Proteins > Lanosterol 14-alpha demethylase
Page last updated: 2024-08-07 18:07:55
Lanosterol 14-alpha demethylase
A lanosterol 14-alpha demethylase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16850]
Synonyms
LDM;
EC 1.14.14.154;
CYPLI;
Cytochrome P450 51A1;
Cytochrome P450-14DM;
Cytochrome P45014DM;
Cytochrome P450LI;
Sterol 14-alpha demethylase
Research
Bioassay Publications (4)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (27)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| fluconazole | Homo sapiens (human) | Kd | 76.6667 | 3 | 3 |
| ketoconazole | Homo sapiens (human) | Kd | 2.7400 | 3 | 3 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| lanosterol | Homo sapiens (human) | Km | 30.0000 | 1 | 1 |
Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae.Antimicrobial agents and chemotherapy, , Volume: 53, Issue:3, 2009
Novel cholesterol biosynthesis inhibitors targeting human lanosterol 14alpha-demethylase (CYP51).Bioorganic & medicinal chemistry, , Jan-01, Volume: 16, Issue:1, 2008
Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors.Drug metabolism and disposition: the biological fate of chemicals, , Volume: 35, Issue:3, 2007
Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae.Antimicrobial agents and chemotherapy, , Volume: 53, Issue:3, 2009
Novel cholesterol biosynthesis inhibitors targeting human lanosterol 14alpha-demethylase (CYP51).Bioorganic & medicinal chemistry, , Jan-01, Volume: 16, Issue:1, 2008
Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors.Drug metabolism and disposition: the biological fate of chemicals, , Volume: 35, Issue:3, 2007
Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering.Journal of medicinal chemistry, , Jul-23, Volume: 36, Issue:15, 1993
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|
| iron ion binding | molecular function | Binding to an iron (Fe) ion. [GOC:ai] |
| sterol 14-demethylase activity | molecular function | Catalysis of the reaction: a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = a delta14 steroid + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH-hemoprotein reductase]. [RHEA:54028] |
| heme binding | molecular function | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:ai] |
| oxidoreductase activity | molecular function | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. [GOC:go_curators] |
Located In
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
Involved In
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|
| steroid biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. [GOC:go_curators] |
| cholesterol biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:ai] |
| sterol metabolic process | biological process | The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. [ISBN:0198547684] |
| negative regulation of protein catabolic process | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process. [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082] |
| negative regulation of protein secretion | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. [GOC:ai] |
| negative regulation of amyloid-beta clearance | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta clearance. [GOC:BHF, GOC:TermGenie] |