Proteins > Amine oxidase [flavin-containing] B
Page last updated: 2024-08-07 16:19:07
Amine oxidase [flavin-containing] B
An amine oxidase [flavin-containing] B that is encoded in the genome of human. [PRO:DNx, UniProtKB:P27338]
Synonyms
EC 1.4.3.4;
Monoamine oxidase type B;
MAO-B
Research
Bioassay Publications (280)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 1 (0.36) | 18.7374 |
| 1990's | 3 (1.07) | 18.2507 |
| 2000's | 30 (10.71) | 29.6817 |
| 2010's | 195 (69.64) | 24.3611 |
| 2020's | 51 (18.21) | 2.80 |
Compounds (165)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | Homo sapiens (human) | Ki | 390.0000 | 2 | 2 |
| 4'-bromoflavone | Homo sapiens (human) | Ki | 1.2600 | 1 | 2 |
| 7,8-dihydroxyflavone | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| 7-hydroxyflavanone | Homo sapiens (human) | IC50 | 13.0000 | 1 | 1 |
| azobenzene | Homo sapiens (human) | IC50 | 12.7800 | 1 | 2 |
| caffeine | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| caffeine | Homo sapiens (human) | Ki | 3,700.0000 | 2 | 2 |
| chelerythrine | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| ciglitazone | Homo sapiens (human) | IC50 | 0.2250 | 2 | 2 |
| clonidine | Homo sapiens (human) | Ki | 0.1000 | 1 | 1 |
| danthron | Homo sapiens (human) | IC50 | 58.7000 | 1 | 1 |
| donepezil | Homo sapiens (human) | IC50 | 17.7333 | 3 | 3 |
| emodin | Homo sapiens (human) | IC50 | 3.2400 | 1 | 1 |
| fentanyl | Homo sapiens (human) | Ki | 5.4620 | 1 | 1 |
| harmaline | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| phenelzine | Homo sapiens (human) | IC50 | 0.1430 | 1 | 1 |
| phenelzine | Homo sapiens (human) | Ki | 1.2345 | 3 | 4 |
| iproniazid | Homo sapiens (human) | IC50 | 5.9633 | 75 | 77 |
| vitamin k 3 | Homo sapiens (human) | Ki | 0.4000 | 1 | 1 |
| 3,7-bis(dimethylamino)phenothiazin-5-ium | Homo sapiens (human) | IC50 | 4.3700 | 1 | 1 |
| moclobemide | Homo sapiens (human) | IC50 | 560.3943 | 6 | 7 |
| moclobemide | Homo sapiens (human) | Ki | 10.9555 | 9 | 11 |
| clorgyline | Homo sapiens (human) | IC50 | 178.5708 | 76 | 79 |
| quinone | Homo sapiens (human) | IC50 | 10.2000 | 1 | 1 |
| pargyline | Homo sapiens (human) | IC50 | 0.5031 | 29 | 29 |
| pargyline | Homo sapiens (human) | Ki | 0.6233 | 3 | 3 |
| pioglitazone | Homo sapiens (human) | IC50 | 0.2980 | 2 | 2 |
| pioglitazone | Homo sapiens (human) | Ki | 0.3234 | 3 | 3 |
| primaquine | Homo sapiens (human) | IC50 | 94.5000 | 1 | 1 |
| raloxifene | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| carbamylhydrazine | Homo sapiens (human) | IC50 | 3.3534 | 2 | 2 |
| vorinostat | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 2-phenylcyclopropan-1-amine | Homo sapiens (human) | IC50 | 4.9750 | 2 | 2 |
| troglitazone | Homo sapiens (human) | IC50 | 2.0700 | 2 | 2 |
| troglitazone | Homo sapiens (human) | Ki | 9.5000 | 1 | 1 |
| zonisamide | Homo sapiens (human) | Ki | 3.1000 | 1 | 1 |
| dextroamphetamine | Homo sapiens (human) | Ki | 280.0000 | 1 | 1 |
| p-dimethylaminoazobenzene | Homo sapiens (human) | IC50 | 2.3273 | 1 | 2 |
| ficusin | Homo sapiens (human) | IC50 | 60.0000 | 1 | 1 |
| alizarin | Homo sapiens (human) | IC50 | 60.0000 | 1 | 1 |
| purpurin | Homo sapiens (human) | IC50 | 40.0667 | 3 | 3 |
| 1,4-dihydroxyanthraquinone | Homo sapiens (human) | IC50 | 110.0000 | 1 | 1 |
| 2,6-dihydroxyanthraquinone | Homo sapiens (human) | IC50 | 5.6200 | 1 | 1 |
| phthalimide | Homo sapiens (human) | IC50 | 134.0000 | 1 | 1 |
| phthalide | Homo sapiens (human) | IC50 | 28.6000 | 1 | 1 |
| aminacrine | Homo sapiens (human) | IC50 | 112.0000 | 1 | 1 |
| 1,2,3,4-tetrahydroisoquinoline | Homo sapiens (human) | Ki | 15.0000 | 1 | 1 |
| isatin | Homo sapiens (human) | IC50 | 41.6612 | 14 | 14 |
| isatin | Homo sapiens (human) | Ki | 4.0873 | 7 | 10 |
| xanthenes | Homo sapiens (human) | IC50 | 7.4200 | 1 | 1 |
| 1,4-naphthoquinone | Homo sapiens (human) | Ki | 1.5000 | 1 | 1 |
| 4-aminodiphenyl ether | Homo sapiens (human) | IC50 | 303.0000 | 1 | 1 |
| 4-aminodiphenyl ether | Homo sapiens (human) | Ki | 131.0000 | 1 | 1 |
| n-phenethylpiperidine | Homo sapiens (human) | IC50 | 761.5000 | 1 | 1 |
| phenylbenzoquinone | Homo sapiens (human) | IC50 | 7.8700 | 1 | 1 |
| aloe emodin | Homo sapiens (human) | IC50 | 21.9000 | 1 | 1 |
| flavanone | Homo sapiens (human) | IC50 | 2.8700 | 1 | 1 |
| 4-chromone | Homo sapiens (human) | IC50 | 54.9000 | 1 | 1 |
| angelicin | Homo sapiens (human) | IC50 | 2.7300 | 1 | 1 |
| flavone | Homo sapiens (human) | Ki | 1.7800 | 1 | 2 |
| coumarin-3-carboxylic acid | Homo sapiens (human) | IC50 | 0.0174 | 1 | 1 |
| 1,2-diaminoanthraquinone | Homo sapiens (human) | IC50 | 2.4100 | 1 | 1 |
| tranylcypromine | Homo sapiens (human) | IC50 | 5.0762 | 8 | 8 |
| tranylcypromine | Homo sapiens (human) | Ki | 16.0000 | 2 | 2 |
| 5-nitroindazole | Homo sapiens (human) | IC50 | 2.5000 | 1 | 1 |
| (1S,2R)-tranylcypromine | Homo sapiens (human) | IC50 | 1.2200 | 3 | 4 |
| selegiline | Homo sapiens (human) | IC50 | 1.5074 | 96 | 97 |
| selegiline | Homo sapiens (human) | Ki | 1.6305 | 15 | 17 |
| selegiline hydrochloride, (r)-isomer | Homo sapiens (human) | IC50 | 0.0067 | 2 | 2 |
| toloxatone | Homo sapiens (human) | IC50 | 80.0000 | 1 | 1 |
| toloxatone | Homo sapiens (human) | Ki | 15.0000 | 1 | 1 |
| idazoxan | Homo sapiens (human) | Ki | 0.0190 | 2 | 2 |
| norharman | Homo sapiens (human) | Ki | 1.1600 | 2 | 2 |
| isoimperatorin | Homo sapiens (human) | IC50 | 60.0000 | 1 | 1 |
| rilmenidine | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| 9-chloroacridine | Homo sapiens (human) | IC50 | 91.9000 | 1 | 1 |
| lazabemide | Homo sapiens (human) | IC50 | 0.0770 | 20 | 20 |
| lazabemide | Homo sapiens (human) | Ki | 0.0342 | 5 | 5 |
| thioxolone | Homo sapiens (human) | IC50 | 9.5700 | 1 | 1 |
| xanthydrol | Homo sapiens (human) | IC50 | 92.0000 | 1 | 1 |
| 3-acetylcoumarin | Homo sapiens (human) | IC50 | 14.4500 | 1 | 1 |
| 4'-methoxyflavone | Homo sapiens (human) | IC50 | 27.8700 | 1 | 1 |
| 4'-methoxyflavone | Homo sapiens (human) | Ki | 2.2200 | 1 | 2 |
| rosiglitazone | Homo sapiens (human) | IC50 | 0.8320 | 2 | 2 |
| rosiglitazone | Homo sapiens (human) | Ki | 4.2000 | 1 | 1 |
| 2,3,6-trimethyl-1,4-naphthoquinone | Homo sapiens (human) | Ki | 3.0000 | 1 | 1 |
| inermin | Homo sapiens (human) | IC50 | 0.6800 | 1 | 1 |
| inermin | Homo sapiens (human) | Ki | 0.0540 | 1 | 1 |
| oxoglaucine | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| 3,7-dimethyl-1-propargylxanthine | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| benzo(g)isoquinoline-5,10-dione | Homo sapiens (human) | IC50 | 4.2800 | 1 | 1 |
| 4'-methoxyflavanone | Homo sapiens (human) | IC50 | 2.2000 | 1 | 1 |
| cinnabarinic acid | Homo sapiens (human) | IC50 | 65.0000 | 1 | 1 |
| safinamide | Homo sapiens (human) | IC50 | 6.1529 | 40 | 42 |
| safinamide | Homo sapiens (human) | Ki | 0.1544 | 6 | 6 |
| 2'-methoxyflavone | Homo sapiens (human) | Ki | 2.4350 | 1 | 2 |
| 1-(1,3-benzodioxol-5-yl)-3-(1-piperidinyl)-1-propanone | Homo sapiens (human) | IC50 | 3.4300 | 1 | 1 |
| 4'-chloroflavone | Homo sapiens (human) | Ki | 2.2500 | 1 | 2 |
| rhodioloside | Homo sapiens (human) | IC50 | 0.8100 | 1 | 1 |
| rhodioloside | Homo sapiens (human) | Ki | 0.9200 | 1 | 1 |
| harmalan | Homo sapiens (human) | Ki | 0.1480 | 1 | 1 |
| corydalmine | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| 2'-hydroxyflavone | Homo sapiens (human) | Ki | 3.2500 | 1 | 2 |
| corynoline | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| Chromone-3-carboxylic acid | Homo sapiens (human) | IC50 | 0.0240 | 2 | 2 |
| 1-acetyl-3,5-diphenyl-4,5-dihydro-(1h)-pyrazole | Homo sapiens (human) | IC50 | 20.5045 | 1 | 2 |
| tv3326 | Homo sapiens (human) | IC50 | 50.9167 | 6 | 6 |
| tv3326 | Homo sapiens (human) | Ki | 217.6667 | 2 | 3 |
| 4'-hydroxyflavone | Homo sapiens (human) | Ki | 3.0550 | 1 | 2 |
| naringenin | Homo sapiens (human) | IC50 | 288.0000 | 1 | 1 |
| linezolid | Homo sapiens (human) | IC50 | 9.5500 | 2 | 2 |
| farnesol | Homo sapiens (human) | Ki | 430.0714 | 1 | 7 |
| resveratrol | Homo sapiens (human) | IC50 | 22.2367 | 3 | 3 |
| u 100480 | Homo sapiens (human) | IC50 | 0.7000 | 1 | 1 |
| 8-prenylnaringenin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 3'-methoxyflavone | Homo sapiens (human) | Ki | 1.4250 | 1 | 2 |
| chalcone | Homo sapiens (human) | IC50 | 471.7867 | 3 | 3 |
| chalcone | Homo sapiens (human) | Ki | 0.0560 | 1 | 1 |
| piperine | Homo sapiens (human) | IC50 | 0.7665 | 2 | 2 |
| 1,4-diphenylbutadiene | Homo sapiens (human) | Ki | 0.3003 | 2 | 2 |
| 4'-methoxychalcone | Homo sapiens (human) | IC50 | 0.4710 | 1 | 1 |
| 4'-methoxychalcone | Homo sapiens (human) | Ki | 0.0219 | 1 | 1 |
| N-[3-(4-morpholinyl)propyl]-2-oxo-1-benzopyran-3-carboxamide | Homo sapiens (human) | IC50 | 13.4600 | 1 | 1 |
| 3',4'-dimethoxyflavone | Homo sapiens (human) | Ki | 2.4800 | 1 | 2 |
| ethyl ferulate | Homo sapiens (human) | IC50 | 6.7000 | 1 | 1 |
| 7-methoxy-2-oxo-1-benzopyran-3-carboxylic acid ethyl ester | Homo sapiens (human) | IC50 | 23.4600 | 1 | 1 |
| curcumin | Homo sapiens (human) | IC50 | 2.5733 | 3 | 3 |
| curcumin | Homo sapiens (human) | Ki | 21.5000 | 1 | 1 |
| 3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione | Homo sapiens (human) | IC50 | 0.0820 | 3 | 3 |
| 4-aminostilbene | Homo sapiens (human) | IC50 | 6.3400 | 1 | 1 |
| 4-aminostilbene | Homo sapiens (human) | Ki | 2.7300 | 1 | 1 |
| cis-resveratrol | Homo sapiens (human) | IC50 | 61.0000 | 1 | 1 |
| 3-acetyl-7-methoxycoumarin | Homo sapiens (human) | IC50 | 15.4000 | 1 | 1 |
| (1R,2S)-tranylcypromine hydrochloride | Homo sapiens (human) | IC50 | 2.8117 | 3 | 3 |
| N5-(2-chloro-6-phenoxybenzyl)-1H-1,2,4-triazole-3,5-diamine | Homo sapiens (human) | IC50 | 150.0000 | 2 | 2 |
| mdl 72527 | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| azilect | Homo sapiens (human) | IC50 | 0.0250 | 2 | 2 |
| rasagiline | Homo sapiens (human) | IC50 | 3.9312 | 54 | 56 |
| rasagiline | Homo sapiens (human) | Ki | 2.5246 | 7 | 9 |
| 2-(2-benzofuranyl)-2-imidazoline | Homo sapiens (human) | Ki | 14.2000 | 3 | 3 |
| bakuchicin | Homo sapiens (human) | IC50 | 5.4400 | 1 | 1 |
| 2',3-dihydroxychalcone | Homo sapiens (human) | IC50 | 1.1000 | 1 | 1 |
| 7-methoxy-2-(4-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one | Homo sapiens (human) | IC50 | 7.1800 | 1 | 1 |
| quercetin | Homo sapiens (human) | IC50 | 64.3300 | 2 | 2 |
| biochanin a | Homo sapiens (human) | IC50 | 0.4000 | 1 | 1 |
| formononetin | Homo sapiens (human) | IC50 | 25.8000 | 1 | 1 |
| acacetin | Homo sapiens (human) | IC50 | 0.0490 | 1 | 1 |
| acacetin | Homo sapiens (human) | Ki | 0.0490 | 1 | 1 |
| apigenin | Homo sapiens (human) | IC50 | 6.9600 | 2 | 2 |
| luteolin | Homo sapiens (human) | IC50 | 59.7000 | 1 | 1 |
| scopoletin | Homo sapiens (human) | IC50 | 60.0000 | 1 | 1 |
| hymecromone | Homo sapiens (human) | IC50 | 80.4100 | 1 | 1 |
| harmine | Homo sapiens (human) | Ki | 60.4110 | 2 | 2 |
| genistein | Homo sapiens (human) | IC50 | 3.9333 | 3 | 3 |
| gardenia yellow | Homo sapiens (human) | IC50 | 128.0000 | 1 | 1 |
| hispidol | Homo sapiens (human) | IC50 | 2.4500 | 1 | 1 |
| hispidol | Homo sapiens (human) | Ki | 0.5100 | 1 | 1 |
| sulfuretin | Homo sapiens (human) | IC50 | 80.0000 | 1 | 1 |
| chrysin | Homo sapiens (human) | IC50 | 1.6000 | 1 | 1 |
| galangin | Homo sapiens (human) | IC50 | 3.6500 | 1 | 1 |
| daidzein | Homo sapiens (human) | IC50 | 14.0000 | 2 | 2 |
| 7-hydroxyflavone | Homo sapiens (human) | IC50 | 0.1200 | 1 | 1 |
| 4',7-dihydroxyflavone | Homo sapiens (human) | IC50 | 0.0300 | 1 | 1 |
| 4'-hydroxychalcone | Homo sapiens (human) | IC50 | 2.3410 | 2 | 2 |
| as 605240 | Homo sapiens (human) | IC50 | 13.0000 | 2 | 2 |
| istradefylline | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| istradefylline | Homo sapiens (human) | Ki | 0.0270 | 1 | 1 |
| osthenol | Homo sapiens (human) | IC50 | 60.0000 | 1 | 1 |
| 8-(3-chlorostyryl)caffeine | Homo sapiens (human) | IC50 | 0.1603 | 4 | 4 |
| 8-(3-chlorostyryl)caffeine | Homo sapiens (human) | Ki | 0.1303 | 6 | 6 |
| 4'-chloroaurone | Homo sapiens (human) | IC50 | 0.3050 | 1 | 1 |
| geiparvarin | Homo sapiens (human) | IC50 | 0.1445 | 1 | 1 |
| derricidin | Homo sapiens (human) | IC50 | 4,669.2602 | 3 | 4 |
| ciproxifan | Homo sapiens (human) | IC50 | 2.0333 | 3 | 3 |
| mofegiline | Homo sapiens (human) | IC50 | 0.0060 | 2 | 2 |
| mofegiline | Homo sapiens (human) | Ki | 0.0280 | 1 | 1 |
| tracizoline | Homo sapiens (human) | Ki | 0.0019 | 2 | 2 |
| pf9601n | Homo sapiens (human) | IC50 | 0.0041 | 1 | 1 |
| delta-viniferin | Homo sapiens (human) | IC50 | 2.3900 | 1 | 1 |
| tedizolid | Homo sapiens (human) | IC50 | 5.7000 | 1 | 1 |
| cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl]hydrazone | Homo sapiens (human) | IC50 | 0.2625 | 1 | 2 |
| 5-(2,5-difluorophenyl)-N-(2,6-dimethylphenyl)-2-furancarboxamide | Homo sapiens (human) | IC50 | 25.0000 | 1 | 0 |
| 5-(2,5-dichlorophenyl)-N-(2,6-dimethoxyphenyl)-2-furancarboxamide | Homo sapiens (human) | IC50 | 10.5400 | 1 | 0 |
| 5-(2,5-dichlorophenyl)-N-[2,6-di(propan-2-yl)phenyl]-2-furancarboxamide | Homo sapiens (human) | IC50 | 25.0000 | 1 | 0 |
| 5-(2,5-dichlorophenyl)-N-(2,6-diethylphenyl)-2-furancarboxamide | Homo sapiens (human) | IC50 | 25.0000 | 1 | 0 |
| N-(2,6-dimethylphenyl)-5-(4-methyl-3-thiophenyl)-2-furancarboxamide | Homo sapiens (human) | IC50 | 25.0000 | 1 | 0 |
| 1-(4-methyl-1-piperazinyl)-2-[[(1R,2S)-2-(4-phenylmethoxyphenyl)cyclopropyl]amino]ethanone | Homo sapiens (human) | IC50 | 2.7850 | 1 | 1 |
| ass234 | Homo sapiens (human) | IC50 | 0.8093 | 6 | 6 |
| gsk2879552 | Homo sapiens (human) | IC50 | 100.0000 | 3 | 3 |
| methylaplysinopsin | Homo sapiens (human) | IC50 | 9.0170 | 1 | 1 |
| aplysinopsin | Homo sapiens (human) | IC50 | 10.0170 | 1 | 1 |
Drugs with Activation Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| tyramine | Homo sapiens (human) | Km | 104.7000 | 1 | 1 |
| tranylcypromine | Homo sapiens (human) | Kinact | 37.3000 | 1 | 1 |
[no title available]Bioorganic & medicinal chemistry, , 11-01, Volume: 24, Issue:21, 2016
New Frontiers in Selective Human MAO-B Inhibitors.Journal of medicinal chemistry, , Sep-10, Volume: 58, Issue:17, 2015
Inhibition of monoamine oxidase by (E)-styrylisatin analogues.Bioorganic & medicinal chemistry letters, , May-01, Volume: 19, Issue:9, 2009
Design, synthesis, in-vitro, in-vivo and ex-vivo pharmacology of thiazolidine-2,4-dione derivatives as selective and reversible monoamine oxidase-B inhibitors.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 76, 2022
Identification of novel monoamine oxidase B inhibitors by structure-based virtual screening.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 20, Issue:17, 2010
Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy.European journal of medicinal chemistry, , Apr-05, Volume: 233, 2022
Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation.European journal of medicinal chemistry, , Oct-04, Volume: 121, 2016
Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.European journal of medicinal chemistry, , Mar-21, Volume: 75, 2014
Isolation of Acacetin from Calea urticifolia with Inhibitory Properties against Human Monoamine Oxidase-A and -B.Journal of natural products, , 10-28, Volume: 79, Issue:10, 2016
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.Bioorganic & medicinal chemistry, , Feb-15, Volume: 23, Issue:4, 2015
A selective phenelzine analogue inhibitor of histone demethylase LSD1.ACS chemical biology, , Jun-20, Volume: 9, Issue:6, 2014
Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy.European journal of medicinal chemistry, , Apr-05, Volume: 233, 2022
Synthesis and human monoamine oxidase inhibitory activity of novel C2-, C3- and C4-substituted phthalonitriles.Bioorganic & medicinal chemistry letters, , 10-15, Volume: 74, 2022
Development of MAO-A and 5-HTJournal of medicinal chemistry, , 10-13, Volume: 65, Issue:19, 2022
Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades.Journal of medicinal chemistry, , 03-24, Volume: 65, Issue:6, 2022
Design, synthesis and evaluation of novel dimethylamino chalcone-O-alkylamines derivatives as potential multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Apr-15, Volume: 216, 2021
Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 04-01, Volume: 35, 2021
Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer's disease.European journal of medicinal chemistry, , Sep-15, Volume: 202, 2020
Design, synthesis and evaluation of flurbiprofen-clioquinol hybrids as multitarget-directed ligands against Alzheimer's disease.Bioorganic & medicinal chemistry, , 04-01, Volume: 28, Issue:7, 2020
Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties.European journal of medicinal chemistry, , Mar-15, Volume: 190, 2020
Chromone and donepezil hybrids as new multipotent cholinesterase and monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.RSC medicinal chemistry, , Feb-01, Volume: 11, Issue:2, 2020
Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease.Bioorganic & medicinal chemistry, , 04-15, Volume: 28, Issue:8, 2020
Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Sep-15, Volume: 178, 2019
Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease.European journal of medicinal chemistry, , Feb-01, Volume: 163, 2019
The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 10-01, Volume: 29, Issue:19, 2019
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties.European journal of medicinal chemistry, , Sep-05, Volume: 157, 2018
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.European journal of medicinal chemistry, , Aug-05, Volume: 156, 2018
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.Bioorganic & medicinal chemistry, , 05-01, Volume: 26, Issue:8, 2018
Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment.Bioorganic & medicinal chemistry, , 03-01, Volume: 26, Issue:5, 2018
Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer's disease.Bioorganic chemistry, , Volume: 71, 2017
Synthesis and pharmacological evaluation of novel chromone derivatives as balanced multifunctional agents against Alzheimer's disease.Bioorganic & medicinal chemistry, , 07-15, Volume: 25, Issue:14, 2017
Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 02-01, Volume: 25, Issue:3, 2017
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 27, Issue:22, 2017
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jan-27, Volume: 126, 2017
Anisucoumaramide, a Bioactive Coumarin from Clausena anisum-olens.Journal of natural products, , 04-28, Volume: 80, Issue:4, 2017
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 06-15, Volume: 25, Issue:12, 2017
Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
Synthesis and evaluation of small molecules bearing a benzyloxy substituent as novel and potent monoamine oxidase inhibitors.MedChemComm, , Feb-01, Volume: 8, Issue:2, 2017
Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 27, Issue:22, 2017
Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.Bioorganic & medicinal chemistry, , 03-15, Volume: 25, Issue:6, 2017
Synthesis and structure-activity relationship study of novel 3-heteroarylcoumarins based on pyridazine scaffold as selective MAO-B inhibitors.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 27, Issue:4, 2017
Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties.Bioorganic & medicinal chemistry, , 01-15, Volume: 25, Issue:2, 2017
Neuroprotective effects of benzyloxy substituted small molecule monoamine oxidase B inhibitors in Parkinson's disease.Bioorganic & medicinal chemistry, , 11-15, Volume: 24, Issue:22, 2016
Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 05-15, Volume: 24, Issue:10, 2016
New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties.European journal of medicinal chemistry, , Oct-04, Volume: 121, 2016
(E)-3-Heteroarylidenechroman-4-ones as potent and selective monoamine oxidase-B inhibitors.European journal of medicinal chemistry, , Jul-19, Volume: 117, 2016
Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , Apr-01, Volume: 24, Issue:7, 2016
Drug design, synthesis, in vitro and in silico evaluation of selective monoaminoxidase B inhibitors based on 3-acetyl-2-dichlorophenyl-5-aryl-2,3-dihydro-1,3,4-oxadiazole chemical scaffold.European journal of medicinal chemistry, , Jan-27, Volume: 108, 2016
Multifunctional coumarin derivatives: monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer's disease.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 25, Issue:3, 2015
Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.European journal of medicinal chemistry, , May-05, Volume: 95, 2015
New 2H-chromene-3-carboxamide derivatives: design, synthesis and use as inhibitors of hMAO.European journal of medicinal chemistry, , Jun-10, Volume: 80, 2014
Identification of the stereochemical requirements in the 4-aryl-2-cycloalkylidenhydrazinylthiazole scaffold for the design of selective human monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry, , May-15, Volume: 22, Issue:10, 2014
New coumarin derivatives: design, synthesis and use as inhibitors of hMAO.Bioorganic & medicinal chemistry, , Jul-15, Volume: 22, Issue:14, 2014
1,5-Diphenylpenta-2,4-dien-1-ones as potent and selective monoamine oxidase-B inhibitors.European journal of medicinal chemistry, , Volume: 59, 2013
Design, synthesis, and in vitro hMAO-B inhibitory evaluation of some 1-methyl-3,5-diphenyl-4,5-dihydro-1H-pyrazoles.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 23, Issue:18, 2013
Novel (coumarin-3-yl)carbamates as selective MAO-B inhibitors: synthesis, in vitro and in vivo assays, theoretical evaluation of ADME properties and docking study.European journal of medicinal chemistry, , Volume: 63, 2013
Synthesis and biological assessment of novel 2-thiazolylhydrazones and computational analysis of their recognition by monoamine oxidase B.European journal of medicinal chemistry, , Volume: 48, 2012
Recent advances in the development of selective human MAO-B inhibitors: (hetero)arylidene-(4-substituted-thiazol-2-yl)hydrazines.European journal of medicinal chemistry, , Volume: 58, 2012
Hydroxycoumarins as selective MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 22, Issue:1, 2012
Homoisoflavonoids: natural scaffolds with potent and selective monoamine oxidase-B inhibition properties.Journal of medicinal chemistry, , Apr-14, Volume: 54, Issue:7, 2011
Synthesis and selective human monoamine oxidase inhibition of 3-carbonyl, 3-acyl, and 3-carboxyhydrazido coumarin derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:10, 2011
MAO inhibitory activity modulation: 3-Phenylcoumarins versus 3-benzoylcoumarins.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 21, Issue:14, 2011
2D MI-DRAGON: a new predictor for protein-ligands interactions and theoretic-experimental studies of US FDA drug-target network, oxoisoaporphine inhibitors for MAO-A and human parasite proteins.European journal of medicinal chemistry, , Volume: 46, Issue:12, 2011
Chromone 3-phenylcarboxamides as potent and selective MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Synthesis, human monoamine oxidase inhibitory activity and molecular docking studies of 3-heteroarylcoumarin derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:4, 2011
Synthesis and study of a series of 3-arylcoumarins as potent and selective monoamine oxidase B inhibitors.Journal of medicinal chemistry, , Oct-27, Volume: 54, Issue:20, 2011
Chromone, a privileged scaffold for the development of monoamine oxidase inhibitors.Journal of medicinal chemistry, , Jul-28, Volume: 54, Issue:14, 2011
Synthesis of new 3-aryl-4,5-dihydropyrazole-1-carbothioamide derivatives. An investigation on their ability to inhibit monoamine oxidase.European journal of medicinal chemistry, , Volume: 45, Issue:10, 2010
A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors.Bioorganic & medicinal chemistry, , Volume: 18, Issue:3, 2010
Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry, , Jul-15, Volume: 18, Issue:14, 2010
Synthesis, stereochemical separation, and biological evaluation of selective inhibitors of human MAO-B: 1-(4-arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazines.Journal of medicinal chemistry, , Sep-09, Volume: 53, Issue:17, 2010
Investigations on the 2-thiazolylhydrazyne scaffold: synthesis and molecular modeling of selective human monoamine oxidase inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010
Synthesis and inhibitory activity against human monoamine oxidase of N1-thiocarbamoyl-3,5-di(hetero)aryl-4,5-dihydro-(1H)-pyrazole derivatives.European journal of medicinal chemistry, , Volume: 45, Issue:2, 2010
Synthesis and molecular modelling studies of prenylated pyrazolines as MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 20, Issue:22, 2010
New halogenated 3-phenylcoumarins as potent and selective MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 20, Issue:17, 2010
Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B.Bioorganic & medicinal chemistry letters, , May-01, Volume: 20, Issue:9, 2010
A new series of 3-phenylcoumarins as potent and selective MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 19, Issue:12, 2009
Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins.Journal of medicinal chemistry, , Apr-09, Volume: 52, Issue:7, 2009
Chalcones: a valid scaffold for monoamine oxidases inhibitors.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Synthesis and evaluation of 6-methyl-3-phenylcoumarins as potent and selective MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 19, Issue:17, 2009
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.Journal of medicinal chemistry, , Nov-13, Volume: 51, Issue:21, 2008
Synthesis, stereochemical identification, and selective inhibitory activity against human monoamine oxidase-B of 2-methylcyclohexylidene-(4-arylthiazol-2-yl)hydrazones.Journal of medicinal chemistry, , Aug-28, Volume: 51, Issue:16, 2008
Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades.Journal of medicinal chemistry, , 03-24, Volume: 65, Issue:6, 2022
New 2-Pyrazoline and Hydrazone Derivatives as Potent and Selective Monoamine Oxidase A Inhibitors.Journal of medicinal chemistry, , 02-25, Volume: 64, Issue:4, 2021
Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties.European journal of medicinal chemistry, , Mar-15, Volume: 190, 2020
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.European journal of medicinal chemistry, , Aug-05, Volume: 156, 2018
[no title available]MedChemComm, , Jul-01, Volume: 9, Issue:7, 2018
MAO inhibitory activity of bromo-2-phenylbenzofurans: synthesis, MedChemComm, , Sep-01, Volume: 8, Issue:9, 2017
Monoamine Oxidase Inhibitory Activity of Novel Pyrazoline Analogues: Curcumin Based Design and Synthesis.ACS medicinal chemistry letters, , Jan-14, Volume: 7, Issue:1, 2016
New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties.European journal of medicinal chemistry, , Oct-04, Volume: 121, 2016
Development of fluorinated methoxylated chalcones as selective monoamine oxidase-B inhibitors: Synthesis, biochemistry and molecular docking studies.Bioorganic chemistry, , Volume: 62, 2015
Monoamine oxidase inhibitory activity of 2-aryl-4H-chromen-4-ones.Bioorganic chemistry, , Volume: 58, 2015
Synthesis of some novel hydrazone and 2-pyrazoline derivatives: monoamine oxidase inhibitory activities and docking studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 24, Issue:15, 2014
Monoamine oxidase inhibitory activity of 3,5-biaryl-4,5-dihydro-1H-pyrazole-1-carboxylate derivatives.European journal of medicinal chemistry, , Volume: 69, 2013
Pyrazoline based MAO inhibitors: synthesis, biological evaluation and SAR studies.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 21, Issue:14, 2011
Chalcones: a valid scaffold for monoamine oxidases inhibitors.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Design, synthesis, and biological activities of pyrrolylethanoneamine derivatives, a novel class of monoamine oxidases inhibitors.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy.European journal of medicinal chemistry, , Apr-05, Volume: 233, 2022
4-Oxoquinolines and monoamine oxidase: When tautomerism matters.European journal of medicinal chemistry, , Mar-05, Volume: 213, 2021
Synthesis and biological evaluation of 3-styrylchromone derivatives as selective monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry, , 07-15, Volume: 42, 2021
Design, synthesis and evaluation of novel dimethylamino chalcone-O-alkylamines derivatives as potential multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Apr-15, Volume: 216, 2021
Novel 1-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-indene-4-thiol derivatives as potent selective human monoamine oxidase B inhibitors: Design, SAR development, and biological evaluation.Bioorganic & medicinal chemistry letters, , 07-01, Volume: 43, 2021
Mapping Chromone-3-Phenylcarboxamide Pharmacophore: Journal of medicinal chemistry, , 08-12, Volume: 64, Issue:15, 2021
Pyrimido[1,2-b]indazole derivatives: Selective inhibitors of human monoamine oxidase B with neuroprotective activity.European journal of medicinal chemistry, , Jan-01, Volume: 209, 2021
Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 04-01, Volume: 35, 2021
[no title available]Journal of medicinal chemistry, , 02-13, Volume: 63, Issue:3, 2020
Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies.European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer's disease.European journal of medicinal chemistry, , Sep-15, Volume: 202, 2020
Design, synthesis and evaluation of flurbiprofen-clioquinol hybrids as multitarget-directed ligands against Alzheimer's disease.Bioorganic & medicinal chemistry, , 04-01, Volume: 28, Issue:7, 2020
Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease.Bioorganic & medicinal chemistry, , 04-15, Volume: 28, Issue:8, 2020
Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , May-15, Volume: 194, 2020
Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure.Bioorganic & medicinal chemistry letters, , 04-15, Volume: 29, Issue:8, 2019
Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity.Bioorganic & medicinal chemistry letters, , 03-15, Volume: 29, Issue:6, 2019
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors.European journal of medicinal chemistry, , Jan-01, Volume: 161, 2019
Discovery of novel 2,3-dihydro-1H-inden-1-amine derivatives as selective monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry letters, , 05-01, Volume: 29, Issue:9, 2019
Selected aryl thiosemicarbazones as a new class of multi-targeted monoamine oxidase inhibitors.MedChemComm, , Nov-01, Volume: 9, Issue:11, 2018
Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.European journal of medicinal chemistry, , Oct-05, Volume: 158, 2018
Design, synthesis and bioevalucation of novel 2,3-dihydro-1H-inden-1-amine derivatives as potent and selective human monoamine oxidase B inhibitors based on rasagiline.European journal of medicinal chemistry, , Feb-10, Volume: 145, 2018
Development of Novel Monoamine Oxidase-B (MAO-B) Inhibitors with Reduced Blood-Brain Barrier Permeability for the Potential Management of Noncentral Nervous System (CNS) Diseases.Journal of medicinal chemistry, , 08-23, Volume: 61, Issue:16, 2018
Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B inhibitors toward Parkinson's disease therapy.Bioorganic & medicinal chemistry, , 01-01, Volume: 26, Issue:1, 2018
Selective inhibition of monoamine oxidase A by hispidol.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 28, Issue:4, 2018
Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents.European journal of medicinal chemistry, , Jan-01, Volume: 143, 2018
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.Bioorganic & medicinal chemistry, , 05-01, Volume: 26, Issue:8, 2018
Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment.Bioorganic & medicinal chemistry, , 03-01, Volume: 26, Issue:5, 2018
Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer's disease.Bioorganic chemistry, , Volume: 71, 2017
Symmetrical aryl linked bis-iminothiazolidinones as new chemical entities for the inhibition of monoamine oxidases: Synthesis, in vitro biological evaluation and molecular modelling analysis.Bioorganic chemistry, , Volume: 70, 2017
MAO inhibitory activity of bromo-2-phenylbenzofurans: synthesis, MedChemComm, , Sep-01, Volume: 8, Issue:9, 2017
Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 02-01, Volume: 25, Issue:3, 2017
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jan-27, Volume: 126, 2017
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 06-15, Volume: 25, Issue:12, 2017
N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.Bioorganic & medicinal chemistry, , 01-15, Volume: 25, Issue:2, 2017
Pyrazolobenzothiazine-based carbothioamides as new structural leads for the inhibition of monoamine oxidases: design, synthesis, MedChemComm, , Feb-01, Volume: 8, Issue:2, 2017
Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 27, Issue:22, 2017
Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.Bioorganic & medicinal chemistry, , 03-15, Volume: 25, Issue:6, 2017
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 27, Issue:4, 2017
Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties.Bioorganic & medicinal chemistry, , 01-15, Volume: 25, Issue:2, 2017
Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents.Journal of medicinal chemistry, , 07-28, Volume: 59, Issue:14, 2016
Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation.European journal of medicinal chemistry, , Oct-04, Volume: 121, 2016
Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 05-15, Volume: 24, Issue:10, 2016
(E)-3-Heteroarylidenechroman-4-ones as potent and selective monoamine oxidase-B inhibitors.European journal of medicinal chemistry, , Jul-19, Volume: 117, 2016
Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors.Journal of medicinal chemistry, , 06-23, Volume: 59, Issue:12, 2016
Potent selective monoamine oxidase B inhibition by maackiain, a pterocarpan from the roots of Sophora flavescens.Bioorganic & medicinal chemistry letters, , 10-01, Volume: 26, Issue:19, 2016
Drug design, synthesis, in vitro and in silico evaluation of selective monoaminoxidase B inhibitors based on 3-acetyl-2-dichlorophenyl-5-aryl-2,3-dihydro-1,3,4-oxadiazole chemical scaffold.European journal of medicinal chemistry, , Jan-27, Volume: 108, 2016
Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry, , 10-15, Volume: 24, Issue:20, 2016
Novel 2H-chromen-2-one derivatives of resveratrol: Design, synthesis, modeling and use as human monoamine oxidase inhibitors.European journal of medicinal chemistry, , Oct-20, Volume: 103, 2015
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.Journal of medicinal chemistry, , Jul-23, Volume: 58, Issue:14, 2015
Synthesis of a series of unsaturated ketone derivatives as selective and reversible monoamine oxidase inhibitors.Bioorganic & medicinal chemistry, , Oct-01, Volume: 23, Issue:19, 2015
Evaluation of Homobivalent Carbolines as Designed Multiple Ligands for the Treatment of Neurodegenerative Disorders.Journal of medicinal chemistry, , Aug-27, Volume: 58, Issue:16, 2015
N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.Journal of medicinal chemistry, , Dec-26, Volume: 57, Issue:24, 2014
Identification of the stereochemical requirements in the 4-aryl-2-cycloalkylidenhydrazinylthiazole scaffold for the design of selective human monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry, , May-15, Volume: 22, Issue:10, 2014
1,5-Diphenylpenta-2,4-dien-1-ones as potent and selective monoamine oxidase-B inhibitors.European journal of medicinal chemistry, , Volume: 59, 2013
Design, synthesis, and in vitro hMAO-B inhibitory evaluation of some 1-methyl-3,5-diphenyl-4,5-dihydro-1H-pyrazoles.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 23, Issue:18, 2013
Synthesis and biological assessment of novel 2-thiazolylhydrazones and computational analysis of their recognition by monoamine oxidase B.European journal of medicinal chemistry, , Volume: 48, 2012
Recent advances in the development of selective human MAO-B inhibitors: (hetero)arylidene-(4-substituted-thiazol-2-yl)hydrazines.European journal of medicinal chemistry, , Volume: 58, 2012
Homoisoflavonoids: natural scaffolds with potent and selective monoamine oxidase-B inhibition properties.Journal of medicinal chemistry, , Apr-14, Volume: 54, Issue:7, 2011
Synthesis of three novel fluorine-18 labeled analogues of L-deprenyl for positron emission tomography (PET) studies of monoamine oxidase B (MAO-B).Journal of medicinal chemistry, , Oct-27, Volume: 54, Issue:20, 2011
Synthesis and selective human monoamine oxidase inhibition of 3-carbonyl, 3-acyl, and 3-carboxyhydrazido coumarin derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:10, 2011
2D MI-DRAGON: a new predictor for protein-ligands interactions and theoretic-experimental studies of US FDA drug-target network, oxoisoaporphine inhibitors for MAO-A and human parasite proteins.European journal of medicinal chemistry, , Volume: 46, Issue:12, 2011
Synthesis of new 3-aryl-4,5-dihydropyrazole-1-carbothioamide derivatives. An investigation on their ability to inhibit monoamine oxidase.European journal of medicinal chemistry, , Volume: 45, Issue:10, 2010
A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors.Bioorganic & medicinal chemistry, , Volume: 18, Issue:3, 2010
Synthesis of new series of quinoxaline based MAO-inhibitors and docking studies.European journal of medicinal chemistry, , Volume: 45, Issue:10, 2010
Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry, , Jul-15, Volume: 18, Issue:14, 2010
Synthesis, stereochemical separation, and biological evaluation of selective inhibitors of human MAO-B: 1-(4-arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazines.Journal of medicinal chemistry, , Sep-09, Volume: 53, Issue:17, 2010
Investigations on the 2-thiazolylhydrazyne scaffold: synthesis and molecular modeling of selective human monoamine oxidase inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010
Synthesis and inhibitory activity against human monoamine oxidase of N1-thiocarbamoyl-3,5-di(hetero)aryl-4,5-dihydro-(1H)-pyrazole derivatives.European journal of medicinal chemistry, , Volume: 45, Issue:2, 2010
Synthesis and molecular modelling studies of prenylated pyrazolines as MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 20, Issue:22, 2010
Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B.Bioorganic & medicinal chemistry letters, , May-01, Volume: 20, Issue:9, 2010
Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins.Journal of medicinal chemistry, , Apr-09, Volume: 52, Issue:7, 2009
Chalcones: a valid scaffold for monoamine oxidases inhibitors.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.Journal of medicinal chemistry, , Nov-13, Volume: 51, Issue:21, 2008
Synthesis, stereochemical identification, and selective inhibitory activity against human monoamine oxidase-B of 2-methylcyclohexylidene-(4-arylthiazol-2-yl)hydrazones.Journal of medicinal chemistry, , Aug-28, Volume: 51, Issue:16, 2008
The evaluation of N-propargylamine-2-aminotetralin as an inhibitor of monoamine oxidase.Bioorganic & medicinal chemistry letters, , 07-01, Volume: 67, 2022
Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models.European journal of medicinal chemistry, , Jul-05, Volume: 237, 2022
Synthesis and biological evaluation of 3-styrylchromone derivatives as selective monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry, , 07-15, Volume: 42, 2021
2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Feb-05, Volume: 211, 2021
[no title available]Journal of medicinal chemistry, , 02-13, Volume: 63, Issue:3, 2020
Rational design, synthesis and biological evaluation of novel multitargeting anti-AD iron chelators with potent MAO-B inhibitory and antioxidant activity.Bioorganic & medicinal chemistry, , 06-15, Volume: 28, Issue:12, 2020
Chromone and donepezil hybrids as new multipotent cholinesterase and monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.RSC medicinal chemistry, , Feb-01, Volume: 11, Issue:2, 2020
Synthesis of natural product-like polyprenylated phenols and quinones: Evaluation of their neuroprotective activities.Bioorganic & medicinal chemistry, , 01-01, Volume: 28, Issue:1, 2020
Discovery, synthesis, biological evaluation and molecular docking study of (R)-5-methylmellein and its analogs as selective monoamine oxidase A inhibitors.Bioorganic & medicinal chemistry, , 05-15, Volume: 27, Issue:10, 2019
Dipropargyl substituted diphenylpyrimidines as dual inhibitors of monoamine oxidase and acetylcholinesterase.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity.Bioorganic & medicinal chemistry letters, , 03-15, Volume: 29, Issue:6, 2019
Design, synthesis and biological evaluation of hydroxypyridinone-coumarin hybrids as multimodal monoamine oxidase B inhibitors and iron chelates against Alzheimer's disease.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
Selected aryl thiosemicarbazones as a new class of multi-targeted monoamine oxidase inhibitors.MedChemComm, , Nov-01, Volume: 9, Issue:11, 2018
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jan-01, Volume: 143, 2018
Selective inhibition of monoamine oxidase A by hispidol.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 28, Issue:4, 2018
Design, synthesis, and evaluation of salicyladimine derivatives as multitarget-directed ligands against Alzheimer's disease.Bioorganic & medicinal chemistry, , 11-01, Volume: 25, Issue:21, 2017
Synthesis and pharmacological evaluation of multi-functional homoisoflavonoid derivatives as potent inhibitors of monoamine oxidase B and cholinesterase for the treatment of Alzheimer's disease.MedChemComm, , Jul-01, Volume: 8, Issue:7, 2017
N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.Bioorganic & medicinal chemistry, , 01-15, Volume: 25, Issue:2, 2017
Design, synthesis and evaluation of coumarin-pargyline hybrids as novel dual inhibitors of monoamine oxidases and amyloid-β aggregation for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Sep-29, Volume: 138, 2017
Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents.Journal of medicinal chemistry, , 07-28, Volume: 59, Issue:14, 2016
Potent selective monoamine oxidase B inhibition by maackiain, a pterocarpan from the roots of Sophora flavescens.Bioorganic & medicinal chemistry letters, , 10-01, Volume: 26, Issue:19, 2016
Multifunctional coumarin derivatives: monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer's disease.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 25, Issue:3, 2015
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.Bioorganic & medicinal chemistry, , Feb-15, Volume: 23, Issue:4, 2015
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.Journal of medicinal chemistry, , Jul-23, Volume: 58, Issue:14, 2015
Synthesis and evaluation of selegiline derivatives as monoamine oxidase inhibitor, antioxidant and metal chelator against Alzheimer's disease.Bioorganic & medicinal chemistry, , Jul-01, Volume: 23, Issue:13, 2015
Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.Bioorganic & medicinal chemistry, , Dec-01, Volume: 21, Issue:23, 2013
Nonpeptidic propargylamines as inhibitors of lysine specific demethylase 1 (LSD1) with cellular activity.Journal of medicinal chemistry, , Sep-26, Volume: 56, Issue:18, 2013
A novel series of tacrine-selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Volume: 62, 2013
Knowledge based identification of MAO-B selective inhibitors using pharmacophore and structure based virtual screening models.European journal of medicinal chemistry, , Volume: 44, Issue:9, 2009
Docking studies on monoamine oxidase-B inhibitors: estimation of inhibition constants (K(i)) of a series of experimentally tested compounds.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 15, Issue:20, 2005
Design, synthesis, in-vitro, in-vivo and ex-vivo pharmacology of thiazolidine-2,4-dione derivatives as selective and reversible monoamine oxidase-B inhibitors.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 76, 2022
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.Bioorganic & medicinal chemistry, , Feb-15, Volume: 23, Issue:4, 2015
Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs.ACS medicinal chemistry letters, , Oct-15, Volume: 3, Issue:1, 2011
Identification of novel monoamine oxidase B inhibitors by structure-based virtual screening.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 20, Issue:17, 2010
Fluorinated phenylcyclopropylamines. 2. Effects of aromatic ring substitution and of absolute configuration on inhibition of microbial tyramine oxidase.Journal of medicinal chemistry, , Nov-18, Volume: 47, Issue:24, 2004
Fluorinated phenylcyclopropylamines. 1. Synthesis and effect of fluorine substitution at the cyclopropane ring on inhibition of microbial tyramine oxidase.Journal of medicinal chemistry, , Mar-25, Volume: 47, Issue:7, 2004
Design, synthesis, in-vitro, in-vivo and ex-vivo pharmacology of thiazolidine-2,4-dione derivatives as selective and reversible monoamine oxidase-B inhibitors.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 76, 2022
Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs.ACS medicinal chemistry letters, , Oct-15, Volume: 3, Issue:1, 2011
Identification of novel monoamine oxidase B inhibitors by structure-based virtual screening.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 20, Issue:17, 2010
Phenothiazine, anthraquinone and related tricyclic derivatives as inhibitors of monoamine oxidase.Bioorganic & medicinal chemistry, , 01-15, Volume: 54, 2022
Discovery of monoamine oxidase inhibitors by medicinal chemistry approaches.MedChemComm, , Jan-01, Volume: 10, Issue:1, 2019
Selective inhibition of monoamine oxidase A by purpurin, an anthraquinone.Bioorganic & medicinal chemistry letters, , 03-01, Volume: 27, Issue:5, 2017
Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
Isatoic anhydrides as novel inhibitors of monoamine oxidase.Bioorganic & medicinal chemistry, , 11-01, Volume: 73, 2022
The inhibition of monoamine oxidase by 2H-1,4-benzothiazin-3(4H)-ones.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 77, 2022
Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure.Bioorganic & medicinal chemistry letters, , 04-15, Volume: 29, Issue:8, 2019
(E)-3-Heteroarylidenechroman-4-ones as potent and selective monoamine oxidase-B inhibitors.European journal of medicinal chemistry, , Jul-19, Volume: 117, 2016
Identification of the stereochemical requirements in the 4-aryl-2-cycloalkylidenhydrazinylthiazole scaffold for the design of selective human monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry, , May-15, Volume: 22, Issue:10, 2014
Novel polyamine analogues: from substrates towards potential inhibitors of monoamine oxidases.European journal of medicinal chemistry, , Volume: 70, 2013
1,5-Diphenylpenta-2,4-dien-1-ones as potent and selective monoamine oxidase-B inhibitors.European journal of medicinal chemistry, , Volume: 59, 2013
Recent advances in the development of selective human MAO-B inhibitors: (hetero)arylidene-(4-substituted-thiazol-2-yl)hydrazines.European journal of medicinal chemistry, , Volume: 58, 2012
Synthesis and selective human monoamine oxidase inhibition of 3-carbonyl, 3-acyl, and 3-carboxyhydrazido coumarin derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:10, 2011
Inhibition of monoamine oxidase by C5-substituted phthalimide analogues.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.Journal of medicinal chemistry, , Aug-11, Volume: 54, Issue:15, 2011
Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues.Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry, , Jul-15, Volume: 18, Issue:14, 2010
Synthesis, stereochemical separation, and biological evaluation of selective inhibitors of human MAO-B: 1-(4-arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazines.Journal of medicinal chemistry, , Sep-09, Volume: 53, Issue:17, 2010
Investigations on the 2-thiazolylhydrazyne scaffold: synthesis and molecular modeling of selective human monoamine oxidase inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010
Synthesis and inhibitory activity against human monoamine oxidase of N1-thiocarbamoyl-3,5-di(hetero)aryl-4,5-dihydro-(1H)-pyrazole derivatives.European journal of medicinal chemistry, , Volume: 45, Issue:2, 2010
Synthesis and molecular modelling studies of prenylated pyrazolines as MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 20, Issue:22, 2010
Inhibition of monoamine oxidase by (E)-styrylisatin analogues.Bioorganic & medicinal chemistry letters, , May-01, Volume: 19, Issue:9, 2009
Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors.The Journal of biological chemistry, , Apr-22, Volume: 280, Issue:16, 2005
Docking studies on monoamine oxidase-B inhibitors: estimation of inhibition constants (K(i)) of a series of experimentally tested compounds.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 15, Issue:20, 2005
Tranylcypromine Based Lysine-Specific Demethylase 1 Inhibitor: Summary and Perspective.Journal of medicinal chemistry, , 12-10, Volume: 63, Issue:23, 2020
Dual inhibitors of LSD1 and spermine oxidase.MedChemComm, , May-01, Volume: 10, Issue:5, 2019
Tranylcypromine and 6-trifluoroethyl thienopyrimidine hybrid as LSD1 inhibitor.Bioorganic & medicinal chemistry letters, , 03-15, Volume: 29, Issue:6, 2019
Identification of selective and reversible LSD1 inhibitors with anti-metastasis activity by high-throughput docking.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 29, Issue:4, 2019
Design, synthesis and evaluation of γ-turn mimetics as LSD1-selective inhibitors.Bioorganic & medicinal chemistry, , 02-01, Volume: 26, Issue:3, 2018
Cyclic peptide inhibitors of lysine-specific demethylase 1 with improved potency identified by alanine scanning mutagenesis.European journal of medicinal chemistry, , Mar-25, Volume: 148, 2018
Histone H3 peptides incorporating modified lysine residues as lysine-specific demethylase 1 inhibitors.Bioorganic & medicinal chemistry letters, , 01-15, Volume: 28, Issue:2, 2018
Identification of SNAIL1 Peptide-Based Irreversible Lysine-Specific Demethylase 1-Selective Inactivators.Journal of medicinal chemistry, , Feb-25, Volume: 59, Issue:4, 2016
Lysine demethylases inhibitors.Journal of medicinal chemistry, , Dec-22, Volume: 54, Issue:24, 2011
Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases A and B by 2-aryl-2-fluoro-cyclopropylamines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B.Bioorganic & medicinal chemistry letters, , May-15, Volume: 18, Issue:10, 2008
Drug discovery of histone lysine demethylases (KDMs) inhibitors (progress from 2018 to present).European journal of medicinal chemistry, , Mar-05, Volume: 231, 2022
[no title available]Journal of medicinal chemistry, , 03-10, Volume: 65, Issue:5, 2022
Identification of Novel Selective Lysine-Specific Demethylase 1 (LSD1) Inhibitors Using a Pharmacophore-Based Virtual Screening Combined with Docking.Chemical biology & drug design, , Volume: 85, Issue:6, 2015
The evaluation of N-propargylamine-2-aminotetralin as an inhibitor of monoamine oxidase.Bioorganic & medicinal chemistry letters, , 07-01, Volume: 67, 2022
Synthesis and human monoamine oxidase inhibitory activity of novel C2-, C3- and C4-substituted phthalonitriles.Bioorganic & medicinal chemistry letters, , 10-15, Volume: 74, 2022
Synthesis of novel thiazolyl hydrazone derivatives as potent dual monoamine oxidase-aromatase inhibitors.European journal of medicinal chemistry, , Feb-05, Volume: 229, 2022
New 2-Pyrazoline and Hydrazone Derivatives as Potent and Selective Monoamine Oxidase A Inhibitors.Journal of medicinal chemistry, , 02-25, Volume: 64, Issue:4, 2021
Halting colorectal cancer metastasis via novel dual nanomolar MMP-9/MAO-A quinoxaline-based inhibitors; design, synthesis, and evaluation.European journal of medicinal chemistry, , Oct-15, Volume: 222, 2021
Discovery of new tranylcypromine derivatives as highly potent LSD1 inhibitors.Bioorganic & medicinal chemistry letters, , 06-01, Volume: 41, 2021
Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies.European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
Computational Fragment-Based Design Facilitates Discovery of Potent and Selective Monoamine Oxidase-B (MAO-B) Inhibitor.Journal of medicinal chemistry, , 12-10, Volume: 63, Issue:23, 2020
[no title available]Journal of medicinal chemistry, , 02-13, Volume: 63, Issue:3, 2020
Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure.Bioorganic & medicinal chemistry letters, , 04-15, Volume: 29, Issue:8, 2019
Design, synthesis and evaluation of pentacycloundecane and hexacycloundecane propargylamine derivatives as multifunctional neuroprotective agents.European journal of medicinal chemistry, , Feb-01, Volume: 163, 2019
(Pyrrolo-pyridin-5-yl)benzamides: BBB permeable monoamine oxidase B inhibitors with neuroprotective effect on cortical neurons.European journal of medicinal chemistry, , Jan-15, Volume: 162, 2019
Carboxamides vs. methanimines: Crystal structures, binding interactions, photophysical studies, and biological evaluation of (indazole-5-yl)methanimines as monoamine oxidase B and acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Oct-01, Volume: 179, 2019
Discovery of novel 2,3-dihydro-1H-inden-1-amine derivatives as selective monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry letters, , 05-01, Volume: 29, Issue:9, 2019
1,3,4-Oxadiazol-2-ylbenzenesulfonamides as privileged structures for the inhibition of monoamine oxidase B.Bioorganic & medicinal chemistry letters, , 11-01, Volume: 29, Issue:21, 2019
4-tert-Pentylphenoxyalkyl derivatives - Histamine HBioorganic & medicinal chemistry letters, , 12-15, Volume: 28, Issue:23-24, 2018
Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.European journal of medicinal chemistry, , Oct-05, Volume: 158, 2018
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.European journal of medicinal chemistry, , Aug-05, Volume: 156, 2018
[no title available]MedChemComm, , Jul-01, Volume: 9, Issue:7, 2018
Development of Novel Monoamine Oxidase-B (MAO-B) Inhibitors with Reduced Blood-Brain Barrier Permeability for the Potential Management of Noncentral Nervous System (CNS) Diseases.Journal of medicinal chemistry, , 08-23, Volume: 61, Issue:16, 2018
Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B inhibitors toward Parkinson's disease therapy.Bioorganic & medicinal chemistry, , 01-01, Volume: 26, Issue:1, 2018
Design, synthesis and in vitro evaluation of stilbene derivatives as novel LSD1 inhibitors for AML therapy.Bioorganic & medicinal chemistry, , 12-15, Volume: 26, Issue:23-24, 2018
Synthesis and evaluation of 2-substituted 4(3H)-quinazolinone thioether derivatives as monoamine oxidase inhibitors.Bioorganic & medicinal chemistry, , 11-01, Volume: 26, Issue:20, 2018
Developing hybrid molecule therapeutics for diverse enzyme inhibitory action: Active role of coumarin-based structural leads in drug discovery.Bioorganic & medicinal chemistry, , 07-30, Volume: 26, Issue:13, 2018
Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents.European journal of medicinal chemistry, , Jan-01, Volume: 143, 2018
Design, synthesis and biological assessment of new thiazolylhydrazine derivatives as selective and reversible hMAO-A inhibitors.European journal of medicinal chemistry, , Jan-20, Volume: 144, 2018
[no title available]MedChemComm, , Feb-01, Volume: 9, Issue:2, 2018
[no title available]European journal of medicinal chemistry, , Mar-25, Volume: 148, 2018
The evaluation of 1,4-benzoquinones as inhibitors of human monoamine oxidase.European journal of medicinal chemistry, , Jul-28, Volume: 135, 2017
Design and synthesis of tranylcypromine derivatives as novel LSD1/HDACs dual inhibitors for cancer treatment.European journal of medicinal chemistry, , Nov-10, Volume: 140, 2017
Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jan-05, Volume: 125, 2017
MAO inhibitory activity of bromo-2-phenylbenzofurans: synthesis, MedChemComm, , Sep-01, Volume: 8, Issue:9, 2017
Coumarin versus Chromone Monoamine Oxidase B Inhibitors: Quo Vadis?Journal of medicinal chemistry, , 08-24, Volume: 60, Issue:16, 2017
MAO enzymes inhibitory activity of new benzimidazole derivatives including hydrazone and propargyl side chains.European journal of medicinal chemistry, , May-05, Volume: 131, 2017
Discovery of highly selective and potent monoamine oxidase B inhibitors: Contribution of additional phenyl rings introduced into 2-aryl-1,3,4-oxadiazin-5(6H)-one.European journal of medicinal chemistry, , Apr-21, Volume: 130, 2017
Anisucoumaramide, a Bioactive Coumarin from Clausena anisum-olens.Journal of natural products, , 04-28, Volume: 80, Issue:4, 2017
Synthesis and structure-activity relationship study of novel 3-heteroarylcoumarins based on pyridazine scaffold as selective MAO-B inhibitors.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
Monoamine Oxidase Inhibitory Activity of Novel Pyrazoline Analogues: Curcumin Based Design and Synthesis.ACS medicinal chemistry letters, , Jan-14, Volume: 7, Issue:1, 2016
Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation.European journal of medicinal chemistry, , Oct-04, Volume: 121, 2016
Novel tricyclic pyrazolo[1,5-d][1,4]benzoxazepin-5(6H)-one: Design, synthesis, model and use as hMAO-B inhibitors.Bioorganic & medicinal chemistry, , Apr-15, Volume: 24, Issue:8, 2016
New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties.European journal of medicinal chemistry, , Oct-04, Volume: 121, 2016
(E)-3-Heteroarylidenechroman-4-ones as potent and selective monoamine oxidase-B inhibitors.European journal of medicinal chemistry, , Jul-19, Volume: 117, 2016
Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry, , 10-15, Volume: 24, Issue:20, 2016
Development of fluorinated methoxylated chalcones as selective monoamine oxidase-B inhibitors: Synthesis, biochemistry and molecular docking studies.Bioorganic chemistry, , Volume: 62, 2015
Design and synthesis of novel 2-pyrazoline-1-ethanone derivatives as selective MAO inhibitors.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
Potent and selective MAO-B inhibitory activity: amino- versus nitro-3-arylcoumarin derivatives.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 25, Issue:3, 2015
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.Bioorganic & medicinal chemistry, , Feb-15, Volume: 23, Issue:4, 2015
Novel 2H-chromen-2-one derivatives of resveratrol: Design, synthesis, modeling and use as human monoamine oxidase inhibitors.European journal of medicinal chemistry, , Oct-20, Volume: 103, 2015
Synthesis of a series of unsaturated ketone derivatives as selective and reversible monoamine oxidase inhibitors.Bioorganic & medicinal chemistry, , Oct-01, Volume: 23, Issue:19, 2015
Evaluation of Homobivalent Carbolines as Designed Multiple Ligands for the Treatment of Neurodegenerative Disorders.Journal of medicinal chemistry, , Aug-27, Volume: 58, Issue:16, 2015
Synthesis and evaluation of selegiline derivatives as monoamine oxidase inhibitor, antioxidant and metal chelator against Alzheimer's disease.Bioorganic & medicinal chemistry, , Jul-01, Volume: 23, Issue:13, 2015
Monoamine oxidase inhibitory activity of 2-aryl-4H-chromen-4-ones.Bioorganic chemistry, , Volume: 58, 2015
N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.Journal of medicinal chemistry, , Dec-26, Volume: 57, Issue:24, 2014
Identification of the stereochemical requirements in the 4-aryl-2-cycloalkylidenhydrazinylthiazole scaffold for the design of selective human monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry, , May-15, Volume: 22, Issue:10, 2014
Novel polyamine analogues: from substrates towards potential inhibitors of monoamine oxidases.European journal of medicinal chemistry, , Volume: 70, 2013
1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases.Bioorganic & medicinal chemistry, , Dec-01, Volume: 21, Issue:23, 2013
Chromenylchalcones with inhibitory effects on monoamine oxidase B.Bioorganic & medicinal chemistry, , Dec-15, Volume: 21, Issue:24, 2013
Development of a novel fluorine-18 labeled deuterated fluororasagiline ([(18)F]fluororasagiline-D2) radioligand for PET studies of monoamino oxidase B (MAO-B).Bioorganic & medicinal chemistry, , Nov-01, Volume: 21, Issue:21, 2013
Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones.Journal of medicinal chemistry, , Jun-13, Volume: 56, Issue:11, 2013
Synthesis and biological evaluation of novel propargyl amines as potential fluorine-18 labeled radioligands for detection of MAO-B activity.Bioorganic & medicinal chemistry, , Jan-01, Volume: 21, Issue:1, 2013
1,5-Diphenylpenta-2,4-dien-1-ones as potent and selective monoamine oxidase-B inhibitors.European journal of medicinal chemistry, , Volume: 59, 2013
Oxazolopyridines and thiazolopyridines as monoamine oxidase B inhibitors for the treatment of Parkinson's disease.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Synthesis of (E)-8-(3-chlorostyryl)caffeine analogues leading to 9-deazaxanthine derivatives as dual A(2A) antagonists/MAO-B inhibitors.Journal of medicinal chemistry, , Feb-14, Volume: 56, Issue:3, 2013
Monoamine oxidase inhibitory activity of 3,5-biaryl-4,5-dihydro-1H-pyrazole-1-carboxylate derivatives.European journal of medicinal chemistry, , Volume: 69, 2013
Design, synthesis, and in vitro hMAO-B inhibitory evaluation of some 1-methyl-3,5-diphenyl-4,5-dihydro-1H-pyrazoles.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 23, Issue:18, 2013
Novel (coumarin-3-yl)carbamates as selective MAO-B inhibitors: synthesis, in vitro and in vivo assays, theoretical evaluation of ADME properties and docking study.European journal of medicinal chemistry, , Volume: 63, 2013
Inhibition of monoamine oxidase by phthalide analogues.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 23, Issue:5, 2013
Inhibition of monoamine oxidase by 3,4-dihydro-2(1H)-quinolinone derivatives.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 23, Issue:20, 2013
Sulfanylphthalonitrile analogues as selective and potent inhibitors of monoamine oxidase B.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 22, Issue:24, 2012
Multitarget-directed benzylideneindanone derivatives: anti-β-amyloid (Aβ) aggregation, antioxidant, metal chelation, and monoamine oxidase B (MAO-B) inhibition properties against Alzheimer's disease.Journal of medicinal chemistry, , Oct-11, Volume: 55, Issue:19, 2012
Synthesis and biological assessment of novel 2-thiazolylhydrazones and computational analysis of their recognition by monoamine oxidase B.European journal of medicinal chemistry, , Volume: 48, 2012
Recent advances in the development of selective human MAO-B inhibitors: (hetero)arylidene-(4-substituted-thiazol-2-yl)hydrazines.European journal of medicinal chemistry, , Volume: 58, 2012
Synthesis and evaluation of aplysinopsin analogs as inhibitors of human monoamine oxidase A and B.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 22, Issue:15, 2012
Synthesis and evaluation of [¹⁸F]fluororasagiline, a novel positron emission tomography (PET) radioligand for monoamine oxidase B (MAO-B).Bioorganic & medicinal chemistry, , May-01, Volume: 20, Issue:9, 2012
Hydroxycoumarins as selective MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 22, Issue:1, 2012
Homoisoflavonoids: natural scaffolds with potent and selective monoamine oxidase-B inhibition properties.Journal of medicinal chemistry, , Apr-14, Volume: 54, Issue:7, 2011
Synthesis and selective human monoamine oxidase inhibition of 3-carbonyl, 3-acyl, and 3-carboxyhydrazido coumarin derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:10, 2011
MAO inhibitory activity modulation: 3-Phenylcoumarins versus 3-benzoylcoumarins.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 21, Issue:14, 2011
2D MI-DRAGON: a new predictor for protein-ligands interactions and theoretic-experimental studies of US FDA drug-target network, oxoisoaporphine inhibitors for MAO-A and human parasite proteins.European journal of medicinal chemistry, , Volume: 46, Issue:12, 2011
Pyrazoline based MAO inhibitors: synthesis, biological evaluation and SAR studies.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 21, Issue:14, 2011
Synthesis of three novel fluorine-18 labeled analogues of L-deprenyl for positron emission tomography (PET) studies of monoamine oxidase B (MAO-B).Journal of medicinal chemistry, , Oct-27, Volume: 54, Issue:20, 2011
Chromone 3-phenylcarboxamides as potent and selective MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Synthesis, human monoamine oxidase inhibitory activity and molecular docking studies of 3-heteroarylcoumarin derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:4, 2011
Development of selective and reversible pyrazoline based MAO-B inhibitors: virtual screening, synthesis and biological evaluation.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 21, Issue:7, 2011
Synthesis and study of a series of 3-arylcoumarins as potent and selective monoamine oxidase B inhibitors.Journal of medicinal chemistry, , Oct-27, Volume: 54, Issue:20, 2011
Chromone, a privileged scaffold for the development of monoamine oxidase inhibitors.Journal of medicinal chemistry, , Jul-28, Volume: 54, Issue:14, 2011
Synthesis of new 3-aryl-4,5-dihydropyrazole-1-carbothioamide derivatives. An investigation on their ability to inhibit monoamine oxidase.European journal of medicinal chemistry, , Volume: 45, Issue:10, 2010
A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors.Bioorganic & medicinal chemistry, , Volume: 18, Issue:3, 2010
Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry, , Jul-15, Volume: 18, Issue:14, 2010
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: deBioorganic & medicinal chemistry, , Nov-01, Volume: 18, Issue:21, 2010
Synthesis, stereochemical separation, and biological evaluation of selective inhibitors of human MAO-B: 1-(4-arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazines.Journal of medicinal chemistry, , Sep-09, Volume: 53, Issue:17, 2010
Investigations on the 2-thiazolylhydrazyne scaffold: synthesis and molecular modeling of selective human monoamine oxidase inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010
Synthesis and inhibitory activity against human monoamine oxidase of N1-thiocarbamoyl-3,5-di(hetero)aryl-4,5-dihydro-(1H)-pyrazole derivatives.European journal of medicinal chemistry, , Volume: 45, Issue:2, 2010
Synthesis and molecular modelling studies of prenylated pyrazolines as MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 20, Issue:22, 2010
New halogenated 3-phenylcoumarins as potent and selective MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 20, Issue:17, 2010
Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B.Bioorganic & medicinal chemistry letters, , May-01, Volume: 20, Issue:9, 2010
A new series of 3-phenylcoumarins as potent and selective MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 19, Issue:12, 2009
Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins.Journal of medicinal chemistry, , Apr-09, Volume: 52, Issue:7, 2009
Chalcones: a valid scaffold for monoamine oxidases inhibitors.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.Journal of medicinal chemistry, , Nov-13, Volume: 51, Issue:21, 2008
Multi-target-directed ligands to combat neurodegenerative diseases.Journal of medicinal chemistry, , Feb-14, Volume: 51, Issue:3, 2008
Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.Journal of medicinal chemistry, , Jul-24, Volume: 51, Issue:14, 2008
Synthesis, stereochemical identification, and selective inhibitory activity against human monoamine oxidase-B of 2-methylcyclohexylidene-(4-arylthiazol-2-yl)hydrazones.Journal of medicinal chemistry, , Aug-28, Volume: 51, Issue:16, 2008
Docking studies on monoamine oxidase-B inhibitors: estimation of inhibition constants (K(i)) of a series of experimentally tested compounds.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 15, Issue:20, 2005
Design, synthesis, and biological activities of pyrrolylethanoneamine derivatives, a novel class of monoamine oxidases inhibitors.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Selected aryl thiosemicarbazones as a new class of multi-targeted monoamine oxidase inhibitors.MedChemComm, , Nov-01, Volume: 9, Issue:11, 2018
Design, synthesis, and biological activities of pyrrolylethanoneamine derivatives, a novel class of monoamine oxidases inhibitors.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Fentanyl derivatives bearing aliphatic alkaneguanidinium moieties: a new series of hybrid molecules with significant binding affinity for mu-opioid receptors and I2-imidazoline binding sites.Bioorganic & medicinal chemistry letters, , Jan-19, Volume: 14, Issue:2, 2004
Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.Journal of medicinal chemistry, , Sep-15, Volume: 38, Issue:19, 1995
Potent selective monoamine oxidase B inhibition by maackiain, a pterocarpan from the roots of Sophora flavescens.Bioorganic & medicinal chemistry letters, , 10-01, Volume: 26, Issue:19, 2016
Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO.Bioorganic & medicinal chemistry, , Dec-15, Volume: 19, Issue:24, 2011
The Repertoire of Small-Molecule PET Probes for Neuroinflammation Imaging: Challenges and Opportunities beyond TSPO.Journal of medicinal chemistry, , 12-23, Volume: 64, Issue:24, 2021
New 2-Pyrazoline and Hydrazone Derivatives as Potent and Selective Monoamine Oxidase A Inhibitors.Journal of medicinal chemistry, , 02-25, Volume: 64, Issue:4, 2021
Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity.Bioorganic & medicinal chemistry letters, , 03-15, Volume: 29, Issue:6, 2019
Novel monoamine oxidase inhibitors based on the privileged 2-imidazoline molecular framework.Bioorganic & medicinal chemistry letters, , 01-01, Volume: 29, Issue:1, 2019
1,3,4-Oxadiazol-2-ylbenzenesulfonamides as privileged structures for the inhibition of monoamine oxidase B.Bioorganic & medicinal chemistry letters, , 11-01, Volume: 29, Issue:21, 2019
Selected aryl thiosemicarbazones as a new class of multi-targeted monoamine oxidase inhibitors.MedChemComm, , Nov-01, Volume: 9, Issue:11, 2018
Selective inhibition of monoamine oxidase A by chelerythrine, an isoquinoline alkaloid.Bioorganic & medicinal chemistry letters, , 08-01, Volume: 28, Issue:14, 2018
[no title available]MedChemComm, , Jul-01, Volume: 9, Issue:7, 2018
Synthesis and evaluation of 2-substituted 4(3H)-quinazolinone thioether derivatives as monoamine oxidase inhibitors.Bioorganic & medicinal chemistry, , 11-01, Volume: 26, Issue:20, 2018
Selective inhibition of monoamine oxidase A by hispidol.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 28, Issue:4, 2018
Selective inhibition of monoamine oxidase A by purpurin, an anthraquinone.Bioorganic & medicinal chemistry letters, , 03-01, Volume: 27, Issue:5, 2017
The evaluation of 1,4-benzoquinones as inhibitors of human monoamine oxidase.European journal of medicinal chemistry, , Jul-28, Volume: 135, 2017
An evaluation of synthetic indole derivatives as inhibitors of monoamine oxidase.Bioorganic & medicinal chemistry letters, , May-01, Volume: 26, Issue:9, 2016
Inhibition of monoamine oxidase by benzoxathiolone analogues.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 26, Issue:4, 2016
The synthesis and evaluation of sesamol and benzodioxane derivatives as inhibitors of monoamine oxidase.Bioorganic & medicinal chemistry letters, , May-01, Volume: 25, Issue:9, 2015
Inhibition of monoamine oxidase by indole-5,6-dicarbonitrile derivatives.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 25, Issue:6, 2015
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.Bioorganic & medicinal chemistry, , Feb-15, Volume: 23, Issue:4, 2015
Monoamine oxidase inhibitory activities of heterocyclic chalcones.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 25, Issue:22, 2015
α-Tetralone derivatives as inhibitors of monoamine oxidase.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 24, Issue:12, 2014
New insights into the biological properties of Crocus sativus L.: chemical modifications, human monoamine oxidases inhibition and molecular modeling studies.European journal of medicinal chemistry, , Jul-23, Volume: 82, 2014
Inhibition of monoamine oxidase by 3,4-dihydro-2(1H)-quinolinone derivatives.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 23, Issue:20, 2013
Inhibition of monoamine oxidase by phthalide analogues.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 23, Issue:5, 2013
Inhibition of monoamine oxidase by 8-[(phenylethyl)sulfanyl]caffeine analogues.Bioorganic & medicinal chemistry, , Dec-15, Volume: 20, Issue:24, 2012
Docking studies on monoamine oxidase-B inhibitors: estimation of inhibition constants (K(i)) of a series of experimentally tested compounds.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 15, Issue:20, 2005
Design, synthesis, in-vitro, in-vivo and ex-vivo pharmacology of thiazolidine-2,4-dione derivatives as selective and reversible monoamine oxidase-B inhibitors.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 76, 2022
Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs.ACS medicinal chemistry letters, , Oct-15, Volume: 3, Issue:1, 2011
Identification of novel monoamine oxidase B inhibitors by structure-based virtual screening.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 20, Issue:17, 2010
Design, synthesis, in-vitro, in-vivo and ex-vivo pharmacology of thiazolidine-2,4-dione derivatives as selective and reversible monoamine oxidase-B inhibitors.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 76, 2022
[no title available]RSC medicinal chemistry, , Jul-20, Volume: 13, Issue:7, 2022
Overcoming undesirable hERG affinity by incorporating fluorine atoms: A case of MAO-B inhibitors derived from 1 H-pyrrolo-[3,2-c]quinolines.European journal of medicinal chemistry, , Jun-05, Volume: 236, 2022
[no title available]Journal of medicinal chemistry, , 03-10, Volume: 65, Issue:5, 2022
[no title available]European journal of medicinal chemistry, , Jan-15, Volume: 228, 2022
4-Oxoquinolines and monoamine oxidase: When tautomerism matters.European journal of medicinal chemistry, , Mar-05, Volume: 213, 2021
Synthesis and biological evaluation of 3-styrylchromone derivatives as selective monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry, , 07-15, Volume: 42, 2021
Novel 1-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-indene-4-thiol derivatives as potent selective human monoamine oxidase B inhibitors: Design, SAR development, and biological evaluation.Bioorganic & medicinal chemistry letters, , 07-01, Volume: 43, 2021
Mapping Chromone-3-Phenylcarboxamide Pharmacophore: Journal of medicinal chemistry, , 08-12, Volume: 64, Issue:15, 2021
Pyrimido[1,2-b]indazole derivatives: Selective inhibitors of human monoamine oxidase B with neuroprotective activity.European journal of medicinal chemistry, , Jan-01, Volume: 209, 2021
Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies.European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
[no title available]European journal of medicinal chemistry, , Dec-15, Volume: 208, 2020
[no title available]European journal of medicinal chemistry, , Dec-01, Volume: 207, 2020
Computational Fragment-Based Design Facilitates Discovery of Potent and Selective Monoamine Oxidase-B (MAO-B) Inhibitor.Journal of medicinal chemistry, , 12-10, Volume: 63, Issue:23, 2020
Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure.Bioorganic & medicinal chemistry letters, , 04-15, Volume: 29, Issue:8, 2019
Carboxamides vs. methanimines: Crystal structures, binding interactions, photophysical studies, and biological evaluation of (indazole-5-yl)methanimines as monoamine oxidase B and acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Oct-01, Volume: 179, 2019
Novel monoamine oxidase inhibitors based on the privileged 2-imidazoline molecular framework.Bioorganic & medicinal chemistry letters, , 01-01, Volume: 29, Issue:1, 2019
(Pyrrolo-pyridin-5-yl)benzamides: BBB permeable monoamine oxidase B inhibitors with neuroprotective effect on cortical neurons.European journal of medicinal chemistry, , Jan-15, Volume: 162, 2019
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors.European journal of medicinal chemistry, , Jan-01, Volume: 161, 2019
Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.European journal of medicinal chemistry, , Oct-05, Volume: 158, 2018
Development of Novel Monoamine Oxidase-B (MAO-B) Inhibitors with Reduced Blood-Brain Barrier Permeability for the Potential Management of Noncentral Nervous System (CNS) Diseases.Journal of medicinal chemistry, , 08-23, Volume: 61, Issue:16, 2018
Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B inhibitors toward Parkinson's disease therapy.Bioorganic & medicinal chemistry, , 01-01, Volume: 26, Issue:1, 2018
4-tert-Pentylphenoxyalkyl derivatives - Histamine HBioorganic & medicinal chemistry letters, , 12-15, Volume: 28, Issue:23-24, 2018
[no title available]European journal of medicinal chemistry, , Mar-25, Volume: 148, 2018
The evaluation of 1,4-benzoquinones as inhibitors of human monoamine oxidase.European journal of medicinal chemistry, , Jul-28, Volume: 135, 2017
Coumarin versus Chromone Monoamine Oxidase B Inhibitors: Quo Vadis?Journal of medicinal chemistry, , 08-24, Volume: 60, Issue:16, 2017
Discovery of highly selective and potent monoamine oxidase B inhibitors: Contribution of additional phenyl rings introduced into 2-aryl-1,3,4-oxadiazin-5(6H)-one.European journal of medicinal chemistry, , Apr-21, Volume: 130, 2017
An evaluation of synthetic indole derivatives as inhibitors of monoamine oxidase.Bioorganic & medicinal chemistry letters, , May-01, Volume: 26, Issue:9, 2016
Inhibition of monoamine oxidase by benzoxathiolone analogues.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 26, Issue:4, 2016
Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors.Journal of medicinal chemistry, , 06-23, Volume: 59, Issue:12, 2016
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.Bioorganic & medicinal chemistry, , Feb-15, Volume: 23, Issue:4, 2015
Synthesis of a series of unsaturated ketone derivatives as selective and reversible monoamine oxidase inhibitors.Bioorganic & medicinal chemistry, , Oct-01, Volume: 23, Issue:19, 2015
Indazole- and indole-5-carboxamides: selective and reversible monoamine oxidase B inhibitors with subnanomolar potency.Journal of medicinal chemistry, , Aug-14, Volume: 57, Issue:15, 2014
1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases.Bioorganic & medicinal chemistry, , Dec-01, Volume: 21, Issue:23, 2013
Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones.Journal of medicinal chemistry, , Jun-13, Volume: 56, Issue:11, 2013
Knowledge based identification of MAO-B selective inhibitors using pharmacophore and structure based virtual screening models.European journal of medicinal chemistry, , Volume: 44, Issue:9, 2009
Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs.Journal of medicinal chemistry, , Nov-15, Volume: 50, Issue:23, 2007
Chromone 3-phenylcarboxamides as potent and selective MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B.Bioorganic & medicinal chemistry letters, , May-01, Volume: 20, Issue:9, 2010
Acetylene Group, Friend or Foe in Medicinal Chemistry.Journal of medicinal chemistry, , 06-11, Volume: 63, Issue:11, 2020
[no title available]MedChemComm, , Feb-01, Volume: 9, Issue:2, 2018
Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.Bioorganic & medicinal chemistry, , Dec-01, Volume: 21, Issue:23, 2013
Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease.Journal of medicinal chemistry, , Jul-25, Volume: 56, Issue:14, 2013
Multitarget-directed benzylideneindanone derivatives: anti-β-amyloid (Aβ) aggregation, antioxidant, metal chelation, and monoamine oxidase B (MAO-B) inhibition properties against Alzheimer's disease.Journal of medicinal chemistry, , Oct-11, Volume: 55, Issue:19, 2012
Multi-target-directed ligands to combat neurodegenerative diseases.Journal of medicinal chemistry, , Feb-14, Volume: 51, Issue:3, 2008
Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues.Journal of medicinal chemistry, , Mar-25, Volume: 47, Issue:7, 2004
Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy.European journal of medicinal chemistry, , Apr-05, Volume: 233, 2022
Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades.Journal of medicinal chemistry, , 03-24, Volume: 65, Issue:6, 2022
Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease.European journal of medicinal chemistry, , Feb-01, Volume: 163, 2019
Promising Non-cytotoxic Monosubstituted Chalcones to Target Monoamine Oxidase-B.ACS medicinal chemistry letters, , Jul-08, Volume: 12, Issue:7, 2021
Chromenylchalcones with inhibitory effects on monoamine oxidase B.Bioorganic & medicinal chemistry, , Dec-15, Volume: 21, Issue:24, 2013
Chalcones: a valid scaffold for monoamine oxidases inhibitors.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies.European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
Inhibition of monoamine oxidase by derivatives of piperine, an alkaloid from the pepper plant Piper nigrum, for possible use in Parkinson's disease.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 22, Issue:23, 2012
New Frontiers in Selective Human MAO-B Inhibitors.Journal of medicinal chemistry, , Sep-10, Volume: 58, Issue:17, 2015
Docking studies on monoamine oxidase-B inhibitors: estimation of inhibition constants (K(i)) of a series of experimentally tested compounds.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 15, Issue:20, 2005
Promising Non-cytotoxic Monosubstituted Chalcones to Target Monoamine Oxidase-B.ACS medicinal chemistry letters, , Jul-08, Volume: 12, Issue:7, 2021
Synthesis of a series of unsaturated ketone derivatives as selective and reversible monoamine oxidase inhibitors.Bioorganic & medicinal chemistry, , Oct-01, Volume: 23, Issue:19, 2015
Isatoic anhydrides as novel inhibitors of monoamine oxidase.Bioorganic & medicinal chemistry, , 11-01, Volume: 73, 2022
The inhibition of monoamine oxidase by 2H-1,4-benzothiazin-3(4H)-ones.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 77, 2022
Evaluation of nitrocatechol chalcone and pyrazoline derivatives as inhibitors of catechol-O-methyltransferase and monoamine oxidase.Bioorganic & medicinal chemistry letters, , 06-15, Volume: 30, Issue:12, 2020
Monoamine Oxidase Inhibitory Activity of Novel Pyrazoline Analogues: Curcumin Based Design and Synthesis.ACS medicinal chemistry letters, , Jan-14, Volume: 7, Issue:1, 2016
Design, synthesis, in-vitro, in-vivo and ex-vivo pharmacology of thiazolidine-2,4-dione derivatives as selective and reversible monoamine oxidase-B inhibitors.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 76, 2022
Structure-activity relationship and docking studies of thiazolidinedione-type compounds with monoamine oxidase B.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 21, Issue:16, 2011
Identification of novel monoamine oxidase B inhibitors by structure-based virtual screening.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 20, Issue:17, 2010
Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities.Journal of medicinal chemistry, , Jan-09, Volume: 57, Issue:1, 2014
Triazole-dithiocarbamate based selective lysine specific demethylase 1 (LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration.Journal of medicinal chemistry, , Nov-14, Volume: 56, Issue:21, 2013
Fluorinated phenylcyclopropylamines. 1. Synthesis and effect of fluorine substitution at the cyclopropane ring on inhibition of microbial tyramine oxidase.Journal of medicinal chemistry, , Mar-25, Volume: 47, Issue:7, 2004
Dual inhibitors of LSD1 and spermine oxidase.MedChemComm, , May-01, Volume: 10, Issue:5, 2019
3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors.MedChemComm, , Volume: 5, Issue:12, 2014
Overcoming undesirable hERG affinity by incorporating fluorine atoms: A case of MAO-B inhibitors derived from 1 H-pyrrolo-[3,2-c]quinolines.European journal of medicinal chemistry, , Jun-05, Volume: 236, 2022
Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy.European journal of medicinal chemistry, , Apr-05, Volume: 233, 2022
Synthesis and human monoamine oxidase inhibitory activity of novel C2-, C3- and C4-substituted phthalonitriles.Bioorganic & medicinal chemistry letters, , 10-15, Volume: 74, 2022
4-Oxoquinolines and monoamine oxidase: When tautomerism matters.European journal of medicinal chemistry, , Mar-05, Volume: 213, 2021
Design, synthesis and evaluation of novel dimethylamino chalcone-O-alkylamines derivatives as potential multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Apr-15, Volume: 216, 2021
Novel 1-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-indene-4-thiol derivatives as potent selective human monoamine oxidase B inhibitors: Design, SAR development, and biological evaluation.Bioorganic & medicinal chemistry letters, , 07-01, Volume: 43, 2021
Mapping Chromone-3-Phenylcarboxamide Pharmacophore: Journal of medicinal chemistry, , 08-12, Volume: 64, Issue:15, 2021
Pyrimido[1,2-b]indazole derivatives: Selective inhibitors of human monoamine oxidase B with neuroprotective activity.European journal of medicinal chemistry, , Jan-01, Volume: 209, 2021
Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 04-01, Volume: 35, 2021
[no title available]Journal of medicinal chemistry, , 02-13, Volume: 63, Issue:3, 2020
Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies.European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer's disease.European journal of medicinal chemistry, , Sep-15, Volume: 202, 2020
[no title available]European journal of medicinal chemistry, , Dec-15, Volume: 208, 2020
[no title available]European journal of medicinal chemistry, , Dec-01, Volume: 207, 2020
Design, synthesis and evaluation of flurbiprofen-clioquinol hybrids as multitarget-directed ligands against Alzheimer's disease.Bioorganic & medicinal chemistry, , 04-01, Volume: 28, Issue:7, 2020
Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease.Bioorganic & medicinal chemistry, , 04-15, Volume: 28, Issue:8, 2020
Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , May-15, Volume: 194, 2020
Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
(Pyrrolo-pyridin-5-yl)benzamides: BBB permeable monoamine oxidase B inhibitors with neuroprotective effect on cortical neurons.European journal of medicinal chemistry, , Jan-15, Volume: 162, 2019
Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Sep-15, Volume: 178, 2019
Carboxamides vs. methanimines: Crystal structures, binding interactions, photophysical studies, and biological evaluation of (indazole-5-yl)methanimines as monoamine oxidase B and acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Oct-01, Volume: 179, 2019
The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 10-01, Volume: 29, Issue:19, 2019
Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies.Bioorganic & medicinal chemistry, , 04-01, Volume: 27, Issue:7, 2019
Discovery of coumarin Mannich base derivatives as multifunctional agents against monoamine oxidase B and neuroinflammation for the treatment of Parkinson's disease.European journal of medicinal chemistry, , Jul-01, Volume: 173, 2019
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.European journal of medicinal chemistry, , Oct-05, Volume: 158, 2018
Design, synthesis and bioevalucation of novel 2,3-dihydro-1H-inden-1-amine derivatives as potent and selective human monoamine oxidase B inhibitors based on rasagiline.European journal of medicinal chemistry, , Feb-10, Volume: 145, 2018
4-tert-Pentylphenoxyalkyl derivatives - Histamine HBioorganic & medicinal chemistry letters, , 12-15, Volume: 28, Issue:23-24, 2018
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.Bioorganic & medicinal chemistry, , 05-01, Volume: 26, Issue:8, 2018
Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment.Bioorganic & medicinal chemistry, , 03-01, Volume: 26, Issue:5, 2018
Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer's disease.Bioorganic chemistry, , Volume: 71, 2017
Synthesis and pharmacological evaluation of novel chromone derivatives as balanced multifunctional agents against Alzheimer's disease.Bioorganic & medicinal chemistry, , 07-15, Volume: 25, Issue:14, 2017
Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 02-01, Volume: 25, Issue:3, 2017
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 27, Issue:22, 2017
Coumarin versus Chromone Monoamine Oxidase B Inhibitors: Quo Vadis?Journal of medicinal chemistry, , 08-24, Volume: 60, Issue:16, 2017
MAO enzymes inhibitory activity of new benzimidazole derivatives including hydrazone and propargyl side chains.European journal of medicinal chemistry, , May-05, Volume: 131, 2017
Discovery of highly selective and potent monoamine oxidase B inhibitors: Contribution of additional phenyl rings introduced into 2-aryl-1,3,4-oxadiazin-5(6H)-one.European journal of medicinal chemistry, , Apr-21, Volume: 130, 2017
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jan-27, Volume: 126, 2017
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 06-15, Volume: 25, Issue:12, 2017
Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 27, Issue:22, 2017
Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.Bioorganic & medicinal chemistry, , 03-15, Volume: 25, Issue:6, 2017
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 27, Issue:4, 2017
Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties.Bioorganic & medicinal chemistry, , 01-15, Volume: 25, Issue:2, 2017
Neuroprotective effects of benzyloxy substituted small molecule monoamine oxidase B inhibitors in Parkinson's disease.Bioorganic & medicinal chemistry, , 11-15, Volume: 24, Issue:22, 2016
Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 05-15, Volume: 24, Issue:10, 2016
Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors.Journal of medicinal chemistry, , 06-23, Volume: 59, Issue:12, 2016
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.Bioorganic & medicinal chemistry, , Feb-15, Volume: 23, Issue:4, 2015
Development of a novel fluorine-18 labeled deuterated fluororasagiline ([(18)F]fluororasagiline-D2) radioligand for PET studies of monoamino oxidase B (MAO-B).Bioorganic & medicinal chemistry, , Nov-01, Volume: 21, Issue:21, 2013
Novel (coumarin-3-yl)carbamates as selective MAO-B inhibitors: synthesis, in vitro and in vivo assays, theoretical evaluation of ADME properties and docking study.European journal of medicinal chemistry, , Volume: 63, 2013
Multitarget-directed benzylideneindanone derivatives: anti-β-amyloid (Aβ) aggregation, antioxidant, metal chelation, and monoamine oxidase B (MAO-B) inhibition properties against Alzheimer's disease.Journal of medicinal chemistry, , Oct-11, Volume: 55, Issue:19, 2012
Synthesis and evaluation of [¹⁸F]fluororasagiline, a novel positron emission tomography (PET) radioligand for monoamine oxidase B (MAO-B).Bioorganic & medicinal chemistry, , May-01, Volume: 20, Issue:9, 2012
Multi-target-directed ligands to combat neurodegenerative diseases.Journal of medicinal chemistry, , Feb-14, Volume: 51, Issue:3, 2008
Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors.The Journal of biological chemistry, , Apr-22, Volume: 280, Issue:16, 2005
Binding of rasagiline-related inhibitors to human monoamine oxidases: a kinetic and crystallographic analysis.Journal of medicinal chemistry, , Dec-29, Volume: 48, Issue:26, 2005
Docking studies on monoamine oxidase-B inhibitors: estimation of inhibition constants (K(i)) of a series of experimentally tested compounds.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 15, Issue:20, 2005
Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues.Journal of medicinal chemistry, , Mar-25, Volume: 47, Issue:7, 2004
Novel monoamine oxidase inhibitors based on the privileged 2-imidazoline molecular framework.Bioorganic & medicinal chemistry letters, , 01-01, Volume: 29, Issue:1, 2019
Design, synthesis and bioevalucation of novel 2,3-dihydro-1H-inden-1-amine derivatives as potent and selective human monoamine oxidase B inhibitors based on rasagiline.European journal of medicinal chemistry, , Feb-10, Volume: 145, 2018
Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 19, Issue:2, 2009
Isolation of Acacetin from Calea urticifolia with Inhibitory Properties against Human Monoamine Oxidase-A and -B.Journal of natural products, , 10-28, Volume: 79, Issue:10, 2016
A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors.Bioorganic & medicinal chemistry, , Volume: 18, Issue:3, 2010
Isolation of Acacetin from Calea urticifolia with Inhibitory Properties against Human Monoamine Oxidase-A and -B.Journal of natural products, , 10-28, Volume: 79, Issue:10, 2016
A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors.Bioorganic & medicinal chemistry, , Volume: 18, Issue:3, 2010
Synthesis and evaluation of β-carboline derivatives as potential monoamine oxidase inhibitors.Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
Binding of beta-carbolines at 5-HT(2) serotonin receptors.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 13, Issue:24, 2003
Potent selective monoamine oxidase B inhibition by maackiain, a pterocarpan from the roots of Sophora flavescens.Bioorganic & medicinal chemistry letters, , 10-01, Volume: 26, Issue:19, 2016
The mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway: a potential site of action of daidzin.Journal of medicinal chemistry, , Nov-02, Volume: 43, Issue:22, 2000
Synthesis of potential antidipsotropic isoflavones: inhibitors of the mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway.Journal of medicinal chemistry, , Sep-27, Volume: 44, Issue:20, 2001
The mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway: a potential site of action of daidzin.Journal of medicinal chemistry, , Nov-02, Volume: 43, Issue:22, 2000
Synthesis of a series of unsaturated ketone derivatives as selective and reversible monoamine oxidase inhibitors.Bioorganic & medicinal chemistry, , Oct-01, Volume: 23, Issue:19, 2015
Synthesis of potential antidipsotropic isoflavones: inhibitors of the mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway.Journal of medicinal chemistry, , Sep-27, Volume: 44, Issue:20, 2001
Structure-activity relationship and docking studies of thiazolidinedione-type compounds with monoamine oxidase B.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 21, Issue:16, 2011
Identification of novel monoamine oxidase B inhibitors by structure-based virtual screening.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 20, Issue:17, 2010
Discovery of monoamine oxidase inhibitors by medicinal chemistry approaches.MedChemComm, , Jan-01, Volume: 10, Issue:1, 2019
Synthesis of (E)-8-(3-chlorostyryl)caffeine analogues leading to 9-deazaxanthine derivatives as dual A(2A) antagonists/MAO-B inhibitors.Journal of medicinal chemistry, , Feb-14, Volume: 56, Issue:3, 2013
Discovery of monoamine oxidase inhibitors by medicinal chemistry approaches.MedChemComm, , Jan-01, Volume: 10, Issue:1, 2019
Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies.Bioorganic & medicinal chemistry, , 04-01, Volume: 27, Issue:7, 2019
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.Bioorganic & medicinal chemistry, , Feb-15, Volume: 23, Issue:4, 2015
1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases.Bioorganic & medicinal chemistry, , Dec-01, Volume: 21, Issue:23, 2013
Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones.Journal of medicinal chemistry, , Jun-13, Volume: 56, Issue:11, 2013
Synthesis of (E)-8-(3-chlorostyryl)caffeine analogues leading to 9-deazaxanthine derivatives as dual A(2A) antagonists/MAO-B inhibitors.Journal of medicinal chemistry, , Feb-14, Volume: 56, Issue:3, 2013
Inhibition of monoamine oxidase by (E)-styrylisatin analogues.Bioorganic & medicinal chemistry letters, , May-01, Volume: 19, Issue:9, 2009
Multi-target-directed ligands to combat neurodegenerative diseases.Journal of medicinal chemistry, , Feb-14, Volume: 51, Issue:3, 2008
Chromenylchalcones with inhibitory effects on monoamine oxidase B.Bioorganic & medicinal chemistry, , Dec-15, Volume: 21, Issue:24, 2013
Chalcones: a valid scaffold for monoamine oxidases inhibitors.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
[no title available]European journal of medicinal chemistry, , Mar-25, Volume: 148, 2018
Combining monoamine oxidase B and semicarbazide-sensitive amine oxidase enzyme inhibition to address inflammatory disease.Bioorganic & medicinal chemistry letters, , 10-15, Volume: 74, 2022
The discovery and development of selective 3-fluoro-4-aryloxyallylamine inhibitors of the amine oxidase activity of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1).Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 22, Issue:12, 2012
Structural and mechanistic studies of mofegiline inhibition of recombinant human monoamine oxidase B.Journal of medicinal chemistry, , Dec-25, Volume: 51, Issue:24, 2008
Imidazoline binding sites (IBS) profile modulation: key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
2-(2-Phenylcyclopropyl)imidazolines: reversed enantioselective interaction at I(1) and I(2) imidazoline receptors.Journal of medicinal chemistry, , Jul-29, Volume: 42, Issue:15, 1999
Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy.Bioorganic & medicinal chemistry letters, , 02-01, Volume: 30, Issue:3, 2020
Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.Journal of medicinal chemistry, , Dec-26, Volume: 57, Issue:24, 2014
Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.European journal of medicinal chemistry, , Mar-21, Volume: 75, 2014
[no title available]Journal of medicinal chemistry, , 03-10, Volume: 65, Issue:5, 2022
Tranylcypromine and 6-trifluoroethyl thienopyrimidine hybrid as LSD1 inhibitor.Bioorganic & medicinal chemistry letters, , 03-15, Volume: 29, Issue:6, 2019
Enables
This protein enables 7 target(s):
| Target | Category | Definition |
|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| primary amine oxidase activity | molecular function | Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide. [EC:1.4.3.21] |
| electron transfer activity | molecular function | A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. [Wikipedia:Electron_transfer] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
| aliphatic amine oxidase activity | molecular function | Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+. [MetaCyc:AMINEOXID-RXN] |
| monoamine oxidase activity | molecular function | Catalysis of the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2. [GOC:pr, PMID:15279562, PMID:16129825] |
| flavin adenine dinucleotide binding | molecular function | Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. [GOC:ai, GOC:imk, ISBN:0198506732] |
Located In
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| mitochondrial envelope | cellular component | The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. [GOC:ai, GOC:pz] |
| mitochondrial outer membrane | cellular component | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. [GOC:ai] |
| dendrite | cellular component | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] |
| neuronal cell body | cellular component | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
Involved In
This protein is involved in 13 target(s):
| Target | Category | Definition |
|---|
| response to xenobiotic stimulus | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc] |
| response to toxic substance | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. [GOC:lr] |
| response to aluminum ion | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus. [GOC:sm] |
| response to selenium ion | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion. [GOC:mg] |
| negative regulation of serotonin secretion | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin. [GOC:ef] |
| phenylethylamine catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds. [GOC:jl, ISBN:0395825172] |
| substantia nigra development | biological process | The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis). [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343, ISBN:0878937420] |
| response to lipopolysaccharide | biological process | Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:add, ISBN:0721601464] |
| dopamine catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. [GOC:jl, ISBN:0198506732] |
| response to ethanol | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. [GOC:go_curators] |
| positive regulation of dopamine metabolic process | biological process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving dopamine. [GOC:go_curators] |
| hydrogen peroxide biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. [GOC:ai] |
| response to corticosterone | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses. [PMID:15240347] |