-hydrazone derivatives: Synthesis, biological evaluations and molecular docking studies as AChE and BChE inhibitors.European journal of medicinal chemistry, , Nov-29, Volume: 124, 2016
Synthesis and screening of triazolopyrimidine scaffold as multi-functional agents for Alzheimer's disease therapies.European journal of medicinal chemistry, , Aug-25, Volume: 119, 2016
Synthesis and evaluation of dihydropyrimidinone-derived selenoesters as multi-targeted directed compounds against Alzheimer's disease.Bioorganic & medicinal chemistry, , 11-15, Volume: 24, Issue:22, 2016
Ferulic acid-carbazole hybrid compounds: Combination of cholinesterase inhibition, antioxidant and neuroprotection as multifunctional anti-Alzheimer agents.Bioorganic & medicinal chemistry, , Feb-15, Volume: 24, Issue:4, 2016
Synthesis and evaluation of novel 1,2,3-triazole-based acetylcholinesterase inhibitors with neuroprotective activity.Bioorganic & medicinal chemistry letters, , 08-15, Volume: 26, Issue:16, 2016
Synthesis, pharmacological assessment, molecular modeling and in silico studies of fused tricyclic coumarin derivatives as a new family of multifunctional anti-Alzheimer agents.European journal of medicinal chemistry, , Jan-01, Volume: 107, 2016
New cholinesterase inhibitors for Alzheimer's disease: Structure Activity Studies (SARs) and molecular docking of isoquinolone and azepanone derivatives.Bioorganic chemistry, , Volume: 67, 2016
Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease.Chemical biology & drug design, , Volume: 88, Issue:1, 2016
In Vitro Inhibitory Effects of 8-O-Demethylmaritidine and Undulatine on Acetylcholinesterase and Their Predicted Penetration across the Blood-Brain Barrier.Journal of natural products, , Jun-26, Volume: 78, Issue:6, 2015
Potential of aryl-urea-benzofuranylthiazoles hybrids as multitasking agents in Alzheimer's disease.European journal of medicinal chemistry, , Sep-18, Volume: 102, 2015
Synthesis, antioxidant and anticholinesterase activities of novel coumarylthiazole derivatives.Bioorganic chemistry, , Volume: 59, 2015
Salicylanilide diethyl phosphates as cholinesterases inhibitors.Bioorganic chemistry, , Volume: 58, 2015
Chemical composition of the bark of Tetrapterys mucronata and identification of acetylcholinesterase inhibitory constituents.Journal of natural products, , Mar-28, Volume: 77, Issue:3, 2014
Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer's disease.Bioorganic & medicinal chemistry letters, , May-15, Volume: 24, Issue:10, 2014
Synthesis and discovery of highly functionalized mono- and bis-spiro-pyrrolidines as potent cholinesterase enzyme inhibitors.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 24, Issue:7, 2014
Cholinesterase inhibitory activity versus aromatic core multiplicity: a facile green synthesis and molecular docking study of novel piperidone embedded thiazolopyrimidines.Bioorganic & medicinal chemistry, , Jan-15, Volume: 22, Issue:2, 2014
Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , Nov-01, Volume: 22, Issue:21, 2014
Design, synthesis and biological evaluation of D-ring opened galantamine analogs as multifunctional anti-Alzheimer agents.European journal of medicinal chemistry, , Apr-09, Volume: 76, 2014
Multifunctional tacrine-flavonoid hybrids with cholinergic, β-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Volume: 69, 2013
An expedient, ionic liquid mediated multi-component synthesis of novel piperidone grafted cholinesterase enzymes inhibitors and their molecular modeling study.European journal of medicinal chemistry, , Volume: 67, 2013
Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease.European journal of medicinal chemistry, , Volume: 64, 2013
Synthesis and in vitro evaluation of new derivatives of 2-substituted-6-fluorobenzo[d]thiazoles as cholinesterase inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 21, Issue:7, 2013
Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer's disease.Bioorganic & medicinal chemistry letters, , May-01, Volume: 23, Issue:9, 2013
Microwave assisted synthesis, cholinesterase enzymes inhibitory activities and molecular docking studies of new pyridopyrimidine derivatives.Bioorganic & medicinal chemistry, , Jun-01, Volume: 21, Issue:11, 2013
Novel racemic tetrahydrocurcuminoid dihydropyrimidinone analogues as potent acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , May-15, Volume: 23, Issue:10, 2013
Acetylcholinesterase immobilized capillary reactors-tandem mass spectrometry: an on-flow tool for ligand screening.Journal of medicinal chemistry, , Mar-14, Volume: 56, Issue:5, 2013
Prospective acetylcholinesterase inhibitory activity of indole and its analogs.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 22, Issue:8, 2012
Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 22, Issue:13, 2012
Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Benzenediol-berberine hybrids: multifunctional agents for Alzheimer's disease.Bioorganic & medicinal chemistry, , Dec-01, Volume: 19, Issue:23, 2011
Mycobacterium tuberculosis and cholinesterase inhibitors from Voacanga globosa.European journal of medicinal chemistry, , Volume: 46, Issue:7, 2011
Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and β-amyloid aggregation inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 19, Issue:7, 2011
Nantenine as an acetylcholinesterase inhibitor: SAR, enzyme kinetics and molecular modeling investigations.Journal of enzyme inhibition and medicinal chemistry, , Volume: 26, Issue:1, 2011
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.Journal of medicinal chemistry, , Jul-22, Volume: 53, Issue:14, 2010
Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents.Journal of medicinal chemistry, , May-13, Volume: 53, Issue:9, 2010
Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyriBioorganic & medicinal chemistry, , Aug-15, Volume: 18, Issue:16, 2010
Indole alkaloids from Ervatamia hainanensis with potent acetylcholinesterase inhibition activities.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 20, Issue:21, 2010
Morphinans and isoquinolines: acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors.Bioorganic & medicinal chemistry, , Jul-15, Volume: 18, Issue:14, 2010
Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , Volume: 18, Issue:3, 2010
Characterization of Acetylcholinesterase Inhibitory Constituents from Annona glabra Assisted by HPLC Microfractionation.Journal of natural products, , Oct-22, Volume: 73, Issue:10, 2010
Bivalent 5,8,9,13b-tetrahydro-6H-isoquino[1,2-a]isoquinolines and -isoquinolinium salts: novel heterocyclic templates for butyrylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , May-01, Volume: 20, Issue:9, 2010
Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase.Bioorganic & medicinal chemistry, , Jun-15, Volume: 18, Issue:12, 2010
Nostotrebin 6, a bis(cyclopentenedione) with cholinesterase inhibitory activity isolated from Nostoc sp. str. Lukesová 27/97.Journal of enzyme inhibition and medicinal chemistry, , Volume: 25, Issue:3, 2010
Synthesis, biological evaluation and molecular modeling of oxoisoaporphine and oxoaporphine derivatives as new dual inhibitors of acetylcholinesterase/butyrylcholinesterase.European journal of medicinal chemistry, , Volume: 44, Issue:6, 2009
Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties.Bioorganic & medicinal chemistry, , Apr-15, Volume: 16, Issue:8, 2008
N-Alkylated galanthamine derivatives: Potent acetylcholinesterase inhibitors from Leucojum aestivum.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 18, Issue:7, 2008
Preparation of secolycorines against acetylcholinesterase.Bioorganic & medicinal chemistry, , Jan-15, Volume: 15, Issue:2, 2007
New potent acetylcholinesterase inhibitors in the tetracyclic triterpene series.Journal of medicinal chemistry, , Nov-01, Volume: 50, Issue:22, 2007
Derivatives of oxoisoaporphine alkaloids: a novel class of selective acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum.Bioorganic & medicinal chemistry letters, , Volume: 16, Issue:3, 2006
Taspine: bioactivity-guided isolation and molecular ligand-target insight of a potent acetylcholinesterase inhibitor from Magnolia x soulangiana.Journal of natural products, , Volume: 69, Issue:9, 2006
Homobivalent quinazolinimines as novel nanomolar inhibitors of cholinesterases with dirigible selectivity toward butyrylcholinesterase.Journal of medicinal chemistry, , Sep-07, Volume: 49, Issue:18, 2006
Synthesis of tricyclic 1,3-oxazin-4-ones and kinetic analysis of cholesterol esterase and acetylcholinesterase inhibition.Journal of medicinal chemistry, , Dec-29, Volume: 48, Issue:26, 2005
The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design.Journal of the American Chemical Society, , Dec-01, Volume: 126, Issue:47, 2004
Synthesis and structure-activity relationships of open D-Ring galanthamine analogues.Bioorganic & medicinal chemistry letters, , Jul-21, Volume: 13, Issue:14, 2003
Potent acetylcholinesterase inhibitors: design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-galanthaminium salts.Bioorganic & medicinal chemistry letters, , Apr-03, Volume: 10, Issue:7, 2000
Synthesis and biological evaluation of berberine-thiophenyl hybrids as multi-functional agents: Inhibition of acetylcholinesterase, butyrylcholinesterase, and Aβ aggregation and antioxidant activity.Bioorganic & medicinal chemistry, , Sep-15, Volume: 21, Issue:18, 2013
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.Bioorganic & medicinal chemistry, , Nov-15, Volume: 20, Issue:22, 2012
Benzenediol-berberine hybrids: multifunctional agents for Alzheimer's disease.Bioorganic & medicinal chemistry, , Dec-01, Volume: 19, Issue:23, 2011
Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and β-amyloid aggregation inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 19, Issue:7, 2011
Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , Volume: 18, Issue:3, 2010
Berberine derivatives, with substituted amino groups linked at the 9-position, as inhibitors of acetylcholinesterase/butyrylcholinesterase.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 20, Issue:22, 2010
Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase.Bioorganic & medicinal chemistry, , Jun-15, Volume: 18, Issue:12, 2010
Design, synthesis, and biological evaluation of rutacecarpine derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Volume: 45, Issue:4, 2010
Development of novel 2-aminoalkyl-6-(2-hydroxyphenyl)pyridazin-3(2H)-one derivatives as balanced multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Feb-15, Volume: 230, 2022
Selective butyrylcholinesterase inhibition by isatin dimers and 3-indolyl-3-hydroxy-2-oxindole dimers.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 77, 2022
Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 04-01, Volume: 35, 2021
Novel cannabidiol-carbamate hybrids as selective BuChE inhibitors: Docking-based fragment reassembly for the development of potential therapeutic agents against Alzheimer's disease.European journal of medicinal chemistry, , Nov-05, Volume: 223, 2021
The structure-based optimization of δ-sultone-fused pyrazoles as selective BuChE inhibitors.European journal of medicinal chemistry, , Sep-01, Volume: 201, 2020
Design, synthesis and biological evaluation of novel carbamates as potential inhibitors of acetylcholinesterase and butyrylcholinesterase.Bioorganic & medicinal chemistry, , 03-01, Volume: 28, Issue:5, 2020
Design, synthesis and evaluation of new 4-arylthiazole-2-amine derivatives as acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , 03-15, Volume: 30, Issue:6, 2020
Synthesis, in vitro and in vivo biological evaluation of novel graveolinine derivatives as potential anti-Alzheimer agents.Bioorganic & medicinal chemistry, , 01-01, Volume: 28, Issue:1, 2020
Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , May-15, Volume: 194, 2020
Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Sep-15, Volume: 178, 2019
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Discovery of δ-sultone-fused pyrazoles for treating Alzheimer's disease: Design, synthesis, biological evaluation and SAR studies.European journal of medicinal chemistry, , Nov-01, Volume: 181, 2019
Developing hybrid molecule therapeutics for diverse enzyme inhibitory action: Active role of coumarin-based structural leads in drug discovery.Bioorganic & medicinal chemistry, , 07-30, Volume: 26, Issue:13, 2018
Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 12-15, Volume: 26, Issue:23-24, 2018
Synthesis of readily available fluorophenylalanine derivatives and investigation of their biological activity.Bioorganic chemistry, , Volume: 71, 2017
Novel tacrine-1,2,3-triazole hybrids: In vitro, in vivo biological evaluation and docking study of cholinesterase inhibitors.European journal of medicinal chemistry, , Jan-05, Volume: 125, 2017
Synthesis, anticholinesterase activity and molecular modeling study of novel carbamate-substituted thymol/carvacrol derivatives.Bioorganic & medicinal chemistry, , 02-15, Volume: 25, Issue:4, 2017
Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 02-01, Volume: 25, Issue:3, 2017
Synthesis of novel chromenones linked to 1,2,3-triazole ring system: Investigation of biological activities against Alzheimer's disease.Bioorganic chemistry, , Volume: 70, 2017
Design and synthesis of novel anti-Alzheimer's agents: Acridine-chromenone and quinoline-chromenone hybrids.Bioorganic chemistry, , Volume: 67, 2016
Design, synthesis and evaluation of novel 7-aminoalkyl-substituted flavonoid derivatives with improved cholinesterase inhibitory activities.Bioorganic & medicinal chemistry, , Feb-15, Volume: 24, Issue:4, 2016
Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening.Journal of medicinal chemistry, , 08-25, Volume: 59, Issue:16, 2016
Synthesis and screening of triazolopyrimidine scaffold as multi-functional agents for Alzheimer's disease therapies.European journal of medicinal chemistry, , Aug-25, Volume: 119, 2016
Synthesis, structural characterization, docking, lipophilicity and cytotoxicity of 1-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]-3-alkyl carbamates, novel acetylcholinesterase and butyrylcholinesterase pseudo-irreversible inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 24, Issue:7, 2016
Pterostilbene-O-acetamidoalkylbenzylamines derivatives as novel dual inhibitors of cholinesterase with anti-β-amyloid aggregation and antioxidant properties for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 26, Issue:8, 2016
In silico to in vitro screening of hydroxypyridinones as acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 26, Issue:6, 2016
Design and discovery of Novel Thiazole acetamide derivatives as anticholinesterase agent for possible role in the management of Alzheimer's.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 26, Issue:3, 2016
Synthesis, pharmacological assessment, molecular modeling and in silico studies of fused tricyclic coumarin derivatives as a new family of multifunctional anti-Alzheimer agents.European journal of medicinal chemistry, , Jan-01, Volume: 107, 2016
Design, Synthesis, Biological Evaluation, and Docking Study of Acetylcholinesterase Inhibitors: New Acridone-1,2,4-oxadiazole-1,2,3-triazole Hybrids.Chemical biology & drug design, , Volume: 86, Issue:6, 2015
Potent acetylcholinesterase inhibitors: design, synthesis, biological evaluation, and docking study of acridone linked to 1,2,3-triazole derivatives.European journal of medicinal chemistry, , Mar-06, Volume: 92, 2015
Synthesis, biological evaluation and molecular modeling of new tetrahydroacridine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , Sep-01, Volume: 23, Issue:17, 2015
Salicylanilide diethyl phosphates as cholinesterases inhibitors.Bioorganic chemistry, , Volume: 58, 2015
Design, synthesis and evaluation of novel 4-dimethylamine flavonoid derivatives as potential multi-functional anti-Alzheimer agents.Bioorganic & medicinal chemistry, , Dec-01, Volume: 21, Issue:23, 2013
Synthesis and in vitro evaluation of new derivatives of 2-substituted-6-fluorobenzo[d]thiazoles as cholinesterase inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 21, Issue:7, 2013
Synthesis and biological evaluation of novel N,N'-bis-methylenedioxybenzyl-alkylenediamines as bivalent anti-Alzheimer disease ligands.Journal of enzyme inhibition and medicinal chemistry, , Volume: 26, Issue:5, 2011
Novel alkyl- and arylcarbamate derivatives with N-benzylpiperidine and N-benzylpiperazine moieties as cholinesterases inhibitors.European journal of medicinal chemistry, , Volume: 45, Issue:12, 2010
Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyriBioorganic & medicinal chemistry, , Aug-15, Volume: 18, Issue:16, 2010
New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties.Bioorganic & medicinal chemistry, , Aug-15, Volume: 16, Issue:16, 2008
Zamamiphidins B and C, Manzamine-Related Alkaloids from an Journal of natural products, , 09-23, Volume: 85, Issue:9, 2022
Caffeic acid phenethyl ester (CAPE)-derivatives act as selective inhibitors of acetylcholinesterase.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Unexpected AChE inhibitory activity of (2E)α,β-unsaturated fatty acids.Bioorganic & medicinal chemistry letters, , 11-01, Volume: 28, Issue:20, 2018
Repurposing N,N'-bis-(arylamidino)-1,4-piperazinedicarboxamidines: An unexpected class of potent inhibitors of cholinesterases.European journal of medicinal chemistry, , Jan-05, Volume: 125, 2017
Piperlongumine B and analogs are promising and selective inhibitors for acetylcholinesterase.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
Amino derivatives of platanic acid act as selective and potent inhibitors of butyrylcholinesterase.European journal of medicinal chemistry, , Jan-27, Volume: 126, 2017
Converting maslinic acid into an effective inhibitor of acylcholinesterases.European journal of medicinal chemistry, , Oct-20, Volume: 103, 2015
Allobetulin derived seco-oleananedicarboxylates act as inhibitors of acetylcholinesterase.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 25, Issue:13, 2015
Amino derivatives of glycyrrhetinic acid as potential inhibitors of cholinesterases.Bioorganic & medicinal chemistry, , Jul-01, Volume: 22, Issue:13, 2014
Synthesis of 4-[(diethylamino)methyl]-phenol derivatives as novel cholinesterase inhibitors with selectivity towards butyrylcholinesterase.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 20, Issue:11, 2010
Synthesis and biological evaluation of helicid analogues as novel acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Volume: 43, Issue:1, 2008
[no title available]MedChemComm, , Feb-01, Volume: 9, Issue:2, 2018
Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease.Journal of medicinal chemistry, , Jul-25, Volume: 56, Issue:14, 2013
Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , May-15, Volume: 194, 2020
Design, synthesis and evaluation of novel ferulic acid-memoquin hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 05-15, Volume: 26, Issue:10, 2016
Benzenediol-berberine hybrids: multifunctional agents for Alzheimer's disease.Bioorganic & medicinal chemistry, , Dec-01, Volume: 19, Issue:23, 2011
Synthesis, crystal structure and biological evaluation of some novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines.European journal of medicinal chemistry, , May-06, Volume: 78, 2014
Pd-Catalyzed Direct Diversification of Natural Anti-Alzheimer's Disease Drug: Synthesis and Biological Evaluation of Journal of natural products, , 08-27, Volume: 84, Issue:8, 2021
Design, synthesis and evaluation of new 4-arylthiazole-2-amine derivatives as acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , 03-15, Volume: 30, Issue:6, 2020
Tacrine-ferulic acid-nitric oxide (NO) donor trihybrids as potent, multifunctional acetyl- and butyrylcholinesterase inhibitors.Journal of medicinal chemistry, , May-10, Volume: 55, Issue:9, 2012
Benzofurans from Styrax agrestis as acetylcholinesterase inhibitors: structure-activity relationships and molecular modeling studies.Journal of natural products, , Oct-28, Volume: 74, Issue:10, 2011
Synthesis and evaluation of heterobivalent tacrine derivatives as potential multi-functional anti-Alzheimer agents.European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor.Journal of medicinal chemistry, , Nov-15, Volume: 50, Issue:23, 2007
Tacrines for Alzheimer's disease therapy. III. The PyridoTacrines.European journal of medicinal chemistry, , Mar-15, Volume: 166, 2019
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.Journal of medicinal chemistry, , Jul-22, Volume: 53, Issue:14, 2010
Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate.Bioorganic & medicinal chemistry letters, , May-01, Volume: 20, Issue:9, 2010
New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties.Bioorganic & medicinal chemistry, , Aug-15, Volume: 16, Issue:16, 2008
Novel bipharmacophoric inhibitors of the cholinesterases with affinity to the muscarinic receptors MMedChemComm, , Jun-01, Volume: 8, Issue:6, 2017
Novel tacrine-ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 23, Issue:24, 2013
Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy.Bioorganic & medicinal chemistry letters, , 02-01, Volume: 30, Issue:3, 2020
Design, synthesis and evaluation of novel 5,6,7-trimethoxyflavone-6-chlorotacrine hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 25, Issue:7, 2015
Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease.European journal of medicinal chemistry, , Oct-05, Volume: 158, 2018
Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.European journal of medicinal chemistry, , Mar-21, Volume: 75, 2014
Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's diJournal of medicinal chemistry, , Dec-22, Volume: 54, Issue:24, 2011
Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases.Journal of medicinal chemistry, , Volume: 32, Issue:2, 1989
Nonquaternary cholinesterase reactivators. 3. 3(5)-Substituted 1,2,4-oxadiazol-5(3)-aldoximes and 1,2,4-oxadiazole-5(3)-thiocarbohydroximates as reactivators of organophosphonate-inhibited eel and human acetylcholinesterase in vitro.Journal of medicinal chemistry, , Volume: 29, Issue:11, 1986