Neuronal acetylcholine receptor subunit beta-4

A neuronal acetylcholine receptor subunit beta-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30926]

Synonyms

Research

Bioassay Publications (53)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	3 (5.66)	18.2507
2000's	16 (30.19)	29.6817
2010's	29 (54.72)	24.3611
2020's	5 (9.43)	2.80

Compounds (34)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
bupropion	Homo sapiens (human)	IC50	4.2771	8	8
3-(1-methylpyrrolidin-2-yl)pyridine	Homo sapiens (human)	Ki	0.0050	1	1
epibatidine	Homo sapiens (human)	Ki	0.0002	7	7
decamethonium	Homo sapiens (human)	IC50	1.7000	1	1
mecamylamine	Homo sapiens (human)	IC50	4.0714	4	7
ondansetron	Homo sapiens (human)	IC50	27.0000	1	1
indopan	Homo sapiens (human)	Ki	10.0000	3	3
cytisine	Homo sapiens (human)	Ki	0.7664	7	7
anabaseine	Homo sapiens (human)	Ki	0.1070	1	1
polygodial	Homo sapiens (human)	IC50	48.2000	1	1
nicotine	Homo sapiens (human)	IC50	0.7150	2	2
nicotine	Homo sapiens (human)	Ki	0.3463	22	22
philanthotoxin 343	Homo sapiens (human)	IC50	0.0076	1	1
varenicline	Homo sapiens (human)	IC50	0.5550	2	2
varenicline	Homo sapiens (human)	Ki	0.0902	3	3
pozanicline	Homo sapiens (human)	Ki	10.0000	1	1
tropisetron	Homo sapiens (human)	IC50	1.8000	1	1
epibatidine	Homo sapiens (human)	Ki	0.0001	1	1
trans-metanicotine	Homo sapiens (human)	Ki	5.4000	1	1
ar-r 17779	Homo sapiens (human)	IC50	1,000.0000	1	1
3-(2,4-dimethoxybenzylidene)anabaseine	Homo sapiens (human)	Ki	2.5000	2	2
mg 624	Homo sapiens (human)	Ki	0.4330	1	1
radafaxine	Homo sapiens (human)	IC50	20.2000	4	4
pnu-282987	Homo sapiens (human)	IC50	60.0000	1	1
pnu-282987	Homo sapiens (human)	Ki	60.0000	1	1
pnu-282987	Homo sapiens (human)	IC50	60.0000	1	1
3-bromocytisine	Homo sapiens (human)	IC50	0.0156	1	1
a-582941	Homo sapiens (human)	Ki	4.7000	1	1
n,n-diallyl-5-methoxytryptamine	Homo sapiens (human)	Ki	10.0000	3	3
3-(4-hydroxy-2-methoxybenzylidene)anabaseine	Homo sapiens (human)	Ki	0.9700	2	2

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
epibatidine	Homo sapiens (human)	EC50	0.0172	5	6
epibatidine	Homo sapiens (human)	Kd	0.0003	1	1
tilorone	Homo sapiens (human)	EC50	10.0000	2	2
cytisine	Homo sapiens (human)	EC50	26.0000	1	1
nicotine	Homo sapiens (human)	EC50	13.6576	14	15
3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole	Homo sapiens (human)	EC50	64.0000	1	1
varenicline	Homo sapiens (human)	EC50	1.5333	3	3
epibatidine	Homo sapiens (human)	Kd	0.0003	1	1
hmr 3647	Homo sapiens (human)	EC50	132.0000	1	1
abt 594	Homo sapiens (human)	EC50	0.1900	1	1
trans-metanicotine	Homo sapiens (human)	EC50	46.0000	1	1
a 85380	Homo sapiens (human)	EC50	0.7000	1	1
3-(2,4-dimethoxybenzylidene)anabaseine	Homo sapiens (human)	EC50	10.0000	2	2
a 84543	Homo sapiens (human)	EC50	19.4000	1	1
ispronicline	Homo sapiens (human)	EC50	10.0000	2	2

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
bupropion	Homo sapiens (human)	Concentration	14.0000	1	1
3-(1-methylpyrrolidin-2-yl)pyridine	Homo sapiens (human)	ED50	14.0000	1	1
epibatidine	Homo sapiens (human)	Activity	0.0050	1	1
epibatidine	Homo sapiens (human)	ED50	0.0190	1	1
epibatidine	Homo sapiens (human)	INH	0.0003	1	1
mecamylamine	Homo sapiens (human)	Concentration	1.6200	1	3

Enables

This protein enables 4 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ligand-gated monoatomic ion channel activity	molecular function	Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]
acetylcholine receptor activity	molecular function	Combining with an acetylcholine receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]
acetylcholine-gated monoatomic cation-selective channel activity	molecular function	Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine. [GOC:mah, PMID:2466967]

Located In

This protein is located in 6 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
specific granule membrane	cellular component	The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. [GOC:bf, PMID:7334549]
postsynaptic membrane	cellular component	A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. [ISBN:0198506732]
tertiary granule membrane	cellular component	The lipid bilayer surrounding a tertiary granule. [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036]
cholinergic synapse	cellular component	A synapse that uses acetylcholine as a neurotransmitter. [GOC:dos]

Active In

This protein is active in 3 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
neuron projection	cellular component	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
synapse	cellular component	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
acetylcholine-gated channel complex	cellular component	A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding. [GOC:bf, GOC:mah, PMID:12381728, PMID:15579462]

Involved In

This protein is involved in 16 target(s):

Target	Category	Definition
monoatomic ion transport	biological process	The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai]
smooth muscle contraction	biological process	A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732]
regulation of smooth muscle contraction	biological process	Any process that modulates the frequency, rate or extent of smooth muscle contraction. [GOC:go_curators]
signal transduction	biological process	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
synaptic transmission, cholinergic	biological process	The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:dos, Wikipedia:Cholinergic]
locomotory behavior	biological process	The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. [GOC:dph]
neuronal action potential	biological process	An action potential that occurs in a neuron. [GOC:dph, GOC:isa_complete, GOC:tb]
monoatomic ion transmembrane transport	biological process	A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:mah]
behavioral response to nicotine	biological process	Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus. [GOC:bf, ISBN:0198506732]
regulation of neurotransmitter secretion	biological process	Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell. [GOC:ai]
positive regulation of transmission of nerve impulse	biological process	Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. [GOC:ai]
excitatory postsynaptic potential	biological process	A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. [GOC:dph, GOC:ef]
synaptic transmission involved in micturition	biological process	The process of communication from a neuron to a smooth muscle in the bladder that contributes to the expulsion of urine from the body. [GOC:dph, PMID:15827347]
chemical synaptic transmission	biological process	The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435]
acetylcholine receptor signaling pathway	biological process	The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands. [GOC:mah]
membrane depolarization	biological process	The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:dh, Wikipedia:Depolarization]