A succinate-semialdehyde dehydrogenase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51649]
EC 1.2.1.24;
Aldehyde dehydrogenase family 5 member A1;
NAD(+)-dependent succinic semialdehyde dehydrogenase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 4-hydroxybenzyl alcohol | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| 4-hydroxybenzaldehyde | Homo sapiens (human) | IC50 | 24.7000 | 1 | 1 |
| 4-hydroxybenzoic acid | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| 4-aminobenzoic acid | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| vanillin | Homo sapiens (human) | IC50 | 15.6000 | 1 | 1 |
| 4-hydroxypropiophenone | Homo sapiens (human) | IC50 | 293.0000 | 1 | 1 |
| 4-hydroxyacetophenone | Homo sapiens (human) | IC50 | 166.0000 | 1 | 1 |
| 4-anisaldehyde | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| 4-hydroxybenzylamine | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| gastrodin | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| scutellarein | Homo sapiens (human) | IC50 | 7,200.0000 | 1 | 1 |
| helicide | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
This protein enables 2 target(s):
| Target | Category | Definition |
|---|---|---|
| succinate-semialdehyde dehydrogenase (NAD+) activity | molecular function | Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+. [RHEA:13217] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| mitochondrial matrix | cellular component | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732] |
| synapse | cellular component | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| succinate metabolic process | biological process | The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle. [ISBN:0198506732] |
| glutamate metabolic process | biological process | The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. [GOC:go_curators] |
| central nervous system development | biological process | The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. [GOC:bf, GOC:jid, ISBN:0582227089] |
| gamma-aminobutyric acid catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. [GOC:ai] |
| post-embryonic development | biological process | The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. [GOC:go_curators] |
| synaptic transmission, GABAergic | biological process | The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:dos, ISBN:0126603030] |