valproic acid has been researched along with Necrosis in 21 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid (VPA) is a drug known for idiosyncratic hepatotoxicity and is associated with oxidative stress." | 5.36 | Role of oxidative metabolism in the effect of valproic acid on markers of cell viability, necrosis, and oxidative stress in sandwich-cultured rat hepatocytes. ( Abbott, FS; Chang, TK; Karagiozov, S; Kiang, TK; Surendradoss, J; Teng, XW, 2010) |
| "The authors report a case of fatal hepatic failure in a 19-year old young man suffering from absence seizures and treated for two months with valproic acid (VPA)." | 3.69 | [Fatal hepatic necrosis during treatment with sodium valproate]. ( Benaguida, M; Chlihi, A; Miguil, M; Mjahed, K; Moutawakkil, S; Sarf, I, 1995) |
| "Exencephaly/anencephaly is one of the leading causes of neonatal mortality and the most extreme open neural tube defect with no current treatments and limited mechanistic understanding." | 1.51 | Cell necrosis, intrinsic apoptosis and senescence contribute to the progression of exencephaly to anencephaly in a mice model of congenital chranioschisis. ( Duru, S; Fernandez-Alonso, I; Fernandez-Martin, A; Figueira, RL; Marotta, M; Oria, M; Peiro, JL; Sbragia, L; Scorletti, F; Shaaban, AF; Turner, LE, 2019) |
| "Valproic acid-treated animals developed biochemical evidence of FS as judged by elevated serum gamma-glutamyl transferase (γ-GT), alkaline phosphatase (ALP), creatinine (Cr), and blood urea nitrogen (BUN) along with hypokalaemia, hypophosphataemia, and a decrease in serum uric acid." | 1.48 | Mechanism of valproic acid-induced Fanconi syndrome involves mitochondrial dysfunction and oxidative stress in rat kidney. ( Heidari, R; Jafari, F; Khodaei, F; Niknahad, H; Shirazi Yeganeh, B, 2018) |
| "Valproic acid (VPA) is a drug known for idiosyncratic hepatotoxicity and is associated with oxidative stress." | 1.36 | Role of oxidative metabolism in the effect of valproic acid on markers of cell viability, necrosis, and oxidative stress in sandwich-cultured rat hepatocytes. ( Abbott, FS; Chang, TK; Karagiozov, S; Kiang, TK; Surendradoss, J; Teng, XW, 2010) |
| "We report 2 siblings with Alpers disease who were discordant for exposure to valproate (VPA)." | 1.30 | Valproate-induced liver failure in one of two siblings with Alpers disease. ( Armstrong, DL; Burke, B; Dobyns, WB; Schwabe, MJ, 1997) |
| "We report a fatal case of haemorrhagic pancreatic necrosis in a 15-year-old mentally retarded epileptic male who had been taking sodium valproate (VPA) in the recommended dosage for one and a half years." | 1.29 | [Fatal pancreatitis associated with valproate therapy]. ( Engelmann, MD; Henriksen, SD; Tingsgaard, LK, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (9.52) | 18.7374 |
| 1990's | 7 (33.33) | 18.2507 |
| 2000's | 4 (19.05) | 29.6817 |
| 2010's | 7 (33.33) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Oria, M | 1 |
| Duru, S | 1 |
| Figueira, RL | 1 |
| Scorletti, F | 1 |
| Turner, LE | 1 |
| Fernandez-Alonso, I | 1 |
| Fernandez-Martin, A | 1 |
| Marotta, M | 1 |
| Sbragia, L | 1 |
| Shaaban, AF | 1 |
| Peiro, JL | 1 |
| Ala, M | 1 |
| Mohammad Jafari, R | 1 |
| Nematian, H | 1 |
| Ganjedanesh, MR | 1 |
| Dehpour, AR | 1 |
| Booth, L | 1 |
| Roberts, JL | 1 |
| Conley, A | 1 |
| Cruickshanks, N | 1 |
| Ridder, T | 1 |
| Grant, S | 1 |
| Poklepovic, A | 1 |
| Dent, P | 1 |
| Sharifulina, SA | 1 |
| Komandirov, MA | 1 |
| Uzdensky, AB | 1 |
| Rubner, Y | 1 |
| Muth, C | 1 |
| Strnad, A | 1 |
| Derer, A | 1 |
| Sieber, R | 1 |
| Buslei, R | 1 |
| Frey, B | 1 |
| Fietkau, R | 1 |
| Gaipl, US | 1 |
| Bollino, D | 1 |
| Balan, I | 1 |
| Aurelian, L | 1 |
| Heidari, R | 1 |
| Jafari, F | 1 |
| Khodaei, F | 1 |
| Shirazi Yeganeh, B | 1 |
| Niknahad, H | 1 |
| Kiang, TK | 1 |
| Teng, XW | 2 |
| Karagiozov, S | 1 |
| Surendradoss, J | 1 |
| Chang, TK | 2 |
| Abbott, FS | 2 |
| Sadovnikova, IV | 1 |
| Tong, V | 1 |
| Williams, JA | 1 |
| Barreiro, CJ | 1 |
| Nwakanma, LU | 1 |
| Lange, MS | 1 |
| Kratz, LE | 1 |
| Blue, ME | 1 |
| Berrong, J | 1 |
| Patel, ND | 1 |
| Gott, VL | 1 |
| Troncoso, JC | 1 |
| Johnston, MV | 1 |
| Baumgartner, WA | 1 |
| Kolts, BE | 1 |
| Langfitt, M | 1 |
| Ware, S | 1 |
| Millward-Sadler, GH | 1 |
| Miguil, M | 1 |
| Chlihi, A | 1 |
| Mjahed, K | 1 |
| Sarf, I | 1 |
| Moutawakkil, S | 1 |
| Benaguida, M | 1 |
| Tobias, JD | 1 |
| Capers, C | 1 |
| Sims, P | 1 |
| Holcomb, GW | 1 |
| Engelmann, MD | 1 |
| Henriksen, SD | 1 |
| Tingsgaard, LK | 1 |
| Puri, AS | 1 |
| Sharma, BC | 1 |
| Khan, EM | 1 |
| Saraswat, VA | 1 |
| Nevoral, J | 1 |
| Janda, J | 1 |
| Hanika, J | 1 |
| Svec, M | 1 |
| Honzová, S | 1 |
| Schwabe, MJ | 1 |
| Dobyns, WB | 1 |
| Burke, B | 1 |
| Armstrong, DL | 1 |
| Munhoz, RP | 1 |
| dos Santos, ML | 1 |
| Hernández-Fustes, OJ | 1 |
| Bell, EA | 1 |
| Shaefer, MS | 1 |
| Markin, RS | 1 |
| Wood, RP | 1 |
| Langnas, AN | 1 |
| Stratta, RJ | 1 |
| Shaw, BW | 1 |
21 other studies available for valproic acid and Necrosis
| Article | Year |
|---|---|
Cell necrosis, intrinsic apoptosis and senescence contribute to the progression of exencephaly to anencephaly in a mice model of congenital chranioschisis.
Topics: Amniotic Fluid; Anencephaly; Animals; Apoptosis; Brain; Caspase 3; Caspase 9; Cellular Senescence; C | 2019 |
Sodium Valproate Improves Skin Flap Survival via Gamma-Aminobutyric Acid and Histone Deacetylase Inhibitory System.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Graft Survival; Histone Deacetylases; Huma | 2020 |
HDAC inhibitors enhance the lethality of low dose salinomycin in parental and stem-like GBM cells.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Drug Synergism; Fem | 2014 |
Epigenetic regulation of death of crayfish glial cells but not neurons induced by photodynamic impact.
Topics: Action Potentials; Animals; Apoptosis; Astacoidea; Azacitidine; Decitabine; DNA Methylation; Enzyme | 2014 |
Fractionated radiotherapy is the main stimulus for the induction of cell death and of Hsp70 release of p53 mutated glioblastoma cell lines.
Topics: Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Death; Cell Line, Tumor; Dacarba | 2014 |
Valproic acid induces neuronal cell death through a novel calpain-dependent necroptosis pathway.
Topics: Animals; Apoptosis; Calpain; Cell Death; Cell Line; Dose-Response Relationship, Drug; Enzyme Activat | 2015 |
Mechanism of valproic acid-induced Fanconi syndrome involves mitochondrial dysfunction and oxidative stress in rat kidney.
Topics: Adenosine Triphosphate; Animals; Atrophy; Disease Models, Animal; Fanconi Syndrome; Glutathione; Kid | 2018 |
Role of oxidative metabolism in the effect of valproic acid on markers of cell viability, necrosis, and oxidative stress in sandwich-cultured rat hepatocytes.
Topics: Animals; Biomarkers; Cell Culture Techniques; Cell Survival; Cells, Cultured; Dose-Response Relation | 2010 |
[Experimental validation of regeneration therapy in hepatitis caused by toxic medication].
Topics: Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Hepatocytes; Liver Regeneration; N | 2003 |
Valproic acid I: time course of lipid peroxidation biomarkers, liver toxicity, and valproic acid metabolite levels in rats.
Topics: Animals; Anticonvulsants; Biomarkers; Dinoprost; Fatty Liver; Glutathione Transferase; Lipid Peroxid | 2005 |
Valproic acid prevents brain injury in a canine model of hypothermic circulatory arrest: a promising new approach to neuroprotection during cardiac surgery.
Topics: Animals; Apoptosis; Aspartic Acid; Behavior, Animal; Biomarkers; Brain; Brain Chemistry; Brain Damag | 2006 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv | 1984 |
Acute liver disease associated with sodium valproate.
Topics: Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Epilepsy; Fat | 1980 |
[Fatal hepatic necrosis during treatment with sodium valproate].
Topics: Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Fatal Outcome; Hepatic Encephalopath | 1995 |
Necrotizing pancreatitis after 10 years of therapy with valproic acid.
Topics: Child; Humans; Male; Necrosis; Pancreatitis; Seizures; Time Factors; Valproic Acid | 1995 |
[Fatal pancreatitis associated with valproate therapy].
Topics: Acute Disease; Adolescent; Fatal Outcome; Humans; Male; Necrosis; Pancreatitis; Valproic Acid | 1995 |
Fatal fulminant hepatic failure due to sodium valproate in an adolescent.
Topics: Adolescent; Brain Diseases; Drug Therapy, Combination; Fatal Outcome; Hepatic Encephalopathy; Humans | 1994 |
[Acute reversible liver necrosis after valproate therapy (immunologic hypersensitivity)].
Topics: Child; Drug Hypersensitivity; Epilepsy; Humans; Liver; Liver Cirrhosis; Male; Necrosis; Transaminase | 1993 |
Valproate-induced liver failure in one of two siblings with Alpers disease.
Topics: Anticonvulsants; Child, Preschool; Diffuse Cerebral Sclerosis of Schilder; Fatal Outcome; Female; Hu | 1997 |
[Fatal necro-hemorrhagic pancreatitis related to sodium valproate: case report].
Topics: Acute Disease; Anticonvulsants; Child; Epilepsy; Fatal Outcome; Humans; Male; Necrosis; Pancreatitis | 2001 |
Treatment of valproic acid-associated hepatic failure with orthotopic liver transplantation.
Topics: Adult; Female; Hepatic Encephalopathy; Humans; Liver Transplantation; Necrosis; Risk Factors; Valpro | 1992 |