Proteins > Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
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Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
A protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha that is encoded in the genome of cow. [OMA:P29702, PRO:DNx]
Synonyms
EC 2.5.1.58;
EC 2.5.1.59;
CAAX farnesyltransferase subunit alpha;
FTase-alpha;
Ras proteins prenyltransferase subunit alpha;
Type I protein geranyl-geranyltransferase subunit alpha;
GGTase-I-alpha
Research
Bioassay Publications (10)
Timeframe | Studies on this Protein(%) | All Drugs % |
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 2 (20.00) | 18.2507 |
2000's | 8 (80.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Compounds (8)
Drugs with Inhibition Measurements
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
b 581 | Bos taurus (cattle) | IC50 | 0.0210 | 1 | 1 |
r115777 | Bos taurus (cattle) | IC50 | 0.5503 | 2 | 4 |
lonafarnib | Bos taurus (cattle) | IC50 | 4.0049 | 5 | 5 |
tipifarnib | Bos taurus (cattle) | IC50 | 1.6003 | 9 | 9 |
l 778,123 | Bos taurus (cattle) | IC50 | 0.0485 | 2 | 2 |
fti 276 | Bos taurus (cattle) | IC50 | 0.0005 | 1 | 1 |
a 228839 | Bos taurus (cattle) | IC50 | 0.0011 | 3 | 3 |
lonafarnib | Bos taurus (cattle) | IC50 | 5.0041 | 2 | 4 |
Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity.Bioorganic & medicinal chemistry letters, , Jun-02, Volume: 15, Issue:11, 2005
Design, synthesis, and activity of achiral analogs of 2-quinolones and indoles as non-thiol farnesyltransferase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 15, Issue:8, 2005
Design, synthesis, and activity of achiral analogs of 2-quinolones and indoles as non-thiol farnesyltransferase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 15, Issue:8, 2005
Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase.Bioorganic & medicinal chemistry letters, , Apr-07, Volume: 13, Issue:7, 2003
Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity.Bioorganic & medicinal chemistry letters, , Jun-02, Volume: 15, Issue:11, 2005
Design, synthesis, and activity of achiral analogs of 2-quinolones and indoles as non-thiol farnesyltransferase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 15, Issue:8, 2005
Synthesis and activity of 1-aryl-1'-imidazolyl methyl ethers as non-thiol farnesyltransferase inhibitors.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase.Bioorganic & medicinal chemistry letters, , Apr-07, Volume: 13, Issue:7, 2003
Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase.Bioorganic & medicinal chemistry letters, , Jan-03, Volume: 15, Issue:1, 2005
Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives.Bioorganic & medicinal chemistry letters, , Apr-07, Volume: 13, Issue:7, 2003
Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase.Bioorganic & medicinal chemistry letters, , Apr-07, Volume: 13, Issue:7, 2003
Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity.Bioorganic & medicinal chemistry letters, , Jun-02, Volume: 15, Issue:11, 2005
Design, synthesis, and activity of achiral analogs of 2-quinolones and indoles as non-thiol farnesyltransferase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 15, Issue:8, 2005