A sialidase-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99519]
EC 3.2.1.18;
Acetylneuraminyl hydrolase;
G9 sialidase;
Lysosomal sialidase;
N-acetyl-alpha-neuraminidase 1
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| zanamivir | Homo sapiens (human) | IC50 | 952.1667 | 6 | 5 |
| oseltamivir | Homo sapiens (human) | IC50 | 3,666.6667 | 3 | 3 |
| 2-deoxy-2,3-dehydro-n-acetylneuraminic acid | Homo sapiens (human) | IC50 | 82.2727 | 11 | 10 |
| 2-deoxy-2,3-dehydro-n-acetylneuraminic acid | Homo sapiens (human) | Ki | 12.0000 | 2 | 2 |
| bcx 1812 | Homo sapiens (human) | IC50 | 500.0000 | 2 | 2 |
| n-acetylneuraminic acid | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| n-acetylneuraminic acid | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| 4-amino-2-deoxy-2,3-didehydro-n-acetylneuraminic acid | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
This protein enables 6 target(s):
| Target | Category | Definition |
|---|---|---|
| exo-alpha-sialidase activity | molecular function | Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. [EC:3.2.1.18] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| alpha-sialidase activity | molecular function | Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids. [GOC:mah] |
| exo-alpha-(2->3)-sialidase activity | molecular function | Catalysis of the hydrolysis of alpha-(2->3)-glycosidic linkages of terminal sialic residues in substrates. [EC:3.2.1.18, GOC:mengo_curators] |
| exo-alpha-(2->6)-sialidase activity | molecular function | Catalysis of the hydrolysis of alpha-(2->6)-glycosidic linkages of terminal sialic residues in substrates. [EC:3.2.1.18, GOC:mengo_curators] |
| exo-alpha-(2->8)-sialidase activity | molecular function | Catalysis of the hydrolysis of alpha-(2->8)-glycosidic linkages of terminal sialic residues in substrates. [EC:3.2.1.18, GOC:mengo_curators] |
This protein is located in 9 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| lysosome | cellular component | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732] |
| lysosomal membrane | cellular component | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| cell junction | cellular component | A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. [GOC:aruk, GOC:bc, GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732, PMID:26820516, PMID:28096264] |
| specific granule lumen | cellular component | The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. [GOC:bf, PMID:7334549] |
| lysosomal lumen | cellular component | The volume enclosed within the lysosomal membrane. [GOC:jl, PMID:15213228] |
| intracellular membrane-bounded organelle | cellular component | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is active in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| lysosome | cellular component | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| oligosaccharide catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. [ISBN:0198506732] |
| ganglioside catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of ganglioside, a ceramide oligosaccharide carrying, in addition to other sugar residues, one or more sialic residues. [ISBN:0198547684] |