ascorbic acid profile

Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Related Flora

Pathways (29)

ascorbic acid is involved in 29 pathway(s), involving a total of 354 unique proteins and 1483 unique compounds

Flora	Rank	Flora Definition	Family	Family Definition
Citrus	genus	A plant genus of the family RUTACEAE. They bear the familiar citrus fruits including oranges, grapefruit, lemons, and limes. There are many hybrids which makes the nomenclature confusing.[MeSH]	Rutaceae	A plant family in the order Sapindales that grows in warmer regions and has conspicuous flowers.[MeSH]

ID Source	ID
PubMed CID	54670067
CHEMBL ID	40274
CHEBI ID	29073
CHEBI ID	22652
CHEBI ID	176783
SCHEMBL ID	785
SCHEMBL ID	4430
MeSH ID	M0001797

Synonym
(2r)-2-[(1s)-1,2-dihydroxyethyl]-4,5-dihydroxy-furan-3-one
MLS002153776
smr001233160
e300
acido ascorbico
acide ascorbique
e-300
acidum ascorbinicum
acidum ascorbicum
l-threo-hex-2-enono-1,4-lactone
ascorbinsaeure
(5r)-5-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxyfuran-2(5h)-one
CHEBI:29073 ,
l-(+)-ascorbic acid
proscorbin
cevex
antiscorbic vitamin
cee-vite
cenetone
cebione
vicelat
ascorb
hybrin
vitacee
3-keto-l-gulofuranolactone
ascor-b.i.d.
viscorin
celaskon
celin
vitacimin
vitamisin
cenolate
nsc-33832
redoxon
ascorteal
ascorin
cevitan
ceglion
cetane-caps td
component of cortalex
l-lyxoascorbic acid
cevi-bid
cereon
cegiolan
cebid
cetemican
ido-c
cevital
antiscorbutic vitamin
component of e and c-level
l(+)-ascorbic acid
planavit c
citriscorb
ce lent
meri-c
l-xyloascorbic acid
hicee
vitace
xitix
arco-cee
cevatine
cergona
cipca
scorbu-c
nci-c54808
cescorbat
adenex
component of ferancee
roscorbic
cevitamin
c-quin
cetamid
c-level
ribena
natrascorb injectable
l-3-ketothreohexuronic acid lactone
c-long
secorbate
cemagyl
vitacin
dora-c-500
ascoltin
ce-mi-lin
ascorbicap
ce-vi-sol
cantaxin
cemill
NSC33832 ,
ascorbajen
liqui-cee
davitamon c
colascor
cebicure
nsc-218455
D00018
ascor (tn)
ascorbic acid (jp17/usp/inn)
ascoltin (tn)
ascorbicap (tn)
hex-2-enonic acid gamma-lactone, l-threo-
ascorbicab
einecs 200-066-2
cevibid
kyselina askorbova [czech]
ferancee
acide ascorbique [inn-french]
stuartinic
tolfrinic
acido ascorbico [inn-spanish]
chromagen
acidum ascorbicum [inn-latin]
nsc 33832
scorbacid
cortalex
PRESTWICK3_000325
BPBIO1_000363
l-threo-ascorbic acid
(2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one
cevitamic acid
cevimin
cantan
component of endoglobin forte
laroscorbine
cecon
vicomin c
c-span
vitascorbol
cebion
ascorvit
viforcit
testascorbic
catavin c
cee-caps td
allercorb
natrascorb
lemascorb
ascorbutina
concemin
c-vimin
ciamin
iron(ii) ascorbate
cevitex
3-oxo-l-gulofuranolactone
rovimix c
vasc
(+)-ascorbic acid
ronotec 100
citrovit
hsdb 818
fema no. 2109
juvamine
scorbu c
chewcee
cewin
ccris 57
caswell no. 061b
duoscorb
l-threo-hex-2-enonic acid, gamma-lactone
cetane-caps tc
3-oxo-l-gulofuranolactone (enol form)
rontex 100
NCGC00091517-01
2-(1,2-dihydroxyethyl)-4,5-dihydroxyfuran-3-one
AB00376923
l-ascorbic acid
ascorbic acid
C00072
l-ascorbate
50-81-7
vitamin c
l-ascorbic acid, reagent grade
l-ascorbic acid, meets usp testing specifications
l-ascorbic acid, analytical standard
l-ascorbic acid, reagent grade, crystalline
l-ascorbic acid, bioxtra, >=99.0%, crystalline
l-ascorbic acid, plant cell culture tested
l-ascorbic acid, powder, cell culture tested, gamma-irradiated
l-ascorbic acid, suitable for cell culture, suitable for plant cell culture, >=98%
l-ascorbic acid, fcc, fg
DB00126
l-ascorbic acid, acs reagent, >=99%
NCGC00164357-01
l-ascorbic acid, free acid
BSPBIO_000329
NCGC00091517-02
acid, ascorbic
ascorbyl radical
l-ascorbic acid, bioultra, >=99.5% (rt)
l-ascorbic acid, puriss. p.a., >=99.0% (rt)
l-ascorbic acid, 99%
l-ascorbic acid, puriss. p.a., acs reagent, reag. iso, reag. ph. eur., 99.7-100.5% (oxidimetric)
47A605F0-4187-47A8-B0CE-F9E7DA1B0076
A0537
(r)-5-((s)-1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5h)-one
ascorbic acid [ban:inn:jan]
BMSE000182
kyselina askorbova
ins-300
ins no.300
ascorbic acid (vit c)
vitamin c (as ascorbic acid)
ascorbicum acidum
ascorbic acid, l-
(2r)-2-[(1s)-1,2-dihydroxyethyl]-4,5-dihydroxyfuran-3-one
NCGC00091517-03
NCGC00188972-01
HMS2096A11
ester c
dtxcid90106
dtxsid5020106 ,
tox21_302958
NCGC00256504-01
tox21_112104
NCGC00259676-01
tox21_202127
ester-c
53262-66-1
l-ascorbic acid, mixt. with vitamin b
parentrovite
tox21_110315
l-ascorbic acid, free radical form
6730-29-6
HMS2231N16
unii-pq6ck8pd0r
pq6ck8pd0r ,
ascorbic acid [usp:inn:ban:jan]
nsc 218455
ascor
BP-12831
ascorbic acid [mi]
ascorbic acid [vandf]
ascorbic acid [usp monograph]
ascorbic acid [fcc]
acidum ascorbicum [who-ip latin]
ascorbic acid [ep monograph]
2,3-dehydro-l-threo-hexono-1,4-lactone
ascorbic acid [ii]
ascorbic acid [who-ip]
ascorbic acid [inn]
ascorbic acid [hsdb]
ascorbic acid [who-dd]
ascorbic acid [orange book]
(5r)-5-((1s)-1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5h)-one
ascorbic acid [fhfi]
ascorbic acid [usp-rs]
ascorbic acid [jan]
ascorbic acid [inci]
ascorbic acid [mart.]
vitamin c [vandf]
l-threoascorbic acid
antiscorbutic factor
S3114
CHEMBL40274
[14c]ascorbic acid
gtpl4532
gtpl4781
(5r)-5-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2,5-dihydrofuran-2-one
[14c]-ascorbic acid
CCG-207946
HY-B0166
SCHEMBL785
SCHEMBL4430
NCGC00091517-06
tox21_112104_1
3EKA
2-(1,2-dihydroxyethyl)-4,5-dihydroxy-furan-3-one
CIWBSHSKHKDKBQ-JLAZNSOCSA-N
ascorbic acid, british pharmacopoeia (bp) reference standard
HB1238
AB00376923_05
AB00376923_04
ascorbic acid dc97sf
hex-1-enofuranos-3-ulose
mfcd00064328
l-ascorbic acid, tested according to ph.eur.
ascorbic acid, european pharmacopoeia (ep) reference standard
l-ascorbic acid, anhydrous, free-flowing, redi-dri(tm), acs reagent, >=99%
l-ascorbic acid, >=99.0%
ascorbic acid, united states pharmacopeia (usp) reference standard
l-ascorbic acid, jis special grade, >=99.0%
l-ascorbic acid, certified reference material, tracecert(r)
(r)-5-(1,2-dihydroxy-ethyl)-3,4-dihydroxy-5h-furan-2-one
l-ascorbic acid acs reagent grade
l-ascorbic acid, p.a., acs reagent, reag. iso, 99.7%
l-ascorbic acid, vetec(tm) reagent grade, 99%
l-ascorbic acid, p.a., acs reagent, 99.0%
l-ascorbic acid, ar, >=99.5%
ascorbic acid (l-ascorbic acid; vitamin c)
.ascorbinsaure
HMS3713A11
gamma-lactone l-threo-hex-2-enonate
cevitamate
l-lyxoascorbate
gamma-lactone l-threo-hex-2-enonic acid
l-(+)-ascorbate
l(+)-ascorbate
(+)-ascorbate
l-xyloascorbate
SW198791-2
l-threoascorbic acid,antiscorbutic factor,vitamin c;(r)-5-((s)-1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5h)-one
(5r)-5-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxyfuran-2(5h)-one (non-preferred name)
vitamin c (ascorbic acid)
vitamin c,(s)
DTXSID50986567
Q27101942
l-ascorbic acid 1000 microg/ml in acetonitrile
BCP27915
Q199678
4-((e)-2-[(2-hydroxyethyl)sulfanyl]diazenyl)benzenecarboxylicacid
l-ascorbic acid, cell culture
AKOS016843589
EN300-708766
E80759
l-ascorbic acid (gmp)
CS-0626121
HY-B0166G
hicell
dr cellapy sr premium
ascorbic acid (usp:inn:ban:jan)
asorbicap
celladix c.e.f advanced brightening ampoule
ascorbic acid (mart.)
chebi:22652
ascorbic acid (ii)
chebi:176783
vitamina c
dtxcid50820452
ascorbinezuur
acidum ascorbicum (inn-latin)
clairfore
aromacura shower filter
neo-valdrin
cleanflex
ascorbic acid1505
vitamine c
ascorbic acid (ep monograph)
vit c
ascorbic acid (usp-rs)
vita rich
ascorbic acid (usp monograph)
acido ascorbico (inn-spanish)
new clairfore
acide ascorbique (inn-french)

Role	Description
coenzyme	A low-molecular-weight, non-protein organic compound participating in enzymatic reactions as dissociable acceptor or donor of chemical groups or electrons.
flour treatment agent	A food additive which is added to flour or dough to improve baking quality and/or colour.
food antioxidant	An antioxidant that used as a food additives to help guard against food deterioration.
plant metabolite	Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
cofactor	An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group).
skin lightening agent	Any cosmetic used to lighten the colour of skin by reducing the concentration of melanin.
geroprotector	Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.
food colour retention agent	A food additive that intensifies, retains or stabilises the colour of a food.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
ascorbic acid
vitamin C	Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathway	Proteins	Compounds
Extracellular matrix organization	135	20
Collagen formation	19	14
Collagen biosynthesis and modifying enzymes	8	9
Tyrosine Metabolism	16	57
Catecholamine Biosynthesis	3	14
Aromatic L-Aminoacid Decarboxylase Deficiency	3	14
Alkaptonuria	16	57
Hawkinsinuria	16	57
Tyrosinemia Type I	16	57
Disulfiram Action Pathway	23	66
Tyrosinemia, Transient, of the Newborn	16	57
Tyrosine Hydroxylase Deficiency	3	14
Dopamine beta-Hydroxylase Deficiency	16	57
Monoamine Oxidase-A Deficiency (MAO-A)	16	57
Ascorbate Metabolism	13	18
Xanthophyll Cycle	2	8
Ascorbate Biosynthesis	4	14
Tyrosine metabolism ( Tyrosine metabolism )	28	41
Folic acid network	0	70
Catecholamine synthesis	0	12
Ascorbate and aldarate metabolism	0	7
Cadmium and glutathione	1	13
AtMetExpress overview	0	109
Differentiation pathway	0	12
Selenium micronutrient network	0	95
Vitamin B12 metabolism	0	50
Effects of nitric oxide	0	7
Pluripotent stem cell differentiation pathway	0	11
Biochemical pathways: part I	0	466

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
acetylcholinesterase	Homo sapiens (human)	Potency	0.7762	0.0025	41.7960	15,848.9004	AID1347398
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	19.4699	0.0060	38.0041	19,952.5996	AID1159521
GLI family zinc finger 3	Homo sapiens (human)	Potency	8.0319	0.0007	14.5928	83.7951	AID1259369
AR protein	Homo sapiens (human)	Potency	9.5195	0.0002	21.2231	8,912.5098	AID743035; AID743063
thioredoxin glutathione reductase	Schistosoma mansoni	Potency	22.3872	0.1000	22.9075	100.0000	AID485364
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	23.9185	0.0123	7.9835	43.2770	AID1645841
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	8.9399	0.0002	14.3764	60.0339	AID720691; AID720692
retinoic acid nuclear receptor alpha variant 1	Homo sapiens (human)	Potency	42.4737	0.0030	41.6115	22,387.1992	AID1159552; AID1159555
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	24.3365	0.0015	30.6073	15,848.9004	AID1224841
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	28.2140	0.0002	29.3054	16,493.5996	AID743069; AID743075; AID743079; AID743080
vitamin D (1,25- dihydroxyvitamin D3) receptor	Homo sapiens (human)	Potency	0.0020	0.0237	23.2282	63.5986	AID588543
IDH1	Homo sapiens (human)	Potency	5.1735	0.0052	10.8652	35.4813	AID686970
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	12.5893	0.0355	20.9770	89.1251	AID504332
chromobox protein homolog 1	Homo sapiens (human)	Potency	100.0000	0.0060	26.1688	89.1251	AID540317
nuclear factor erythroid 2-related factor 2 isoform 2	Homo sapiens (human)	Potency	20.5962	0.0041	9.9848	25.9290	AID504444
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	28.9240	0.0003	23.4451	159.6830	AID743067
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	36.8721	0.0006	27.2152	1,122.0200	AID651741; AID743202; AID743219
lethal(3)malignant brain tumor-like protein 1 isoform I	Homo sapiens (human)	Potency	0.6310	0.0752	15.2253	39.8107	AID485360
geminin	Homo sapiens (human)	Potency	0.1836	0.0046	11.3741	33.4983	AID624297
lethal factor (plasmid)	Bacillus anthracis str. A2012	Potency	2.5119	0.0200	10.7869	31.6228	AID912
lamin isoform A-delta10	Homo sapiens (human)	Potency	0.0025	0.8913	12.0676	28.1838	AID1487
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	Potency	1.7783	0.0096	10.5250	35.4813	AID1479145
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, Hyaluronidase, phage associated	Streptococcus pyogenes	IC50 (µMol)	1,000.0000	1,000.0000	1,000.0000	1,000.0000	AID977608
Polyphenol oxidase 2	Agaricus bisporus	IC50 (µMol)	264.2500	0.0340	3.9871	10.0000	AID1505136; AID1555220; AID1610412; AID687640
Pancreatic alpha-amylase	Rattus norvegicus (Norway rat)	IC50 (µMol)	26.5000	0.0460	0.0460	0.0460	AID36971
Albumin	Bos taurus (cattle)	IC50 (µMol)	155.3800	3.0000	3.0000	3.0000	AID1497073
Urease	Canavalia ensiformis (jack bean)	IC50 (µMol)	8.5900	0.4570	3.2023	8.5900	AID1882616
Tyrosinase	Homo sapiens (human)	IC50 (µMol)	32.5000	0.0230	4.4593	10.0000	AID1193294
Solute carrier family 23 member 1	Homo sapiens (human)	IC50 (µMol)	156.0000	156.0000	156.0000	156.0000	AID1794810
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Alpha-2B adrenergic receptor	Homo sapiens (human)	EC50 (µMol)	0.0005	0.0005	1.3644	6.7100	AID416324
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Egl nine homolog 1	Homo sapiens (human)	Km	180.0000	2.0000	2.0000	2.0000	AID506732
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
cellular response to starvation	Albumin	Bos taurus (cattle)
negative regulation of mitochondrial depolarization	Albumin	Bos taurus (cattle)
cellular response to calcium ion starvation	Albumin	Bos taurus (cattle)
collagen fibril organization	Prolyl 4-hydroxylase subunit alpha-1	Homo sapiens (human)
peptidyl-proline hydroxylation to 4-hydroxy-L-proline	Prolyl 4-hydroxylase subunit alpha-1	Homo sapiens (human)
melanin biosynthetic process from tyrosine	Tyrosinase	Homo sapiens (human)
eye pigment biosynthetic process	Tyrosinase	Homo sapiens (human)
visual perception	Tyrosinase	Homo sapiens (human)
cell population proliferation	Tyrosinase	Homo sapiens (human)
response to UV	Tyrosinase	Homo sapiens (human)
response to blue light	Tyrosinase	Homo sapiens (human)
response to vitamin D	Tyrosinase	Homo sapiens (human)
melanin biosynthetic process	Tyrosinase	Homo sapiens (human)
thymus development	Tyrosinase	Homo sapiens (human)
response to cAMP	Tyrosinase	Homo sapiens (human)
pigmentation	Tyrosinase	Homo sapiens (human)
MAPK cascade	Alpha-2B adrenergic receptor	Homo sapiens (human)
angiogenesis	Alpha-2B adrenergic receptor	Homo sapiens (human)
regulation of vascular associated smooth muscle contraction	Alpha-2B adrenergic receptor	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Alpha-2B adrenergic receptor	Homo sapiens (human)
cell-cell signaling	Alpha-2B adrenergic receptor	Homo sapiens (human)
female pregnancy	Alpha-2B adrenergic receptor	Homo sapiens (human)
negative regulation of norepinephrine secretion	Alpha-2B adrenergic receptor	Homo sapiens (human)
platelet activation	Alpha-2B adrenergic receptor	Homo sapiens (human)
activation of protein kinase B activity	Alpha-2B adrenergic receptor	Homo sapiens (human)
negative regulation of epinephrine secretion	Alpha-2B adrenergic receptor	Homo sapiens (human)
receptor transactivation	Alpha-2B adrenergic receptor	Homo sapiens (human)
positive regulation of MAPK cascade	Alpha-2B adrenergic receptor	Homo sapiens (human)
positive regulation of neuron differentiation	Alpha-2B adrenergic receptor	Homo sapiens (human)
positive regulation of blood pressure	Alpha-2B adrenergic receptor	Homo sapiens (human)
positive regulation of uterine smooth muscle contraction	Alpha-2B adrenergic receptor	Homo sapiens (human)
adrenergic receptor signaling pathway	Alpha-2B adrenergic receptor	Homo sapiens (human)
adenylate cyclase-activating adrenergic receptor signaling pathway	Alpha-2B adrenergic receptor	Homo sapiens (human)
regulation of cell growth	Prolyl hydroxylase EGLN2	Homo sapiens (human)
response to hypoxia	Prolyl hydroxylase EGLN2	Homo sapiens (human)
peptidyl-proline hydroxylation to 4-hydroxy-L-proline	Prolyl hydroxylase EGLN2	Homo sapiens (human)
intracellular estrogen receptor signaling pathway	Prolyl hydroxylase EGLN2	Homo sapiens (human)
regulation of neuron apoptotic process	Prolyl hydroxylase EGLN2	Homo sapiens (human)
cell redox homeostasis	Prolyl hydroxylase EGLN2	Homo sapiens (human)
positive regulation of protein catabolic process	Prolyl hydroxylase EGLN2	Homo sapiens (human)
cellular response to hypoxia	Prolyl hydroxylase EGLN2	Homo sapiens (human)
response to hypoxia	Egl nine homolog 1	Homo sapiens (human)
intracellular iron ion homeostasis	Egl nine homolog 1	Homo sapiens (human)
intracellular oxygen homeostasis	Egl nine homolog 1	Homo sapiens (human)
negative regulation of DNA-binding transcription factor activity	Egl nine homolog 1	Homo sapiens (human)
regulation of angiogenesis	Egl nine homolog 1	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Egl nine homolog 1	Homo sapiens (human)
negative regulation of cyclic-nucleotide phosphodiesterase activity	Egl nine homolog 1	Homo sapiens (human)
cardiac muscle tissue morphogenesis	Egl nine homolog 1	Homo sapiens (human)
heart trabecula formation	Egl nine homolog 1	Homo sapiens (human)
ventricular septum morphogenesis	Egl nine homolog 1	Homo sapiens (human)
labyrinthine layer development	Egl nine homolog 1	Homo sapiens (human)
response to nitric oxide	Egl nine homolog 1	Homo sapiens (human)
regulation of modification of postsynaptic structure	Egl nine homolog 1	Homo sapiens (human)
regulation protein catabolic process at postsynapse	Egl nine homolog 1	Homo sapiens (human)
peptidyl-proline hydroxylation to 4-hydroxy-L-proline	Egl nine homolog 1	Homo sapiens (human)
cellular response to hypoxia	Egl nine homolog 1	Homo sapiens (human)
response to hypoxia	Prolyl hydroxylase EGLN3	Homo sapiens (human)
apoptotic process	Prolyl hydroxylase EGLN3	Homo sapiens (human)
activation of cysteine-type endopeptidase activity involved in apoptotic process	Prolyl hydroxylase EGLN3	Homo sapiens (human)
DNA damage response	Prolyl hydroxylase EGLN3	Homo sapiens (human)
protein hydroxylation	Prolyl hydroxylase EGLN3	Homo sapiens (human)
regulation of cell population proliferation	Prolyl hydroxylase EGLN3	Homo sapiens (human)
regulation of neuron apoptotic process	Prolyl hydroxylase EGLN3	Homo sapiens (human)
cellular response to hypoxia	Prolyl hydroxylase EGLN3	Homo sapiens (human)
peptidyl-proline hydroxylation to 4-hydroxy-L-proline	Prolyl hydroxylase EGLN3	Homo sapiens (human)
positive regulation of myoblast differentiation	Hypoxia-inducible factor 1-alpha inhibitor	Homo sapiens (human)
negative regulation of Notch signaling pathway	Hypoxia-inducible factor 1-alpha inhibitor	Homo sapiens (human)
negative regulation of DNA-templated transcription	Hypoxia-inducible factor 1-alpha inhibitor	Homo sapiens (human)
positive regulation of vasculogenesis	Hypoxia-inducible factor 1-alpha inhibitor	Homo sapiens (human)
sodium ion transport	Solute carrier family 23 member 1	Homo sapiens (human)
brain development	Solute carrier family 23 member 1	Homo sapiens (human)
response to toxic substance	Solute carrier family 23 member 1	Homo sapiens (human)
urate transport	Solute carrier family 23 member 1	Homo sapiens (human)
nucleobase transport	Solute carrier family 23 member 1	Homo sapiens (human)
L-ascorbic acid transmembrane transport	Solute carrier family 23 member 1	Homo sapiens (human)
L-ascorbic acid metabolic process	Solute carrier family 23 member 1	Homo sapiens (human)
lung development	Solute carrier family 23 member 1	Homo sapiens (human)
sodium ion transmembrane transport	Solute carrier family 23 member 1	Homo sapiens (human)
dehydroascorbic acid transport	Solute carrier family 23 member 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
oxygen binding	Albumin	Bos taurus (cattle)
DNA binding	Albumin	Bos taurus (cattle)
fatty acid binding	Albumin	Bos taurus (cattle)
protein binding	Albumin	Bos taurus (cattle)
toxic substance binding	Albumin	Bos taurus (cattle)
pyridoxal phosphate binding	Albumin	Bos taurus (cattle)
metal ion binding	Albumin	Bos taurus (cattle)
enterobactin binding	Albumin	Bos taurus (cattle)
procollagen-proline 4-dioxygenase activity	Prolyl 4-hydroxylase subunit alpha-1	Homo sapiens (human)
iron ion binding	Prolyl 4-hydroxylase subunit alpha-1	Homo sapiens (human)
protein binding	Prolyl 4-hydroxylase subunit alpha-1	Homo sapiens (human)
L-ascorbic acid binding	Prolyl 4-hydroxylase subunit alpha-1	Homo sapiens (human)
identical protein binding	Prolyl 4-hydroxylase subunit alpha-1	Homo sapiens (human)
tyrosinase activity	Tyrosinase	Homo sapiens (human)
copper ion binding	Tyrosinase	Homo sapiens (human)
protein binding	Tyrosinase	Homo sapiens (human)
identical protein binding	Tyrosinase	Homo sapiens (human)
protein homodimerization activity	Tyrosinase	Homo sapiens (human)
alpha2-adrenergic receptor activity	Alpha-2B adrenergic receptor	Homo sapiens (human)
protein binding	Alpha-2B adrenergic receptor	Homo sapiens (human)
epinephrine binding	Alpha-2B adrenergic receptor	Homo sapiens (human)
protein binding	Prolyl hydroxylase EGLN2	Homo sapiens (human)
ferrous iron binding	Prolyl hydroxylase EGLN2	Homo sapiens (human)
2-oxoglutarate-dependent dioxygenase activity	Prolyl hydroxylase EGLN2	Homo sapiens (human)
oxygen sensor activity	Prolyl hydroxylase EGLN2	Homo sapiens (human)
L-ascorbic acid binding	Prolyl hydroxylase EGLN2	Homo sapiens (human)
peptidyl-proline 4-dioxygenase activity	Prolyl hydroxylase EGLN2	Homo sapiens (human)
hypoxia-inducible factor-proline dioxygenase activity	Prolyl hydroxylase EGLN2	Homo sapiens (human)
protein binding	Egl nine homolog 1	Homo sapiens (human)
ferrous iron binding	Egl nine homolog 1	Homo sapiens (human)
2-oxoglutarate-dependent dioxygenase activity	Egl nine homolog 1	Homo sapiens (human)
enzyme binding	Egl nine homolog 1	Homo sapiens (human)
L-ascorbic acid binding	Egl nine homolog 1	Homo sapiens (human)
peptidyl-proline dioxygenase activity	Egl nine homolog 1	Homo sapiens (human)
hypoxia-inducible factor-proline dioxygenase activity	Egl nine homolog 1	Homo sapiens (human)
peptidyl-proline 4-dioxygenase activity	Egl nine homolog 1	Homo sapiens (human)
protein binding	Prolyl hydroxylase EGLN3	Homo sapiens (human)
2-oxoglutarate-dependent dioxygenase activity	Prolyl hydroxylase EGLN3	Homo sapiens (human)
L-ascorbic acid binding	Prolyl hydroxylase EGLN3	Homo sapiens (human)
peptidyl-proline 4-dioxygenase activity	Prolyl hydroxylase EGLN3	Homo sapiens (human)
hypoxia-inducible factor-proline dioxygenase activity	Prolyl hydroxylase EGLN3	Homo sapiens (human)
ferrous iron binding	Prolyl hydroxylase EGLN3	Homo sapiens (human)
transcription corepressor activity	Hypoxia-inducible factor 1-alpha inhibitor	Homo sapiens (human)
Notch binding	Hypoxia-inducible factor 1-alpha inhibitor	Homo sapiens (human)
protein binding	Hypoxia-inducible factor 1-alpha inhibitor	Homo sapiens (human)
ferrous iron binding	Hypoxia-inducible factor 1-alpha inhibitor	Homo sapiens (human)
zinc ion binding	Hypoxia-inducible factor 1-alpha inhibitor	Homo sapiens (human)
oxygen sensor activity	Hypoxia-inducible factor 1-alpha inhibitor	Homo sapiens (human)
carboxylic acid binding	Hypoxia-inducible factor 1-alpha inhibitor	Homo sapiens (human)
peptidyl-histidine dioxygenase activity	Hypoxia-inducible factor 1-alpha inhibitor	Homo sapiens (human)
[protein]-asparagine 3-dioxygenase activity	Hypoxia-inducible factor 1-alpha inhibitor	Homo sapiens (human)
protein homodimerization activity	Hypoxia-inducible factor 1-alpha inhibitor	Homo sapiens (human)
NF-kappaB binding	Hypoxia-inducible factor 1-alpha inhibitor	Homo sapiens (human)
peptidyl-aspartic acid 3-dioxygenase activity	Hypoxia-inducible factor 1-alpha inhibitor	Homo sapiens (human)
ankyrin repeat binding	Hypoxia-inducible factor 1-alpha inhibitor	Homo sapiens (human)
protein binding	Solute carrier family 23 member 1	Homo sapiens (human)
L-ascorbate:sodium symporter activity	Solute carrier family 23 member 1	Homo sapiens (human)
sodium ion transmembrane transporter activity	Solute carrier family 23 member 1	Homo sapiens (human)
urate transmembrane transporter activity	Solute carrier family 23 member 1	Homo sapiens (human)
nucleobase transmembrane transporter activity	Solute carrier family 23 member 1	Homo sapiens (human)
L-ascorbic acid transmembrane transporter activity	Solute carrier family 23 member 1	Homo sapiens (human)
dehydroascorbic acid transmembrane transporter activity	Solute carrier family 23 member 1	Homo sapiens (human)
transporter activity	Solute carrier family 23 member 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
extracellular region	Albumin	Bos taurus (cattle)
extracellular space	Albumin	Bos taurus (cattle)
protein-containing complex	Albumin	Bos taurus (cattle)
mitochondrion	Prolyl 4-hydroxylase subunit alpha-1	Homo sapiens (human)
endoplasmic reticulum	Prolyl 4-hydroxylase subunit alpha-1	Homo sapiens (human)
endoplasmic reticulum lumen	Prolyl 4-hydroxylase subunit alpha-1	Homo sapiens (human)
membrane	Prolyl 4-hydroxylase subunit alpha-1	Homo sapiens (human)
intracellular membrane-bounded organelle	Prolyl 4-hydroxylase subunit alpha-1	Homo sapiens (human)
procollagen-proline 4-dioxygenase complex	Prolyl 4-hydroxylase subunit alpha-1	Homo sapiens (human)
endoplasmic reticulum	Prolyl 4-hydroxylase subunit alpha-1	Homo sapiens (human)
cytoplasm	Tyrosinase	Homo sapiens (human)
lysosome	Tyrosinase	Homo sapiens (human)
Golgi-associated vesicle	Tyrosinase	Homo sapiens (human)
melanosome membrane	Tyrosinase	Homo sapiens (human)
melanosome	Tyrosinase	Homo sapiens (human)
intracellular membrane-bounded organelle	Tyrosinase	Homo sapiens (human)
perinuclear region of cytoplasm	Tyrosinase	Homo sapiens (human)
cytosol	Alpha-2B adrenergic receptor	Homo sapiens (human)
plasma membrane	Alpha-2B adrenergic receptor	Homo sapiens (human)
cell surface	Alpha-2B adrenergic receptor	Homo sapiens (human)
intracellular membrane-bounded organelle	Alpha-2B adrenergic receptor	Homo sapiens (human)
plasma membrane	Alpha-2B adrenergic receptor	Homo sapiens (human)
virion membrane	Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus
nucleus	Prolyl hydroxylase EGLN2	Homo sapiens (human)
nucleoplasm	Prolyl hydroxylase EGLN2	Homo sapiens (human)
nucleus	Prolyl hydroxylase EGLN2	Homo sapiens (human)
cytoplasm	Prolyl hydroxylase EGLN2	Homo sapiens (human)
cytoplasm	Egl nine homolog 1	Homo sapiens (human)
cytosol	Egl nine homolog 1	Homo sapiens (human)
postsynaptic density	Egl nine homolog 1	Homo sapiens (human)
intracellular membrane-bounded organelle	Egl nine homolog 1	Homo sapiens (human)
glutamatergic synapse	Egl nine homolog 1	Homo sapiens (human)
nucleus	Egl nine homolog 1	Homo sapiens (human)
cytoplasm	Egl nine homolog 1	Homo sapiens (human)
nucleus	Prolyl hydroxylase EGLN3	Homo sapiens (human)
nucleoplasm	Prolyl hydroxylase EGLN3	Homo sapiens (human)
cytoplasm	Prolyl hydroxylase EGLN3	Homo sapiens (human)
cytosol	Prolyl hydroxylase EGLN3	Homo sapiens (human)
cytoplasm	Prolyl hydroxylase EGLN3	Homo sapiens (human)
nucleus	Prolyl hydroxylase EGLN3	Homo sapiens (human)
nucleus	Hypoxia-inducible factor 1-alpha inhibitor	Homo sapiens (human)
nucleoplasm	Hypoxia-inducible factor 1-alpha inhibitor	Homo sapiens (human)
cytoplasm	Hypoxia-inducible factor 1-alpha inhibitor	Homo sapiens (human)
cytosol	Hypoxia-inducible factor 1-alpha inhibitor	Homo sapiens (human)
perinuclear region of cytoplasm	Hypoxia-inducible factor 1-alpha inhibitor	Homo sapiens (human)
cytoplasm	Hypoxia-inducible factor 1-alpha inhibitor	Homo sapiens (human)
cytoplasm	Solute carrier family 23 member 1	Homo sapiens (human)
plasma membrane	Solute carrier family 23 member 1	Homo sapiens (human)
basal plasma membrane	Solute carrier family 23 member 1	Homo sapiens (human)
apical plasma membrane	Solute carrier family 23 member 1	Homo sapiens (human)
intracellular organelle	Solute carrier family 23 member 1	Homo sapiens (human)
extracellular exosome	Solute carrier family 23 member 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (1029)

Assay ID	Title	Year	Journal	Article
AID504749	qHTS profiling for inhibitors of Plasmodium falciparum proliferation	2011	Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043	Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
AID1347090	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347096	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347425	Rhodamine-PBP qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1)	2019	The Journal of biological chemistry, 11-15, Volume: 294, Issue:46	Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
AID1508630	Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay	2021	Cell reports, 04-27, Volume: 35, Issue:4	A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347099	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1296008	Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening	2020	SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1	Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347102	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347086	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347091	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347105	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347107	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347407	qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Pharmaceutical Collection	2020	ACS chemical biology, 07-17, Volume: 15, Issue:7	High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1347083	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1347101	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347100	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347424	RapidFire Mass Spectrometry qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1)	2019	The Journal of biological chemistry, 11-15, Volume: 294, Issue:46	Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
AID1347094	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347082	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347104	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID1347154	Primary screen GU AMC qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347093	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347098	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347106	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347097	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347089	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347108	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347092	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347095	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347103	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1345074	Human Sodium-dependent vitamin C transporter 1 (SLC23 family of ascorbic acid transporters)	2002	The British journal of nutrition, Feb, Volume: 87, Issue:2	Decreased expression of the vitamin C transporter SVCT1 by ascorbic acid in a human intestinal epithelial cell line.
AID1346987	P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346986	P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID173159	Antilipid peroxidation was determined	1988	Journal of medicinal chemistry, Apr, Volume: 31, Issue:4	Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID1896735	Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins under dark condition by microplate reader based assay	2022	Bioorganic & medicinal chemistry, Nov-05, Volume: 75	Phenolic furanochromene hydrazone derivatives: Synthesis, antioxidant activity, ferroptosis inhibition, DNA cleavage and DNA molecular docking studies.
AID401061	Antioxidant activity assessed as DPPH free radical scavenging activity	1998	Journal of natural products, May, Volume: 61, Issue:5	Antioxidant flavonoid glycosides from Daphniphyllum calycinum.
AID104665	Inhibition of malt alpha-amylase	1998	Bioorganic & medicinal chemistry letters, Jul-07, Volume: 8, Issue:13	Ascorbic acid-based inhibitors of alpha-amylases.
AID463457	Antioxidant activity against DPPH radical scavenging activity after 30 mins by ELISA	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	New pyrazoles incorporating pyrazolylpyrazole moiety: synthesis, anti-HCV and antitumor activity.
AID1071362	Antioxidant activity assessed as DPPH free radical scavenging activity at 500 uM after 30 mins by spectrophotometry	2014	European journal of medicinal chemistry, Feb-12, Volume: 73	Synthesis and antiproliferative activity of novel selenoester derivatives.
AID652726	Antiviral activity against Herpes simplex virus type 1 infected in human RD cells assessed as inhibition of virus-induced cytopathic effect	2012	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7	Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
AID1331320	Antioxidant activity assessed as DPPH radical scavenging activity at 10 uM	2017	Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2	Synthesis and application of β-carbolines as novel multi-functional anti-Alzheimer's disease agents.
AID1194982	Antioxidant activity assessed as ABTS radical scavenging activity after 15 mins	2015	Bioorganic & medicinal chemistry letters, , Volume: 25, Issue:10	Cytotoxic and antioxidant constituents from the leaves of Psidium guajava.
AID389191	Antioxidant activity assessed as oxygen radical absorbance capacity index value at 5 uM by pyrogallol red protection assay	2008	Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20	Antioxidant capacity of human blood plasma and human urine: simultaneous evaluation of the ORAC index and ascorbic acid concentration employing pyrogallol red as probe.
AID718314	Antioxidant activity assessed as nitric oxide free radical scavenging activity by UV-visible spectroscopy	2012	Journal of natural products, Dec-28, Volume: 75, Issue:12	Phenolic compounds from Caesalpinia sappan heartwood and their anti-inflammatory activity.
AID356320	Antioxidant activity assessed as DPPH radical scavenging activity	2003	Journal of natural products, Aug, Volume: 66, Issue:8	Sulfemodin 8-O-beta-D-glucoside, a new sulfated anthraquinone glycoside, and antioxidant phenolic compounds from Rheum emodi.
AID771137	Antioxidant activity assessed as DPPH radical scavenging activity incubated for 20 mins under dark condition by spectrophotometric analysis	2013	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 23, Issue:19	Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs).
AID724078	Antioxidant activity assessed as superoxide radical scavenging activity at 100 uM after 5 mins by NBT reduction assay	2013	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 23, Issue:3	Design, synthesis, characterization and biological evaluation of novel pyrazole integrated benzophenones.
AID405697	Antioxidant activity assessed as oxygen radical scavenging activity by ORAC-fluorescence assay	2008	Journal of natural products, Jun, Volume: 71, Issue:6	Antioxidant 2-phenylbenzofurans and a coumestan from Lespedeza virgata.
AID685399	Antioxidant activity assessed as inhibition of superoxide radical-induced NBT reduction by alkaline DMSO method	2012	European journal of medicinal chemistry, Oct, Volume: 56	Docking studies, synthesis, characterization of some novel oxazine substituted 9-anilinoacridine derivatives and evaluation for their antioxidant and anticancer activities as topoisomerase II inhibitors.
AID722717	Antioxidant activity assessed as inhibition DPPH radical production after 15 mins by spectrophotometric analysis	2013	Bioorganic & medicinal chemistry, Jan-01, Volume: 21, Issue:1	Trisubstituted thiophene analogues of 1-thiazolyl-2-pyrazoline, super oxidase inhibitors and free radical scavengers.
AID652745	Antioxidant activity using deaerated 0.1 M alpha-glycerophosphate as substrate assessed as inorganic phosphate level at 1 mmol/L after gamma-irradiation (Rvb = 3.44 +/- 0.12 10'7 mol/J)	2012	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7	Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
AID619976	Antioxidant activity assessed as nitric oxide scavenging activity at 50 ug/ml after 150 mins by Griess method relative to control	2011	European journal of medicinal chemistry, Oct, Volume: 46, Issue:10	Synthesis and antioxidant activity of oxazolyl/thiazolylsulfonylmethyl pyrazoles and isoxazoles.
AID1635489	Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 80 uM after 24 hrs by MTT assay	2016	Journal of medicinal chemistry, 06-23, Volume: 59, Issue:12	Benzylpiperidine-Linked Diarylthiazoles as Potential Anti-Alzheimer's Agents: Synthesis and Biological Evaluation.
AID1549507	Haemolytic activity in human erythrocytes assessed as induction of hemolysis at 2.5 mM after 30 mins relative to H202	2019	European journal of medicinal chemistry, May-01, Volume: 169	Anticancer activity, dual prooxidant/antioxidant effect and apoptosis induction profile of new bichalcophene-5-carboxamidines.
AID294912	Antioxidant activity assessed as nitric oxide radical scavenging activity at 0.1 ug/ml after 150 mins	2007	European journal of medicinal chemistry, Aug, Volume: 42, Issue:8	Syntheses of new tetrasubstituted thiophenes as novel anti-inflammatory agents.
AID1309174	Ratio of resveratrol IC50 to compound IC50 for AAPH radical scavenging activity	2016	Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16	Ionophoric polyphenols selectively bind Cu(2+), display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila.
AID1301297	Antioxidant activity assessed as ABTS radical scavenging activity after 60 mins	2016	Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13	Enantioselective synthesis and antioxidant activity of 3,4,5-substituted piperidine derivatives.
AID614053	Inhibition of bovine testes hyaluronidase at 4200 uM after 30 mins at pH 5 by turbidimetric analysis	2011	European journal of medicinal chemistry, Sep, Volume: 46, Issue:9	Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase.
AID754975	Inhibition of N-terminal His6-tagged human reticulocyte 15-LOX1 pseudoperoxidase activity assessed as reduction of active ferric ion to inactive ferrous state measured decomposition of 13-(S)-HPODE at 40 uM after 30 mins by iron-xylenol orange staining as	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Pseudoperoxidase investigations of hydroperoxides and inhibitors with human lipoxygenases.
AID1439751	Antioxidant activity assessed as inhibition of superoxide radical generation at 1 mM after 5 mins by NBT reduction assay relative to control	2017	Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7	Synthesis of extended conjugated indolyl chalcones as potent anti-breast cancer, anti-inflammatory and antioxidant agents.
AID1487135	Antioxidant activity assessed as DPPH free radical scavenging activity measured after 30 mins in absence of light	2017	Bioorganic & medicinal chemistry, 08-15, Volume: 25, Issue:16	Phenylsulfonylfuroxan NO-donor phenols: Synthesis and multifunctional activities evaluation.
AID1071363	Antioxidant activity assessed as DPPH free radical scavenging activity at 150 uM after 30 mins by spectrophotometry	2014	European journal of medicinal chemistry, Feb-12, Volume: 73	Synthesis and antiproliferative activity of novel selenoester derivatives.
AID1352202	Antioxidant activity in PBS buffer assessed as NO scavenging activity after 90 mins in presence of sodium nitroprusside by Griess assay	2018	European journal of medicinal chemistry, Feb-10, Volume: 145	Design, synthesis, biological evaluation and docking studies of new 3-(4,5-dihydro-1H-pyrazol/isoxazol-5-yl)-2-phenyl-1H-indole derivatives as potent antioxidants and 15-lipoxygenase inhibitors.
AID1265669	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by plate reader analysis	2015	Journal of natural products, Nov-25, Volume: 78, Issue:11	Indoline Amide Glucosides from Portulaca oleracea: Isolation, Structure, and DPPH Radical Scavenging Activity.
AID549278	Inhibition of DOPA oxidase activity of tyrosinase in mouse B16 cells at 10 to 20 ug/ml after 72 hrs by colorimetry	2010	Journal of natural products, Nov-29, Volume: 73, Issue:11	Inhibition of melanogenesis and oxidation by protocatechuic acid from Origanum vulgare (oregano).
AID1896736	Antioxidant activity assessed as trolox equivalent of Cu2+ reducing activity incubated for 30 mins by CUPRAC assay relative to trolox	2022	Bioorganic & medicinal chemistry, Nov-05, Volume: 75	Phenolic furanochromene hydrazone derivatives: Synthesis, antioxidant activity, ferroptosis inhibition, DNA cleavage and DNA molecular docking studies.
AID294917	Antioxidant activity assessed as nitric oxide radical scavenging activity at 1.0 ug/ml after 150 mins	2007	European journal of medicinal chemistry, Aug, Volume: 42, Issue:8	Syntheses of new tetrasubstituted thiophenes as novel anti-inflammatory agents.
AID1466640	Antioxidant activity assessed as inhibition of DPPH free radical at 125 uM after 30 mins relative to control	2017	Bioorganic & medicinal chemistry, 07-01, Volume: 25, Issue:13	Antioxidant and anticholinesterase potential of diterpenoid alkaloids from Aconitum heterophyllum.
AID1610482	Inhibition of equine serum BuChE at 20 uM using butyrylcholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method relative to control	2019	Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23	Synthesis of 2-arylhydrazinylidene-3-oxo-4,4,4-trifluorobutanoic acids as new selective carboxylesterase inhibitors and radical scavengers.
AID457086	Antioxidant activity assessed as superoxide radical scavenging activity after 2 mins by NBT reduction assay	2010	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3	Natural ortho-dihydroxyisoflavone derivatives from aged Korean fermented soybean paste as potent tyrosinase and melanin formation inhibitors.
AID721640	Antioxidant activity assessed as trolox equivalent of DPPH radical scavenging activity by spectroscopic analysis	2013	European journal of medicinal chemistry, Feb, Volume: 60	Monocyclic β-lactams as antibacterial agents: facing antioxidant activity of N-methylthio-azetidinones.
AID1867444	Induction of ROS generation in fluconazole resistant Saccharomyces cerevisiae overexpressing CgCdr2p transporter assessed as increase in ROS level incubated for 90 mins by DCFH-DA dye based fluorescence assay	2022	Bioorganic & medicinal chemistry, 06-01, Volume: 63	Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID289708	Nitric oxide radical scavenging activity at 0.1 mg/ml	2007	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 17, Issue:3	Natural dibenzoxazepinones from leaves of Carex distachya: Structural elucidation and radical scavenging activity.
AID619974	Antioxidant activity assessed as DPPH free radical scavenging activity at 100 ug/ml after 30 mins by spectrophotometric analysis relative to control	2011	European journal of medicinal chemistry, Oct, Volume: 46, Issue:10	Synthesis and antioxidant activity of oxazolyl/thiazolylsulfonylmethyl pyrazoles and isoxazoles.
AID1071365	Antioxidant activity assessed as DPPH free radical scavenging activity at 15 uM after 30 mins by spectrophotometry	2014	European journal of medicinal chemistry, Feb-12, Volume: 73	Synthesis and antiproliferative activity of novel selenoester derivatives.
AID977602	Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM	2013	Molecular pharmacology, Jun, Volume: 83, Issue:6	Structure-based identification of OATP1B1/3 inhibitors.
AID1730957	Antioxidant activity assessed as DPPH radical scavenging activity at 25 ug/ml (Rvb = 22 to 40.2 %)	2021	Bioorganic & medicinal chemistry letters, 03-15, Volume: 36	Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme.
AID1487136	Antioxidant activity assessed as H2O2 radical scavenging activity after 60 mins	2017	Bioorganic & medicinal chemistry, 08-15, Volume: 25, Issue:16	Phenylsulfonylfuroxan NO-donor phenols: Synthesis and multifunctional activities evaluation.
AID1113090	Antioxidant activity assessed as superoxide anion radical scavenging activity at 5 mg/ml after 5 min by spectrophotometric analysis	2013	Journal of agricultural and food chemistry, Mar-27, Volume: 61, Issue:12	Isolation and characterization of new p-Terphenyls with antifungal, antibacterial, and antioxidant activities from halophilic actinomycete Nocardiopsis gilva YIM 90087.
AID619972	Antioxidant activity assessed as DPPH free radical scavenging activity at 50 ug/ml after 30 mins by spectrophotometric analysis relative to control	2011	European journal of medicinal chemistry, Oct, Volume: 46, Issue:10	Synthesis and antioxidant activity of oxazolyl/thiazolylsulfonylmethyl pyrazoles and isoxazoles.
AID476929	Human intestinal absorption in po dosed human	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
AID762742	Antioxidant activity assessed as DPPH free radical scavenging activity at 10 ug/ml after 20 mins	2013	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 23, Issue:16	Novel pyrazoline amidoxime and their 1,2,4-oxadiazole analogues: synthesis and pharmacological screening.
AID504290	Antioxidant activity assessed as superoxide radical scavenging activity by NBT method	2010	Journal of natural products, Sep-24, Volume: 73, Issue:9	Chlorinated iridoid glucosides from Veronica longifolia and their antioxidant activity.
AID283697	DPPH radical scavenging activity at 200 umol/L relative to control	2007	Journal of natural products, Apr, Volume: 70, Issue:4	Bioactive metabolites from the Caribbean sponge Aka coralliphagum.
AID1556931	Prooxidant activity in calf thymus DNA assessed as increase in bleomycin-induced DNA damage by measuring optical density at 2 mM incubated for 1 hr by spectrophotometry relative to control	2019	European journal of medicinal chemistry, Oct-01, Volume: 179	Synthesis and biochemical studies of novel organic selenides with increased selectivity for hepatocellular carcinoma and breast adenocarcinoma.
AID724079	Antioxidant activity of the compound assessed as DPPH radical scavenging activity at 100 uM after 20 mins	2013	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 23, Issue:3	Design, synthesis, characterization and biological evaluation of novel pyrazole integrated benzophenones.
AID652906	Antioxidant activity using deaerated 0.1 M alpha-glucosophosphate as substrate assessed as hydroxy radical level at 1 mmol/L after gamma-irradiation	2012	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7	Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
AID1565350	Antioxidant activity assessed as DPPH radical scavenging activity at 60 uM/ml incubated for 20 mins by spectrophotometric method relative to control	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Cyclic enaminone as new chemotype for selective cyclooxygenase-2 inhibitory, anti-inflammatory, and analgesic activities.
AID762737	Antioxidant activity assessed as reducing power of ferric ion at 50 ug/ml after 20 mins	2013	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 23, Issue:16	Novel pyrazoline amidoxime and their 1,2,4-oxadiazole analogues: synthesis and pharmacological screening.
AID1071366	Antioxidant activity assessed as DPPH free radical scavenging activity at 5 uM after 30 mins by spectrophotometry	2014	European journal of medicinal chemistry, Feb-12, Volume: 73	Synthesis and antiproliferative activity of novel selenoester derivatives.
AID764769	Antioxidant activity assessed as DPPH radical scavenging activity at 10 uM after 30 mins	2013	Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17	Design, synthesis and pharmacological evaluation of (E)-3,4-dihydroxy styryl sulfonamides derivatives as multifunctional neuroprotective agents against oxidative and inflammatory injury.
AID590698	Antioxidant activity against DPPH free radical scavenging activity at 100 uM after 20 mins by spectrophotometric analysis at pH 7.5	2011	European journal of medicinal chemistry, Apr, Volume: 46, Issue:4	Synthesis and biological activity of 2-(bis((1,3,4-oxadiazolyl/1,3,4-thiadiazolyl)methylthio)methylene)malononitriles.
AID1651267	Antioxidant activity assessed as hydroxyl radical scavenging activity incubated for 30 mins in water bath	2020	Bioorganic & medicinal chemistry letters, 02-15, Volume: 30, Issue:4	Design, synthesis and anti-Alzheimer's disease activity study of xanthone derivatives based on multi-target strategy.
AID453102	Antioxidant activity assessed as DPPH free radical scavenging activity by measuring reduction in DPPH absorbance by ELISA relative to untreated control	2009	Bioorganic & medicinal chemistry, Dec-01, Volume: 17, Issue:23	Synthesis, tautomerism, and antimicrobial, anti-HCV, anti-SSPE, antioxidant, and antitumor activities of arylazobenzosuberones.
AID1453046	Antioxidant activity assessed as DPPH radical scavenging activity after 20 mins under dark condition by UV-Visible spectrophotometric analysis	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Synthesis, characterization, molecular docking and in vitro antimalarial properties of new carboxamides bearing sulphonamide.
AID515373	Antioxidant activity assessed as hydrogen peroxide scavenging activity by spectrophotometry	2010	Bioorganic & medicinal chemistry, Sep-15, Volume: 18, Issue:18	2,3-diarylxanthones as strong scavengers of reactive oxygen and nitrogen species: a structure-activity relationship study.
AID1753663	Antioxidant activity assessed as bleomycin-Fe2+-induced DNA degradation by measuring absorbance at 0.1 mg/ml after 1 hr	2021	European journal of medicinal chemistry, Jun-05, Volume: 218	New organoselenides (NSAIDs-Se derivatives) as potential anticancer agents: Synthesis, biological evaluation and in silico calculations.
AID226689	Free radical scavenging activity of DPPH was determined	2004	Bioorganic & medicinal chemistry letters, May-03, Volume: 14, Issue:9	Neuroprotective effects of flavones on hydrogen peroxide-induced apoptosis in SH-SY5Y neuroblostoma cells.
AID1651261	Selectivity index, ratio of IC50 for equine serum BChE using butyrylthiocholine as substrate by Ellman's method to IC50 for electric eel AChE using acetylthiocholine as substrate by Ellman's method	2020	Bioorganic & medicinal chemistry letters, 02-15, Volume: 30, Issue:4	Design, synthesis and anti-Alzheimer's disease activity study of xanthone derivatives based on multi-target strategy.
AID1453461	Antioxidant activity of the compound in phosphate buffer at pH 6.6 assessed as potassium ferric cyanide ion reducing activity at 25 umol/ml after 20 mins by spectrophotometric method relative to control	2017	Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13	Synthesis of methanesulphonamido-benzimidazole derivatives as gastro-sparing antiinflammatory agents with antioxidant effect.
AID1255363	Antioxidant activity assessed as DPPH radical scavenging activity measured as discoloration incubated for 30 mins in dark	2015	European journal of medicinal chemistry, Oct-20, Volume: 103	Correlation of antioxidant activities with theoretical studies for new hydrazone compounds bearing a 3,4,5-trimethoxy benzyl moiety.
AID734220	Antioxidant activity assessed as concentration required for 50 % inhibition of micoM DPPH activity after 30 mins by UV-vis spectrophotometry	2013	Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7	Fungal metabolites of xanthohumol with potent antiproliferative activity on human cancer cell lines in vitro.
AID1178158	Antioxidant activity of the compound assessed as reduction in absorbance of DPPH after 60 mins incubation at 100 uM by DPPH radical scavenging /microplate assay	2014	Bioorganic & medicinal chemistry, May-01, Volume: 22, Issue:9	Synthesis, antioxidant and photoprotection activities of hybrid derivatives useful to prevent skin cancer.
AID1594664	Antioxidant activity assessed as DPPH radical scavenging activity at 1 mM after 30 mins under dark condition relative to untreated control	2019	Bioorganic & medicinal chemistry, 06-01, Volume: 27, Issue:11	Antioxidant, anti-tyrosinase and anti-melanogenic effects of (E)-2,3-diphenylacrylic acid derivatives.
AID761966	Hemolysis of human erythrocytes after 30 mins by spectrophotometry	2013	European journal of medicinal chemistry, Aug, Volume: 66	Novel 2-(2,4-dioxo-1,3-thiazolidin-5-yl)acetamides as antioxidant and/or anti-inflammatory compounds.
AID416324	Agonist activity at human adrenergic alpha2B receptor expressed in HEK293 cells coexpressing Gqi5 protein by FLIPR assay	2009	Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6	(-)-Dibromophakellin: an alpha2B adrenoceptor agonist isolated from the Australian marine sponge, Acanthella costata.
AID1322145	Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins incubation in dark	2016	Bioorganic & medicinal chemistry, 11-01, Volume: 24, Issue:21	Thioflavones as novel neuroprotective agents.
AID1347585	Upregulation of elastin mRNA expression in HDF at 100 uM after 48 hrs by RT-PCR analysis	2017	Journal of natural products, 11-22, Volume: 80, Issue:11	neo-Clerodane Diterpenoids from Salvia polystachya Stimulate the Expression of Extracellular Matrix Components in Human Dermal Fibroblasts.
AID1125421	Antioxidant activity assessed as potassium ferric cyanide ion reducing power after 20 mins by absorbance analysis	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Two sarcoviolins with antioxidative and α-glucosidase inhibitory activity from the edible mushroom Sarcodon leucopus collected in Tibet.
AID714928	Antioxidant activity assessed as superoxide scavenging activity using xanthine-xanthine oxidase system by NBT dye reduction based assay	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues.
AID615294	Antioxidant activity assessed as potassium ferricyanide ion reducing power after 20 mins by spectrophotometry	2011	European journal of medicinal chemistry, May, Volume: 46, Issue:5	Synthesis and bio-activity evaluation of tetraphenyl(phenylamino) methylene bisphosphonates as antioxidant agents and as potent inhibitors of osteoclasts in vitro.
AID614022	Inhibition of Streptococcus pneumoniae hyaluronidase after 1 hr by microplate reader assay	2011	European journal of medicinal chemistry, Sep, Volume: 46, Issue:9	Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase.
AID1202774	Antioxidant activity assessed as trolox equivalent of APPH radical scavenging activity preincubated for 30 mins followed by APPH addition measured after 90 mins by hydrophilic-ORAC fluorescence assay	2015	Journal of natural products, Feb-27, Volume: 78, Issue:2	Antioxidative compounds from Garcinia buchananii stem bark.
AID1399488	Antioxidant activity assessed as ABTS radical cation scavenging activity by measuring trolox equivalent antioxidant capacity at 20 uM after 1 hr by UV/Vis spectrophotometric analysis	2018	Bioorganic & medicinal chemistry, 09-01, Volume: 26, Issue:16	Synthesis, molecular docking, and biological activity of 2-vinyl chromones: Toward selective butyrylcholinesterase inhibitors for potential Alzheimer's disease therapeutics.
AID1272818	Antileishmanial activity against promastigotes of Leishmania donovani MHOM/IN/80/DD8 after 72 hrs by MTT assay	2016	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3	Antileishmanial activity of novel indolyl-coumarin hybrids: Design, synthesis, biological evaluation, molecular docking study and in silico ADME prediction.
AID1076256	Antioxidant activity assessed as H2O2 radical scavenging activity	2014	European journal of medicinal chemistry, Mar-21, Volume: 75	Synthesis, docking and evaluation of antioxidant and antimicrobial activities of novel 1,2,4-triazolo[3,4-b][1,3,4]thiadiazol-6-yl)selenopheno[2,3-d]pyrimidines.
AID1257012	Antioxidant activity assessed as ABTS radical scavenging activity after 10 mins by UV-Visible spectrophotometric analysis	2015	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 25, Issue:23	Chrysin-benzothiazole conjugates as antioxidant and anticancer agents.
AID1191655	Antioxidant activity assessed as ABTS scavenging activity after 6 mins by spectrophotometry	2015	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 25, Issue:5	Schiff's bases of quinazolinone derivatives: Synthesis and SAR studies of a novel series of potential anti-inflammatory and antioxidants.
AID1194494	Antioxidant activity assessed as ferric-reducing antioxidant power after 20 mins at 50 degC by UV spectrophotometry	2015	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 25, Issue:8	New septanoside and 20-hydroxyecdysone septanoside derivative from Atriplex portulacoides roots with preliminary biological activities.
AID1453463	Antioxidant activity of the compound in phosphate buffer at pH 6.6 assessed as potassium ferric cyanide ion reducing activity after 20 mins by spectrophotometric method	2017	Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13	Synthesis of methanesulphonamido-benzimidazole derivatives as gastro-sparing antiinflammatory agents with antioxidant effect.
AID363318	DPPH radical scavenging activity assessed as ratio of drug concentration to DPPH concentration producing 50% decrease in DPPH after 5 mins	2008	European journal of medicinal chemistry, Jun, Volume: 43, Issue:6	Synthesis and biological activities of a series of 4,5-diaryl-3-hydroxy-2(5H)-furanones.
AID1234179	Antioxidative activity assessed as DPPH radical scavenging activity	2015	Journal of natural products, Jul-24, Volume: 78, Issue:7	Indole Alkaloids from Chaetomium globosum.
AID764772	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins	2013	Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17	Design, synthesis and pharmacological evaluation of (E)-3,4-dihydroxy styryl sulfonamides derivatives as multifunctional neuroprotective agents against oxidative and inflammatory injury.
AID567049	Antioxidant activity assessed as inhibition of heme protein-dependent lipid peroxidation at 1 mM	2011	European journal of medicinal chemistry, Jan, Volume: 46, Issue:1	Design, synthesis and pharmacobiological evaluation of novel acrylic acid derivatives acting as lipoxygenase and cyclooxygenase-1 inhibitors with antioxidant and anti-inflammatory activities.
AID620060	Antioxidant activity assessed as hydrogen peroxide scavenging activity at 100 ug/ml relative to control	2011	European journal of medicinal chemistry, Oct, Volume: 46, Issue:10	Synthesis and antioxidant activity of oxazolyl/thiazolylsulfonylmethyl pyrazoles and isoxazoles.
AID1193494	Thermodynamic equilibrium solubility, log S of the compound in simulated gastric fluid at pH 1.2 at RT after 4 hrs by 96 well plate method	2015	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7	Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery.
AID625295	Drug Induced Liver Injury Prediction System (DILIps) validation dataset; compound DILI positive/negative as observed in Pfizer data	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID1615198	Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins under dark condition	2019	European journal of medicinal chemistry, Oct-01, Volume: 179	Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells.
AID496830	Antimicrobial activity against Leishmania major	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
AID1193294	Inhibition of tyrosinase (unknown origin)	2015	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7	Effect of the tyrosinase inhibitor (S)-N-trans-feruloyloctopamine from garlic skin on tyrosinase gene expression and melanine accumulation in melanoma cells.
AID685398	Antioxidant activity assessed as hydrogen peroxide radical scavenging activity	2012	European journal of medicinal chemistry, Oct, Volume: 56	Docking studies, synthesis, characterization of some novel oxazine substituted 9-anilinoacridine derivatives and evaluation for their antioxidant and anticancer activities as topoisomerase II inhibitors.
AID1194493	Antioxidant activity assessed as ABTS radical scavenging activity incubated for 6 mins	2015	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 25, Issue:8	New septanoside and 20-hydroxyecdysone septanoside derivative from Atriplex portulacoides roots with preliminary biological activities.
AID776428	Antioxidant activity assessed as DPPH free radical scavenging activity after 20 mins by UV-visible spectrophotometric analysis	2013	European journal of medicinal chemistry, Nov, Volume: 69	Synthesis, antimicrobial, antioxidant activities of novel 6-aryl-5-cyano thiouracil derivatives.
AID1650988	Antioxidant activity assessed as reduction of colourless Fe3+-TPTZ complex to coloured Fe2+-TPTZ complex measured after 5 mins by FRAP assay	2020	Bioorganic & medicinal chemistry letters, 02-15, Volume: 30, Issue:4	Synthesis and biological evaluation of 4-arylcoumarins as potential anti-Alzheimer's disease agents.
AID1313279	Antioxidant activity assessed as DPPH radical scavenging activity at 20 ug/ml after 20 mins by spectrophotometry relative to control	2016	Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15	Synthesis of lignan conjugates via cyclopropanation: Antimicrobial and antioxidant studies.
AID1155650	Neuroprotective activity against amyloid beta (25 to 35)-induced cell death in human SH-SY5Y cells assessed as cell viability at 10 uM after 24 hrs by MTT assay relative to control	2014	Journal of natural products, Jun-27, Volume: 77, Issue:6	Lignans from the fruit of Schisandra glaucescens with antioxidant and neuroprotective properties.
AID1631497	Antioxidant activity after 5 mins by NBT assay	2016	Journal of natural products, Apr-22, Volume: 79, Issue:4	Minor Pyranonaphthoquinones from the Apothecia of the Lichen Ophioparma ventosa.
AID464441	Antioxidant activity assessed as trolox equivalent of ABTS free radical scavenging activity after 6 mins by TRAP assay	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis of new spiroindolinones incorporating a benzothiazole moiety as antioxidant agents.
AID549264	Antioxidant activity assessed as DPPH radical scavenging activity at 100 ug/ml after 30 mins	2010	Journal of natural products, Nov-29, Volume: 73, Issue:11	Inhibition of melanogenesis and oxidation by protocatechuic acid from Origanum vulgare (oregano).
AID539844	Antioxidant activity assessed as DPPH radical scavenging activity at 500 ug by spectrophotometry relative to control	2010	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24	Synthesis, antimicrobial and antioxidant evaluation of quinolines and bis(indolyl)methanes.
AID1692038	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins under dark condition by spectrophotometric analysis	2020	European journal of medicinal chemistry, Jul-01, Volume: 197	Antioxidant activity of novel quinazolinones bearing sulfonamide: Potential radiomodulatory effects on liver tissues via NF-κB/ PON1 pathway.
AID1360873	Antioxidant activity assessed as ferric ion reduction by measuring FeSO4 equivalents reducing Fe3+-TPTZ to Fe2+-TPTZ at 40 ug/ml after 25 mins by FRAP assay	2018	European journal of medicinal chemistry, Jul-15, Volume: 155	Synthesis and biological evaluation of new coumarins bearing 2,4-diaminothiazole-5-carbonyl moiety.
AID1570051	Cytoprotective against H2O2-induced cell death in human U251 cells assessed as increase in cell viability at 100 uM preincubated for 24 hrs followed by H2O2 induction and measured after 1 hr by MTS assay (Rvb = 50%)	2019	European journal of medicinal chemistry, Oct-15, Volume: 180	Design, synthesis and biological evaluation of hydroxypyridinone-coumarin hybrids as multimodal monoamine oxidase B inhibitors and iron chelates against Alzheimer's disease.
AID401236	Inhibition of superoxide production in PMNCs by NBT reduction assay	2004	Journal of natural products, Apr, Volume: 67, Issue:4	Madhucosides A and B, protobassic acid glycosides from Madhuca indica with inhibitory activity on free radical release from phagocytes.
AID386936	Antioxidant activity assessed as hydroxyl radical scavenging activity	2008	European journal of medicinal chemistry, Oct, Volume: 43, Issue:10	The antioxidant activity of 2-(4(or 2)-hydroxyl-5-chloride-1,3-benzene-di-sulfanimide)-chitosan.
AID246191	Effective concentration to induce a quorum signal in Vibrio harveyi(by binding Lux P protein)	2005	Bioorganic & medicinal chemistry letters, May-02, Volume: 15, Issue:9	Quorum sensing in Vibrio harveyi: probing the specificity of the LuxP binding site.
AID496824	Antimicrobial activity against Toxoplasma gondii	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
AID648401	Antioxidant activity of the compound assessed as DPPH radical scavenging activity at 200 ug/ml after 20 mins	2012	European journal of medicinal chemistry, May, Volume: 51	Facile synthesis, characterization and pharmacological activities of 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles and 5,6-dihydro-3,6-disubstituted-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles.
AID1453052	Antioxidant activity assessed as inhibition of DPPH radical generation at 0.01 mg/ml after 20 mins under dark condition by UV-Visible spectrophotometric analysis relative to control	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Synthesis, characterization, molecular docking and in vitro antimalarial properties of new carboxamides bearing sulphonamide.
AID1533608	Selectivity index, ratio of IC50 for human serum BChE to IC50 for Electric eel AChE	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Design and development of some phenyl benzoxazole derivatives as a potent acetylcholinesterase inhibitor with antioxidant property to enhance learning and memory.
AID456320	Antioxidant activity assessed as ABTS radical scavenging activity	2010	Bioorganic & medicinal chemistry, Jan-01, Volume: 18, Issue:1	Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids.
AID478246	Antioxidant activity in Wistar albino rat assessed as reduced glutathione level	2010	European journal of medicinal chemistry, May, Volume: 45, Issue:5	Synthesis, spectral characterization and bioassay of 3,3'-(1,4-phenylene)-bis[2-alkoxycarbonyl-alkyl)-2-thio-benzoxa-phosphinines].
AID405490	Antioxidant activity assessed as DPPH free radical scavenging activity at 1 mM	2008	Journal of natural products, Jun, Volume: 71, Issue:6	(Iso)-quinoline alkaloids from fungal fruiting bodies of Cortinarius subtortus.
AID762734	Antioxidant activity against ferric chloride-induced lipid peroxidation using egg lecithin at 50 ug/ml after 1 hr	2013	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 23, Issue:16	Novel pyrazoline amidoxime and their 1,2,4-oxadiazole analogues: synthesis and pharmacological screening.
AID762899	Total antioxidant capacity of the compound at 100 uM relative to control	2013	Journal of natural products, Aug-23, Volume: 76, Issue:8	Phaeolschidins A-E, five hispidin derivatives with antioxidant activity from the fruiting body of Phaeolus schweinitzii collected in the Tibetan Plateau.
AID323921	Enhancement of HCV RNA replication in OR6 cells after 72 hrs by luciferase reporter assay	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture.
AID722940	Inhibition of human recombinant GSK-3beta using GS2 peptide as substrate and [gamma33P]-ATP at 50 uM after 30 mins by scintillation counting	2013	European journal of medicinal chemistry, Feb, Volume: 60	Evidence for a new binding mode to GSK-3: allosteric regulation by the marine compound palinurin.
AID437942	Antioxidant activity in Wistar rat brain assessed as reduction in glutathione content	2010	European journal of medicinal chemistry, Jan, Volume: 45, Issue:1	Synthesis, spectral characterization and biological evaluation of phosphorylated derivatives of galanthamine.
AID614058	Inhibition of bovine testes hyaluronidase at 100 uM after 30 mins at pH 5 by turbidimetric analysis	2011	European journal of medicinal chemistry, Sep, Volume: 46, Issue:9	Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase.
AID1611501	Antioxidant activity assessed as DPPH free radical scavenging activity at 300 uM incubated for 60 mins by spectrophotometric method relative to control	2019	Bioorganic & medicinal chemistry letters, 12-15, Volume: 29, Issue:24	Synthesis and evaluation of 1,3,5-triazine derivatives as sunscreens useful to prevent skin cancer.
AID327928	DPPH radical scavenging activity	2008	Journal of natural products, Feb, Volume: 71, Issue:2	Structural characterization and DPPH radical scavenging activity of an arabinoglucogalactan from Panax notoginseng root.
AID427666	Antioxidant activity assessed as superoxide anion radical scavenging activity by spectrophotometry	2009	Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13	Potential antioxidants and tyrosinase inhibitors from synthetic polyphenolic deoxybenzoins.
AID1498380	Antioxidant activity assessed as DPPH radical scavenging activity at 100 ug/ml measured after 30 mins	2018	Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12	Synthesis of sulfadiazinyl acyl/aryl thiourea derivatives as calf intestinal alkaline phosphatase inhibitors, pharmacokinetic properties, lead optimization, Lineweaver-Burk plot evaluation and binding analysis.
AID614054	Inhibition of bovine testes hyaluronidase at 460 uM after 30 mins at pH 5 by turbidimetric analysis	2011	European journal of medicinal chemistry, Sep, Volume: 46, Issue:9	Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase.
AID1347863	Inhibition of alpha-MSH-induced TRP-1 expression in human A375 cells at 25 uM after 24 hrs by Western blot method	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	Design, synthesis and evaluation of novel dihydrostilbene derivatives as potential anti-melanogenic skin-protecting agents.
AID1496217	Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins in dark by spectrophotometric method	2018	Bioorganic & medicinal chemistry letters, 07-01, Volume: 28, Issue:12	Valproic acid induces three novel cytotoxic secondary metabolites in Diaporthe sp., an endophytic fungus from Datura inoxia Mill.
AID492140	Antioxidant activity assessed as formazan formation induced absorbance changes at 25 ppm at 570 nm at 37 degC for 6 hrs by MTT assay	2010	Journal of natural products, Jul-23, Volume: 73, Issue:7	An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.
AID1053469	DPPH radical scavenging activity assessed as reducing ability at 5 to 100 uM after 30 mins by spectrophotometry	2013	Journal of medicinal chemistry, Nov-14, Volume: 56, Issue:21	Discovery of tryptanthrin derivatives as potent inhibitors of indoleamine 2,3-dioxygenase with therapeutic activity in Lewis lung cancer (LLC) tumor-bearing mice.
AID1730962	Antioxidant activity assessed as nitric oxide radical scavenging activity at 50 ug/ml (Rvb = 25.8 to 41.6 %)	2021	Bioorganic & medicinal chemistry letters, 03-15, Volume: 36	Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme.
AID1250853	Inhibition of baker's yeast alpha-glucosidase type-1 using p-nitrophenyl-alpha-D-glucopyranoside as substrate preincubated for 30 mins followed by substrate addition measured after 20 mins by microplate reader analysis	2015	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20	New arylalkanones from Horsfieldia macrobotrys, effective antidiabetic agents concomitantly inhibiting α-glucosidase and free radicals.
AID1663503	Antioxidant activity assessed as reduction in lipid peroxidation	2020	Bioorganic & medicinal chemistry letters, 08-01, Volume: 30, Issue:15	3,4-Dihydroxyphenethyl nitrate with nitric oxide releasing, antioxidant, hypoglycemic and hypolipidemic effects.
AID1555220	Inhibition of mushroom tyrosinase using L-dopa as substrate incubated for 30 mins by spectrophotometric method
AID1693239	Antioxidant activity assessed as DPPH radical scavenging activity incubated for 20 mins in dark conditions	2021	Bioorganic & medicinal chemistry letters, 01-15, Volume: 32	Synthesis, biological evaluation, and NMR studies of 3-fluorinated derivatives of 3',4',5'-trihydroxyflavone and 3',4',5'-trimethoxyflavone.
AID1194495	Antioxidant activity assessed as catalase activity by measuring hydrogen peroxide disappearance per mg protein measured for 1 min at 25 degC	2015	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 25, Issue:8	New septanoside and 20-hydroxyecdysone septanoside derivative from Atriplex portulacoides roots with preliminary biological activities.
AID382109	Distribution coefficient, log D at pH 1.0 after 4 hrs by shake flask method	2008	Bioorganic & medicinal chemistry, May-01, Volume: 16, Issue:9	Novel antioxidant agents deriving from molecular combination of Vitamin C and NO-donor moieties.
AID762741	Antioxidant activity assessed as DPPH free radical scavenging activity at 100 ug/ml after 20 mins	2013	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 23, Issue:16	Novel pyrazoline amidoxime and their 1,2,4-oxadiazole analogues: synthesis and pharmacological screening.
AID409960	Inhibition of bovine brain MAOB	2008	Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21	Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
AID1487492	Antioxidant activity assessed as H2O2 free radical scavenging activity by spectrophotometric analysis	2017	Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16	Synthesis, antioxidant, antifungal, molecular docking and ADMET studies of some thiazolyl hydrazones.
AID1057590	Antioxidant activity assessed as DPPH radical scavenging activity at 25 to 100 uM after 30 mins	2013	Journal of medicinal chemistry, Nov-27, Volume: 56, Issue:22	Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo.
AID502059	Antioxidant activity assessed as ABTS radical scavenging activity at 50 ug/ml	2010	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17	InCl3 mediated one-pot multicomponent synthesis, anti-microbial, antioxidant and anticancer evaluation of 3-pyranyl indole derivatives.
AID1242828	Antioxidant activity assessed as DPPH redical scavenging activity incubated for 2 hrs in dark condition	2015	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 25, Issue:18	Dietziamides, novel tetramic acid dimers from Dietzia timorensis MZ-3 with antioxidative activity.
AID1453462	Antioxidant activity of the compound in phosphate buffer at pH 6.6 assessed as potassium ferric cyanide ion reducing activity at 50 umol/ml after 20 mins by spectrophotometric method relative to control	2017	Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13	Synthesis of methanesulphonamido-benzimidazole derivatives as gastro-sparing antiinflammatory agents with antioxidant effect.
AID1594574	Antioxidant activity assessed as DPPH radical scavenging activity incubated for 15 to 20 mins by UV-visible spectrometry	2019	Bioorganic & medicinal chemistry letters, 06-01, Volume: 29, Issue:11	Cu-mediated synthesis of differentially substituted diazepines as AChE inhibitors; validation through molecular docking and Lipinski's filter to develop novel anti-neurodegenerative drugs.
AID1366176	Antioxidant activity assessed as DPPH free radical scavenging activity at 200 ug/ml after 30 mins by spectrophotometric analysis	2017	Bioorganic & medicinal chemistry, 11-01, Volume: 25, Issue:21	Design and synthesis of benzimidazole-based Rho kinase inhibitors for the treatment of glaucoma.
AID626498	Antioxidant activity assessed as superoxide anioin radical scavenging activity after 5 mins by spectrophotometric analysis	2011	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 21, Issue:22	Synthesis and antioxidant activities of novel 4-Schiff base-7-benzyloxy-coumarin derivatives.
AID1267476	Antioxidant activity assessed as DPPH radical scavenging activity at 2 mM after 30 mins	2016	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1	Bioactive minor components of the total salvianolic acids injection prepared from Salvia miltiorrhiza Bge.
AID548961	Antioxidant activity of the compound assessed as reducing activity of DPPH at 0.1 mM after 60 mins	2010	Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23	Does conjugation of antioxidants improve their antioxidative/anti-inflammatory potential?
AID416923	Antioxidant activity assessed as superoxide anion scavenging activity by NBT reduction method	2009	European journal of medicinal chemistry, Feb, Volume: 44, Issue:2	Cytotoxic, antioxidant activities and structure activity relationship of some newly synthesized terpenoidal oxaliplatin analogs.
AID232873	Free radical scavenging assessed as color reduction of DPPH	2002	Journal of medicinal chemistry, Jan-17, Volume: 45, Issue:2	Synthesis and characterization of a series of novel monoacylated ascorbic acid derivatives, 6-O-acyl-2-O-alpha-D-glucopyranosyl-L-ascorbic acids, as skin antioxidants.
AID387798	Cytoprotective activity against hydrogen peroxide-induced cell death in human HL-60 cells assessed as cell viability at 30 uM after 24 hrs by trypan blue exclusion assay	2008	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 18, Issue:19	2,2'-Pyridoin derivatives protect HL-60 cells against oxidative stress.
AID1268019	Antioxidant activity assessed as DPPH free radical scavenging activity at 100 ug/ml after 20 mins by UV-vis spectrophotometry analysis	2016	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2	Synthesis of novel coumarin appended bis(formylpyrazole) derivatives: Studies on their antimicrobial and antioxidant activities.
AID1610134	Antiproliferative activity against human CFPAC-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Dec-15, Volume: 184	Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives.
AID687640	Inhibition of mushroom tyrosinase using as L-DOPA substrate after 2 mins by spectrophotometric analysis	2011	Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11	Tyrosinase inhibitory activity of a 6-isoprenoid-substituted flavanone isolated from Dalea elegans.
AID401336	Antioxidant activity assessed by superoxide anion scavenging assay	1996	Journal of natural products, Feb, Volume: 59, Issue:2	Natural polyphenols (vegetable tannins) as drugs: possible modes of action.
AID496817	Antimicrobial activity against Trypanosoma cruzi	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
AID497111	Antioxidant activity assessed as DPPH free radical scavenging activity after 1 hr	2010	Bioorganic & medicinal chemistry, Aug-01, Volume: 18, Issue:15	Synthesis and biological evaluation of arylidene analogues of Meldrum's acid as a new class of antimalarial and antioxidant agents.
AID1405935	Antioxidant activity assessed as DPPH radical scavenging activity	2018	European journal of medicinal chemistry, Aug-05, Volume: 156	Current progress on antioxidants incorporating the pyrazole core.
AID174641	Effect of AOS scavenger on ventricular fibrillation (VF), arrhythmias induced by ischemia-reperfusion in anesthetized rat, incidence at 3 mg/kg	1988	Journal of medicinal chemistry, Apr, Volume: 31, Issue:4	Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID1428663	Antiradical activity assessed as gallic acid equivalents of Foline-Ciocalteu reagent reducing capacity at 1 mM preincubated for 5 mins followed by Na2CO3 addition measured after 90 mins	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Novel flavonolignan hybrid antioxidants: From enzymatic preparation to molecular rationalization.
AID294918	Antioxidant activity assessed as nitric oxide radical scavenging activity at 1.2 ug/ml after 150 mins	2007	European journal of medicinal chemistry, Aug, Volume: 42, Issue:8	Syntheses of new tetrasubstituted thiophenes as novel anti-inflammatory agents.
AID1663837	Antioxidant activity assessed as trolox equivalent antioxidant capacity	2020	Bioorganic & medicinal chemistry letters, 07-15, Volume: 30, Issue:14	Isolation and biological activity of agrostophillinol from kaffir lime (Citrus hystrix) leaves.
AID1610138	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Dec-15, Volume: 184	Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives.
AID446405	Antioxidant activity assessed as DPPH radical scavenging activity	2010	Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3	Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a D3 receptor preferring agonist: potent in vivo activity in Parkinson's disease animal models.
AID1396238	Antioxidant activity assessed as DPPH-radical scavenging activity at 1 mM incubated for 30 mins under dark condition	2018	Bioorganic & medicinal chemistry, 08-07, Volume: 26, Issue:14	The tyrosinase inhibitory effects of isoxazolone derivatives with a (Z)-β-phenyl-α, β-unsaturated carbonyl scaffold.
AID592648	Antioxidant activity assessed as DPPH free radical scavenging activity at 100 uM after 30 mins	2011	Bioorganic & medicinal chemistry, Apr-01, Volume: 19, Issue:7	Synthesis and anti-melanogenic activity of hydroxyphenyl benzyl ether analogues.
AID588211	Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans	2010	Chemical research in toxicology, Jan, Volume: 23, Issue:1	Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
AID549265	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins	2010	Journal of natural products, Nov-29, Volume: 73, Issue:11	Inhibition of melanogenesis and oxidation by protocatechuic acid from Origanum vulgare (oregano).
AID1462746	Antioxidant activity assessed as DPPH free radical scavenging activity by measuring radical-scavenging activity factor (moles of radicals scavenged by each mol of antioxidant) at 20 uM measured at 15 mins by HPLC	2017	Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20	Structural evidence for the DPPH radical-scavenging mechanism of 2-O-α-d-glucopyranosyl-l-ascorbic acid.
AID448092	Antioxidant activity assessed as DPPH radical scavenging after 30 mins	2009	European journal of medicinal chemistry, Nov, Volume: 44, Issue:11	Antioxidant and antibacterial studies of arylazopyrazoles and arylhydrazonopyrazolones containing coumarin moiety.
AID1599716	Antioxidant activity assessed as DPPH free radical scavenging activity incubated for 30 mins in dark condition by spectrophotometric analysis	2019	Bioorganic & medicinal chemistry, 10-15, Volume: 27, Issue:20	Synthesis of N-hydroxycinnamoyl amide derivatives and evaluation of their anti-oxidative and anti-tyrosinase activities.
AID1730960	Antioxidant activity assessed as DPPH radical scavenging activity at 100 ug/ml (Rvb = 22 to 40.2 %)	2021	Bioorganic & medicinal chemistry letters, 03-15, Volume: 36	Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme.
AID762334	Antioxidant activity assessed as DPPH free radical scavenging activity at 50 ug after 30 mins by spectrophotometry	2013	European journal of medicinal chemistry, Aug, Volume: 66	Microwave-assisted synthesis of some new pyrazolopyridines and their antioxidant, antitumor and antimicrobial activities.
AID1487483	Antioxidant activity assessed as DPPH free radical scavenging activity at 60 ug/ml after 15 mins by spectrophotometric method	2017	Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16	Synthesis, antioxidant, antifungal, molecular docking and ADMET studies of some thiazolyl hydrazones.
AID1294868	Antioxidant activity assessed as DPPH free radical scavenging activity incubated for 30 mins in dark condition by spectrophotometric method	2016	Bioorganic & medicinal chemistry letters, 05-15, Volume: 26, Issue:10	Synthesis, molecular properties prediction and anticancer, antioxidant evaluation of new edaravone derivatives.
AID1762401	Inhibition of porcine liver carboxylesterase using 4-NPA as substrate preincubated for 10 mins followed by substrate addition by spectrophotometric analysis	2021	European journal of medicinal chemistry, Jun-05, Volume: 218	Novel potent bifunctional carboxylesterase inhibitors based on a polyfluoroalkyl-2-imino-1,3-dione scaffold.
AID1250854	Inhibition of rat intestinal Maltase using maltose as substrate assessed as glucose release after 10 mins by glucose oxidase method	2015	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20	New arylalkanones from Horsfieldia macrobotrys, effective antidiabetic agents concomitantly inhibiting α-glucosidase and free radicals.
AID402015	Antioxidant activity assessed as DPPH radical scavenging activity	2005	Journal of natural products, May, Volume: 68, Issue:5	Quinones from Chirita eburnea.
AID720995	Antioxidant activity assessed as DPPH scavenging activity after 30 mins by spectrophotometry	2013	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1	Synthesis and antioxidant activities of 2-oxo-quinoline-3-carbaldehyde Schiff-base derivatives.
AID382104	Antioxidant activity Wistar rat hepatocyte membrane assessed as Fe(3+)-ADP/NADPH-induced lipid peroxidation at 50 uM by TBA assay	2008	Bioorganic & medicinal chemistry, May-01, Volume: 16, Issue:9	Novel antioxidant agents deriving from molecular combination of Vitamin C and NO-donor moieties.
AID1204902	Antioxidant activity assessed as DPPH free radical scavenging activity measured as decoloration of a MeOH solution after 10 mins by spectrophotometry	2015	Journal of natural products, Feb-27, Volume: 78, Issue:2	Iridoid glycosides from Barleria lupulina.
AID1663836	Antioxidant activity assessed as DPPH radical scavenging activity	2020	Bioorganic & medicinal chemistry letters, 07-15, Volume: 30, Issue:14	Isolation and biological activity of agrostophillinol from kaffir lime (Citrus hystrix) leaves.
AID1264278	Antioxidant activity assessed as DPPH free radical scavenging activity at 25 ug/ml after 30 mins by spectrophotometric assay	2015	European journal of medicinal chemistry, Nov-02, Volume: 104	Synthesis and pharmacological evaluation of some new fluorine containing hydroxypyrazolines as potential anticancer and antioxidant agents.
AID1511011	Antioxidant activity assessed as ABTS radical scavenging activity incubated for 40 mins	2019	European journal of medicinal chemistry, Oct-15, Volume: 180	Discovery of new potent dual sigma receptor/GluN2b ligands with antioxidant property as neuroprotective agents.
AID1479538	Antioxidant activity assessed as DPPH radical scavenging activity incubated in dark for 20 mins	2018	Journal of medicinal chemistry, 02-22, Volume: 61, Issue:4	The Synthesized Plant Metabolite 3,4,5-Tri-O-Galloylquinic Acid Methyl Ester Inhibits Calcium Oxalate Crystal Growth in a Drosophila Model, Downregulates Renal Cell Surface Annexin A1 Expression, and Decreases Crystal Adhesion to Cells.
AID691694	Antioxidant activity of the compound in phosphate buffer at pH 6.6 assessed as potassium ferric cyanide ion reducing activity at 6.25 to 100 uM after 20 mins	2012	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20	Antioxidant properties of Mannich bases.
AID513611	Inhibition of NO production in BAEC assessed as inhibition of Ca2+ influx at 1 mM	2006	Nature chemical biology, Nov, Volume: 2, Issue:11	Nitric oxide activates TRP channels by cysteine S-nitrosylation.
AID1202844	Antioxidant activity assessed as ferric reducing antioxidant power at 0.1 mg/ml by FRAP assay	2015	Journal of natural products, Feb-27, Volume: 78, Issue:2	Puupehenol, a potent antioxidant antimicrobial meroterpenoid from a Hawaiian deep-water Dactylospongia sp. sponge.
AID770309	Antioxidant activity assessed as inhibition of DPPH-induced free radical generation at 1 to 500 uM after 30 mins relative to control	2013	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 23, Issue:19	Discovery of novel (1S)-(-)-verbenone derivatives with anti-oxidant and anti-ischemic effects.
AID283705	DPPH radical scavenging activity at 40 umol/L relative to control	2007	Journal of natural products, Apr, Volume: 70, Issue:4	Bioactive metabolites from the Caribbean sponge Aka coralliphagum.
AID1635491	Neuroprotective activity against H2O2-induced oxidative damage in human SH-SY5Y cells assessed as increase in cell viability at 20 uM incubated for 2 hrs followed by H2O2 challenge measured after 24 hrs by MTT assay	2016	Journal of medicinal chemistry, 06-23, Volume: 59, Issue:12	Benzylpiperidine-Linked Diarylthiazoles as Potential Anti-Alzheimer's Agents: Synthesis and Biological Evaluation.
AID1405942	Antioxidant activity assessed as DPPH radical scavenging activity at 10 ug/ml after 20 mins by UV absorbance method relative to control	2018	European journal of medicinal chemistry, Aug-05, Volume: 156	Current progress on antioxidants incorporating the pyrazole core.
AID1168136	Antioxidant activity assessed as DPPH free radical scavenging activity after 60 mins by spectrophotometry	2014	European journal of medicinal chemistry, Nov-24, Volume: 87	PASS-assisted design, synthesis and antioxidant evaluation of new butylated hydroxytoluene derivatives.
AID374242	Inhibition of bleomycin-induced DNA damage assessed as absorbance at 532 nm after 1 hr at 37 degC	2009	European journal of medicinal chemistry, Apr, Volume: 44, Issue:4	New acyclic nucleosides analogues as potential analgesic, anti-inflammatory, anti-oxidant and anti-microbial derived from pyrimido[4,5-b]quinolines.
AID1487490	Antioxidant activity assessed as H2O2 free radical scavenging activity at 80 ug/ml after 10 to 15 mins by spectrophotometric analysis	2017	Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16	Synthesis, antioxidant, antifungal, molecular docking and ADMET studies of some thiazolyl hydrazones.
AID1768734	Inhibition of equine serum BuChE by Ellman's method	2021	Bioorganic & medicinal chemistry letters, 10-01, Volume: 49	Design, synthesis and biological evaluation of naringenin carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
AID36973	Inhibitory constant against Alpha-amylase	2000	Bioorganic & medicinal chemistry letters, Jul-17, Volume: 10, Issue:14	Kinetic characterisation of ene-diol-based inhibitors of alpha-amylase.
AID1202555	Antioxidant activity assessed as inhibition of ABTS free radical scavenging activity after 10 mins by spectrophotometry relative to control	2015	European journal of medicinal chemistry, , Volume: 96	Design, synthesis and biological evaluation of quinazoline derivatives as anti-trypanosomatid and anti-plasmodial agents.
AID1420841	Antioxidant activity assessed as DPPH radical scavenging activity at 20 uM measured after 30 mins	2018	European journal of medicinal chemistry, Oct-05, Volume: 158	Design, synthesis and identification of novel substituted 2-amino thiazole analogues as potential anti-inflammatory agents targeting 5-lipoxygenase.
AID1496213	Antioxidant activity assessed as DPPH free radical scavenging activity at 50 uM after 30 mins in dark by spectrophotometric method relative to control	2018	Bioorganic & medicinal chemistry letters, 07-01, Volume: 28, Issue:12	Valproic acid induces three novel cytotoxic secondary metabolites in Diaporthe sp., an endophytic fungus from Datura inoxia Mill.
AID549263	Antioxidant activity assessed as DPPH radical scavenging activity at 20 ug/ml after 30 mins	2010	Journal of natural products, Nov-29, Volume: 73, Issue:11	Inhibition of melanogenesis and oxidation by protocatechuic acid from Origanum vulgare (oregano).
AID1268016	Antioxidant activity assessed as DPPH free radical scavenging activity at 25 ug/ml after 20 mins by UV-vis spectrophotometry analysis	2016	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2	Synthesis of novel coumarin appended bis(formylpyrazole) derivatives: Studies on their antimicrobial and antioxidant activities.
AID1172552	Antioxidant activity assessed as DPPH radical scavenging activity relative to untreated control	2014	European journal of medicinal chemistry, Nov-24, Volume: 87	Synthetic derivatives of aromatic abietane diterpenoids and their biological activities.
AID690850	Antioxidant activity assessed as DPPH radical scavenging activity	2012	Journal of medicinal chemistry, 06-28, Volume: 55, Issue:12	Structure-activity relationship study of N⁶-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N⁶-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine analogues: development of highly selective D3 dopamine receptor agonists along with a highly potent D2/D3 agoni
AID1352204	Antioxidant activity assessed as superoxide dismutase-like activity by measuring inhibition of xanthine oxidase-induced superoxide anion level measured ever 30 secs for 5 mins by NBT reduction assay	2018	European journal of medicinal chemistry, Feb-10, Volume: 145	Design, synthesis, biological evaluation and docking studies of new 3-(4,5-dihydro-1H-pyrazol/isoxazol-5-yl)-2-phenyl-1H-indole derivatives as potent antioxidants and 15-lipoxygenase inhibitors.
AID648403	Antioxidant activity of the compound assessed as DPPH radical scavenging activity at 800 ug/ml after 20 mins	2012	European journal of medicinal chemistry, May, Volume: 51	Facile synthesis, characterization and pharmacological activities of 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles and 5,6-dihydro-3,6-disubstituted-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles.
AID1743176	Antioxidant activity assessed as trolox equivalent of ABTS radical scavenging activity measured after 1 hr by UV-vis spectrophotometric method	2020	European journal of medicinal chemistry, Dec-15, Volume: 208	Multiple biological active 4-aminopyrazoles containing trifluoromethyl and their 4-nitroso-precursors: Synthesis and evaluation.
AID678494	Antioxidant activity assessed as superoxide radical scavenging activity at 100 uM after 5 mins by NBT reduction assay	2012	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18	Synthesis, biological evaluation, and docking studies of 3-(substituted)-aryl-5-(9-methyl-3-carbazole)-1H-2-pyrazolines as potent anti-inflammatory and antioxidant agents.
AID478248	Antioxidant activity in Wistar albino rat assessed as catalase level	2010	European journal of medicinal chemistry, May, Volume: 45, Issue:5	Synthesis, spectral characterization and bioassay of 3,3'-(1,4-phenylene)-bis[2-alkoxycarbonyl-alkyl)-2-thio-benzoxa-phosphinines].
AID744461	Antioxidant activity of the compound assessed as DPPH free radical scavenging activity at 250 uM after 60 mins by spectrophotometric analysis relative to control	2013	European journal of medicinal chemistry, May, Volume: 63	Synthesis and biological activities of some novel aminomethyl derivatives of 4-substituted-5-(2-thienyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones.
AID771144	Antioxidant activity assessed as reduction of K3FeCN6 at 1 to 500 uM by spectrophotometric analysis in presence of FeCl3	2013	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 23, Issue:19	Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs).
AID1555975	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by Ellman's method	2019	European journal of medicinal chemistry, Sep-01, Volume: 177	Design, synthesis, and biological evaluation of rutacecarpine derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease.
AID491005	Antioxidant activity assessed as DPPH radical scavenging activity at 100 uM	2010	European journal of medicinal chemistry, Jul, Volume: 45, Issue:7	Synthesis and bioassay of pyrrolyl oxazolines and thiazolines.
AID365747	Antioxidant activity assessed as DPPH radical scavenging activity	2008	Bioorganic & medicinal chemistry, Aug-15, Volume: 16, Issue:16	Inhibitory effects of polymethoxy flavones isolated from Citrus reticulate on degranulation in rat basophilic leukemia RBL-2H3: enhanced inhibition by their combination.
AID401337	Antioxidant activity assessed by hydroxyl radical scavenging assay	1996	Journal of natural products, Feb, Volume: 59, Issue:2	Natural polyphenols (vegetable tannins) as drugs: possible modes of action.
AID453276	Antioxidant activity assessed as hydrogen peroxide scavenging activity by lucigenin oxidation assay	2009	Bioorganic & medicinal chemistry, Oct-15, Volume: 17, Issue:20	Synthesis and antioxidant properties of new chromone derivatives.
AID1611502	Antioxidant activity assessed as DPPH free radical scavenging activity at 200 uM incubated for 60 mins by spectrophotometric method relative to control	2019	Bioorganic & medicinal chemistry letters, 12-15, Volume: 29, Issue:24	Synthesis and evaluation of 1,3,5-triazine derivatives as sunscreens useful to prevent skin cancer.
AID1193498	Thermodynamic equilibrium solubility, log S of the compound simulated gastric fluid at pH 1.2 at RT after 24 hrs by shake-flask method	2015	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7	Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery.
AID678495	Antioxidant activity assessed as H2O2-induced hydroxyl radical scavenging activity at 100 uM after 5 mins by spectrophotometry	2012	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18	Synthesis, biological evaluation, and docking studies of 3-(substituted)-aryl-5-(9-methyl-3-carbazole)-1H-2-pyrazolines as potent anti-inflammatory and antioxidant agents.
AID1155652	Antioxidant activity assessed as ferric ion reducing activity expressed as Fe(II) using ferrous-TPTZ by FRAP assay	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, biological evaluation and docking study of 3-aroyl-1-(4-sulfamoylphenyl)thiourea derivatives as 15-lipoxygenase inhibitors.
AID502058	Antioxidant activity assessed as DPPH radical scavenging activity	2010	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17	InCl3 mediated one-pot multicomponent synthesis, anti-microbial, antioxidant and anticancer evaluation of 3-pyranyl indole derivatives.
AID219598	Compound was tested for the inhibition of xanthine oxidase; Inactive	2000	Bioorganic & medicinal chemistry letters, Dec-18, Volume: 10, Issue:24	Antioxidant activity and xanthine oxidase inhibition activity of reductic acid: ascorbic acid analogue.
AID691692	Antioxidant activity of the compound assessed as DPPH radical scavenging activity at 50 uM	2012	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20	Antioxidant properties of Mannich bases.
AID693513	Antioxidant activity assessed as inhibition of H2O2 radical scavenging activity at 75 ug/mL by spectrophotometric analysis relative to control	2012	European journal of medicinal chemistry, Dec, Volume: 58	Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d]pyrimidine derivatives.
AID753094	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by spectrophotometric analysis	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis, cytotoxic activity and DNA-interaction studies of novel anthraquinone-thiosemicarbazones with tautomerizable methylene group.
AID693512	Antioxidant activity assessed as inhibition of H2O2 radical scavenging activity at 50 ug/mL by spectrophotometric analysis relative to control	2012	European journal of medicinal chemistry, Dec, Volume: 58	Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d]pyrimidine derivatives.
AID449328	Antioxidant activity assessed as DPPH radical scavenging activity by UV-visible spectrophotometry	2009	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18	Synthesis and biological evaluation of quinic acid derivatives as anti-inflammatory agents.
AID682620	Antioxidant activity assessed as ABTS free radical scavenging activity at 1 mg/mL by spectroscopic analysis	2012	European journal of medicinal chemistry, Oct, Volume: 56	Synthesis, antitumor, cytotoxic and antioxidant evaluation of some new pyrazolotriazines attached to antipyrine moiety.
AID380423	Antioxidant activity in human HL60 cells assessed as inhibition of TPA-stimulated hydrogen peroxide induced DCFH-DA oxidation by fluorometric microplate assay	2006	Journal of natural products, Mar, Volume: 69, Issue:3	Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans.
AID1743179	Antioxidant activity assessed as AAPH scavenging activity by measuring residual fluorescence at 50 uM measured at 1 min interval for 30 mins by ORAC fluorescein assay relative to control	2020	European journal of medicinal chemistry, Dec-15, Volume: 208	Multiple biological active 4-aminopyrazoles containing trifluoromethyl and their 4-nitroso-precursors: Synthesis and evaluation.
AID719016	Antioxidant activity of compound assessed as DPPH radical scavenging activity	2012	Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24	Novel coumarin derivatives bearing N-benzyl pyridinium moiety: potent and dual binding site acetylcholinesterase inhibitors.
AID405699	Inhibition of lipid peroxidation in renal failured rat plasma assessed as inhibition of malondialdehyde level by TBARS assay	2008	Journal of natural products, Jun, Volume: 71, Issue:6	Antioxidant 2-phenylbenzofurans and a coumestan from Lespedeza virgata.
AID1753662	Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins under dark condition relative to vitamin C	2021	European journal of medicinal chemistry, Jun-05, Volume: 218	New organoselenides (NSAIDs-Se derivatives) as potential anticancer agents: Synthesis, biological evaluation and in silico calculations.
AID615466	Antioxidant activity assessed as inhibition of lipid peroxidation using egg lecithin liposomes incubated for 1 hr	2011	European journal of medicinal chemistry, May, Volume: 46, Issue:5	Novel dihydropyrimidines and its pyrazole derivatives: synthesis and pharmacological screening.
AID36970	Inhibition of fungal alpha-amylase	1998	Bioorganic & medicinal chemistry letters, Jul-07, Volume: 8, Issue:13	Ascorbic acid-based inhibitors of alpha-amylases.
AID1167300	Antioxidant activity assessed as DPPH radical scavenging activity incubated at room temperature for 20 mins by UV-visible spectrophotometry	2014	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21	Design, synthesis and exploring the quantitative structure-activity relationship of some antioxidant flavonoid analogues.
AID1773259	Antioxidant activity assessed as DPPH radical scavenging activity at 100 uM incubated for 2 hrs by microplate reader method	2021	European journal of medicinal chemistry, Nov-05, Volume: 223	Novel cannabidiol-carbamate hybrids as selective BuChE inhibitors: Docking-based fragment reassembly for the development of potential therapeutic agents against Alzheimer's disease.
AID1370424	Antioxidant activity assessed as DPPH radical scavenging activity incubated under dark condition for 30 mins by spectrophotometric analysis	2018	Bioorganic & medicinal chemistry letters, 02-01, Volume: 28, Issue:3	Design, synthesis and biological evaluation of glutamic acid derivatives as anti-oxidant and anti-inflammatory agents.
AID626496	Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins by spectrophotometric analysis	2011	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 21, Issue:22	Synthesis and antioxidant activities of novel 4-Schiff base-7-benzyloxy-coumarin derivatives.
AID1663502	Antioxidant activity assessed as hydroxyl radicals scavenging activity	2020	Bioorganic & medicinal chemistry letters, 08-01, Volume: 30, Issue:15	3,4-Dihydroxyphenethyl nitrate with nitric oxide releasing, antioxidant, hypoglycemic and hypolipidemic effects.
AID1505137	Antioxidant activity assessed as DPPH radical scavenging activity measured after 30 mins incubation under dark condition	2018	Journal of natural products, 01-26, Volume: 81, Issue:1	Isolation of Flavonoids and Flavonoid Glycosides from Myrsine africana and Their Inhibitory Activities against Mushroom Tyrosinase.
AID478242	Antioxidant activity in Wistar albino rat assessed as inhibition of lipid peroxidation	2010	European journal of medicinal chemistry, May, Volume: 45, Issue:5	Synthesis, spectral characterization and bioassay of 3,3'-(1,4-phenylene)-bis[2-alkoxycarbonyl-alkyl)-2-thio-benzoxa-phosphinines].
AID652744	Antioxidant activity using deaerated 1 M ethylene glycol as substrate assessed as hydroxy radical additive level at 1 mmol/L after gamma-irradiation	2012	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7	Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
AID1191657	Antioxidant activity assessed as DMPD scavenging activity after 15 mins by spectrophotometry	2015	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 25, Issue:5	Schiff's bases of quinazolinone derivatives: Synthesis and SAR studies of a novel series of potential anti-inflammatory and antioxidants.
AID1635492	Antioxidant activity assessed as DPPH free radical scavenging activity at 10 uM after 30 secs by spectrophotometry	2016	Journal of medicinal chemistry, 06-23, Volume: 59, Issue:12	Benzylpiperidine-Linked Diarylthiazoles as Potential Anti-Alzheimer's Agents: Synthesis and Biological Evaluation.
AID349359	Antioxidant activity assessed as inhibition of ROS-induced linoleic acid peroxidation at 1 mM after 15 mins at 100 degC by modified TBARS assay relative to control	2008	Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19	Antioxidative and thrombolytic TMP nitrone for treatment of ischemic stroke.
AID1743660	Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins under dark condition relative to control	2020	European journal of medicinal chemistry, Dec-15, Volume: 208	Synthesis and biological evaluation of organoselenium (NSAIDs-SeCN and SeCF
AID720998	Antioxidant activity assessed as superoxide anion radical scavenging activity after 5 mins by spectrophotometry	2013	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1	Synthesis and antioxidant activities of 2-oxo-quinoline-3-carbaldehyde Schiff-base derivatives.
AID439060	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins	2009	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 19, Issue:21	Glucose-containing flavones--their synthesis and antioxidant and neuroprotective activities.
AID36971	The compound was tested for inhibition of malt Alpha-amylase by Megazyme assay	2000	Bioorganic & medicinal chemistry letters, Jul-17, Volume: 10, Issue:14	Kinetic characterisation of ene-diol-based inhibitors of alpha-amylase.
AID1512368	Antioxidant activity assessed as DPPH radical scavenging activity at 10 uM after 30 mins under dark condition relative to control	2019	ACS medicinal chemistry letters, Oct-10, Volume: 10, Issue:10	Chalcone-Thiazole Hybrids: Rational Design, Synthesis, and Lead Identification against 5-Lipoxygenase.
AID447535	Antioxidant activity assessed as DPPH free radical scavenging activity by UV spectroscopic method	2009	Bioorganic & medicinal chemistry, Jul-15, Volume: 17, Issue:14	Synthesis, antioxidant properties and radioprotective effects of new benzothiazoles and thiadiazoles.
AID1193499	Thermodynamic equilibrium solubility, log S of the compound simulated intestinal fluid at pH 6.8 at RT after 24 hrs by shake-flask method	2015	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7	Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery.
AID693511	Antioxidant activity assessed as inhibition of H2O2 radical scavenging activity at 25 ug/mL by spectrophotometric analysis relative to control	2012	European journal of medicinal chemistry, Dec, Volume: 58	Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d]pyrimidine derivatives.
AID1462745	Antioxidant activity assessed as DPPH free radical scavenging activity by measuring radical-scavenging activity factor (moles of radicals scavenged by each mol of antioxidant) at 20 uM measured at 10 mins by HPLC	2017	Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20	Structural evidence for the DPPH radical-scavenging mechanism of 2-O-α-d-glucopyranosyl-l-ascorbic acid.
AID1867445	Induction of ROS generation in fluconazole resistant Candida glabrata 109 overexpressing CgCdr1p transporter assessed as increase in ROS level incubated for 90 mins by DCFH-DA dye based fluorescence assay	2022	Bioorganic & medicinal chemistry, 06-01, Volume: 63	Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID761704	Antioxidant activity assessed as ABTS free radical scavenging activity by spectrophotometry	2013	European journal of medicinal chemistry, Aug, Volume: 66	Selective cytotoxic effects on human breast carcinoma of new methoxylated flavonoids from Euryops arabicus grown in Saudi Arabia.
AID496825	Antimicrobial activity against Leishmania mexicana	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
AID771143	Antioxidant activity assessed as reduction of K3FeCN6 by spectrophotometric analysis in presence of FeCl3	2013	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 23, Issue:19	Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs).
AID1368752	Antioxidant activity assessed as DPPH radical scavenging activity at 10 uM by spectrphotomery	2018	Bioorganic & medicinal chemistry letters, 01-15, Volume: 28, Issue:2	Protective effects of 6-ureido/thioureido-2,4,5-trimethylpyridin-3-ols against 4-hydroxynonenal-induced cell death in adult retinal pigment epithelial-19 cells.
AID1575199	Antioxidant activity assessed as ABTS radical scavenging activity at 20 uM measured at 30 sec interval over 60 mins	2019	Bioorganic & medicinal chemistry letters, 02-01, Volume: 29, Issue:3	Aegeline, a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast.
AID652736	Antioxidant activity using deaerated ethanol as substrate assessed as 2,3-butanediol level at 1 mmol/L after gamma-irradiation by gas chromatography (Rvb = 2.05 +/- 0.09 10'7 mol/J)	2012	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7	Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
AID666938	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by spectrophotometry	2012	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13	Evaluation of novel antioxidant triterpenoid saponins from the halophyte Salicornia herbacea.
AID588210	Human drug-induced liver injury (DILI) modelling dataset from Ekins et al	2010	Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 38, Issue:12	A predictive ligand-based Bayesian model for human drug-induced liver injury.
AID1730968	Antioxidant activity assessed as hydrogen peroxide radical scavenging activity at 100 ug/ml (Rvb = 23.6 to 43.1 %)	2021	Bioorganic & medicinal chemistry letters, 03-15, Volume: 36	Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme.
AID614099	Antioxidant activity assessed as H2O2 scavenging activity at 12.5 to 250 ug/mL after 30 mins by spectrophotometric analysisic analysis	2011	Bioorganic & medicinal chemistry, Sep-01, Volume: 19, Issue:17	Tylosema esculentum extractives and their bioactivity.
AID598649	Anti-lipid peroxidation activity ferric chloride-induced lipid peroxidation using egg yolk homogenate at 40 ug/ml by TBARS assay	2011	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12	Synthesis and evaluation of antioxidant and antibacterial activities of new substituted bis(1,3,4-oxadiazoles), 3,5-bis(substituted) pyrazoles and isoxazoles.
AID1405919	Antioxidant activity assessed as inhibition of DPPH radical at 100 ug/ml relative to control	2018	European journal of medicinal chemistry, Aug-05, Volume: 156	Current progress on antioxidants incorporating the pyrazole core.
AID1596151	Antioxidant activity assessed as DPPH radical scavenging activity incubated for 15 mins under dark condition by spectrophotometric method	2019	European journal of medicinal chemistry, Jul-15, Volume: 174	A combinatorial approach for the discovery of drug-like inhibitors of 15-lipoxygenase-1.
AID360503	Antioxidant activity assessed as DPPH radical scavenging activity	1995	Journal of natural products, Nov, Volume: 58, Issue:11	Santolindiacetylene, a polyacetylene derivative isolated from the essential oil of Santolina canescens.
AID1768735	Selectivity index, ratio of IC50 for electric eel AChE to IC50 for equine serum BuChE	2021	Bioorganic & medicinal chemistry letters, 10-01, Volume: 49	Design, synthesis and biological evaluation of naringenin carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
AID693514	Antioxidant activity assessed as inhibition of H2O2 radical scavenging activity at 100 ug/mL by spectrophotometric analysis relative to control	2012	European journal of medicinal chemistry, Dec, Volume: 58	Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d]pyrimidine derivatives.
AID1549513	Antioxidant activity assessed as ABTS radical scavenging activity by spectrophotometric method relative to ascorbic acid	2019	European journal of medicinal chemistry, May-01, Volume: 169	Anticancer activity, dual prooxidant/antioxidant effect and apoptosis induction profile of new bichalcophene-5-carboxamidines.
AID693508	Antioxidant activity assessed as inhibition of nitric oxide free radical production at 75 ug/mL after 150 mins by Griess method relative to control	2012	European journal of medicinal chemistry, Dec, Volume: 58	Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d]pyrimidine derivatives.
AID733738	Antioxidant activity assessed as DPPH free radical scavenging activity after 15 mins by spectrophotometric analysis	2013	European journal of medicinal chemistry, Apr, Volume: 62	Synthesis, anticancer and antioxidant activities of 2,4,5-trimethoxy chalcones and analogues from asaronaldehyde: structure-activity relationship.
AID1589004	Antioxidant activity assessed as DPPH-radical scavenging activity at 1 mM incubated for 30 mins under dark condition by microplate reader based assay relative to control	2019	Bioorganic & medicinal chemistry, 09-01, Volume: 27, Issue:17	Inhibitory effects of N-(acryloyl)benzamide derivatives on tyrosinase and melanogenesis.
AID1567596	Antioxidant activity in human blood assessed as total antioxidant capacity at 10 uM after 48 hrs (Rvb = 6.3 +/- 0.5 No_unit)	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Carvacrol prodrugs as novel antimicrobial agents.
AID1326483	Antioxidant activity assessed as DPPH radical scavenging activity at 1 uM after 30 mins in absence of light by spectrophotometric analysis	2016	European journal of medicinal chemistry, Oct-21, Volume: 122	Combinatorial synthesis, in silico, molecular and biochemical studies of tetrazole-derived organic selenides with increased selectivity against hepatocellular carcinoma.
AID427307	Antioxidant activity assessed as DPPH radical scavenging activity by spectrophotometry	2009	Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13	Cytotoxic activity and inhibitory effect on nitric oxide production of triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae).
AID1533605	Inhibition of Electric eel AChE using acetylthiocholine iodide as substrate after 10 mins measured for every mins by Ellman's method	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Design and development of some phenyl benzoxazole derivatives as a potent acetylcholinesterase inhibitor with antioxidant property to enhance learning and memory.
AID1730959	Antioxidant activity assessed as DPPH radical scavenging activity at 75 ug/ml (Rvb = 22 to 40.2 %)	2021	Bioorganic & medicinal chemistry letters, 03-15, Volume: 36	Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme.
AID598279	Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins	2011	European journal of medicinal chemistry, May, Volume: 46, Issue:5	Synthesis of chromone carboxamide derivatives with antioxidative and calpain inhibitory properties.
AID1366175	Antioxidant activity assessed as DPPH free radical scavenging activity at 150 ug/ml after 30 mins by spectrophotometric analysis	2017	Bioorganic & medicinal chemistry, 11-01, Volume: 25, Issue:21	Design and synthesis of benzimidazole-based Rho kinase inhibitors for the treatment of glaucoma.
AID1610140	Cytotoxicity against human HFF cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Dec-15, Volume: 184	Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives.
AID761965	Antioxidant activity assessed as inhibition of lipid peroxidation activity after 15 mins by MDA assay	2013	European journal of medicinal chemistry, Aug, Volume: 66	Novel 2-(2,4-dioxo-1,3-thiazolidin-5-yl)acetamides as antioxidant and/or anti-inflammatory compounds.
AID1565347	Antioxidant activity assessed as DPPH radical scavenging activity at 10 uM/ml incubated for 20 mins by spectrophotometric method relative to control	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Cyclic enaminone as new chemotype for selective cyclooxygenase-2 inhibitory, anti-inflammatory, and analgesic activities.
AID1155573	Inhibition of human recombinant 5-LO expressed in Escherichia coli Bl21 (DE3) using arachidonic acid as substrate preincubated for 10 mins measured after 10 mins by RP-HPLC analysis	2014	Journal of medicinal chemistry, Jul-10, Volume: 57, Issue:13	SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
AID448094	Antimicrobial activity against Staphylococcus aureus NCIM 5021 after 24 hrs by disk diffusion method	2009	European journal of medicinal chemistry, Nov, Volume: 44, Issue:11	Antioxidant and antibacterial studies of arylazopyrazoles and arylhydrazonopyrazolones containing coumarin moiety.
AID1487491	Antioxidant activity assessed as H2O2 free radical scavenging activity at 100 ug/ml after 10 to 15 mins by spectrophotometric analysis	2017	Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16	Synthesis, antioxidant, antifungal, molecular docking and ADMET studies of some thiazolyl hydrazones.
AID1565349	Antioxidant activity assessed as DPPH radical scavenging activity at 40 uM/ml incubated for 20 mins by spectrophotometric method relative to control	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Cyclic enaminone as new chemotype for selective cyclooxygenase-2 inhibitory, anti-inflammatory, and analgesic activities.
AID1899549	Antioxidant activity assessed as DPPH radical scavenging activity at 20 uM incubated for 30 mins under dark condition by microplate reader based assay	2022	European journal of medicinal chemistry, Jan-15, Volume: 228	Imidazolylacetophenone oxime-based multifunctional neuroprotective agents: Discovery and structure-activity relationships.
AID1399482	Inhibition of equine serum BChE using butylthiocholine iodide as substrate incubated for 10 mins followed by substrate addition by Ellman's method	2018	Bioorganic & medicinal chemistry, 09-01, Volume: 26, Issue:16	Synthesis, molecular docking, and biological activity of 2-vinyl chromones: Toward selective butyrylcholinesterase inhibitors for potential Alzheimer's disease therapeutics.
AID693501	Antioxidant activity assessed as inhibition of DPPH free radical production at 25 ug/mL after 30 mins by spectrophotometric analysis relative to control	2012	European journal of medicinal chemistry, Dec, Volume: 58	Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d]pyrimidine derivatives.
AID1730967	Antioxidant activity assessed as hydrogen peroxide radical scavenging activity at 75 ug/ml (Rvb = 23.6 to 43.1 %)	2021	Bioorganic & medicinal chemistry letters, 03-15, Volume: 36	Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme.
AID1248400	Inhibition of malt alpha-amylase	2015	Bioorganic & medicinal chemistry, Oct-15, Volume: 23, Issue:20	From carbohydrates to drug-like fragments: Rational development of novel α-amylase inhibitors.
AID1453055	Antioxidant activity assessed as inhibition of DPPH radical generation at 0.04 mg/ml after 20 mins under dark condition by UV-Visible spectrophotometric analysis relative to control	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Synthesis, characterization, molecular docking and in vitro antimalarial properties of new carboxamides bearing sulphonamide.
AID1126577	Antioxidant activity assessed as trolox equivalents of cupric reducing antioxidant capacity after 30 mins	2014	European journal of medicinal chemistry, May-06, Volume: 78	Synthesis and biological evaluation of N-dehydrodipeptidyl-N,N'-dicyclohexylurea analogs.
AID506733	Activity of HIF prolyl hydroxylase-3	2007	Nature chemical biology, Mar, Volume: 3, Issue:3	Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one?
AID744460	Antioxidant activity of the compound assessed as DPPH free radical scavenging activity at 312.5 uM after 60 mins by spectrophotometric analysis relative to control	2013	European journal of medicinal chemistry, May, Volume: 63	Synthesis and biological activities of some novel aminomethyl derivatives of 4-substituted-5-(2-thienyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones.
AID449287	Antioxidant activity assessed as DPPH radical scavenging activity at 50 uM after 30 mins by spectrophotometry	2009	Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23	Design, synthesis, and examination of neuron protective properties of alkenylated and amidated dehydro-silybin derivatives.
AID1875639	Immunomodulatory activity in IL-17A Katushka/IL-10eGFP/Foxp3RFP reporter mouse cell trace violet-labelled CD4+ T cell derived TGF-beta1/IL-6/IL-23-polarized Th17 cells assessed as increase in IL-17 positive cell population at 5 to 20 uM measured after 3 d	2022	Journal of natural products, 11-25, Volume: 85, Issue:11	Cellular Stress-Induced Metabolites in
AID1610412	Inhibition of mushroom tyrosinase using L-dopa as substrate by spectrophotometric method	2019	European journal of medicinal chemistry, Dec-15, Volume: 184	Benzo[b]thiophene-thiazoles as potent anti-Toxoplasma gondii agents: Design, synthesis, tyrosinase/tyrosine hydroxylase inhibitors, molecular docking study, and antioxidant activity.
AID1487482	Antioxidant activity assessed as DPPH free radical scavenging activity at 40 ug/ml after 15 mins by spectrophotometric method	2017	Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16	Synthesis, antioxidant, antifungal, molecular docking and ADMET studies of some thiazolyl hydrazones.
AID506731	Activity of HIF prolyl hydroxylase-1	2007	Nature chemical biology, Mar, Volume: 3, Issue:3	Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one?
AID674915	Antioxidant activity assessed as DPPH scavenging activity after 30 mins by microplate reader method	2012	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17	The antioxidant effect of imine resveratrol analogues.
AID1503706	Antioxidant activity assessed as H2O2 free radical scavenging activity after 1 hr by UV spectrophotometric analysis	2017	European journal of medicinal chemistry, Dec-01, Volume: 141	Therapeutic investigations of novel indoxyl-based indolines: A drug target validation and Structure-Activity Relationship of angiotensin-converting enzyme inhibitors with cardiovascular regulation and thrombolytic potential.
AID1565351	Antioxidant activity assessed as DPPH radical scavenging activity at 80 uM/ml incubated for 20 mins by spectrophotometric method relative to control	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Cyclic enaminone as new chemotype for selective cyclooxygenase-2 inhibitory, anti-inflammatory, and analgesic activities.
AID1377035	Antioxidant activity assessed as DPPH radical scavenging activity at test compound/DPPH volume ratio 1:1 after 1 hr by UV-spectrophotometric method	2017	Journal of natural products, 06-23, Volume: 80, Issue:6	Derivatives of the Lignan 7'-Hydroxymatairesinol with Antioxidant Properties and Enhanced Lipophilicity.
AID1277565	Antioxidant activity assessed as suppression of H2O2/cobalt2+-mediated hydroxyl radical formation by luminol-based fluorescence assay	2016	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 26, Issue:4	Synthesis and biological evaluation of novel orally available 1-phenyl-6-aminouracils containing dimethyldihydrobenzofuranol structure for the treatment of allergic skin diseases.
AID724080	Antioxidant activity assessed as hydroxyl radical scavenging activity at 100 uM after 5 mins	2013	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 23, Issue:3	Design, synthesis, characterization and biological evaluation of novel pyrazole integrated benzophenones.
AID588209	Literature-mined public compounds from Greene et al multi-species hepatotoxicity modelling dataset	2010	Chemical research in toxicology, Jul-19, Volume: 23, Issue:7	Developing structure-activity relationships for the prediction of hepatotoxicity.
AID1501903	Antioxidant activity assessed as redox reaction between compound and MTT in DMSO measured after 6 hrs	2017	Journal of natural products, 09-22, Volume: 80, Issue:9	Lipid Peroxidation and Cyclooxygenase Enzyme Inhibitory Compounds from Prangos haussknechtii.
AID491004	Antioxidant activity assessed as inhibition of nitric oxide production at 100 uM	2010	European journal of medicinal chemistry, Jul, Volume: 45, Issue:7	Synthesis and bioassay of pyrrolyl oxazolines and thiazolines.
AID1453457	Antioxidant activity of the compound in phosphate buffer at pH 6.6 assessed as potassium ferric cyanide ion reducing activity at 1 umol/ml after 20 mins by spectrophotometric method relative to control	2017	Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13	Synthesis of methanesulphonamido-benzimidazole derivatives as gastro-sparing antiinflammatory agents with antioxidant effect.
AID1871454	Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins in dark condition by spectrophotometrical analysis	2022	European journal of medicinal chemistry, Jan-05, Volume: 227	Coumarin-benzimidazole hybrids: A review of developments in medicinal chemistry.
AID295621	DPPH radical scavenging activity at 200 ppm	2007	Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11	Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit.
AID179357	Effect of AOS scavenger on arrhythmias induced by ischemia-reperfusion in anesthetized rat measured as ventricular tachycardia (VT), frequency, times at 3 mg/kg	1988	Journal of medicinal chemistry, Apr, Volume: 31, Issue:4	Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID497110	Antioxidant activity assessed as ABTS free radical scavenging activity at 100 uM after 12 hrs	2010	Bioorganic & medicinal chemistry, Aug-01, Volume: 18, Issue:15	Synthesis and biological evaluation of arylidene analogues of Meldrum's acid as a new class of antimalarial and antioxidant agents.
AID693503	Antioxidant activity assessed as inhibition of DPPH free radical production at 75 ug/mL after 30 mins by spectrophotometric analysis relative to control	2012	European journal of medicinal chemistry, Dec, Volume: 58	Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d]pyrimidine derivatives.
AID429185	Antioxidant activity assessed as radical DPPH scavenging activity	2009	Bioorganic & medicinal chemistry, Aug-01, Volume: 17, Issue:15	Inhibitory effects of flavonoids isolated from Fragaria ananassa Duch on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3.
AID652727	Selectivity ratio of MNTD for human RD cells to EC50 for HSV1	2012	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7	Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
AID1155648	Neuroprotective activity against amyloid beta (25 to 35)-induced cell death in human SH-SY5Y cells assessed as cell viability at 0.4 uM after 24 hrs by MTT assay relative to control	2014	Journal of natural products, Jun-27, Volume: 77, Issue:6	Lignans from the fruit of Schisandra glaucescens with antioxidant and neuroprotective properties.
AID1810884	Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins by spectrophotometric analysis
AID1370494	Antioxidant activity assessed as DPPH radical scavenging activity after 20 to 30 mins	2018	Bioorganic & medicinal chemistry letters, 02-01, Volume: 28, Issue:3	Microwave-assisted synthesis of novel 5-substituted benzylidene amino-2-butyl benzofuran-3-yl-4-methoxyphenyl methanones as antileishmanial and antioxidant agents.
AID1385540	Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins in dark condition	2018	Journal of natural products, 08-24, Volume: 81, Issue:8	Spiro-Phthalides and Isocoumarins Isolated from the Marine-Sponge-Derived Fungus Setosphaeria sp. SCSIO41009.
AID327008	DPPH radical scavenging activity	2008	Journal of natural products, Jan, Volume: 71, Issue:1	Gentisyl alcohol derivatives from the marine-derived fungus Penicillium terrestre.
AID733736	Antioxidant activity assessed as nitric oxide scavenging activity after 2.5 hrs by Griess assay	2013	European journal of medicinal chemistry, Apr, Volume: 62	Synthesis, anticancer and antioxidant activities of 2,4,5-trimethoxy chalcones and analogues from asaronaldehyde: structure-activity relationship.
AID1264277	Antioxidant activity assessed as DPPH free radical scavenging activity at 100 ug/ml after 30 mins by spectrophotometric assay	2015	European journal of medicinal chemistry, Nov-02, Volume: 104	Synthesis and pharmacological evaluation of some new fluorine containing hydroxypyrazolines as potential anticancer and antioxidant agents.
AID1851303	Antioxidant activity assessed as DPPH radical scavenging activity by absorbance based analysis	2022	Bioorganic & medicinal chemistry, 09-15, Volume: 70	Anti-inflammatory and anticancer p-terphenyl derivatives from fungi of the genus Thelephora.
AID1867443	Induction of ROS generation in fluconazole resistant Saccharomyces cerevisiae overexpressing CgCdr1p transporter assessed as increase in ROS level incubated for 90 mins by DCFH-DA dye based fluorescence assay	2022	Bioorganic & medicinal chemistry, 06-01, Volume: 63	Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata.
AID1428664	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by spectrophotometric method	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Novel flavonolignan hybrid antioxidants: From enzymatic preparation to molecular rationalization.
AID652740	Antioxidant activity using deaerated 1 M ethanol as substrate assessed as hydroxy radical additive level at 1 mmol/L after gamma-irradiation	2012	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7	Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
AID1169847	Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins	2014	Journal of natural products, Nov-26, Volume: 77, Issue:11	Chlorinated polyketide obtained from a Daldinia sp. treated with the epigenetic modifier suberoylanilide hydroxamic acid.
AID598280	Antioxidant activity in rat liver homogenates assessed as inhibition of iron-ascorbic acid mix-induced lipid peroxidation after 30 mins by TBARS assay	2011	European journal of medicinal chemistry, May, Volume: 46, Issue:5	Synthesis of chromone carboxamide derivatives with antioxidative and calpain inhibitory properties.
AID1360871	Antioxidant activity assessed as ferric ion reduction by measuring FeSO4 equivalents reducing Fe3+-TPTZ to Fe2+-TPTZ at 10 ug/ml after 25 mins by FRAP assay	2018	European journal of medicinal chemistry, Jul-15, Volume: 155	Synthesis and biological evaluation of new coumarins bearing 2,4-diaminothiazole-5-carbonyl moiety.
AID1439804	Antioxidant activity assessed as DPPH radical scavenging activity after 20 mins by UV/VIS Spectrophotometric method	2017	Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7	Biologically active perspective synthesis of heteroannulated 8-nitroquinolines with green chemistry approach.
AID1178159	Antioxidant activity of the compound assessed as reduction in absorbance of DPPH after 60 mins incubation at 35 uM by DPPH radical scavenging /microplate assay	2014	Bioorganic & medicinal chemistry, May-01, Volume: 22, Issue:9	Synthesis, antioxidant and photoprotection activities of hybrid derivatives useful to prevent skin cancer.
AID652733	Antioxidant activity using 1M ethanol as substrate assessed as H2O2 level at 1 mmol/L after gamma-irradiation by spectrophotometry (Rvb = 2.73 +/- 0.18 10'7 mol/J)	2012	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7	Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
AID502055	Antioxidant activity assessed as DPPH radical scavenging activity at 100 ug/ml	2010	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17	InCl3 mediated one-pot multicomponent synthesis, anti-microbial, antioxidant and anticancer evaluation of 3-pyranyl indole derivatives.
AID1428668	Antioxidant activity against tert-butyl hydroperoxide-induced lipoperoxidation in rat liver microsomal membranes at 50 uM preincubated for 10 mins followed by tert-butyl hydroperoxide addition measured after 60 mins by TBARS assay relative to control	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Novel flavonolignan hybrid antioxidants: From enzymatic preparation to molecular rationalization.
AID619975	Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins by spectrophotometric analysis	2011	European journal of medicinal chemistry, Oct, Volume: 46, Issue:10	Synthesis and antioxidant activity of oxazolyl/thiazolylsulfonylmethyl pyrazoles and isoxazoles.
AID309192	DPPH radical scavenging activity after 30 mins	2007	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 17, Issue:19	Synthetic tyrosyl gallate derivatives as potent melanin formation inhibitors.
AID1248049	Antioxidant activity assessed as inhibition of AAPH-induced lipid peroxidation after 3 hrs by TBA-MDA test	2015	Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19	Synthesis, electronic properties, antioxidant and antibacterial activity of some new benzimidazoles.
AID374240	Antioxidant activity in Sprague-Dawley rat erythrocytes assessed as ABTS-induced hemolysis after 1 hr	2009	European journal of medicinal chemistry, Apr, Volume: 44, Issue:4	New acyclic nucleosides analogues as potential analgesic, anti-inflammatory, anti-oxidant and anti-microbial derived from pyrimido[4,5-b]quinolines.
AID598648	Antioxidant activity assessed as DPPH radical scavenging activity at 10 ug/ml by UV-visible spectrophotometry	2011	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12	Synthesis and evaluation of antioxidant and antibacterial activities of new substituted bis(1,3,4-oxadiazoles), 3,5-bis(substituted) pyrazoles and isoxazoles.
AID1155577	Aqueous stability of the compound in at 2 uM in 10 mM aqueous ammonium bicarbonate at pH 7.9 assessed as formation of trans-6-(4'-hydroxy-3'-methoxyphenyl)-2,4-dioxo-5-hexenal measured as residual amount of compound by reversed phase liquid chromatography	2014	Journal of medicinal chemistry, Jul-10, Volume: 57, Issue:13	SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
AID1405936	Antioxidant activity assessed as ABTS radical scavenging activity	2018	European journal of medicinal chemistry, Aug-05, Volume: 156	Current progress on antioxidants incorporating the pyrazole core.
AID1464784	Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins under dark condition by UV-vis spectrophotometric method	2017	Bioorganic & medicinal chemistry letters, 10-15, Volume: 27, Issue:20	Design, synthesis and biological evaluation of 8-substituted-6-hydrazonoindolo[2,1-b]quinazolin-12(6H)-one scaffolds as potential cytotoxic agents: IDO-1 targeting molecular docking studies.
AID351092	Antioxidant activity against FeSO4-induced lipid peroxidation in rat liver homogenate assessed as inhibition of malondialdehyde release after 1 hr by thiobarbituric acid assay	2009	Bioorganic & medicinal chemistry, May-01, Volume: 17, Issue:9	Preparation of two sets of 5,6,7-trioxygenated dihydroflavonol derivatives as free radical scavengers and neuronal cell protectors to oxidative damage.
AID1882616	Inhibition of jack bean urease	2022	European journal of medicinal chemistry, Apr-15, Volume: 234	An overview on the synthetic urease inhibitors with structure-activity relationship and molecular docking.
AID1762405	Inhibition of equine serum BuChE using butyrylcholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method	2021	European journal of medicinal chemistry, Jun-05, Volume: 218	Novel potent bifunctional carboxylesterase inhibitors based on a polyfluoroalkyl-2-imino-1,3-dione scaffold.
AID670405	Antioxidant activity assessed as DPPH free radical scavenging activity	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4',7-dihydroxyflavone and their analogues.
AID693504	Antioxidant activity assessed as inhibition of DPPH free radical production at 100 ug/mL after 30 mins by spectrophotometric analysis relative to control	2012	European journal of medicinal chemistry, Dec, Volume: 58	Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d]pyrimidine derivatives.
AID736835	Antioxidant activity assessed as DPPH free radical scavenging activity at 20 uM	2013	Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3	Structure-activity relationship study of vitamin k derivatives yields highly potent neuroprotective agents.
AID447537	Antioxidant activity assessed as ABTS free radical scavenging activity by radical cation discoloration assay	2009	Bioorganic & medicinal chemistry, Jul-15, Volume: 17, Issue:14	Synthesis, antioxidant properties and radioprotective effects of new benzothiazoles and thiadiazoles.
AID351090	Antioxidant activity assessed as superoxide radical scavenging activity by spectrophotometry	2009	Bioorganic & medicinal chemistry, May-01, Volume: 17, Issue:9	Preparation of two sets of 5,6,7-trioxygenated dihydroflavonol derivatives as free radical scavengers and neuronal cell protectors to oxidative damage.
AID619978	Antioxidant activity assessed as nitric oxide scavenging activity at 100 ug/ml after 150 mins by Griess method relative to control	2011	European journal of medicinal chemistry, Oct, Volume: 46, Issue:10	Synthesis and antioxidant activity of oxazolyl/thiazolylsulfonylmethyl pyrazoles and isoxazoles.
AID1858994	Antioxidant activity assessed as DPPH radical scavenging activity	2022	European journal of medicinal chemistry, Jan-05, Volume: 227	Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids.
AID1366174	Antioxidant activity assessed as DPPH free radical scavenging activity at 100 ug/ml after 30 mins by spectrophotometric analysis	2017	Bioorganic & medicinal chemistry, 11-01, Volume: 25, Issue:21	Design and synthesis of benzimidazole-based Rho kinase inhibitors for the treatment of glaucoma.
AID670408	Antioxidant activity in erythrocytes assessed as inhibition of hemolysis	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4',7-dihydroxyflavone and their analogues.
AID754977	Inhibition of human leukocyte 5-LOX pseudoperoxidase activity assessed as reduction of active ferric ion to inactive ferrous state measured decomposition of 13-(S)-HPODE at 40 uM after 30 mins by iron-xylenol orange staining assay	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Pseudoperoxidase investigations of hydroperoxides and inhibitors with human lipoxygenases.
AID754974	Inhibition of N-terminal His6-tagged human prostate epithelial 15-LOX2 pseudoperoxidase activity assessed as reduction of active ferric ion to inactive ferrous state measured decomposition of 13-(S)-HPODE at 40 uM after 30 mins by iron-xylenol orange stai	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Pseudoperoxidase investigations of hydroperoxides and inhibitors with human lipoxygenases.
AID678493	Antioxidant activity assessed as DPPH radical scavenging activity at 100 uM after 20 mins by spectrophotometry	2012	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18	Synthesis, biological evaluation, and docking studies of 3-(substituted)-aryl-5-(9-methyl-3-carbazole)-1H-2-pyrazolines as potent anti-inflammatory and antioxidant agents.
AID1585457	Antioxidant activity assessed as DPPH free radical scavenging activity after 10 mins	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Dimeric cinnamoylamide analogues for regulation of tyrosinase activity in melanoma cells: A role of diamide-link chain length.
AID1497073	Antiglycation activity in bovine serum albumin assessed as inhibition of advanced glycated end product formation after 24 hrs in presence of alpha-D-glucose by fluorescence assay	2018	Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12	Antidiabetic potential of phytochemicals isolated from the stem bark of Myristica fatua Houtt. var. magnifica (Bedd.) Sinclair.
AID502061	Antioxidant activity assessed as ABTS radical scavenging activity at 200 ug/ml	2010	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17	InCl3 mediated one-pot multicomponent synthesis, anti-microbial, antioxidant and anticancer evaluation of 3-pyranyl indole derivatives.
AID437950	Antioxidant activity in Wistar rat brain assessed as catalase content	2010	European journal of medicinal chemistry, Jan, Volume: 45, Issue:1	Synthesis, spectral characterization and biological evaluation of phosphorylated derivatives of galanthamine.
AID1430035	Antioxidant activity assessed as DDQ radical scavenging activity by spectrophotometric method relative to control	2017	Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5	Synthesis of new chromeno-carbamodithioate derivatives and preliminary evaluation of their antioxidant activity and molecular docking studies.
AID16878	The reaction rate constant(K) by measuring competition with nitroblue tetrazolium of the superoxide radicals formed by xanthine oxidase/xanthine	1995	Journal of medicinal chemistry, Jul-21, Volume: 38, Issue:15	Cardioselective ammonium, phosphonium, and sulfonium analogues of alpha-tocopherol and ascorbic acid that inhibit in vitro and ex vivo lipid peroxidation and scavenge superoxide radicals.
AID1875640	Immunomodulatory activity in IL-17A Katushka/IL-10eGFP/Foxp3RFP reporter mouse cell trace violet-labelled CD4+ T cell derived TGF-beta1/IL-6/IL-23-polarized Th17 cells assessed as increase in IL-10/IL-17 positive cell population at 5 to 20 uM measured aft	2022	Journal of natural products, 11-25, Volume: 85, Issue:11	Cellular Stress-Induced Metabolites in
AID486892	Antioxidant activity assessed as DPPH radical scavenging activity after 8 hrs	2010	Journal of natural products, Jun-25, Volume: 73, Issue:6	Dihydro-beta-agarofuran sesquiterpenes and pentacyclic triterpenoids from the root bark of Osyris lanceolata.
AID375989	Antioxidant activity assessed as superoxide anion scavenging activity by xanthine oxidase oxidation system relative to control	2006	Journal of natural products, Apr, Volume: 69, Issue:4	Vanillic acid glycoside and quinic acid derivatives from Gardeniae Fructus.
AID592649	Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins	2011	Bioorganic & medicinal chemistry, Apr-01, Volume: 19, Issue:7	Synthesis and anti-melanogenic activity of hydroxyphenyl benzyl ether analogues.
AID292585	DPPH radical scavenging activity at 25 uM	2007	Journal of natural products, Jul, Volume: 70, Issue:7	Kadsuphilols A-H, oxygenated lignans from Kadsura philippinensis.
AID1810880	Inhibition of human BChE using butyrylthiocholine iodide as substrate incubated for 20 mins followed by substrate addition by Ellman's method
AID36969	Inhibition of Alpha-amylase	1998	Bioorganic & medicinal chemistry letters, Jul-07, Volume: 8, Issue:13	Ascorbic acid-based inhibitors of alpha-amylases.
AID1610139	Antiproliferative activity against human SW620 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Dec-15, Volume: 184	Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives.
AID614063	Inhibition of bovine testes hyaluronidase at 80 uM after 30 mins at pH 5 by turbidimetric analysis	2011	European journal of medicinal chemistry, Sep, Volume: 46, Issue:9	Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase.
AID442292	Antioxidant activity assessed as DPPH radical scavenging activity by microplate reader assay	2010	European journal of medicinal chemistry, Feb, Volume: 45, Issue:2	Synthesis, anti-HCV, antioxidant, and peroxynitrite inhibitory activity of fused benzosuberone derivatives.
AID722253	Antioxidant activity assessed as DPPH radical scavenging activity in ethanol solution at 10 ug/mL	2013	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 23, Issue:3	Synthesis and antioxidant activity of thymol and carvacrol based Schiff bases.
AID764764	Antioxidant activity assessed as DPPH radical scavenging activity at 30 uM after 30 mins	2013	Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17	Design, synthesis and pharmacological evaluation of (E)-3,4-dihydroxy styryl sulfonamides derivatives as multifunctional neuroprotective agents against oxidative and inflammatory injury.
AID652742	Antioxidant activity using deaerated 3 M ethylene glycol as substrate assessed as hydroxy radical additive level at 1 mmol/L after gamma-irradiation	2012	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7	Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
AID689838	Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins	2012	Journal of natural products, Oct-26, Volume: 75, Issue:10	Diarylcyclopentendione metabolite obtained from a Preussia typharum isolate procured using an unconventional cultivation approach.
AID1453460	Antioxidant activity of the compound in phosphate buffer at pH 6.6 assessed as potassium ferric cyanide ion reducing activity at 10 umol/ml after 20 mins by spectrophotometric method relative to control	2017	Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13	Synthesis of methanesulphonamido-benzimidazole derivatives as gastro-sparing antiinflammatory agents with antioxidant effect.
AID1313280	Antioxidant activity assessed as DPPH radical scavenging activity at 40 ug/ml after 20 mins by spectrophotometry relative to control	2016	Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15	Synthesis of lignan conjugates via cyclopropanation: Antimicrobial and antioxidant studies.
AID1743181	Antioxidant activity in human erythrocytes assessed as protection against AAPH-induced hemolysis at 400 uM preincubated for 20 mins followed by AAPH addition and measured after 2 hrs by spectrophotometric method relative to control	2020	European journal of medicinal chemistry, Dec-15, Volume: 208	Multiple biological active 4-aminopyrazoles containing trifluoromethyl and their 4-nitroso-precursors: Synthesis and evaluation.
AID670407	Antioxidant activity of the compound assessed as inhibition of lipid peroxidation	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4',7-dihydroxyflavone and their analogues.
AID497113	Antioxidant activity against DPPH free radical assessed as compound able to consume half the amount of free radical after 1 hr	2010	Bioorganic & medicinal chemistry, Aug-01, Volume: 18, Issue:15	Synthesis and biological evaluation of arylidene analogues of Meldrum's acid as a new class of antimalarial and antioxidant agents.
AID403405	Antioxidant activity in rat brain assessed as malondialdehyde level at 568 uM by thiobarbituric acid method	2005	Journal of natural products, Aug, Volume: 68, Issue:8	Neuroprotective and antioxidant activity of compounds from the aerial parts of Dioscorea opposita.
AID492088	Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins	2010	Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14	(-)-N-Formylanonaine from Michelia alba as a human tyrosinase inhibitor and antioxidant.
AID1635488	Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 40 uM after 24 hrs by MTT assay	2016	Journal of medicinal chemistry, 06-23, Volume: 59, Issue:12	Benzylpiperidine-Linked Diarylthiazoles as Potential Anti-Alzheimer's Agents: Synthesis and Biological Evaluation.
AID1377034	Lipophilicity, log P of the compound	2017	Journal of natural products, 06-23, Volume: 80, Issue:6	Derivatives of the Lignan 7'-Hydroxymatairesinol with Antioxidant Properties and Enhanced Lipophilicity.
AID767447	Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins	2013	European journal of medicinal chemistry, Sep, Volume: 67	Regioselective synthesis of phenanthrenes and evaluation of their anti-oxidant based anti-inflammatory potential.
AID1268018	Antioxidant activity assessed as DPPH free radical scavenging activity at 75 ug/ml after 20 mins by UV-vis spectrophotometry analysis	2016	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2	Synthesis of novel coumarin appended bis(formylpyrazole) derivatives: Studies on their antimicrobial and antioxidant activities.
AID722704	Antioxidant activity assessed as DPPH radical scavenging activity by spectrophotometry	2013	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1	Design, synthesis and inhibitory activities of naringenin derivatives on human colon cancer cells.
AID496821	Antimicrobial activity against Leishmania	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
AID1309171	Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins by spectrophotometry	2016	Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16	Ionophoric polyphenols selectively bind Cu(2+), display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila.
AID1250855	Inhibition of rat intestinal Sucrase using sucrose as substrate assessed as glucose release after 40 mins by glucose oxidase method	2015	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20	New arylalkanones from Horsfieldia macrobotrys, effective antidiabetic agents concomitantly inhibiting α-glucosidase and free radicals.
AID496818	Antimicrobial activity against Trypanosoma brucei brucei	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
AID1405921	Antioxidant activity assessed as DPPH radical scavenging activity relative to control	2018	European journal of medicinal chemistry, Aug-05, Volume: 156	Current progress on antioxidants incorporating the pyrazole core.
AID1506519	Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins	2017	MedChemComm, Feb-01, Volume: 8, Issue:2	Synthesis, characterization, solubilization, cytotoxicity and antioxidant activity of aminomethylated dihydroquercetin.
AID1352198	Antioxidant activity assessed as inhibition of DPPH radical formation after 30 mins	2018	European journal of medicinal chemistry, Feb-10, Volume: 145	Design, synthesis, biological evaluation and docking studies of new 3-(4,5-dihydro-1H-pyrazol/isoxazol-5-yl)-2-phenyl-1H-indole derivatives as potent antioxidants and 15-lipoxygenase inhibitors.
AID1288029	Antioxidant activity assessed as DPPH free radical scavenging activity by UV-visible spectrophotometric analysis	2016	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7	Biological evaluation and molecular docking studies of new curcuminoid derivatives: Synthesis and characterization.
AID1126575	Antioxidant activity assessed as hydroxyl radical scavenging activity after 15 mins	2014	European journal of medicinal chemistry, May-06, Volume: 78	Synthesis and biological evaluation of N-dehydrodipeptidyl-N,N'-dicyclohexylurea analogs.
AID1173788	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by spectrophotometry	2014	Bioorganic & medicinal chemistry, Dec-01, Volume: 22, Issue:23	Antioxidant and antimicrobial studies on fused-ring pyrazolones and isoxazolones.
AID1506525	Reducing power of the compound assessed as reducing Fe3+ power at 0.15 to 1.2 mM using potassium ferricyanide in pH 6.6 KH2PO4-K2HPO4 buffer by UV spectrophotometry	2017	MedChemComm, Feb-01, Volume: 8, Issue:2	Synthesis, characterization, solubilization, cytotoxicity and antioxidant activity of aminomethylated dihydroquercetin.
AID652746	Antioxidant activity using deaerated 0.1 M alpha-glycerophosphate as substrate assessed as hydroxy radical level at 1 mmol/L after gamma-irradiation	2012	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7	Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
AID548960	Antioxidant activity of the compound assessed as reducing activity of DPPH at 0.1 mM after 20 mins	2010	Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23	Does conjugation of antioxidants improve their antioxidative/anti-inflammatory potential?
AID767448	Antioxidant activity assessed as galvinoxyl free radical scavenging activity after 20 mins	2013	European journal of medicinal chemistry, Sep, Volume: 67	Regioselective synthesis of phenanthrenes and evaluation of their anti-oxidant based anti-inflammatory potential.
AID1326485	Pro-oxidant activity as bleomycin-Fe2+ induced calf thymus DNA damage measured as absorbance at 2 mM after 1 hr by thiobarbituric acid-based assay	2016	European journal of medicinal chemistry, Oct-21, Volume: 122	Combinatorial synthesis, in silico, molecular and biochemical studies of tetrazole-derived organic selenides with increased selectivity against hepatocellular carcinoma.
AID1155643	Antioxidant activity assessed as 150 uM DPPH free radical scavenging activity under dark condition after 30 mins by microplate reader analysis	2014	Journal of natural products, Jun-27, Volume: 77, Issue:6	Lignans from the fruit of Schisandra glaucescens with antioxidant and neuroprotective properties.
AID549275	Cytotoxicity against mouse B16 cells up to 100 ug/ml after 72 hrs by MTT assay	2010	Journal of natural products, Nov-29, Volume: 73, Issue:11	Inhibition of melanogenesis and oxidation by protocatechuic acid from Origanum vulgare (oregano).
AID1202778	Antioxidant activity assessed as H2O2 scavenging activity after 15 mins	2015	Journal of natural products, Feb-27, Volume: 78, Issue:2	Antioxidative compounds from Garcinia buchananii stem bark.
AID626499	Antioxidant activity assessed as hydroxyl radical scavenging activity after 1 hr by spectrophotometric analysis	2011	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 21, Issue:22	Synthesis and antioxidant activities of novel 4-Schiff base-7-benzyloxy-coumarin derivatives.
AID1382194	Antioxidant activity assessed as ferric ion reduction by measuring FeSO4 equivalents reducing Fe3+-TPTZ to Fe2+-TPTZ measured every 15 secs for 4 mins by FRAP assay	2018	European journal of medicinal chemistry, Feb-25, Volume: 146	Regioselective synthesis of 7-O-esters of the flavonolignan silibinin and SARs lead to compounds with overadditive neuroprotective effects.
AID195224	The compound was tested for the stimulation of lipid peroxidation in rat liver microsomes induced by [Fe2+] at a concentration of 10E-5 M.	1991	Journal of medicinal chemistry, Jul, Volume: 34, Issue:7	3-O-alkylascorbic acids as free-radical quenchers: synthesis and inhibitory effect on lipid peroxidation.
AID1730966	Antioxidant activity assessed as hydrogen peroxide radical scavenging activity at 50 ug/ml (Rvb = 23.6 to 43.1 %)	2021	Bioorganic & medicinal chemistry letters, 03-15, Volume: 36	Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme.
AID1784505	Antioxidant activity assessed as free radical scavenging activity incubated for 30 mins under dark condition by DPPH assay	2021	European journal of medicinal chemistry, Dec-05, Volume: 225	From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects.
AID1668231	Antioxidant activity assessed as DPPH radical scavenging activity	2020	Bioorganic & medicinal chemistry letters, 06-15, Volume: 30, Issue:12	Synthesis of novel of 2, 5-disubstituted 1, 3, 4- oxadiazole derivatives and their in vitro anti-inflammatory, anti-oxidant evaluation, and molecular docking study.
AID363319	Antioxidant activity assessed as inhibition of peroxynitrite-induced evans blue bleaching at 50 uM	2008	European journal of medicinal chemistry, Jun, Volume: 43, Issue:6	Synthesis and biological activities of a series of 4,5-diaryl-3-hydroxy-2(5H)-furanones.
AID1487481	Antioxidant activity assessed as DPPH free radical scavenging activity at 20 ug/ml after 15 mins by spectrophotometric method	2017	Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16	Synthesis, antioxidant, antifungal, molecular docking and ADMET studies of some thiazolyl hydrazones.
AID496826	Antimicrobial activity against Entamoeba histolytica	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
AID614052	Inhibition of bovine testes hyaluronidase at 49 uM after 30 mins at pH 5 by turbidimetric analysis	2011	European journal of medicinal chemistry, Sep, Volume: 46, Issue:9	Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase.
AID772993	Antioxidant activity assessed as trolox equivalents of ABTS radical scavenging activity at pH 7.4 by spectrophotometry	2013	European journal of medicinal chemistry, Oct, Volume: 68	Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles.
AID1227882	Antioxidant activity assessed as DPPH radical scavenging activity after 10 mins by spectrophotomteric analysis	2015	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 25, Issue:1	Anti-inflammatory and antitumor phenylpropanoid sucrosides from the seeds of Raphanus sativus.
AID615464	Antioxidant activity assessed as nitric oxide radical scavenging activity after 150 mins	2011	European journal of medicinal chemistry, May, Volume: 46, Issue:5	Novel dihydropyrimidines and its pyrazole derivatives: synthesis and pharmacological screening.
AID1549512	Antioxidant activity assessed as ABTS radical scavenging activity by spectrophotometric analysis relative to control	2019	European journal of medicinal chemistry, May-01, Volume: 169	Anticancer activity, dual prooxidant/antioxidant effect and apoptosis induction profile of new bichalcophene-5-carboxamidines.
AID1347860	Growth inhibition of mouse B16 cells at 25 uM after 48 hrs by SRB assay relative to control	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	Design, synthesis and evaluation of novel dihydrostilbene derivatives as potential anti-melanogenic skin-protecting agents.
AID1704055	Antioxidant activity assessed as radical scavenging activity measured after 30 mins by DPPH assay	2020	European journal of medicinal chemistry, Oct-15, Volume: 204	Synthesis, inhibitory activity and in silico docking of dual COX/5-LOX inhibitors with quinone and resorcinol core.
AID1183315	Nitric oxide scavenging activity by naphthylethylenediamine dihydrochloride based Griesse-Ilosavay method	2014	European journal of medicinal chemistry, Sep-12, Volume: 84	Zwitterionic pyrimidinium adducts as antioxidants with therapeutic potential as nitric oxide scavenger.
AID722249	Antioxidant activity assessed as DPPH radical scavenging activity in ethanol solution at 100 ug/mL	2013	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 23, Issue:3	Synthesis and antioxidant activity of thymol and carvacrol based Schiff bases.
AID1384553	Antioxidant activity assessed as DPPH radical scavenging activity incubated under dark condition for 30 mins	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Design and synthesis of novel pyrrolo[2,3-a]carbazoles: 7-Chloro-2-oxo-3a-(2'-oxo-2',3'-dihydro-1'H-indol-3'-yl)-2,3,3a,4,5,10-hexahydro-pyrrolo[3,2-a]carbazole-1-carbonitrile as an efficient anticancer agent.
AID567050	Antioxidant activity assessed as reduction of ABTS radical at 0.1 mM	2011	European journal of medicinal chemistry, Jan, Volume: 46, Issue:1	Design, synthesis and pharmacobiological evaluation of novel acrylic acid derivatives acting as lipoxygenase and cyclooxygenase-1 inhibitors with antioxidant and anti-inflammatory activities.
AID511051	Antioxidant activity assessed as nitric oxide scavenging activity at 100 uM after 120 min by Griess assay	2010	European journal of medicinal chemistry, Sep, Volume: 45, Issue:9	Synthesis and bioassay of aminosulfonyl-1,3,4-oxadiazoles and their interconversion to 1,3,4-thiadiazoles.
AID228869	Free radical scavenging assessed as 50% reduction in DPPH absorbance (516 nm)	2002	Journal of medicinal chemistry, Jan-17, Volume: 45, Issue:2	Synthesis and characterization of a series of novel monoacylated ascorbic acid derivatives, 6-O-acyl-2-O-alpha-D-glucopyranosyl-L-ascorbic acids, as skin antioxidants.
AID594792	Antioxidant activity assessed as xanthine-xanthine oxidase generated superoxide anion scavenging after 20 mins	2011	Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10	Synthesis of cinnamoyl ketoamides as hybrid structures of antioxidants and calpain inhibitors.
AID722251	Antioxidant activity assessed as DPPH radical scavenging activity in ethanol solution at 25 ug/mL	2013	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 23, Issue:3	Synthesis and antioxidant activity of thymol and carvacrol based Schiff bases.
AID1453459	Antioxidant activity of the compound in phosphate buffer at pH 6.6 assessed as potassium ferric cyanide ion reducing activity at 5 umol/ml after 20 mins by spectrophotometric method relative to control	2017	Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13	Synthesis of methanesulphonamido-benzimidazole derivatives as gastro-sparing antiinflammatory agents with antioxidant effect.
AID1530292	Antioxidant activity assessed as DPPH radical scavenging activity at 1 mM after 30 mins by spectrophotometric method relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Synthesis of cinnamic amide derivatives and their anti-melanogenic effect in α-MSH-stimulated B16F10 melanoma cells.
AID1555978	Antioxidant activity assessed as DPPH radical scavenging activity at 100 uM incubated for 2 hrs under dark condition relative to control	2019	European journal of medicinal chemistry, Sep-01, Volume: 177	Design, synthesis, and biological evaluation of rutacecarpine derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease.
AID1428670	Antiradical activity assessed as gallic acid equivalents of Foline-Ciocalteu reagent reducing capacity at 1 mM preincubated for 5 mins followed by Na2CO3 addition measured after 90 mins in presence of silybin	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Novel flavonolignan hybrid antioxidants: From enzymatic preparation to molecular rationalization.
AID701010	Antioxidant activity assessed as DPPH radical scavenging activity at 100 uM	2011	Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13	Discovery and biological evaluation of a novel class of dual microsomal prostaglandin E2 synthase-1/5-lipoxygenase inhibitors based on 2-[(4,6-diphenethoxypyrimidin-2-yl)thio]hexanoic acid.
AID1238055	Antioxidant activity assessed as nitric oxide radical scavenging activity at 500 uM incubated for 60 mins with light exposure at room temperature by Griess assay	2015	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16	Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives.
AID1193492	Thermodynamic equilibrium solubility, log S of the compound in water at RT after 4 hrs by 96 well plate method	2015	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7	Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery.
AID549274	Antioxidant activity in mouse BNL-CL2 cells assessed as inhibition of H2O2-induced ROS production at 20 ug/ml by DCFHDA assay	2010	Journal of natural products, Nov-29, Volume: 73, Issue:11	Inhibition of melanogenesis and oxidation by protocatechuic acid from Origanum vulgare (oregano).
AID594174	Antioxidant activity in rat erythrocytes assessed as inhibition of peroxyl radicals-induced hemolysis at 2 mM after 2 hrs	2011	European journal of medicinal chemistry, May, Volume: 46, Issue:5	Synthesis, antimicrobial, antioxidant, anti-hemolytic and cytotoxic evaluation of new imidazole-based heterocycles.
AID1366172	Antioxidant activity assessed as DPPH free radical scavenging activity at 25 ug/ml after 30 mins by spectrophotometric analysis	2017	Bioorganic & medicinal chemistry, 11-01, Volume: 25, Issue:21	Design and synthesis of benzimidazole-based Rho kinase inhibitors for the treatment of glaucoma.
AID1155644	Antioxidant activity assessed as 300 uM DPPH free radical scavenging activity under dark condition after 30 mins by microplate reader analysis	2014	Journal of natural products, Jun-27, Volume: 77, Issue:6	Lignans from the fruit of Schisandra glaucescens with antioxidant and neuroprotective properties.
AID468431	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins	2009	Journal of natural products, Oct, Volume: 72, Issue:10	Lipocarbazoles, secondary metabolites from Tsukamurella pseudospumae Acta 1857 with antioxidative activity.
AID1428680	Cytoprotective activity against tert-butyl hydroperoxide-induced decrease in cell viability in human HepG2 cells at 5 uM pretreated for 1 hr followed by co-treatment with tert-butyl hydroperoxide for 3 hrs in presence of silybin by MTT assay	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Novel flavonolignan hybrid antioxidants: From enzymatic preparation to molecular rationalization.
AID615460	Antioxidant activity in rat liver cells assessed as inhibition of Fe(2+)-asocrbate complex system-induced lipid peroxidation by TBARS assay	2011	European journal of medicinal chemistry, May, Volume: 46, Issue:5	Synthesis and bio-activity evaluation of tetraphenyl(phenylamino) methylene bisphosphonates as antioxidant agents and as potent inhibitors of osteoclasts in vitro.
AID294916	Antioxidant activity assessed as nitric oxide radical scavenging activity at 0.8 ug/ml after 150 mins	2007	European journal of medicinal chemistry, Aug, Volume: 42, Issue:8	Syntheses of new tetrasubstituted thiophenes as novel anti-inflammatory agents.
AID295620	ABTS radical scavenging activity at 200 ppm	2007	Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11	Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit.
AID762740	Antioxidant activity assessed as DPPH free radical scavenging activity at 50 ug/ml after 20 mins	2013	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 23, Issue:16	Novel pyrazoline amidoxime and their 1,2,4-oxadiazole analogues: synthesis and pharmacological screening.
AID764771	Antioxidant activity assessed as DPPH radical scavenging activity at 20 uM after 30 mins	2013	Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17	Design, synthesis and pharmacological evaluation of (E)-3,4-dihydroxy styryl sulfonamides derivatives as multifunctional neuroprotective agents against oxidative and inflammatory injury.
AID174639	Effect of AOS scavenger on arrhythmias induced by ischemia-reperfusion in anesthetized rat measured as ventricular tachycardia (VT), duration at 3 mg/kg	1988	Journal of medicinal chemistry, Apr, Volume: 31, Issue:4	Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID1071364	Antioxidant activity assessed as DPPH free radical scavenging activity at 50 uM after 30 mins by spectrophotometry	2014	European journal of medicinal chemistry, Feb-12, Volume: 73	Synthesis and antiproliferative activity of novel selenoester derivatives.
AID439062	Antioxidant activity in rat liver homogenate assessed as inhibition of iron-ascorbic acid mix-induced lipid peroxidation by TBARS assay	2009	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 19, Issue:21	Glucose-containing flavones--their synthesis and antioxidant and neuroprotective activities.
AID666942	Antioxidant activity assessed as authentic peroxynitrite radical scavenging activity after 5 mins by spectrophotometry	2012	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13	Evaluation of novel antioxidant triterpenoid saponins from the halophyte Salicornia herbacea.
AID1508038	Antioxidant activity in albino rat assessed as inhibition of catalase induced H2O2 production	2017	European journal of medicinal chemistry, Sep-29, Volume: 138	Azaphenothiazines - promising phenothiazine derivatives. An insight into nomenclature, synthesis, structure elucidation and biological properties.
AID762736	Antioxidant activity against ferric chloride-induced lipid peroxidation using egg lecithin at 10 ug/ml after 1 hr	2013	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 23, Issue:16	Novel pyrazoline amidoxime and their 1,2,4-oxadiazole analogues: synthesis and pharmacological screening.
AID1391584	Antioxidant activity assessed as hydroxyl radical scavenging activity at 2.5 mg/ml preincubated for 20 mins followed by salicylic acid addition measured after 60 mins by fenton reaction method relative to control	2018	Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9	Structural analysis and antioxidant activity of the glycoside from Imperial Chrysanthemum.
AID293286	Inhibition of AAPH-induced ram erythrocyte hemolysis at 1 g/L	2007	Bioorganic & medicinal chemistry, Feb-15, Volume: 15, Issue:4	Synthesis and antioxidant activity evaluation of new 7-aryl or 7-heteroarylamino-2,3-dimethylbenzo[b]thiophenes obtained by Buchwald-Hartwig C-N cross-coupling.
AID448093	Antimicrobial activity against Bacillus subtilis NCIM 2010 after 24 hrs by disk diffusion method	2009	European journal of medicinal chemistry, Nov, Volume: 44, Issue:11	Antioxidant and antibacterial studies of arylazopyrazoles and arylhydrazonopyrazolones containing coumarin moiety.
AID463979	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by spectrometric assay method	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis and antioxidant properties of enone core based dendrimers with carbazole as surface group.
AID1762407	Antioxidant activity assessed as trolox equivalent of ABTS radical cation scavenging activity incubated for 24 hrs by UV-Vis spectrophotometric analysis	2021	European journal of medicinal chemistry, Jun-05, Volume: 218	Novel potent bifunctional carboxylesterase inhibitors based on a polyfluoroalkyl-2-imino-1,3-dione scaffold.
AID1668232	Antioxidant activity assessed as nitric oxide radical scavenging activity	2020	Bioorganic & medicinal chemistry letters, 06-15, Volume: 30, Issue:12	Synthesis of novel of 2, 5-disubstituted 1, 3, 4- oxadiazole derivatives and their in vitro anti-inflammatory, anti-oxidant evaluation, and molecular docking study.
AID626497	Antioxidant activity assessed as ABTS radical scavenging activity after 3 mins by spectrophotometric analysis	2011	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 21, Issue:22	Synthesis and antioxidant activities of novel 4-Schiff base-7-benzyloxy-coumarin derivatives.
AID464442	Antioxidant activity assessed as reduction of F3+/ferricyanide complex after 20 mins by spectrophotometry	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis of new spiroindolinones incorporating a benzothiazole moiety as antioxidant agents.
AID496819	Antimicrobial activity against Plasmodium falciparum	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
AID1549506	Haemolytic activity in human erythrocytes assessed as induction of hemolysis at 5 mM after 30 mins relative to H202	2019	European journal of medicinal chemistry, May-01, Volume: 169	Anticancer activity, dual prooxidant/antioxidant effect and apoptosis induction profile of new bichalcophene-5-carboxamidines.
AID762735	Antioxidant activity against ferric chloride-induced lipid peroxidation using egg lecithin at 100 ug/ml after 1 hr	2013	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 23, Issue:16	Novel pyrazoline amidoxime and their 1,2,4-oxadiazole analogues: synthesis and pharmacological screening.
AID1362636	Antioxidant activity assessed as AAPH radical scavenging activity at 1 to 16 uM by ORAC assay
AID1762403	Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method	2021	European journal of medicinal chemistry, Jun-05, Volume: 218	Novel potent bifunctional carboxylesterase inhibitors based on a polyfluoroalkyl-2-imino-1,3-dione scaffold.
AID187612	Reducing activity determined by the use of stable radical alpha,alpha-di-phenyl-beta-picrylhydrazyl (DPPH)	1988	Journal of medicinal chemistry, Apr, Volume: 31, Issue:4	Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID1419294	Antioxidant activity assessed as ferric ion reducing activity at 20 to 320 umol after 20 mins by FRAP assay	2018	Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22	Synthesis and in vitro antitumor activity of novel alkenyl derivatives of pyridoxine, bioisosteric analogs of feruloyl methane.
AID1437487	Antioxidant activity assessed as ABTS radical scavenging activity	2017	Journal of natural products, 01-27, Volume: 80, Issue:1	Antioxidant Hydroanthraquinones from the Marine Algal-Derived Endophytic Fungus Talaromyces islandicus EN-501.
AID1651605	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins
AID1391579	Antioxidant activity assessed as ABTS radical scavenging activity at 2.5 mg/ml after 6 mins relative to control	2018	Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9	Structural analysis and antioxidant activity of the glycoside from Imperial Chrysanthemum.
AID1610483	Antioxidant activity assessed as decrease in ABTS radical cation scavenging activity every 1 min for 6 mins by UV-Vis spectrophotometric analysis	2019	Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23	Synthesis of 2-arylhydrazinylidene-3-oxo-4,4,4-trifluorobutanoic acids as new selective carboxylesterase inhibitors and radical scavengers.
AID1474166	Liver toxicity in human assessed as induction of drug-induced liver injury by measuring severity class index	2016	Drug discovery today, Apr, Volume: 21, Issue:4	DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
AID409958	Inhibition of bovine brain MAOA	2008	Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21	Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
AID1487486	Antioxidant activity assessed as DPPH free radical scavenging activity measured after 15 mins by spectrophotometric method	2017	Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16	Synthesis, antioxidant, antifungal, molecular docking and ADMET studies of some thiazolyl hydrazones.
AID437951	Antioxidant activity in Wistar rat brain assessed as lipid peroxidation	2010	European journal of medicinal chemistry, Jan, Volume: 45, Issue:1	Synthesis, spectral characterization and biological evaluation of phosphorylated derivatives of galanthamine.
AID1366177	Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins by spectrophotometric analysis	2017	Bioorganic & medicinal chemistry, 11-01, Volume: 25, Issue:21	Design and synthesis of benzimidazole-based Rho kinase inhibitors for the treatment of glaucoma.
AID1810881	Inhibition of human AChE using acetylthiocholine iodide as substrate incubated for 20 mins followed by substrate addition by Ellman's method
AID1267475	Antioxidant activity assessed as DPPH radical scavenging activity at 0.5 mM after 30 mins	2016	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1	Bioactive minor components of the total salvianolic acids injection prepared from Salvia miltiorrhiza Bge.
AID1875631	Immunomodulatory activity in IL-17A Katushka/IL-10eGFP/Foxp3RFP reporter mouse cell trace violet-labelled CD4+ T cell derived TGF-beta1/IL-6/IL-23-polarized Th17 cells assessed as increase in IL-10 positive cell population at 5 to 20 uM measured after 3 d	2022	Journal of natural products, 11-25, Volume: 85, Issue:11	Cellular Stress-Induced Metabolites in
AID1428676	Antioxidant activity against tert-butyl hydroperoxide-induced lipoperoxidation in rat liver microsomal membranes preincubated for 10 mins followed by tert-butyl hydroperoxide addition measured after 60 mins in presence of silybin by TBARS assay	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Novel flavonolignan hybrid antioxidants: From enzymatic preparation to molecular rationalization.
AID1172553	Antioxidant activity assessed as DPPH radical scavenging activity	2014	European journal of medicinal chemistry, Nov-24, Volume: 87	Synthetic derivatives of aromatic abietane diterpenoids and their biological activities.
AID1331318	Antioxidant activity assessed as inhibition of peroxyl radical-induced oxidation at 10 uM by ORAC assay	2017	Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2	Synthesis and application of β-carbolines as novel multi-functional anti-Alzheimer's disease agents.
AID502057	Antioxidant activity assessed as DPPH radical scavenging activity at 400 ug/ml	2010	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17	InCl3 mediated one-pot multicomponent synthesis, anti-microbial, antioxidant and anticancer evaluation of 3-pyranyl indole derivatives.
AID1202779	Antioxidant activity assessed as trolox equivalent of ABTS radical scavenging activity measured for 1 to 6 mins by lipophilic-TEAC fluorescence assay	2015	Journal of natural products, Feb-27, Volume: 78, Issue:2	Antioxidative compounds from Garcinia buchananii stem bark.
AID1331319	Antioxidant activity assessed as ABTS free radical scavenging activity at 10 uM	2017	Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2	Synthesis and application of β-carbolines as novel multi-functional anti-Alzheimer's disease agents.
AID1663838	Antioxidant activity assessed as ferric reducing ability	2020	Bioorganic & medicinal chemistry letters, 07-15, Volume: 30, Issue:14	Isolation and biological activity of agrostophillinol from kaffir lime (Citrus hystrix) leaves.
AID1347864	Inhibition of alpha-MSH-induced TRP-2 expression in human A375 cells at 25 uM after 24 hrs by Western blot method	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	Design, synthesis and evaluation of novel dihydrostilbene derivatives as potential anti-melanogenic skin-protecting agents.
AID1367017	Antioxidant activity assessed as DPPH radical scavenging activity by spectrophotometric method	2017	Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24	Exploration of multi-target potential of chromen-4-one based compounds in Alzheimer's disease: Design, synthesis and biological evaluations.
AID1125419	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by microplate reader analysis	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Two sarcoviolins with antioxidative and α-glucosidase inhibitory activity from the edible mushroom Sarcodon leucopus collected in Tibet.
AID453281	Antioxidant activity assessed as peroxyl radical scavenging activity by measuring oxygen radical absorbance capacity	2009	Bioorganic & medicinal chemistry, Oct-15, Volume: 17, Issue:20	Synthesis and antioxidant properties of new chromone derivatives.
AID377603	Antioxidant activity assessed as DPPH radical scavenging activity at 100 uM	2006	Journal of natural products, Jun, Volume: 69, Issue:6	C18 dibenzocyclooctadiene lignans from Kadsura philippinensis.
AID396449	Anti-aging activity in human dermal fibroblasts assessed as inhibition rate of MMP1 expression at 1 uM relative to control	2009	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2	Synthesis and in vitro biological activity of retinyl polyhydroxybenzoates, novel hybrid retinoid derivatives.
AID1487715	Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins	2017	Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16	Antileishmanial potential of fused 5-(pyrazin-2-yl)-4H-1,2,4-triazole-3-thiols: Synthesis, biological evaluations and computational studies.
AID652731	Antioxidant activity using ethanol as substrate assessed as hydroxy radical additive level at 1 mmol/L after gamma-irradiation	2012	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7	Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
AID1505136	Inhibition of mushroom tyrosinase using L-tyrosine as substrate pretreated for 5 mins followed by substrate addition measured over 30 mins by spectrophotometric method	2018	Journal of natural products, 01-26, Volume: 81, Issue:1	Isolation of Flavonoids and Flavonoid Glycosides from Myrsine africana and Their Inhibitory Activities against Mushroom Tyrosinase.
AID693506	Antioxidant activity assessed as inhibition of nitric oxide free radical production at 25 ug/mL after 150 mins by Griess method relative to control	2012	European journal of medicinal chemistry, Dec, Volume: 58	Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d]pyrimidine derivatives.
AID648402	Antioxidant activity of the compound assessed as DPPH radical scavenging activity at 400 ug/ml after 20 mins	2012	European journal of medicinal chemistry, May, Volume: 51	Facile synthesis, characterization and pharmacological activities of 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles and 5,6-dihydro-3,6-disubstituted-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles.
AID1153383	Antioxidant activity assessed as DPPH radical scavenging activity	2014	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 24, Issue:13	Conventional and microwave assisted synthesis of pyrazolone Mannich bases possessing anti-inflammatory, analgesic, ulcerogenic effect and antimicrobial properties.
AID1743178	Antioxidant activity assessed as AAPH scavenging activity by measuring residual fluorescence at 10 uM measured at 1 min interval for 30 mins by ORAC fluorescein assay relative to control	2020	European journal of medicinal chemistry, Dec-15, Volume: 208	Multiple biological active 4-aminopyrazoles containing trifluoromethyl and their 4-nitroso-precursors: Synthesis and evaluation.
AID722986	Inhibition of Wistar albino rat xanthine oxidase isolated from liver using xanthine as substrate incubated for 15 mins prior to substrate addition by spectrophotometric analysis	2013	Bioorganic & medicinal chemistry, Jan-01, Volume: 21, Issue:1	Trisubstituted thiophene analogues of 1-thiazolyl-2-pyrazoline, super oxidase inhibitors and free radical scavengers.
AID1360874	Antioxidant activity assessed as ferric ion reduction by measuring FeSO4 equivalents reducing Fe3+-TPTZ to Fe2+-TPTZ at 80 ug/ml after 25 mins by FRAP assay	2018	European journal of medicinal chemistry, Jul-15, Volume: 155	Synthesis and biological evaluation of new coumarins bearing 2,4-diaminothiazole-5-carbonyl moiety.
AID215973	Compound (0.5 mM) was tested for percent inactivation of mushroom tyrosinase after 130 min with addition of enzyme	2003	Bioorganic & medicinal chemistry letters, Jul-21, Volume: 13, Issue:14	Identification of oxidation product of arbutin in mushroom tyrosinase assay system.
AID652905	Antioxidant activity using deaerated 0.1 M alpha-glucosophosphate as substrate assessed as inorganic phosphate level at 1 mmol/L after gamma-irradiation (Rvb = 2.63 +/- 0.05 10'7 mol/J)	2012	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7	Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
AID683417	Antioxidant activity assessed as DPPH free radical scavenging activity incubated for 30 mins	2012	Bioorganic & medicinal chemistry, Jul-01, Volume: 20, Issue:13	Synthesis of novel Schiff base analogues of 4-amino-1,5-dimethyl-2-phenylpyrazol-3-one and their evaluation for antioxidant and anti-inflammatory activity.
AID1428666	Antioxidant activity against tert-butyl hydroperoxide-induced lipoperoxidation in rat liver microsomal membranes preincubated for 10 mins followed by tert-butyl hydroperoxide addition measured after 60 mins by TBARS assay	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Novel flavonolignan hybrid antioxidants: From enzymatic preparation to molecular rationalization.
AID1663501	Antioxidant activity assessed as DPPH radical scavenging activity	2020	Bioorganic & medicinal chemistry letters, 08-01, Volume: 30, Issue:15	3,4-Dihydroxyphenethyl nitrate with nitric oxide releasing, antioxidant, hypoglycemic and hypolipidemic effects.
AID1768733	Inhibition of electric eel AChE by Ellman's method	2021	Bioorganic & medicinal chemistry letters, 10-01, Volume: 49	Design, synthesis and biological evaluation of naringenin carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
AID688614	Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins by spectrophotometry	2011	Journal of natural products, Aug-26, Volume: 74, Issue:8	Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.
AID1194986	Antioxidant activity assessed as FRAP values at 100 ug/ml incubated at 37 degC for 5 mins by FeSO4.7H2O calibration curve based method	2015	Bioorganic & medicinal chemistry letters, , Volume: 25, Issue:10	Cytotoxic and antioxidant constituents from the leaves of Psidium guajava.
AID1360876	Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins under dark condition by spectrophotometric method	2018	European journal of medicinal chemistry, Jul-15, Volume: 155	Synthesis and biological evaluation of new coumarins bearing 2,4-diaminothiazole-5-carbonyl moiety.
AID762897	Total antioxidant capacity of the compound at 25 uM relative to control	2013	Journal of natural products, Aug-23, Volume: 76, Issue:8	Phaeolschidins A-E, five hispidin derivatives with antioxidant activity from the fruiting body of Phaeolus schweinitzii collected in the Tibetan Plateau.
AID1178157	Antioxidant activity of the compound assessed as reduction in absorbance of DPPH after 60 mins incubation at 300 uM by DPPH radical scavenging /microplate assay	2014	Bioorganic & medicinal chemistry, May-01, Volume: 22, Issue:9	Synthesis, antioxidant and photoprotection activities of hybrid derivatives useful to prevent skin cancer.
AID604088	Antioxidant activity assessed as DPPH radical scavenging activity	2011	Bioorganic & medicinal chemistry, Jun-15, Volume: 19, Issue:12	Significant enhancement in radical-scavenging activity of curcuminoids conferred by acetoxy substituent at the central methylene carbon.
AID396447	Toxicity against human dermal fibroblasts assessed as cell viability at 200 uM relative to control	2009	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2	Synthesis and in vitro biological activity of retinyl polyhydroxybenzoates, novel hybrid retinoid derivatives.
AID496820	Antimicrobial activity against Trypanosoma brucei	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
AID1313281	Antioxidant activity assessed as DPPH radical scavenging activity at 60 ug/ml after 20 mins by spectrophotometry relative to control	2016	Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15	Synthesis of lignan conjugates via cyclopropanation: Antimicrobial and antioxidant studies.
AID1730961	Antioxidant activity assessed as nitric oxide radical scavenging activity at 25 ug/ml (Rvb = 25.8 to 41.6 %)	2021	Bioorganic & medicinal chemistry letters, 03-15, Volume: 36	Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme.
AID496831	Antimicrobial activity against Cryptosporidium parvum	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
AID1248048	Antioxidant activity assessed as inhibition of AAPH-induced lipid peroxidation at 200 ug/ml after 3 hrs by TBA-MDA test	2015	Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19	Synthesis, electronic properties, antioxidant and antibacterial activity of some new benzimidazoles.
AID1877876	Antioxidant activity assessed as hydrogen peroxide scavenging activity
AID390103	Antioxidant activity assessed as DPPH radical scavenging activity by Brand-Williams method	2008	Journal of natural products, Dec, Volume: 71, Issue:12	S-alkenyl cysteine sulfoxide and its antioxidant properties from Allium cepa var. tropeana (red onion) seeds.
AID1463492	Neuroprotective activity against glutamate-induced neuronal cell death in mouse HT22 cells at 25 uM after 24 hrs by LDH-release assay relative to control	2017	Bioorganic & medicinal chemistry letters, 09-15, Volume: 27, Issue:18	Synthesis of 3-[4-(dimethylamino)phenyl]alkyl-2-oxindole derivatives and their effects on neuronal cell death.
AID1238916	Antioxidant activity assessed as inhibition of DPPH radical generation at 100 ug/ml after 30 mins relative to control	2015	Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17	Synthesis, kinetic mechanism and docking studies of vanillin derivatives as inhibitors of mushroom tyrosinase.
AID1428665	Antioxidant activity assessed as trolox equivalent of ABTS radical scavenging activity at 100 uM measured at >= 5 mins	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Novel flavonolignan hybrid antioxidants: From enzymatic preparation to molecular rationalization.
AID693502	Antioxidant activity assessed as inhibition of DPPH free radical production at 50 ug/mL after 30 mins by spectrophotometric analysis relative to control	2012	European journal of medicinal chemistry, Dec, Volume: 58	Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d]pyrimidine derivatives.
AID536046	Antioxidant activity against ABTS radical assessed as Trolox equivalent	2010	Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22	Synthesis and antioxidant properties of pulvinic acids analogues.
AID666940	Antioxidant activity assessed as DPPH radical scavenging activity a 50 ug/ml after 30 mins by spectrophotometry	2012	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13	Evaluation of novel antioxidant triterpenoid saponins from the halophyte Salicornia herbacea.
AID1366173	Antioxidant activity assessed as DPPH free radical scavenging activity at 50 ug/ml after 30 mins by spectrophotometric analysis	2017	Bioorganic & medicinal chemistry, 11-01, Volume: 25, Issue:21	Design and synthesis of benzimidazole-based Rho kinase inhibitors for the treatment of glaucoma.
AID396456	Antioxidant activity assessed as free radical scavenging activity at 5 uM	2009	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2	Synthesis and in vitro biological activity of retinyl polyhydroxybenzoates, novel hybrid retinoid derivatives.
AID427661	Antioxidant activity assessed as inhibition of FeCl2-induced lipid peroxidation by thiocyanate method	2009	Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13	Potential antioxidants and tyrosinase inhibitors from synthetic polyphenolic deoxybenzoins.
AID1595269	Acute toxicity in Swiss albino mouse assessed as reduction in mortality of animal at 200 to 800 mg/kg ip observed for 8 days	2019	European journal of medicinal chemistry, Jun-01, Volume: 171	Insights into the chemistry and therapeutic potential of furanones: A versatile pharmacophore.
AID1882443	Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins
AID1193495	Thermodynamic equilibrium solubility, log S of the compound in simulated intestinal fluid at pH 6.8 at RT after 4 hrs by 96 well plate method	2015	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7	Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery.
AID619973	Antioxidant activity assessed as DPPH free radical scavenging activity at 75 ug/ml after 30 mins by spectrophotometric analysis relative to control	2011	European journal of medicinal chemistry, Oct, Volume: 46, Issue:10	Synthesis and antioxidant activity of oxazolyl/thiazolylsulfonylmethyl pyrazoles and isoxazoles.
AID1238015	Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins	2015	Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15	Synthesis, molecular docking and biological evaluation of 3-arylfuran-2(5H)-ones as anti-gastric ulcer agent.
AID478244	Antioxidant activity in Wistar albino rat assessed as inhibition of superoxide dismutase activity	2010	European journal of medicinal chemistry, May, Volume: 45, Issue:5	Synthesis, spectral characterization and bioassay of 3,3'-(1,4-phenylene)-bis[2-alkoxycarbonyl-alkyl)-2-thio-benzoxa-phosphinines].
AID1368750	Inhibition of NOX4 in human ARPE19 cells assessed as protection against 4-HNE-induced cell death by measuring cell viability recovery at 10 uM incubated for 24 hrs by MTT assay	2018	Bioorganic & medicinal chemistry letters, 01-15, Volume: 28, Issue:2	Protective effects of 6-ureido/thioureido-2,4,5-trimethylpyridin-3-ols against 4-hydroxynonenal-induced cell death in adult retinal pigment epithelial-19 cells.
AID614061	Inhibition of bovine testes hyaluronidase at 130 uM after 30 mins at pH 5 by turbidimetric analysis	2011	European journal of medicinal chemistry, Sep, Volume: 46, Issue:9	Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase.
AID405698	Antioxidant activity against 2,2'-azobis (2-amidinopropane) dihydrochloride-induced fluorescence decay at 1.5 uM assessed as trolox equivalents by ORAC-fluorescence assay	2008	Journal of natural products, Jun, Volume: 71, Issue:6	Antioxidant 2-phenylbenzofurans and a coumestan from Lespedeza virgata.
AID549260	Antioxidant activity assessed as DPPH radical scavenging activity at 1 ug/ml after 30 mins	2010	Journal of natural products, Nov-29, Volume: 73, Issue:11	Inhibition of melanogenesis and oxidation by protocatechuic acid from Origanum vulgare (oregano).
AID1474167	Liver toxicity in human assessed as induction of drug-induced liver injury by measuring verified drug-induced liver injury concern status	2016	Drug discovery today, Apr, Volume: 21, Issue:4	DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
AID614060	Inhibition of bovine testes hyaluronidase at 3800 uM after 30 mins at pH 5 by turbidimetric analysis	2011	European journal of medicinal chemistry, Sep, Volume: 46, Issue:9	Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase.
AID292587	DPPH radical scavenging activity at 6.25 uM	2007	Journal of natural products, Jul, Volume: 70, Issue:7	Kadsuphilols A-H, oxygenated lignans from Kadsura philippinensis.
AID1405931	Antioxidant activity assessed as ferric ion reducing activity after 20 mins in presence of potassium ferricyanide by FRAP assay relative to control	2018	European journal of medicinal chemistry, Aug-05, Volume: 156	Current progress on antioxidants incorporating the pyrazole core.
AID385146	Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins	2008	Journal of natural products, Apr, Volume: 71, Issue:4	Citrinin dimers from the halotolerant fungus Penicillium citrinum B-57.
AID1651260	Inhibition of equine serum BChE using butyrylthiocholine as substrate by Ellman's method	2020	Bioorganic & medicinal chemistry letters, 02-15, Volume: 30, Issue:4	Design, synthesis and anti-Alzheimer's disease activity study of xanthone derivatives based on multi-target strategy.
AID1058428	Antioxidant activity assessed as hydrogen peroxide radical scavenging activity	2013	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24	The ameliorating effects of 2,3-dihydroxy-4-methoxyacetophenone on scopolamine-induced memory impairment in mice and its neuroprotective activity.
AID401338	Antioxidant activity assessed by singlet oxygen scavenging assay	1996	Journal of natural products, Feb, Volume: 59, Issue:2	Natural polyphenols (vegetable tannins) as drugs: possible modes of action.
AID1778222	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins under dark condition by DPPH assay relative to control	2021	European journal of medicinal chemistry, Aug-05, Volume: 220	Beyond direct Nrf2 activation; reinvestigating 1,2,4-oxadiazole scaffold as a master key unlocking the antioxidant cellular machinery for cancer therapy.
AID292583	DPPH radical scavenging activity at 100 uM	2007	Journal of natural products, Jul, Volume: 70, Issue:7	Kadsuphilols A-H, oxygenated lignans from Kadsura philippinensis.
AID657488	Inhibition of desert banana tyrosinase using p-cresol as substrate	2012	Bioorganic & medicinal chemistry, May-01, Volume: 20, Issue:9	New saccharin derivatives as tyrosinase inhibitors.
AID1549505	Haemolytic activity in human erythrocytes assessed as induction of hemolysis at 10 mM after 30 mins relative to H202	2019	European journal of medicinal chemistry, May-01, Volume: 169	Anticancer activity, dual prooxidant/antioxidant effect and apoptosis induction profile of new bichalcophene-5-carboxamidines.
AID1391583	Antioxidant activity assessed as inhibition of superoxide radical generation up to 0.6 mg/ml after 4 mins by pyrogallol autoxidation method relative to control	2018	Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9	Structural analysis and antioxidant activity of the glycoside from Imperial Chrysanthemum.
AID1610136	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Dec-15, Volume: 184	Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives.
AID323194	Protection against photoirradiation-induced lipid peroxidation damage in rat liver mitochondria at 10 mM	2008	Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6	Inhibitory property of the Piper betel phenolics against photosensitization-induced biological damages.
AID1255364	Antioxidant activity assessed as DPPH radical scavenging activity measured as discoloration incubated for 30 mins in dark relative to control	2015	European journal of medicinal chemistry, Oct-20, Volume: 103	Correlation of antioxidant activities with theoretical studies for new hydrazone compounds bearing a 3,4,5-trimethoxy benzyl moiety.
AID378650	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by spectrophotometer	2000	Journal of natural products, Dec, Volume: 63, Issue:12	A cyclohexanonyl bromophenol from the red alga Symphyocladia latiuscula.
AID1413964	Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins
AID1272819	Antioxidant activity of the compound assessed as DPPH radical scavenging after 30 mins by spectrophotometric analysis	2016	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3	Antileishmanial activity of novel indolyl-coumarin hybrids: Design, synthesis, biological evaluation, molecular docking study and in silico ADME prediction.
AID1635490	Neuroprotective activity against H2O2-induced oxidative damage in human SH-SY5Y cells assessed as increase in cell viability at 10 uM incubated for 2 hrs followed by H2O2 challenge measured after 24 hrs by MTT assay	2016	Journal of medicinal chemistry, 06-23, Volume: 59, Issue:12	Benzylpiperidine-Linked Diarylthiazoles as Potential Anti-Alzheimer's Agents: Synthesis and Biological Evaluation.
AID762333	Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins by spectrophotometry	2013	European journal of medicinal chemistry, Aug, Volume: 66	Microwave-assisted synthesis of some new pyrazolopyridines and their antioxidant, antitumor and antimicrobial activities.
AID1405932	Antioxidant activity assessed as nitric oxide radical scavenging activity at 100 mM after 150 mins in presence of sodium nitroprusside relative to control	2018	European journal of medicinal chemistry, Aug-05, Volume: 156	Current progress on antioxidants incorporating the pyrazole core.
AID1234556	Antioxidant activity assessed as DPPH radical scavenging activity after 30 min	2015	Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15	Synthesis of (2-amino)ethyl derivatives of quercetin 3-O-methyl ether and their antioxidant and neuroprotective effects.
AID1234557	Antioxidant activity assessed as superoxide anion radical scavenging activity after 20 mins by xanthine/xanthine oxidase method	2015	Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15	Synthesis of (2-amino)ethyl derivatives of quercetin 3-O-methyl ether and their antioxidant and neuroprotective effects.
AID1347579	Upregulation of COL1A1 mRNA expression in HDF at 100 uM after 48 hrs by RT-PCR analysis	2017	Journal of natural products, 11-22, Volume: 80, Issue:11	neo-Clerodane Diterpenoids from Salvia polystachya Stimulate the Expression of Extracellular Matrix Components in Human Dermal Fibroblasts.
AID666943	Antioxidant activity assessed as morpholinosydnonimine-derived peroxynitrite free radical scavenging activity after 5 mins by spectrophotometry	2012	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13	Evaluation of novel antioxidant triterpenoid saponins from the halophyte Salicornia herbacea.
AID1549511	Antioxidant activity assessed as DPPH radical scavenging activity incubated in dark for 30 mins by spectrophotometric method relative to ascorbic acid	2019	European journal of medicinal chemistry, May-01, Volume: 169	Anticancer activity, dual prooxidant/antioxidant effect and apoptosis induction profile of new bichalcophene-5-carboxamidines.
AID1347859	Growth inhibition of human A375 cells at 25 uM after 48 hrs by SRB assay relative to control	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	Design, synthesis and evaluation of novel dihydrostilbene derivatives as potential anti-melanogenic skin-protecting agents.
AID478241	Antioxidant activity in Wistar albino rat assessed as inhibition of catalase activity	2010	European journal of medicinal chemistry, May, Volume: 45, Issue:5	Synthesis, spectral characterization and bioassay of 3,3'-(1,4-phenylene)-bis[2-alkoxycarbonyl-alkyl)-2-thio-benzoxa-phosphinines].
AID1193496	Thermodynamic equilibrium solubility, log S of the compound in water at RT after 24 hrs by shake-flask method	2015	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7	Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery.
AID614064	Inhibition of bovine testes hyaluronidase at 2000 uM after 30 mins at pH 5 by turbidimetric analysis	2011	European journal of medicinal chemistry, Sep, Volume: 46, Issue:9	Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase.
AID1762290	Antioxidant activity assessed as DPPH radical scavenging activity	2021	Bioorganic & medicinal chemistry letters, 06-15, Volume: 42	Novel iodinated quinazolinones bearing sulfonamide as new scaffold targeting radiation induced oxidative stress.
AID377909	Antioxidant activity assessed as DPPH free radical scavenging activity	2000	Journal of natural products, Oct, Volume: 63, Issue:10	Urinary metabolites of gallic acid in rats and their radical-scavenging effects on 1,1-diphenyl-2-picrylhydrazyl radical.
AID720997	Antioxidant activity assessed as ABTS radical scavenging activity after 3 mins by spectrophotometry	2013	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1	Synthesis and antioxidant activities of 2-oxo-quinoline-3-carbaldehyde Schiff-base derivatives.
AID764457	Antioxidant activity assessed as DPPH free radical scavenging activity under dark condition after 30 mins	2013	European journal of medicinal chemistry, Aug, Volume: 66	Design, synthesis and evaluation of dialkyl 4-(benzo[d][1,3]dioxol-6-yl)-1,4-dihydro-2,6-dimethyl-1-substituted pyridine-3,5-dicarboxylates as potential anticonvulsants and their molecular properties prediction.
AID470659	Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins	2009	Journal of natural products, Sep, Volume: 72, Issue:9	Cerebrosides of the halotolerant fungus Alternaria raphani isolated from a sea salt field.
AID594791	Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins	2011	Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10	Synthesis of cinnamoyl ketoamides as hybrid structures of antioxidants and calpain inhibitors.
AID640884	Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins by microplate reader assay	2012	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 22, Issue:2	Antioxidative oligostilbenes from Caragana sinica.
AID1269943	Antioxidant activity assessed as DPPH radical scavenging activity	2016	Bioorganic & medicinal chemistry, Feb-15, Volume: 24, Issue:4	An appraisal on recent medicinal perspective of curcumin degradant: Dehydrozingerone (DZG).
AID603957	Octanol-water partition coefficient, log P of the compound	2008	European journal of medicinal chemistry, Apr, Volume: 43, Issue:4	QSPR modeling of octanol/water partition coefficient for vitamins by optimal descriptors calculated with SMILES.
AID614065	Inhibition of bovine testes hyaluronidase at 150 uM after 30 mins at pH 5 by turbidimetric analysis	2011	European journal of medicinal chemistry, Sep, Volume: 46, Issue:9	Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase.
AID666941	Antioxidant activity assessed as DPPH radical scavenging activity at 100 ug/ml after 30 mins by spectrophotometry	2012	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13	Evaluation of novel antioxidant triterpenoid saponins from the halophyte Salicornia herbacea.
AID1657449	Antioxidant activity assessed as DPPH radical scavenging activity measured for 5 mins by UV absorbance analysis	2020	Bioorganic & medicinal chemistry, 04-15, Volume: 28, Issue:8	Investigations of antiproliferative and antioxidant activity of β-lactam morpholino-1,3,5-triazine hybrids.
AID614055	Inhibition of bovine testes hyaluronidase at 180 uM after 30 mins at pH 5 by turbidimetric analysis	2011	European journal of medicinal chemistry, Sep, Volume: 46, Issue:9	Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase.
AID378648	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins	2000	Journal of natural products, Dec, Volume: 63, Issue:12	Activity-guided isolation of antioxidative constituents of Cotinus coggygria.
AID333821	Antioxidant activity against LDL-susceptible to oxidation in New Zealand White rabbit plasma assessed as increase in conjugated diene formation at 12.5 ug/mL after 30 mins	2004	Journal of natural products, Dec, Volume: 67, Issue:12	Bioactive compounds from the seeds of Punica granatum (pomegranate).
AID1610480	Inhibition of porcine liver carboxylesterase at 20 uM using 4-NPA as substrate preincubated for 10 mins followed by substrate addition by spectrophotometric analysis relative to control	2019	Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23	Synthesis of 2-arylhydrazinylidene-3-oxo-4,4,4-trifluorobutanoic acids as new selective carboxylesterase inhibitors and radical scavengers.
AID615465	Antioxidant activity assessed as hydrogen peroxide scavenging activity after 10 mins	2011	European journal of medicinal chemistry, May, Volume: 46, Issue:5	Novel dihydropyrimidines and its pyrazole derivatives: synthesis and pharmacological screening.
AID1486133	Antioxidant activity assessed as ABTS radical cation scavenging activity by measuring trolox equivalent antioxidant capacity at 20 uM after 1 hr by UV/Vis spectrophotometric analysis	2017	Bioorganic & medicinal chemistry, 08-01, Volume: 25, Issue:15	Synthesis, molecular docking, and biological activity of polyfluoroalkyl dihydroazolo[5,1-c][1,2,4]triazines as selective carboxylesterase inhibitors.
AID403395	Antioxidant activity in New Zealand White rabbit plasma assessed as increase in conjugated diene formation at 568 uM by thiobarbituric acid method	2005	Journal of natural products, Aug, Volume: 68, Issue:8	Neuroprotective and antioxidant activity of compounds from the aerial parts of Dioscorea opposita.
AID1453056	Antioxidant activity assessed as inhibition of DPPH radical generation at 0.05 mg/ml after 20 mins under dark condition by UV-Visible spectrophotometric analysis relative to control	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Synthesis, characterization, molecular docking and in vitro antimalarial properties of new carboxamides bearing sulphonamide.
AID620058	Antioxidant activity assessed as hydrogen peroxide scavenging activity at 50 ug/ml relative to control	2011	European journal of medicinal chemistry, Oct, Volume: 46, Issue:10	Synthesis and antioxidant activity of oxazolyl/thiazolylsulfonylmethyl pyrazoles and isoxazoles.
AID591507	Antihyperalgesic activity in rat assessed as reversal of oxaliplatin-induced mechanical hyperalgesia at 50 to 100 mg.kg, iv by paw pressure test	2011	Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7	Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs.
AID445598	Antioxidant activity assessed as DPPH radical scavenging activity	2010	European journal of medicinal chemistry, Jan, Volume: 45, Issue:1	Synthesis and antioxidant properties of some novel 5H-dibenz[b,f]azepine derivatives in different in vitro model systems.
AID1462748	Antioxidant activity assessed as DPPH free radical scavenging activity by measuring radical-scavenging activity factor (moles of radicals scavenged by each mol of antioxidant) at 20 uM measured at 120 mins by HPLC	2017	Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20	Structural evidence for the DPPH radical-scavenging mechanism of 2-O-α-d-glucopyranosyl-l-ascorbic acid.
AID390102	Antioxidant activity by ferric reducing antioxidant power assay	2008	Journal of natural products, Dec, Volume: 71, Issue:12	S-alkenyl cysteine sulfoxide and its antioxidant properties from Allium cepa var. tropeana (red onion) seeds.
AID652732	Antioxidant activity using 1M ethanol as substrate assessed as acetaldehyde level at 1 mmol/L after gamma-irradiation by gas chromatography (Rvb = 4.31 +/- 0.23 10'7 mol/J)	2012	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7	Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
AID1066679	Antioxidant activity assessed as DPPH radical scavenging activity	2014	Journal of natural products, Feb-28, Volume: 77, Issue:2	Dermacozines H-J isolated from a deep-sea strain of Dermacoccus abyssi from Mariana Trench sediments.
AID1533606	Inhibition of human serum BChE using butyrylthiocholine iodide as substrate after 10 mins measured for every mins by Ellman's method	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Design and development of some phenyl benzoxazole derivatives as a potent acetylcholinesterase inhibitor with antioxidant property to enhance learning and memory.
AID1428672	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins in presence of silybin by spectrophotometric method	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Novel flavonolignan hybrid antioxidants: From enzymatic preparation to molecular rationalization.
AID590510	Antioxidant activity assessed as DPPH free radical scavenging activity after 20 mins by spectrophotometric analysis	2011	European journal of medicinal chemistry, Apr, Volume: 46, Issue:4	Synthesis, biopharmaceutical characterization, antimicrobial and antioxidant activities of 1-(4'-O-β-D-glucopyranosyloxy-2'-hydroxyphenyl)-3-aryl-propane-1,3-diones.
AID1360870	Antioxidant activity assessed as ferric ion reduction by measuring FeSO4 equivalents reducing Fe3+-TPTZ to Fe2+-TPTZ at 5 ug/ml after 25 mins by FRAP assay	2018	European journal of medicinal chemistry, Jul-15, Volume: 155	Synthesis and biological evaluation of new coumarins bearing 2,4-diaminothiazole-5-carbonyl moiety.
AID183772	Effect of AOS scavenger on ventricular fibrillation (VF), arrhythmias induced by ischemia-reperfusion in anesthetized rat, incidence at 3 mg/kg; 6/6	1988	Journal of medicinal chemistry, Apr, Volume: 31, Issue:4	Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID355800	Antioxidant activity assessed as DPPH free radical scavenging activity by TLC autoradiographic assay	2003	Journal of natural products, May, Volume: 66, Issue:5	Marine natural products as novel antioxidant prototypes.
AID619977	Antioxidant activity assessed as nitric oxide scavenging activity at 75 ug/ml after 150 mins by Griess method relative to control	2011	European journal of medicinal chemistry, Oct, Volume: 46, Issue:10	Synthesis and antioxidant activity of oxazolyl/thiazolylsulfonylmethyl pyrazoles and isoxazoles.
AID1487485	Antioxidant activity assessed as DPPH free radical scavenging activity at 100 ug/ml after 15 mins by spectrophotometric method	2017	Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16	Synthesis, antioxidant, antifungal, molecular docking and ADMET studies of some thiazolyl hydrazones.
AID1428682	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability up to 10 uM after 4 hrs by MTT assay	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Novel flavonolignan hybrid antioxidants: From enzymatic preparation to molecular rationalization.
AID592726	Antioxidant activity assessed as DPPH radical scavenging activity at 64 uM after 10 mins	2011	Bioorganic & medicinal chemistry, Apr-15, Volume: 19, Issue:8	In vitro and QSAR studies of cucurbitacins on HepG2 and HSC-T6 liver cell lines.
AID1610479	Inhibition of porcine liver carboxylesterase using 4-NPA as substrate preincubated for 10 mins followed by substrate addition by spectrophotometric analysis	2019	Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23	Synthesis of 2-arylhydrazinylidene-3-oxo-4,4,4-trifluorobutanoic acids as new selective carboxylesterase inhibitors and radical scavengers.
AID25509	Partition ratio obtained from HPLC analysis.	1991	Journal of medicinal chemistry, Jul, Volume: 34, Issue:7	3-O-alkylascorbic acids as free-radical quenchers: synthesis and inhibitory effect on lipid peroxidation.
AID292584	DPPH radical scavenging activity at 50 uM	2007	Journal of natural products, Jul, Volume: 70, Issue:7	Kadsuphilols A-H, oxygenated lignans from Kadsura philippinensis.
AID722248	Antioxidant activity assessed as DPPH radical scavenging activity in ethanol solution at 50 ug/mL	2013	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 23, Issue:3	Synthesis and antioxidant activity of thymol and carvacrol based Schiff bases.
AID502056	Antioxidant activity assessed as DPPH radical scavenging activity at 200 ug/ml	2010	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17	InCl3 mediated one-pot multicomponent synthesis, anti-microbial, antioxidant and anticancer evaluation of 3-pyranyl indole derivatives.
AID744464	Antioxidant activity of the compound assessed as DPPH free radical scavenging activity at 62.5 uM after 60 mins by spectrophotometric analysis relative to control	2013	European journal of medicinal chemistry, May, Volume: 63	Synthesis and biological activities of some novel aminomethyl derivatives of 4-substituted-5-(2-thienyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones.
AID170003	Effect of AOS scavenger on premeture ventricular complexes PVCs, arrhythmias induced by ischemia-reperfusion in anesthetized rat, duration at 3 mg/kg	1988	Journal of medicinal chemistry, Apr, Volume: 31, Issue:4	Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID1768736	Antioxidant activity assessed as hydroxyl radical scavenging activity	2021	Bioorganic & medicinal chemistry letters, 10-01, Volume: 49	Design, synthesis and biological evaluation of naringenin carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
AID744463	Antioxidant activity of the compound assessed as DPPH free radical scavenging activity at 187.5 uM after 60 mins by spectrophotometric analysis relative to control	2013	European journal of medicinal chemistry, May, Volume: 63	Synthesis and biological activities of some novel aminomethyl derivatives of 4-substituted-5-(2-thienyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones.
AID179359	Effect of AOS scavenger on ventricular fibrillation (VF), arrhythmias induced by ischemia-reperfusion in anesthetized rat, incidence at 3 mg/kg	1988	Journal of medicinal chemistry, Apr, Volume: 31, Issue:4	Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID416578	Stimulation of collagen biosynthesis in primary cultured neonatal HDF at 1 to 1000 uM after 72 hrs by ELISA in presence of fetal bovine serum	2009	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 19, Issue:7	Design and efficient synthesis of novel ascorbyl conjugated peptide with high collagen biosynthesis stimulating effects.
AID1383666	Antioxidant activity assessed as DPPH radical scavenging activity at 10 uM after 25 mins	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Development of Piperazinediones as dual inhibitor for treatment of Alzheimer's disease.
AID642765	Antioxidant activity assessed as DPPH free radical scavenging activity at 50 ug by spectrophotometer	2012	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 22, Issue:3	An efficient synthesis of highly functionalized novel chromeno[4,3-b]pyrroles and indolizino[6,7-b]indoles as potent antimicrobial and antioxidant agents.
AID1428681	Cytoprotective activity against tert-butyl hydroperoxide-induced toxicity in human HepG2 cells assessed as cell viability at 5 uM pretreated for 1 hr followed by tert-butyl hydroperoxide addition for 3 hrs by MTT assay (Rvb = 16%)	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Novel flavonolignan hybrid antioxidants: From enzymatic preparation to molecular rationalization.
AID1193497	Thermodynamic equilibrium solubility, log S of the compound PBS at pH 7.4 at RT after 24 hrs by shake-flask method	2015	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7	Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery.
AID1139639	Antioxidant activity assessed as DPPH free radical scavenging effect after 30 mins by spectrophotometric analysis	2014	Journal of medicinal chemistry, May-22, Volume: 57, Issue:10	Design, synthesis, and biological evaluation of (e)-3,4-dihydroxystyryl aralkyl sulfones and sulfoxides as novel multifunctional neuroprotective agents.
AID1347858	Inhibition of tyrosinase in mouse B16 cells assessed as effect on alpha-MSH-induced melanin formation at 25 uM after 24 hrs relative to control	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	Design, synthesis and evaluation of novel dihydrostilbene derivatives as potential anti-melanogenic skin-protecting agents.
AID437944	Inhibition of catalase in Wistar rat brain	2010	European journal of medicinal chemistry, Jan, Volume: 45, Issue:1	Synthesis, spectral characterization and biological evaluation of phosphorylated derivatives of galanthamine.
AID1058429	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins	2013	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24	The ameliorating effects of 2,3-dihydroxy-4-methoxyacetophenone on scopolamine-induced memory impairment in mice and its neuroprotective activity.
AID502063	Antioxidant activity assessed as ABTS radical scavenging activity	2010	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17	InCl3 mediated one-pot multicomponent synthesis, anti-microbial, antioxidant and anticancer evaluation of 3-pyranyl indole derivatives.
AID652725	Cytotoxicity against human RD cells assessed maximun non-toxic concentration	2012	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7	Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
AID1076257	Antioxidant activity assessed as NO radical scavenging activity after 150 mins by griess reagent method	2014	European journal of medicinal chemistry, Mar-21, Volume: 75	Synthesis, docking and evaluation of antioxidant and antimicrobial activities of novel 1,2,4-triazolo[3,4-b][1,3,4]thiadiazol-6-yl)selenopheno[2,3-d]pyrimidines.
AID478245	Antioxidant activity in Wistar albino rat assessed as lipid peroxidation level	2010	European journal of medicinal chemistry, May, Volume: 45, Issue:5	Synthesis, spectral characterization and bioassay of 3,3'-(1,4-phenylene)-bis[2-alkoxycarbonyl-alkyl)-2-thio-benzoxa-phosphinines].
AID1549509	Haemolytic activity in human erythrocytes assessed as induction of hemolysis at 0.625 mM after 30 mins relative to H202	2019	European journal of medicinal chemistry, May-01, Volume: 169	Anticancer activity, dual prooxidant/antioxidant effect and apoptosis induction profile of new bichalcophene-5-carboxamidines.
AID1194981	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by microplate reader based assay	2015	Bioorganic & medicinal chemistry letters, , Volume: 25, Issue:10	Cytotoxic and antioxidant constituents from the leaves of Psidium guajava.
AID1608424	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins under dark condition	2019	European journal of medicinal chemistry, Oct-15, Volume: 180	Role of sulphur-heterocycles in medicinal chemistry: An update.
AID1234180	Antioxidative activity assessed as ABTS cation radical scavenging activity	2015	Journal of natural products, Jul-24, Volume: 78, Issue:7	Indole Alkaloids from Chaetomium globosum.
AID761967	Antioxidant activity assessed as DPPH scavenging activity after 30 mins by UV-visible spectrophotometry	2013	European journal of medicinal chemistry, Aug, Volume: 66	Novel 2-(2,4-dioxo-1,3-thiazolidin-5-yl)acetamides as antioxidant and/or anti-inflammatory compounds.
AID615467	Antioxidant activity assessed as potassium ferricyanide ion reducing power after 20 mins	2011	European journal of medicinal chemistry, May, Volume: 46, Issue:5	Novel dihydropyrimidines and its pyrazole derivatives: synthesis and pharmacological screening.
AID1487137	Antioxidant activity assessed as inhibition of ferrous sulfate-induced lipid peroxidation after 30 mins	2017	Bioorganic & medicinal chemistry, 08-15, Volume: 25, Issue:16	Phenylsulfonylfuroxan NO-donor phenols: Synthesis and multifunctional activities evaluation.
AID478243	Antioxidant activity in Wistar albino rat assessed as reduced glutathione activity	2010	European journal of medicinal chemistry, May, Volume: 45, Issue:5	Synthesis, spectral characterization and bioassay of 3,3'-(1,4-phenylene)-bis[2-alkoxycarbonyl-alkyl)-2-thio-benzoxa-phosphinines].
AID1389182	Antioxidant activity in brain homogenate (unknown origin) assessed as decrease in TBARS formation by UV-visible spectrophotometric method	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	In silico studies, synthesis and pharmacological evaluation to explore multi-targeted approach for imidazole analogues as potential cholinesterase inhibitors with neuroprotective role for Alzheimer's disease.
AID1113095	Antioxidant activity assessed as DPPH radical scavenging activity at 0.8 mg/ml after 30 min by spectrophotometric analysis	2013	Journal of agricultural and food chemistry, Mar-27, Volume: 61, Issue:12	Isolation and characterization of new p-Terphenyls with antifungal, antibacterial, and antioxidant activities from halophilic actinomycete Nocardiopsis gilva YIM 90087.
AID1687459	Antioxidant activity in human RBC assessed as increase in total antioxidant capacity level up to 400 ug/ml measured after 72 hrs relative to control	2020	European journal of medicinal chemistry, Jan-15, Volume: 186	Novel anti-Alzheimer phenol-lipoyl hybrids: Synthesis, physico-chemical characterization, and biological evaluation.
AID502062	Antioxidant activity assessed as ABTS radical scavenging activity at 400 ug/ml	2010	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17	InCl3 mediated one-pot multicomponent synthesis, anti-microbial, antioxidant and anticancer evaluation of 3-pyranyl indole derivatives.
AID1575198	Antioxidant activity assessed as DPPH free radical scavenging activity at 20 uM	2019	Bioorganic & medicinal chemistry letters, 02-01, Volume: 29, Issue:3	Aegeline, a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast.
AID1730958	Antioxidant activity assessed as DPPH radical scavenging activity at 50 ug/ml (Rvb = 22 to 40.2 %)	2021	Bioorganic & medicinal chemistry letters, 03-15, Volume: 36	Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme.
AID311562	DPPH radical scavenging activity	2007	Journal of natural products, Oct, Volume: 70, Issue:10	Isoechinulin-type alkaloids, variecolorins A-L, from halotolerant Aspergillus variecolor.
AID652743	Antioxidant activity using deaerated 1 M ethylene glycol as substrate assessed as acetaldehyde level at 1 mmol/L after gamma-irradiation by gas chromatography (Rvb = 3.24 +/- 0.19 10'7 mol/J)	2012	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7	Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
AID504289	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins	2010	Journal of natural products, Sep-24, Volume: 73, Issue:9	Chlorinated iridoid glucosides from Veronica longifolia and their antioxidant activity.
AID1347857	Inhibition of tyrosinase in human A375 cells assessed as effect on alpha-MSH-induced melanin formation at 25 uM after 24 hrs relative to control	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	Design, synthesis and evaluation of novel dihydrostilbene derivatives as potential anti-melanogenic skin-protecting agents.
AID1360875	Antioxidant activity assessed as ferric ion reduction by measuring FeSO4 equivalents reducing Fe3+-TPTZ to Fe2+-TPTZ at 100 ug/ml after 25 mins by FRAP assay	2018	European journal of medicinal chemistry, Jul-15, Volume: 155	Synthesis and biological evaluation of new coumarins bearing 2,4-diaminothiazole-5-carbonyl moiety.
AID1226439	Antioxidant activity assessed as DPPH radical scavenging activity after 1 hr	2015	Journal of medicinal chemistry, May-28, Volume: 58, Issue:10	Selenium-containing chrysin and quercetin derivatives: attractive scaffolds for cancer therapy.
AID1610481	Inhibition of human erythrocyte AChE at 20 uM using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method relative to control	2019	Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23	Synthesis of 2-arylhydrazinylidene-3-oxo-4,4,4-trifluorobutanoic acids as new selective carboxylesterase inhibitors and radical scavengers.
AID1065886	Cytotoxicity against rat primary smooth muscle cells assessed as growth inhibition under normoxic condition at 100 to 200 ug/mL measured over 4 days by WST-1 assay	2013	Journal of medicinal chemistry, Dec-27, Volume: 56, Issue:24	Controlled oxygen release from pyridone endoperoxides promotes cell survival under anoxic conditions.
AID1614269	Antioxidant activity assessed as DPPH radical scavenging activity at 20 uM incubated for 30 mins under dark condition relative to control	2019	Bioorganic & medicinal chemistry, 02-15, Volume: 27, Issue:4	Design, synthesis and identification of novel coumaperine derivatives for inhibition of human 5-LOX: Antioxidant, pseudoperoxidase and docking studies.
AID355801	Antioxidant activity against TPA-induced ROS production in human HL60 cells by 2',7'-dichlorodihydrofluorescein diacetate cellular-based assay	2003	Journal of natural products, May, Volume: 66, Issue:5	Marine natural products as novel antioxidant prototypes.
AID487438	Antioxidant activity assessed as free radical scavenging activity by lipid peroxidation assay	2010	European journal of medicinal chemistry, Jun, Volume: 45, Issue:6	Synthesis, anticancer and antioxidant activities of 7-methoxyisoflavanone and 2,3-diarylchromanones.
AID1428669	Antioxidant activity against tert-butyl hydroperoxide-induced lipoperoxidation in rat liver microsomal membranes at 100 uM preincubated for 10 mins followed by tert-butyl hydroperoxide addition measured after 60 mins by TBARS assay relative to control	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Novel flavonolignan hybrid antioxidants: From enzymatic preparation to molecular rationalization.
AID1065885	Growth promoting activity in rat primary smooth muscle cells under normoxic condition at 100 to 200 ug/mL measured over 4 days by WST-1 assay	2013	Journal of medicinal chemistry, Dec-27, Volume: 56, Issue:24	Controlled oxygen release from pyridone endoperoxides promotes cell survival under anoxic conditions.
AID486890	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins	2010	Journal of natural products, Jun-25, Volume: 73, Issue:6	Dihydro-beta-agarofuran sesquiterpenes and pentacyclic triterpenoids from the root bark of Osyris lanceolata.
AID1322144	Antioxidant activity assessed as DPPH free radical scavenging activity at 3 uM after 30 mins incubation in dark	2016	Bioorganic & medicinal chemistry, 11-01, Volume: 24, Issue:21	Thioflavones as novel neuroprotective agents.
AID754976	Inhibition of N-terminal His6-tagged human platelet 12-LOX pseudoperoxidase activity assessed as reduction of active ferric ion to inactive ferrous state measured decomposition of 13-(S)-HPODE at 40 uM after 30 mins by iron-xylenol orange staining assay	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Pseudoperoxidase investigations of hydroperoxides and inhibitors with human lipoxygenases.
AID1759523	Antioxidant activity assessed as reduction in FK506-induced ROS production by DPPH assay	2021	Bioorganic & medicinal chemistry letters, 06-01, Volume: 41	Identification of gallic acid as a active ingredient of Syzygium aromaticum against tacrolimus-induced damage in renal epithelial LLC-PK1 cells and rat kidney.
AID1882444	Antioxidant activity assessed as AAPH radical scavenging activity at 12.5 uM ORAC assay
AID427663	Antioxidant activity assessed as potassium ferric cyanide ion reducing power after 10 mins by Oyaizu method	2009	Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13	Potential antioxidants and tyrosinase inhibitors from synthetic polyphenolic deoxybenzoins.
AID1428678	Cytoprotective activity against tert-butyl hydroperoxide-induced toxicity in human HepG2 cells assessed as cell viability at 5 uM pretreated for 1 hr followed by co-treatment with tert-butyl hydroperoxide for 3 hrs by MTT assay (Rvb = 22%)	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Novel flavonolignan hybrid antioxidants: From enzymatic preparation to molecular rationalization.
AID1743662	Antioxidant activity assessed as bleomycin-Fe2+-induced DNA degradation by measuring absorbance at 0.1 mg/ml after 1 hr	2020	European journal of medicinal chemistry, Dec-15, Volume: 208	Synthesis and biological evaluation of organoselenium (NSAIDs-SeCN and SeCF
AID1555977	Selectivity index, ratio of IC50 for electric eel AChE to IC50 for equine serum BuChE	2019	European journal of medicinal chemistry, Sep-01, Volume: 177	Design, synthesis, and biological evaluation of rutacecarpine derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease.
AID1193493	Thermodynamic equilibrium solubility, log S of the compound in PBS at pH 7.4 at RT after 4 hrs by 96 well plate method	2015	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7	Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery.
AID539845	Antioxidant activity assessed as DPPH radical scavenging activity at 1000 ug by spectrophotometry relative to control	2010	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24	Synthesis, antimicrobial and antioxidant evaluation of quinolines and bis(indolyl)methanes.
AID652734	Antioxidant activity using 1M ethanol as substrate assessed as hydroxy radical additive level at 1 mmol/L after gamma-irradiation	2012	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7	Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
AID1439750	Antioxidant activity assessed as inhibition of nitric oxide radical generation at 1 mM using sodium nitroprusside after 150 mins by Griess assay relative to control	2017	Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7	Synthesis of extended conjugated indolyl chalcones as potent anti-breast cancer, anti-inflammatory and antioxidant agents.
AID298759	Antioxidant activity assessed as DPPH free radical scavenging activity	2007	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 17, Issue:5	Synthesis, structural revision, and antioxidant activities of antimutagenic homoisoflavonoids from Hoffmanosseggia intricata.
AID539843	Antioxidant activity assessed as DPPH radical scavenging activity at 50 ug by spectrophotometry relative to control	2010	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24	Synthesis, antimicrobial and antioxidant evaluation of quinolines and bis(indolyl)methanes.
AID1268017	Antioxidant activity assessed as DPPH free radical scavenging activity at 50 ug/ml after 20 mins by UV-vis spectrophotometry analysis	2016	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2	Synthesis of novel coumarin appended bis(formylpyrazole) derivatives: Studies on their antimicrobial and antioxidant activities.
AID719014	Antioxidant activity of compound assessed as ferric reducing antioxidant power	2012	Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24	Novel coumarin derivatives bearing N-benzyl pyridinium moiety: potent and dual binding site acetylcholinesterase inhibitors.
AID597947	Antioxidant activity assessed as DPPH radical scavenging activity after 10 mins	2011	Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11	Monoterpenoids from the aerial parts of Aruncus dioicus var. kamtschaticus and their antioxidant and cytotoxic activities.
AID1730965	Antioxidant activity assessed as hydrogen peroxide radical scavenging activity at 25 ug/ml (Rvb = 23.6 to 43.1 %)	2021	Bioorganic & medicinal chemistry letters, 03-15, Volume: 36	Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme.
AID1267471	Antioxidant activity assessed as DPPH radical scavenging activity at 0.05 mM after 30 mins	2016	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1	Bioactive minor components of the total salvianolic acids injection prepared from Salvia miltiorrhiza Bge.
AID439061	Antioxidant activity assessed as inhibition of xanthine/xanthine oxidase system-induced superoxide anion radical scavenging activity after 20 mins	2009	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 19, Issue:21	Glucose-containing flavones--their synthesis and antioxidant and neuroprotective activities.
AID652738	Antioxidant activity using deaerated 1 M ethanol as substrate assessed as acetaldehyde level at 1 mmol/L after gamma-irradiation by gas chromatography (Rvb = 0.18 +/- 0.04 10'7 mol/J)	2012	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7	Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
AID536047	Antioxidant activity assessed as beta-carotene bleaching activity at 24 uM after 4 hrs by spectrophotometry relative to control	2010	Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22	Synthesis and antioxidant properties of pulvinic acids analogues.
AID1511012	Antioxidant activity assessed as H2O2 radical scavenging activity	2019	European journal of medicinal chemistry, Oct-15, Volume: 180	Discovery of new potent dual sigma receptor/GluN2b ligands with antioxidant property as neuroprotective agents.
AID417458	Protection against bleomycin-induced damage in calf thymus type 1 DNA assessed as absorbance at 532 nm after 1 hr	2009	European journal of medicinal chemistry, Feb, Volume: 44, Issue:2	Design and synthesis of azolopyrimidoquinolines, pyrimidoquinazolines as anti-oxidant, anti-inflammatory and analgesic activities.
AID625679	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by micro plate reader	2011	European journal of medicinal chemistry, Nov, Volume: 46, Issue:11	L-Proline anchored multicomponent synthesis of novel pyrido[2,3-a]carbazoles; investigation of in vitro antimicrobial, antioxidant, cytotoxicity and structure activity relationship studies.
AID379523	Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins by multilabel counter	2006	Journal of natural products, Nov, Volume: 69, Issue:11	Terpenoids and a diarylheptanoid from Zingiber ottensii.
AID1428667	Antioxidant activity against tert-butyl hydroperoxide-induced lipoperoxidation in rat liver microsomal membranes at 1 mM preincubated for 10 mins followed by tert-butyl hydroperoxide addition measured after 60 mins by TBARS assay relative to control	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Novel flavonolignan hybrid antioxidants: From enzymatic preparation to molecular rationalization.
AID1125420	Antioxidant activity assessed as total antioxidant capacity by absorbance analysis	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Two sarcoviolins with antioxidative and α-glucosidase inhibitory activity from the edible mushroom Sarcodon leucopus collected in Tibet.
AID1611503	Antioxidant activity assessed as DPPH free radical scavenging activity at 100 uM incubated for 60 mins by spectrophotometric method relative to control	2019	Bioorganic & medicinal chemistry letters, 12-15, Volume: 29, Issue:24	Synthesis and evaluation of 1,3,5-triazine derivatives as sunscreens useful to prevent skin cancer.
AID652741	Antioxidant activity using deaerated 3 M ethylene glycol as substrate assessed as acetaldehyde level at 1 mmol/L after gamma-irradiation by gas chromatography (Rvb = 9.05 +/- 1.03 10'7 mol/J)	2012	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7	Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
AID1639036	Antioxidant activity assessed as increase in total ferric ion reducing activity at 1000 uM using FeCl3.6H2O and TPTZ incubated for 10 mins under dark condition by FRAP assay relative to control	2019	Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7	Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies.
AID1313283	Antioxidant activity assessed as DPPH radical scavenging activity at 100 ug/ml after 20 mins by spectrophotometry relative to control	2016	Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15	Synthesis of lignan conjugates via cyclopropanation: Antimicrobial and antioxidant studies.
AID1303222	Antioxidant activity assessed as DPPH scavenging activity at 60 ug/ml and 120 degC after 4 hrs by spectrophotometric method	2016	Bioorganic & medicinal chemistry letters, 06-01, Volume: 26, Issue:11	Increase of rutin antioxidant activity by generating Maillard reaction products with lysine.
AID1198760	Antioxidant activity assessed as ROO. radical scavenging activity by TRAP assay	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and assessment of the antioxidant and antitumor properties of asymmetric curcumin analogues.
AID753134	Antioxidant activity assessed as Fe2+ formation by FRAP assay	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and evaluation of 4-substituted coumarins as novel acetylcholinesterase inhibitors.
AID330319	Increase in hepatitis C virus replication in Huh7-K2040 cells in presence of delipidated fetal calf serum medium at 0.3 uM by RT-PCR relative to control	2007	Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47	Inhibition of hepatitis C virus replication by peroxidation of arachidonate and restoration by vitamin E.
AID1238058	Antioxidant activity incubated at 50 degC for 20 mins by FRAP assay	2015	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16	Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives.
AID1194984	Antioxidant activity assessed as FRAP values at 25 ug/ml incubated at 37 degC for 5 mins by FeSO4.7H2O calibration curve based method	2015	Bioorganic & medicinal chemistry letters, , Volume: 25, Issue:10	Cytotoxic and antioxidant constituents from the leaves of Psidium guajava.
AID722252	Antioxidant activity assessed as DPPH radical scavenging activity in ethanol solution at 5 ug/mL	2013	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 23, Issue:3	Synthesis and antioxidant activity of thymol and carvacrol based Schiff bases.
AID1810904	Binding affinity to human serum BChE assessed as half life
AID549276	Cytotoxicity against human HS68 cells up to 100 ug/ml after 72 hrs by MTT assay	2010	Journal of natural products, Nov-29, Volume: 73, Issue:11	Inhibition of melanogenesis and oxidation by protocatechuic acid from Origanum vulgare (oregano).
AID1309173	Antioxidant activity assessed as AAPH radical scavenging activity preincubated for 30 mins followed by AAPH addition measured after 60 mins by ORAC assay	2016	Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16	Ionophoric polyphenols selectively bind Cu(2+), display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila.
AID1198759	Antioxidant activity assessed as ABTS radical scavenging activity by spectrophotometry	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and assessment of the antioxidant and antitumor properties of asymmetric curcumin analogues.
AID1496216	Antioxidant activity assessed as DPPH free radical scavenging activity at 6.25 uM after 30 mins in dark by spectrophotometric method relative to control	2018	Bioorganic & medicinal chemistry letters, 07-01, Volume: 28, Issue:12	Valproic acid induces three novel cytotoxic secondary metabolites in Diaporthe sp., an endophytic fungus from Datura inoxia Mill.
AID594173	Antioxidant activity assessed as ABTS radical scavenging activity at 2 mM	2011	European journal of medicinal chemistry, May, Volume: 46, Issue:5	Synthesis, antimicrobial, antioxidant, anti-hemolytic and cytotoxic evaluation of new imidazole-based heterocycles.
AID1430036	Antioxidant activity assessed as inhibition of DDQ radical by spectrophotometric method	2017	Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5	Synthesis of new chromeno-carbamodithioate derivatives and preliminary evaluation of their antioxidant activity and molecular docking studies.
AID762738	Antioxidant activity assessed as reducing power of ferric ion at 100 ug/ml after 20 mins	2013	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 23, Issue:16	Novel pyrazoline amidoxime and their 1,2,4-oxadiazole analogues: synthesis and pharmacological screening.
AID396446	Anti-aging activity in human dermal fibroblasts assessed as expression rate of procollagen type 1 formation at 200 uM relative to control	2009	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2	Synthesis and in vitro biological activity of retinyl polyhydroxybenzoates, novel hybrid retinoid derivatives.
AID1113092	Antioxidant activity assessed as ABTS radical scavenging activity at 0.16 mg/ml after 5 min by spectrophotometric analysis	2013	Journal of agricultural and food chemistry, Mar-27, Volume: 61, Issue:12	Isolation and characterization of new p-Terphenyls with antifungal, antibacterial, and antioxidant activities from halophilic actinomycete Nocardiopsis gilva YIM 90087.
AID1173789	Antioxidant activity assessed as DPPH radical scavenging activity after 3 hrs by spectrophotometry	2014	Bioorganic & medicinal chemistry, Dec-01, Volume: 22, Issue:23	Antioxidant and antimicrobial studies on fused-ring pyrazolones and isoxazolones.
AID1496215	Antioxidant activity assessed as DPPH free radical scavenging activity at 12.5 uM after 30 mins in dark by spectrophotometric method relative to control	2018	Bioorganic & medicinal chemistry letters, 07-01, Volume: 28, Issue:12	Valproic acid induces three novel cytotoxic secondary metabolites in Diaporthe sp., an endophytic fungus from Datura inoxia Mill.
AID349360	Antioxidant activity assessed as inhibition of ROS-induced linoleic acid peroxidation at 2 mM after 15 mins at 100 degC by modified TBARS assay relative to control	2008	Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19	Antioxidative and thrombolytic TMP nitrone for treatment of ischemic stroke.
AID389190	Antioxidant activity assessed as oxygen radical absorbance capacity index value by fluorescein protection assay	2008	Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20	Antioxidant capacity of human blood plasma and human urine: simultaneous evaluation of the ORAC index and ascorbic acid concentration employing pyrogallol red as probe.
AID637943	Antioxidant activity assessed as inhibition of superoxide anion scavenging activity at 1 mg after 60 mins by spectrophotometric analysis	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Design and diversity-oriented synthesis of novel 1,4-thiazepan-3-ones fused with bioactive heterocyclic skeletons and evaluation of their antioxidant and cytotoxic activities.
AID761968	Antioxidant activity assessed as superoxide radical scavenging activity after 5 mins by spectrophotometry	2013	European journal of medicinal chemistry, Aug, Volume: 66	Novel 2-(2,4-dioxo-1,3-thiazolidin-5-yl)acetamides as antioxidant and/or anti-inflammatory compounds.
AID1610133	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Dec-15, Volume: 184	Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives.
AID496823	Antimicrobial activity against Trichomonas vaginalis	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
AID497005	Antimicrobial activity against Pneumocystis carinii	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
AID294913	Antioxidant activity assessed as nitric oxide radical scavenging activity at 0.2 ug/ml after 150 mins	2007	European journal of medicinal chemistry, Aug, Volume: 42, Issue:8	Syntheses of new tetrasubstituted thiophenes as novel anti-inflammatory agents.
AID977599	Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM	2013	Molecular pharmacology, Jun, Volume: 83, Issue:6	Structure-based identification of OATP1B1/3 inhibitors.
AID1917388	Antioxidant activity in UV-B irradiation induced human HDF cells assessed as decrease in ROS level at 25 uM incubated for 6 hrs by fluorescence microscopy	2022	Bioorganic & medicinal chemistry letters, 11-15, Volume: 76	Photoprotective effect of 18β-glycyrrhetinic acid derivatives against ultra violet (UV)-B-Induced skin aging.
AID1655202	Antioxidant activity in pH 7.4 PBS assessed as H2O2 radical scavenging activity	2020	ACS medicinal chemistry letters, May-14, Volume: 11, Issue:5	Synthesis, Cytotoxicity Evaluation, and Computational Insights of Novel 1,4-Diazepane-Based Sigma Ligands.
AID614057	Inhibition of bovine testes hyaluronidase at 170 uM after 30 mins at pH 5 by turbidimetric analysis	2011	European journal of medicinal chemistry, Sep, Volume: 46, Issue:9	Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase.
AID536052	Antioxidant activity assessed as DPPH free radical scavenging activity by measuring [DPPH]/antioxidant EC50 ratio measured every 5 mins for 1 hr	2010	Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22	Synthesis and antioxidant properties of pulvinic acids analogues.
AID1557190	Antioxidant activity assessed as reduction of Cu2+ in bis-neocuproine-Cu2+ complex to bis-neocuproine-Cu+ complex measured as trolox equivalent antioxidant capacity incubated for 30 mins by CUPRAC assay	2019	Bioorganic & medicinal chemistry letters, 10-01, Volume: 29, Issue:19	Heterocyclic β-keto sulfide derivatives of carvacrol: Synthesis and copper (II) ion reducing capacity.
AID1065897	Growth promoting activity in rat 3T3 cells under anoxic condition at 500 ug/mL measured on day 1 by WST-1 assay	2013	Journal of medicinal chemistry, Dec-27, Volume: 56, Issue:24	Controlled oxygen release from pyridone endoperoxides promotes cell survival under anoxic conditions.
AID380429	Cytotoxicity against human BT549 cells upto 48 uM	2006	Journal of natural products, Mar, Volume: 69, Issue:3	Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans.
AID437943	Inhibition of superoxide dismutase in Wistar rat brain	2010	European journal of medicinal chemistry, Jan, Volume: 45, Issue:1	Synthesis, spectral characterization and biological evaluation of phosphorylated derivatives of galanthamine.
AID497112	Antioxidant activity assessed as ABTS free radical scavenging activity after 12 hrs	2010	Bioorganic & medicinal chemistry, Aug-01, Volume: 18, Issue:15	Synthesis and biological evaluation of arylidene analogues of Meldrum's acid as a new class of antimalarial and antioxidant agents.
AID666939	Antioxidant activity assessed as DPPH radical scavenging activity at 10 ug/ml after 30 mins by spectrophotometry	2012	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13	Evaluation of novel antioxidant triterpenoid saponins from the halophyte Salicornia herbacea.
AID1565353	Antioxidant activity assessed as DPPH radical scavenging activity incubated for 20 mins by spectrophotometric method	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Cyclic enaminone as new chemotype for selective cyclooxygenase-2 inhibitory, anti-inflammatory, and analgesic activities.
AID496828	Antimicrobial activity against Leishmania donovani	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
AID1533609	Antioxidant activity assessed as DPPH radical scavenging activity at 10 uM after 30 mins under dark condition relative to control	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Design and development of some phenyl benzoxazole derivatives as a potent acetylcholinesterase inhibitor with antioxidant property to enhance learning and memory.
AID504291	Antioxidant activity assessed as nitric oxide scavenging activity after 150 mins by Griess assay	2010	Journal of natural products, Sep-24, Volume: 73, Issue:9	Chlorinated iridoid glucosides from Veronica longifolia and their antioxidant activity.
AID1581628	Antioxidant activity assessed as inhibition of H2O2 radical scavenging activity incubated for 60 mins by UV-spectrophotometric method	2020	European journal of medicinal chemistry, Feb-01, Volume: 187	Synthesis and discovery of triazolo-pyridazine-6-yl-substituted piperazines as effective anti-diabetic drugs; evaluated over dipeptidyl peptidase-4 inhibition mechanism and insulinotropic activities.
AID620059	Antioxidant activity assessed as hydrogen peroxide scavenging activity at 75 ug/ml relative to control	2011	European journal of medicinal chemistry, Oct, Volume: 46, Issue:10	Synthesis and antioxidant activity of oxazolyl/thiazolylsulfonylmethyl pyrazoles and isoxazoles.
AID1443229	Antioxidant activity assessed as DPPH radical scavenged per mole of compound after 20 mins	2017	Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8	Chemical synthesis, redox transformation, and identification of sonnerphenolic C, an antioxidant in Acer nikoense.
AID1383667	Antioxidant activity assessed as DPPH radical scavenging activity at 20 uM after 25 mins	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Development of Piperazinediones as dual inhibitor for treatment of Alzheimer's disease.
AID1405930	Antioxidant activity assessed as DPPH radical scavenging activity at 100 mM after 30 mins relative to control	2018	European journal of medicinal chemistry, Aug-05, Volume: 156	Current progress on antioxidants incorporating the pyrazole core.
AID502054	Antioxidant activity assessed as DPPH radical scavenging activity at 50 ug/ml	2010	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17	InCl3 mediated one-pot multicomponent synthesis, anti-microbial, antioxidant and anticancer evaluation of 3-pyranyl indole derivatives.
AID496827	Antimicrobial activity against Leishmania amazonensis	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
AID375991	Antioxidant activity assessed as inhibition of 2,2'-azobis(2-amidinopropane)dihydrochloride-induced lipid peroxidation at 3.125 ug/ml by ferric thiocyanate system relative to control	2006	Journal of natural products, Apr, Volume: 69, Issue:4	Vanillic acid glycoside and quinic acid derivatives from Gardeniae Fructus.
AID298758	Antioxidant activity assessed as superoxide scavenging activity by NBT reduction assay	2007	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 17, Issue:5	Synthesis, structural revision, and antioxidant activities of antimutagenic homoisoflavonoids from Hoffmanosseggia intricata.
AID437808	Antioxidant activity assessed as hydroxyl free radical scavenging activity at 1 mg assessed per mg	2009	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19	Green chemoselective synthesis of thiazolo[3,2-a]pyridine derivatives and evaluation of their antioxidant and cytotoxic activities.
AID375988	Antioxidant activity assessed as DPPH free radical scavenging activity relative to control	2006	Journal of natural products, Apr, Volume: 69, Issue:4	Vanillic acid glycoside and quinic acid derivatives from Gardeniae Fructus.
AID1352200	Inhibition of soybean 15-LOX using arachidonic acid or linoleic acid as substrate preincubated with enzyme followed by substrate addition up to 5 mins by chromogenic method	2018	European journal of medicinal chemistry, Feb-10, Volume: 145	Design, synthesis, biological evaluation and docking studies of new 3-(4,5-dihydro-1H-pyrazol/isoxazol-5-yl)-2-phenyl-1H-indole derivatives as potent antioxidants and 15-lipoxygenase inhibitors.
AID1565348	Antioxidant activity assessed as DPPH radical scavenging activity at 20 uM/ml incubated for 20 mins by spectrophotometric method relative to control	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Cyclic enaminone as new chemotype for selective cyclooxygenase-2 inhibitory, anti-inflammatory, and analgesic activities.
AID614098	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by spectrophotometric analysisic analysis	2011	Bioorganic & medicinal chemistry, Sep-01, Volume: 19, Issue:17	Tylosema esculentum extractives and their bioactivity.
AID1202776	Antioxidant activity assessed as trolox equivalent of ABTS radical scavenging activity after 10 mins by hydrophilic-TEAC fluorescence assay	2015	Journal of natural products, Feb-27, Volume: 78, Issue:2	Antioxidative compounds from Garcinia buchananii stem bark.
AID1233697	Antioxidant activity assessed as AAPH radical scavenging activity by measuring Trolox equivalents after 90 mins by fluorescein probe based ORAC assay	2015	European journal of medicinal chemistry, Jul-15, Volume: 100	1,5-Diarylpyrazole and vanillin hybrids: Synthesis, biological activity and DFT studies.
AID1399480	Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate incubated for 10 mins followed by substrate addition by Ellman's method	2018	Bioorganic & medicinal chemistry, 09-01, Volume: 26, Issue:16	Synthesis, molecular docking, and biological activity of 2-vinyl chromones: Toward selective butyrylcholinesterase inhibitors for potential Alzheimer's disease therapeutics.
AID536048	Antioxidant activity assessed as beta-carotene bleaching activity at 116 uM after 4 hrs by spectrophotometry relative to contro	2010	Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22	Synthesis and antioxidant properties of pulvinic acids analogues.
AID744462	Antioxidant activity of the compound assessed as DPPH free radical scavenging activity at 125 uM after 60 mins by spectrophotometric analysis relative to control	2013	European journal of medicinal chemistry, May, Volume: 63	Synthesis and biological activities of some novel aminomethyl derivatives of 4-substituted-5-(2-thienyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones.
AID1487484	Antioxidant activity assessed as DPPH free radical scavenging activity at 80 ug/ml after 15 mins by spectrophotometric method	2017	Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16	Synthesis, antioxidant, antifungal, molecular docking and ADMET studies of some thiazolyl hydrazones.
AID720996	Antioxidant activity assessed as hydroxyl radical scavenging activity after 1 hr by spectrophotometry	2013	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1	Synthesis and antioxidant activities of 2-oxo-quinoline-3-carbaldehyde Schiff-base derivatives.
AID764765	Antioxidant activity assessed as DPPH radical scavenging activity at 40 uM after 30 mins	2013	Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17	Design, synthesis and pharmacological evaluation of (E)-3,4-dihydroxy styryl sulfonamides derivatives as multifunctional neuroprotective agents against oxidative and inflammatory injury.
AID1549510	Antioxidant activity assessed as DPPH radical scavenging activity incubated in dark for 30 mins by spectrophotometric method relative to control	2019	European journal of medicinal chemistry, May-01, Volume: 169	Anticancer activity, dual prooxidant/antioxidant effect and apoptosis induction profile of new bichalcophene-5-carboxamidines.
AID1488290	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins in absence of light	2017	Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16	Synthesis, antioxidant and antiproliferative activities of 1,3,4-thiadiazoles derived from phenolic acids.
AID549262	Antioxidant activity assessed as DPPH radical scavenging activity at 10 ug/ml after 30 mins	2010	Journal of natural products, Nov-29, Volume: 73, Issue:11	Inhibition of melanogenesis and oxidation by protocatechuic acid from Origanum vulgare (oregano).
AID616385	Antioxidant activity assessed DPPH scavenging activity	2011	Journal of natural products, Sep-23, Volume: 74, Issue:9	Anti-inflammatory principles from Cordyceps sinensis.
AID1368751	Inhibition of NOX4 in human ARPE19 cells assessed as suppression of 4-HNE-induced superoxide production at 10 uM pre-incubated for 1 hr before 4-HNE addition for 1 hr by lucigenin chemiluminescence assay	2018	Bioorganic & medicinal chemistry letters, 01-15, Volume: 28, Issue:2	Protective effects of 6-ureido/thioureido-2,4,5-trimethylpyridin-3-ols against 4-hydroxynonenal-induced cell death in adult retinal pigment epithelial-19 cells.
AID511052	Antioxidant activity assessed as DPPH free radical scavenging activity at 100 uM after 20 mins	2010	European journal of medicinal chemistry, Sep, Volume: 45, Issue:9	Synthesis and bioassay of aminosulfonyl-1,3,4-oxadiazoles and their interconversion to 1,3,4-thiadiazoles.
AID1466637	Antioxidant activity assessed as inhibition of DPPH free radical at 50 uM after 30 mins relative to control	2017	Bioorganic & medicinal chemistry, 07-01, Volume: 25, Issue:13	Antioxidant and anticholinesterase potential of diterpenoid alkaloids from Aconitum heterophyllum.
AID497109	Antioxidant activity assessed as DPPH free radical scavenging activity at 100 uM after 1 hr	2010	Bioorganic & medicinal chemistry, Aug-01, Volume: 18, Issue:15	Synthesis and biological evaluation of arylidene analogues of Meldrum's acid as a new class of antimalarial and antioxidant agents.
AID157521	Inhibition of pancreatic alpha-amylase	1998	Bioorganic & medicinal chemistry letters, Jul-07, Volume: 8, Issue:13	Ascorbic acid-based inhibitors of alpha-amylases.
AID274158	Inhibition of bovine hyaluronidase up to 100 mM at pH 5.0	2006	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 16, Issue:20	Novel 6-O-acylated vitamin C derivatives as hyaluronidase inhibitors with selectivity for bacterial lyases.
AID1695757	Antioxidant activity assessed as DPPH radical scavenging activity at 20 uM after 30 mins under dark condition by DPPH assay relative to control	2019	Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7	Design and development of novel N-(pyrimidin-2-yl)-1,3,4-oxadiazole hybrids to treat cognitive dysfunctions.
AID1264276	Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins by spectrophotometric assay	2015	European journal of medicinal chemistry, Nov-02, Volume: 104	Synthesis and pharmacological evaluation of some new fluorine containing hydroxypyrazolines as potential anticancer and antioxidant agents.
AID764766	Antioxidant activity assessed as DPPH radical scavenging activity at 50 uM after 30 mins	2013	Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17	Design, synthesis and pharmacological evaluation of (E)-3,4-dihydroxy styryl sulfonamides derivatives as multifunctional neuroprotective agents against oxidative and inflammatory injury.
AID1901979	Antioxidant activity assessed as free radical scavenging activity incubated for 30 mins under dark condition by DPPH assay	2022	European journal of medicinal chemistry, Mar-05, Volume: 231	Discovery of novel diphenylbutene derivative ferroptosis inhibitors as neuroprotective agents.
AID1487487	Antioxidant activity assessed as H2O2 free radical scavenging activity at 20 ug/ml after 10 to 15 mins by spectrophotometric analysis	2017	Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16	Synthesis, antioxidant, antifungal, molecular docking and ADMET studies of some thiazolyl hydrazones.
AID453285	Reducing activity assessed as reduction of ferric ion by reducing power assay	2009	Bioorganic & medicinal chemistry, Oct-15, Volume: 17, Issue:20	Synthesis and antioxidant properties of new chromone derivatives.
AID597946	Cytotoxicity against human Jurkat T cells after 36 hrs by MTT assay	2011	Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11	Monoterpenoids from the aerial parts of Aruncus dioicus var. kamtschaticus and their antioxidant and cytotoxic activities.
AID1156819	Antioxidant activity assessed as DPPH free radical scavenging activity	2014	European journal of medicinal chemistry, Aug-18, Volume: 83	Synthesis of α, β-unsaturated carbonyl based compounds as acetylcholinesterase and butyrylcholinesterase inhibitors: characterization, molecular modeling, QSAR studies and effect against amyloid β-induced cytotoxicity.
AID1391580	Antioxidant activity assessed as DPPH radical scavenging activity up to 0.6 mg/ml after 30 mins by absorbance method relative to control	2018	Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9	Structural analysis and antioxidant activity of the glycoside from Imperial Chrysanthemum.
AID27839	Compound was evaluated for its partition between n-octanol and water(pH 7)	2002	Journal of medicinal chemistry, Jan-17, Volume: 45, Issue:2	Synthesis and characterization of a series of novel monoacylated ascorbic acid derivatives, 6-O-acyl-2-O-alpha-D-glucopyranosyl-L-ascorbic acids, as skin antioxidants.
AID1399484	Inhibition of porcine liver carboxylesterase using 4-nitrophenol acetate as substrate incubated for 10 mins followed by substrate addition by spectrophotometric method	2018	Bioorganic & medicinal chemistry, 09-01, Volume: 26, Issue:16	Synthesis, molecular docking, and biological activity of 2-vinyl chromones: Toward selective butyrylcholinesterase inhibitors for potential Alzheimer's disease therapeutics.
AID657573	Antioxidant activity assessed as DPPH radical scavenging activity by densitometric analysis	2012	Bioorganic & medicinal chemistry, May-01, Volume: 20, Issue:9	Bioconversion of silybin to phase I and II microbial metabolites with retained antioxidant activity.
AID1599717	Antioxidant activity assessed as hydroxyl radical scavenging activity incubated for 1 hr by spectrophotometric analysis	2019	Bioorganic & medicinal chemistry, 10-15, Volume: 27, Issue:20	Synthesis of N-hydroxycinnamoyl amide derivatives and evaluation of their anti-oxidative and anti-tyrosinase activities.
AID1155576	Antioxidant activity assessed as DPPH free radical scavenging activity at 10 uM after 30 mins by UPLC-MS/MS analysis by spectrophotometric analysis	2014	Journal of medicinal chemistry, Jul-10, Volume: 57, Issue:13	SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
AID600559	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins	2011	European journal of medicinal chemistry, May, Volume: 46, Issue:5	Antiprotozoal activity of chloroquinoline based chalcones.
AID386937	Antioxidant activity assessed as superoxide radical scavenging activity at 0.40 mg/mL	2008	European journal of medicinal chemistry, Oct, Volume: 43, Issue:10	The antioxidant activity of 2-(4(or 2)-hydroxyl-5-chloride-1,3-benzene-di-sulfanimide)-chitosan.
AID568567	Antioxidant activity assessed as DPPH radical scavenging activity	2011	Journal of natural products, Jan-28, Volume: 74, Issue:1	Radical scavenging and antioxidant activities of isocoumarins and a phthalide from the endophytic fungus Colletotrichum sp.
AID1264279	Antioxidant activity assessed as DPPH free radical scavenging activity at 50 ug/ml after 30 mins by spectrophotometric assay	2015	European journal of medicinal chemistry, Nov-02, Volume: 104	Synthesis and pharmacological evaluation of some new fluorine containing hydroxypyrazolines as potential anticancer and antioxidant agents.
AID644032	Antioxidant activity assessed as DPPH free radical scavenging activity at 500 ug by spectrophotometer	2012	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 22, Issue:3	An efficient synthesis of highly functionalized novel chromeno[4,3-b]pyrroles and indolizino[6,7-b]indoles as potent antimicrobial and antioxidant agents.
AID614059	Inhibition of bovine testes hyaluronidase at 400 uM after 30 mins at pH 5 by turbidimetric analysis	2011	European journal of medicinal chemistry, Sep, Volume: 46, Issue:9	Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase.
AID615293	Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins	2011	European journal of medicinal chemistry, May, Volume: 46, Issue:5	Synthesis and bio-activity evaluation of tetraphenyl(phenylamino) methylene bisphosphonates as antioxidant agents and as potent inhibitors of osteoclasts in vitro.
AID1453054	Antioxidant activity assessed as inhibition of DPPH radical generation at 0.03 mg/ml after 20 mins under dark condition by UV-Visible spectrophotometric analysis relative to control	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Synthesis, characterization, molecular docking and in vitro antimalarial properties of new carboxamides bearing sulphonamide.
AID1487488	Antioxidant activity assessed as H2O2 free radical scavenging activity at 40 ug/ml after 10 to 15 mins by spectrophotometric analysis	2017	Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16	Synthesis, antioxidant, antifungal, molecular docking and ADMET studies of some thiazolyl hydrazones.
AID1155649	Neuroprotective activity against amyloid beta (25 to 35)-induced cell death in human SH-SY5Y cells assessed as cell viability at 2 uM after 24 hrs by MTT assay relative to control	2014	Journal of natural products, Jun-27, Volume: 77, Issue:6	Lignans from the fruit of Schisandra glaucescens with antioxidant and neuroprotective properties.
AID1486134	Antioxidant activity assessed as ABTS radical cation scavenging activity by measuring trolox equivalent antioxidant capacity after 1 hr by UV/Vis spectrophotometric analysis	2017	Bioorganic & medicinal chemistry, 08-01, Volume: 25, Issue:15	Synthesis, molecular docking, and biological activity of polyfluoroalkyl dihydroazolo[5,1-c][1,2,4]triazines as selective carboxylesterase inhibitors.
AID1377036	Antioxidant activity assessed as DPPH radical scavenging activity at test compound/DPPH volume ratio 3:1 incubated under dark condition for 30 mins by spectrophotometric method	2017	Journal of natural products, 06-23, Volume: 80, Issue:6	Derivatives of the Lignan 7'-Hydroxymatairesinol with Antioxidant Properties and Enhanced Lipophilicity.
AID549266	Antioxidant activity assessed as trolox equivalent of ABTS radical scavenging activity after 12 to 16 hrs	2010	Journal of natural products, Nov-29, Volume: 73, Issue:11	Inhibition of melanogenesis and oxidation by protocatechuic acid from Origanum vulgare (oregano).
AID1202775	Antioxidant activity assessed as trolox equivalent of APPH radical scavenging activity preincubated for 30 mins followed by APPH addition measured after 90 mins by lipophilic-ORAC fluorescence assay	2015	Journal of natural products, Feb-27, Volume: 78, Issue:2	Antioxidative compounds from Garcinia buchananii stem bark.
AID183770	Effect of AOS scavenger on arrhythmias induced by ischemia-reperfusion in anesthetized rat measured as ventricular tachycardia (VT), incidence at 3 mg/kg; 6/6	1988	Journal of medicinal chemistry, Apr, Volume: 31, Issue:4	Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID1635493	Antioxidant activity assessed as DPPH free radical scavenging activity at 20 uM after 30 secs by spectrophotometry	2016	Journal of medicinal chemistry, 06-23, Volume: 59, Issue:12	Benzylpiperidine-Linked Diarylthiazoles as Potential Anti-Alzheimer's Agents: Synthesis and Biological Evaluation.
AID387150	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins	2008	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18	ortho-dihydroxyisoflavone derivatives from aged Doenjang (Korean fermented soypaste) and its radical scavenging activity.
AID195223	The compound was tested for the inhibition of lipid peroxidation in rat liver microsomes induced by [Fe3+] at a concentration of 10E-5 M; NT indicates not tested	1991	Journal of medicinal chemistry, Jul, Volume: 34, Issue:7	3-O-alkylascorbic acids as free-radical quenchers: synthesis and inhibitory effect on lipid peroxidation.
AID637944	Antioxidant activity assessed as inhibition of hydroxyl free radical scavenging activity at 1 mg after 60 mins by spectrophotometric analysis	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Design and diversity-oriented synthesis of novel 1,4-thiazepan-3-ones fused with bioactive heterocyclic skeletons and evaluation of their antioxidant and cytotoxic activities.
AID1075443	Antioxidant activity assessed as inhibition of DPPH free radical scavenging activity	2014	Journal of medicinal chemistry, Feb-27, Volume: 57, Issue:4	Structural modifications of neuroprotective anti-Parkinsonian (-)-N6-(2-(4-(biphenyl-4-yl)piperazin-1-yl)-ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine (D-264): an effort toward the improvement of in vivo efficacy of the parent molecule.
AID427665	Antioxidant activity assessed as DPPH radical scavenging activity incubated at 40 degC in dark after 30 mins	2009	Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13	Potential antioxidants and tyrosinase inhibitors from synthetic polyphenolic deoxybenzoins.
AID567051	Antioxidant activity assessed as inhibition of linoleic acid peroxidation at 0.1 mM by AAPH assay	2011	European journal of medicinal chemistry, Jan, Volume: 46, Issue:1	Design, synthesis and pharmacobiological evaluation of novel acrylic acid derivatives acting as lipoxygenase and cyclooxygenase-1 inhibitors with antioxidant and anti-inflammatory activities.
AID1257011	Antioxidant activity assessed as DPPH radical scavenging activity after 25 mins by UV-Visible spectrophotometric analysis	2015	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 25, Issue:23	Chrysin-benzothiazole conjugates as antioxidant and anticancer agents.
AID1454104	Inhibition of Agaricus bisporus tyrosinase assessed as reduction in diphenolase activity by measuring L-DOPA oxidation after 30 mins	2017	Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15	Thiosemicarbazones as inhibitors of tyrosinase enzyme.
AID762898	Total antioxidant capacity of the compound at 50 uM relative to control	2013	Journal of natural products, Aug-23, Volume: 76, Issue:8	Phaeolschidins A-E, five hispidin derivatives with antioxidant activity from the fruiting body of Phaeolus schweinitzii collected in the Tibetan Plateau.
AID567789	Toxicity in rat erythrocytes assessed as hemolysis at 2 mM	2011	European journal of medicinal chemistry, Jan, Volume: 46, Issue:1	Cytotoxic and protective DNA damage of three new diterpenoids from the brown alga Dictoyota dichotoma.
AID274168	Inhibition of Streptococcus pneumoniae hyaluronidase	2006	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 16, Issue:20	Novel 6-O-acylated vitamin C derivatives as hyaluronidase inhibitors with selectivity for bacterial lyases.
AID1246492	Antioxidant activity assessed as H2O2 scavenging activity	2015	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19	Synthesis and biological evaluation of new symmetric curcumin derivatives.
AID1877875	Antioxidant activity assessed as DPPH radical scavenging activity
AID464440	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by spectrophotometry	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis of new spiroindolinones incorporating a benzothiazole moiety as antioxidant agents.
AID1250856	Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins in dark condition by spectrophotometric analysis	2015	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20	New arylalkanones from Horsfieldia macrobotrys, effective antidiabetic agents concomitantly inhibiting α-glucosidase and free radicals.
AID334586	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by spectrophotometry	2002	Journal of natural products, May, Volume: 65, Issue:5	2,3,4-Trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran, a novel antioxidant, from Penicillium citrinum F5.
AID292586	DPPH radical scavenging activity at 12.5 uM	2007	Journal of natural products, Jul, Volume: 70, Issue:7	Kadsuphilols A-H, oxygenated lignans from Kadsura philippinensis.
AID358943	Antioxidant activity assessed as DPPH radical scavenging activity	2001	Journal of natural products, Dec, Volume: 64, Issue:12	A quinolone alkaloid with antioxidant activity from the aleurone layer of anthocyanin-pigmented rice.
AID1730969	Antioxidant activity assessed as DPPH radical scavenging activity at 100 dilution	2021	Bioorganic & medicinal chemistry letters, 03-15, Volume: 36	Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme.
AID552063	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by ELISA	2011	Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1	Antioxidant, anti-inflammatory and anti-hyperglycaemic activities of heterocyclic homoprostanoid derivatives.
AID1882445	Cytoprotective activity against H2O2-induced oxidative injury in rat PC-12 cells assessed as cell viability at 10 uM incubated for 24 hrs (Rvb = 46.91 +/- 3.74%)
AID343716	Superoxide-scavenging activity assessed as inhibition of formation of WST1 formazan	2008	Journal of natural products, Jul, Volume: 71, Issue:7	C-geranylated chalcones from the stems of Angelica keiskei with superoxide-scavenging activity.
AID1359877	Antioxidant activity assessed as ferric ion reducing activity by measuring Fe2+ levels at 10 uM using Fe2+-TPTZ after 15 mins by FRAP assay	2018	European journal of medicinal chemistry, May-25, Volume: 152	Design, synthesis and evaluation of novel multi-target-directed ligands for treatment of Alzheimer's disease based on coumarin and lipoic acid scaffolds.
AID1178160	Antioxidant activity of the compound assessed as reduction in absorbance of DPPH after 60 mins incubation by DPPH radical scavenging /microplate assay	2014	Bioorganic & medicinal chemistry, May-01, Volume: 22, Issue:9	Synthesis, antioxidant and photoprotection activities of hybrid derivatives useful to prevent skin cancer.
AID614062	Inhibition of bovine testes hyaluronidase at 63 uM after 30 mins at pH 5 by turbidimetric analysis	2011	European journal of medicinal chemistry, Sep, Volume: 46, Issue:9	Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase.
AID614056	Inhibition of bovine testes hyaluronidase at 190 uM after 30 mins at pH 5 by turbidimetric analysis	2011	European journal of medicinal chemistry, Sep, Volume: 46, Issue:9	Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase.
AID614027	Inhibition of Streptococcus agalactiae 4755 hyaluronidase at pH 5.0 after 30 mins by turbidimetric analysis	2011	European journal of medicinal chemistry, Sep, Volume: 46, Issue:9	Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase.
AID416924	Antioxidant activity assessed as superoxide anion scavenging activity by NBT reduction method relative to Vitamin C	2009	European journal of medicinal chemistry, Feb, Volume: 44, Issue:2	Cytotoxic, antioxidant activities and structure activity relationship of some newly synthesized terpenoidal oxaliplatin analogs.
AID1155574	Inhibition of 5-LO in human neutrophils using arachidonic acid as substrate preincubated for 15 mins measured after 10 mins by HPLC analysis	2014	Journal of medicinal chemistry, Jul-10, Volume: 57, Issue:13	SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
AID714929	Antioxidant activity assessed as DPPH free radical scavenging activity by spectrophotometry	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues.
AID644033	Antioxidant activity assessed as DPPH free radical scavenging activity at 1000 ug by spectrophotometer	2012	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 22, Issue:3	An efficient synthesis of highly functionalized novel chromeno[4,3-b]pyrroles and indolizino[6,7-b]indoles as potent antimicrobial and antioxidant agents.
AID396457	Antioxidant activity assessed as free radical scavenging activity at 10 uM	2009	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2	Synthesis and in vitro biological activity of retinyl polyhydroxybenzoates, novel hybrid retinoid derivatives.
AID1743177	Antioxidant activity assessed as ABTS radical scavenging activity measured after 1 hr by UV-vis spectrophotometric method	2020	European journal of medicinal chemistry, Dec-15, Volume: 208	Multiple biological active 4-aminopyrazoles containing trifluoromethyl and their 4-nitroso-precursors: Synthesis and evaluation.
AID549277	Inhibition of tyrosinase in mouse B16 cells at 10 to 20 ug/ml after 72 hrs by spectrophotometry	2010	Journal of natural products, Nov-29, Volume: 73, Issue:11	Inhibition of melanogenesis and oxidation by protocatechuic acid from Origanum vulgare (oregano).
AID1875630	Antioxidant activity assessed as DPPH radical scavenging activity incubated for 35 mins under dark condition	2022	Journal of natural products, 11-25, Volume: 85, Issue:11	Cellular Stress-Induced Metabolites in
AID1277568	Antioxidant activity assessed as suppression of H2O2/DETAPAC-Fe2+-mediated hydroxyl radical formation by measuring oxidation of dihydrorhodamine after 5 mins by fluorescence assay	2016	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 26, Issue:4	Synthesis and biological evaluation of novel orally available 1-phenyl-6-aminouracils containing dimethyldihydrobenzofuranol structure for the treatment of allergic skin diseases.
AID1610487	Potency index, ratio of trolox IC50 to test compound IC50 for antioxidant activity assessed as decrease in ABTS radical cation scavenging activity	2019	Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23	Synthesis of 2-arylhydrazinylidene-3-oxo-4,4,4-trifluorobutanoic acids as new selective carboxylesterase inhibitors and radical scavengers.
AID1267474	Antioxidant activity assessed as DPPH radical scavenging activity at 0.125 mM after 30 mins	2016	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1	Bioactive minor components of the total salvianolic acids injection prepared from Salvia miltiorrhiza Bge.
AID693505	Antioxidant activity assessed as inhibition of DPPH free radical production after 30 mins by spectrophotometric analysis	2012	European journal of medicinal chemistry, Dec, Volume: 58	Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d]pyrimidine derivatives.
AID1272633	Antioxidant activity assessed as DPPH radical scavenging activity by measuring remaining DPPH level at 20 uM after 30 mins by plate reader analysis	2016	Bioorganic & medicinal chemistry, Feb-15, Volume: 24, Issue:4	Hydroxylated chalcones with dual properties: Xanthine oxidase inhibitors and radical scavengers.
AID1496214	Antioxidant activity assessed as DPPH free radical scavenging activity at 25 uM after 30 mins in dark by spectrophotometric method relative to control	2018	Bioorganic & medicinal chemistry letters, 07-01, Volume: 28, Issue:12	Valproic acid induces three novel cytotoxic secondary metabolites in Diaporthe sp., an endophytic fungus from Datura inoxia Mill.
AID590867	Antioxidant activity assessed as DPPH radical scavenging activity at 10 ug/mL after 30 mins	2011	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 21, Issue:8	Facile synthesis and stereochemical investigation of Mannich base derivatives: evaluation of antioxidant property and antituberculostic potency.
AID1556929	Antioxidant activity assessed as DPPH radical scavenging activity at 1 uM measured after 30 mins by spectrophotometric analysis relative to control	2019	European journal of medicinal chemistry, Oct-01, Volume: 179	Synthesis and biochemical studies of novel organic selenides with increased selectivity for hepatocellular carcinoma and breast adenocarcinoma.
AID426205	Antioxidant activity in human HL60 cells assessed as inhibition of relative oxygen species generation by DCFH-DA method	2009	Journal of natural products, Jun, Volume: 72, Issue:6	Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora.
AID515385	Antioxidant activity assessed as peroxyl radical scavenging activity assessed as trolox equivalent by spectrophotometry	2010	Bioorganic & medicinal chemistry, Sep-15, Volume: 18, Issue:18	2,3-diarylxanthones as strong scavengers of reactive oxygen and nitrogen species: a structure-activity relationship study.
AID1178156	Antioxidant activity of the compound assessed as reduction in absorbance of DPPH after 60 mins incubation at 1000 uM by DPPH radical scavenging /microplate assay	2014	Bioorganic & medicinal chemistry, May-01, Volume: 22, Issue:9	Synthesis, antioxidant and photoprotection activities of hybrid derivatives useful to prevent skin cancer.
AID1556930	Antioxidant activity assessed as ABTS radical scavenging activity at 1 mg/ml by spectrophotometric analysis relative to control	2019	European journal of medicinal chemistry, Oct-01, Volume: 179	Synthesis and biochemical studies of novel organic selenides with increased selectivity for hepatocellular carcinoma and breast adenocarcinoma.
AID652730	Antioxidant activity using ethanol as substrate assessed as H2O2 level at 1 mmol/L after gamma-irradiation by spectrophotometry (Rvb = 7.54 +/- 0.27 10'7 mol/J)	2012	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7	Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
AID1194983	Antioxidant activity assessed as FRAP values at 12.5 ug/ml incubated at 37 degC for 5 mins by FeSO4.7H2O calibration curve based method	2015	Bioorganic & medicinal chemistry letters, , Volume: 25, Issue:10	Cytotoxic and antioxidant constituents from the leaves of Psidium guajava.
AID1594063	Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins under dark condition
AID1631504	Antioxidant activity assessed as superoxide anion radical scavenging activity after 5 mins by spectrophotometric analysis	2016	Journal of natural products, Apr-22, Volume: 79, Issue:4	Minor Pyranonaphthoquinones from the Apothecia of the Lichen Ophioparma ventosa.
AID637942	Antioxidant activity assessed as inhibition of DPPH radical scavenging activity at 1 mg after 30 mins by spectrophotometric analysis	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Design and diversity-oriented synthesis of novel 1,4-thiazepan-3-ones fused with bioactive heterocyclic skeletons and evaluation of their antioxidant and cytotoxic activities.
AID437952	Antioxidant activity in Wistar rat brain assessed as glutathione content	2010	European journal of medicinal chemistry, Jan, Volume: 45, Issue:1	Synthesis, spectral characterization and biological evaluation of phosphorylated derivatives of galanthamine.
AID1309172	Ratio of resveratrol IC50 to compound IC50 for DPPH free radical scavenging activity	2016	Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16	Ionophoric polyphenols selectively bind Cu(2+), display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila.
AID1651259	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Ellman's method	2020	Bioorganic & medicinal chemistry letters, 02-15, Volume: 30, Issue:4	Design, synthesis and anti-Alzheimer's disease activity study of xanthone derivatives based on multi-target strategy.
AID387801	Radical scavenging activity in human HL-60 cells assessed as reduction of hydrogen peroxide-induced ROS generation at 30 uM administered 3 hrs before H2O2 challenge measured after 1 hr by 2',7'-dichlorofluorescein diacetate based flow cytometry	2008	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 18, Issue:19	2,2'-Pyridoin derivatives protect HL-60 cells against oxidative stress.
AID414769	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by microplate reader assay	2009	Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7	Phenolic compounds with radical scavenging and cyclooxygenase-2 (COX-2) inhibitory activities from Dioscorea opposita.
AID1762408	Antioxidant activity assessed as decrease in ABTS radical cation scavenging activity incubated for 24 hrs by UV-Vis spectrophotometric analysis	2021	European journal of medicinal chemistry, Jun-05, Volume: 218	Novel potent bifunctional carboxylesterase inhibitors based on a polyfluoroalkyl-2-imino-1,3-dione scaffold.
AID1428674	Antioxidant activity assessed as trolox equivalent of ABTS radical scavenging activity at 100 uM measured at >= 5 mins in presence of silybin	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Novel flavonolignan hybrid antioxidants: From enzymatic preparation to molecular rationalization.
AID1198761	Antioxidant activity assessed as superoxide radical scavenging activity after 5 mins by nitrotetrazolium blue chloride assay	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and assessment of the antioxidant and antitumor properties of asymmetric curcumin analogues.
AID1066680	Antioxidant activity of the compound assessed as DPPH free radical scavenging activity after 30 mins	2014	Journal of natural products, Feb-28, Volume: 77, Issue:2	Polygonumosides A-D, stilbene derivatives from processed roots of Polygonum multiflorum.
AID437807	Antioxidant activity assessed as DPPH free radical scavenging activity at 1 mg assessed per mg	2009	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19	Green chemoselective synthesis of thiazolo[3,2-a]pyridine derivatives and evaluation of their antioxidant and cytotoxic activities.
AID1743180	Antioxidant activity in human erythrocytes assessed as protection against AAPH-induced hemolysis at 50 uM preincubated for 20 mins followed by AAPH addition and measured after 2 hrs by spectrophotometric method relative to control	2020	European journal of medicinal chemistry, Dec-15, Volume: 208	Multiple biological active 4-aminopyrazoles containing trifluoromethyl and their 4-nitroso-precursors: Synthesis and evaluation.
AID762900	Total antioxidant capacity of the compound at 200 uM relative to control	2013	Journal of natural products, Aug-23, Volume: 76, Issue:8	Phaeolschidins A-E, five hispidin derivatives with antioxidant activity from the fruiting body of Phaeolus schweinitzii collected in the Tibetan Plateau.
AID1611500	Antioxidant activity assessed as DPPH free radical scavenging activity at 400 uM incubated for 60 mins by spectrophotometric method relative to control	2019	Bioorganic & medicinal chemistry letters, 12-15, Volume: 29, Issue:24	Synthesis and evaluation of 1,3,5-triazine derivatives as sunscreens useful to prevent skin cancer.
AID200332	Inhibition of salivary alpha-amylase	1998	Bioorganic & medicinal chemistry letters, Jul-07, Volume: 8, Issue:13	Ascorbic acid-based inhibitors of alpha-amylases.
AID405700	Inhibition of lipid peroxidation in renal failured rat kidney homogenate assessed as inhibition of malondialdehyde level by TBARS assay	2008	Journal of natural products, Jun, Volume: 71, Issue:6	Antioxidant 2-phenylbenzofurans and a coumestan from Lespedeza virgata.
AID1501904	Antioxidant activity assessed as inhibition of ferrous chloride-induced lipid peroxidation in DHA-PA labelled SLPC large unilamellar vesicle measured over 21 mins by fluorescence assay	2017	Journal of natural products, 09-22, Volume: 80, Issue:9	Lipid Peroxidation and Cyclooxygenase Enzyme Inhibitory Compounds from Prangos haussknechtii.
AID614050	Inhibition of bovine testes hyaluronidase at 200 uM after 30 mins at pH 5 by turbidimetric analysis	2011	European journal of medicinal chemistry, Sep, Volume: 46, Issue:9	Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase.
AID496829	Antimicrobial activity against Leishmania infantum	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
AID1246491	Antioxidant activity assessed as DPPH radical scavenging activity	2015	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19	Synthesis and biological evaluation of new symmetric curcumin derivatives.
AID1244238	Antioxidant activity assessed as inhibition of ABTS radical cation generation at 2 mM by colorimetric method relative to control	2015	European journal of medicinal chemistry, Aug-28, Volume: 101	Synthesis and biological evaluation of new curcumin analogues as antioxidant and antitumor agents: molecular modeling study.
AID594793	Antioxidant activity in rat liver homogenates assessed as inhibition of lipid peroxidation by measuring formation of thiobarbituric acid-reactive substance after 30 mins	2011	Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10	Synthesis of cinnamoyl ketoamides as hybrid structures of antioxidants and calpain inhibitors.
AID567788	Antioxidant activity in rat brain/kidney homogenates assessed as inhibition of lipid peroxidation at 2 mM by ABTS method	2011	European journal of medicinal chemistry, Jan, Volume: 46, Issue:1	Cytotoxic and protective DNA damage of three new diterpenoids from the brown alga Dictoyota dichotoma.
AID374241	Antioxidant activity assessed as inhibition of ABTS-oxidation in 0.1 M phosphate buffer at pH 7	2009	European journal of medicinal chemistry, Apr, Volume: 44, Issue:4	New acyclic nucleosides analogues as potential analgesic, anti-inflammatory, anti-oxidant and anti-microbial derived from pyrimido[4,5-b]quinolines.
AID506735	Activity of collagen prolyl 4 hydroxylase-1	2007	Nature chemical biology, Mar, Volume: 3, Issue:3	Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one?
AID1198758	Antioxidant activity assessed as DPPH radical scavenging activity by spectrophotometry	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and assessment of the antioxidant and antitumor properties of asymmetric curcumin analogues.
AID652735	Antioxidant activity using deaerated ethanol as substrate assessed as acetaldehyde level at 1 mmol/L after gamma-irradiation by gas chromatography (Rvb = 1.94 +/- 0.17 10'7 mol/J)	2012	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7	Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
AID1055052	Antioxidant activity assessed as ABTS free radical scavenging activity after 3 mins by spectrophotometry	2013	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23	Facile preparation of tetrahydro-5H-pyrido[1,2,3-de]-1,4-benzoxazines via reductive cyclization of 2-(8-quinolinyloxy)ethanones and their antioxidant activity.
AID1065899	Cytotoxicity against rat 3T3 cells assessed as growth inhibition under normoxic condition at 500 ug/mL after 2 days by WST-1 assay	2013	Journal of medicinal chemistry, Dec-27, Volume: 56, Issue:24	Controlled oxygen release from pyridone endoperoxides promotes cell survival under anoxic conditions.
AID1506524	Antioxidant activity assessed as ABTS radical scavenging activity incubated for 6 mins by spectrophotometry	2017	MedChemComm, Feb-01, Volume: 8, Issue:2	Synthesis, characterization, solubilization, cytotoxicity and antioxidant activity of aminomethylated dihydroquercetin.
AID496832	Antimicrobial activity against Trypanosoma brucei rhodesiense	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
AID506734	Activity of FIH-1	2007	Nature chemical biology, Mar, Volume: 3, Issue:3	Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one?
AID1076258	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by spectrophotometric assay	2014	European journal of medicinal chemistry, Mar-21, Volume: 75	Synthesis, docking and evaluation of antioxidant and antimicrobial activities of novel 1,2,4-triazolo[3,4-b][1,3,4]thiadiazol-6-yl)selenopheno[2,3-d]pyrimidines.
AID1202777	Antioxidant activity assessed as trolox equivalent of ABTS radical scavenging activity after 10 mins by lipophilic-TEAC fluorescence assay	2015	Journal of natural products, Feb-27, Volume: 78, Issue:2	Antioxidative compounds from Garcinia buchananii stem bark.
AID333824	Antioxidant activity against lipid peroxidation in Wistar rat brain assessed as inhibition of malondialdehyde release at 12.5 ug/mL by thiobarbituric acid method relative to control	2004	Journal of natural products, Dec, Volume: 67, Issue:12	Bioactive compounds from the seeds of Punica granatum (pomegranate).
AID294914	Antioxidant activity assessed as nitric oxide radical scavenging activity at 0.4 ug/ml after 150 mins	2007	European journal of medicinal chemistry, Aug, Volume: 42, Issue:8	Syntheses of new tetrasubstituted thiophenes as novel anti-inflammatory agents.
AID693507	Antioxidant activity assessed as inhibition of nitric oxide free radical production at 50 ug/mL after 150 mins by Griess method relative to control	2012	European journal of medicinal chemistry, Dec, Volume: 58	Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d]pyrimidine derivatives.
AID771138	Antioxidant activity assessed as DPPH radical scavenging activity at 5 to 500 uM incubated for 20 mins under dark condition by spectrophotometric analysis	2013	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 23, Issue:19	Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs).
AID294915	Antioxidant activity assessed as nitric oxide radical scavenging activity at 0.6 ug/ml after 150 mins	2007	European journal of medicinal chemistry, Aug, Volume: 42, Issue:8	Syntheses of new tetrasubstituted thiophenes as novel anti-inflammatory agents.
AID1238057	Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins under dark conditions	2015	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16	Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives.
AID722256	Antioxidant activity assessed as DPPH radical scavenging activity in ethanol solution	2013	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 23, Issue:3	Synthesis and antioxidant activity of thymol and carvacrol based Schiff bases.
AID1496212	Antioxidant activity assessed as DPPH free radical scavenging activity at 100 uM after 30 mins in dark by spectrophotometric method relative to control	2018	Bioorganic & medicinal chemistry letters, 07-01, Volume: 28, Issue:12	Valproic acid induces three novel cytotoxic secondary metabolites in Diaporthe sp., an endophytic fungus from Datura inoxia Mill.
AID1155571	Inhibition of mPGES1-mediated PGE2 production in microsomes of IL-1beta stimulated human A549 cells preincubated for 15 mins by RP-HPLC analysis	2014	Journal of medicinal chemistry, Jul-10, Volume: 57, Issue:13	SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
AID1204379	Antioxidant activity assessed as bleomycin-Fe2+-induced DNA degradation after 1 hr by spectrophotometry	2015	European journal of medicinal chemistry, Jun-05, Volume: 97	Organoselenocyanates and symmetrical diselenides redox modulators: Design, synthesis and biological evaluation.
AID1453458	Antioxidant activity of the compound in phosphate buffer at pH 6.6 assessed as potassium ferric cyanide ion reducing activity at 2.5 umol/ml after 20 mins by spectrophotometric method relative to control	2017	Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13	Synthesis of methanesulphonamido-benzimidazole derivatives as gastro-sparing antiinflammatory agents with antioxidant effect.
AID1194492	Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins by UV absorption spectrometry	2015	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 25, Issue:8	New septanoside and 20-hydroxyecdysone septanoside derivative from Atriplex portulacoides roots with preliminary biological activities.
AID1313282	Antioxidant activity assessed as DPPH radical scavenging activity at 80 ug/ml after 20 mins by spectrophotometry relative to control	2016	Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15	Synthesis of lignan conjugates via cyclopropanation: Antimicrobial and antioxidant studies.
AID1168137	Antioxidant activity assessed as DPPH free radical scavenging activity at 100 uM after 60 mins by spectrophotometry	2014	European journal of medicinal chemistry, Nov-24, Volume: 87	PASS-assisted design, synthesis and antioxidant evaluation of new butylated hydroxytoluene derivatives.
AID1462738	Antioxidant activity assessed as DPPH free radical scavenging activity by measuring retention time of AA-2G-DPPH product at 20 uM incubated for 30 mins by HPLC method	2017	Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20	Structural evidence for the DPPH radical-scavenging mechanism of 2-O-α-d-glucopyranosyl-l-ascorbic acid.
AID478247	Antioxidant activity in Wistar albino rat assessed as superoxide dismutase level	2010	European journal of medicinal chemistry, May, Volume: 45, Issue:5	Synthesis, spectral characterization and bioassay of 3,3'-(1,4-phenylene)-bis[2-alkoxycarbonyl-alkyl)-2-thio-benzoxa-phosphinines].
AID1233693	Antioxidant activity assessed as DPPH radical scavenging activity	2015	European journal of medicinal chemistry, Jul-15, Volume: 100	1,5-Diarylpyrazole and vanillin hybrids: Synthesis, biological activity and DFT studies.
AID1238056	Antioxidant activity assessed as DPPH radical scavenging activity at 200 uM incubated for 30 mins under dark conditions	2015	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16	Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives.
AID1462744	Antioxidant activity assessed as time duration for DPPH free radical scavenging activity at 20 uM by HPLC	2017	Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20	Structural evidence for the DPPH radical-scavenging mechanism of 2-O-α-d-glucopyranosyl-l-ascorbic acid.
AID738108	Antioxidant activity assessed as DPPH radical scavenging activity by by UV-vis spectrophotometry analysis	2013	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7	Antioxidant and antiproliferative activity of glycosides obtained by biotransformation of xanthohumol.
AID453278	Antioxidant activity assessed as singlet oxygen scavenging activity by fluorescent rhodamine formation assay	2009	Bioorganic & medicinal chemistry, Oct-15, Volume: 17, Issue:20	Synthesis and antioxidant properties of new chromone derivatives.
AID1288030	Antioxidant activity assessed as H2O2 scavenging activity	2016	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7	Biological evaluation and molecular docking studies of new curcuminoid derivatives: Synthesis and characterization.
AID1439749	Antioxidant activity assessed as inhibition of DPPH radical generation at 1 mM after 30 mins relative to control	2017	Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7	Synthesis of extended conjugated indolyl chalcones as potent anti-breast cancer, anti-inflammatory and antioxidant agents.
AID414770	Antioxidant activity assessed as superoxide radical scavenging activity after 20 mins by NBT reduction assay	2009	Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7	Phenolic compounds with radical scavenging and cyclooxygenase-2 (COX-2) inhibitory activities from Dioscorea opposita.
AID1594573	Antioxidant activity assessed as DPPH radical scavenging activity incubated for 15 to 20 mins by UV-visible spectrometry relative to untreated control	2019	Bioorganic & medicinal chemistry letters, 06-01, Volume: 29, Issue:11	Cu-mediated synthesis of differentially substituted diazepines as AChE inhibitors; validation through molecular docking and Lipinski's filter to develop novel anti-neurodegenerative drugs.
AID274155	Inhibition of Streptococcus agalactiae 4755 hyaluronidase at pH 5.0	2006	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 16, Issue:20	Novel 6-O-acylated vitamin C derivatives as hyaluronidase inhibitors with selectivity for bacterial lyases.
AID289320	Hydrogen peroxide scavenging activity by assessed as inhibition of lucigenin oxidation	2007	Bioorganic & medicinal chemistry, Sep-15, Volume: 15, Issue:18	2-Styrylchromones: novel strong scavengers of reactive oxygen and nitrogen species.
AID189511	Contralateral rotation produced by intrastriatal injection in rats with unilateral 6-hydroxydopamine-induced lesions of the substantia nigra at 2 microL; turns/5 min	1981	Journal of medicinal chemistry, Jun, Volume: 24, Issue:6	Synthesis and pharmacological evaluation of sulfonium analogues of dopamine: nonclassical dopamine agonists.
AID1155647	Neuroprotective activity against amyloid beta (25 to 35)-induced cell death in human SH-SY5Y cells assessed as cell viability at 0.08 uM after 24 hrs by MTT assay relative to control	2014	Journal of natural products, Jun-27, Volume: 77, Issue:6	Lignans from the fruit of Schisandra glaucescens with antioxidant and neuroprotective properties.
AID1503705	Antioxidant activity assessed as H2O2 free radical scavenging activity at IC50 after 1 hr by UV spectrophotometric analysis relative to control	2017	European journal of medicinal chemistry, Dec-01, Volume: 141	Therapeutic investigations of novel indoxyl-based indolines: A drug target validation and Structure-Activity Relationship of angiotensin-converting enzyme inhibitors with cardiovascular regulation and thrombolytic potential.
AID1730963	Antioxidant activity assessed as nitric oxide radical scavenging activity at 75 ug/ml (Rvb = 25.8 to 41.6 %)	2021	Bioorganic & medicinal chemistry letters, 03-15, Volume: 36	Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme.
AID638443	Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Maplexins, new α-glucosidase inhibitors from red maple (Acer rubrum) stems.
AID767446	Antioxidant activity assessed as ABTS free radical scavenging activity after 1 min	2013	European journal of medicinal chemistry, Sep, Volume: 67	Regioselective synthesis of phenanthrenes and evaluation of their anti-oxidant based anti-inflammatory potential.
AID588212	Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents	2010	Chemical research in toxicology, Jan, Volume: 23, Issue:1	Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
AID1333402	Antioxidant activity assessed as DPPH radical scavenging activity at 50 uM after 30 mins	2016	European journal of medicinal chemistry, Nov-29, Volume: 124	Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins.
AID506732	Activity of HIF prolyl hydroxylase-2	2007	Nature chemical biology, Mar, Volume: 3, Issue:3	Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one?
AID693510	Antioxidant activity assessed as inhibition of nitric oxide free radical production after 150 mins by Griess method	2012	European journal of medicinal chemistry, Dec, Volume: 58	Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d]pyrimidine derivatives.
AID516539	Antioxidant activity against superoxide dismutase like activity after 15 mins by NBT spectrometric assay	2010	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 20, Issue:19	Fluorinated 2'-hydroxychalcones as garcinol analogs with enhanced antioxidant and anticancer activities.
AID652739	Antioxidant activity using deaerated 1 M ethanol as substrate assessed as 2,3-butanediol level at 1 mmol/L after gamma-irradiation by gas chromatography (Rvb = 1.93 +/- 0.15 10'7 mol/J)	2012	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7	Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
AID1581627	Antioxidant activity assessed as inhibition of H2O2 radical scavenging activity incubated for 60 mins by UV-spectrophotometric method relative to control	2020	European journal of medicinal chemistry, Feb-01, Volume: 187	Synthesis and discovery of triazolo-pyridazine-6-yl-substituted piperazines as effective anti-diabetic drugs; evaluated over dipeptidyl peptidase-4 inhibition mechanism and insulinotropic activities.
AID1753661	Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins under dark condition relative to control	2021	European journal of medicinal chemistry, Jun-05, Volume: 218	New organoselenides (NSAIDs-Se derivatives) as potential anticancer agents: Synthesis, biological evaluation and in silico calculations.
AID335901	Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins	2002	Journal of natural products, Sep, Volume: 65, Issue:9	Oxidation, reduction, and methylation of carnosic acid by Nocardia.
AID614051	Inhibition of bovine testes hyaluronidase at 380 uM after 30 mins at pH 5 by turbidimetric analysis	2011	European journal of medicinal chemistry, Sep, Volume: 46, Issue:9	Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase.
AID1453053	Antioxidant activity assessed as inhibition of DPPH radical generation at 0.02 mg/ml after 20 mins under dark condition by UV-Visible spectrophotometric analysis relative to control	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Synthesis, characterization, molecular docking and in vitro antimalarial properties of new carboxamides bearing sulphonamide.
AID1156024	Antioxidant activity assessed as ferric ion reducing activity using fe3+-TPTZ measured per gram of protein by FRAP assay	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis and anti-cholinesterase activity of new 7-hydroxycoumarin derivatives.
AID762739	Antioxidant activity assessed as reducing power of ferric ion at 10 ug/ml after 20 mins	2013	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 23, Issue:16	Novel pyrazoline amidoxime and their 1,2,4-oxadiazole analogues: synthesis and pharmacological screening.
AID1360872	Antioxidant activity assessed as ferric ion reduction by measuring FeSO4 equivalents reducing Fe3+-TPTZ to Fe2+-TPTZ at 20 ug/ml after 25 mins by FRAP assay	2018	European journal of medicinal chemistry, Jul-15, Volume: 155	Synthesis and biological evaluation of new coumarins bearing 2,4-diaminothiazole-5-carbonyl moiety.
AID1418659	Antioxidant activity assessed as DPPH-radical scavenging activity at 1 mM incubated for 30 mins under dark condition	2018	Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21	Design, synthesis and anti-melanogenic effect of cinnamamide derivatives.
AID1610137	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Dec-15, Volume: 184	Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives.
AID1255365	Antioxidant activity assessed as ferric ion reducing activity using fe3+-TPTZ assessed as fe2+-TPTZ formation after 30 mins by FRAP assay	2015	European journal of medicinal chemistry, Oct-20, Volume: 103	Correlation of antioxidant activities with theoretical studies for new hydrazone compounds bearing a 3,4,5-trimethoxy benzyl moiety.
AID590697	Antioxidant activity against nitric oxide scavenging activity at 100 uM after 120 mins by spectrophotometric analysis at pH 7.4	2011	European journal of medicinal chemistry, Apr, Volume: 46, Issue:4	Synthesis and biological activity of 2-(bis((1,3,4-oxadiazolyl/1,3,4-thiadiazolyl)methylthio)methylene)malononitriles.
AID607163	Antioxidant activity against DPPH free radical assessed as compound able to consume half the initial amount of DPPH free radical after 30 to 60 mins by spectrophotometry	2011	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14	Exploration of antimicrobial and antioxidant potential of newly synthesized 2,3-disubstituted quinazoline-4(3H)-ones.
AID1712224	Antioxidant activity in Sprague-Dawley rat Cerebral cortex neuron assessed as total antioxidant capacity by measuring trolox equivalents at 10 uM after 24 hrs	2016	Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14	New bifunctional antioxidant/σ1 agonist ligands: Preliminary chemico-physical and biological evaluation.
AID1549508	Haemolytic activity in human erythrocytes assessed as induction of hemolysis at 1.25 mM after 30 mins relative to H202	2019	European journal of medicinal chemistry, May-01, Volume: 169	Anticancer activity, dual prooxidant/antioxidant effect and apoptosis induction profile of new bichalcophene-5-carboxamidines.
AID1366171	Antioxidant activity assessed as DPPH free radical scavenging activity at 5 ug/ml after 30 mins by spectrophotometric analysis	2017	Bioorganic & medicinal chemistry, 11-01, Volume: 25, Issue:21	Design and synthesis of benzimidazole-based Rho kinase inhibitors for the treatment of glaucoma.
AID387800	Radical scavenging activity in human HL-60 cells assessed as reduction of hydrogen peroxide-induced ROS generation at 30 uM after 1 hr by 2',7'-dichlorofluorescein diacetate based flow cytometry	2008	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 18, Issue:19	2,2'-Pyridoin derivatives protect HL-60 cells against oxidative stress.
AID294919	Inhibition of nitric oxide radical scavenging activity	2007	European journal of medicinal chemistry, Aug, Volume: 42, Issue:8	Syntheses of new tetrasubstituted thiophenes as novel anti-inflammatory agents.
AID1466638	Antioxidant activity assessed as inhibition of DPPH free radical at 75 uM after 30 mins relative to control	2017	Bioorganic & medicinal chemistry, 07-01, Volume: 25, Issue:13	Antioxidant and anticholinesterase potential of diterpenoid alkaloids from Aconitum heterophyllum.
AID274759	Antioxidant activity assessed by DPPH radical scavenging assay	2007	Journal of natural products, Jan, Volume: 70, Issue:1	Bioactive bibenzyl derivatives and fluorenones from Dendrobium nobile.
AID486891	Antioxidant activity assessed as DPPH radical scavenging activity after 2 hrs	2010	Journal of natural products, Jun-25, Volume: 73, Issue:6	Dihydro-beta-agarofuran sesquiterpenes and pentacyclic triterpenoids from the root bark of Osyris lanceolata.
AID1555976	Inhibition of equine serum BuChE using S-butyrylthiocholine iodide as substrate preincubated with enzyme for 30 mins followed by substrate addition and measured after 30 mins by Ellman's method	2019	European journal of medicinal chemistry, Sep-01, Volume: 177	Design, synthesis, and biological evaluation of rutacecarpine derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease.
AID36972	Percent inhibition of Alpha-amylase activity was determined at 5 mM	2000	Bioorganic & medicinal chemistry letters, Jul-17, Volume: 10, Issue:14	Kinetic characterisation of ene-diol-based inhibitors of alpha-amylase.
AID1610135	Antiproliferative activity against human HCT116cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Dec-15, Volume: 184	Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives.
AID670406	Antioxidant activity assessed as superoxide radical scavenging activity	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4',7-dihydroxyflavone and their analogues.
AID1182518	Radioprotective activity against gamma-irradiated human MOLT4 cells preincubated for 1 hr at <50 uM before gamma-irradiation measured after 18 hrs by erythrosine B dye-exclusion test	2014	Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15	Design and synthesis of 8-hydroxyquinoline-based radioprotective agents.
AID502060	Antioxidant activity assessed as ABTS radical scavenging activity at 100 ug/ml	2010	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17	InCl3 mediated one-pot multicomponent synthesis, anti-microbial, antioxidant and anticancer evaluation of 3-pyranyl indole derivatives.
AID1434781	Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins	2017	Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4	Anti-HSV-1, antioxidant and antifouling phenolic compounds from the deep-sea-derived fungus Aspergillus versicolor SCSIO 41502.
AID1065896	Growth promoting activity in rat 3T3 cells assessed as change in cell growth under anoxic condition at 100 ug/ml measured over 4 days by WST-1 assay	2013	Journal of medicinal chemistry, Dec-27, Volume: 56, Issue:24	Controlled oxygen release from pyridone endoperoxides promotes cell survival under anoxic conditions.
AID549261	Antioxidant activity assessed as DPPH radical scavenging activity at 5 ug/ml after 30 mins	2010	Journal of natural products, Nov-29, Volume: 73, Issue:11	Inhibition of melanogenesis and oxidation by protocatechuic acid from Origanum vulgare (oregano).
AID351091	Antioxidant activity assessed as DPPH free radical scavenging activity by spectrophotometry	2009	Bioorganic & medicinal chemistry, May-01, Volume: 17, Issue:9	Preparation of two sets of 5,6,7-trioxygenated dihydroflavonol derivatives as free radical scavengers and neuronal cell protectors to oxidative damage.
AID693515	Antioxidant activity assessed as inhibition of H2O2 radical scavenging activity by spectrophotometric analysis	2012	European journal of medicinal chemistry, Dec, Volume: 58	Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d]pyrimidine derivatives.
AID1462747	Antioxidant activity assessed as DPPH free radical scavenging activity by measuring radical-scavenging activity factor (moles of radicals scavenged by each mol of antioxidant) at 20 uM measured at 30 mins by HPLC	2017	Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20	Structural evidence for the DPPH radical-scavenging mechanism of 2-O-α-d-glucopyranosyl-l-ascorbic acid.
AID1655201	Antioxidant activity assessed as ABTS radical scavenging activity incubated for 40 mins	2020	ACS medicinal chemistry letters, May-14, Volume: 11, Issue:5	Synthesis, Cytotoxicity Evaluation, and Computational Insights of Novel 1,4-Diazepane-Based Sigma Ligands.
AID652737	Antioxidant activity using deaerated ethanol as substrate assessed as hydroxy radical additive level at 1 mmol/L after gamma-irradiation	2012	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7	Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
AID1055053	Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins by spectrophotometry	2013	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23	Facile preparation of tetrahydro-5H-pyrido[1,2,3-de]-1,4-benzoxazines via reductive cyclization of 2-(8-quinolinyloxy)ethanones and their antioxidant activity.
AID1730964	Antioxidant activity assessed as nitric oxide radical scavenging activity at 100 ug/ml (Rvb = 25.8 to 41.6 %)	2021	Bioorganic & medicinal chemistry letters, 03-15, Volume: 36	Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme.
AID631128	Antioxidant activity assessed as trolox equivalent by TEAC assay	2011	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 21, Issue:22	Discovery and synthesis of novel substituted benzocoumarins as orally active lipid modulating agents.
AID652729	Antioxidant activity using ethanol as substrate assessed as acetaldehyde level at 1 mmol/L after gamma-irradiation by gas chromatography (Rvb = 7.06 +/- 0.28 10'7 mol/J)	2012	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7	Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
AID1466639	Antioxidant activity assessed as inhibition of DPPH free radical at 100 uM after 30 mins relative to control	2017	Bioorganic & medicinal chemistry, 07-01, Volume: 25, Issue:13	Antioxidant and anticholinesterase potential of diterpenoid alkaloids from Aconitum heterophyllum.
AID1810883	Antioxidant activity of compound assessed as trolox equivalent of AAPH radical scavenging activity preincubated for 15 mins followed by AAPH addition and measured every 2 mins for 90 mins by ORAC fluorescein assay
AID1194985	Antioxidant activity assessed as FRAP values at 50 ug/ml incubated at 37 degC for 5 mins by FeSO4.7H2O calibration curve based method	2015	Bioorganic & medicinal chemistry letters, , Volume: 25, Issue:10	Cytotoxic and antioxidant constituents from the leaves of Psidium guajava.
AID1487489	Antioxidant activity assessed as H2O2 free radical scavenging activity at 60 ug/ml after 10 to 15 mins by spectrophotometric analysis	2017	Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16	Synthesis, antioxidant, antifungal, molecular docking and ADMET studies of some thiazolyl hydrazones.
AID588213	Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents	2010	Chemical research in toxicology, Jan, Volume: 23, Issue:1	Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
AID437941	Antioxidant activity in Wistar rat brain assessed as inhibition of lipid peroxidation	2010	European journal of medicinal chemistry, Jan, Volume: 45, Issue:1	Synthesis, spectral characterization and biological evaluation of phosphorylated derivatives of galanthamine.
AID380424	Cytotoxicity against human HL60 cells by XTT assay	2006	Journal of natural products, Mar, Volume: 69, Issue:3	Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans.
AID1763932	Antioxidant activity assessed as DPPH free radical scavenging activity in iron free medium	2021	Bioorganic & medicinal chemistry letters, 07-01, Volume: 43	Green synthesis of therapeutically active 1,3,4-oxadiazoles as antioxidants, selective COX-2 inhibitors and their in silico studies.
AID693509	Antioxidant activity assessed as inhibition of nitric oxide free radical production at 100 ug/mL after 150 mins by Griess method relative to control	2012	European journal of medicinal chemistry, Dec, Volume: 58	Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d]pyrimidine derivatives.
AID977608	Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB	2009	The FEBS journal, Jun, Volume: 276, Issue:12	Polysaccharide binding sites in hyaluronate lyase--crystal structures of native phage-encoded hyaluronate lyase and its complexes with ascorbic acid and lactose.
AID1159550	Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening	2015	Nature cell biology, Nov, Volume: 17, Issue:11	6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
AID1159607	Screen for inhibitors of RMI FANCM (MM2) intereaction	2016	Journal of biomolecular screening, Jul, Volume: 21, Issue:6	A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	15548 (37.09)	18.7374
1990's	5608 (13.38)	18.2507
2000's	8696 (20.74)	29.6817
2010's	8915 (21.26)	24.3611
2020's	3157 (7.53)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	2,497 (5.52%)	5.53%
Reviews	2,694 (5.95%)	6.00%
Case Studies	804 (1.78%)	4.05%
Observational	50 (0.11%)	0.25%
Other	39,216 (86.64%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Clinical Trials (344)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
Comparative Evaluation of Vitamin C and Injectable-platelet Rich Fibrin in the Management of Thin Gingival Phenotype: A Split-mouth Randomized Clinical Trial.[NCT05841303]	Phase 4	13 participants (Anticipated)	Interventional	2023-07-01	Not yet recruiting
A Phase 1, Single-Dose Study to Evaluate the Pharmacokinetics of Intravenous Ascorbic Acid in Healthy Male and Female Volunteers[NCT02534753]	Phase 1	8 participants (Actual)	Interventional	2015-09-30	Completed
Local Vasoconstriction in Postural Tachycardia Syndrome[NCT01210430]	Early Phase 1	74 participants (Actual)	Interventional	2010-07-31	Completed
Phase II Double-blind Randomized Placebo-controlled 1-way Crossover Trial to Investigate Safety and Efficacy of the Ascorbic Acid and Tocopherol for the Treatment of the Fragile X Syndrome[NCT01329770]	Phase 2	30 participants (Actual)	Interventional	2010-12-31	Completed
The Effect of Antioxidant Vitamin Supplementation on Muscle Performance and Redox Status After Eccentric Training[NCT01290458]		28 participants (Actual)	Interventional	2009-06-30	Completed
The Effect of a Mixture of Micellized Curcumin/Boswellia Serrata/Ascorbic Acid on Health-related Quality of Life in Patients With Post-acute COVID-19 Syndrome.[NCT05150782]		32 participants (Anticipated)	Interventional	2022-01-17	Not yet recruiting
Clinical Outcomes of Intravenous Vitamin C Synergy With Tyrosine Kinase Inhibitor in Lung Adenocarcinoma Patients With Epidermal Growth Factor Receptor Mutations[NCT03799094]	Phase 1/Phase 2	150 participants (Anticipated)	Interventional	2018-12-05	Recruiting
Differences by Sex and Genotype in the Effects of Stress on Executive Functions[NCT04273880]	Phase 1	146 participants (Anticipated)	Interventional	2018-04-28	Recruiting
Comparison of Bioavailability of Liposomal and Traditional Formulation of Vitamin C[NCT05843617]		10 participants (Actual)	Interventional	2022-02-28	Completed
SIMCAP (Surgery in Metastatic Carcinoma of Prostate): Phase 2.5 Multi-Institution Randomized Prospective Clinical Trial Evaluating the Impact of Cytoreductive Radical Prostatectomy Combined With Best Systemic Therapy on Oncologic and Quality of Life Outco[NCT03456843]	Phase 2	190 participants (Anticipated)	Interventional	2018-03-14	Recruiting
Optimization of the Bowel Preparation Regimen for Colon Capsule Endoscopy Procedure[NCT05726097]	Phase 3	147 participants (Anticipated)	Interventional	2023-02-01	Recruiting
Influence Of Endothelial Function On Central and Peripheral Causes Of Exercise Impairment In Type 2 Diabetes[NCT00786019]		47 participants (Actual)	Interventional	2008-05-31	Completed
Tenofovir Disoproxil Fumarat 300 mg - Phyllanthus Urinaria 300mg - Adenosma Glutinosum 150mg - Eclipta Prostrata 150mg, Ascorbic Acid 500 mg Daily is Effective in the Long-term Treatment of Chronic and Acute Hepatitis B.[NCT01198860]		0 participants	Expanded Access		Approved for marketing
Administration of Intravenous Vitamin C in Novel Coronavirus Infection and Decreased Oxygenation (AVoCaDO): A Phase I/II Safety, Tolerability, and Efficacy Clinical Trial[NCT04357782]	Phase 1/Phase 2	20 participants (Actual)	Interventional	2020-04-16	Completed
The Effect of Vitamin C on Wound Healing In Mandibular Fracture Patients: A Double Blind, Placebo-controlled Randomized Clinical Trial[NCT03938584]		45 participants (Actual)	Interventional	2017-10-12	Completed
Vitamin C Supplementation Intervention for Patients With Heart Failure-A Pilot Study[NCT04036110]		36 participants (Actual)	Interventional	2018-08-14	Completed
Pilot Study for Determining the Impact of Ascorbic Acid Treatment on the Development and Treatment of Vasodilation in Cardiac Surgery[NCT03744702]	Early Phase 1	15 participants (Actual)	Interventional	2019-06-28	Completed
Intermittent Androgen Deprivation Therapy in the Era of AR Pathway Inhibitors; a Phase 3 Pragmatic Randomized Trial.[NCT05974774]	Phase 3	1,600 participants (Anticipated)	Interventional	2023-12-15	Not yet recruiting
Efficacy of Vitamin C, Vitamin E and Their Combination for Treatment of Restless Legs Syndrome in Hemodialysis Patients: a Randomized Double-blind, Placebo-controlled Trial[NCT01125033]	Phase 2/Phase 3	60 participants (Actual)	Interventional	2008-03-31	Completed
Evaluation of the Impact of Ascorbic Acid in the Prevention of Vancomycin Induced Nephrotoxicity[NCT03921099]	Phase 4	40 participants (Anticipated)	Interventional	2019-01-17	Recruiting
Prospective Placebo-Controlled Double-Blinded Trial for High-Dose Vitamin C Administration During the Acute Resuscitative Phase of Severe Thermal Injuries[NCT01587261]	Phase 2	0 participants (Actual)	Interventional	2017-06-30	Withdrawn(stopped due to This potential study was held up at the level of the FDA as they wouldn't approve and IND for the dose of vitamin C we wanted to use.)
A Randomized, Double-blind, Placebo-controlled Dose-ranging Study of OPK-88004 Once-a-day Dosing for 16 Weeks in Men With Signs and Symptoms of Benign Prostatic Hyperplasia[NCT03297398]	Phase 2	114 participants (Actual)	Interventional	2018-02-21	Terminated(stopped due to study terminated by sponsor decision)
Docetaxel Plus 6-month Androgen Suppression and Radiation Therapy Versus 6-month Androgen Suppression and Radiation Therapy for Patients With High Risk Localized or Locally Advanced Prostate Cancer: A Randomized Controlled Trial[NCT00116142]	Phase 3	350 participants (Actual)	Interventional	2005-06-30	Completed
The Effect of Vitamin c on Preventing Complex Regional Pain Syndrome (CRPS Type I) Following Ankle Fracture, Prospective Double Blind Study[NCT01338129]		100 participants (Anticipated)	Interventional	2011-04-30	Not yet recruiting
Ascorbic Acid Versus Diode Laser in the Treatment of Gingival Hyperpigmentation: Histological and Clinical Randomized Study[NCT03252418]	Phase 4	10 participants (Actual)	Interventional	2015-10-07	Completed
Pharmacokinetics of Two Different High-dose Regimens of Intravenous Vitamin C in Critically Ill Patients[NCT02455180]	Phase 4	20 participants (Actual)	Interventional	2015-03-31	Completed
Effects of Long-term Vitamin C+E and Statin Therapy on Vasospasm Improvement and Regression of Atheroma in Patients With Variant Angina[NCT03228238]	Phase 4	300 participants (Anticipated)	Interventional	2014-09-01	Recruiting
The Effect of Vitamin C on Quality of Life of Terminal Cancer Patients[NCT03224572]	Phase 1/Phase 2	40 participants (Anticipated)	Interventional	2018-01-31	Not yet recruiting
Comparison of Efficiency and Tolerance of Sodium Picosulphate/ Magnesium Citrate, Polyethylene Glycol/Ascorbate and Oral Sulfate Solution Before Colonoscopy[NCT03698474]	Phase 4	612 participants (Actual)	Interventional	2018-10-25	Completed
Balloon Angioplasty of Dialysis AV Fistulae: Effect of Local Delivery of Inhibitors of Lysyl Oxidase (LysoLox) on Serial Angioplasty and Time to Restenosis[NCT03106948]	Phase 2	30 participants (Anticipated)	Interventional	2017-02-01	Recruiting
Vitamins B1 and C to Improve Outcomes in Patients With Severe Sepsis[NCT03592277]	Phase 2	120 participants (Actual)	Interventional	2018-09-14	Completed
Evaluating Vitamin C in Septic Shock: A Randomized Double Blind Placebo Controlled Trial[NCT03338569]	Phase 2/Phase 3	125 participants (Actual)	Interventional	2017-12-20	Completed
Adjunctive Intravenous Ascorbic Acid for Advanced Non-Small Cell Lung Cancer: A Double Blind, Placebo Controlled, Phase II Randomized Controlled Trial[NCT05849129]	Phase 2	90 participants (Anticipated)	Interventional	2024-02-01	Not yet recruiting
The Impact of Intravenous Vitamin C Combined With Nerve Blocks on Postoperative Pain and Recovery After Total Knee Arthroplasty.[NCT05514197]		69 participants (Actual)	Interventional	2022-06-01	Completed
Translation of in Vitro and in Vivo Ascorbate Research Into a New Treatment Option for Pancreatic Cancer: Phase I/IIa Clinical Trial[NCT01364805]	Phase 1	14 participants (Actual)	Interventional	2011-04-30	Completed
Outcomes of Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in the Early Treatment of Sepsis.[NCT03422159]	Phase 2	140 participants (Actual)	Interventional	2018-02-05	Completed
Ascorbic Ccid, Hydrocortisone, and Thiamine in Sepsis and Septic Shock - A Randomized, Double-Blind, Placebo-Controlled Trial[NCT03389555]	Phase 2/Phase 3	205 participants (Actual)	Interventional	2018-02-09	Completed
Randomized, Phase II Trial of Intravenous Ascorbic Acid (Vitamin C) as an Adjunct to Pazopanib in the First-Line or Post-Immunotherapy Setting for Metastatic or Unresectable Clear Cell Renal Cell Carcinoma (ccRCC)[NCT03334409]	Phase 2	5 participants (Actual)	Interventional	2018-02-16	Terminated(stopped due to Due to loss of funding from the private foundation source)
The Effect Of Hyaluronic Acid And Melatonin With Systemic Administration of Vitamin C On Implant Stability After Immediate Implant Placement in Anterior and Premolar Region in Systemically Healthy Patients[NCT03804177]	Phase 4	24 participants (Anticipated)	Interventional	2019-02-10	Not yet recruiting
Vitamin C for the Prevention of UTI in Women Who Undergo Elective GYN Surgeries: a Study Protocol for a Randomized Controlled Trial[NCT03800667]	Early Phase 1	0 participants (Actual)	Interventional	2018-08-08	Withdrawn(stopped due to No funds)
The Role of a Single Oral Dose (2g) of Vitamin C in Reducing Intensity of Pain and Opioids Consumption in Patients Undergoing Laparoscopic Cholecystectomy. A Randomized, Double-blinded, Placebo-controlled Study[NCT01322061]	Phase 4	80 participants (Actual)	Interventional	2010-11-30	Completed
A Randomized Clinical Trial of Antioxidants to Prevent Preeclampsia and An Observational Cohort Study to Predict Preeclampsia[NCT00135707]	Phase 3	10,154 participants (Actual)	Interventional	2003-06-30	Completed
A 4-month, Randomized, Placebo-controlled, Double-blind Intervention of Antioxidant Supplementation in Overweight Children Enrolled in an Outpatient Weight-loss Program: Effects on Oxidative and Inflammatory Markers, Hepcidin, Iron Status, and Components [NCT01316081]		45 participants (Actual)	Interventional	2011-03-31	Completed
Effect of Oral Vitamin C on The Inflammatory Biomarkers in Hemodialysis[NCT01356433]	Phase 4	128 participants (Actual)	Interventional	2011-08-31	Completed
Phase IB/II Trial of High Dose Ascorbic Acid (AA) + Nanoparticle Paclitaxel Protein Bound + Cisplatin + Gemcitabine (AA NABPLAGEM) in Patients Who Have No Prior Therapy for Their Metastatic Pancreatic Cancer[NCT03697239]	Phase 1/Phase 2	0 participants (Actual)	Interventional	2019-06-30	Withdrawn(stopped due to FDA indicated the same study could not be conducted under multiple INDs)
Outcomes of Septic Shock Patients Treated With a Metabolic Resuscitation Bundle Consisting of Intravenous Hydrocortisone, Ascorbic Acid and Thiamine.[NCT03913468]		206 participants (Actual)	Observational	2019-01-01	Completed
Obesity, Inflammation and Oxidative Stress[NCT01028976]	Phase 3	512 participants (Actual)	Interventional	2010-01-31	Completed
The Effect of Prebiotics on Iron Absorption in Women With Low Iron Stores: Determination of a Dose-dependent Effect of Galacto-oligosaccharides on Iron Absorption, With and Without Addition of Ascorbic Acid[NCT03762148]		46 participants (Actual)	Interventional	2019-04-01	Completed
Combination Therapy of Vitamin C and Thiamine for Septic Shock: Multi-center, Double-blinded, Randomized, Controlled Study[NCT03756220]	Phase 2	116 participants (Actual)	Interventional	2018-12-01	Completed
Chronotherapeutic Use of Vitamin C to Reduce Morning Cardiovascular Risk[NCT03290612]		10 participants (Actual)	Interventional	2018-02-13	Completed
A Multi-center, Randomized, Placebo-controlled, Double-blind, Adaptive Clinical Trial of Vitamin C, Thiamine and Steroids as Combination Therapy in Patients With Sepsis.[NCT03509350]	Phase 3	501 participants (Actual)	Interventional	2018-08-22	Completed
The VitamIn C, HydrocorTisone and ThiAMINe in Patients With Septic Shock Trial (VITAMINS Trial) - A Prospective, Feasibility, Pilot, Multi-centre, Randomised, Open-label Controlled Trial[NCT03333278]	Phase 2	216 participants (Actual)	Interventional	2018-05-02	Completed
A Phase 1/2 Study of Ixazomib as a Replacement for Bortezomib or Carfilzomib for Multiple Myeloma (MM) Patients Recently Relapsed or Refractory to Their Last Combination Regimen Containing Either Bortezomib or Carfilzomib[NCT02206425]	Phase 1/Phase 2	45 participants (Actual)	Interventional	2014-09-30	Completed
Treatment of Non-Anemic Iron Deficiency in Pregnancy: a Double-Blind Randomized Control Trial[NCT05423249]		150 participants (Anticipated)	Interventional	2022-08-12	Recruiting
Efficacy of Hydroxychloroquine for Post-exposure Prophylaxis (PEP) to Prevent Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Among Adults Exposed to Coronavirus Disease (COVID-19): a Blinded, Randomized Study[NCT04328961]	Phase 2/Phase 3	943 participants (Actual)	Interventional	2020-03-31	Completed
Prospective Double Blind Study of the Effect of Intravenous High Dose Ascorbic Acid in Women Receiving Adjuvant or Neo-Adjuvant Chemotherapy for Early Stage Breast Cancer[NCT02521077]	Phase 2	0 participants (Actual)	Interventional	2017-05-31	Withdrawn(stopped due to Manufacturer unwilling to provide information needed for IND application.)
"Influence of High Vitamin C Dose on Lactate During Extracorporeal Circulation for Heart Surgery and During the 24 Hours Thereafter. (Double Blind Prospective Randomised Study)"[NCT04046861]		200 participants (Anticipated)	Interventional	2023-02-01	Not yet recruiting
Targeting TET2 Mutations in Myelodysplastic Syndromes and Acute Myeloid Leukemia (AML) With Azacitidine and Ascorbic Acid[NCT03397173]	Phase 2	12 participants (Actual)	Interventional	2018-03-16	Completed
Randomized Clinical Trial to Evaluate the Colon Cleansing Quality of Polyethylene Glycol Compared With Polyethylene Glycol Plus Ascorbic Acid in Patients With Past Poor Colonic Preparation[NCT02073552]	Phase 4	472 participants (Actual)	Interventional	2014-05-31	Completed
Comparative and Additive Effects of Fish Oil and Ascorbic Acid Supplementation on Exercise-Induced Bronchoconstriction and Airway Inflammation in Asthma[NCT01057615]	Phase 1	14 participants (Actual)	Interventional	2010-03-31	Completed
The Efficacy of Perioperative Parenteral Ascorbic Acid in Reducing Oxidative Stress Among Patients Undergoing Free Flap Reconstructive Surgery: A Prospective Multicenter Randomized Controlled Pilot Trial[NCT05327348]	Phase 3	34 participants (Anticipated)	Interventional	2022-09-25	Recruiting
Effect of Ascorbic Acid Administration on Restenosis of Dysfunctional Hemodialysis Vascular[NCT03524846]	Phase 2	93 participants (Actual)	Interventional	2011-04-30	Completed
Phase 1b/2 Neoadjuvant High Dose Ascorbate With Concurrent Preoperative Radiation in Patients With Locally Advanced Soft Tissue Sarcomas of Extremity, Trunk and Retroperitoneum[NCT03508726]	Phase 1/Phase 2	25 participants (Actual)	Interventional	2019-06-27	Active, not recruiting
Oxaloacetate Supplementation for Emotional PMS; Measuring Improvements in Depression, Anxiety, Perceived Stress, and Aggression[NCT03509714]		48 participants (Actual)	Interventional	2016-10-17	Completed
Effects of Ascorbic Acid Administration in the Treatment of Anemia in Chronic Hemodialysed Patients With Iron Overload[NCT02225886]	Phase 4	100 participants (Anticipated)	Interventional	2020-02-01	Recruiting
The Effect of Liposome Vitamin C on the Absorption[NCT04886752]		11 participants (Actual)	Interventional	2019-06-10	Completed
Metastasis-directed Radiotherapy (MDRT) for Men With De-novo Oligometastatic Prostate Cancer Treated With Long-term Androgen Deprivation Therapy in the STAMPEDE Trial (METANOVA)[NCT06150417]	Phase 2	200 participants (Anticipated)	Interventional	2024-04-01	Not yet recruiting
Vitamins C and Vitamin E and Hypertrophy Adaptations to Resistance Traini[NCT04828642]		30 participants (Actual)	Interventional	2021-02-01	Completed
Study of Safty and Efficacy of Adjuvant Vitamin c in Augmenting Iron Chelation[NCT02083575]	Phase 2/Phase 3	50 participants (Anticipated)	Interventional	2014-04-30	Not yet recruiting
Clinical Study of an Ascorbic Acid Derivative Dentifrice in Patients With Gingivitis[NCT02102295]	Phase 3	300 participants (Actual)	Interventional	2006-09-30	Completed
A Multicentre Concealed-Allocation Parallel-Group Blinded Randomized Controlled Trial to Ascertain the Effect of High-Dose Intravenous Vitamin C Compared to Placebo on Mortality or Persistent Organ Dysfunction at 28 Days in Septic Intensive Care Unit Pati[NCT04404387]	Phase 3	800 participants (Anticipated)	Interventional	2022-07-22	Recruiting
A Study Evaluating the Therapeutic Efficacy of Tamsulosin and Tadalafil Compared to Placebo in the Treatment and Prevention of Urinary Disorders After Transperineal Prostate Biopsy[NCT05537272]	Phase 4	120 participants (Anticipated)	Interventional	2022-09-01	Enrolling by invitation
Effect of Ascorbic Acid Administration on Intraoperative Blood Loss and Wound Healing in Total Abdominal Hysterectomy[NCT03965637]	Phase 3	80 participants (Actual)	Interventional	2019-08-23	Completed
Effect of Ascorbic Acid Oral Supplementation in Assessing the Severity of Oral Mucositis in Chemo-radiation Therapy of Head and Neck Cancers.[NCT02868151]	Phase 2/Phase 3	180 participants (Actual)	Interventional	2016-08-31	Completed
Effect of Vitamin C Infusion on Coronary Reperfusion Indexes[NCT01090895]	Phase 4	80 participants (Anticipated)	Interventional	2010-03-31	Recruiting
A Phase II Trial of Pharmacological Ascorbate, Gemcitabine, and Nab-Paclitaxel for Metastatic Pancreatic Cancer (PACMAN 2.1)[NCT02905578]	Phase 2	65 participants (Anticipated)	Interventional	2018-11-28	Active, not recruiting
Gemcitabine, Ascorbate, Radiation Therapy for Pancreatic Cancer, Phase I[NCT01852890]	Phase 1	16 participants (Actual)	Interventional	2014-01-31	Active, not recruiting
A Phase I Trial of High-Dose Ascorbate in Glioblastoma Multiforme[NCT01752491]	Phase 1	13 participants (Actual)	Interventional	2013-04-01	Active, not recruiting
Pre-Surgical Androgen Deprivation Therapy With or Without Axitinib in Previously Untreated Prostate Cancer Patients With Known or Suspected Lymph Node Metastasis[NCT01409200]	Phase 2	73 participants (Actual)	Interventional	2012-03-26	Active, not recruiting
Early High-dose Vitamin C in Post-cardiac Arrest Syndrome[NCT03509662]	Phase 2	270 participants (Anticipated)	Interventional	2019-10-07	Recruiting
Vitamin C 4 Care Homes: a Pilot and Feasibility Study to Assess Daily Vitamin C Requirement of Care Home Residents[NCT05122481]		20 participants (Anticipated)	Interventional	2023-01-15	Not yet recruiting
An Open-Label Pilot Study of the Safety, Tolerability and Anti-Viral Activity of High Dose Intravenous Ascorbic Acid in Patients Chronically Infected With Hepatitis C Virus Genotype 1, Who Have Failed Prior Therapy With Interferon-alpha and Ribavirin[NCT01250743]		10 participants (Anticipated)	Interventional	2009-01-31	Terminated
Initiation of Vitamin C, Thiamine and Hydrocortisone Therapy for Septic Shock in Adults: A Randomized Clinical Trial[NCT03872011]	Phase 3	408 participants (Actual)	Interventional	2019-02-19	Completed
Phase 2 Study of High Dose Ascorbic Acid in Solid Tumor Disease[NCT01125449]	Phase 2	30 participants (Anticipated)	Interventional	2011-01-31	Suspended(stopped due to Awaiting response from FDA as to status of parenteral ascorbic acid manufactured by Bioniche (Ireland).)
Phase IB/II Trial of High Dose Ascorbic Acid (AA) + Nanoparticle Paclitaxel Protein Bound + Cisplatin + Gemcitabine (AA NABPLAGEM) in Patients Who Have Had No Prior Therapy for Their Metastatic Pancreatic Cancer[NCT03797443]	Phase 1/Phase 2	0 participants (Actual)	Interventional	2019-01-01	Withdrawn(stopped due to Regulatory Review needed)
Evaluation of the Impact of Rutin and Vitamin C Combination on Oxidative Stress, Insulin Sensitivity and Lipid Profile in Type 2 Diabetic Patients[NCT03437902]	Phase 2/Phase 3	53 participants (Actual)	Interventional	2018-02-24	Completed
Effect of Perioperative Application of Ascorbic Acid on Postoperative Pulmonary Complications in Patients Undergoing Cardiac Surgery[NCT03756727]	Early Phase 1	110 participants (Anticipated)	Interventional	2018-12-01	Not yet recruiting
Lessening Organ Dysfunction With VITamin C (LOVIT)[NCT03680274]	Phase 3	872 participants (Actual)	Interventional	2018-11-08	Completed
Phase IB/II Trial of High Dose Ascorbic Acid (AA) + Nanoparticle Paclitaxel Protein Bound + Cisplatin + Gemcitabine (AA NABPLAGEM) in Patients Who Have No Prior Therapy for Their Metastatic Pancreatic Cancer[NCT03908333]	Phase 1/Phase 2	0 participants (Actual)	Interventional	2019-05-01	Withdrawn(stopped due to Request to close per funding sponsor. Site not moving forward with trial.)
A Head-to-head Comparison of Efficiency and Tolerance of 4-L Polyethylene Glycol and Sodium Picosulphate/ Magnesium Citrate, Polyethylene Glycol/Ascorbate Before Colonoscopy[NCT02956057]	Phase 4	1,044 participants (Actual)	Interventional	2016-11-12	Completed
Intensive High-volume Bowel Cleansing Regimen Versus Low-volume Bowel Regimen in Patients With a High Risk of Poor Colonic Cleansing Following a Validated Predictive Score[NCT03830489]	Phase 4	260 participants (Actual)	Interventional	2019-02-04	Completed
Randomised, Phase III Multicenter, Open Study of Lanreotide in Non Metastatic Castration-resistant Prostate Cancer Patients Presenting Elevated Chromogranin A Levels[NCT01313273]	Phase 3	3 participants (Actual)	Interventional	2011-06-30	Terminated(stopped due to Poor enrolment)
The Effect of Subconjunctival Vitamin c on Recovery Rate and End Result From Eye Burn.[NCT00734695]	Phase 1	20 participants (Anticipated)	Interventional	2009-07-31	Withdrawn(stopped due to couldn't recruit patients)
Randomized Phase III Trial Comparing Cabazitaxel Combination Hormone Therapy to Hormone Therapy Alone in Metastatic Prostate Cancer or High Risk Disease[NCT01978873]	Phase 3	400 participants (Anticipated)	Interventional	2012-11-30	Recruiting
A First-in-Human Clinical Trial of Pharmacologic Ascorbate and Ferumoxytol Combined With Concomitant Temozolomide and External Beam Radiation Therapy for Newly Diagnosed Glioblastoma[NCT04900792]	Phase 1	12 participants (Anticipated)	Interventional	2023-02-28	Active, not recruiting
Phase II, Double-blind, Randomized, 1-way Cross-over, to Investigate the Effectiveness of the Combination of Ascorbic Acid (Vitamin C) and Tocopherol (Vitamin E) Versus Placebo for the Treatment of Depressive Disorders in Elderly[NCT02793648]	Phase 2	50 participants (Actual)	Interventional	2014-10-31	Completed
Effect of Ascorbic Acid as a Final Flush on Post-operative Pain After Single Visit Root Canal Treatment for Patients With Symptomatic Irreversible Pulpits Related to Mandibular Molars: Randomized Controlled Trial.[NCT05478044]		30 participants (Anticipated)	Interventional	2022-08-31	Not yet recruiting
Sideral Forte in Prosthetic Hip and Knee Surgery[NCT04078880]		82 participants (Actual)	Interventional	2018-12-04	Completed
HIGH-dose Intravenous VItamin C in Patients With Septic Shock: HIGH-VIS Trial[NCT04796636]	Phase 1	30 participants (Anticipated)	Interventional	2021-09-27	Recruiting
A Phase I Double-Blind Randomized Placebo-Controlled Trial of Combination Therapy to Treat COVID-19 Infection[NCT04482686]	Phase 1	31 participants (Actual)	Interventional	2020-12-09	Active, not recruiting
Advanced ChemoHormonal Therapy for Treatment Naïve Metastatic Prostate Cancer: Apalutamide and Abiraterone Acetate With Prednisone and Androgen Deprivation Therapy After Treatment With Docetaxel and Androgen Deprivation Therapy[NCT04267887]	Phase 2	7 participants (Actual)	Interventional	2020-05-11	Active, not recruiting
High Dose Ascorbic Acid (HDAA) in Patients With Plasma Cell Disorders[NCT03602235]	Phase 1	9 participants (Anticipated)	Interventional	2019-03-05	Recruiting
Clinical Pilot Study on Antioxidant Uptake and Downstream Effects[NCT04463030]		24 participants (Anticipated)	Interventional	2020-07-01	Recruiting
Evaluation of the Effect of Local Injected Vitamin C on Accelerating the Orthodontic Movement of Maxillary Canine Impaction: A Clinical Trial[NCT03260829]		12 participants (Actual)	Interventional	2014-01-31	Completed
Use of ARINA-1 in an Intermediate Size Patient Population of Bilateral Lung Transplant Patients With CLAD Grade 0 at Duke University to Improve FEV1[NCT03226431]	Phase 1	6 participants (Actual)	Interventional	2017-12-11	Completed
Intravenous Iron Isomaltoside Versus Oral Iron Supplementation for Treatment of Iron Deficiency in Pregnancy: a Randomised, Comparative, Open-label Trial[NCT03188445]	Phase 4	201 participants (Actual)	Interventional	2017-07-11	Completed
Comparative Study on Effects of Sublingual Misoprostol in Addition to Standard Active Management of Third Stage of Labour in Low Risk Parturients in Lagos State University Teaching Hospital, Ikeja.[NCT02424201]	Early Phase 1	660 participants (Anticipated)	Interventional	2015-06-30	Not yet recruiting
Phase II Study of PARP Inhibitor Olaparib and IV Ascorbate in Castration Resistant Prostate Cancer[NCT05501548]	Phase 2	15 participants (Anticipated)	Interventional	2023-06-30	Recruiting
Phase I/II Randomized Study to Evaluate the Role of Intravenous Ascorbic Acid Supplementation to Conventional Neoadjuvant Chemotherapy in Women With Breast Cancer[NCT03175341]	Phase 1/Phase 2	30 participants (Anticipated)	Interventional	2018-10-01	Not yet recruiting
Effectiveness of Doses of Vitamin c and Zinc in Patients With High Enterocutaneous Fistulas Receiving Nutrition Parenteral Therapy on Closure and Recurrence. Randomized Clinical Trial.[NCT06009744]		76 participants (Anticipated)	Interventional	2023-08-31	Recruiting
Evaluation of the Effect of Citicoline (Cebrolux 800 mg) and Docosahexaenoic Acid (DHA) Compound (BrudyPio 1.5 g) on the Visual Function of Patients With Glaucoma With a Pilot Study[NCT05527106]		73 participants (Actual)	Interventional	2015-03-12	Completed
The Effect of Acetylcysteine and Ascorbic Acid on the Prevention of Radiographic-contrast-agent Induced Reduction in Renal Function in ICU Patients.[NCT01017796]	Early Phase 1	100 participants (Anticipated)	Interventional	2009-01-31	Active, not recruiting
Effect of Colon Delivered Vitamin C on Gut Microbiota and Related Health Biomarkers in Healthy Older Adults[NCT05598619]		264 participants (Anticipated)	Interventional	2022-07-01	Recruiting
Hmong Microbiome ANd Gout, Obesity, Vitamin C (HMANGO-C)[NCT04938024]		135 participants (Actual)	Interventional	2021-03-28	Completed
A Phase 2 Randomized Open-label 2-Treatment 2-Sequence 2-Period Crossover PK Study to Compare Plasma Concentrations of BH4 in Subjects With Endothelial Dysfunction Following 14 Days of Treatment by 2 Regimens: 6R-BH4 With Vitamin C and 6R-BH4 Alone[NCT00532844]	Phase 2	52 participants (Actual)	Interventional	2007-09-30	Completed
Phase I/II Study of the Combination of Bortezomib With Arsenic Trioxide, Ascorbic Acid and High-Dose Melphalan for Patients With Multiple Myeloma[NCT00469209]	Phase 1/Phase 2	60 participants (Actual)	Interventional	2006-06-30	Completed
Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia[NCT02735707]	Phase 3	10,000 participants (Anticipated)	Interventional	2016-04-11	Recruiting
Microneedling With Vitamin C Versus Injectable Vitamin C for Depigmentation in Physiological Gingival Melanin Hyperpigmentation: A Randomized Controlled Clinical Trial[NCT05786885]		22 participants (Anticipated)	Interventional	2023-04-30	Not yet recruiting
Randomized Controlled Trial on the Effect of Vitamin C Supplementation in Autologous Stem Cell Transplantations[NCT03964688]	Phase 2	47 participants (Actual)	Interventional	2019-12-10	Completed
Randomized, Double -Blind, Placebo Controlled, Trial to Evaluate the Effect of Zinc and Ascorbic Acid Supplementation in COVID-19 Positive Hospitalized Patients in BSMMU[NCT04558424]		50 participants (Anticipated)	Interventional	2020-10-01	Not yet recruiting
[NCT00000555]	Phase 3	0 participants	Interventional	1996-08-31	Completed
Efficacy of High Dose Vitamin C Parenteral Supplement on Amelioration of Fatigue in Company Workers After Work: A Double-Blind, Randomized Controlled Trial[NCT00633581]	Phase 2/Phase 3	150 participants (Actual)	Interventional	2008-03-31	Completed
A Randomized, Double-Blind, Placebo-Controlled Dose Escalation, Inpatient Phase I Study to Determine the Safety and Immunogenicity of a Single Oral Dose of a Combined Live, Attenuated, Enterotoxigenic Escherichia Coli (ETEC)-Cholera Vaccine (Peru-15 pCTB)[NCT00654108]	Phase 1	62 participants (Actual)	Interventional	2008-06-02	Completed
The Effect of Hydrocortisone-Ascorbic Acid and Thiamine Therapy on the Outcome of Patients With Sepsis: A Prospective Randomized Double-Blinded Controlled Trial[NCT04160676]		80 participants (Actual)	Interventional	2019-12-01	Completed
A Pilot Phase II Study of Decitabine, Arsenic Trioxide and Ascorbic Acid for Patients With Myelodysplastic Syndrome[NCT00621023]	Phase 2	7 participants (Actual)	Interventional	2007-11-30	Completed
Vitamin C Infusion for TReatment in Sepsis and Alcoholic Hepatitis[NCT03829683]	Phase 2	20 participants (Actual)	Interventional	2019-04-16	Completed
A Phase I Study of Bevacizumab and Intravenous Ascorbic Acid for Patients With Recurrent High Grade Glioma[NCT02833701]	Phase 1	9 participants (Actual)	Interventional	2016-03-31	Terminated
Vitamin C for the Prevention of Catheter-associated Urinary Tract Infections in Women Who Undergo Elective Gynecological Surgeries: a Study Protocol for a Randomized Double Blinded Controlled Trial.[NCT04261036]	Early Phase 1	0 participants (Actual)	Interventional	2019-07-20	Withdrawn(stopped due to Unfortunately, the economic crisis in Lebanon precluded utilization of available funding to recruit patients at the specified institution. No patients were recruited.)
A Phase II Study of High Dose Vitamin C Intravenous Infusion in Patients With Resectable or Metastatic Solid Tumor Malignancies[NCT03146962]	Phase 2	61 participants (Actual)	Interventional	2017-03-29	Completed
Pharmacokinetic Evaluation of Intravenous Ascorbic Acid[NCT01833351]	Phase 1	34 participants (Actual)	Interventional	2011-05-31	Completed
A Phase II Trial of Hypofractionated Radiation Therapy for Prostate Cancer With High Risk Features After Radical Prostatectomy[NCT03570827]	Phase 2	52 participants (Actual)	Interventional	2018-05-08	Active, not recruiting
Phase I - II Clinical Trial of Combination Conventional Cytotoxic Chemotherapy and Intravenous Vitamin C in Patients With Advanced Cancer or Hematologic Malignancy for Whom Cytotoxic Chemotherapy Alone is Only Marginally Effective[NCT01050621]	Phase 1/Phase 2	14 participants (Actual)	Interventional	2010-01-31	Completed
Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance[NCT04715022]	Phase 1/Phase 2	23 participants (Anticipated)	Interventional	2021-06-17	Recruiting
'A Prospective Randomized Trial to Assess the Impact of Ascorbic Acid on Outcomes and Complications Post Cardiac Surgeries''[NCT03639519]	Phase 4	100 participants (Anticipated)	Interventional	2018-04-15	Recruiting
Comparison Of The Effects Of Preoperative Melatonin Or Vitamin C Administration On Postoperative Analgesia[NCT02639741]	Phase 4	55 participants (Actual)	Interventional	2014-11-30	Completed
A Double-blind, Randomized, Controlled Study to Compare the Effects of Syrup With EpiCor and Vitamin C to Syrup With Vitamin C Alone on the Common Cold or Influenza in Generally Healthy Children[NCT04093206]		221 participants (Actual)	Interventional	2017-12-22	Completed
VItamin C in Thermal injuRY: The VICToRY Trial A Phase III Multi-center Randomized Trial[NCT04138394]	Phase 3	666 participants (Anticipated)	Interventional	2020-07-24	Recruiting
Intravenous Vitamin C for the Prevention of Postreperfusion Syndrome in Orthotopic Liver Transplantation From Deceased Donors[NCT05754242]	Phase 2	70 participants (Anticipated)	Interventional	2020-11-17	Recruiting
Effect of Ferrous Ascorbate Versus Liposomal Iron on Hemoglobin Concentration and Iron Indices in 6 to 59 Months Age Children With Nutritional Iron-Deficiency Anemia: A Double-blinded Single Centre Randomized Clinical Trial[NCT05957328]	Phase 3	96 participants (Anticipated)	Interventional	2023-08-31	Not yet recruiting
Evaluating Low-cost Automatic Water Disinfection Systems to Improve Water Quality and Child Health in Urban Bangladesh[NCT02606981]		1,549 participants (Actual)	Interventional	2015-07-31	Completed
Phase II Multicenter Study of Association of Arsenic Trioxide (ATO) and Ascorbic Acid in Myelodysplastic Syndromes[NCT00803530]	Phase 2	55 participants (Anticipated)	Interventional	2005-09-30	Terminated(stopped due to difficulties of enrollement)
The Safety and Efficacy of a Compound Natural Health Product in Children With Attention Deficit/Hyperactivity Disorder: A Pilot Study[NCT00704990]	Phase 2/Phase 3	28 participants (Actual)	Interventional	2008-09-30	Completed
Clinical Trial to Assess the Impact of a Nutritional Supplement on the Recovery of the Nutritional Status of Elderly Patients With Spontaneous Hip Fracture[NCT04183075]		82 participants (Anticipated)	Interventional	2020-09-30	Not yet recruiting
Phase I-II Study of Vitamin C Infusion in Combination With Local mEHT on Non Small Cell Lung Cancer Patients[NCT02655913]	Phase 1/Phase 2	97 participants (Actual)	Interventional	2015-12-31	Completed
In-Utero Smoke, Vitamin C, and Newborn Lung Function[NCT00632476]		282 participants (Actual)	Interventional	2007-03-31	Completed
THE EFFECT OF VITAMIN C ON POST-ORTHODONTIC TREATMENT RELAPSE: A RANDOMIZED CONTROLLED CLINICAL TRIAL[NCT06146296]	Phase 2/Phase 3	36 participants (Anticipated)	Interventional	2023-11-01	Recruiting
Barrow 5-ALA Intraoperative Confocal Evaluation Trial[NCT01502280]	Phase 3	127 participants (Actual)	Interventional	2010-11-30	Completed
Ascorbic Acid Treatment for Patients With Combined Mineralocorticoid and Glucocorticoid Deficiency Secondary to Nicotinamide Nucleotide Transhydrogenase Mutation[NCT02838472]		3 participants (Anticipated)	Interventional	2016-06-30	Enrolling by invitation
Effect of Vitamin C Supplementation in Patients With Primary Hypothyroidism Requiring High Levothyroxine Dosage; a Randomized Control Trial[NCT05733078]	Phase 2	40 participants (Anticipated)	Interventional	2023-04-30	Not yet recruiting
Interventional Testing of Gene-environment Interactions Via the Verifomics Mobile Application[NCT02758990]		16 participants (Actual)	Interventional	2016-03-31	Terminated(stopped due to Recruiting and financial constraints)
"Effect of Ascorbic Acid and Grape Seed Extract Vitis Vinifera L. in Oxidative Stress Induced by on Pump Coronary Artery by Pass Grafting Surgery"[NCT00839085]		72 participants (Actual)	Interventional	2008-11-30	Active, not recruiting
Effect of Age and Fitness on Vascular Function and Oxidative Stress During Acute Inflammation[NCT03889158]	Phase 4	35 participants (Actual)	Interventional	2019-03-25	Terminated(stopped due to COVID-19)
Effects of Vitamin C, Thiamine and Hydrocortisone in Septic Shock: a Randomized, Controlled Trial[NCT04039815]	Phase 4	80 participants (Anticipated)	Interventional	2019-12-03	Enrolling by invitation
A Double Blind, Randomized, Crossover Study to Compare the Effectiveness of Montelukast on Atopic Dermatitis in Koreans[NCT00903357]		54 participants (Actual)	Interventional	2009-08-31	Completed
Effect of Low Doses of Vitamin C on Salivary Cortisol , Heart Rate , Blood Pressure During Group Presentation[NCT04135378]	Phase 4	90 participants (Actual)	Interventional	2018-11-01	Completed
ACADEMIC: A Randomized Phase II Clinical Trial of ADT Combined With Abiraterone or Docetaxel in Metastatic Hormone Sensitive Prostate Cancer[NCT03827473]	Phase 2	1 participants (Actual)	Interventional	2019-02-08	Terminated(stopped due to The trial was closed because the changing standard of care landscape, making this trial not impactful anymore.)
Assessment of the Effect of Vitamin C on Anemia in Patients With Continuous Ambulatory Peritoneal Dialysi[NCT02780505]	Phase 4	66 participants (Actual)	Interventional	2011-11-30	Completed
Lead Detoxifying Effects of Ascorbic Acid Among School Going Adolescents of Karachi- A Cluster Randomized Control Trial[NCT02745873]	Phase 2/Phase 3	144 participants (Actual)	Interventional	2012-05-31	Completed
Parenteral Ascorbic Acid Repletion in TransplantatIon (PARTI): A Randomized, Double-Blinded, Placebo-Controlled Trial[NCT04756063]	Phase 4	90 participants (Anticipated)	Interventional	2024-01-31	Not yet recruiting
Phase I/II Trial of Arsenic Trioxide (As2O3) With Ascorbic Acid in the Treatment of Relapsed/Refractory Multiple Myeloma[NCT00006021]	Phase 1/Phase 2	22 participants (Actual)	Interventional	2000-06-30	Completed
A Randomized, Double-blind, Placebo-controlled, Multicenter Clinical Trial of Tanreqing Capsule Efficacy and Safety in the Treatment of COVID-19 (Mild and Common Type)[NCT05305456]	Phase 3	480 participants (Actual)	Interventional	2022-03-28	Completed
The Impact of Ascorbic Acid Therapy on Inflammatory Mediators in Cardiothoracic Surgery Patients: The Atrial Fibrillation Suppression Trial IV (AFIST IV) Pilot Study[NCT00519337]	Phase 4	25 participants (Actual)	Interventional	2008-10-31	Completed
The Effectiveness of High-dose Intravenous Vitamin c With Very Low Carbohydrate Diet for Terminal Colon Cancer Patients[NCT04035096]	Phase 1/Phase 2	40 participants (Anticipated)	Interventional	2020-01-01	Not yet recruiting
Evaluation of the Efficacy of Different Strategies to Treat Anemia in Mexican Children: A Randomized Clinical Trial[NCT00822380]		680 participants (Actual)	Interventional	2003-03-31	Completed
A Phase I Trial of Ascorbic Acid and Gemcitabine for the Treatment of Metastatic Pancreatic Cancer[NCT01049880]	Phase 1	15 participants (Actual)	Interventional	2009-12-31	Completed
Phase II Trial of Arsenic Trioxide With Ascorbic Acid in the Treatment of Adult Non-APL Acute Myelogenous Leukemia[NCT00184054]	Phase 2	11 participants (Actual)	Interventional	2002-04-30	Terminated(stopped due to Competing studies)
Evaluation of Cytotoxicity and Genetic Changes of High Dose Vitamin C Infusions in Castration Resistant Metastatic Human Prostate Cancer[NCT01080352]	Phase 2	31 participants (Actual)	Interventional	2010-11-30	Completed
A Randomized, Double-blind, Crossover Study Comparing the Tolerance of Two Forms of Vitamin C in Acid Sensitive Adults[NCT01873820]		50 participants (Actual)	Interventional	2008-03-31	Completed
Evaluation of the Effect of Body Weight and Composition on Iron Absorption and Blood Volume[NCT01884506]		64 participants (Actual)	Interventional	2013-06-30	Completed
Ph 2 Trial of G-FLIP (Low Doses Gemcitabine, 5FU, Leucovorin, Irinotecan & Oxaliplatin), Followed by G-FLIP-DM (G-FLIP + Low Doses Docetaxel & MitomycinC), When Used in Combination With Vitamin C, in Patients With Advanced Pancreatic Cancer[NCT01905150]	Phase 2	34 participants (Actual)	Interventional	2014-07-31	Completed
Mechanisms of Impaired Brain Blood Flow With Aging[NCT03775382]		34 participants (Actual)	Interventional	2017-10-30	Completed
A Phase II Study of Arsenic Trioxide in Combination With Thalidomide, Dexamethasone, and Ascorbic Acid[NCT00227682]	Phase 2	2 participants (Actual)	Interventional	2004-06-30	Terminated(stopped due to Terminated early due to funding suspension by grant sponsor.)
Percutaneous Pin Removal in the Outpatient Clinic - do Children Require Analgesia? A Randomized Controlled Trial[NCT01944085]		240 participants (Actual)	Interventional	2008-10-31	Completed
Effects of Nutritional Iron Absorption Enhancers and Inhibitors and Daytime on Absorption From Oral Iron Supplements[NCT05414474]		35 participants (Anticipated)	Interventional	2022-06-30	Not yet recruiting
a New Spark in Treating Oligorecurrent Prostate Cancer: Adding Systemic Treatment to Stereotactic Body Radiotherapy or Metastasectomy: Key to Long-lasting Event-free Survival?[NCT05352178]	Phase 3	873 participants (Anticipated)	Interventional	2022-04-20	Recruiting
Measuring Dietary Iron Absorption From Edible Insects and Assessing the Effect of Chitin Content on Iron Bioavailability: Stable Iron Isotope Studies in Young Women (Study 2, Xylotrupes Gideon)[NCT05328141]		11 participants (Anticipated)	Interventional	2022-05-20	Enrolling by invitation
Efficacy and Safety of Ivermectin for Treatment and Prophylaxis of COVID-19 Pandemic[NCT04668469]		600 participants (Actual)	Interventional	2020-06-08	Completed
A Randomised, Multi-Centre, Single-Blinded, Pivotal Phase III Trial to Assess the Efficacy, Acceptability and Safety of a New 2 Litre Gut Cleansing Solution NRL994 Versus a Standard Colon Preparation With 4L PEG+E.[NCT00389233]	Phase 3	360 participants (Actual)	Interventional	2002-06-30	Completed
Ascorbic Acid Combined With Ibuprofen in Hypoxic Ischemic Encephalopathy: A Randomized Controlled Trial.[NCT00624871]		60 participants (Actual)	Interventional	2004-04-30	Completed
Phase I/II Study of Arsenic Trioxide (Trisenox), Ascorbic Acid and Bortezomib Combination Therapy in Patients With Relapsed/Refractory Multiple Myeloma[NCT00590603]	Phase 1	25 participants (Actual)	Interventional	2008-07-31	Terminated(stopped due to Poor accrual - terminated during Phase I; Phase II never started.)
Reducing Frailty for Older Cancer Survivors Using Supplements (ReFOCUS): A Phase 2 Randomized Controlled Trial of Epigallocatechin-3-Gallate (EGCG) on Frailty and Inflammation in Older Survivors of Cancer[NCT04553666]	Phase 2	14 participants (Actual)	Interventional	2021-03-15	Completed
Evaluation of Combination Zinc and Green Tea Extract Supplementation on Reduction in Symptom Duration and Severity Associated With Community Respiratory Viral Infections: a Randomized Control Trial (ZiPhenol Study)[NCT04898023]	Phase 2	16 participants (Actual)	Interventional	2022-09-21	Terminated(stopped due to Loss of funding)
A Randomized Controlled Trial Comparing the Efficacy and Acceptability of Sodium Picosulphate/Magnesium Citrate With Low-volume PEG -Ascorbic Acid as Preparation for Colonoscopy.[NCT01603654]	Phase 4	300 participants (Actual)	Interventional	2011-01-31	Completed
A Multicentre, Randomized, Laboratory-blinded, Parallel-group Study to Demonstrate the Efficacy and Tolerability of Ferrous Bisglycinate Chelate in Iron Deficiency Anaemia and to Compare These With Those of Ferrous Ascorbate.[NCT01160198]	Phase 3	271 participants (Actual)	Interventional	2010-10-13	Completed
Lifestyle Intervention and Antioxidants in Children With Nonalcoholic Fatty Liver Disease: A Randomized, Controlled Trial[NCT00655018]	Phase 2/Phase 3	90 participants (Actual)	Interventional	2003-01-31	Completed
Effects of Supplemental Immunonutrition on Healing of Chronic Non-Healing Lower Extremity Ulcers in Diabetic Patients: A Pilot Study[NCT05281562]	Phase 2/Phase 3	1 participants (Actual)	Interventional	2022-07-01	Terminated(stopped due to There are not enough patients at our institution meeting eligibility criteria to complete the study as intended.)
"Open-label, Randomized Comparator Study for Evaluation the Bioavailability of Novo C Plus Vitamin C Containing Dietary Supplement in Healthy Subjects"[NCT02606773]	Phase 1	32 participants (Actual)	Interventional	2015-06-30	Completed
Efficacy and Safety of High-dose Vitamin C Combined With Traditional Chinese Medicine in the Treatment of Moderate and Severe Coronavirus Pneumonia (COVID-19)[NCT04664010]		30 participants (Actual)	Interventional	2020-02-06	Completed
Manipulation of L-Ascorbic Acid Level For The Treatment of Selected Cases Of Acute Myeloid Leukemia and Myelodysplastic Syndromes[NCT00329498]	Phase 2	25 participants	Interventional	1998-05-31	Suspended
[NCT01426490]	Phase 2/Phase 3	300 participants (Anticipated)	Interventional	2011-08-31	Recruiting
Phase II Study of Melphalan, Arsenic Trioxide, and Ascorbic Acid in Patients With Relapsed or Refractory Multiple Myeloma[NCT00085345]	Phase 2	0 participants (Actual)	Interventional		Withdrawn
Randomized, Double Blind, Placebo Controlled Exploratory Study To Assess the Efficacy and Safety of a Triple Combination of Ibuprofen+Mg+Ascorbic Acid for Acute Pain Treatment in Temporomandibular Join Disorder (TMJD) Patients[NCT02602483]	Phase 1/Phase 2	96 participants (Actual)	Interventional	2015-12-31	Completed
Chronic Study of the Effect of Grape Seed Extract Plus Ascorbic Acid on Endothelial Function in Patients With Coronary Artery Disease[NCT00554242]		40 participants (Anticipated)	Interventional	2007-07-31	Completed
A Randomized, Double-blind, Placebo-controlled Crossover Study Comparing the Bioavailability of Two Forms of Vitamin C in Plasma and Leukocytes Over 24 Hours.[NCT01852903]		40 participants (Actual)	Interventional	2011-05-31	Completed
2L Oral Bi-PegLyte Versus 2L Oral MoviPrep Regimen for Outpatient Colonic Preparation: A Randomized, Non-Inferiority Open Trial[NCT01865916]	Phase 4	309 participants (Actual)	Interventional	2013-04-30	Completed
Phase Ⅲ Study of IV Ascorbic Acid in Combination With XELOX vs Treatment With XELOX Alone as First-line Therapy for Advanced Gastric Cancer[NCT03015675]	Phase 3	200 participants (Anticipated)	Interventional	2017-03-12	Recruiting
Pilot Study of the Safety and Efficacy of Intravenous Vitamin C in Patients Undergoing Atrial Fibrillation Ablation[NCT03148236]	Phase 2	20 participants (Actual)	Interventional	2017-09-18	Completed
Prevention of Complex Regional Pain Syndrome Using Liposomal Encapsulated Vitamin C in Programmed Knee Surgery; A Prospective Randomized Trial[NCT04204200]		66 participants (Actual)	Interventional	2014-01-06	Completed
Efficacy of Vitamin C Administration for the Prevention of Postpolypectomy Bleeding[NCT03400020]		156 participants (Actual)	Interventional	2018-01-28	Completed
The Relationship of Hemoglobin A1c and Diabetic Wound Healing[NCT01350102]	Phase 4	2 participants (Actual)	Interventional	2012-02-29	Terminated(stopped due to study closed due to recruitment problems)
Mechanisms for Vascular Dysfunction and Exercise Tolerance in CF[NCT02690064]		13 participants (Actual)	Interventional	2015-04-30	Active, not recruiting
A Phase I Study of Oral Arsenic Trioxide With or Without Ascorbic Acid in Adults With Myelofibrosis[NCT01014546]	Phase 1	5 participants (Actual)	Interventional	2010-04-30	Terminated(stopped due to low accrual)
Determining the Safe Dosage of Ascorbic Acid Used in the Treatment of Occluded Totally Implanted Central Venous Catheter.[NCT01270152]	Phase 2	21 participants (Actual)	Interventional	2008-10-31	Completed
A Prospective Randomised Single-Blinded Multicentric and Pivotal Phase III Study Comparing the Efficacy, Safety and Acceptability of a New 2 Litres Gut Lavage Solution NRL994 Versus a Sodium Phosphate Solution for Colonoscopy Preparation[NCT00322062]	Phase 3	340 participants (Actual)	Interventional	2002-04-30	Completed
Antioxidant Effects on the Outcome of Ovarian Cancer[NCT00228319]	Phase 1/Phase 2	27 participants (Actual)	Interventional	2002-10-31	Completed
Pilot Study to Assess Effect of High Dose Ascorbic Acid (Vitamin C) on Inflammation Reduction in Cardiac Surgery Patients.[NCT02762331]	Phase 1	6 participants (Actual)	Interventional	2017-01-01	Terminated(stopped due to Therapy shown effective by larger studies)
The SU.VI.MAX Study. A Randomized, Placebo-controlled Prevention Trial of the Health Effects of Antioxidant Vitamins and Minerals.[NCT00272428]	Phase 3	13,000 participants	Interventional	1994-10-31	Completed
A Randomised, Single-Centre, Parallel-Group, Pilot Study to Assess the Efficacy, Safety and Patient Acceptability of a New 2-Litre Bowel Preparation Agent (MOVIPREP®) Compared With a Standard Bowel Preparation Agent (PICOLAX®)[NCT00312481]	Phase 2	65 participants (Actual)	Interventional	2005-07-31	Completed
Steroid, Thiamine and Ascorbic Acid During Post-Resuscitation Period for Comatose Out-of-hospital Cardiac Arrest Survivors (STAR) Trial: Multi-center, Randomized, Single-blinded, Controlled Pilot Study[NCT04921189]	Phase 2	160 participants (Anticipated)	Interventional	2021-12-31	Recruiting
Role of Ascorbic Acid Infusion in Critically Ill Patients With Transfusion Related Acute Lung Injury[NCT04153487]	Phase 2	40 participants (Actual)	Interventional	2019-11-30	Completed
The Effect of High Dose Versus Low Dose Intravenous Vitamin C (Ascorbic Acid)on Burn Injury Resuscitation[NCT00350077]		0 participants (Actual)	Interventional	2006-07-31	Withdrawn(stopped due to Inadequate resources to submit for approval)
Topical Tranexamic Acid Versus Topical Vitamin C With Microneedling in Periorbital Hyperpigmentation; Comparative Study[NCT04697992]		60 participants (Actual)	Interventional	2019-11-01	Completed
"A Randomized, Placebo-controlled, Double Masked 120 Subject Futility Design Clinical Trial of Ascorbic Acid Treatment of Charcot Marie Tooth Disease Type 1A."[NCT00484510]	Phase 2/Phase 3	110 participants (Actual)	Interventional	2007-04-30	Completed
Combining Active and Passive DNA Hypomethylation: A Randomized, Placebo-Controlled Phase II Study of the Efficacy and Safety of Oral Vitamin C in Combination With Azacitidine in Patients With Higher-Risk MDS, CMML-2 or Low-Blast Count AML[NCT03999723]	Phase 2	196 participants (Anticipated)	Interventional	2019-09-11	Recruiting
Epigenetics, Vitamin C, and Abnormal Hematopoiesis - Role of Vitamin C in Epigenetic Regulation in Hematopoiesis Sub-Study on CCUS, Low-Risk MDS, and CMML-0/1[NCT03682029]		109 participants (Actual)	Interventional	2017-11-21	Active, not recruiting
Vitamin C Intravenously With Chemotherapy in Peritoneal Metastatic Colorectal Cancer With High Expresison Level of GLUT3[NCT04516681]	Phase 3	400 participants (Anticipated)	Interventional	2020-09-01	Recruiting
Coronavirus Disease 2019- Using Ascorbic Acid and Zinc Supplementation (COVIDAtoZ) Research Study A Randomized, Open Label Single Center Study[NCT04342728]		214 participants (Actual)	Interventional	2020-04-08	Completed
Quantitative in Vivo Biomarkers of Oxidative Stress in Diabetes[NCT00845130]		42 participants (Actual)	Interventional	2009-09-30	Completed
A Phase 2 Trial of Pharmacological Ascorbate With Concurrent Chemotherapy and Radiation Therapy for Non-small Cell Lung Cancer[NCT02905591]	Phase 2	46 participants (Anticipated)	Interventional	2018-11-16	Recruiting
Vitamins C and E Combined With Cryotherapy on the Pain, Oxidative Stress and Inflammatory Response After Resistance Exercise Session in Untrained Volunteers[NCT02902315]		26 participants (Actual)	Interventional	2017-01-04	Completed
Effect of Ascorbic Acid on the Incidence of Post-operative Atrial Fibrillation in Patients Undergoing Cardiac Surgery[NCT01580683]	Phase 3	0 participants (Actual)	Interventional	2012-07-31	Withdrawn(stopped due to No funding obtained to support patient recruitment)
A Phase I Study of High-Dose IV Vitamin C Treatment in Patients With Solid Tumors[NCT00441207]	Phase 1	18 participants (Actual)	Interventional	2006-08-31	Completed
The Effect of Vitamin C on Growth Hormone Secretion[NCT01537094]	Phase 2	0 participants (Actual)	Interventional	2013-12-31	Withdrawn(stopped due to Unable to obtain funding to initiate the study. No subjects were enrolled.)
Phase II Study of Arsenic Trioxide, Ascorbic Acid, Dexamethasone, and Thalidomide in Patients With Previously Untreated High-Risk or Relapsed or Refractory Multiple Myeloma[NCT00112879]	Phase 2	0 participants (Actual)	Interventional		Withdrawn
A Pilot Study of the Efficacy of a Combination of Antioxidants and B Vitamins in Preventing the Recurrence of Hyperlactatemia in Subjects Who Have Limited Antiretroviral Options[NCT00037063]		0 participants (Actual)	Interventional		Withdrawn
Lessening Organ Dysfunction With VITamin C - COVID[NCT04401150]	Phase 3	392 participants (Actual)	Interventional	2020-08-14	Completed
The Efficacy of Intravenous Ascorbic Acid in Patients With Severe Sepsis[NCT02734147]	Phase 2	24 participants (Actual)	Interventional	2016-04-01	Terminated(stopped due to The trial prematurely terminated due to the loss of funding.)
Prospective Study of the Effect of Androgen Deprivation Therapy (ADT) in Male Patients Suffered Prostate Cancer in Asian Population[NCT03703778]		600 participants (Anticipated)	Observational	2016-05-22	Recruiting
A Randomized Phase III Study Comparing Androgen Suppression and Elective Pelvic Nodal Irradiation Followed by High Dose 3-D Conformal Boost Versus Androgen Suppression and Elective Pelvic Nodal Irradiation Followed by 125-Iodine Brachytherapy Implant Boos[NCT00175396]	Phase 3	400 participants (Anticipated)	Interventional	2004-05-31	Active, not recruiting
Physiological Effects of Gestational Diabetes on the Placenta and Neonatal Outcome; Role of Antioxidant Administration[NCT02355197]	Phase 4	200 participants (Actual)	Interventional	2013-01-31	Completed
A Phase 2 Randomized Controlled Trial of Epigallocatechin-3-Gallate (EGCG) on Frailty and Inflammation in Older Survivors of Cancer[NCT06068543]	Phase 2	118 participants (Anticipated)	Interventional	2024-01-01	Not yet recruiting
A Phase I Study of Metronomic Temozolomide and Intravenous Ascorbic Acid for Patients With Recurrent High Grade Glioma[NCT02168270]	Phase 1	4 participants (Actual)	Interventional	2014-06-16	Terminated
Risk-stratified Frontline Oral Arsenic Trioxide-based Induction in Newly Diagnosed Acute Promyelocytic Leukaemia[NCT03624270]	Phase 2	60 participants (Anticipated)	Interventional	2018-08-15	Recruiting
High-Dose Vitamin C Treatment in Critically Ill COVID-19 Patients, A Retrospective Cohort Study[NCT04710329]		78 participants (Actual)	Observational	2021-01-16	Completed
Evaluation of the Safety and Efficacy of Standard Dose Gemcitabine Combined With High Dose Intravenous Vitamin C (HDIVC) Treatment for Patients With Metastatic Adenocarcinoma of the Pancreas.[NCT01654861]	Phase 1	3 participants (Actual)	Interventional	2012-06-30	Terminated(stopped due to recruiting or enrolling participants has halted prematurely and will not resume)
Safety of Oral Antioxidants and Intravenous Vitamin C During GYN Cancer Care[NCT00284427]	Phase 2	25 participants (Actual)	Interventional	2005-09-30	Completed
A Phase I Study of Arsenic Trioxide and Ascorbic Acid (ATO/AA) in Combination With Low Dose Velcade-Thalidomide-Dexamethasone (VTD) in Relapsed/Refractory Multiple Myeloma (MM)[NCT00258245]	Phase 1	5 participants (Actual)	Interventional	2005-05-31	Completed
Phase 2 Study of Ascorbic Acid Treatment in Charcot-Marie-Tooth Type 1A[NCT00271635]	Phase 2	13 participants (Actual)	Interventional	2006-01-31	Completed
Prophylactic Administration of Vitamin C in Wrist Fractures; a Randomized Placebo Controlled Multicentre Dose-Finding Study of the Incidence of Complex Regional Pain Syndrome[NCT00296868]	Phase 4	300 participants	Interventional	2001-01-31	Completed
A Phase II Trial of Combination Therapy With Thalidomide, Arsenic Trioxide, Dexamethasone, and Ascorbic Acid (TADA) in Patients With Chronic Idiopathic Myelofibrosis or Overlap Myelodysplastic/Myeloproliferative Disorders[NCT00274820]	Phase 2	15 participants (Actual)	Interventional	2005-10-31	Completed
A Phase II Trial of Bortezomib + Ascorbic Acid + Melphalan (BAM) Combination Therapy for Patients With Newly Diagnosed Multiple Myeloma[NCT00317811]	Phase 2	35 participants (Anticipated)	Interventional	2005-11-30	Completed
Efficacy of Ascorbic Acid for Prevention of Colistin-Associated Nephrotoxicity[NCT01501968]	Phase 3	54 participants (Anticipated)	Interventional	2012-01-31	Not yet recruiting
Vitamin C: Assessing Safety After Lung Transplant[NCT04505878]	Phase 2	0 participants (Actual)	Interventional	2023-04-30	Withdrawn(stopped due to Decided not to proceed with study)
EFFICACY, TOLERABILITY, AND SAFETY OF DIFFERENT BOWEL PREPARATIONS FOR COLONOSCOPY IN CHILDREN[NCT01711437]	Phase 4	400 participants (Anticipated)	Interventional	2011-01-31	Recruiting
Placebo-controlled,Doubled,Randomized Trial Evaluating the Effect of Intravenous Ascorbic Acid on Intraoperative Blood Loss in Women Undergoing Laparoscopic Myomectomy[NCT01715597]	Phase 3	50 participants (Actual)	Interventional	2012-12-31	Completed
Randomized Controlled Trial of Low-volume PEG Plus Ascorbic Acid Versus Standard PEG Solution as Bowel Cleansing for Colonoscopy[NCT01740518]		360 participants (Anticipated)	Observational	2012-03-31	Enrolling by invitation
A Phase I Pilot Study of Samarium-153 Combined With Neoadjuvant Hormonal Therapy and Radiation Therapy in Men With Locally Advanced Prostate Cancer[NCT00328614]	Phase 1	32 participants (Actual)	Interventional	2003-03-31	Completed
The Role of Oxidative Stress and Opiorphin in Temporomandibular Disorders[NCT03029494]		80 participants (Anticipated)	Interventional	2015-10-01	Recruiting
Pharmacological Ascorbate for the Control of Metastatic and Node-Positive Pancreatic Cancer (PACMAN): A Phase II Trial[NCT01515046]	Phase 2	1 participants (Actual)	Interventional	2012-09-30	Terminated(stopped due to Standard of care changed to FOLFIRINOX; poor accrual.)
Therapies to Prevent Progression of COVID-19, Including Hydroxychloroquine, Azithromycin, Zinc, Vitamin D, Vitamin B12 With or Without Vitamin C, a Multi-centre, International, Randomized Trial: The International ALLIANCE Study[NCT04395768]	Phase 2	200 participants (Anticipated)	Interventional	2020-09-09	Recruiting
A Comparison of Solid and Soluble Forms of Cold and Influenza Remedies[NCT01332578]	Phase 4	25 participants (Actual)	Interventional	2011-05-31	Completed
Effects of Hydrolyzed Collagen and Vitamin C on Collagen Synthesis and Explosive Performance[NCT03293004]		23 participants (Actual)	Interventional	2017-09-13	Completed
Randomized Study to Evaluate the Safety and Antiviral Efficacy of Hydroxychloroquine in Patients With Newly Diagnosed COVID-19 Compared to Standard of Care Treatment[NCT04334967]	Phase 4	13 participants (Actual)	Interventional	2020-03-30	Suspended(stopped due to suspected unfavorable risk/benefit assessment)
Radiofrequency as the New Opportunity in Treating Overactive Bladder and Urgent Urinary Incontinence - a Prospective Randomized Placebo Controlled Study[NCT06080217]		80 participants (Anticipated)	Interventional	2023-07-10	Active, not recruiting
Concentrated Ascorbic Acid in DMSO for Treatment of Squamous Cell Carcinoma of the Skin[NCT05932511]	Early Phase 1	15 participants (Anticipated)	Interventional	2023-06-12	Recruiting
A Phase II Trial of Gemcitabine Plus High-Dose Ascorbate in Locally Advanced Unresectable or Metastatic Soft Tissue and Bone Sarcomas in Adults[NCT03468075]	Phase 2	10 participants (Actual)	Interventional	2018-07-11	Terminated(stopped due to Stopping rules met)
The Efficacy of High Dose Vitamin C in the Critically Ill Patient Population[NCT01587963]	Phase 2	11 participants (Actual)	Interventional	2013-02-28	Terminated(stopped due to PI's add. responsibilities and time commitment prevent him from completing trial)
IV Vitamin C With Chemotherapy for Cisplatin Ineligible Bladder Cancer Patients: A Forgotten Group[NCT04046094]	Phase 1/Phase 2	16 participants (Actual)	Interventional	2019-10-17	Active, not recruiting
An Open-Label, Three-Arm, Parallel, Investigator-Initiated Trial of Three Different Gummies (Curcumin Gummies, Vitamin C Gummies, and Vitamin B Complex Gummies) in Healthy Children[NCT05775237]		48 participants (Actual)	Interventional	2023-05-01	Completed
A Randomized Controlled Trial to Compare Prophylaxis With Oral Ascorbic Acid, Oral Amiodarone or Both in Combination With Beta Blockers to Reduce Postoperative Atrial Fibrillation After Cardiac Surgery[NCT00953212]	Phase 3	304 participants (Actual)	Interventional	2009-08-31	Completed
The Effect of Continuous Sipping of a Glucose Solution on Markers of Oxidation in Men and Women[NCT01440790]		18 participants (Actual)	Interventional	2010-08-31	Completed
Oxalate Formation From Ascorbic Acid[NCT04603898]		136 participants (Anticipated)	Interventional	2021-11-15	Recruiting
Clinical Utility of Endothelial Dysfunction in PAD[NCT00491751]	Phase 1	108 participants (Actual)	Interventional	2004-05-31	Terminated(stopped due to Insufficient enrollment)
Post Operative Atril Fibrillation : The Impact of Oral Vitamin C in Reducing the Risk in Egyptian CABG Patients[NCT06074367]	Phase 4	180 participants (Actual)	Interventional	2020-10-13	Active, not recruiting
Vitamin C to Reduce Exogenous Vasopressor Dose in Septic Shock; a Randomized Clinical Trial[NCT03835286]	Phase 3	180 participants (Anticipated)	Interventional	2019-03-01	Active, not recruiting
Comparison of 4L Polyethylene Glycol and 2L Polyethylene Glycol With Ascorbic Acid in Patients With Inactive Ulcerative Colitis; Randomized, Single Blind, Multicenter Study[NCT01929668]		114 participants (Actual)	Interventional	2013-08-31	Completed
The Effect of High Dose Parenteral Ascorbic Acid On Microcirculation In Sepsis. Randomized Double-Blind Placebo-Controlled Trial[NCT04773717]		60 participants (Actual)	Interventional	2019-01-01	Completed
The Effect of Phenolic Cmpounds in Osteoarthritis; a Nutritional Intervention[NCT04783792]		72 participants (Actual)	Interventional	2020-11-01	Completed
The Effect of Local Antioxidant Therapy on Racial Differences in Vasoconstriction[NCT03684213]	Phase 1	50 participants (Anticipated)	Interventional	2018-10-15	Recruiting
Efficacy of Novel Agents for Treatment of SARS-CoV-2 Infection Among High-Risk Outpatient Adults: An Adaptive Randomized Platform Trial[NCT04354428]	Phase 2/Phase 3	289 participants (Actual)	Interventional	2020-04-16	Terminated(stopped due to Low number of events contributing to primary outcome)
PeRiOperative VItamin C to Reduce perSistent paIn After tOtal kNee Arthroplasty (PROVISION): a Pilot Multicentre Randomized Controlled Trial[NCT06123715]	Phase 2	100 participants (Anticipated)	Interventional	2024-01-15	Not yet recruiting
SAFEty Study of Early Infusion of Vitamin C for Treatment of Novel Coronavirus Acute Lung Injury (SAFE EVICT CORONA-ALI)[NCT04344184]	Phase 2	48 participants (Actual)	Interventional	2020-12-18	Completed
Effects of Antioxidants Supplementation on Muscular Function of Patients Affected by Facioscapulohumeral Dystrophy (FSHD)[NCT01596803]		54 participants (Actual)	Interventional	2010-05-01	Completed
Ascorbic Acid (Vitamin C) Infusion in Human Sepsis[NCT01434121]	Phase 1/Phase 2	24 participants (Actual)	Interventional	2010-05-31	Completed
A Randomized Phase Ⅲ Study of IV Ascorbic Acid in Combination With FOLFOX+/- Bevacizumab vs Treatment With FOLFOX+/- Bevacizumab Alone as First-line Therapy for Advanced Colorectal Cancer[NCT02969681]	Phase 3	442 participants (Actual)	Interventional	2017-01-31	Completed
[NCT01926132]	Phase 4	60 participants (Anticipated)	Interventional	2013-08-31	Recruiting
Alcohol Abuse or Alcohol Withdrawal: Risk of Latent Scurvy: A STROBE Compliant Study[NCT03467022]		47 participants (Actual)	Observational	2014-01-02	Completed
Investigating the Oral Bioavailability of Vitamin C Administered Using Phosphycell™ Technology - a Phosphatidylcholine-lipid Encapsulation Technology.[NCT05183880]		12 participants (Anticipated)	Interventional	2021-11-26	Recruiting
"A Pilot Monocentric, Open Phase II Study to Investigate the Efficacy and Safety of a New Oral Gut Cleansing Solution (Low Dose Bowel Prep) in 30 Patients Submitted to Colonoscopy"[NCT00321230]	Phase 2	30 participants	Interventional	2001-01-31	Completed
Parallel Group Comparison of the New 2 Liter Gut Cleansing Solution NRL 994 Versus Sodium Phosphate Preparation in Routine Colon Cleansing Prior to Colonoscopies for Colon Tumor Screening.[NCT00427089]	Phase 3	360 participants (Actual)	Interventional	2004-09-30	Completed
Iron Bioavailability Study Of Fortified Oat Drink[NCT01423162]	Phase 4	21 participants (Actual)	Interventional	2011-08-31	Completed
Effects Of Combination Therapy Of Statin And Ascorbic Acid For Prevention Of Contrast-Induced Nephropathy. Randomised Controlled Study[NCT03391830]		250 participants (Actual)	Interventional	2018-01-15	Completed
Phase I/II Study of Intravenous Ascorbic Acid in Combination With Irinotecan Versus Irinotecan Alone for Advanced Colorectal Cancer[NCT01550510]	Phase 1/Phase 2	4 participants (Actual)	Interventional	2011-12-31	Terminated(stopped due to Closed: low enrollment, many treatment options available for Colorectal Cancer)
Vitamin C Infusion for Treatment in Sepsis Induced Acute Lung Injury[NCT02106975]	Phase 2	170 participants (Actual)	Interventional	2014-04-30	Completed
Phase II, Open Label Study of Intravenous Ascorbic Acid in Combination With Gemcitabine and Erlotinib in the Treatment of Metastatic Pancreatic Cancer[NCT01555489]	Phase 2	11 participants (Actual)	Interventional	2011-10-31	Terminated(stopped due to Slow accrual)
Phase I/II Study of Intravenous Ascorbic Acid in Treatment of Metastatic Hepatocellular Carcinoma[NCT01754987]	Phase 1/Phase 2	5 participants (Actual)	Interventional	2012-09-30	Completed
Targeting Endoplasmic Reticulum Stress in Aging- and Obesity-Induced Vascular Dysfunction[NCT04001647]	Early Phase 1	60 participants (Anticipated)	Interventional	2019-06-01	Suspended(stopped due to IRB approval has been withdrawn)
Phase 2 Study of Extreme Hypofractionation Including Pelvic Nodes for High Risk Prostate Cancer Using MgRT (MRI Guided Radiation Therapy)[NCT05676463]	Phase 2	88 participants (Anticipated)	Interventional	2022-11-16	Suspended(stopped due to on hold due to pause of outside company)
A Pilot Study of Intravenous Ascorbic Acid and Folfirinox in the Treatment of Advanced Pancreatic Cancer[NCT02896907]	Early Phase 1	8 participants (Actual)	Interventional	2016-10-18	Completed
N-Acetylcysteine vs. Ascorbic Acid for Prevention of Contrast Induced Nephropathy in Renal Insufficiency Undergoing Coronary Catheterization: NASPI Study-A Randomized Controlled Trial[NCT00356954]	Phase 4	250 participants	Interventional	2005-02-28	Completed
Comparison the Efficacy Depending on the Order of the Sequential Combination Method Using Sodium Picosulfate and Magnesium Citrate (PMC) and PEG With Ascorbic Acid for Bowel Preparation (The Phase II Prospective Randomized Clinical Trial)[NCT02979223]	Phase 2	142 participants (Actual)	Interventional	2016-11-30	Completed
Clinical Research of High Dose Vitamin C Combined With Metformin in the Treatment of Malignant Tumors[NCT04033107]	Phase 2	30 participants (Anticipated)	Interventional	2020-07-01	Recruiting
SHARON: Study of Metastatic Cancers in Patients With a Defect in a Homologous Recombination Gene Using Autologous Stems Cells and Potentiated Redox Cycling to Overcome Drug Resistance to Nitrogen Mustard Derivatives[NCT04150042]	Phase 1	10 participants (Anticipated)	Interventional	2021-01-13	Recruiting
A Randomized, Examiner-blind, Comparator-controlled, Cross-over Bioequivalence Study on Vitamin C in Healthy Adults[NCT03562988]		35 participants (Actual)	Interventional	2017-08-01	Completed
Radiation Enhancement of Local and Systemic Anti-Prostate Cancer Immune Responses[NCT03649841]	Phase 2	10 participants (Actual)	Interventional	2020-06-29	Terminated(stopped due to Terminated due to low accrual.)
1L Morning-only Polyethylene Glycol Plus Ascorbic Acid With Prepackaged Low-residue Diet Versus 2L Polyethylene Glycol Plus Ascorbic Acid for Bowel Preparation: a Randomized Trial[NCT03329339]		200 participants (Actual)	Interventional	2015-05-15	Completed
Targeting the Prostatic Tumor Microenvironment With PLX3397, a Tumor-Associated Macrophage Inhibitor in Men With Unfavorable Risk Prostate Cancer Undergoing Radiation Therapy and Androgen Deprivation Therapy[NCT02472275]	Phase 1	8 participants (Actual)	Interventional	2015-06-30	Completed
Iron Bioavailability From Salt Fortified With Ferrous Sulphate, Zinc Sulphate and Ascorbic Acid Encapsulated in a Polymer Jacket[NCT02353325]		20 participants (Actual)	Interventional	2016-03-31	Completed
Topical Ascorbic Acid for Treatment of Basal Cell Carcinoma[NCT04279535]	Early Phase 1	25 participants (Actual)	Interventional	2018-03-01	Completed
The Effect of Melatonin and Vitamin C on COVID-19[NCT04530539]		122 participants (Actual)	Interventional	2020-10-05	Completed
Reversing Glucose and Lipid-mediated Vascular Dysfunction (REGAL)[NCT04832009]	Early Phase 1	46 participants (Anticipated)	Interventional	2022-05-09	Recruiting
Therapeutic Use of Intravenous Vitamin C in Allogeneic Stem Cell Transplant Recipients[NCT03613727]	Phase 2	61 participants (Actual)	Interventional	2018-10-01	Completed
Vitamin C for the Prevention of Catheter-associated Urinary Tract Infections in Women Who Undergo Elective Gynecological Surgeries: a Randomized Double-blinded Controlled Trial[NCT05913180]	Phase 2	180 participants (Anticipated)	Interventional	2023-06-15	Not yet recruiting
Cabazitaxel With Abiraterone Versus Abiraterone Alone Randomized Trial for Extensive Disease Following Docetaxel: The CHAARTED2 Trial[NCT03419234]	Phase 2	223 participants (Actual)	Interventional	2018-04-26	Active, not recruiting
Double-Blind, Randomized Study of High Dose Vitamin C On Outcome in Cardiac Surgery Patients[NCT01167569]	Phase 4	57 participants (Actual)	Interventional	2007-10-31	Completed
Phase III Multicenter Randomized Trial of Adjuvant Androgen Deprivation in Combination With Three-dimensional Conformal Radiotherapy Doses in High and Intermediate Risk Localized Prostate Cancer.[NCT02175212]	Phase 3	362 participants (Actual)	Interventional	2005-11-30	Completed
A Randomized Phase 2 Trial of Ascorbic Acid in Combination With Docetaxel in Men With Metastatic Prostate Cancer[NCT02516670]	Phase 2	50 participants (Actual)	Interventional	2016-06-20	Terminated(stopped due to insufficient clinical response per DSMB)
Influence of Hesperidin and Vitamin C on Uric Acid Concentration[NCT04316390]		40 participants (Actual)	Interventional	2022-07-15	Completed
Phase 2 Trial Pembrolizumab or Pembrolizumab in Combination With Intratumoral SD-101 Therapy in Patients With Hormone-Naïve Oligometastatic Prostate Cancer Receiving Stereotactic Body Radiation Therapy and Intermittent Androgen Deprivation Therapy[NCT03007732]	Phase 2	23 participants (Actual)	Interventional	2017-05-17	Active, not recruiting
A Phase II Trial of High-Dose Ascorbate in Stage IV Non-Small Cell Lung Cancer[NCT02420314]	Phase 2	55 participants (Actual)	Interventional	2015-04-30	Active, not recruiting
Phosphate Lowering to Treat Vascular Dysfunction in Chronic Kidney Disease[NCT02209636]	Phase 4	66 participants (Actual)	Interventional	2014-09-15	Completed
Iron Sucrose Combined With rHuEPO and Ascorbic Acid on Perioperative Allogeneic Red Blood Cell Infusion in Patients Undergoing Elective Major Cardiac Surgery[NCT05353348]		370 participants (Anticipated)	Interventional	2023-02-15	Recruiting
Phase IB/II Trial of High Dose Ascorbic Acid (AA) + Nanoparticle Paclitaxel Protein Bound + Cisplatin + Gemcitabine (AA NABPLAGEM) in Patients Who Have No Prior Therapy for Their Metastatic Pancreatic Cancer[NCT03410030]	Phase 1/Phase 2	27 participants (Actual)	Interventional	2017-12-15	Completed
The Effect of Vitamin C on the Skin Prick Test Wheal Reaction[NCT05810233]		90 participants (Anticipated)	Interventional	2023-07-15	Recruiting
LS1781: Phase 2 Trial of High Dose Intravenous Ascorbic Acid as an Adjunct to Salvage Chemotherapy in Relapsed / Refractory Lymphoma and Patients With Clonal Cytopenia of Undetermined Significance[NCT03418038]	Phase 2	55 participants (Anticipated)	Interventional	2018-03-23	Recruiting
Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function[NCT01723696]	Phase 2/Phase 3	252 participants (Actual)	Interventional	2012-12-31	Completed
Pharmacologic Ascorbic Acid as an Activator of Lymphocyte Signaling for COVID-19 Treatment[NCT04363216]	Phase 2	66 participants (Anticipated)	Interventional	2020-05-31	Not yet recruiting
Prospective Study of Stereotactic Body Radiotherapy (SBRT) Following Radical Prostatectomy[NCT03541850]	Phase 2	92 participants (Actual)	Interventional	2019-01-29	Active, not recruiting
Effect of Ascorbic Acid Supplementation in Pregnancy on Anemia (AAA)[NCT03564756]		0 participants (Actual)	Interventional	2019-08-01	Withdrawn(stopped due to Difficulty with enrollment)
High-dose Intravenous Vitamin C as an Adjunctive Treatment for Sepsis in Rwanda: a Feasibility Trial[NCT04088591]	Phase 3	0 participants (Actual)	Interventional	2022-10-31	Withdrawn(stopped due to Recent studies suggest an increase in mortality due to high-does Vitamin C)
Safety and Efficacy of Preoperative IMRT (Intensity-modulated Radiation Therapy) With Concurrent High-dose Intravenous Vitamin C and mFOLFOX6 in Locally Advanced Rectal Cancer Patients: a Prospective Study.[NCT04801511]	Phase 2	60 participants (Anticipated)	Interventional	2021-03-08	Recruiting
Contributions of Nitric Oxide Synthase, Cyclooxygenase, and Reactive Oxygen Species to Regional Cerebrovascular Control During Hypoxia and Hypercapnia[NCT03066115]	Phase 1	0 participants (Actual)	Interventional	2020-12-01	Withdrawn(stopped due to This study was never funded, never fully IRB approved, and thus never enrolled anyone.)
Daily vs. Every Other Day Oral Iron Supplementation in Patients With Absolute Iron Deficiency Anemia (DEODO): a Multi-centered, Pilot Randomized Controlled Trial[NCT03725384]	Phase 3	52 participants (Actual)	Interventional	2019-01-04	Completed
Phase I/II Study of the Combination of Arsenic Trioxide With Ascorbic Acid and High-Dose Melphalan for Patients With Multiple Myeloma[NCT00661544]	Phase 1/Phase 2	48 participants (Actual)	Interventional	2004-03-31	Completed
Phase 2/3 Study of Dose-escalated External Beam Radiation Therapy With or Without Chemotherapy for High Risk Adenocarcinoma of the Prostate[NCT01603420]	Phase 2/Phase 3	2 participants (Actual)	Interventional	2012-07-31	Terminated(stopped due to enrollment goals not met)
A Randomized, Double Blind, Placebo-Controlled Study to Investigate the Effects of Vitamin C, Hydrocortisone and Thiamine on the Outcome of Patients With Severe Sepsis and Septic Shock[NCT03335124]	Phase 4	5 participants (Actual)	Interventional	2017-09-26	Terminated(stopped due to Due to insufficient recruitment)
Antioxidants Vitamins and Muscle Damage[NCT05127928]		18 participants (Actual)	Interventional	2022-02-10	Completed
Effect of Antioxidant Vitamins on Coagulopathy and Nosocomial Pneumonia After Severe Trauma[NCT01897792]	Phase 2	11 participants (Actual)	Interventional	2013-05-31	Terminated(stopped due to Inability to recruit patients that meet inclusion criteria.)
Phase 4 Study of High Dose Vitamin C in Chronic Hepatitis Patients[NCT01413360]	Phase 4	10 participants (Actual)	Interventional	2011-08-31	Completed
The Effect of Vitamin C and E Therapy on Restless Leg Syndrome in Patients With End Stage Renal Disease on Haemodialysis[NCT05350124]	Phase 3	160 participants (Anticipated)	Interventional	2022-11-30	Not yet recruiting
Antioxidant Activity and Lipid Peroxidation Status in Patients HIV+ Supplemented With Microencapsulated of Red Pomegranate[NCT03531749]		60 participants (Actual)	Interventional	2017-01-31	Completed
Hyperoxia and Antioxidants During Major Non-cardiac Surgery and Risk of Cardiovascular Complications, a Blinded 2x2 Factorial Randomised Clinical Trial[NCT03494387]	Phase 4	600 participants (Actual)	Interventional	2018-04-06	Completed
An Observational, Retrospective and Multicenter Study to Evaluate the Effectiveness and Safety of 1L (PEG)+ Ascorbic Acid Given for Bowel Preparation Prior to Colonoscopy in Iberia[NCT05174845]		13,393 participants (Actual)	Observational	2021-10-01	Completed
Can Yeast Cells Emulate Vitamin E on In-vitro Protection of Human Spermatozoa Against Oxidative Stress?[NCT02814695]	Phase 1	40 participants (Actual)	Interventional	2020-08-15	Completed
Effect of Resveratrol and Vitamin C on Insulin Resistance and Antioxidant Capacity in Postmenopausal Women. A Randomized Clinical Trial[NCT03090997]		45 participants (Anticipated)	Interventional	2018-02-15	Active, not recruiting
Phase II Trial of Primary Radiotherapy With Androgen Ablation With or Without Adjuvant Niraparib for Selected High-Risk Locoregional Prostate Cancer[NCT04947254]	Phase 2	200 participants (Anticipated)	Interventional	2021-08-05	Recruiting
Pharmacological Ascorbate Combined With Radiation and Temozolomide in Glioblastoma Multiforme: A Phase 2 Trial[NCT02344355]	Phase 2	90 participants (Anticipated)	Interventional	2017-03-13	Active, not recruiting
Difference in Mortality and Evolution in Septic Patients Treated With Vitamin C, Tiamine, Cyanocobalamine, Pyridoxine and Hydrocortisone Treated at the ICU of General Hospital Zone 11 IMSS Piedras Negras Coahuila.[NCT04197115]	Phase 3	19 participants (Actual)	Interventional	2019-09-01	Completed
Tolerability and Efficacy of Low-Volume Sodium Picosulfate/Magnesium Citrate Versus 2L Polyethylene Glycol/Ascorbic Acid in Patients With Ulcerative Colitis Undergoing Colonoscopy: A Randomized Controlled Trial[NCT03581149]	Phase 4	68 participants (Anticipated)	Interventional	2018-03-26	Recruiting
Randomized Controlled Double-blinded Clinical Trial of an Herbal Mouthrinse for Radiotherapy Induced Mucositis in Cancer Patients[NCT01898091]	Phase 2	50 participants (Actual)	Interventional	2013-07-31	Completed
Advancing the Cardiovascular Science of Vitamin C in Cardiac Surgery Patients[NCT03123107]	Phase 1	6 participants (Actual)	Interventional	2017-07-06	Completed
Impact of Low Fiber Diet on Colonic Cleansing Quality Prior to Colonoscopy: Randomized Study Comparing 1 Day Versus 3 Days of Low Fiber Diet[NCT03247452]		404 participants (Actual)	Interventional	2017-12-18	Completed
Evaluation of Dermatological Safety of Test Products by 24 Hours Patch Test Under Complete Occlusion or Semi Occlusion or Open Patch on Adult Healthy Human Subjects[NCT05642702]		26 participants (Anticipated)	Interventional	2022-12-05	Not yet recruiting
Early Administration of Vitamin C in Patients With Sepsis or Septic Shock in Emergency Departments: a Multicentre, Double Blinded, Randomized Controlled Trial: the C-EASIE Trial[NCT04747795]	Phase 3	301 participants (Actual)	Interventional	2021-06-01	Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Ejection Fraction: Percentage of Blood Leaving the Heart Before and After Exercise at Baseline, After a Vitamin C Infusion, and After Exercise Training

Evaluate potential changes in cardiac function by echocardiography following 2 interventions: Three months of exercise training and acute vitamin C administration. Ejection fraction (EF) is a measurement of the percentage of blood leaving your heart each time it contracts, typically measure by echocardiography. Numbers listed are absolute EF values. (NCT00786019)
Timeframe: 7 months; Measures are made at rest for baseline, at rest for Vitamin C administration, and at rest following the exercise training

Intervention	percentage of blood leaving the heart (Mean)
	Baseline	Vitamin C	Post Exercise Training
Ejection Fraction - Control	65	67	61
Ejection Fraction - Type 2 Diabetes	65	63	65

Intervention	ng/mL (Mean)
Intervention 1 (500 mg)	13372
Intervention 2 (1000 mg)	16079
Control (Placebo)	13111

Intervention	ng/mL (Mean)
Intervention 1 (500 mg)	21309
Intervention 2 (1000 mg)	20574
Control (Placebo)	12537

Intervention	L/min (Mean)
	Baseline	Month 3
Control (Placebo)	5.6	14.2
Intervention 1 (500 mg)	6.9	12.7

Intervention	pg/mL (Mean)
	Baseline	3 months
Control (Placebo)	13832	2580
Intervention 1 (500 mg)	23144	507
Intervention 2 (1000 mg)	10406	2431

Intervention	gram (Least Squares Mean)
	Change from Baseline in Lean Body Mass (g) to Week 16	Change from Baseline in Fat Mass (g) to Week 16
Drug Group 1	1610.3	-1468.7
Drug Group 2	1961.6	-1491.3
Other	37.8	-198.2

Intervention	percentage of subjects (Number)
Arm1: Androgen Suppression Therapy + Radiation Therapy	48
Arm2: Docetaxel + Androgen Suppression Therapy + Radiation Therapy	54

Intervention	years (Mean)
Arm1: Androgen Suppression Therapy + Radiation Therapy	8.82
Arm2: Docetaxel + Androgen Suppression Therapy + Radiation Therapy	9.11

Intervention	Participants (Count of Participants)
	24 hours	48 hours	72 hours	96 hours
Intervention	12	16	18	18
Placebo	13	18	18	19

Intervention	liters (Mean)
	6 hours post initiation of study treatment	24 hours post initiation of study treatment
Intervention	1.07	3.59
Placebo	.76	3.37

Intervention	Units on a scale (Mean)
	Enrollment SOFA score	72 hour SOFA score
Placebo	9.2	5.1
Vitamin C, Vitamin B1, Corticosteroids	9.1	4.4

Intervention	mg/dL (Mean)
Mild Hypoxemia	-3.8
Severe Hypoxemia	-2.0

Intervention	ug/mL (Mean)
Mild Hypoxemia	-0.21
Severe Hypoxemia	3.71

Intervention	days (Median)
Mild Hypoxemia	21.5
Severe Hypoxemia	8.5

Intervention	days (Median)
Mild Hypoxemia	28
Severe Hypoxemia	13.5

Intervention	Months (Median)
Arm A (Pazopanib Hydrochloride, Ascorbic Acid)	5.9
Arm B (Pazopanib Hydrochloride)	9.2

Intervention	Months (Median)
Arm A (Pazopanib Hydrochloride, Ascorbic Acid)	5.7
Arm B (Pazopanib Hydrochloride)	11.8

Intervention	Participants (Count of Participants)
Dietary Supplement/Vitamins	1
Placebo for Vitamin C and Vitamin E	1

Intervention	Participants (Count of Participants)
	All Fetal or Neonatal Deaths	Fetal loss at < 20 weeks	Fetal death at ≥20 weeks	Neonatal death
Placebo	122	59	36	27
Vitamins	113	55	38	20

Intervention	Participants (Count of Participants)
	Total Preeclampsia	Mild Preeclampsia	Severe Preeclampsia	HELLP Syndrome	Eclampsia
Placebo	332	191	129	8	4
Vitamins	358	212	134	2	10

Intervention	Participants (Count of Participants)
	<37 weeks' gestation	<32 weeks' gestation
Placebo	526	173
Vitamins	513	149

Intervention	Participants (Count of Participants)
Phase I: Ascorbate 75 mg IV Infusion	2
Phase II: Ascorbate 75 mg IV Infusion	1

Intervention	nM*hr (Mean)
Sapropterin Dihydrochloride	440
Sapropterin Dihydrochloride+Vitamin C	440

Intervention	nM*hr (Mean)
Sapropterin Dihydrochloride 10 mg/kg	633
Sapropterin Dihydrochloride+Vitamin C 10 mg/kg	993

Intervention	pmol/mL (Mean)
	Baseline	Change from Baseline to Day 14	Change from Day 14 to Day 28
Sapropterin Dihydrochloride 10mg/kg Vitamin C	3.7941	0.6278	-0.0507
Sapropterin dihydrochloride10mg/kg and Vitamin C	3.8533	0.2088	-0.0078

ascorbic acid

Description

Related Flora

Cross-References

Synonyms (343)

Roles (8)

Drug Classes (2)

Pathways (29)

Protein Targets (36)

Potency Measurements

Inhibition Measurements

Activation Measurements

Other Measurements

Biological Processes (72)

Molecular Functions (40)

Ceullar Components (27)

Bioassays (1029)

Research

Studies (41,924)

Study Types

Clinical Trials (344)

Trial Overview

Trial Outcomes

Ejection Fraction: Percentage of Blood Leaving the Heart Before and After Exercise at Baseline, After a Vitamin C Infusion, and After Exercise Training

Percent Change in Circumferential Strain Before and After Exercise at Baseline, After Vitamin C Infusion, and After Exercise Training

All-cause Mortality

C-reactive Protein (CRP)

Change in S/F Ratio During High Dose Intravenous Vitamin C (HDIVC)

D-dimer

Hospital-free Days

Intensive Care Unit (ICU)-Free Days

Lactate Dehydrogenase (LDH)

Lymphocyte Count

Neutrophil to Lymphocyte Ratio (NLR)

Number of Participants With Adverse Events Related to High Dose Intravenous Vitamin C (HDIVC)

Number of Participants With Adverse Reactions

Number of Participants With Serious Adverse Reactions

Serum Ferritin

Ventilator-free Days

Serum Vitamin C Level at Baseline

Serum Vitamin C Level at Month 3

Cardiac Function

Health Related Quality of Life Scores

Oxidative Stress

Total MSAS-HF Score

Change From Baseline in PSA (%) to Week 16

International Prostate Symptom Score- IPSS

To Evaluate the Effect of OPK-88004 on Uroflowmetry Parameter- Mean Flow Rate (Qave)

To Evaluate the Effect of OPK-88004 on Uroflowmetry Parameter- Peak Flow Rate (Qmax)

To Evaluate the Effect of OPK-88004 on Uroflowmetry Parameter- Postvoid Residual Volume (PVR)

To Evaluate the Effect of OPK-88004 on Uroflowmetry Parameter-voided Volume (Vcomp)

Absolute Change in Lean Body Mass and Fat Mass From Baseline to 16 Weeks

10-year Biochemical Recurrence (PSA Failure)

10-year Prostate Cancer Mortality

10-Year Restricted Mean Survival Time for Overall Survival

Number of Participants With Acute Adverse Events

Number of Participants With Late Adverse Events, Any Grade and Attribution

Hospital Length of Stay

Hours on Vasopressors

Intensive Care Unit Length of Stay

Mortality Rates

Readmission Rate

Ventilator Days

All Cause Mortality at 28 Days

Change in Acute Physiology and Chronic Health Evaluation (APACHE) Scores

Change in Sequential Organ Failure Assessment (SOFA) Score

Change in Serum Creatinine

Duration of ICU Stay Post Intervention Administration

Duration of Vasopressor Therapy

Number of Participants With ICU Mortality

Number of Participants With Need for Renal Replacement Therapy

Rate of Lactate Clearance Post Intervention Administration

Total Intravenous Fluid Administered

Change in Sequential Organ Failure Assessment (SOFA) Score

Hospital Length of Stay

Hospital Mortality

ICU Length of Stay

ICU Mortality

Procalcitonin (PCT) Clearance

Time to Vasopressor Independence (Hours)

Intervention	mm Hg (Mean)
	Baseline	Change from Baseline to Day 13	Change from Day 13 to Day 27
Sapropterin Dihydrochloride 10mg/kg and Vitamin C	80.15	0.45	1.23
Sapropterin dihydrochloride10mg/kg	77.32	-2.31	-2.01

Intervention	Ratio (Mean)
	Baseline	Day 13	Change from Baseline to Day 13	Day 27	Change from Day 13 to Day 27
Sapropterin Dihydrochloride 10mg/kg	1.5113	1.8509	0.3467	1.9047	0.1293
Sapropterin Dihydrochloride 10mg/kg and Vitamin C	1.4859	1.7754	0.2902	1.6482	-0.1641

Intervention	Participants (Count of Participants)
	Baseline < 30 mg/g	Baseline >=30 mg/g	Day 14 < 30 mg/g	Day 14 >=30 mg/g	Day 28 < 30 mg/g	Day 28 >=30 mg/g
Sapropterin Dihydrochloride 10mg/kg	13	1	10	2	12	1
Sapropterin Dihydrochloride 10mg/kg and Vitamin C	16	2	13	1	10	2

Intervention	Participants (Count of Participants)
	Subjects with any Adverse Event	Subjects with any Serious Adverse Event	Subjects with any treatment-related Adverse Event	Any treatment-related Serious Adverse Event	Death	Any AEs Leading to Study Discontinuation
Sapropterin Dihydrochloride	19	0	16	0	0	1
Sapropterin Dihydrochloride+Vitamin C	16	0	13	0	0	0

Intervention	ratio (Mean)
	BH2	B	Calculated BH4 (from Total Biopterin)
(Sapropterin Dihydrochloride+Vitamin C)/(Sapropterin Dihydrochloride)	0.998	1.04	1.03

Intervention	score on a scale (Mean)
	All patients	Patients alive at 4 weeks
Placebo	-2.9	-2.4
Vitamin C Infusion (Ascorbic Acid)	-0.13	-2.3

Intervention	Participants (Count of Participants)
	Number of participants with crystalluria at baseline	Number of patients with crystalluria at Day 4
Placebo	0	0
Vitamin C Infusion (Ascorbic Acid)	0	0

Intervention	m/s (Mean)
	Baseline	Baseline + Vit C	Pre-inflammation	Inflammation	Inflammation + Vit C
Older Adults	9.3	9.9	8.8	8.8	8.9
Younger Adults	5.8	5.9	5.6	5.6	5.7

Intervention	% change in diameter (Mean)
	Baseline	Baseline + Vit C	Pre-Inflammation Baseline	Inflammation	Inflammation + Vit C
Older Adults	2.4	3.4	3.4	1.6	2.8
Younger Adults	5.5	5.7	6.3	5.8	6.1

Intervention	participants (Number)
	CR	CRi	Treatment Failure	Not Evaluable
Arsenic Trioxide (ATO) Plus Ascorbic Acid	1	5	4	1