Compounds > eusol
Page last updated: 2024-10-15

eusol

Description

Eusol: consists of a chlorinated lime and boric acid solution containing 0.25% weight/volume of available chlorine (pH 7.5-8.5) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID131750171
MeSH IDM0083024

Synonyms (2)

Synonym
8047-82-3
eusol

Research Excerpts

Overview

Eusol is an effective antibacterial agent and also assists in slough separation.

ExcerptReference
"Eusol is an effective antibacterial agent and also assists in slough separation."( Exposure-Eusol treatment for burn wounds.
Shah, A, 1985)

Toxicity

ExcerptReference
"The storage of corneal tissues in Corneal Chamber at 2-8°C for 14 days and the corneal rinse with 30 ml of PSS-L at RT for 1 min are safe and effective procedures allowing the preservation of the corneal quality parameters including ECD, endothelial mortality, endothelial morphology, HEX%, CV%, and corneal transparency and the elimination of gentamicin sulfate from the tissues before transplantation."( P14-A117 Assessment of performance and safety of corneal chamber hypothermic storage and PSS-L corneal rinsing in human and porcine corneas.
Gatto, C; Giurgola, L; Rodella, U; Rossi, O; Tóthová, JD, 2023)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (42)

TimeframeStudies, This Drug (%)All Drugs %
pre-199010 (23.81)18.7374
1990's19 (45.24)18.2507
2000's9 (21.43)29.6817
2010's2 (4.76)24.3611
2020's2 (4.76)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials10 (19.61%)5.53%
Reviews4 (7.84%)6.00%
Case Studies5 (9.80%)4.05%
Observational0 (0.00%)0.25%
Other32 (62.75%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Clinical Trials (51)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Clinical Evaluation of an Experimental Solution Based on Ricinus Communis Compared to Sodium Hypochlorite for Denture Cleansing[NCT02407834]Phase 464 participants (Actual)Interventional2012-08-31Completed
The Impact of Dilute Bleach Compresses on the Incidence and Severity of Radiation Dermatitis[NCT04851522]Early Phase 10 participants (Actual)Interventional2021-06-09Withdrawn(stopped due to Lack of patient accrual in the past year.)
Assessment of Postoperative Pain and Antibacterial Activity of Chitosan Nanoparticles Versus Sodium Hypochlorite as a Root Canal Irrigant in Infected Root Canal[NCT03719261]Phase 2/Phase 324 participants (Anticipated)Interventional2018-11-30Not yet recruiting
Prospective Evaluation of Wound Management Using Vacuum Assisted Instillation Therapy in Emergent Contaminated Abdominal Surgeries[NCT02127164]20 participants (Actual)Interventional2014-05-31Completed
Postoperative Pain After Using Er,Cr: YSGG Laser Irradiation Versus NaOCl Irrigation: A Randomized Controlled Clinical Trial[NCT03783520]170 participants (Actual)Interventional2014-11-30Completed
Effect of Irrigants on Outcome of Non Surgical Endodontic Retreatment: A Randomised Controlled Trial[NCT03719404]103 participants (Actual)Interventional2016-10-31Completed
A Feasibility Study to Evaluate a Skin Cleansing Regimen With a Sodium Hypochlorite Wash in Lower Extremity Arterial Bypass Graft Surgery or Femoral Endarterectomy[NCT03534388]0 participants (Actual)Interventional2018-05-10Withdrawn(stopped due to Enrollment difficulty)
Effect of Moringa Oleifera Leaf Extract Versus Sodium Hypochlorite as Root Canal Irrigant on Postoperative Pain and Bacterial Reduction in Mandibular Premolars With Necrotic Pulps: A Randomized Clinical Trial[NCT05348824]Phase 2/Phase 330 participants (Anticipated)Interventional2022-08-31Not yet recruiting
Acceptability and Effectiveness of Household Water Chlorination in Reducing the Prevalence of Diarrhea Among Under Five Children in Eastern Ethiopia[NCT01376440]Phase 1845 participants (Actual)Interventional2011-06-30Completed
A Clinical Use of Er,Cr:YSGG Laser: an Anti-biofilm Treatment[NCT05959629]76 participants (Anticipated)Interventional2023-11-30Recruiting
Effectiveness of Papain-based Materials Compared With NaOCl-based Materials in Chemo-mechanical Caries Removal: A Randomized Controlled Trial[NCT05733923]90 participants (Anticipated)Interventional2023-02-25Recruiting
Postoperative Pain After Endodontic Irrigation Using 1.3% Versus 5.25% Sodium Hypochlorite[NCT03792217]308 participants (Actual)Interventional2011-07-31Completed
Evaluation of the Effect of Different Cleaning and Disinfection Procedures on the Involvement of Candida Species[NCT03894839]60 participants (Actual)Interventional2017-10-26Completed
Effect of Neem (Azadirachta Indica) Versus 2.5% Sodium Hypochlorite as Root Canal Irrigants on the Intensity of Post-operative Pain and Amount of Endotoxins in Necrotic Teeth[NCT03312153]50 participants (Anticipated)Interventional2019-08-01Not yet recruiting
Nanozyme-mediated Catalysis for Clinical Treatment of Biofilm Infections[NCT06110494]Phase 444 participants (Actual)Interventional2020-07-13Completed
Comparative Evaluation of Propolis and Sodium Hypochlorite as Endodontic Irrigants on Post-Operative Pain in Patients With Symptomatic Irreversible Pulpitis[NCT05974748]Phase 344 participants (Actual)Interventional2023-04-01Completed
Efficacy of 0.005% Sodium Hypochlorite Final Rinse Solution on the Reduction of Staphylococcus Aureus Colonization in Atopic Dermatitis: A Randomized Controlled Trial[NCT02241174]Phase 10 participants (Actual)Interventional2014-07-31Withdrawn(stopped due to study materials have expired, no patients were enrolled)
Evaluation of Irrigation Effectiveness for Gel and Solution of Chlorhexidine in Disinfection Root Canals of Primary Anterior Teeth.[NCT05361278]15 participants (Actual)Interventional2021-01-15Completed
Assessment of Post Operative Pain Following Root Canal Retreatment in Molars Using Four Different Combination of Irrigants : A Prospective Clinical Study[NCT04250519]Phase 1150 participants (Anticipated)Interventional2020-02-03Recruiting
Effect of Irrigation With Antibiotic-containing Solutions Versus Sodium Hypochlorite on Postoperative Pain and Intra-canal Bacteria in Teeth With Necrotic Pulps (a Randomized Double-blind Clinical Trial)[NCT04035070]Phase 451 participants (Anticipated)Interventional2021-01-31Not yet recruiting
Effect Of Propolis Nanoparticles Versus Sodium Hypochlorite As Root Canal Irrigant On Postoperative Pain And Bacterial Reduction In Mandibular Premolars With Necrotic Pulps (A Randomized Clinical Trial)[NCT05146713]Phase 2/Phase 344 participants (Anticipated)Interventional2022-01-31Not yet recruiting
Effect of Using Etidronate in Sodium Hypochlorite Versus Sodium Hypochlorite Irrigating Solution on the Intensity of Postoperative Pain and Bacterial Load Reduction in Patients With Necrotic Pulp: A Randomized Clinical Trial[NCT04035330]34 participants (Anticipated)Interventional2019-09-30Not yet recruiting
Hygiene Protocols for Cleaning Complete Dentures[NCT01906242]40 participants (Actual)Interventional2013-04-30Completed
Assessing the Impact of Bleach Baths on Itch, Cutaneous Inflammation, Microbial Flora and Skin Barrier Function in Adult Atopic Dermatitis Subjects[NCT01996150]58 participants (Actual)Interventional2014-01-31Completed
Post Operative Pain and Expression of Substance P, IL8 After the Use of Ketorolac Irrigant Following Single Visit Root Canal Treatment[NCT04319549]44 participants (Anticipated)Interventional2020-08-01Not yet recruiting
The Influence of Epigallocatechin Gallate (EGCG) as a Flushing Agent During Full Pulpotomy Using Two Different Calcium Silicate-based Materials on Postoperative Pain and Success Rate in Mature Permanent Molars With Irreversible Pulpitis: A Randomized Clin[NCT05811403]64 participants (Anticipated)Interventional2023-07-01Recruiting
Mouth Rinses Efficacy on Salivary SARS-CoV-2 Viral Load: A Randomized Clinical Trial[NCT04721457]Phase 490 participants (Actual)Interventional2021-01-03Completed
The Effectiveness of Hyperpure Chlorine Dioxide and Sodium Hypochlorite Irrigants During Endodontic Retreament on the Healing of Chronic Periapical Lesions - Clinical, Radiological and Microbiological Study. Randomized Clinical Trial.[NCT04954638]40 participants (Anticipated)Observational2019-11-15Enrolling by invitation
Pakistan Flocculent Health Outcome Study[NCT01538953]8,949 participants (Actual)Interventional2003-03-31Completed
Estimation of the Incidence of Colonization of Peripheral Venous Catheters After Skin Disinfection With 0.5% Sodium Hypochlorite, Preceded or Not by an Application of 70% Ethanol: Pilot, Monocentric, Randomized, Open-label Study[NCT04391660]Phase 4240 participants (Actual)Interventional2020-06-15Completed
Application Success of Photodynamic Therapy and Diode Laser During Endodontic Therapy of Young Permanent Teeth[NCT03074136]Phase 245 participants (Actual)Interventional2017-02-10Completed
Clinical and Radiographic Evaluation of Diode and Er:Cr;YSGG Lasers as an Alternative to Formocresol and Sodium Hypochlorite for Pulpotomy Technique in Primary Molars - Randomized Controlled Clinical Trial[NCT06002646]Phase 460 participants (Actual)Interventional2023-01-04Active, not recruiting
Assessment of Postoperative Pain and Antibacterial Efficacy After Root Canal Irrigation With Curcumin Versus Sodium Hypochlorite in Patients With Necrotic Mandibular Molars: Randomized Clinical Trial[NCT04728386]38 participants (Anticipated)Interventional2021-01-31Not yet recruiting
Comparative Evaluation of Clinical and Radiographic Outcome by Using Three Different Irrigants, Sodium Hypochlorite (NaOCl), Chlorhexidine (CHX) and Combination of CHX+H2O2 in Primary Endodontic Treatment[NCT04373018]90 participants (Anticipated)Interventional2019-12-01Recruiting
Effect of Vachellia Nilotica Versus Sodium Hypochlorite as Root Canal Irrigant on Postoperative Pain and Bacterial Load Reduction in Mandibular Premolar Teeth With Necrotic Pulp[NCT06116214]Phase 446 participants (Anticipated)Interventional2023-11-30Not yet recruiting
Trial of Drain Antisepsis After Tissue Expander Breast Reconstruction[NCT01286168]Phase 2110 participants (Actual)Interventional2011-05-31Completed
A Randomized Study of Topical Dilute Hypochlorite (Modified Dakin's Solution) Treatment for the Prevention of Radiation Dermatitis in Head and Neck Cancer[NCT02369835]Phase 3132 participants (Actual)Interventional2015-05-31Completed
Effect of Sodium Hypochlorite Pre-treatment on the Retention of Restorations for Non-carious Cervical Lesions: A Randomized Controlled Trial[NCT03086720]30 participants (Anticipated)Interventional2012-07-31Active, not recruiting
The Impact of Treating Staphylococcus Aureus Infection and Colonization on the Clinical Severity of Atopic Dermatitis[NCT00179959]Phase 431 participants (Actual)Interventional2005-09-30Completed
Role Of Wound Lavage in Direct Pulp Capping Of Permanent Teeth With Carious Exposure: A Randomized Controlled Trial[NCT05878249]140 participants (Anticipated)Interventional2022-11-01Active, not recruiting
Treatment of Chronic Periapical Periodontitis of Young Permanent Teeth by Means of Three Adjuvant Treatment Approaches: A Prospective Comparative Microbiological and Clinical Study[NCT05291195]40 participants (Actual)Interventional2018-02-01Completed
A Castor Bean Solution Reduces Complete Denture Biofilm[NCT01732744]50 participants (Actual)Interventional2008-03-31Completed
Pilot Study of Utilizing Topical Sodium Hypochlorite to Ameliorate or Reduce Radiation Dermatitis[NCT04630821]6 participants (Actual)Interventional2021-02-08Terminated(stopped due to Low participant accrual)
Effects of Treatments on the Microbiome in Healthy Volunteers and Patients With Atopic Dermatitis[NCT01631617]Phase 2130 participants (Anticipated)Interventional2012-09-18Recruiting
Clinical Effects of Adjunctive Local Sodium Hypochlorite Gel in Minimally Invasive Non Surgical Debridement (MINSD) of Periodontal Pockets. A 6-month Randomized Controlled Clinical Trial[NCT04399187]40 participants (Actual)Interventional2018-04-01Completed
Acess the Clinical Effect of Antimicrobial Photodynamic Therapy (aPDT) on Root Canal Disinfection[NCT02929927]40 participants (Anticipated)Interventional2016-03-31Recruiting
Denture Condition: Influence on Masticatory Performance, Volatile Sulfur Compounds and Presence of Biofilm[NCT01616355]15 participants (Actual)Interventional2011-08-31Completed
Effect of Epigallocatechin-3-Gallate Solution Versus Sodium Hypochlorite as a Root Canal Irrigant on Post-Operative Pain Intensity and Bacterial Load Reduction in Asymptomatic Necrotic Mandibular Premolars: A Randomized Clinical Trial[NCT05988788]42 participants (Anticipated)Interventional2023-10-31Not yet recruiting
Comparison of Antimicrobial Action of Sodium Hypochlorite and Polyhexamethylene Biguanide as Root Canal Irrigants in Patients Reporting With Non-vital Necrotic Pulp and Apical Periodontitis[NCT05306431]Phase 260 participants (Actual)Interventional2022-06-01Completed
Comparing the Dentin Conditioning Effect of Different Single and Combination Chelating Agents on Sealer Penetration and Dentin Erosion[NCT05778227]100 participants (Actual)Interventional2021-11-16Completed
Pilot Study to Investigate the Impact of Hypochlorite in the Prevention of Radiation Dermatitis[NCT02203565]Phase 220 participants (Actual)Interventional2014-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

TrialOutcome
NCT00179959 (1) [back to overview]Change in Eczema Area and Severity Index (EASI)Scores According to Location
NCT01286168 (8) [back to overview]Number of Subjects With Drain Bulb Fluid Bacterial Colonization at Approximately 1 Week
NCT01286168 (8) [back to overview]Number of Subjects With Drain Bulb Fluid Bacterial Colonization at Removal
NCT01286168 (8) [back to overview]Number of Subjects With Drain Tubing Colonization at Removal
NCT01286168 (8) [back to overview]Number of Subjects With Surgical Site Infection Within 1 Year
NCT01286168 (8) [back to overview]Number of Subjects With Surgical Site Infection Within 30 Days
NCT01286168 (8) [back to overview]Per Drain Analysis: Drain Bulb Fluid Colonization at Approximately 1 Week
NCT01286168 (8) [back to overview]Per Drain Analysis: Drain Bulb Fluid Colonization at Removal
NCT01286168 (8) [back to overview]Per Drain Analysis: Drain Tubing Colonization at Removal
NCT02203565 (1) [back to overview]Percent of Women Who Develop Grade 3 or 4 Radiation Dermatitis (as Defined by the Stanford Radiation Dermatitis Scoring System) During a Course of Radiation Therapy
NCT02369835 (1) [back to overview]Radiation Dermatitis

Change in Eczema Area and Severity Index (EASI)Scores According to Location

The proportion of affected body surface area (BSA) was estimated from 4 designated body regions(head/neck, upper limbs, trunk, and lower limbs),and the Physician's Assessment of Individual Signs was determined for each region by grading signs of AD on a 4-point scale. Both the proportion of affected BSA and the Physician's Assessment of Individual Signs score were used to calculate the EASI score,a validated composite score that ranges from 0 (clear) to 72 (very severe). (NCT00179959)
Timeframe: Baseline and 3 months

,
InterventionChange in EASI Score (Mean)
Exposed Sites: Head and NeckBath-Submerged Sites: Limbs and Trunk
Placebo-0.57-0.88
Treatment-1.06-4.94

[back to top]

Number of Subjects With Drain Bulb Fluid Bacterial Colonization at Approximately 1 Week

Bacterial growth was defined as plate growth of 1+ or greater. Drains were removed at variable times across patients, per clinical indication. When clinically indicated, some patients did have their drains removed at the one week visit, in which case they only had one bulb fluid culture. (NCT01286168)
Timeframe: Approximately 1 week after surgery

Interventionparticipants (Number)
Antisepsis SideControl Side
Entire Study Population1021

[back to top]

Number of Subjects With Drain Bulb Fluid Bacterial Colonization at Removal

Bacterial growth was defined as plate growth of 1+ or greater. Drains were removed a variable times across patients, per clinical indication. A second bulb culture was obtained later than 1 week ONLY in those drains that were not removed at 1 week. (NCT01286168)
Timeframe: Approximately 2 weeks after surgery

Interventionparticipants (Number)
Antisepsis SideControl Side
Entire Study Population1428

[back to top]

Number of Subjects With Drain Tubing Colonization at Removal

Drain tubing colonization was defined as greater than 50 colony forming units. Drains were removed at variable timepoints based on the clinical situation. (NCT01286168)
Timeframe: Approximately two weeks after surgery

Interventionparticipants (Number)
Antisepsis SideControl Side
Entire Study Population06

[back to top]

Number of Subjects With Surgical Site Infection Within 1 Year

(NCT01286168)
Timeframe: Approximately one year after surgery

Interventionparticipants (Number)
Antisepsis SideControl Side
Entire Study Population36

[back to top]

Number of Subjects With Surgical Site Infection Within 30 Days

(NCT01286168)
Timeframe: Approximately 30 days after surgery

Interventionparticipants (Number)
Antisepsis SideControl Side
Entire Study Population04

[back to top]

Per Drain Analysis: Drain Bulb Fluid Colonization at Approximately 1 Week

(NCT01286168)
Timeframe: Approximately 1 week after surgery

Interventiondrains (Number)
Antisepsis side n=157 drainsControl side n=160 drains
Entire Study Population1125

[back to top]

Per Drain Analysis: Drain Bulb Fluid Colonization at Removal

(NCT01286168)
Timeframe: Approximately one month after surgery

Interventiondrains (Number)
Antisepsis side, n=85 drainsControl side, n=88 drains
Entire Study Population1433

[back to top]

Per Drain Analysis: Drain Tubing Colonization at Removal

(NCT01286168)
Timeframe: Approximately one month after surgery

Interventiondrains (Number)
Antisepsis side, n=151 drainsControl side, n=154
Entire Study Population06

[back to top]

Percent of Women Who Develop Grade 3 or 4 Radiation Dermatitis (as Defined by the Stanford Radiation Dermatitis Scoring System) During a Course of Radiation Therapy

"Stanford Radiation Dermatitis Scoring System:~Grade Clinical finding~0 No skin change~1 Faint, barely detectable erythema 2 Follicular rash, hyperpigmentation, evolving erythema 3 Dry desquamation, brisk erythema 4 Moist desquamation 5 Bleeding, ulceration, and/or infection" (NCT02203565)
Timeframe: Baseline to up to 6 weeks after completion of therapy

InterventionParticipants (Count of Participants)
Supportive Care (Dakin's Solution, Radiation Therapy)6

[back to top]

Radiation Dermatitis

"Participants were assessed for radiation dermatitis on the arms according to the Stanford Radiation Dermatitis Scoring System (SRDSS), at baseline and through their treatment course. The outcome is reported by treatment group as the number and proportion of participants that experience SRDSS Grade E or greater radiation dermatitis through 10 weeks after completion of radiation treatment, a number without dispersion.~SRDSS, by grade:~A. No skin change~B. Faint, barely detectable erythema~C. Follicular rash, hyperpigmentation, evolving erythema~D. Dry desquamation, brisk erythema~E. Moist desquamation~F. Bleeding, ulceration, and/or infection~SRDSS Grade E is roughly equivalent to the Common Terminology Criteria for Adverse Events (CTCAE) Version 4.03 Grade 3 radiation dermatitis, Moist desquamation in areas other than skin folds and creases; bleeding induced by minor trauma or abrasion" (NCT02369835)
Timeframe: From first radiation treatment up to 10 weeks after completion of radiation treatment. Because much of the study data was not provided by the prior investigator to the current Responsible Party, it is not possible to be more precise than stated.

InterventionParticipants (Count of Participants)
Arm I (Modified Dakin's Solution)34
Arm II (Placebo)36

[back to top]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
phenytoin
[no description available]		8.411imidazolidine-2,4-dioneanticonvulsant;
drug allergen;
sodium channel blocker;
teratogenic agent
gentamicin
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.		2.610
metronidazole
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.. metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.		3.7621C-nitro compound;
imidazoles;
primary alcohol		antiamoebic agent;
antibacterial drug;
antimicrobial agent;
antiparasitic agent;
antitrichomonal drug;
environmental contaminant;
prodrug;
radiosensitizing agent;
xenobiotic
thiram
Thiram: A dithiocarbamate chemical, used commercially in the rubber processing industry and as a fungicide. In vivo studies indicate that it inactivates the enzyme GLUTATHIONE REDUCTASE. It has mutagenic activity and may induce chromosomal aberrations.. thiram : An organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid. It is widely used as a fungicidal seed treatment.		1.9210organic disulfideantibacterial drug;
antifungal agrochemical;
antiseptic drug
triclosan
[no description available]		1.9710aromatic ether;
dichlorobenzene;
monochlorobenzenes;
phenols		antibacterial agent;
antimalarial;
drug allergen;
EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
fungicide;
persistent organic pollutant;
xenobiotic
sucrose
Saccharum: A plant genus of the family POACEAE widely cultivated in the tropics for the sweet cane that is processed into sugar.		1.9710glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
benzoyl peroxide
Benzoyl Peroxide: A peroxide derivative that has been used topically for BURNS and as a dermatologic agent in the treatment of ACNE and POISON IVY DERMATITIS. It is used also as a bleach in the food industry.		8.3411carbonyl compound
zinc oxide
Zinc Oxide: A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.		3.3411zinc molecular entity
calcium hypochlorite
calcium hypochlorite: structure		2.0110calcium salt;
inorganic calcium salt		bleaching agent
chloramine
[no description available]		6.9210halide
delphinidin
Paraffin: A mixture of solid hydrocarbons obtained from petroleum. It has a wide range of uses including as a stiffening agent in ointments, as a lubricant, and as a topical anti-inflammatory. It is also commonly used as an embedding material in histology.. delphinidin chloride : An anthocyanidin chloride that has delphinidin as the cationic counterpart.		3.7521anthocyanidin chloride
benzoic acid, malic acid, propylene glycol, salicylic acid drug combination
[no description available]		2.6830
povidone-iodine
Povidone-Iodine: An iodinated polyvinyl polymer used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol. The iodine may be radiolabeled for research purposes.		3.7830
chlorhexidine
Chlorhexidine: A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.. chlorhexidine : A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge.		1.9710biguanides;
monochlorobenzenes		antibacterial agent;
antiinfective agent
sodium hypochlorite
Sodium Hypochlorite: It is used as an oxidizing and bleaching agent and as a disinfectant. (From Grant & Hackh's Chemical Dictionary, 5th ed). sodium hypochlorite : An inorganic sodium salt in which hypochlorite is the counterion. It is used as a bleaching and disinfecting agent and is commonly found in household bleach.		10.28409inorganic sodium saltbleaching agent;
disinfectant
salicylates
Salicylates: The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.. hydroxybenzoate : Any benzoate derivative carrying a single carboxylate group and at least one hydroxy substituent.. salicylates : Any salt or ester arising from reaction of the carboxy group of salicylic acid, or any ester resulting from the condensation of the phenolic hydroxy group of salicylic acid with an organic acid.. salicylate : A monohydroxybenzoate that is the conjugate base of salicylic acid.		2.6830monohydroxybenzoateplant metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Stasis Ulcer
[description not available]		04.721
Varicose Ulcer
Skin breakdown or ulceration in the drainage area of a VARICOSE VEIN, usually in the leg.		04.721
Infection, Postoperative Wound
[description not available]		02.1310
Injuries
Used with anatomic headings, animals, and sports for wounds and injuries. Excludes cell damage, for which pathology is used.		05.6771
Wounds and Injuries
Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.		05.6771
Necrosis
The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.		02.9210
Allergic Contact Dermatitis
[description not available]		02.0110
Acroosteolysis, Giaccai Type
[description not available]		02.0110
Foot Ulcer
Lesion on the surface of the skin of the foot, usually accompanied by inflammation. The lesion may become infected or necrotic and is frequently associated with diabetes or leprosy.		02.0110
Foot Dermatoses
Skin diseases of the foot, general or unspecified.		02.0110
Hereditary Sensory and Autonomic Neuropathies
A group of inherited disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and clinically by loss of sensation and autonomic dysfunction. There are five subtypes. Type I features autosomal dominant inheritance and distal sensory involvement. Type II is characterized by autosomal inheritance and distal and proximal sensory loss. Type III is DYSAUTONOMIA, FAMILIAL. Type IV features insensitivity to pain, heat intolerance, and mental deficiency. Type V is characterized by a selective loss of pain with intact light touch and vibratory sensation. (From Joynt, Clinical Neurology, 1995, Ch51, pp142-4)		02.0110
Dermatitis, Allergic Contact
A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.		02.0110
Chronic Illness
[description not available]		0533
Leg Ulcer
Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (VARICOSE ULCER), 5% to arterial disease, and the remaining 5% to other causes.		05.6554
Chronic Disease
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).		0533
HbS Disease
[description not available]		04.6332
Anemia, Sickle Cell
A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.		04.6332
Infections, Chlamydia
[description not available]		02.0210
Ache
[description not available]		02.0210
Chlamydia Infections
Infections with bacteria of the genus CHLAMYDIA.		02.0210
Pain
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.		02.0210
Abscess
Accumulation of purulent material in tissues, organs, or circumscribed spaces, usually associated with signs of infection.		09.3422
Bed Sores
[description not available]		04.4651
Pressure Ulcer
An ulceration caused by prolonged pressure on the SKIN and TISSUES when one stays in one position for a long period of time, such as lying in bed. The bony areas of the body are the most frequently affected sites which become ischemic (ISCHEMIA) under sustained and constant pressure.		04.4651
Foot Diseases
Anatomical and functional disorders affecting the foot.		03.3411
Hansen Disease
[description not available]		03.3411
Leprosy
A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.		03.3411
Ulcer
A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.		03.7621
Gangrene
Death and putrefaction of tissue usually due to a loss of blood supply.		01.9610
Genital Diseases, Male
Pathological processes involving the male reproductive tract (GENITALIA, MALE).		01.9610
Symptom Cluster
[description not available]		01.9610
Syndrome
A characteristic symptom complex.		01.9610
Infection, Wound
[description not available]		03.0850
Burns
Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.		02.940
Carcinoma, Epidermoid
[description not available]		02.9110
Neoplasms, Skull
[description not available]		02.9110
Carcinoma, Squamous Cell
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)		02.9110
Injuries, Leg
[description not available]		01.9810
Empyema, Thoracic
[description not available]		01.9810
Empyema, Pleural
Suppurative inflammation of the pleural space.		01.9810
Contact Dermatitis
[description not available]		01.9810
Dermatitis, Contact
A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.		01.9810
Pilonidal Cyst
[description not available]		03.3611
Pilonidal Sinus
A hair-containing cyst or sinus, occurring chiefly in the coccygeal region.		08.3611
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		01.9710
Complication, Postoperative
[description not available]		01.9610
Postoperative Complications
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.		01.9610