Resveratrol is a naturally occurring polyphenol found in the skin of grapes, berries, peanuts, and other plants. It is known for its antioxidant and anti-inflammatory properties. Research suggests that resveratrol may offer a range of health benefits, including protection against heart disease, cancer, and neurodegenerative diseases. Its synthesis occurs in plants as a defense mechanism against environmental stressors such as UV radiation and fungal infections. Resveratrol activates the SIRT1 gene, which is involved in longevity and metabolic regulation. Its ability to mimic calorie restriction, a dietary intervention known to extend lifespan, has made it a target for studies investigating aging and age-related diseases. Extensive research is ongoing to explore the potential therapeutic applications of resveratrol in various conditions, including diabetes, Alzheimer's disease, and obesity. While promising, further research is needed to fully understand its long-term effects and optimal dosage.'
trans-resveratrol : A resveratrol in which the double bond has E configuration. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 445154 |
| CHEMBL ID | 165 |
| CHEBI ID | 27881 |
| CHEBI ID | 45713 |
| SCHEMBL ID | 19425 |
| MeSH ID | M0165532 |
| PubMed CID | 5056 |
| CHEMBL ID | 2019155 |
| Synonym |
|---|
| MLS001076538 |
| BRD-K25591257-001-01-2 |
| BRD-K80738081-001-06-2 |
| 5-[2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol |
| CHEBI:27881 , |
| MLS000069735 , |
| smr000058206 |
| srt-501 |
| resvida |
| rm-1812 |
| SDCCGMLS-0002998.P003 |
| c14h12o3 |
| nsc 327430 |
| nsc-327430 |
| nsc327430 |
| SGCUT00007 |
| EU-0101111 |
| inchi=1/c14h12o3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17h/b2-1 |
| resveratrol, >=99% (hplc) |
| PRESTWICK3_000508 |
| PRESTWICK2_000508 |
| BPBIO1_000479 |
| PRESTWICK_619 |
| BSPBIO_001114 |
| NCGC00024003-11 |
| resveratol |
| 5-[(e)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol |
| srt 501 |
| cid_445154 |
| bdbm23926 |
| srt501 |
| chembl165 , |
| stilbene, 2f |
| 3,4',5-stilbenetriol |
| 3,5,4'-trihydroxystilbene |
| 3,5,4'-trihydroxy-trans-stilbene |
| 1,3-benzenediol, 5-(2-(4-hydroxyphenyl)ethenyl)-, (e)- |
| (e)-5-[2-(4-hydroxyphenyl)ethenyl]-1,3-benzendiol |
| 5-[(e)-2-(4-hydroxyphenyl)vinyl]benzene-1,3-diol |
| BSPBIO_000435 |
| IDI1_002152 |
| LOPAC0_001111 |
| NCGC00024003-04 |
| trans-resveratrol |
| resveratrol , |
| 3,4',5-trihydroxystilbene |
| C03582 |
| 501-36-0 |
| TO_000079 |
| 3,4',5-trihydroxy-trans-stilbene |
| CHEBI:45713 , |
| DB02709 |
| (e)-resveratrol |
| (e)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol(e)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol |
| CU-01000001503-3 , |
| NCGC00024003-07 |
| NCGC00024003-08 |
| NCGC00024003-00 |
| NCGC00024003-06 |
| SPECTRUM1502223 |
| SPECTRUM5_000552 |
| BSPBIO_003461 |
| NCGC00024003-05 |
| NCGC00024003-10 |
| NCGC00024003-09 |
| MLS001055357 |
| LMPK13090005 |
| NCGC00017352-07 |
| R 5010 , |
| HMS2052I09 |
| 533C1DA0-4104-42B5-9D32-9265F40857E4 |
| 5-[(1e)-2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol |
| AC-727 |
| HMS1990H15 |
| resveratrol, e- |
| KUC104385N , |
| ksc-10-164 |
| NCGC00017352-17 |
| MLS002207121 |
| srt 501m |
| ca 1201 |
| resveratrol(e)-form |
| cuspidatin |
| (e)-5-(p-hydroxystyryl)resorcinol |
| bia 6-512 |
| resveratrol p 5 |
| bia-6-512 |
| biofort |
| melinjo resveratrol 20 |
| MLS002222231 |
| HMS1792H15 |
| HMS1362H15 |
| BRD-K80738081-001-10-4 |
| R0071 |
| trans-1,2-(3,4',5-trihydroxydiphenyl)ethylene |
| HMS1921N04 |
| HMS1569F17 |
| BRD-K80738081-001-09-6 |
| NCGC00024003-14 |
| NCGC00024003-12 |
| NCGC00024003-13 |
| HMS2096F17 |
| HMS3263O04 |
| trans-3,4',5-trihydroxystilbene |
| AKOS005720936 |
| q369o8926l , |
| ccris 8952 |
| hsdb 7571 |
| 5-((1e)-2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol |
| unii-q369o8926l |
| dtxcid2011980 |
| tox21_303376 |
| dtxsid4031980 , |
| NCGC00257465-01 |
| NCGC00258925-01 |
| tox21_201374 |
| A827984 |
| MLS001424228 |
| tox21_110257 |
| 133294-37-8 |
| HMS2232A18 |
| BRD-K80738081-001-23-7 |
| CCG-38874 |
| NCGC00017352-08 |
| NCGC00017352-09 |
| NCGC00017352-14 |
| NCGC00017352-06 |
| NCGC00017352-13 |
| NCGC00017352-15 |
| NCGC00017352-05 |
| NCGC00017352-18 |
| NCGC00017352-19 |
| NCGC00017352-16 |
| NCGC00017352-12 |
| NCGC00017352-11 |
| NCGC00017352-10 |
| (e)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol |
| 3,4',5-trihydroxy-stilbene |
| (e)-5-(4-hydroxystyryl)benzene-1,3-diol , |
| HY-16561 |
| CS-1050 |
| STL146386 |
| BCPP000091 |
| LP01111 |
| REGID_FOR_CID_6240 |
| 5-((e)-2-(4-hydroxyphenyl)-ethenyl) benzene-1,3 diol |
| resveratrol [hsdb] |
| resveratrol [vandf] |
| trans-resveratrol [usp-rs] |
| resveratrol [who-dd] |
| resveratrol [inci] |
| resveratrol [mi] |
| resveratrol [mart.] |
| S1396 |
| N88795 |
| AB00052942-29 |
| gtpl8741 |
| NC00349 |
| REGID_FOR_CID_445154 |
| BBL028252 |
| SCHEMBL19425 |
| 3FTS |
| tox21_110257_1 |
| NCGC00017352-24 |
| 2L98 |
| KS-5047 |
| (e)1-(3,5-dihydroxyphenyl)-2-(4-hydroxyphenyl)ethene |
| 5[(e)-2-(4-hydroxyphenyl)-vinyl]benzene 1,3-diol |
| (e)-1-(3,5-dihydroxyphenyl)-2-(4-hydroxyphenyl)ethene |
| tox21_501111 |
| NCGC00261796-01 |
| mfcd00133799 |
| 5-[(1e)-2-(4-hydroxyphenyl)ethenyl]-1,3,benzenediol |
| 5-[(e)-2-(4-hydroxyphenyl)ethenyl]benzol-1,3-diol |
| 5-[(e)-2-(4-hydroxyphenyl)vinyl]-1,3-benzenediol |
| 5-[(e)-2-(4-hydroxyphenyl)vinyl]-1,3-benzoldiol |
| resveratrol, trans- |
| 5-[2-(4-hydroxyphenyl)vinyl]-1,3-benzenediol |
| trans-3,4',5 - trihydroxystilbene |
| 1,3-benzenediol, 5-[(e)-2-(4-hydroxyphenyl)ethenyl]- |
| 1,3-benzenediol, 5-[(1e)-2-(4-hydroxyphenyl)ethenyl]- |
| 1,3-benzenediol, 5-[(1z)-2-(4-hydroxyphenyl)ethenyl]- |
| trans-resveratrol, united states pharmacopeia (usp) reference standard |
| HB4055 |
| HMS3403H15 |
| HMS3649A20 |
| AB00052942_31 |
| OPERA_ID_586 |
| 4JAZ |
| 4QER |
| resveratrol, certified reference material, tracecert(r) |
| resveratrol, analytical standard |
| resveratrol, vetec(tm) reagent grade, 98% |
| resveratrol, european pharmacopoeia (ep) reference standard |
| SR-01000000163-11 |
| SR-01000000163-10 |
| SR-01000000163-3 |
| SR-01000000163-9 |
| sr-01000000163 |
| SR-01000000163-4 |
| SW196786-4 |
| Q407329 |
| HMS3676O14 |
| resveratrol,(s) |
| 31100-06-8 |
| trans-resveratrol 100 microg/ml in acetonitrile |
| AS-12413 |
| SR-01000000163-16 |
| BCP01416 |
| taxuschinensisirehd |
| HMS3412O14 |
| BRD-K80738081-001-07-0 |
| SDCCGSBI-0051080.P003 |
| NCGC00017352-39 |
| AMY5760 |
| trans resveratrol |
| 1,3-benzenediol, 5-((e)-2-(4-hydroxyphenyl)ethenyl)- |
| trans [2,5,4'-trihydroxydiphenyl] ethylene |
| NCGC00017352-31 |
| resveratrol (standard) |
| HY-16561R |
| CS-0694771 |
| resveratrol (mart.) |
| 5-((e)-2-(4-hydroxyphenyl)vinyl)benzene-1,3-diol |
| 1,3-benzenediol, 5-(2-(4-hydroxyphenyl)-ethenyl)-, (e)- |
| 5-(2-(4-hydroxyphenyl)ethenyl)benzene-1,3-diol |
| trans-resveratrol (usp-rs) |
| 5-((1e)-2-(4-hydroxyphenyl)ethenyl)benzene-1,3-diol |
| HMS3267J06 |
| HMS3394I09 |
| DIVK1C_006487 |
| KBIO1_001431 |
| NCI60_002840 |
| SPECTRUM4_001896 |
| SPECTRUM_001148 |
| BIO2_000877 |
| BIO2_000397 |
| SMP1_000257 |
| OPREA1_727238 |
| KBIO2_000454 |
| KBIO2_003022 |
| KBIO3_002965 |
| KBIOSS_001628 |
| KBIO2_004196 |
| KBIOGR_002457 |
| KBIOGR_000454 |
| KBIO2_001628 |
| MOLMAP_000045 |
| KBIO2_005590 |
| KBIO2_006764 |
| KBIOSS_000454 |
| KBIO3_000847 |
| KBIO3_000848 |
| PRESTWICK1_000508 |
| SPECPLUS_000391 |
| PRESTWICK0_000508 |
| SPECTRUM2_001497 |
| SPECTRUM3_001821 |
| SPBIO_002356 |
| SPBIO_001513 |
| FT-0654236 |
| 1,3-benzenediol, 5-[2-(4-hydroxyphenyl)ethenyl]- |
| CHEMBL2019155 |
| (cis-trans)-resveratrol |
| FT-0603427 |
| NCGC00017352-23 |
| LUKBXSAWLPMMSZ-UHFFFAOYSA-N |
| 5-[2-(4-hydroxyphenyl)vinyl]benzene-1,3-diol |
| AKOS025244084 |
| SY014849 |
| HMS3654D04 |
| (resveratrol) |
| DTXSID10859420 |
| Q60998680 |
| SB17273 |
| HMS3426I09 |
| HMS3871F03 |
Resveratrol and silymarin reduced tBH-induced hepatocyte toxic effects in short term experiments (5h) as measured by a significant reduction in ALT and NO increase. Taken together, the present data indicate that resver atrol is toxic to cultured macrophages, T cells and skin cells at concentrations>or=25 micromol L(-1)
The rate of absorption of trans-resveratrol following an oral 400 mg single-dose was significantly delayed by the presence of food, as reflected by Cmax and tmax. TMS had greater plasma exposure, longer elimination half-life and lower clearance.
A new monofunctional planaramineplatinum(II) complex, namely tris(8-hydroxyquinoline)monochloroplatinum( II) chloride (coded as LH3), was synthesised. It was investigated for its activity against human ovarian A2780, cisplatin-resistant A27 80 (A2780(cisR)) and ZD0473-resistant cancer cell lines. The complex could be used in combination with curcumin, genistein and resveratrol.
| Excerpt | Reference | Relevance |
|---|---|---|
| " Similar antiviral activity was demonstrated when ddI was combined with 5 or 10 mM RV in PBMCs infected with clinical isolates of HIV-1." | ( Synergistic inhibition of HIV-1 in activated and resting peripheral blood mononuclear cells, monocyte-derived macrophages, and selected drug-resistant isolates with nucleoside analogues combined with a natural product, resveratrol. Davis, C; Heredia, A; Redfield, R, 2000) | 0.31 |
| "To investigate the effect of resveratrol (Res) alone and its combination with cyclosporin A (CsA) on the proliferation of human peripheral blood T lymphocytes (hPBTCs), transformation into lymphoblasts, as well as IL-2 and INF-gamma production." | ( [Effect of resveratrol alone and its combination with cyclosporin A on the immune function of human peripheral blood T lymphocytes]. Pan, CE; Wu, SL; Yu, L; Zhang, M, 2003) | 0.32 |
| " Resveratrol partially reversed the inhibitory effects of low concentrations of LPS alone, and completely reversed the inhibition of nodule formation when low concentrations of LPS were combined with BaP." | ( Inhibition of osteogenesis in vitro by a cigarette smoke-associated hydrocarbon combined with Porphyromonas gingivalis lipopolysaccharide: reversal by resveratrol. Andreou, V; Casper, RF; D'Addario, M; Ellen, RP; Sukhu, B; Tenenbaum, HC; Zohar, R, 2004) | 0.32 |
| "To study the anti-tumor effect of resveratrol and in combination with 5-FU on murine liver cancer." | ( Effect of resveratrol and in combination with 5-FU on murine liver cancer. Meng, KW; Pan, CE; Qin, XL; Sun, ZJ; Wu, SL; Yu, L, 2004) | 0.32 |
| "Transplantable murine hepatoma22 model was used to evaluate the anti-tumor activity of resveratrol (RES) alone or in combination with 5-FU in vivo." | ( Effect of resveratrol and in combination with 5-FU on murine liver cancer. Meng, KW; Pan, CE; Qin, XL; Sun, ZJ; Wu, SL; Yu, L, 2004) | 0.32 |
| " The enhanced inhibition of tumor growth by 5-FU was also observed in hepatoma22 bearing mice when 5-FU was administered in combination with 10 mg/kg resveratrol." | ( Effect of resveratrol and in combination with 5-FU on murine liver cancer. Meng, KW; Pan, CE; Qin, XL; Sun, ZJ; Wu, SL; Yu, L, 2004) | 0.32 |
| " Nowadays, using artificial neural networks (ANN's) in combination with MVA is rapidly expanding." | ( Optimization of solid-phase extraction using artificial neural networks in combination with experimental design for determination of resveratrol by capillary zone electrophoresis in wines. Farková, M; Havel, J; Pazourek, J; Spanilá, M, 2005) | 0.33 |
| " We studied the effects of methyl jasmonate in combination with sucrose on defense-related gene expression, stilbene and anthocyanin production in grapevine cell suspensions." | ( Effect of methyl jasmonate in combination with carbohydrates on gene expression of PR proteins, stilbene and anthocyanin accumulation in grapevine cell cultures. Barrieu, F; Belhadj, A; Cluzet, S; Hamdi, S; Mérillon, JM; Saigne, C; Telef, N, 2008) | 0.35 |
| "To explore the effects of garlic oil combined with resveratrol on the apoptosis and expression of Fas, bcl-2 and bax in human gastric cancer cell line MGC-803." | ( [Effects of garlic oil combined with resveratrol on inducting of apoptosis and expression of Fas, bcl-2 and bax in human gastric cancer cell line]. Li, HQ; Zheng, GH, 2008) | 0.35 |
| "The garlic oil combined with resveratrol induced cell apoptosis markedly at the 24th after the treatment The protein expression of Fas in the combined medicine groups was 10." | ( [Effects of garlic oil combined with resveratrol on inducting of apoptosis and expression of Fas, bcl-2 and bax in human gastric cancer cell line]. Li, HQ; Zheng, GH, 2008) | 0.35 |
| "The garlic oil combined with the resveratrol might obviously induce the apoptosis of gastric cancer cell line MGC-803 which be involved in increasing the expression of Fas protein and bax gene and decreasing the expression of bcl-2 gene at the same time." | ( [Effects of garlic oil combined with resveratrol on inducting of apoptosis and expression of Fas, bcl-2 and bax in human gastric cancer cell line]. Li, HQ; Zheng, GH, 2008) | 0.35 |
| " In the next step the action of RES alone or in combination with ROSC was examined." | ( Action of resveratrol alone or in combination with roscovitine, a CDK inhibitor, on cell cycle progression in human HL-60 leukemia cells. Komina, O; Wesierska-Gadek, J, 2008) | 0.35 |
| " In this study, the effect of infection with oncolytic H-1 parvovirus (H-1PV) combined with antibiotic norfloxacin (NFX) or phytoalexin resveratrol on the survival of cell lines Panc-1 and BxPC3 derived from human pancreatic carcinoma was tested." | ( Anticancer effects of an oncolytic parvovirus combined with non-conventional therapeutics on pancreatic carcinoma cell lines. Angelova, A; Galabov, AS; Georgieva, PB; Raykov, Z; Rommelaere, J, 2009) | 0.35 |
| "We investigated the anti-tumor effect of peritumoral resveratrol in combination with immunotherapy in vivo in neuroblastoma-bearing mice." | ( The anti-tumor effect of resveratrol alone or in combination with immunotherapy in a neuroblastoma model. Gillies, SD; Hank, JA; Kim, K; Polans, AS; Rakhmilevich, AL; Reisfeld, RA; Seo, S; Sondel, PM; Soto, BL; Subramanian, L; Van De Voort, TJ; Yang, RK, 2011) | 0.37 |
| " This study aimed at examining effects of resveratrol alone and in combination with curcumin or chrysin on UGT induction in Caco-2 cells." | ( Resveratrol in combination with other dietary polyphenols concomitantly enhances antiproliferation and UGT1A1 induction in Caco-2 cells. Iwuchukwu, OF; Nagar, S; Tallarida, RJ, 2011) | 0.37 |
| " In the present study, we investigated the effects of all-trans retinoic acid (ATRA), vitamin D₃ and resveratrol alone and in combination with adenosine analogues, 2-chloro-2'-deoxyadenosine (2CdA) and 9-β-d-arabinosyl-2-fluoroadenine (F-ara-A), on the methylation and expression of phosphatase and tensin homologue (PTEN) tumour suppressor gene in MCF-7 and MDA-MB-231 breast cancer cells." | ( Comparative effects of retinoic acid, vitamin D and resveratrol alone and in combination with adenosine analogues on methylation and expression of phosphatase and tensin homologue tumour suppressor gene in breast cancer cells. Bednarek, A; Fabianowska-Majewska, K; Salamé, P; Stefanska, B, 2012) | 0.38 |
| " Recent in vivo studies and clinical trials indicate a possible drug-drug interaction potential using high-dosage formulations." | ( Drug interaction potential of resveratrol. Beck, M; Detampel, P; Huwyler, J; Krähenbühl, S, 2012) | 0.38 |
| " The combination with cisplatin and etoposide resulted in a partially synergistic inhibition of cell proliferation." | ( The effect of resveratrol in combination with irradiation and chemotherapy: study using Merkel cell carcinoma cell lines. Bigenzahn, J; Brunner, M; Heiduschka, G; Houben, R; Lill, C; Schmid, R; Seemann, R; Thurnher, D, 2014) | 0.4 |
| "Due to its radiosensitizing effect, resveratrol seems to be a promising agent in combination with radiation therapy." | ( The effect of resveratrol in combination with irradiation and chemotherapy: study using Merkel cell carcinoma cell lines. Bigenzahn, J; Brunner, M; Heiduschka, G; Houben, R; Lill, C; Schmid, R; Seemann, R; Thurnher, D, 2014) | 0.4 |
| "To study the therapeutical effect and mechanisms of resveratrol and its combination with praziquantel on the liver fibrosis due to Schistosoma japonicum infection." | ( [Therapeutic effect of resveratrol as well as resveratrol combined with praziquantel on the liver fibrosis due to Schistosoma japonicum infection in mice]. Chen, Y; Xiao, Z, 2013) | 0.39 |
| " In this study, we explored whether short-term moderate CR (20%), either alone or in combination with resveratrol, can induce autophagy in the hearts of 26-month-old Fischer 344 × Brown Norway rats." | ( Calorie restriction combined with resveratrol induces autophagy and protects 26-month-old rat hearts from doxorubicin-induced toxicity. Dirain, ML; Dutta, D; Leeuwenburgh, C; Xu, J, 2014) | 0.4 |
| " Here, we show that diadenosine triphosphate, applied alone or in combination with cyclodextrins to the grapevine suspension-cultured cells, increased the transcript level of genes encoding key phenylpropanoid-pathway enzymes as well as the trans-resveratrol production inside cells and its secretion into the extracellular medium." | ( Diadenosine triphosphate is a novel factor which in combination with cyclodextrins synergistically enhances the biosynthesis of trans-resveratrol in Vitis vinifera cv. Monastrell suspension cultured cells. Belchí-Navarro, S; Czekała, Ł; Guranowski, A; Pedreño, MA; Pietrowska-Borek, M, 2014) | 0.4 |
| " In this study, a new monofunctional planaramineplatinum(II) complex, namely tris(8-hydroxyquinoline)monochloroplatinum(II) chloride (coded as LH3), was synthesised and investigated for its activity against human ovarian A2780, cisplatin-resistant A2780 (A2780(cisR)) and ZD0473-resistant A2780 (A2780(ZD0473R)) cancer cell lines, alone and in combination with the phytochemicals curcumin, genistein and resveratrol." | ( Synthesis of a monofunctional platinum compound and its activity alone and in combination with phytochemicals in ovarian tumor models. Arzuman, L; Beale, P; Huq, F; Proschogo, N; Yu, JQ, 2014) | 0.4 |
| "The aim of this study was to: (a) develop a simple, high performance thin layer chromatographic (HPTLC) method combined with direct 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay to rapidly assess and compare free radical scavenging activity or anti-oxidant activity for major classes of polyphenolics present in wines; and (b) to investigate relationship between free radical scavenging activity to the total polyphenolic content (TPC) and total antioxidant capacity (TAC) in the wine samples." | ( Development and validation of a simple high performance thin layer chromatography method combined with direct 1,1-diphenyl-2-picrylhydrazyl assay to quantify free radical scavenging activity in wine. Agatonovic-Kustrin, S; Morton, DW; Yusof, AP, 2016) | 0.43 |
| " The aim of this study is to investigate the synergistic anticancer effect of resveratrol in combination with cisplatin and the potential anticancer mechanisms involved in A549 cells." | ( The synergistic effect of resveratrol in combination with cisplatin on apoptosis via modulating autophagy in A549 cells. Hu, S; Kong, H; Li, X; Wang, H; Xie, W; Xu, R; Ye, L; Zeng, X, 2016) | 0.43 |
| "The potential of front-face fluorescence spectroscopy combined with second-order chemometric methods was investigated for the quantification of the main polyphenols present in wine samples." | ( Front-face fluorescence spectroscopy combined with second-order multivariate algorithms for the quantification of polyphenols in red wine samples. Cabrera-Bañegil, M; Durán-Merás, I; Galeano-Díaz, T; Hurtado-Sánchez, MD, 2017) | 0.46 |
| " But at present the effects of resveratrol combined with taxol on human laryngeal carcinoma cell strain Hep-2 and their underlying molecular mechanisms are rarely reported." | ( [Apoptosis mechanism of taxol combined with resveratrol on human laryngeal carcinoma Hep-2 cells]. Lu, CX; Sun, JH; Wu, CL, 2016) | 0.43 |
| " Resveratrol alone and its combination with glibenclamide decreased the arrhythmia score, the arrhythmic period and the incidence of other types of arrhythmias during the reperfusion period." | ( The protection of resveratrol and its combination with glibenclamide, but not berberine on the diabetic hearts against reperfusion-induced arrhythmias: the role of myocardial K Bozdogan, O; Eksioglu, D; Erim, F; Firat, T; Kaya, ST; Ozarslan, TO; Taskin, E; Yasar, S, 2019) | 0.51 |
| "To explore the preventive and therapeutic effects of Resveratrol combined with total flavones of hawthorn, compatibility of traditional Chinese medicines, on the endothelial cells injury after artery bypass graft surgery." | ( Resveratrol combined with total flavones of hawthorn alleviate the endothelial cells injury after coronary bypass graft surgery. Feng, B; He, S; Su, Z; Zheng, G; Zhu, Y, 2018) | 0.48 |
| " After CABG surgery, the rabbits were administrated with saline (model group), aspirin (Aspirin group), resveratrol (Res group), total flavones of hawthorn (Haw group) and resveratrol combined with total flavones of hawthorn (Res+Haw group) once a day for eight weeks, respectively." | ( Resveratrol combined with total flavones of hawthorn alleviate the endothelial cells injury after coronary bypass graft surgery. Feng, B; He, S; Su, Z; Zheng, G; Zhu, Y, 2018) | 0.48 |
| "Compared with the model group, the level of CECs density and the expressions of albumen and mRNA of ICAM-1 were significantly decreased in the aspirin,resveratrol,total flavones of hawthorn and resveratrol combined with total flavones of hawthorn groups (P < ." | ( Resveratrol combined with total flavones of hawthorn alleviate the endothelial cells injury after coronary bypass graft surgery. Feng, B; He, S; Su, Z; Zheng, G; Zhu, Y, 2018) | 0.48 |
| "The Resveratrol combined with total flavones of hawthorn could protect the endothelial cells after coronary artery bypass graft." | ( Resveratrol combined with total flavones of hawthorn alleviate the endothelial cells injury after coronary bypass graft surgery. Feng, B; He, S; Su, Z; Zheng, G; Zhu, Y, 2018) | 0.48 |
| "To investigate the effects of different intensity exercise combined with resveratrol on retinol binding protein 4(RBP4) mRNA and protein expression in visceral adipose tissue and plasma RBP4 concentration of aged obese rats." | ( [Effects of different intensities exercise combined with resveratrol on RBP4 in aged obese rats]. Bai, YP; Cui, JQ; Lin, C; Song, WW; Su, M; Wu, L; Zhang, HY, 2017) | 0.46 |
| "Different intensities exercise combined with resveratrol could reduce the RBP4 mRNA and protein expression in visceral adipose tissue and plasma RBP4 concentrations of aged obese rats, but less affected by exercise intensity." | ( [Effects of different intensities exercise combined with resveratrol on RBP4 in aged obese rats]. Bai, YP; Cui, JQ; Lin, C; Song, WW; Su, M; Wu, L; Zhang, HY, 2017) | 0.46 |
| " Initially, K562 cell culture experiments were performed using various bolus doses of resveratrol in combination with siRNA for 3 days using a factorial design of experiments approach." | ( Influence of controlled release of resveratrol from electrospun fibers in combination with siRNA on leukemia cells. Al-Attar, T; Madihally, SV, 2018) | 0.48 |
| " Resistance exercise in combination with resveratrol supplementation may be applied in the general population to achieve better physiological benefits, promote overall health, and promote participation in regular physical activities." | ( The Synergistic Effects of Resveratrol combined with Resistant Training on Exercise Performance and Physiological Adaption. Chiu, CC; Huang, CC; Huang, WC; Kan, NW; Lee, MC; Tung, YT, 2018) | 0.48 |
| " We speculate that treatment with human umbilical cord mesenchymal stem cells (hUCMSCs) combined with resveratrol can block this signaling pathway and protect podocyte function." | ( Protective effect of umbilical cord mesenchymal stem cells combined with resveratrol against renal podocyte damage in NOD mice. Cao, C; Guo, Y; Li, L; Lin, Y; Niu, J; Sun, Y; Wang, J; Wang, W; Wang, Y; Xian, Y, 2019) | 0.51 |
| "In the current in vitro study, we tried to examine the possible role of resveratrol as a sensitizer in combination with radiotherapy or hyperthermia." | ( Resveratrol Induces Apoptosis and Attenuates Proliferation of MCF-7 Cells in Combination with Radiation and Hyperthermia. Amini, P; Aryafar, T; Ashrafizadeh, M; Eftekhari, SM; Farhood, B; Khalafi, L; Mahdavi, SR; Musa, AE; Najafi, M; Nodooshan, SJ, 2021) | 0.62 |
| " This may indicate the sensitizing effect of resveratrol in combination with both radiotherapy and hyperthermia." | ( Resveratrol Induces Apoptosis and Attenuates Proliferation of MCF-7 Cells in Combination with Radiation and Hyperthermia. Amini, P; Aryafar, T; Ashrafizadeh, M; Eftekhari, SM; Farhood, B; Khalafi, L; Mahdavi, SR; Musa, AE; Najafi, M; Nodooshan, SJ, 2021) | 0.62 |
| "To investigate the effect of resveratrol(Res) combined with soy isoflavones(SIF) on apoptosisinduced by oxidative stress in hippocampus in aging model rats." | ( [Effects of resveratrol combined with soy isoflavones on apoptosis induced by oxidative stress in hippocampus of aging model rats]. Cheng, L; Li, X; Shi, M; Song, C; Zhang, L; Zhang, Y; Zhao, H, 2020) | 0.56 |
| "Sixty female SD rats were randomly divided into the Sham control group, aging model group, Res treatment group, SIF treatment group, Res combined with SIF treatment group and estrogen replacement therapy group(ERT group)." | ( [Effects of resveratrol combined with soy isoflavones on apoptosis induced by oxidative stress in hippocampus of aging model rats]. Cheng, L; Li, X; Shi, M; Song, C; Zhang, L; Zhang, Y; Zhao, H, 2020) | 0.56 |
| "A novel surface plasmon resonance-based P-gp ligand screening system (SPR-PLSS) combined with lentiviral particle (LVP) stabilization strategy was constructed to screen out potential P-gp inhibitors from natural products." | ( Surface plasmon resonance biosensor combined with lentiviral particle stabilization strategy for rapid and specific screening of P-Glycoprotein ligands. Cai, Y; Cao, Y; Chai, Y; Chen, L; Chen, X; Hong, Z; Liu, Y; Shi, Y; Wang, D; Zhu, Z, 2021) | 0.62 |
| "To explore the effect of resveratrol (RES) combined with donepezil hydrochloride on inflammatory factor level and cognitive function level of patients with Alzheimer's disease (AD)." | ( Effect of Resveratrol Combined with Donepezil Hydrochloride on Inflammatory Factor Level and Cognitive Function Level of Patients with Alzheimer's Disease. Fang, X; Wang, L; Zhang, J; Zhao, J, 2022) | 0.72 |
| " Here, we synthesized a new Res derivative ((E)-5-(dimethylamino)-2-(4-methoxystyryl)phenol), and attempted to determine the function of Res derivative combined with radial extracorporeal shock wave therapy (rESWT) in chronic nonbacterial prostatitis (CNP)." | ( Radial Extracorporeal Shock Wave Therapy Combined with Resveratrol Derivative Alleviates Chronic Nonbacterial Prostatitis in Rats. Bian, Z; Jin, C; Liang, C; Song, Z, 2023) | 0.91 |
| "This study aimed to investigate the mechanism of resveratrol(RES) combined with irinotecan(IRI) in the treatment of colorectal cancer(CRC)." | ( [Molecular mechanism of resveratrol combined with irinotecan in treatment of colorectal cancer]. Han, CL; Li, F; Li, KY; Liu, M; Shen, H; Wang, J; Wang, L; Yan, RY, 2023) | 0.91 |
The current studies entail successful formulation of systematically optimized (OPT) nanoparticulate drug delivery system to increase the oral bioavailability. These data suggest that oral resveratrol is attractive candidate as an agent capable of combating dioxin toxicity.
| Excerpt | Reference | Relevance |
|---|---|---|
| " Tissue concentrations showed a significant cardiac bioavailability and strong affinity for liver and kidneys." | ( Kinetics of trans- and cis-resveratrol (3,4',5-trihydroxystilbene) after red wine oral administration in rats. Bertelli, A; Bertelli, AA; Giovannini, L; Stradi, R; Tillement, JP; Urien, S, 1996) | 0.29 |
| "In view of the increasing interest in the biological activity of resveratrol, one of the components of red wine which is considered to be one of the main ingredients responsible for the beneficial effect of wine on human health, we have studied plasma kinetics and tissue bioavailability of this compound after red wine oral administration in rats." | ( Evaluation of kinetic parameters of natural phytoalexin in resveratrol orally administered in wine to rats. Bertelli, A; Bertelli, AA; Giovannini, L; Stradi, R; Tillement, JP; Urien, S, 1998) | 0.3 |
| " Despite its importance, little is known about its bioavailability in both humans and animals." | ( Determination of trans-resveratrol in plasma by HPLC. de la Torre-Boronat, MC; Juan, ME; Lamuela-Raventós, RM; Planas, JM, 1999) | 0.3 |
| " However, the bioavailability and metabolic pathways must be known before drawing any conclusions on the benefits of dietary resveratrol to health." | ( Biological effects of resveratrol. Frémont, L, 2000) | 0.31 |
| " It is present in the diet, and the hepatic and duodenal sulphation might limit the bioavailability of this compound." | ( Sulphation of resveratrol, a natural product present in grapes and wine, in the human liver and duodenum. De Santi, C; Mosca, F; Pacifici, GM; Pietrabissa, A; Spisni, R, 2000) | 0.31 |
| " Resveratrol is sulphated, and the hepatic and duodenal sulphation might limit the bioavailability of this compound." | ( Sulphation of resveratrol, a natural compound present in wine, and its inhibition by natural flavonoids. De Santi, C; Mosca, F; Pacifici, GM; Pietrabissa, A; Spisni, R, 2000) | 0.31 |
| " Glucuronidation may reduce the bioavailability of this compound however, flavonoids inhibit resveratrol glucuronidation and such an inhibition might improve the bioavailability of resveratrol." | ( Glucuronidation of resveratrol, a natural product present in grape and wine, in the human liver. de Santi, C; Mosca, F; Pacifici, GM; Pietrabissa, A, 2000) | 0.31 |
| " Urgent investigations on its bioavailability and effects on in vivo systems, especially in humans, are necessary." | ( Resveratrol, a natural chemopreventive agent against degenerative diseases. Baer-Dubowska, W; Ignatowicz, E, ) | 0.13 |
| " A time course study was also carried out to assess the bioavailability of resveratrol in serum, liver and brain using high performance liquid chromatography (HPLC)." | ( Resveratrol protects against global cerebral ischemic injury in gerbils. Lubahn, D; Rottinghaus, GE; Simonyi, A; Sun, AY; Sun, GY; Wang, Q; Xu, J, 2002) | 0.31 |
| " However, although it has numerous biological activities in vitro, there are few data about its bioavailability and tissue distribution in vivo." | ( Distribution of [14C]-trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration. Barthe, N; Brouillaud, B; Deffieux, G; Desmoulière, A; Krisa, S; Mérillon, JM; Rosenbaum, J; Vitrac, X, 2003) | 0.32 |
| " These results indicate that absorption of resveratrol in-vivo may be high but with limited bioavailability due to efficient sulfate conjugation." | ( Resveratrol transport and metabolism by human intestinal Caco-2 cells. Kaldas, MI; Walle, T; Walle, UK, 2003) | 0.32 |
| "The present study investigates the bioavailability of resveratrol and quercetin in humans, mice, and rats after oral ingestion of grape juice preparations or pure aglycones." | ( Urinary and plasma levels of resveratrol and quercetin in humans, mice, and rats after ingestion of pure compounds and grape juice. Lee, MJ; Lu, H; Maliakal, P; Meng, X; Yang, CS, 2004) | 0.32 |
| " Demonstration of its mechanism of action also implies the elucidation of the steps of bioavailability and bioabsorption in cells and tissues." | ( Transport of resveratrol, a cancer chemopreventive agent, to cellular targets: plasmatic protein binding and cell uptake. Berlot, JP; Delmas, D; Jannin, B; Lançon, A; Latruffe, N; Menzel, M, 2004) | 0.32 |
| " Although the systemic bioavailability of resveratrol is very low, accumulation of resveratrol in epithelial cells along the aerodigestive tract and potentially active resveratrol metabolites may still produce cancer-preventive and other effects." | ( High absorption but very low bioavailability of oral resveratrol in humans. DeLegge, MH; Hsieh, F; Oatis, JE; Walle, T; Walle, UK, 2004) | 0.32 |
| " Although the reported biological data indicate that resveratrol is a highly promising cardiovascular protective agent, more studies are needed to establish its bioavailability and in vivo cardioprotective effects, particularly in humans." | ( Cardiovascular protective effects of resveratrol. Barenghi, L; Bradamante, S; Villa, A, 2004) | 0.32 |
| " Currently, structural analogues of resveratrol with improved bioavailability are being pursued as potential therapeutic agents for cancer." | ( Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Aggarwal, BB; Aggarwal, RS; Bhardwaj, A; Seeram, NP; Shishodia, S; Takada, Y, ) | 0.13 |
| " The lack of effect on the chemopreventive parameters is probably due to the formation of various resveratrol conjugates reducing its bioavailability in the rat." | ( Bioactivity and metabolism of trans-resveratrol orally administered to Wistar rats. Erbersdobler, H; Soldo, T; Somoza, V; Wenzel, E, 2005) | 0.33 |
| " In order to reveal information on absorption, metabolism, and the consequent bioavailability of resveratrol, different research approaches were performed, including in vitro, ex vivo, and in vivo models, all of which are considered in this review." | ( Metabolism and bioavailability of trans-resveratrol. Somoza, V; Wenzel, E, 2005) | 0.33 |
| " Bioavailability studies mainly in animals or in humans using the pure compound at very high doses were performed." | ( Bioavailability of trans-resveratrol from red wine in humans. Caporaso, N; Fogliano, V; Galaverna, G; Ghidini, C; Marchelli, R; Sforza, S; Vescovi, PP; Vitaglione, P, 2005) | 0.33 |
| " It is worthy to note that the phenolic compound possesses a low bioavailability and rapid clearance from the plasma." | ( Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications. de la Lastra, CA; Villegas, I, 2005) | 0.33 |
| " Great differences emerge as far as ingested doses, bioavailability and liver ability to accumulate the various compounds." | ( Dietary antioxidant compounds and liver health. Caporaso, N; Fogliano, V; Morisco, F; Vitaglione, P, 2004) | 0.32 |
| " Critical areas of future investigation include: (1) identification of the direct molecular target(s) of EGCG and related polyphenolic compounds in cells; (2) the in vivo metabolism and bioavailability of these compounds; (3) the ancillary effects of these compounds on tumor-stromal interactions; (4) the development of synergistic combinations with other antitumor agents to enhance efficacy in cancer prevention and therapy, and also minimize potential toxicities." | ( Modulation of signal transduction by tea catechins and related phytochemicals. Shimizu, M; Weinstein, IB, 2005) | 0.33 |
| " Concordantly with data on bioavailability and metabolism of native resveratrol from the literature, these investigations revealed an extensive uptake and metabolism in the liver and kidney, respectively, of [(18)F]-1." | ( Synthesis and biodistribution of an 18F-labelled resveratrol derivative for small animal positron emission tomography. Bergmann, R; Gester, S; Pawelke, B; Pietzsch, J; Wuest, F, 2005) | 0.33 |
| " It would be important in the future to investigate the origins of the differences in wine stilbene levels in relation to the vine varieties, and the bioavailability of the newly extracted stilbene delta-viniferin in plasma after consumption of different types of wines." | ( Determination of stilbenes (delta-viniferin, trans-astringin, trans-piceid, cis- and trans-resveratrol, epsilon-viniferin) in Brazilian wines. Bornet, A; Delaunay, JC; Mérillon, JM; Richard, T; Teissédre, PL; Valls, J; Vanderlinde, R; Vitrac, X, 2005) | 0.33 |
| " BSDL is involved in the duodenal hydrolysis of lipid esters and in part of cholesteryl esters thus favoring the bioavailability of free cholesterol." | ( In vitro polyphenol effects on activity, expression and secretion of pancreatic bile salt-dependent lipase. Lombardo, D; Petit-Thévenin, JL; Ristorcelli, E; Sbarra, V; Teissedre, PL; Vérine, A, 2005) | 0.33 |
| " Since the bioavailability of ingested RS at distant organs is low and apoptosis induction often requires relatively high RS levels (above 20 micromol/l), this polyphenolic food ingredient might be particularly effective as a chemopreventive in the digestive tract." | ( Bax and Bak are the critical complementary effectors of colorectal cancer cell apoptosis by chemopreventive resveratrol. Mahyar-Roemer, M; Pöhland, T; Roemer, K; Wagner, S, 2006) | 0.33 |
| "Consumption of polyphenols is associated with health promotion through diet, although many are poorly absorbed in animals and humans alike." | ( Protection of lipids from oxidation by epicatechin, trans-resveratrol, and gallic and caffeic acids in intestinal model systems. Chetrit, D; Kerem, Z; Regev-Shoshani, G; Shoseyov, O, 2006) | 0.33 |
| " A number of points for consideration are raised: (1) the necessity to characterize wine analytically, as the content in important components of wine, such as resveratrol, is influenced considerably by regional factors, such as climate and local oenological procedures; (2) the bioavailability of the components of wine, which appears to be adequate as a broad range of biological effects have been documented at low concentrations that can be achieved by moderate chronic wine consumption; (3) the lack of importance of wine color, as also white wine consumption affords benefit, thanks to its content in the antioxidants caffeic acid, tyrosol and hydroxytyrosol, which are also found in olive oil; (4) the recommendation by WHO to "investigate the possible protective effects of ingredients other than alcohol in alcoholic beverages"." | ( Wine, research and cardiovascular disease: instructions for use. Bertelli, AA, 2007) | 0.34 |
| " Our results might provide a possible explanation for the in vivo antiplatelet effect of resveratrol despite the poor bioavailability and the weak in vitro activity." | ( Low concentrations of resveratrol potentiate the antiplatelet effect of prostaglandins. Wang, WY; Wu, CC; Wu, CI; Wu, YC, 2007) | 0.34 |
| " The absorption rate constants (ka) of Res-nanoliposomes in intestine were not significantly different." | ( [Study on drug release in vitro and rat intestinal absorption of resveratrol nanoliposomes]. Hou, SX; Li, W; Li, XY; Wang, XC; Zhou, YW, 2007) | 0.34 |
| " However, some of these agents have poor bioavailability and many of the in-depth studies into their mechanisms of action have been carried out in vitro using doses which are unachievable in humans." | ( Predicting the physiological relevance of in vitro cancer preventive activities of phytochemicals. Andreadi, CK; Foreman, BE; Howells, LM; Hudson, EA; Manson, MM; Moiseeva, EP; Neal, CP; Sun, YY, 2007) | 0.34 |
| " The bioavailability of the drug in serum was in the low micromolar range (2-10 micromol/L) and no accumulation was observed in tumor tissue." | ( Resveratrol inhibits tumor growth of human neuroblastoma and mediates apoptosis by directly targeting mitochondria. Albert, DM; Darjatmoko, SR; Kulkarni, A; Lindstrom, MJ; Polans, AS; Sareen, D; Subramanian, L; van Ginkel, PR; Walker, Q, 2007) | 0.34 |
| " In addition, the yeast-encapsulated resveratrol exhibited good stability, and its bioavailability was enhanced as a result of increased solubility of resveratrol and sustained releasing." | ( Stabilization and encapsulation of photosensitive resveratrol within yeast cell. Ji, R; Rao, L; Shi, G; Xiang, H; Yang, H; Yu, H, 2008) | 0.35 |
| " Being a phenolic compound, resveratrol certainly possesses a low bioavailability and most importantly, a rapid clearance from the plasma." | ( Anti-inflammatory responses of resveratrol. Das, DK; Das, S, 2007) | 0.34 |
| " In this report, we have reviewed the most recent scientific knowledge on the bioavailability and biological activity of these polyphenols ('fact'), as well as the health claims (which are not always supported by scientific studies) ascribed to the polyphenols-containing nutraceuticals ('fiction')." | ( Nutraceuticals: facts and fiction. Espín, JC; García-Conesa, MT; Tomás-Barberán, FA, ) | 0.13 |
| " Since oral administration resulted in relatively low bioavailability of resveratrol, the effect of increased local levels was tested by peritumor injection of the drug." | ( Resveratrol inhibits uveal melanoma tumor growth via early mitochondrial dysfunction. Albert, DM; Bhattacharya, S; Darjatmoko, SR; Lindstrom, MJ; Polans, AS; Sareen, D; Subramanian, L; van Ginkel, PR, 2008) | 0.35 |
| "These data suggest that resveratrol can inhibit tumor growth and can induce apoptosis via the intrinsic mitochondrial pathway and that by further increasing bioavailability of resveratrol the potency of the drug can be increased, leading to tumor regression." | ( Resveratrol inhibits uveal melanoma tumor growth via early mitochondrial dysfunction. Albert, DM; Bhattacharya, S; Darjatmoko, SR; Lindstrom, MJ; Polans, AS; Sareen, D; Subramanian, L; van Ginkel, PR, 2008) | 0.35 |
| " Pharmacokinetic evidence in rodents and humans suggests that the bioavailability of resveratrol is very low and that resveratrol conjugates are the major circulating agent-derived species." | ( Resveratrol from red grapes - pedestrian polyphenol or useful anticancer agent? Gescher, AJ, 2008) | 0.35 |
| " The bioavailability of orally administered resveratrol is insufficient to permit high enough drug concentrations for systemic therapy." | ( Delivery of resveratrol, a red wine polyphenol, from solutions and hydrogels via the skin. Fang, JY; Huang, ZR; Hung, CF; Lin, YK, 2008) | 0.35 |
| " The low bioavailability of this compound enhances its concentration in the luminal content and becomes a potential chemopreventive agent against colon cancer." | ( Resveratrol induces apoptosis through ROS-dependent mitochondria pathway in HT-29 human colorectal carcinoma cells. Daniel, H; Juan, ME; Planas, JM; Wenzel, U, 2008) | 0.35 |
| " RM-beta-CD significantly increased the maximal plasma concentration of orally administered resveratrol, but, it did not increase the oral bioavailability in comparison with the CMC suspension." | ( The impact of aqueous solubility and dose on the pharmacokinetic profiles of resveratrol. Das, S; Ho, PC; Lin, HS; Ng, KY, 2008) | 0.35 |
| " Further, dose manipulation (up to 50 mg kg(-1)) did not have a significant impact on the oral bioavailability of resveratrol." | ( The impact of aqueous solubility and dose on the pharmacokinetic profiles of resveratrol. Das, S; Ho, PC; Lin, HS; Ng, KY, 2008) | 0.35 |
| "Several in vitro studies have demonstrated the ability of pure trans-resveratrol (t-Res) to act as an anti-oxidant, but the scientific literature is lacking in in vivo studies dealing with dietary t-Res bioavailability in oxidative stress models." | ( Dietary trans-resveratrol bioavailability and effect on CCl4-induced liver lipid peroxidation. Caporaso, N; Fogliano, V; Milani, S; Morisco, F; Ottanelli, B; Vitaglione, P, 2009) | 0.35 |
| " Current topics of debate are their bioavailability and bioactivity." | ( Bioactivity and structure of biophenols as mediators of chronic diseases. Robards, K; Tucker, G, 2008) | 0.35 |
| " The objective of this study was to investigate the effect of food on the bioavailability of trans-resveratrol following oral administration." | ( Effect of food on the pharmacokinetic profile of trans-resveratrol. Almeida, L; Falcao, A; Fernandes-Lopes, C; Loureiro, AI; Nunes, T; Rocha, JF; Soares, E; Soares-da-Silva, P; Vaz-da-Silva, M; Wright, L, 2008) | 0.35 |
| "The rate of absorption of trans-resveratrol following an oral 400 mg single-dose was significantly delayed by the presence of food, as reflected by Cmax and tmax." | ( Effect of food on the pharmacokinetic profile of trans-resveratrol. Almeida, L; Falcao, A; Fernandes-Lopes, C; Loureiro, AI; Nunes, T; Rocha, JF; Soares, E; Soares-da-Silva, P; Vaz-da-Silva, M; Wright, L, 2008) | 0.35 |
| " Consequently, the absolute bioavailability (AB) of diltiazem in the presence of resveratrol (2." | ( Effects of resveratrol on the pharmacokinetics of diltiazem and its major metabolite, desacetyldiltiazem, in rats. Choi, DH; Choi, JS; Hong, SP, 2008) | 0.35 |
| " Despite scepticism concerning the bioavailability of these polyphenols, in vivo data have clearly demonstrated the neuroprotective properties of the naturally occurring polyphenol resveratrol in rodent models for stress and diseases." | ( Therapeutic potential of resveratrol in Alzheimer's disease. Davies, P; Dreses-Werringloer, U; Marambaud, P; Vingtdeux, V; Zhao, H, 2008) | 0.35 |
| " Bioavailability was higher after morning administration." | ( Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers. Almeida, L; Costa, R; Falcão, A; Fernandes-Lopes, C; Loureiro, AI; Nunes, T; Rocha, JF; Soares, E; Soares-da-Silva, P; Vaz-da-Silva, M; Wright, L, 2009) | 0.35 |
| "The present study aimed to assess the effect of resveratrol on the bioavailability of nicardipine in rats." | ( Effect of resveratrol on the pharmacokinetics of oral and intravenous nicardipine in rats: possible role of P-glycoprotein inhibition by resveratrol. Choi, BC; Choi, JS; Kang, KW, 2009) | 0.35 |
| " However, there is concern about the bioavailability of these agents pertinent to the poor absorption and thereby limiting its clinical use." | ( Liposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice. Narayanan, BA; Narayanan, NK; Nargi, D; Randolph, C, 2009) | 0.35 |
| " These effects are observed despite its extremely low bioavailability and rapid clearance from the circulation due to extensive sulfation and glucuronidation in the intestine and liver." | ( Antitumor activity of resveratrol and its sulfated metabolites against human breast cancer cells. Haslinger, E; Jäger, W; Kunert, O; Miksits, M; Svoboda, M; Szekeres, T; Thalhammer, T; Wlcek, K, 2009) | 0.35 |
| " After validation, the methods were applied to the assessment of the bioavailability and distribution of trans-resveratrol in rats after the intravenous administration of 15 mg/kg." | ( Quantification of trans-resveratrol and its metabolites in rat plasma and tissues by HPLC. Juan, ME; Maijó, M; Planas, JM, 2010) | 0.36 |
| " These data suggest that 1) oral resveratrol is attractive candidate as an agent capable of combating dioxin toxicity and 2) increasing the bioavailability of this polyphenol enhances its protective effect." | ( Attenuation of 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity by resveratrol: a comparative study with different routes of administration. Akamine, A; Hashiguchi, I; Ike, A; Ishida, T; Ishii, Y; Koga, T; Kuramoto, C; Takeda, T; Taketoh, J; Yahata, M; Yamada, H, 2009) | 0.35 |
| " As resveratrol has low bioavailability and interacts with multiple molecular targets, the development of new molecules with better bioavailability and targeting sirtuin at lower concentrations is a promising field of the medicinal chemistry." | ( Sirtuin activators. Alcaín, FJ; Villalba, JM, 2009) | 0.35 |
| " Enhanced bioavailability may thus be a major factor contributing to the neuroprotective activity of pinostilbene." | ( Protective effects of pinostilbene, a resveratrol methylated derivative, against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. Chang, RC; Chao, J; Cheng, KW; Li, H; Wang, M; Yu, MS, 2010) | 0.36 |
| " Many valuable properties such as cardioprotective and anticarcinogenic activity have been attributed to resveratrol; however, its bioavailability is quite low." | ( Wine, resveratrol and health: a review. Cantos-Villar, E; García-Parrilla, MC; Guerrero, RF; Puertas, B, 2009) | 0.35 |
| " This mini-review summarizes recent studies on the possible mechanisms of action, potential therapeutic uses, and bioavailability of the nonalcoholic constituents of alcoholic beverages, in particular resveratrol and other polyphenols." | ( The biological responses to resveratrol and other polyphenols from alcoholic beverages. Brown, L; Chan, V; Das, DK; Das, S; Feick, P; Kroon, PA; Singer, MV; Tosaki, A, 2009) | 0.35 |
| " In vivo, these effects could result in reduced activation of procarcinogens and/or in drug bioavailability limitation." | ( CYP1A1 and CYP3A4 modulation by dietary flavonoids in human intestinal Caco-2 cells. Dupont, I; Larondelle, Y; Pussemier, L; Schneider, YJ; Scippo, ML; Sergent, T; Van der Heiden, E, 2009) | 0.35 |
| "The potential for colloidal carriers to increase drug bioavailability has spurred a renewed interest in their uptake mechanisms and movement within cells." | ( The evidence for solid lipid nanoparticles mediated cell uptake of resveratrol. Kristl, J; Teskac, K, 2010) | 0.36 |
| "One of the approaches to increasing the bioavailability of resveratrol is to protect its 3-OH phenolic group." | ( Regioselective lipase-catalyzed synthesis of 3-o-acyl derivatives of resveratrol and study of their antioxidant properties. Ballesteros, A; Jimenez-Barbero, J; Plou, FJ; Poveda, A; Torres, P, 2010) | 0.36 |
| " As a drawback, its bioavailability is very limited due to the fast metabolic alterations to which it is subjected in the plasma." | ( Metabolic effects of resveratrol in mammals--a link between improved insulin action and aging. Durand, C; Fröjdö, S; Pirola, L, 2008) | 0.35 |
| " Moreover, the bioavailability of resveratrol in the brain remains uncertain." | ( AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. Chandakkar, P; Davies, P; Ferruzzi, MG; Giliberto, L; Janle, EM; Lobo, J; Marambaud, P; Simon, JE; Vingtdeux, V; Wu, Q; Zhao, H, 2010) | 0.36 |
| "trans-Resveratrol, a natural antioxidant, has been described as a nutraceutic compound with important beneficial effects on health, but its low oral bioavailability hinders its therapeutic activity." | ( Multidrug resistance proteins restrain the intestinal absorption of trans-resveratrol in rats. González-Pons, E; Juan, ME; Planas, JM, 2010) | 0.36 |
| " Our study thus demonstrated for the first time that trans-resveratrol is the bioactive form in medulloblastoma cells in which the expression of brain-associated SULTs was down-regulated, resulting in the increased intracellular bioavailability and anti-medulloblastoma efficacy of trans-resveratrol." | ( Identification of metabolic pattern and bioactive form of resveratrol in human medulloblastoma cells. Chen, XY; Fu, YS; Kong, QY; Li, H; Liu, J; Ma, JX; Shu, XH; Sun, Y; Sun, Z; Wang, JM; Wang, Q; Wu, ML, 2010) | 0.36 |
| " Given the important role of the breast cancer resistance protein (ABCG2/BCRP) in the efflux of conjugated forms, the present study investigates the bioavailability and tissue distribution of trans-resveratrol and its metabolites after the oral administration of 60 mg/kg in Bcrp1(-/-) mice." | ( Involvement of breast cancer resistance protein (BCRP1/ABCG2) in the bioavailability and tissue distribution of trans-resveratrol in knockout mice. Alfaras, I; Alvarez, AI; Juan, ME; Merino, G; Pérez, M; Planas, JM; Prieto, JG, 2010) | 0.36 |
| " Although there has been remarkable evidence for resveratrol as a potent chemopreventive agent in vitro, it seems that the low bioavailability of resveratrol in humans could interfere with a successful in vivo treatment." | ( Fighting cancer with red wine? Molecular mechanisms of resveratrol. Efferth, T; Kraft, TE; Parisotto, D; Schempp, C, 2009) | 0.35 |
| " Toxicity, pharmacokinetics and clinical bioavailability of resveratrol are also reviewed in this article." | ( Resveratrol and liver disease: from bench to bedside and community. Bishayee, A; Darvesh, AS; McGory, R; Politis, T, 2010) | 0.36 |
| " Our results indicate that resveratrol alleviates type 1 diabetes-induced vasculopathy by decreasing vascular oxidative stress and thereby increasing the bioavailability of nitric oxide without changing metabolic abnormalities." | ( Resveratrol shows vasoprotective effect reducing oxidative stress without affecting metabolic disturbances in insulin-dependent diabetes of rabbits. Akar, F; Gokalp, B; Ozturk, K; Pektas, MB; Sepici, A; Soylemez, S; Surucu, HS; Tufan, C; Ulus, AT, 2011) | 0.37 |
| " Since their low bioavailability is a major obstacle to biomedical applications, efforts are being made to improve their absorption and slow down phase II metabolism." | ( Determination of quercetin and resveratrol in whole blood--implications for bioavailability studies. Biasutto, L; Garbisa, S; Marotta, E; Paradisi, C; Zoratti, M, 2010) | 0.36 |
| " We describe the underlying mechanisms, but also focus on possible limitations and how they might be overcome in future clinical use--either by chemically synthesized derivatives or special formulations that improve bioavailability and pharmacokinetics." | ( Potential of the dietary antioxidants resveratrol and curcumin in prevention and treatment of hematologic malignancies. Dicato, M; Diederich, M; Jacob, C; Kelkel, M, 2010) | 0.36 |
| " The metabolism of resveratrol and its bioavailability also warrant further consideration in light of recent in vitro and in vivo studies." | ( Resveratrol: challenges in translation to the clinic--a critical discussion. Bhattacharya, S; Kenealey, J; Polans, AS; Subramanian, L; van Ginkel, PR; Youssef, S, 2010) | 0.36 |
| " Considerable debate appears to exist on the dose and bioavailability of resveratrol, leading to the controversies on its effectiveness." | ( Effects of Longevinex (modified resveratrol) on cardioprotection and its mechanisms of action. Bak, I; Das, DK; Lekli, I; Mukherjee, S; Ray, D; Tosaki, A, 2010) | 0.36 |
| "When administered orally, pterostilbene demonstrates greater bioavailability and total plasma levels of both the parent compound and metabolites than does resveratrol." | ( Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats. Huang, Z; Kapetanovic, IM; McCormick, DL; Muzzio, M; Thompson, TN, 2011) | 0.37 |
| " These results serve to highlight the contrasting effects on different activities brought about by methoxylation, which is widely employed as a structural modification approach to improve potency and bioavailability of resveratrol." | ( Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties. Go, ML; Zhang, W, 2011) | 0.37 |
| " Extensive metabolism in the intestine and liver results in an oral bioavailability considerably less than 1%." | ( Bioavailability of resveratrol. Walle, T, 2011) | 0.37 |
| " However, an important issue with the future development of resveratrol for disease management is its low bioavailability due to its rapid metabolism in mammals." | ( Resveratrol in cancer management: where are we and where we go from here? Ahmad, N; Kumar, R; Ndiaye, M, 2011) | 0.37 |
| " Therefore, it is of great interest to stabilize trans-resveratrol in order to preserve its biological activities and to improve its bioavailability in the brain." | ( Characterization of trans-resveratrol-loaded lipid-core nanocapsules and tissue distribution studies in rats. Battastini, AM; Bernardi, A; da Silva, T; Frozza, RL; Guterres, SS; Hoppe, JB; Paese, K; Pohlmann, AR; Salbego, C, 2010) | 0.36 |
| " Future studies should be designed to account for a disease process in which the pathogenic factors may take place for years before disease manifestations take place, the possibly limited bioavailability of polyphenols, and the potential need to provide combinations or modifications of polyphenols." | ( Polyphenols: planting the seeds of treatment for the metabolic syndrome. Cherniack, EP, 2011) | 0.37 |
| "These results highlight the importance of studying the bioavailability of the assayed compounds in the experimental models used to be able to choose the best route of administration depending on the target organ and to determine which compounds or derived metabolites are effective treating the studied disease." | ( Lack of effect of oral administration of resveratrol in LPS-induced systemic inflammation. Azorín-Ortuño, M; Espín, JC; García-Conesa, MT; Larrosa, M; Tomás-Barberán, F; Yañez-Gascón, MJ, 2011) | 0.37 |
| " However, RSV's bioavailability is compromised by its physicochemical properties, such as low stability, increased oxidation on heat and light exposure, low water solubility and also its high hepatic uptake." | ( New delivery systems to improve the bioavailability of resveratrol. Ribeiro, AJ; Santos, AC; Veiga, F, 2011) | 0.37 |
| " To achieve an optimal response of RSV, new strategies are still required to enhance its bioavailability and reduce its perceived toxicity." | ( New delivery systems to improve the bioavailability of resveratrol. Ribeiro, AJ; Santos, AC; Veiga, F, 2011) | 0.37 |
| " We used a formulation that increases oral bioavailability to assess the mechanisms involved in the glucoregulatory action of RSV in high-fat diet (HFD)-fed diabetic wild type mice." | ( Resveratrol increases glucose induced GLP-1 secretion in mice: a mechanism which contributes to the glycemic control. Barra, Y; Barthélemy, S; Burcelin, R; Champion, S; Dao, TM; Drucker, DJ; Klopp, P; Pechere, L; Sérée, E; Serino, M; Vachoux, C; Waget, A, 2011) | 0.37 |
| " Stabilized "nutraceutical" formulations of resveratrol with high absorption rate are essential to examine its potential medical benefits since dietary polyphenols are known to be rapidly metabolized by gut microflora and oxidized during absorption." | ( Resveratrol may be beneficial in treatment of diabetic foot syndrome. Assaad-Khalil, S; Bashmakov, YK; Petyaev, IM, 2011) | 0.37 |
| " However, the poor in vivo bioavailability of resveratrol due to its rapid metabolism is being considered as a major obstacle in translating its effects in humans." | ( Enhancing the bioavailability of resveratrol by combining it with piperine. Ahmad, N; Bailey, HH; Johnson, JJ; Mukhtar, H; Nihal, M; Scarlett, CO; Siddiqui, IA, 2011) | 0.37 |
| "Our study demonstrated that piperine significantly improves the in vivo bioavailability of resveratrol." | ( Enhancing the bioavailability of resveratrol by combining it with piperine. Ahmad, N; Bailey, HH; Johnson, JJ; Mukhtar, H; Nihal, M; Scarlett, CO; Siddiqui, IA, 2011) | 0.37 |
| " Overall, the results demonstrated that pterostilbene had more potent inhibitory effects on colon cancer cells than resveratrol, which may be associated with the superior bioavailability of pterostilbene to resveratrol." | ( Inhibitory effects of resveratrol and pterostilbene on human colon cancer cells: a side-by-side comparison. Decker, EA; Dong, P; McClements, DJ; Nutakul, W; Qiu, P; Sobers, HS; Xiao, H, 2011) | 0.37 |
| "The therapeutic promise of trans-resveratrol (tRes) is limited by poor bioavailability following rapid metabolism." | ( Natural prenylated resveratrol analogs arachidin-1 and -3 demonstrate improved glucuronidation profiles and have affinity for cannabinoid receptors. Bratton, SM; Brents, LK; Doerksen, RJ; Liu, H; Medina-Bolivar, F; Nair, V; Nopo-Olazabal, L; Patel, RY; Prather, PL; Radominska-Pandya, A; Seely, KA, 2012) | 0.38 |
| "Prenylated stilbenoids may be preferable alternatives to tRes due to increased bioavailability via slowed metabolism." | ( Natural prenylated resveratrol analogs arachidin-1 and -3 demonstrate improved glucuronidation profiles and have affinity for cannabinoid receptors. Bratton, SM; Brents, LK; Doerksen, RJ; Liu, H; Medina-Bolivar, F; Nair, V; Nopo-Olazabal, L; Patel, RY; Prather, PL; Radominska-Pandya, A; Seely, KA, 2012) | 0.38 |
| " This has strong implications for in vivo absorption as the enzymatic activity of gut microflora could enhance the bioavailability of β-glycosides of dietary polyphenols." | ( In vitro absorption of dietary trans-resveratrol from boiled and roasted peanuts in Caco-2 cells. Chukwumah, Y; Verghese, M; Vogler, B; Walker, L, 2011) | 0.37 |
| " Oxidative stress can decrease the bioavailability of nitric oxide (*NO) in vessels." | ( Antioxidant effects of resveratrol and other stilbene derivatives on oxidative stress and *NO bioavailability: Potential benefits to cardiovascular diseases. Bonnefont-Rousselot, D; Borderie, D; Frombaum, M; Le Clanche, S, 2012) | 0.38 |
| " Despite the therapeutic effects of resveratrol, its pharmacokinetic properties are not favorable since this compound has poor bioavailability being rapidly and extensively metabolized and excreted." | ( Resveratrol in medicinal chemistry: a critical review of its pharmacokinetics, drug-delivery, and membrane interactions. Lima, JL; Lucio, M; Neves, AR; Reis, S, 2012) | 0.38 |
| "Trans-3,5,4'-trihydroxystilbene (trans-resveratrol, RES) exhibits very low bioavailability due to extensive conjugative metabolism." | ( Analytical method development for synthesized conjugated metabolites of trans-resveratrol, and application to pharmacokinetic studies. Canney, DJ; Iwuchukwu, OF; Nagar, S; Sharan, S, 2012) | 0.38 |
| " The low oral bioavailability indicated for this polyphenol, with the intestine as a bottleneck to its absorption, has promoted the large intestine as a potential target site for its chemopreventive activity." | ( Colorectal cancer chemoprevention by trans-resveratrol. Alfaras, I; Juan, ME; Planas, JM, 2012) | 0.38 |
| " The levels of brain-associated SULT (SULT1A1, SULT1C2, and SULT4A1) expression in U251 cells were lower than those in LN229 cells, suggesting the inverse relationship of SULT-mediated sulfonation activity with high intracellular resveratrol bioavailability and resveratrol sensitivity of human GBM cells." | ( Distinct sulfonation activities in resveratrol-sensitive and resveratrol-insensitive human glioblastoma cells. Chen, XY; Kong, QY; Li, H; Liu, J; Shi, H; Shu, XH; Sun, Z; Wu, ML, 2012) | 0.38 |
| " The absolute bioavailability of TMS was 45." | ( [Trimethoxystilbene and its effects on the proliferation and apoptosis of PASMCs]. Gao, G; Gao, J; Hu, J; Jiang, X; Wang, X; Xiang, D; Xie, L, 2012) | 0.38 |
| " The bioavailability of TMS was to 45%." | ( [Trimethoxystilbene and its effects on the proliferation and apoptosis of PASMCs]. Gao, G; Gao, J; Hu, J; Jiang, X; Wang, X; Xiang, D; Xie, L, 2012) | 0.38 |
| " The current review focuses on the role of these efflux pumps located in the intestine on the low oral bioavailability of trans-resveratrol." | ( The bioavailability and distribution of trans-resveratrol are constrained by ABC transporters. Alfaras, I; Colom, H; Juan, ME; Planas, JM, 2012) | 0.38 |
| " In order to provide more information regarding absorption, metabolism, and bioavailability of resveratrol, various research approaches have been performed, including in vitro, ex vivo, and in vivo models." | ( Resveratrol biosynthesis: plant metabolic engineering for nutritional improvement of food. De Gara, L; Giovinazzo, G; Ingrosso, I; Paradiso, A; Santino, A, 2012) | 0.38 |
| " This suggests that dietary intake of this compound can enhance the bioavailability of resveratrol in the human body." | ( Enzymatic synthesis of piceid glucosides using maltosyltransferase from Caldicellulosiruptor bescii DSM 6725. Baek, NI; Cha, J; Choi, KH; Hwang, S; Kim, J; Park, H; Yang, SJ, 2012) | 0.38 |
| " The bioavailability of resveratrol is highly influenced by several factors such as the food matrix and, therefore, this study has been compared with a pilot study in which men ingested grape extract (GE) tablets as a nutraceutical, containing similar total amounts of resveratrol than RW." | ( Pharmacokinetics of resveratrol metabolic profile in healthy humans after moderate consumption of red wine and grape extract tablets. Andres-Lacueva, C; Escribano, E; Estruch, R; Rotches-Ribalta, M; Urpi-Sarda, M, 2012) | 0.38 |
| " However, for many polyphenol compounds of natural origin bioavailability is limited by low solubility in biological fluids, as well as by rapid metabolization in vivo." | ( Using liposomes as carriers for polyphenolic compounds: the case of trans-resveratrol. Bonechi, C; Ciani, L; Lamponi, S; Martini, S; Rebmann, H; Ristori, S; Rossi, C, 2012) | 0.38 |
| "Due to the low bioavailability of resveratrol, determining whether its metabolites exert any beneficial effect is an interesting issue." | ( Delipidating effect of resveratrol metabolites in 3T3-L1 adipocytes. Andrés-Lacueva, C; Churruca, I; Eseberri, I; Lasa, A; Portillo, MP, 2012) | 0.38 |
| "Resveratrol exerts a variety of biological and pharmacological activities, which are observed despite its extremely low bioavailability and rapid clearance from the circulation due to extensive sulfation and glucuronidation in the intestine and liver." | ( Gut and microbial resveratrol metabolite profiling after moderate long-term consumption of red wine versus dealcoholized red wine in humans by an optimized ultra-high-pressure liquid chromatography tandem mass spectrometry method. Andres-Lacueva, C; Boto-Ordoñez, M; Chiva-Blanch, G; Corella, D; Estruch, R; Guillen, M; Jaeger, W; Jauregui, O; Llorach, R; Perez-Garcia, L; Rotches-Ribalta, M; Tinahones, FJ; Urpi-Sarda, M, 2012) | 0.38 |
| " Moreover, we evaluated endothelial function by dose-relaxation curves to acetylcholine, hepatic NO bioavailability and TXA2 production." | ( Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats. Bosch, J; Di Pascoli, M; Diví, M; García-Pagán, JC; Gracia-Sancho, J; Rodríguez-Vilarrupla, A; Rosado, E; Vilaseca, M, 2013) | 0.39 |
| " Our findings of the effective reduction of amyloid aggregation of lysozyme by polyphenol mixtures in vitro are of the utter physiological relevance considering the bioavailability and low toxicity of tested phenols." | ( Amyloid aggregation of lysozyme: the synergy study of red wine polyphenols. Gazova, Z; Kurin, E; Mučaji, P; Nagy, M; Siposova, K, 2013) | 0.39 |
| " To overcome these problems, we developed two novel resveratrol nanodelivery systems based on lipid nanoparticles to enhance resveratrol's oral bioavailability for further use in medicines, supplements, and nutraceuticals." | ( Novel resveratrol nanodelivery systems based on lipid nanoparticles to enhance its oral bioavailability. Lima, JL; Lúcio, M; Martins, S; Neves, AR; Reis, S, 2013) | 0.39 |
| " This discrepancy is due to the bioavailability of resveratrol." | ( [Resveratrol: distribution, properties and perspectives]. Abdelazid, K; Bonet-Costa, V; Borrás, C; El Alami, M; Gambini, J; Inglés, M; López-Grueso, R; Olaso-González, G; Viña, J, ) | 0.13 |
| " The single dose (40 mg) of the soluble t-Res was well absorbed and elicited biologically efficient blood levels (0." | ( Optimization of trans-Resveratrol bioavailability for human therapy. Amiot, MJ; Burcelin, R; Ciccolini, J; Dao, TM; Emond, C; Fanciullino, R; Pechere, L; Romier, B; Savouret, JF; Seree, E, 2013) | 0.39 |
| ", low bioavailability but high bioactivity, is a conundrum not yet solved in which the final responsible actor (if any) for the exerted effects has not yet been unequivocally identified." | ( Resveratrol and clinical trials: the crossroad from in vitro studies to human evidence. Espín, JC; García-Conesa, MT; González-Sarrías, A; Larrosa, M; Tomás-Barberán, FA; Tomé-Carneiro, J, 2013) | 0.39 |
| "Altogether, our data provide significant new insight into the molecular mechanism of RSV and support the notion that despite low bioavailability in vivo, RSV biological effects could be mediated by its metabolites." | ( Resveratrol metabolites inhibit human metastatic colon cancer cells progression and synergize with chemotherapeutic drugs to induce cell death. Aires, V; Cotte, AK; Delmas, D; Ghiringhelli, F; Latruffe, N; Limagne, E, 2013) | 0.39 |
| " However, its low water-solubility and bioavailability could limit its use in both food and pharmaceutical fields." | ( Reversed phase High Performance Liquid Chromatography used for the physicochemical and thermodynamic characterization of piceatannol/β-cyclodextrin complex. Amira-Guebailia, H; Houache, O; Messiad, H, 2013) | 0.39 |
| " It emerged that the poor bioavailability of these nutraceuticals poses an obstacle to their exerting adequate anti-cancer potential." | ( Nutraceuticals as new treatment approaches for oral cancer: II. Green tea extracts and resveratrol. Chaushu, G; Dayan, A; Dayan, D; Salo, T; Vered, M; Zlotogorski, A, 2013) | 0.39 |
| "These results indicate that influence of the processing could improve the bioavailability of gallic acid and reduce the absorption of PM-SG, polydatin and emodin in rats." | ( Influence of processing on pharmacokinetic of typical constituents in radix polygoni multiflori after oral administration by LC-ESI-MS/MS. Chang, YX; Gao, XM; He, J; Li, J; Ma, WF; Zhang, BL; Zhang, L; Zhang, P; Zheng, F, 2013) | 0.39 |
| " Future studies which characterize the bioavailability and efficacy of resveratrol supplementation are critical to provide evidence for its long-term health benefits." | ( Resveratrol vs. calorie restriction: data from rodents to humans. Lam, YY; Peterson, CM; Ravussin, E, 2013) | 0.39 |
| " Its bioavailability is low and raises the possibility that the metabolites of resveratrol have biological effects." | ( Resveratrol 3-O-D-glucuronide and resveratrol 4'-O-D-glucuronide inhibit colon cancer cell growth: evidence for a role of A3 adenosine receptors, cyclin D1 depletion, and G1 cell cycle arrest. Carew, MA; Carrington, S; Meira, LB; Modjtahedi, H; Polycarpou, E; Tyrrell, E, 2013) | 0.39 |
| " However, the biggest problem associated with this molecule, a limited bioavailability due to its fast metabolism in the liver, has led to obtaining its analogues or derivatives." | ( Resveratrol and analogues: a review of antioxidant activity and applications to human health. da Silva, AD; de Carvaho, GS; Oliveira, V; Raposo, NR; Santos, JA, 2013) | 0.39 |
| "Due to the low bioavailability of resveratrol, determining whether its metabolites exert any beneficial effect is an interesting issue." | ( Resveratrol metabolites modify adipokine expression and secretion in 3T3-L1 pre-adipocytes and mature adipocytes. Churruca, I; Eseberri, I; Lasa, A; Portillo, MP, 2013) | 0.39 |
| "It is well known that resveratrol (RSV) displayed cancer-preventing and anticancer properties but its clinical application is limited because of a low bioavailability and a rapid clearance from the circulation." | ( Synthesis and cytotoxic activity evaluation of 2,3-thiazolidin-4-one derivatives on human breast cancer cell lines. Bertamino, A; Campiglia, P; Caruso, A; Chimento, A; Gomez-Monterrey, IM; Milite, C; Musella, S; Novellino, E; Pezzi, V; Sala, M; Saturnino, C; Sinicropi, MS; Sirianni, R; Tortorella, P, 2013) | 0.39 |
| " Here we review: (a) the sources, the metabolism, and the bioavailability of resveratrol; (b) the ability of resveratrol to modulate redox signalling and to interact with multiple molecular targets of diverse intracellular pathways; (c) its protective effects against oxidative damage in cardio-cerebro-vascular districts and metabolic disorders such as diabetes; and (d) the evidence for its efficacy and toxicity in humans." | ( Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases. Bartolo, M; Carrizzo, A; Damato, A; Forte, M; Maciag, A; Puca, AA; Salzano, F; Trimarco, V; Vecchione, C, 2013) | 0.39 |
| " The present study investigated the synergistic antidepressant-like effect of trans-resveratrol and piperine, a bioavailability enhancer, in mice and explored the possible mechanism." | ( Piperine potentiates the antidepressant-like effect of trans-resveratrol: involvement of monoaminergic system. Chen, Z; Huang, W; Li, G; Lin, M; Pan, J; Wang, Q; Wu, F; Wu, S; Xie, X; Xu, Y; Yan, Q; Yu, X, 2013) | 0.39 |
| " With the aim of improving bioavailability and selectivity, the antiproliferative effects of free-, liposomed-, and immunoliposomed-curcumin and/or resveratrol formulations have been compared in two human breast cancer cell lines with different HER2 expression levels." | ( Immunoliposome encapsulation increases cytotoxic activity and selectivity of curcumin and resveratrol against HER2 overexpressing human breast cancer cells. Barrajón-Catalán, E; Catania, A; Cicirata, F; Micol, V; Nicolosi, S, 2013) | 0.39 |
| " Resveratrol suppresses MTC growth in vitro, but it has low bioavailability in vivo due to its poor water solubility and rapid metabolic breakdown, as well as lack of tumor-targeting ability." | ( Octreotide-functionalized and resveratrol-loaded unimolecular micelles for targeted neuroendocrine cancer therapy. Burke, JF; Chen, H; Gong, S; Jaskula-Sztul, R; Pilla, S; Xu, W, 2013) | 0.39 |
| "The phytochemical resveratrol has been shown to exert numerous health benefits in preclinical studies, but its rapid metabolism and resulting poor bioavailability may limit translation of these effects to humans." | ( Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence. Andreadi, C; Brenner, DE; Britton, RG; Brown, K; Brown, VA; Gescher, AJ; Horner-Glister, E; Karmokar, A; Patel, KR; Sale, S; Singh, R; Steward, WP, 2013) | 0.39 |
| " Different studies were undertaken to obtain synthetic analogs of resveratrol with major bioavailability and anticancer activity." | ( Biological activity of 3-chloro-azetidin-2-one derivatives having interesting antiproliferative activity on human breast cancer cell lines. Bertamino, A; Campana, C; Campiglia, P; Caruso, A; Chimento, A; Gomez-Monterrey, IM; Martire, E; Musella, S; Novellino, E; Parisi, OI; Pezzi, V; Puoci, F; Sala, M; Saturnino, C; Sinicropi, MS; Sirianni, R, 2013) | 0.39 |
| " This paper presents a review of the most recent studies on the complexes formed between several important types of antioxidant compounds and cyclodextrins, focusing on the contradictory data reported in the literature concerning to the antioxidant activity of the host/guest molecule complexes, the different complexation constants reported for identical complexes, the bioavailability of the antioxidant compound in the presence of cyclodextrins and recommendation concerning the use of natural or modified cyclodextrins." | ( Cyclodextrins and antioxidants. García-Carmona, F; López-Nicolás, JM; Rodríguez-Bonilla, P, 2014) | 0.4 |
| "Different O/W nanoemulsion-based delivery systems were developed in order to optimize the bioavailability of encapsulated resveratrol for potential oral administration." | ( Bioavailability of encapsulated resveratrol into nanoemulsion-based delivery systems. Balestrieri, ML; Castaldo, D; D'Onofrio, N; Donsì, F; Ferrari, G; Servillo, L; Sessa, M; Tsao, R, 2014) | 0.4 |
| "The study of the bioavailability of active compounds in functional foods, such as polyphenol-rich beverages, is required before making nutritional claims." | ( Resveratrol metabolic fingerprinting after acute and chronic intakes of a functional beverage in humans. Andres-Lacueva, C; Martí, MM; Reglero, G; Rotches-Ribalta, M; Urpi-Sarda, M, 2014) | 0.4 |
| "The biochemical activities of plant flavonoids and stilbenoids point to many health-related applications, hampered however by a low bioavailability associated with rapid metabolic modification." | ( Prodrugs of quercetin and resveratrol: a strategy under development. Biasutto, L; Zoratti, M, 2014) | 0.4 |
| " In vitro evidence of resveratrol efficacy is widespread, however, many concerns regarding its effectiveness in vivo arise from its poor stability in vitro and bioavailability following oral ingestion." | ( Chemistry, stability and bioavailability of resveratrol. d'Erme, M; Francioso, A; Masci, A; Mastromarino, P; Mosca, L, 2014) | 0.4 |
| " However, the generally low solubility, stability, bioavailability and target specificity, together with the side effects seen when used at high levels, have limited their application." | ( Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals. Moustaid-Moussa, N; Nie, S; Su, R; Sun, M; Wang, S; Wu, D; Zhang, J, 2014) | 0.4 |
| "Resveratrol has many proposed health benefits, including the prevention of cancers, but its low bioavailability is considered a limiting factor in translating these effects to humans." | ( Resveratrol-sulfates provide an intracellular reservoir for generation of parent resveratrol, which induces autophagy in cancer cells. Andreadi, C; Britton, RG; Brown, K; Patel, KR, 2014) | 0.4 |
| " We conclude intravenous resveratrol acts as an acute renal vasodilator, partially mediated by increased NO production/NO bioavailability and superoxide scavenging but not by inducing vasodilatory cyclooxygenase products." | ( Resveratrol induces acute endothelium-dependent renal vasodilation mediated through nitric oxide and reactive oxygen species scavenging. Beierwaltes, WH; Gordish, KL, 2014) | 0.4 |
| " However, its limited bioavailability and poor stability in solution hamper its use in pharmaceutical applications." | ( Improved stability of trans-resveratrol in aqueous solutions by carboxymethylated (1,3/1,6)-β-D-glucan. Boffi, A; d'Erme, M; Francioso, A; Mastromarino, P; Mosca, L; Restignoli, R, 2014) | 0.4 |
| " There are, however, comparatively fewer studies that have investigated resveratrol treatment and cancer outcomes in vivo, perhaps limited by its poor bioavailability when taken orally." | ( Resveratrol and cancer: focus on in vivo evidence. Carter, LG; D'Orazio, JA; Pearson, KJ, 2014) | 0.4 |
| " By virtue of extensive pre-systemic metabolism and existence of enterohepatic recirculation, t-RVT bioavailability is almost zero." | ( Trans-resveratrol self-nano-emulsifying drug delivery system (SNEDDS) with enhanced bioavailability potential: optimization, pharmacokinetics and in situ single pass intestinal perfusion (SPIP) studies. Pai, RS; Singh, G, 2015) | 0.42 |
| " Resveratrol, the main antioxidant in red wine, improves NO bioavailability and prevents cardiovascular disease." | ( Resveratrol decreases fructose-induced oxidative stress, mediated by NADPH oxidase via an AMPK-dependent mechanism. Chen, BZ; Cheng, PW; Cheng, WH; Ho, WY; Hsiao, M; Lu, PJ; Lu, WH; Su, YT; Sun, GC; Tseng, CJ; Yeh, TC, 2014) | 0.4 |
| " The aim of the current study was to test the hypothesis that the limited bioavailability of tRes can be improved by modifying its structure to create analogs which would be glucuronidated at a lower rate than tRes itself." | ( Novel resveratrol-based substrates for human hepatic, renal, and intestinal UDP-glucuronosyltransferases. Bratton, SM; Crooks, PA; Eddy, SD; Greer, AK; Hendrickson, HP; Madadi, NR; Mazerska, Z; Radominska-Pandya, A, 2014) | 0.4 |
| " However, there remains concern regarding low bioavailability and wide inter-individual differences in absorption and metabolism in humans, which suggests a great need to develop novel methods for resveratrol delivery." | ( Development of a lozenge for oral transmucosal delivery of trans-resveratrol in humans: proof of concept. Blanchard, OL; Friesenhahn, G; Javors, MA; Smoliga, JM, 2014) | 0.4 |
| " Therefore, the developed PEG conjugate is a favorable system for modifying the solubility and bioavailability of RES." | ( Amino acid-PEGylated resveratrol and its influence on solubility and the controlled release behavior. Chen, A; Du, H; Huang, D; Shang, Z; Song, H; Zhang, Y; Zhao, H, 2014) | 0.4 |
| " Our results suggest that polyphenolic compounds might be potential structural bases and source to find and project nature-based, safe, orally bioavailable direct thrombin inhibitors." | ( Thrombin inhibitory activity of some polyphenolic compounds. Bijak, M; Krotkiewski, H; Nowak, P; Pawlaczyk, I; Ponczek, M; Saluk, J; Wachowicz, B; Ziewiecki, R, 2014) | 0.4 |
| "Resveratrol (RSV) regulates NAD bioavailability and sirtuin-related metabolism, which relates to aging, metabolic syndrome and non-alcoholic fatty liver disease." | ( Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome activation. Lim, Y; Yang, SJ, 2014) | 0.4 |
| " The drug suffers enterohepatic recirculation and extensive first-pass metabolism by CYP3A4 in liver, resulting in very low bioavailability (almost zero)." | ( Optimized PLGA nanoparticle platform for orally dosed trans-resveratrol with enhanced bioavailability potential. Pai, RS; Singh, G, 2014) | 0.4 |
| "The current studies entail a novel formulation approach to develop systematically optimized (OPT) nanoparticles (NPs) to enhance the oral bioavailability potential using poly (dl-lactide-co-glycolide) (PLGA) of t-RVT and overcome enterohepatic recirculation." | ( Optimized PLGA nanoparticle platform for orally dosed trans-resveratrol with enhanced bioavailability potential. Pai, RS; Singh, G, 2014) | 0.4 |
| "6-fold) indicated significant enhancement in the rate and extent of bioavailability by the OPT formulation compared to pure drug and marketed product." | ( Optimized PLGA nanoparticle platform for orally dosed trans-resveratrol with enhanced bioavailability potential. Pai, RS; Singh, G, 2014) | 0.4 |
| "The studies, therefore, could provide another useful tool for successful development of t-RVT NPs and an in vivo approach to designate nanoparticulate system of t-RVT with distinctly improved bioavailability and to overcome enterohepatic recirculation." | ( Optimized PLGA nanoparticle platform for orally dosed trans-resveratrol with enhanced bioavailability potential. Pai, RS; Singh, G, 2014) | 0.4 |
| "The current studies entail successful formulation of systematically optimized (OPT) nanoparticulate drug delivery system to increase the oral bioavailability using Eudragit RL 100 of trans-resveratrol (t-RVT), and evaluate their in-vitro/in-vivo performance." | ( In-vitro/in-vivo characterization of trans-resveratrol-loaded nanoparticulate drug delivery system for oral administration. Pai, RS; Singh, G, 2014) | 0.4 |
| "25-fold) indicated significant enhancement in the rate and extent of bioavailability by the optimized trans-resveratrol-loaded Eudragit RL 100 nanoparticles (OPT-t-RVT NPs) compared with pure drug." | ( In-vitro/in-vivo characterization of trans-resveratrol-loaded nanoparticulate drug delivery system for oral administration. Pai, RS; Singh, G, 2014) | 0.4 |
| "The results, therefore, insight into the role of solubility enhancement and trounce enterohepatic recirculation for improving the oral bioavailability of t-RVT." | ( In-vitro/in-vivo characterization of trans-resveratrol-loaded nanoparticulate drug delivery system for oral administration. Pai, RS; Singh, G, 2014) | 0.4 |
| "The consumption of cacao-derived products, particularly in the form of dark chocolate is known to provide beneficial cardiovascular effects in normal individuals and in those with vascular dysfunction (reduced nitric oxide [NO] bioavailability and/or synthesis)." | ( Cell membrane mediated (-)-epicatechin effects on upstream endothelial cell signaling: evidence for a surface receptor. Ceballos, G; Moreno-Ulloa, A; Ramirez-Sanchez, I; Romero-Perez, D; Villarreal, F, 2014) | 0.4 |
| " This lack of cognitive effects may be due to low bioavailability and, in turn, reduced bioefficacy of resveratrol in vivo." | ( Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation. Dew, TP; Haskell, CF; Kennedy, DO; Reay, JL; Wightman, EL; Williamson, G, 2014) | 0.4 |
| " Its bioavailability after an oral dose is very low and therefore it is very important to make sure that plasma concentrations of free resveratrol are sufficient enough to be active as antioxidant." | ( PTEN mediates the antioxidant effect of resveratrol at nutritionally relevant concentrations. Abdelaziz, KM; Bonet-Costa, V; Borrás, C; El Alami, M; Gambini, J; Inglés, M; Miguel, MG; Viña, J, 2014) | 0.4 |
| "gov NCT01747252) revealed relatively high bioavailability and two distinctly separated plasma concentration peaks at 1 and 5 h." | ( A novel red grape cells complex: health effects and bioavailability of natural resveratrol. Azachi, M; Danon, A; Hagay, Y; Katz, A; Yatuv, R, 2014) | 0.4 |
| " To improve the drug stability, increase the bioavailability and minimize side-effects of resveratrol, novel drug delivery systems have been formulated to bring this potential candidate to the first line of disease treatment." | ( Resveratrol: review on therapeutic potential and recent advances in drug delivery. Ali, J; Baboota, S; Pangeni, R; Sahni, JK; Sharma, S, 2014) | 0.4 |
| " In the near future, resveratrol-based therapies with either resveratrol or its analogs that have better bioavailability could be useful in the treatment of diabetes and its complications, either alone or in combination with other anti-diabetic drugs." | ( Resveratrol and diabetes. Evangelopoulos, A; Kazazis, C; Vallianou, NG, 2013) | 0.39 |
| " Furthermore, many questions remain still unsolved, such as the dose or the duration of treatment to maximize its effects, the bioavailability of resveratrol and the role of food matrix to improve its bioactivity." | ( Resveratrol: a supplementation for men or for mice? Bo, S; Ponzo, V; Soldati, L, 2014) | 0.4 |
| " We also focused on analysis of RSV uptake, and on the effects of low RSV concentrations, considering the limited bioavailability of RSV in vivo." | ( Stilbenes and resveratrol metabolites improve mitochondrial fatty acid oxidation defects in human fibroblasts. Aires, V; Bastin, J; Benoist, JF; Delmas, D; Djouadi, F; Latruffe, N; Le Bachelier, C; Schlemmer, D, 2014) | 0.4 |
| " However, poor aqueous solubility and cellular bioavailability has limited its therapeutic application." | ( Lipid based nanoemulsifying resveratrol for improved physicochemical characteristics, in vitro cytotoxicity and in vivo antiangiogenic efficacy. Joshi, A; More, U; Pund, S; Thakur, R, 2014) | 0.4 |
| " Their efficacy has been tested in tumor xenografted mice and considerable experimental findings have stimulated researchers to further improve the bioavailability of these nutraceuticals." | ( Targeting cancer with nano-bullets: curcumin, EGCG, resveratrol and quercetin on flying carpets. Aras, A; Farooqi, AA; Hechenleitner, AA; Khokhar, AR; Pineda, EA; Qureshi, MZ; Silva, MF; Sobczak-Kupiec, A, 2014) | 0.4 |
| " Derivatives are under development with the aim of improving their bioavailability and/or bioefficacy." | ( Improving the efficacy of plant polyphenols. Azzolini, M; Biasutto, L; Mattarei, A; Paradisi, C; Romio, M; Sassi, N; Zoratti, M, 2014) | 0.4 |
| "7 ng/mL) and poor oral bioavailability (2." | ( Quantification of the resveratrol analogs trans-2,3-dimethoxy-stilbene and trans-3,4-dimethoxystilbene in rat plasma: application to pre-clinical pharmacokinetic studies. Cardullo, N; Lin, HS; Ng, SY; Ong, PS; Spatafora, C; Tringali, C; Yeo, SC, 2014) | 0.4 |
| " Despite the array of bioactivities that it possesses, RES has low bioavailability due to its poor aqueous solubility and dissolution properties." | ( Resveratrol-loaded nanoparticles reduce oxidative stress induced by radiation or amyloid-beta in transgenic Caenorhabditis elegans. Dong, J; Li, X; Lu, X; Si, J; Xu, H; Yin, H; Zheng, D, 2014) | 0.4 |
| " However, the methylated resveratrol analogs exhibit better bioavailability as they are more easily transported into the cell and more resistant to degradation." | ( Biosynthesis of methylated resveratrol analogs through the construction of an artificial biosynthetic pathway in E. coli. Choi, O; Hong, YS; Hwang, BY; Jang, JH; Kang, SY; Kim, CY; Lee, JK, 2014) | 0.4 |
| " To achieve an equivalent effect, a 10-fold dosage of genistein was required, thus highlighting the dose advantage of resveratrol, as poor bioavailability is a common concern for its clinical application." | ( Arsenic trioxide and resveratrol show synergistic anti-leukemia activity and neutralized cardiotoxicity. Chen, M; Fan, Y; Fang, K; Meng, J; Tu, Y; Wan, L; Yu, L; Zhu, W, 2014) | 0.4 |
| " No information about the bioavailability of these polyphenols is available." | ( Investigation of the absorption of resveratrol oligomers in the Caco-2 cellular model of intestinal absorption. Bartel, LC; Empl, MT; Michael, M; Schebb, NH; Willenberg, I; Wonik, J, 2015) | 0.42 |
| " Further, various studies demonstrated several issues associated with resveratrol which account for its poor systemic bioavailability (almost zero) due to rapid and extensive first pass metabolism and existence of enterohepatic recirculation." | ( Recent advances of resveratrol in nanostructured based delivery systems and in the management of HIV/AIDS. Pai, RS; Singh, G, 2014) | 0.4 |
| "Resveratrol, a natural compound found in grapes, has potential chemotherapy effects but very low oral bioavailability in humans." | ( Pre-formulation studies of resveratrol. Liang, D; Mock, C; Robinson, K, 2015) | 0.42 |
| "Low bioavailability severely hinders exploitation of the biomedical potential of resveratrol." | ( New water-soluble carbamate ester derivatives of resveratrol. Azzolini, M; Biasutto, L; Carraro, M; Mattarei, A; Paradisi, C; Zoratti, M, 2014) | 0.4 |
| " To test this, the effect of resveratrol on NO bioavailability was measured in thick ascending limb suspensions." | ( Resveratrol increases nitric oxide production in the rat thick ascending limb via Ca2+/calmodulin. Cabral, PD; Garvin, JL; Gonzalez-Vicente, A, 2014) | 0.4 |
| " RES treatment of bone cells results in protective effects, but dose translation from in vitro studies to clinically relevant doses is limited since bioavailability is not taken into account." | ( Resveratrol supplementation affects bone acquisition and osteoporosis: Pre-clinical evidence toward translational diet therapy. Tou, JC, 2015) | 0.42 |
| "To develop an optimized supersaturable self-nanoemulsifying drug delivery system (S-SNEDDS) in order to improve the oral bioavailability of trans-resveratrol (t-RVT), together with surmounting poor aqueous solubility, enterohepatic recirculation and controlling drug precipitation, by employing a precipitation inhibitor (PPI) that is, hydroxypropyl methylcellulose (HPMC)." | ( In vitro and in vivo performance of supersaturable self-nanoemulsifying system of trans-resveratrol. Pai, RS; Singh, G, 2016) | 0.43 |
| " However, the translational potential of resveratrol has been limited by its specificity, poor bioavailability and uncertain toxicity." | ( Resveratrol and its oligomers: modulation of sphingolipid metabolism and signaling in disease. Anthony, NG; Gray, AI; Lim, KG; Mackay, SP; Pyne, NJ; Pyne, S, 2014) | 0.4 |
| " The poor bioavailability of resveratrol in humans has been a major concern for translating basic science findings into clinical utility." | ( Enhancing the delivery of resveratrol in humans: if low bioavailability is the problem, what is the solution? Blanchard, O; Smoliga, JM, 2014) | 0.4 |
| " Resveratrol (Res) is a promising candidate for overcoming cancer chemoresistance, but it has low bioavailability due to poor absorption, and ready metabolism limits its application." | ( mPEG-b-PCL/TPGS mixed micelles for delivery of resveratrol in overcoming resistant breast cancer. Chen, M; Chen, R; Morott, J; Repka, MA; Wang, S; Wang, Y, 2015) | 0.42 |
| "Resveratrol, a potent natural antioxidant, possesses a wide range of pharmacological activities, but its oral bioavailability is very low due to its extensive hepatic and presystemic metabolism." | ( Vitamin E loaded resveratrol nanoemulsion for brain targeting for the treatment of Parkinson's disease by reducing oxidative stress. Ali, J; Baboota, S; Mustafa, G; Pangeni, R; Sharma, S, 2014) | 0.4 |
| "Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a well-known natural polyphenolic compound that has garnered considerable interest because of its bioavailability and pharmacokinetics in humans." | ( Novel antifungal mechanism of resveratrol: apoptosis inducer in Candida albicans. Lee, DG; Lee, J, 2015) | 0.42 |
| " Recently, nanotechnology-based formulations (nanoformulations) are being looked upon as a novel method for improving the pharmacokinetic properties, as well as enhancing targetability and bioavailability of resveratrol." | ( Resveratrol nanoformulations: challenges and opportunities. Jambhrunkar, S; Popat, A; Qu, Z; Soo, E; Summerlin, N; Thakur, S, 2015) | 0.42 |
| " In this work carbomer microgels were combined with agarose networks in a semi-interpenetrating polymer network structure, aiming at obtaining suitable delivery systems for the loading and release of molecules with poor bioavailability but high therapeutic interest, like resveratrol." | ( Cross-linked poly(acrylic acids) microgels and agarose as semi-interpenetrating networks for resveratrol release. Albani, D; Giordano, C; Munarin, F; Petrini, P; Prina, E; Rodilossi, S; Tunesi, M, 2015) | 0.42 |
| " This study thus aimed to elucidate brain bioavailability of trans-resveratrol by monitoring brain concentrations and dwell times following administration of resveratrol through intragastric, intraperitoneal, external carotid artery/ECA and intrathecal routes." | ( Diffusion Efficiency and Bioavailability of Resveratrol Administered to Rat Brain by Different Routes: Therapeutic Implications. Chen, XY; Gu, JY; Kong, QY; Li, H; Liu, J; Shi, S; Shu, XH; Song, X; Wang, LL; Wu, ML, 2015) | 0.42 |
| " However, its low bioavailability upon oral ingestion and lack of specificity may hamper the translation of the encouraging experimental data into human health benefits." | ( Common pathways in health benefit properties of RSV in cardiovascular diseases, cancers and degenerative pathologies. Aires, V; Delmas, D, 2015) | 0.42 |
| " Further preclinical and clinical studies are needed in order to understand safety, bioavailability and bioefficacy of dietary polyphenols in IBD patients." | ( The role of dietary polyphenols in the management of inflammatory bowel disease. Abdollahi, M; Farzaei, MH; Rahimi, R, 2015) | 0.42 |
| " Poor bioavailability is the main factor limiting the efficacy of chemopreventive agents." | ( Nanoparticles increase the efficacy of cancer chemopreventive agents in cells exposed to cigarette smoke condensate. Fenoglio, D; Filaci, G; Izzotti, A; Lee, JL; Parodi, A; Pulliero, A; Romani, M; Sinkam, PN; Soares, CP; Wu, Y, 2015) | 0.42 |
| " The strong effects of resveratrol on the mitochondrial respiratory chain and on glycolysis suggest that caution should be used in attempts to increase bioavailability of this compound in the CNS." | ( Silent information regulator 1 modulator resveratrol increases brain lactate production and inhibits mitochondrial metabolism, whereas SRT1720 increases oxidative metabolism. Beart, PM; Klugmann, M; Lau, CL; Rae, CD; Rowlands, BD; Ryall, JG; Thomas, DS, 2015) | 0.42 |
| "Nanoemulsions have been developed for the oral delivery of poorly bioavailable phenolic compounds that are sensitive to intestinal glucuronidation." | ( Involvement of the inhibition of intestinal glucuronidation in enhancing the oral bioavailability of resveratrol by labrasol containing nanoemulsions. Chang, Q; Liao, YH; Liu, CY; Liu, XM; Pan, RL; Yang, FF; Zhou, J; Zhou, M, 2015) | 0.42 |
| "To increase its bioavailability and anticancer efficacy, we have encapsulated RSV-GNPs by Coacervation method." | ( Resveratrol loaded gelatin nanoparticles synergistically inhibits cell cycle progression and constitutive NF-kappaB activation, and induces apoptosis in non-small cell lung cancer cells. Hoti, SL; Karthikeyan, S; Prasad, NR, 2015) | 0.42 |
| "Growing evidence suggests that the elevation of free fatty acids, including palmitic acid (PA), are associated with inflammation and oxidative stress, which may be involved in endothelial dysfunction, characterized by the reduced bioavailability of nitric oxide (NO) synthesized from endothelial NO synthase (eNOS)." | ( Resveratrol analog piceatannol restores the palmitic acid-induced impairment of insulin signaling and production of endothelial nitric oxide via activation of anti-inflammatory and antioxidative heme oxygenase-1 in human endothelial cells. Cheong, YK; Chung, HT; Jeong, SO; Lee, JH; Pae, HO; Park, SH; Son, Y, 2015) | 0.42 |
| " In the second part of the review we have addressed the issue of resveratrol bioavailability and the importance of wine matrix and phytocomplex highlighting the biological effects that can be obtained with nutraceuticals and resveratrol pills compared to the daily consumption of a glass of red wine." | ( Wine, alcohol and pills: What future for the French paradox? Bertelli, AA; Biagi, M, 2015) | 0.42 |
| " However, the low bioavailability of resveratrol raises questions about whether the antidiabetic effects of oral resveratrol can act directly on these tissues." | ( Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network. Baur, JA; Breen, DM; Côté, CD; Daljeet, M; Duca, FA; Filippi, BM; Lam, TK; Rasmussen, BA; Zadeh-Tahmasebi, M, 2015) | 0.42 |
| " Its limited bioavailability provides compelling evidence of the need for more suitable formulations in order to attain better clinical effectiveness." | ( Stability and solubility of trans-resveratrol are strongly influenced by pH and temperature. Kristl, J; Lavrič, Z; Zupančič, Š, 2015) | 0.42 |
| " To meet these drawbacks, some resveratrol conjugates would be useful, which would possess improved stability, uptake and bioavailability than the lead compound, and the ability to release it once it is internalized into the cell." | ( Synthesis of amphiphilic resveratrol lipoconjugates and evaluation of their anticancer activity towards neuroblastoma SH-SY5Y cell line. Cardullo, N; Chillemi, R; Greco, V; Malfa, G; Sciuto, S; Tomasello, B, 2015) | 0.42 |
| " When it was given as an oral suspension (10 mg/kg), DHS was absorbed slowly (t max 180 or 300 min) with very limited plasma exposure and absolute oral bioavailability (F = 2." | ( Determination of naturally occurring resveratrol analog trans-4,4'-dihydroxystilbene in rat plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study. Chen, W; Elhennawy, MG; Lin, HS; Xiang, X; Yeo, SC, 2015) | 0.42 |
| " For this purpose, the oral bioavailability of the encapsulated polyphenol as well as its anti-inflammatory effects in a mouse model of endotoxic shock was studied." | ( Zein-Based Nanoparticles Improve the Oral Bioavailability of Resveratrol and Its Anti-inflammatory Effects in a Mouse Model of Endotoxic Shock. Esparza, I; Gamazo, C; González-Navarro, CJ; Irache, JM; Larraneta, E; Penalva, R, 2015) | 0.42 |
| " Resveratrol has very low oral bioavailability and, from a formulation perspective, it has low solubility in water, which leads to its poor absorption upon oral administration." | ( Dendrimer nanotechnology for enhanced formulation and controlled delivery of resveratrol. Chauhan, AS, 2015) | 0.42 |
| " Some natural derivatives of resveratrol, like pterostilbene, have a better bioavailability than the parent compound." | ( Effect of substituted stilbenes on platelet function. Curini, M; Gresele, P; Guglielmini, G; Marcotullio, MC; Messina, F; Orsini, S, 2015) | 0.42 |
| " The issue of bioavailability of resveratrol is of paramount importance and is determined by its rapid elimination and the fact that its absorption is highly effective, but the first hepatic step leaves little free resveratrol." | ( Properties of Resveratrol: In Vitro and In Vivo Studies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans. Abdelaziz, KM; Bonet-Costa, V; Borras, C; Gambini, J; Gimeno-Mallench, L; Gomez-Cabrera, MC; Inglés, M; Lopez-Grueso, R; Mas-Bargues, C; Olaso, G; Vina, J, 2015) | 0.42 |
| "Trans-resveratrol affects biological systems in a multitude of ways, but its oral bioavailability is remarkably poor due to in vivo metabolization." | ( Permeation profiles of resveratrol cream delivered through porcine vaginal mucosa: Evaluation of different HPLC stationary phases. Brandão, MA; Collins, CH; da Silva, CG; de Almeida, PA; de Oliveira, MA; Ferreira, Ade O; Polonini, HC; Raposo, NR; Soldati, PP, 2015) | 0.42 |
| " In the present study, we applied the Caco-2-transwell-system in order to investigate the modulation of intestinal bioavailability by soluble fibers." | ( Investigation of the effects of soluble fibers on the absorption of resveratrol and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PHIP) in the Caco-2 cellular model of intestinal absorption. Schebb, NH; Willenberg, I; Wonik, J, 2015) | 0.42 |
| " However, research has recently focused on the investigation of other natural or synthetic compounds in order to find substances that show a higher bioactivity and/or bioavailability than resveratrol." | ( The Resveratrol Tetramer r-Viniferin Induces a Cell Cycle Arrest Followed by Apoptosis in the Prostate Cancer Cell Line LNCaP. Albers, M; Empl, MT; Steinberg, P; Wang, S, 2015) | 0.42 |
| " Chronic resveratrol consumption may increase the poor bioavailability of resveratrol or otherwise potentiate its psychological effects." | ( The effects of chronic trans-resveratrol supplementation on aspects of cognitive function, mood, sleep, health and cerebral blood flow in healthy, young humans. Dew, T; Haskell-Ramsay, CF; Kennedy, DO; Reay, JL; Wightman, EL; Williamson, G; Zhang, W, 2015) | 0.42 |
| " Therefore, resveratrol derivatives were prepared to improve bioavailability and anti-melanogenesis activity." | ( Synthesis and Biological Evaluation of Resveratrol Derivatives as Melanogenesis Inhibitors. Hwang, BY; Jo, YH; Kim, C; Kim, SB; Lee, MK; Liu, Q, 2015) | 0.42 |
| " Furthermore, RSV suffers from other issues, including limited bioavailability due to extensive hepatic metabolism." | ( Critical review of resveratrol in xenobiotic-induced hepatotoxicity. Du, K; Jaeschke, H; McGill, MR; Weemhoff, JL, 2015) | 0.42 |
| "39 fold increase in plasma apigenin levels compared to administration of apigenin alone, suggesting that co-administration of resveratrol could increase bioavailability of apigenin." | ( Resveratrol as a Bioenhancer to Improve Anti-Inflammatory Activities of Apigenin. Cho, E; Choi, I; Ha, SK; Lee, JA, 2015) | 0.42 |
| "Oxidative stress dependent-decrease in nitric oxide (NO) bioavailability plays an integral role in hypercholesterolemia-induced erectile dysfunction (ED)." | ( Resveratrol Protects and Restores Endothelium-Dependent Relaxation in Hypercholesterolemic Rabbit Corpus Cavernosum. Atabey, N; Demir, Ö; Esen, AA; Evcim, S; Gidener, S; Kefi, A; Kizer, O; Korhan, P; Murat, N, 2016) | 0.43 |
| " However, there is concern that the bioavailability of resveratrol may limit some of its clinical utility." | ( Self-emulsifying drug delivery systems as a tool to improve solubility and bioavailability of resveratrol. Abourehab, MA; Balata, GF; Essa, EA; Shamardl, HA; Zaidan, SH, 2016) | 0.43 |
| "An understanding of the chemistry and source of resveratrol, its bioavailability and the promising effects on mitochondria brings a new hope to therapy of mitochondrial dysfunction-related diseases." | ( Resveratrol and the mitochondria: From triggering the intrinsic apoptotic pathway to inducing mitochondrial biogenesis, a mechanistic view. Daglia, M; de Oliveira, MR; Hajheydari, Z; Manayi, A; Nabavi, SF; Nabavi, SM, 2016) | 0.43 |
| " By virtue of its lipophilic nature and low molecular weight, sulforaphane displays significantly higher bioavailability than the polyphenol-based dietary supplements that also activate Nrf2." | ( Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician's Expectation Be Matched by the Reality? Coombes, JS; Fassett, RG; Houghton, CA, 2016) | 0.43 |
| " In vivo studies revealed nearly five-fold increase in the bioavailability of SR-1 (AUC0→∞=3411 ± 170." | ( A novel monolithic controlled delivery system of resveratrol for enhanced hepatoprotection: nanoformulation development, pharmacokinetics and pharmacodynamics. Ahmad, FJ; Ahmad, I; Ahmad, S; Iqbal, Z; Singh, A, 2016) | 0.43 |
| " Similarly absorption rate constant (Ka), fraction absorbed (Fab) and effective permeability (Peff) of FEX were increased significantly in ileum of RSV and VER pretreated groups when compared to FEX alone group." | ( Effect of resveratrol on the pharmacokinetics of fexofenadine in rats: Involvement of P-glycoprotein inhibition. Bedada, SK; Neerati, P; Yellu, NR, 2016) | 0.43 |
| "007), and nitric oxide synthase inhibition (with L-NG-nitroarginine methyl ester) normalized these blood pressure differences, suggesting improved nitric oxide bioavailability underlies the hemodynamic alterations in the Resv-treated offspring." | ( Perinatal Resveratrol Supplementation to Spontaneously Hypertensive Rat Dams Mitigates the Development of Hypertension in Adult Offspring. Bourque, SL; Care, AS; Davidge, ST; Dyck, JR; Gragasin, FS; Panahi, S; Sung, MM, 2016) | 0.43 |
| " Among many reasons, inefficient systemic delivery and bioavailability of promising chemopreventive agents are considered to significantly contribute to such a disconnection." | ( Impact of nanotechnology on the delivery of natural products for cancer prevention and therapy. Sanna, V; Siddiqui, IA, 2016) | 0.43 |
| " In present study, we assessed the effects of trans-resveratrol used in combination with piperine, commonly known as a bioavailability enhancer, on chronic unpredictable mild stress-induced depressive-like behaviors and relevant molecular targets." | ( Piperine potentiates the effects of trans-resveratrol on stress-induced depressive-like behavior: involvement of monoaminergic system and cAMP-dependent pathway. An, Y; Lin, M; Pan, J; Wang, G; Wu, F; Xu, X; Xu, Y; Yu, Y; Zhang, C, 2016) | 0.43 |
| " Other natural stilbenes derived from resveratrol such as pterostilbene or piceatannol, display higher oral bioavailability and bioactivity than the parent compound, but are far less abundant in natural sources." | ( Production of highly bioactive resveratrol analogues pterostilbene and piceatannol in metabolically engineered grapevine cell cultures. Bru-Martínez, R; Cusidó, RM; Martínez-Márquez, A; Morante-Carriel, JA; Palazon, J; Ramírez-Estrada, K, 2016) | 0.43 |
| " The studies demonstrated that the composite liposome could generate potent cytotoxicity against the drug-resistant MCF-7/Adr tumor cells in vitro and enhance the bioavailability and the tumor-retention of the drugs in vivo." | ( Combination Therapy using Co-encapsulated Resveratrol and Paclitaxel in Liposomes for Drug Resistance Reversal in Breast Cancer Cells in vivo. Guo, F; Liang, W; Meng, J; Wang, C; Xu, H; Yang, XD, 2016) | 0.43 |
| " The bioavailability of resveratrol is, however, not favorable, due to its poor water-solubility and extensive metabolism." | ( [Resveratrol in Pharmaceutical Chemistry]. Noszál, B; Orgován, G, 2015) | 0.42 |
| " However, poor efficacy and bioavailability have prevented the use of resveratrol in clinics." | ( 4-(E)-{(p-tolylimino)-methylbenzene-1,2-diol}, 1 a novel resveratrol analog, differentially regulates estrogen receptors α and β in breast cancer cells. Abdalla, F; Bhat, HK; Bhat, NK; Chatterjee, A; Dandawate, P; Padhye, S; Ronghe, A; Singh, B, 2016) | 0.43 |
| " Moreover, due to the limited pharmacokinetic parameters of resveratrol, multiple strategies aimed at increasing the bioavailability of resveratrol have also been addressed." | ( Resveratrol and Alzheimer's Disease: Mechanistic Insights. Ahmed, T; Braidy, N; Javed, S; Nabavi, SF; Nabavi, SM; Šamec, D; Tariq, A; Tejada, S, 2017) | 0.46 |
| " However, its clinical application is limited because of a low oral bioavailability with high adsorption but rapid metabolism and low tissue concentrations." | ( Resveratrol and Its Analogs As Antitumoral Agents For Breast Cancer Treatment. Caruso, A; Chimento, A; Pezzi, V; Saturnino, C; Sinicropi, MS; Sirianni, R, 2016) | 0.43 |
| " Unfortunately, low bioavailability and rapid degradation to less active metabolites limit the use of this compound in a practical medicine." | ( [Biological multifunctionality of resveratrol and its derivatives]. Książek, K; Kuczmarska, A; Mikuła-Pietrasik, J, 2015) | 0.42 |
| " A growing body of evidence supports the hypothesis that phenolic phytochemicals with poor bioavailability are possibly acting primarily through remodeling of the gut microbiota." | ( Resveratrol Attenuates Trimethylamine-N-Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota. Chen, ML; Mi, MT; Ran, L; Yang, J; Yi, L; Zhang, QY; Zhang, Y; Zhou, X; Zhu, JD, 2016) | 0.43 |
| " The consequence of these alterations is a reduced bioavailability of nitric oxide (NO) with implications for aspects such as control of vascular tone and low grade inflammation." | ( Effects of exercise training and resveratrol on vascular health in aging. Gliemann, L; Hellsten, Y; Nyberg, M, 2016) | 0.43 |
| "Resveratrol (3,4',5-trihydroxy-trans-stilbene; RES) produces a variety of pharmacological effects; however, its oral bioavailability (BA) approaches zero." | ( Development of a Solid Dispersion System for Improving the Oral Bioavailability of Resveratrol in Rats. Chang, CW; Hsu, MC; Wong, CY; Wu, YT, 2017) | 0.46 |
| " However, its low bioavailability and rapid metabolism to its glucuronate and sulfate conjugates has opened a debate on the mechanisms underlying its bioactivity." | ( Cytotoxic, Antiangiogenic and Antitelomerase Activity of Glucosyl- and Acyl- Resveratrol Prodrugs and Resveratrol Sulfate Metabolites. Carda, M; Dupont, A; Falomir, E; Lucas, R; Martí-Centelles, R; Morales, JC; Peñalver, P; Zafra-Gómez, A, 2016) | 0.43 |
| " In this study, we investigated the possibility of improving the dermal bioavailability of the poorly water-soluble drug resveratrol by nanocrystal technology." | ( Enhancing Topical Delivery of Resveratrol through a Nanosizing Approach. Caddeo, C; Fadda, AM; Lai, F; Pini, E; Pireddu, R; Sinico, C; Valenti, D, 2017) | 0.46 |
| "Resveratrol (RV) 1, a plant polyphenol, has proven effective in commercial products yet drawbacks include low bioavailability due to rapid metabolism." | ( Synthesis and skin gene analysis of 4'-acetoxy-resveratrol (4AR), therapeutic potential for dermal applications. Acerson, MJ; Andrus, MB; Lephart, ED, 2016) | 0.43 |
| " To overcome the poor oral bioavailability of both compounds and improve patient compliance, a novel self-microemulsifying formulation containing curcumin together with resveratrol was developed." | ( A Novel Self-Microemulsifying System for the Simultaneous Delivery and Enhanced Oral Absorption of Curcumin and Resveratrol. Jaisamut, P; Wiwattanapatapee, R; Wiwattanawongsa, K, 2017) | 0.46 |
| "The fact that 74% of the cancer drugs are derived from natural sources, naturally occurring polyphenols or its simple analogs with improved bioavailability may have the potential to be cancer drugs in the future." | ( Polyphenol compounds and PKC signaling. Das, J; Ramani, R; Suraju, MO, 2016) | 0.43 |
| " We also cover recent pharmacologic efforts to improve the poor bioavailability of resveratrol and influence the transition between body systems in humans." | ( Resveratrol: How Much Wine Do You Have to Drink to Stay Healthy? Weiskirchen, R; Weiskirchen, S, 2016) | 0.43 |
| " However, due to its occurrence in plants more in glycosidic form as piceid, the bioavailability and bioactivity are limited." | ( Bioconversion of piceid to resveratrol by selected probiotic cell extracts. Basholli-Salihu, M; Mueller, M; Mulla, D; Praznik, W; Schuster, R; Viernstein, H, 2016) | 0.43 |
| "Reactive oxygen species (ROS) decreases bioavailability of nitric oxide (NO) and impairs NO-dependent relaxations." | ( Hydrogen sulfide: A novel mechanism for the vascular protection by resveratrol under oxidative stress in mouse aorta. Ahmed, A; Dereli, MV; Ozzayım, O; Sevin, G; Yetik-Anacak, G, 2016) | 0.43 |
| " However, the anticancer effects of triacetylresveratrol (TRES, an acetylated analog of RES) which has higher bioavailability have not been well established." | ( In vitro comparative studies of resveratrol and triacetylresveratrol on cell proliferation, apoptosis, and STAT3 and NFκB signaling in pancreatic cancer cells. Duan, J; E, J; Gu, J; Lu, SE; Malhotra, J; Tan, XL; Xu, F; Yue, W, 2016) | 0.43 |
| "88-times increase of bioavailability in the brain by intranasal Res-NSs in situ gel formulation." | ( Fabrication of an ionic-sensitive in situ gel loaded with resveratrol nanosuspensions intended for direct nose-to-brain delivery. Chen, W; Hao, J; Jin, K; Tang, H; Tong, T; Zhang, S; Zhao, J; Zhuang, Q, 2016) | 0.43 |
| "Despite the therapeutic effects of resveratrol, its clinical application is restricted by its poor oral bioavailability and low water solubility." | ( Resveratrol cross-linked chitosan loaded with phospholipid for controlled release and antioxidant activity. Jeong, H; Kim, NH; Lee, DW; Lee, JH; Samdani, KJ; Yoo, DH; Yoo, IS, 2016) | 0.43 |
| " Furthermore, the potential preventive activity of curcumin and resveratrol should be evaluated in long-term exposure clinical trials, using preparations with high bioavailability and that are well standardized." | ( Curcumin and Resveratrol in the Management of Cognitive Disorders: What is the Clinical Evidence? Di Giacomo, S; Mazzanti, G, 2016) | 0.43 |
| " OS reduces the bioavailability of nitric oxide (NO), which has been associated with hypertension, arteriosclerosis, and a reduced vasodilatory response." | ( The effects of resveratrol on aging vessels. Austin, C; Azzawi, M; Degens, H; Diaz, M; Vanhees, L, 2016) | 0.43 |
| " Owing to a difference in the affinity of T3 and Toc for the α-tocopherol transfer protein, the bioavailability of orally ingested T3 is lower than that of Toc." | ( Synergistic Anticancer Effect of Tocotrienol Combined with Chemotherapeutic Agents or Dietary Components: A Review. Eitsuka, T; Miyazawa, T; Nakagawa, K; Nishida, H; Tatewaki, N, 2016) | 0.43 |
| "Nanosizing is frequently used as formulation approach to increase the bioavailability of poorly water-soluble drugs." | ( Systematical investigation of a combinative particle size reduction technology for production of resveratrol nanosuspensions. Liu, T; Möschwitzer, JP; Müller, RH, 2017) | 0.46 |
| " Resveratrol crosses the blood-brain barrier, and lumbar puncture (LP) greatly increases its bioavailability in rat brains; therefore, we investigated the effectiveness of LP-administered resveratrol on orthotopic rat glioblastomas." | ( Lumbar puncture-administered resveratrol inhibits STAT3 activation, enhancing autophagy and apoptosis in orthotopic rat glioblastomas. Hong, L; Jia, L; Jia-Yao, G; Jie, B; Li-Li, W; Lin, S; Mo-Li, W; Pei-Nan, L; Peng, Z; Qian, W; Qing-You, K; Shun, S; Xiao-Hong, S; Xiao-Yan, C; Xue, S, 2016) | 0.43 |
| " The limited bioavailability of resveratrol may further impede its potential effects." | ( Resveratrol and Lifespan in Model Organisms. Chin, D; Pallauf, K; Rimbach, G; Rupp, PM; Wolf, IM, 2016) | 0.43 |
| "The aim of this review is to focus on various studies related to chemical composition l, pharmacological activities, bioavailability problems associated with resveratrol." | ( Research Problems Associated with Resveratrol (trans-3, 5, 4'- trihydroxystilbene; RSV) and Various Strategies to Overcome those Problems (Review). Garg, R; Sardana, S, 2017) | 0.46 |
| "If bioavailability is such a limitation in the clinical application of resveratrol, then methods need to be optimized for resveratrol formulations." | ( Research Problems Associated with Resveratrol (trans-3, 5, 4'- trihydroxystilbene; RSV) and Various Strategies to Overcome those Problems (Review). Garg, R; Sardana, S, 2017) | 0.46 |
| "Delivery of the natural anti-inflammatory compound resveratrol with nanoemulsions can dramatically improve its tissue targeting, bioavailability and efficacy." | ( Development and characterization of resveratrol nanoemulsions carrying dual-imaging agents. Bagia, C; Cavanaugh, JE; Herneisey, M; Janjic, JM; Liu, L; Mirtic, J; Potdar, S; Williams, J, 2016) | 0.43 |
| "Resveratrol (RSV) has been shown to effectively suppress chronic rhinosinusitis with nasal polyps in a mouse model; however, when locally administered to the sinonasal cavity, bolus RSV is limited by low drug bioavailability owing to its low aqueous solubility and relatively rapid clearance from the administration site." | ( Sinonasal Delivery of Resveratrol via Mucoadhesive Nanostructured Microparticles in a Nasal Polyp Mouse Model. Choy, YB; Huh, BK; Khalmuratova, R; Kim, SN; Lee, M; Lee, SH; Park, CG; Park, JW; Shin, HW, 2017) | 0.46 |
| " Resveratrol is a promising anti-restenotic natural drug but subject to low bioavailability when systemically administered." | ( Restenosis Inhibition and Re-differentiation of TGFβ/Smad3-activated Smooth Muscle Cells by Resveratrol. Binder, BY; DiRenzo, D; Goel, SA; Guo, LW; Ke, J; Kent, A; Kent, KC; Li, L; Little, C; Murphy, WL; Roenneburg, DA; Shi, XD; Shi, Y; Takayama, T; Urabe, G; Wang, B; Zhang, M; Zhou, Y; Zhu, Y, 2017) | 0.46 |
| "Pterostilbene, a structural analog of resveratrol, has higher oral bioavailability and bioactivity than that of the parent compound; but is far less abundant in natural sources." | ( De novo biosynthesis of pterostilbene in an Escherichia coli strain using a new resveratrol O-methyltransferase from Arabidopsis. Heo, KT; Hong, YS; Kang, SY, 2017) | 0.46 |
| "Despite various beneficial biological properties, resveratrol lacks therapeutic applications because of poor bioavailability due to variable absorption and extensive metabolism." | ( Increased intestinal permeation and modulation of presystemic metabolism of resveratrol formulated into self-emulsifying drug delivery systems. Charrueau, C; Dairou, J; Eto, B; Limas Nzouzi, N; Mamadou, G; Ponchel, G, 2017) | 0.46 |
| " SNEDDS formulation components were rationally selected and optimized for maximum drug loading by applying the design of experiments and further evaluated for stability in simulated gastrointestinal fluids, functional stability of antioxidants, in vitro release, Caco-2 cell uptake, oral bioavailability and prophylactic anticancer activity." | ( α-Tocopherol as functional excipient for resveratrol and coenzyme Q10-loaded SNEDDS for improved bioavailability and prophylaxis of breast cancer. Agrawal, AK; Dora, CP; Garg, T; Jain, S; Kushwah, V; Thanki, K, 2017) | 0.46 |
| " However, poor bioavailability of resveratrol is a potential limitation for resveratrol treatment and cancer outcome in vivo." | ( Resveratrol as MDR reversion molecule in breast cancer: An overview. Alamolhodaei, NS; Hayes, AW; Karimi, G; Ramezani, M; Tsatsakis, AM, 2017) | 0.46 |
| " Future human studies should address the appropriate dose range and low bioavailability of resveratrol." | ( Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults. Anghel, V; Barzilai, N; Bonkowski, MS; Coleville, AJ; Crandall, JP; Golden, A; Hawkins, M; Kim, S; Kulkarni, AS; Moaddel, R; O'Broin, P; Pollack, RM; Powell, D; Sinclair, DA; Stein, D; Zhang, K, 2017) | 0.46 |
| "Isorhapontigenin, an orally bioavailable dietary polyphenol, displayed superior anti-inflammatory effects compared with resveratrol." | ( Isorhapontigenin, a bioavailable dietary polyphenol, suppresses airway epithelial cell inflammation through a corticosteroid-independent mechanism. Barnes, PJ; Donnelly, LE; Fenwick, PS; Lin, HS; Yeo, SCM, 2017) | 0.46 |
| " However, their poor aqueous solubility and bioavailability limit their clinical use." | ( Alginate Nanoparticles Containing Curcumin and Resveratrol: Preparation, Characterization, and In Vitro Evaluation Against DU145 Prostate Cancer Cell Line. Dash, AK; Saralkar, P, 2017) | 0.46 |
| " Different types of formulations have been designed for the improvement of bioavailability of these compounds, nanonization being one of the most notable approaches among them." | ( Polyphenol nanoformulations for cancer therapy: experimental evidence and clinical perspective. Abdollahi, M; Bahramsoltani, R; Davatgaran-Taghipour, Y; Farzaei, MH; Karimi-Soureh, Z; Masoomzadeh, S; Rahimi, R, 2017) | 0.46 |
| " Concurrent administration of RES and QUR was able to enhance the bioavailability of RES." | ( Co-encapsulated resveratrol and quercetin in chitosan and peg modified chitosan nanoparticles: For efficient intra ocular pressure reduction. Kandasamy, R; Muthusamy, S; Natesan, S; Palanichamy, R; Pandian, S; Ponnusamy, C, 2017) | 0.46 |
| " Indeed, several studies have implicated this bioavailability trait as a major road-block to resveratrol's potential clinical applications." | ( Toward Resolving the Resveratrol Conundrum: Synthesis and Adsool, VA; Cui, YT; Goh, YL; Pendharkar, V, 2017) | 0.46 |
| "Sulfotransferase activity modulates metabolism of resveratrol in adipocytes with potential consequences on bioavailability and thus metabolic action of this polyphenol." | ( Role of sulfotransferases in resveratrol metabolism in human adipocytes. Barron, D; Chabert, C; Gheldof, N; Hager, J; Moco, S; Teav, T, 2017) | 0.46 |
| "The effect of diabetes on the pharmacokinetics, bioavailability and brain distribution of grape polyphenols and select metabolites was studied in the Zucker diabetic fatty (ZDF) rat model." | ( Influence of diabetes on plasma pharmacokinetics and brain bioavailability of grape polyphenols and their phase II metabolites in the Zucker diabetic fatty rat. Chen, TY; Cooper, B; Ferruzzi, MG; Ho, L; Janle, EM; Pasinetti, GM; Simon, JE; Talcott, ST; Todd, G; Wang, J; Wu, QL, 2017) | 0.46 |
| "Diabetes may alter the overall bioavailability of some polyphenols in plasma and brain in part due to higher urinary clearance." | ( Influence of diabetes on plasma pharmacokinetics and brain bioavailability of grape polyphenols and their phase II metabolites in the Zucker diabetic fatty rat. Chen, TY; Cooper, B; Ferruzzi, MG; Ho, L; Janle, EM; Pasinetti, GM; Simon, JE; Talcott, ST; Todd, G; Wang, J; Wu, QL, 2017) | 0.46 |
| " Moreover, its poor solubility in water and low bioavailability are the challenging issues." | ( Anticonvulsant activity of resveratrol-loaded liposomes in vivo. Akkaya, H; Aslan, I; Erdogan, CS; Ethemoglu, MS; Kilic, E; Seker, FB; Yilmaz, B, 2017) | 0.46 |
| " However, a key problem is their short half-life and low bioavailability under in vivo conditions." | ( Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. Benlloch, M; Castellano, G; Dellinger, RW; Estrela, JM; Mena, S; Obrador, E; Salvador, R, 2017) | 0.46 |
| " Quite often however their instability, extensive metabolization, low bioavailability and poor solubility limit their application in cancer prevention and therapy." | ( Nanoparticle formulations to enhance tumor targeting of poorly soluble polyphenols with potential anticancer properties. Bonferoni, MC; Ferrari, F; Rossi, S; Sandri, G, 2017) | 0.46 |
| "This study involved physical and pharmacokinetic characterizations of trans-resveratrol (t-Rev)-loaded saLMPMs which attempted to improve t-Rev's pharmacokinetic profiles and bioavailability resolving hurdles limiting its potential health benefits." | ( Physical and Pharmacokinetic Characterizations of trans-Resveratrol (t-Rev) Encapsulated with Self-Assembling Lecithin-based Mixed Polymeric Micelles (saLMPMs). Chen, LC; Chen, LG; Ho, HO; Li, TP; Liu, DZ; Sheu, MT; Su, CY; Wong, WP, 2017) | 0.46 |
| " We have previously reported that resveratrol and synthetic analogs of resveratrol with a higher bioavailability inhibit the synthesis of androgens in human adrenocortical H295R cells." | ( Resveratrol, piceatannol and analogs inhibit activation of both wild-type and T877A mutant androgen receptor. Lundqvist, J; Oskarsson, A; Tringali, C, 2017) | 0.46 |
| "We hypothesized that metabolites of dietary flavonoids attenuate impairments in nitric oxide (NO) bioavailability evoked by glucotoxic conditions mimicking Type 1 or 2 diabetes." | ( Metabolites of flavonoid compounds preserve indices of endothelial cell nitric oxide bioavailability under glucotoxic conditions. Babu, PVA; Jalili, T; Qian, Y; Symons, JD, 2017) | 0.46 |
| " Due to complicated pharmacokinetic profile of resveratrol that is characterized by very low bioavailability in spite of high oral absorption, the effects of resveratrol is being studied in new nanotechnology preparations of pharmaceutical formulation." | ( [Targeted drug delivery system: potential application to resveratrol]. Farghali, H; Kameníková, L, ) | 0.13 |
| " However, the poor water solubility and low bioavailability of resveratrol limit its clinical applications." | ( Resveratrol and inflammatory bowel disease. Jiang, B; Miao, M; Shi, Y; Zhou, J, 2017) | 0.46 |
| "Drug nanosuspension is one of the established methods to improve the bioavailability of poorly soluble drugs." | ( Production of drug nanosuspensions: effect of drug physical properties on nanosizing efficiency. Liu, T; Möschwitzer, JP; Müller, RH, 2018) | 0.48 |
| " However, the low bioavailability of resveratrol makes it worthwhile to explore newer compounds with similar properties." | ( Protective effects of the resveratrol analog piceid in dopaminergic SH-SY5Y cells. Cavanaugh, JE; Parmar, MS; Potdar, S; Ray, SD, 2018) | 0.48 |
| " We have conjugated resveratrol, a natural polyphenol, and 3-(5-methoxy, 2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propen-1-one (MOMIPP), a chalcone, to HA with the goal of enhancing drug bioavailability and targeting triple negative breast cancers." | ( Receptor-Mediated Attachment and Uptake of Hyaluronan Conjugates by Breast Cancer Cells. Crowder, DC; Ditto, AJ; Maltese, WA; Overmeyer, JH; Shah, KN; Tavana, H; Yun, YH, 2017) | 0.46 |
| " Therefore, many researchers focused on designing and synthesizing the derivatives of resveratrol to enhance the bioavailability and the pharmacological activity of resveratrol." | ( Therapeutic Versatility of Resveratrol Derivatives. Deng, S; Li, C; Ma, X; Nawaz, W; Shu, X; Zhou, Z, 2017) | 0.46 |
| " However, the actual in vivo effect of the inhibitory ability on oral bioavailability is yet verified." | ( Effects of Ganoderma, Rhodiola and grape seed extracts on the glucuronidation and oral bioavailability of resveratrol in rats. Chang, Q; Cong, Z; Liao, Y; Liu, C; Liu, X; Pan, R; Yang, F; Zhou, M, 2019) | 0.51 |
| " A highly active nano-formulation of resveratrol (XAR™) with enhanced bioavailability is now available." | ( Stem Cells and Progenitors in Human Peripheral Blood Get Activated by Extremely Active Resveratrol (XAR™). Bhartiya, D; Chhabria, S; Jadhav, V; Tripathi, A; Tripathi, V, 2018) | 0.48 |
| "In this work, in order to enhance the stability, bioavailability and antioxidant activity of insoluble antioxidants used into juice, yoghourt and nutritional supplements, the oligo-hyalurosomes nano-delivery system (CRHs) based on oligo-hyaluronic acid -curcumin (oHC) polymer loaded curcumin(Cur) and resveratrol (Res) was fabricated with new nanotechnolgy." | ( Co-encapsulation of curcumin and resveratrol into novel nutraceutical hyalurosomes nano-food delivery system based on oligo-hyaluronic acid-curcumin polymer. Chen, D; Guo, C; Yin, J, 2018) | 0.48 |
| "Self-microemulsifying (SME) drug delivery system has been developed to increase oral bioavailabilities, and inhibitory excipients are capable of improving oral bioavailability by inhibiting enzyme mediated intestinal metabolism." | ( Improving oral bioavailability of resveratrol by a UDP-glucuronosyltransferase inhibitory excipient-based self-microemulsion. Chang, Q; Cong, ZQ; Hu, X; Liao, YH; Liu, CY; Liu, XM; Pan, RL; Yang, FF; Zhou, J, 2018) | 0.48 |
| " However, the polyphenol due to its rapid and extensive metabolism exhibits low bioavailability in vivo." | ( Physiological uptake and retention of radiolabeled resveratrol loaded gold nanoparticles ( Chadha, VD; Dhawan, DK; Kamal, R, 2018) | 0.48 |
| " Further drug-like property analysis demonstrated that the optimized compound, 8d (WI-1758), had liver microsomal metabolic stability, was well tolerated (>2000 mg/kg), and had a rational pharmacokinetic profile, as well as an oral bioavailability of 14." | ( Design, Synthesis, and Evaluation of Orally Bioavailable Quinoline-Indole Derivatives as Innovative Multitarget-Directed Ligands: Promotion of Cell Proliferation in the Adult Murine Hippocampus for the Treatment of Alzheimer's Disease. Chan, ASC; Feng, X; Hu, J; Huang, L; Li, X; Wang, Z; Yang, X, 2018) | 0.48 |
| " Because of its effectiveness in increasing the permanence and bioavailability of resveratrol in the intestinal epithelium, we investigated whether the effect of resveratrol-loaded in poly(anhydride) nanoparticles reduce oxidative stress and promote myenteric neuroprotection in the ileum of rats subjected to I/R." | ( Evaluation of the treatment with resveratrol-loaded nanoparticles in intestinal injury model caused by ischemia and reperfusion. Borges, SC; Buttow, NC; Cavalcanti, OA; da Silva, LM; de Paula Werner, MF; Ferreira, PEB; Irache, JM, 2018) | 0.48 |
| " However, its low levels of aqueous solubility, stability, and poor bioavailability limit its application." | ( Resveratrol liposomes and lipid nanocarriers: Comparison of characteristics and inducing browning of white adipocytes. Fan, Z; Overby, H; Ren, G; Wang, S; Zhao, L; Zu, Y, 2018) | 0.48 |
| " After oral administration of DRG fully solubilized by 2-hydroxypropyl-β-cyclodextrin (HP-β-CD), the plasma profiles of DRG were highly erratic with a low absolute bioavailability (F < 9." | ( Quantification of desoxyrhapontigenin (4-methoxyresveratrol) in rat plasma by LC-MS/MS: Application to pre-clinical pharmacokinetic study. Chen, H; Dai, Y; Lin, HS; Ong, PS; Tan, ALC; Wu, J; Xiang, X, 2018) | 0.48 |
| " However, the oral bioavailability of these compounds in humans is low (˂1-2%)." | ( The Oral Bioavailability of Trans-Resveratrol from a Grapevine-Shoot Extract in Healthy Humans is Significantly Increased by Micellar Solubilization. Behnam, D; Bosy-Westphal, A; Calvo-Castro, LA; David, F; Ehrt, H; Frank, J; Schiborr, C; Sus, N; Voggel, J, 2018) | 0.48 |
| "The oral bioavailability of trans-resveratrol from the grapevine-shoot extract Vineatrol30 was significantly increased using a liquid micellar formulation, without any treatment-related adverse effects, making it a suitable system for improved supplementation of trans-resveratrol." | ( The Oral Bioavailability of Trans-Resveratrol from a Grapevine-Shoot Extract in Healthy Humans is Significantly Increased by Micellar Solubilization. Behnam, D; Bosy-Westphal, A; Calvo-Castro, LA; David, F; Ehrt, H; Frank, J; Schiborr, C; Sus, N; Voggel, J, 2018) | 0.48 |
| " In addition, the bioavailability of these polyphenols is usually very low due to their poor absorption in the gut." | ( Curcumin and dietary polyphenol research: beyond drug discovery. Jin, TR, 2018) | 0.48 |
| "The objectives of this study were to investigate the following: 1) the bioavailability of resveratrol consumed in combination with curcumin after consumption of a high-fat meal; and 2) the acute combined effects of this combination on the postprandial inflammatory response of subjects with abdominal obesity." | ( Supplementation with Resveratrol and Curcumin Does Not Affect the Inflammatory Response to a High-Fat Meal in Older Adults with Abdominal Obesity: A Randomized, Placebo-Controlled Crossover Trial. Couillard, C; Couture, P; Gigleux, I; Lamarche, B; Marin, J; Paradis, ME; Vohl, MC; Vors, C, 2018) | 0.48 |
| "Kinetics of resveratrol and identified metabolites revealed rapid absorption patterns but also relatively limited bioavailability based on free resveratrol concentrations." | ( Supplementation with Resveratrol and Curcumin Does Not Affect the Inflammatory Response to a High-Fat Meal in Older Adults with Abdominal Obesity: A Randomized, Placebo-Controlled Crossover Trial. Couillard, C; Couture, P; Gigleux, I; Lamarche, B; Marin, J; Paradis, ME; Vohl, MC; Vors, C, 2018) | 0.48 |
| " It was reported that the complex resveratrol-methyl β-cyclodextrin (RV-CD) improves resveratrol's stability and bioavailability and increases its antioxidant activity." | ( Resveratrol-cyclodextrin complex affects the expression of genes associated with lipid metabolism in bovine in vitro produced embryos. Echeverri, J; Gutiérrez-Adán, A; Hamdi, M; López-Herrera, A; Millán de la Blanca, MG; Rizos, D; Sánchez-Calabuig, MJ; Torres, V; Urrego, R, 2018) | 0.48 |
| " We have demonstrated the utility of PAMAM dendrimers for enhancing solubility, stability and oral bioavailability of various drugs." | ( Dendrimers for Drug Delivery. Chauhan, AS, 2018) | 0.48 |
| " However, the clinical applications of Resveratrol are limited due to its low bioavailability and rapid metabolism, while its natural glycosilated precursor Polydatin shows better metabolic stability and major abundance in fresh fruits and vegetables." | ( Polydatin, Natural Precursor of Resveratrol, Promotes Osteogenic Differentiation of Mesenchymal Stem Cells. Ballini, A; De Maria, S; Di Benedetto, A; Grano, M; Mori, G; Muzio, LL; Porro, C; Posa, F; Ravagnan, G; Trotta, T, 2018) | 0.48 |
| " The present study takes the advantages of nanocarriers combined with a ligand (galactose) anchoring to orally deliver RES in an attempt to improve its bioavailability and pharmacological activity." | ( Galactosylated PLGA nanoparticles for the oral delivery of resveratrol: enhanced bioavailability and in vitro anti-inflammatory activity. Li, S; Lin, H; Siu, FY; Ye, S, 2018) | 0.48 |
| " After oral administration, RES-GNPs significantly enhanced the oral bioavailability of RES, up to 335." | ( Galactosylated PLGA nanoparticles for the oral delivery of resveratrol: enhanced bioavailability and in vitro anti-inflammatory activity. Li, S; Lin, H; Siu, FY; Ye, S, 2018) | 0.48 |
| " Taken together, these results suggest that t-RV can mitigate the AHG-induced EDR damage through a mechanism involving ROS scavenging and probably an increase in the bioavailability of NO." | ( t-Resveratrol Protects against Acute High Glucose Damage in Endothelial Cells. Álvarez, R; Balada, C; Flores, G; Guzmán, L; Knox, M; Martínez, JL; Vinet, R, 2018) | 0.48 |
| " However, its bioavailability problems have limited its use encouraging the search for new alternatives agents." | ( In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues. da Silva, AD; Esteves, B; Lacerda, LM; Macedo, GC; Pinto, NCC; Santos, JAD; Scio, E; Souza, IO; Zimmermann-Franco, DC, 2018) | 0.48 |
| " Results demonstrated that extrusion significantly increased the tamoxifen oral bioavailability (p < 0." | ( Development of Hot Melt Extruded Solid Dispersion of Tamoxifen Citrate and Resveratrol for Synergistic Effects on Breast Cancer Cells. Bagde, A; Chowdhury, N; Kutlehria, S; Patel, K; Singh, M; Vhora, I, 2018) | 0.48 |
| " However, its biological activity is limited by a poor bioavailability when taken orally." | ( Increased Oral Bioavailability of Resveratrol by Its Encapsulation in Casein Nanoparticles. González-Navarro, CJ; Irache, JM; Larrañeta, E; Morales, J; Peñalva, R; Peñuelas, I; Quincoces, G, 2018) | 0.48 |
| " However, its low oral bioavailability has often limited the translation of in vitro activities to in vivo effects." | ( Intranasal administration of resveratrol successfully prevents lung cancer in A/J mice. Allémann, E; Cuendet, M; Furrer, P; Monteillier, A; Voisin, A, 2018) | 0.48 |
| " This is why it is widely studied in terms of activities, bioavailability and quantitation in different foods, beverages and biological matrices." | ( Quantification of trans-resveratrol and its metabolites in human plasma using ultra-high performance liquid chromatography tandem quadrupole-orbitrap mass spectrometry. Brochot, A; Defoort, C; Martin, JC; Paut, C; Svilar, L; Tourniaire, F, 2019) | 0.51 |
| " Furthermore, RV bioavailability depends on several factors such as dose, associated food matrix, or time of ingestion." | ( Health Effects of Resveratrol: Results from Human Intervention Trials. Lamuela-Raventós, RM; Laveriano-Santos, EP; Marhuenda-Muñoz, M; Ramírez-Garza, SL; Storniolo, CE; Tresserra-Rimbau, A; Vallverdú-Queralt, A, 2018) | 0.48 |
| " Its rapid metabolism and low bioavailability have been addressed by the use of bio enhancers and nano-formulations." | ( Resveratrol: from enhanced biosynthesis and bioavailability to multitargeting chronic diseases. Bhatnagar, A; Pannu, N, 2019) | 0.51 |
| "Resveratrol, because of its low solubility in water and its high membrane permeability, is collocated in the second class of the biopharmaceutical classification system, with limited bioavailability due to its dissolution rate." | ( Solid Dispersion of Resveratrol Supported on Magnesium DiHydroxide (Resv@MDH) Microparticles Improves Oral Bioavailability. Arcuri, C; Bastianini, M; Bastioli, F; Brecchia, G; Codini, M; Fioretti, B; Iannitti, RG; Mancinelli, L; Menchetti, L; Monarca, L; Nakashidze, I; Ragonese, F; Spogli, R, 2018) | 0.48 |
| " However, oral bioavailability of JBP485 is limited due to the impaired absorptive function during intestinal injury." | ( Resveratrol enhances the protective effects of JBP485 against indomethacin-induced rat intestinal damage in vivo and vitro through up-regulating oligopeptide transporter 1 (Pept1). Huo, X; Liu, K; Liu, Z; Ma, X; Meng, Q; Shu, R; Sun, H; Sun, P; Wang, C; Wu, J, 2019) | 0.51 |
| " However, polyphenols have a low oral bioavailability mainly due to an extensive biotransformation mediated by phase I and phase II reactions in enterocytes and liver but also by gut microbiota." | ( Bioactivity of dietary polyphenols: The role of metabolites. Aprotosoaie, AC; Bujor, A; Luca, SV; Macovei, I; Miron, A; Skalicka-Woźniak, K; Trifan, A, 2020) | 0.56 |
| " Given its low bioavailability and extensive metabolism, clinical studies using resveratrol have not always replicated in vitro observations." | ( Resveratrol and Its Human Metabolites-Effects on Metabolic Health and Obesity. Moco, S; Springer, M, 2019) | 0.51 |
| " However, the medicinal application of resveratrol is constrained by its poor bioavailability and stability." | ( Derivatives and Analogues of Resveratrol: Recent Advances in Structural Modification. Deora, GS; Li, QS; Li, Y; Ruan, BF, 2019) | 0.51 |
| " Although the clinical utility of resveratrol is well documented, the rapid metabolism and poor bioavailability have limited its therapeutic use." | ( Health benefits of resveratrol: Evidence from clinical studies. Gupta, SC; Kaschula, CH; Maiti, P; Rai, V; Singh, AP; Singh, R; Verma, SS, 2019) | 0.51 |
| " Unfortunately, this compound exhibits low bioavailability and solubility." | ( Health benefits of resveratrol administration. Aebisher, D; Bartusik-Aebisher, D; Galiniak, S, 2019) | 0.51 |
| " However, the application of Res was limited by its poor bioavailability and liver targeting." | ( Synthesis, cytotoxicity and liver targeting of 3-O-β-D-Galactosylated Resveratrol. Chen, W; Hong, L; Qian, J; Wang, B; Zha, L; Zhang, C, 2019) | 0.51 |
| "On the whole, Gal-Res increased cellular uptake to HepG2 cells, bioavailability and liver targeting, providing its future clinical application in the treatment of liver diseases." | ( Synthesis, cytotoxicity and liver targeting of 3-O-β-D-Galactosylated Resveratrol. Chen, W; Hong, L; Qian, J; Wang, B; Zha, L; Zhang, C, 2019) | 0.51 |
| " However, its low bioavailability and rapid metabolic degradation has led to the suspicion that many of the biological activities of this compound observed in vitro may not be attainable in humans." | ( Resveratrol-Loaded Lipid Nanocarriers Are Internalized By Endocytosis in Yeast. Barbosa, C; Côrte-Real, M; Gerós, H; Lúcio, M; Martins, V; Oliveira, MECDR; Santos-Pereira, C; Soares, I; Terra-Matos, J, 2019) | 0.51 |
| " Moreover, the use of nanotechnology-based carriers in the delivery of plant-derived anticancer agents, such as RSV, has already demonstrated to surpass the poor water solubility, instability and reduced bioavailability associated with phytochemicals, improving their therapeutic activity, thus prompting pharmaceutical developments." | ( Targeting Cancer Via Resveratrol-Loaded Nanoparticles Administration: Focusing on In Vivo Evidence. Caldas, M; Ferreira, L; Figueiras, A; Magalhães, M; Pereira, I; Pereira-Silva, M; Ribeiro, AJ; Santos, AC; Veiga, F, 2019) | 0.51 |
| " Despite the potential benefits of RES, its effective use is limited due to its poor solubility, photosensitivity and rapid metabolism, which strongly undermine RES bioavailability and bioactivity." | ( Nanotechnology-based formulations for resveratrol delivery: Effects on resveratrol in vivo bioavailability and bioactivity. Caldas, M; Collado-González, M; Ferreira, L; Figueiras, A; Magalhães, M; Pereira, I; Pereira-Silva, M; Ribeiro, AJ; Santos, AC; Veiga, F, 2019) | 0.51 |
| " RES bioavailability is less than 1 owing to its low solubility and extensive intestinal and hepatic metabolism." | ( Nanosized Transferosome-Based Intranasal In Situ Gel for Brain Targeting of Resveratrol: Formulation, Optimization, In Vitro Evaluation, and In Vivo Pharmacokinetic Study. Abou-Taleb, HA; Kharshoum, RM; Naguib, DM; Salem, HF, 2019) | 0.51 |
| "The poor water solubility and oral bioavailability of many lipophilic polyphenols can be improved through the use of colloidal delivery systems." | ( Encapsulation of Lipophilic Polyphenols into Nanoliposomes Using pH-Driven Method: Advantages and Disadvantages. Liu, C; Liu, W; McClements, DJ; Peng, S; Zhou, W; Zou, L, 2019) | 0.51 |
| " Unfortunately, resveratrol suffers from poor bioavailability that inhibits its accumulation in target tissues, including fat, thus hindering the realization of its therapeutic potential." | ( Development of microparticles for controlled release of resveratrol to adipose tissue and the impact of drug loading on particle morphology and drug release. Annamalai, P; Gower, RM; Hendley, MA; Isely, C; Jabbari, E; Kader, S; Murphy, KP, 2019) | 0.51 |
| " Numerous nanoformulations, including solid lipid nanoparticles, polymeric nanoparticles, micelles, and liposomes, have been formulated to enhance the bioavailability and stability, as well as the therapeutic efficacy of polyphenols." | ( Pharmaceutical Topical Delivery of Poorly Soluble Polyphenols: Potential Role in Prevention and Treatment of Melanoma. Ashby, CR; Chauhan, H; Heenatigala Palliyage, G; Singh, S; Tiwari, AK, 2019) | 0.51 |
| "Resveratrol (RSV) has attracted interest as an alternative drug for the treatment of acute lung injury (ALI) and other pulmonary diseases, but its poor oral bioavailability is a limitation." | ( Orally delivered resveratrol-loaded lipid-core nanocapsules ameliorate LPS-induced acute lung injury via the ERK and PI3K/Akt pathways. Bernardi, A; de Oliveira, MTP; de Sá Coutinho, D; Martins, MA; Pohlmann, AR; Silva, PMR; Stanisçuaski Guterres, S; Tenório de Souza, É, 2019) | 0.51 |
| " Isorhapontigenin possesses greater oral bioavailability than resveratrol and has also been identified to possess anti-cancer and anti-inflammatory properties." | ( Isorhapontigenin, a resveratrol analogue selectively inhibits ADP-stimulated platelet activation. Albadawi, DAI; Chaggar, V; Dash, PR; Patel, K; Patra, PH; Ravishankar, D; Salamah, M; Vaiyapuri, R; Vaiyapuri, S; Watson, KA; Williams, HF, 2019) | 0.51 |
| " The two systems were loaded with resveratrol (RSV), a hydrophobic polyphenol endowed with anti-cancerogenic, anti-inflammatory, and heart/brain protective effects, but with low bioavailability mainly due to poor aqueous solubility." | ( Chitosan Oleate Coated Poly Lactic-Glycolic Acid (PLGA) Nanoparticles versus Chitosan Oleate Self-Assembled Polymeric Micelles, Loaded with Resveratrol. Bonferoni, MC; Catenacci, L; Dacarro, G; Ferrari, F; Malavasi, L; Miele, D; Rossi, S; Sandri, G; Sorrenti, M, 2019) | 0.51 |
| " Bioavailability evidence of closely related structural monomers could be applicable to their dimeric forms." | ( Natural dimers of coumarin, chalcones, and resveratrol and the link between structure and pharmacology. Diederich, MF; Menezes, JCJMDS, 2019) | 0.51 |
| "The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs." | ( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019) | 0.51 |
| " There has been a continually increasing interest to formulate nanoformulations of phytochemicals by using various nanocarriers, such as liposomes, micelles, nanoemulsions, and nanoparticles, to improve their bioavailability and target specificity, thereby maximizing the therapeutic potential." | ( Phytochemicals based chemopreventive and chemotherapeutic strategies and modern technologies to overcome limitations for better clinical applications. Ansari, MI; Arora, D; Sharma, PK; Singh, VK, 2019) | 0.51 |
| " However, low water solubility and extensive first-pass metabolism lead to poor bioavailability of resveratrol, hindering its potential." | ( Switching from Conventional to Nano-natural Phytochemicals to Prevent and Treat Cancers: Special Emphasis on Resveratrol. Ahmed, MB; Lee, YS; Shehzad, A, 2019) | 0.51 |
| " Considering the poor bioavailability of resveratrol, particularly due to its low aqueous solubility, we aimed to identify analogues of resveratrol with improved pharmacokinetic properties and higher binding affinities towards PPAR-γ." | ( In silico Discovery of Resveratrol Analogues as Potential Agents in Treatment of Metabolic Disorders. Goločorbin-Kon, S; Lalić-Popović, M; Mikov, M; Pavlović, N; Stanimirov, B; Stankov, K; Đanić, M, 2019) | 0.51 |
| " However, its low levels of aqueous solubility, stability, and poor bioavailability limit its application, especially when used as a free drug." | ( Anti-breast cancer activity of resveratrol encapsulated in liposomes. Cao, YN; Cui, SH; Guo, ST; Liang, Z; Sun, J; Wu, Q; Zhang, SB; Zhao, YN; Zhen, YH; Zhi, DF, 2020) | 0.56 |
| " Despite its pharmacological properties, the poor bioavailability of resveratrol has been an important barrier that hinders its application as an anticonvulsant." | ( Micronized resveratrol shows promising effects in a seizure model in zebrafish and signalizes an important advance in epilepsy treatment. Aguiar, GPS; Almeida, ER; Decui, L; Garbinato, CLL; Mazon, SC; Müller, LG; Oliveira, JV; Schneider, SE; Siebel, AM, 2020) | 0.56 |
| " It appears that poor absorption and bioavailability of natural compounds may be one of the reasons for realizing their full potential." | ( Potential of phytochemicals as immune-regulatory compounds in atopic diseases: A review. Naura, AS; Sharma, S, 2020) | 0.56 |
| " These results suggest that pterostilbene might be a potential anticancer agent targeting both cancer cells and cancer stem-like cells of cervical cancer via the superior bioavailability to resveratrol." | ( Pterostilbene Suppresses both Cancer Cells and Cancer Stem-Like Cells in Cervical Cancer with Superior Bioavailability to Resveratrol. Choi, YS; Han, JM; Jung, HJ; Shin, HJ, 2020) | 0.56 |
| " Despite the positive properties of RSV, there are various factors that limit its effectiveness, including low aqueous solubility, low oral bioavailability and chemical instability." | ( Recent Strategies in Resveratrol Delivery Systems. Díaz, DD; Fernández, MA; Machado, ND, 2019) | 0.51 |
| " These molecules have poor bioavailability that may remain as the limiting factor in their clinical effects." | ( Natural polyphenols in preclinical models of epilepsy. Dhir, A, 2020) | 0.56 |
| " A brief history of these compounds is reviewed along with their potential effects and mechanisms of action and the most recent attempts to improve their bioavailability and potency against different types of cancer." | ( Anticancer Potential of Resveratrol, β-Lapachone and Their Analogues. Ferraz da Costa, DC; Ferreira, VF; Ferretti, GDDS; Martins-Dinis, MMDDC; Pereira Rangel, L; Silva, JL, 2020) | 0.56 |
| " Furthermore, data on the interactions of RE when combined with other therapies are still lacking, as well as results related to its absorption and bioavailability in the human body." | ( Potential Adverse Effects of Resveratrol: A Literature Review. Abdel-Rahman, WM; Al-Mohannadi, A; Alhababi, D; Eid, AH; Halabi, S; Hasan, H; Nasrallah, GK; Pintus, G; Posadino, AM; Shaito, A; Younes, N, 2020) | 0.56 |
| " Zein protein may constitute an inexpensive, safe, and effective choice to produce nanoparticles (NPs) to incorporate hydrophobic molecules and overcome the bioavailability issues of RSV." | ( Zein nanoparticles as low-cost, safe, and effective carriers to improve the oral bioavailability of resveratrol. Baião, A; das Neves, J; Monteiro, D; Nunes, R; Sarmento, B, 2020) | 0.56 |
| " This enhanced the therapeutic bioavailability of resveratrol." | ( Enhancement of the cancer inhibitory effect of the bioactive food component resveratrol by nanoparticle based delivery. Ahmed, F; Bano, S; Chaudhary, SC; Khan, F; Samim, M, 2020) | 0.56 |
| " Both RSV and NP-RSV induced significant reductions in tumor growth and the hemoglobin percentages of the tumor mass, but NP-RSV showed greater bioavailability and efficacy than RSV." | ( Resveratrol and Its Nanoformulation Attenuate Growth and the Angiogenesis of Xenograft and Orthotopic Colon Cancer Models. El-Far, AH; Mousa, DS; Mousa, SA; Sudha, T, 2020) | 0.56 |
| " To improve its bioavailability and pharmacological activity, some resveratrol derivatives have been designed and synthesized by substitutions of methoxy, hydroxyl, and other functional groups or heterocyclic esterification either on the "A" or "B" ring, and double bonds were replaced by imine bonds and isometric heterocycles such as naphthyl and imidazole, or synthetic resveratrol oligomers." | ( Synthesis and biological evaluation of resveratrol derivatives with anti-breast cancer activity. Chen, HF; Chen, LM; Gu, JY; Yang, MF; Yang, ZH; Yao, X; Zheng, X; Zheng, ZT, 2020) | 0.56 |
| "In this study, sugary maize dendrimer-like glucan (SMDG) was used as a delivery carrier for improving the bioavailability of resveratrol (RES)." | ( Characterizations and Bioavailability of Dendrimer-like Glucan Nanoparticulate System Containing Resveratrol. Hui, Q; Lu, K; Miao, M; Shi, Y; Ye, F, 2020) | 0.56 |
| " The results also conclude that addressing the bioavailability of resveratrol using it in combination with piperine does not prove more efficacious in preventing lupus-associated pathologies than resveratrol alone." | ( Prophylactic effect of resveratrol and piperine on pristane-induced murine model of lupus-like disease. Bhatnagar, A; Pannu, N, 2020) | 0.56 |
| " The major obstacle posed in most preclinical studies and clinical trials was the low bioavailability of resveratrol." | ( Current Update on Preclinical and Clinical Studies of Resveratrol, a Naturally Occurring Phenolic Compound. Dahiya, R; Dua, K; Gupta, G; Jain, DA; Mishra, A; Samuel, VP, ) | 0.13 |
| " However, unfavorable pharmacokinetics/pharmacodynamics profile such as poor bioavailability restricted its applications." | ( Resveratrol - A comprehensive review of recent advances in anticancer drug design and development. Ahmadi, R; Ebrahimzadeh, MA, 2020) | 0.56 |
| "The possibility of combining the health benefits of kafirin and polyphenols and improving the bioavailability of resveratrol using hollow kafirin nanoparticles via gallic acid crosslinking was investigated." | ( Resveratrol-loaded hollow kafirin nanoparticles via gallic acid crosslinking: An evaluation compared with their solid and non-crosslinked counterparts. Liu, M; Pu, C; Sun, Q; Tang, W; Zhu, Y, 2020) | 0.56 |
| " However, poor bioavailability is a major obstacle for use in clinical cancer treatment." | ( Potential enhancement of host immunity and anti-tumor efficacy of nanoscale curcumin and resveratrol in colorectal cancers by modulated electro- hyperthermia. Chiang, HC; Han, W; Hsieh, PJ; Huang, CC; Ke, CH; Kuo, IM; Lee, JJ; Liao, ATC; Lin, CS; Wang, YS, 2020) | 0.56 |
| " Here, we implanted resveratrol releasing poly(lactide-co-glycolide) scaffolds into epididymal fat to overcome its poor bioavailability with the goal of enhancing local lipid catabolism." | ( Modulation of adipocyte size and fat pad weight via resveratrol releasing scaffolds implanted into the epididymal adipose tissue. Carter, GJ; Gower, RM; Hall, HE; Hendley, MA; Isely, C; Murphy, KP; Patterson, AT, 2021) | 0.62 |
| "Numerous studies document an increased production of reactive oxygen species (ROS) with a subsequent decrease in nitric oxide (NO) bioavailability in different cardiovascular diseases, including hypertension, atherosclerosis, and heart failure." | ( Therapeutic Potential of Polyphenols-Loaded Polymeric Nanoparticles in Cardiovascular System. Cebova, M; Dayar, E; Pechanova, O, 2020) | 0.56 |
| " Resveratrol is a widely recognized activator of Sirt1; however, poor bioavailability and rapid metabolism limit effective clinical translation of promising animal data." | ( Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span. Zemel, MB, 2020) | 0.56 |
| " Our prior murine modeling research observed enhanced resveratrol bioavailability with piperine co-administration." | ( A randomized, double-blind, dose-ranging, pilot trial of piperine with resveratrol on the effects on serum levels of resveratrol. Ahmad, N; Bailey, HH; Havinghurst, T; Johnson, JJ; Kim, K; Lozar, T; Scarlett, CO; Wollmer, BW, 2021) | 0.62 |
| " Furthermore, developed RC-Gel was evaluated for its topical application using skin irritancy, toxicity, and in vivo local bioavailability studies." | ( Formulation and Evaluation of Resveratrol Loaded Cubosomal Nanoformulation for Topical Delivery. Jagwani, S; Jalalpure, S; Kurangi, B, 2021) | 0.62 |
| " In vivo local bioavailability study depicted the good potential of RC-Gel for skin localization." | ( Formulation and Evaluation of Resveratrol Loaded Cubosomal Nanoformulation for Topical Delivery. Jagwani, S; Jalalpure, S; Kurangi, B, 2021) | 0.62 |
| "In this study, the resveratrol was nano-encapsulated in three different sources of starch like Water chestnut Horse chestnut and Lotus stem to safeguard it from gastric conditions and to improve its bioavailability and bioactivity upon digestion." | ( Ultrasonicated resveratrol loaded starch nanocapsules: Characterization, bioactivity and release behaviour under in-vitro digestion. Ahmad, M; Gani, A, 2021) | 0.62 |
| " As synergistic agents in combination with clinically established anticancer drugs, the enhanced anticancer activity at reduced chemotherapy-associated toxicity towards normal organs can be explained by improved pharmacokinetics, pharmacodynamics, bioavailability and metabolism." | ( Chemotherapeutic efficacy of curcumin and resveratrol against cancer: Chemoprevention, chemoprotection, drug synergism and clinical pharmacokinetics. Behera, C; Bhutia, SK; Efferth, T; Jena, M; Nayak, R; Patra, S; Pradhan, B; Rout, L, 2021) | 0.62 |
| " The purpose of the present study was to propose a drug delivery system to enhance the oral bioavailability of combined quercetin and resveratrol." | ( Enhanced Oral Bioavailability and Improved Biological Activities of a Quercetin/Resveratrol Combination Using a Liquid Self-Microemulsifying Drug Delivery System. Chusri, S; Jaisamut, P; Limsuwan, S; Wanna, S; Wiwattanapatapee, R; Wiwattanawongsa, K, 2021) | 0.62 |
| " We developed a novel encapsulation process based on the cyclization activity of CGTase and applied it to the formation of CA inclusion complexes with resveratrol (RVT), which has limited bioavailability due to its low water solubility." | ( Development of an enzymatic encapsulation process for a cycloamylose inclusion complex with resveratrol. Jeon, SH; Jeong, DW; Jeong, HM; Kim, JS; Lee, Y; Shim, JH; Shin, S; Shin, YJ; Woo, SH, 2021) | 0.62 |
| "Resveratrol is a very promising anti-oxidant drug candidate with low oral bioavailability due to its intrinsic poor water solubility, intestinal efflux and metabolization mechanisms." | ( Third-generation solid dispersion combining Soluplus and poloxamer 407 enhances the oral bioavailability of resveratrol. Araújo, F; Lopes, C; Loureiro, A; Marques, S; Prezotti, F; Sarmento, B; Vasconcelos, T, 2021) | 0.62 |
| " However, its poor oral bioavailability limits its clinical application in ICH." | ( Nanoparticles improved resveratrol brain delivery and its therapeutic efficacy against intracerebral hemorrhage. Cai, J; Chen, T; Chen, X; Duan, L; Gao, L; Liu, Q; Liu, W; Lo, PC; Mo, Y; Su, S; Wang, Q; Yang, C; Yang, Y; Zhang, Y; Zhou, L, 2021) | 0.62 |
| " Despite the promising effects observed in different cancer types in in vitro studies, the clinical translation still presents strong limitations due to the low bioavailability of resveratrol." | ( Resveratrol as Chemosensitizer Agent: State of Art and Future Perspectives. Berretta, M; Cocetta, V; Fiorica, F; Montopoli, M; Quagliariello, V, 2021) | 0.62 |
| " Such information is necessary for dose selection and is particularly important given the low bioavailability of resveratrol." | ( Distribution and metabolism of [14C]-resveratrol in human prostate tissue after oral administration of a "dietary-achievable" or "pharmacological" dose: what are the implications for anticancer activity? Britton, RG; Brown, K; Cai, H; Khan, M; Malfatti, M; Ognibene, TJ; Parrott, E; Scott, EN; Steward, WP, 2021) | 0.62 |
| "Despite widespread interest in chemoprevention and therapy due to the high margin of safety of dietary natural compounds, clinical intervention with single agents has failed to yield the expected outcomes, mostly due to poor bioavailability and low potency." | ( Combination of resveratrol and green tea epigallocatechin gallate induces synergistic apoptosis and inhibits tumor growth Amin, ARMR; Chen, ZG; Lamichhane, R; Nannapaneni, S; Shin, DM; Wang, D, 2021) | 0.62 |
| " Thus, RSV may be useful for the treatment of specific thyroid disorders, provided that strategies with improved oral bioavailability of RSV are applied." | ( Resveratrol Alleviates the Inhibitory Effect of Tunicamycin-Induced Endoplasmic Reticulum Stress on Expression of Genes Involved in Thyroid Hormone Synthesis in FRTL-5 Thyrocytes. Eder, K; Ringseis, R; Wen, G, 2021) | 0.62 |
| " In the interim, the most promising approach is to enhance the bioavailability of resveratrol with new formulations." | ( Resveratrol for cancer therapy: Challenges and future perspectives. Ding, L; Goh, BC; Ho, PC; Kwah, MX; Liu, C; Ma, Z; Ong, PS; Ren, B; Shanmugam, MK; Wang, L; Xiang, X, 2021) | 0.62 |
| " Good bioavailability of resveratrol is not reflected in its high biological activity in vivo because of resveratrol isomerization and its poor solubility in aqueous solutions." | ( Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability. Ćirković Veličković, T; Gligorijević, N; Khulal, U; Nedić, O; Radomirović, M; Stanić-Vučinić, D; Stojadinović, M, 2021) | 0.62 |
| " These derivatives contain a monosubstituted aromatic ring that could mimic the RSV phenolic nucleus and a longer flexible chain that could confer a better stability and bioavailability than RSV." | ( A Phenylacetamide Resveratrol Derivative Exerts Inhibitory Effects on Breast Cancer Cell Growth. Avena, P; Bonomo, MG; Ceramella, J; Chimento, A; De Luca, A; Iacopetta, D; Infantino, V; Parisi, OI; Pezzi, V; Santarsiero, A; Saturnino, C; Sinicropi, MS, 2021) | 0.62 |
| " However, it exhibits low bioavailability in humans and animals." | ( Resveratrol Butyrate Esters Inhibit BPA-Induced Liver Damage in Male Offspring Rats by Modulating Antioxidant Capacity and Gut Microbiota. Chang, SKC; Chen, YW; Chiu, MH; Hou, CY; Liao, JX; Shih, MK; Tain, YL; Yeh, YT, 2021) | 0.62 |
| " Moreover, the implications of digestion on the putative benefits of dietary PC against COVID-19 are presented by addressing the bioavailability and biotransformation of PC by the gut microbiota." | ( Bioactivity, bioavailability, and gut microbiota transformations of dietary phenolic compounds: implications for COVID-19. Augusti, PR; Bronze, MR; Conterato, GMM; Denardin, CC; Emanuelli, T; Prazeres, ID; Serra, AT, 2021) | 0.62 |
| " The use of resveratrol in clinical practice is limited by the low bioavailability following oral administration, due to the pharmacokinetic and metabolic characteristics of the molecule." | ( Can Resveratrol-Inhaled Formulations Be Considered Potential Adjunct Treatments for COVID-19? Capizzi, A; Mastromarino, P; Rossi, GA; Sacco, O, ) | 0.13 |
| " However, its short half-life and low bioavailability is a major hurdle in its effective use." | ( Development and preclinical evaluation of microneedle-assisted resveratrol loaded nanostructured lipid carriers for localized delivery to breast cancer therapy. Catalina Ardila, D; Gadag, S; Garg, S; Narayan, R; Nayak, AS; Nayak, UY; Nayak, Y; Sant, S, 2021) | 0.62 |
| " However, RSV has met limited success due to its poor oral bioavailability and inefficient systemic delivery." | ( Cyclodextrin based bone regenerative inclusion complex for resveratrol in postmenopausal osteoporosis. Baby, C; Chourasia, MK; Ghate, V; Lewis, S; Narayana Kalkura, S; Nayak, Y; Saklani, R; Shah, A; Shah, AA; Singh, PK, 2021) | 0.62 |
| "08% of their blood concentrations at 1 h, respectively, which indicated that lymphatic transport in the form of JNP has limited advantages in improving the oral bioavailability of Res and αCT." | ( pH-sensitive dual drug loaded janus nanoparticles by oral delivery for multimodal analgesia. Gao, J; Liu, L; Lu, X; Xie, X; Yao, W, 2021) | 0.62 |
| " In order to improve the pH sensitivity and bioavailability of Gal-Res, Gal-Res nanoparticles (Gal-Res NPs) were prepared using polydopamine (PDA) as a drug carrier." | ( Preparation, Characterization, and In Vitro/In Vivo Evaluation of 3-O-β-D-Galactosylated Resveratrol-Loaded Polydopamine Nanoparticles. Chen, W; Dong, Q; Lv, S; Shan, X; Wang, B; Zha, L; Zhang, C, 2021) | 0.62 |
| "09 h, and the bioavailability improved to 140." | ( Sustained-Release Solid Dispersion of High-Melting-Point and Insoluble Resveratrol Prepared through Hot Melt Extrusion to Improve Its Solubility and Bioavailability. Fan, W; Gao, M; Zhang, X; Zhu, W, 2021) | 0.62 |
| " However, it suffers from poor bioavailability because of the low solubility, chemical instability, and hepatic metabolism." | ( Enhanced oral permeability of Trans-Resveratrol using nanocochleates for boosting anticancer efficacy; in-vitro and ex-vivo appraisal. El-Kamel, AH; El-Melegy, MG; Eltaher, HM; Gaballah, A, 2021) | 0.62 |
| " Resveratrol (RES), a natural product with potential antitumor activity against bladder cancer, is associated with rapid metabolism and low bioavailability and needs to be combined with chemotherapeutic drugs to improve its use." | ( Additive effects of resveratrol and doxorubicin on bladder cancer cells. Almeida, TC; da Silva, GN; de Medeiros Teixeira, LF; Lima, APB; Melo, AS; Soares, LBM, 2022) | 0.72 |
| " Resveratrol displays beneficial pharmacological activities; however, low oral bioavailability limits its effectiveness." | ( Synthesis, characterization and evaluation of resveratrol-loaded functionalized carbon nanotubes as a novel delivery system in radiation enteropathy. Ali, HE; Radwan, RR, 2021) | 0.62 |
| " However, the hindrances in their absorption, specificity, and bioavailability can be overcome using nanotechnology." | ( Nanoencapsulation of Polyphenols as Drugs and Supplements for Enhancing Therapeutic Profile - A Review. Ansari, MT; Hafiz, AK; Hasnain, MS; Kalam, N; Khatoon, S; Shaikh, MF, 2022) | 0.72 |
| " In this review, we summarize the existing in vitro, in vivo, and clinical data from published studies addressing the optimization of bioavailability of stilbenoids." | ( Enhancing Bioavailability of Nutraceutically Used Resveratrol and Other Stilbenoids. Baldovska, S; Kolesarova, A; Vesely, O, 2021) | 0.62 |
| "Most drugs or the natural substances reputed to display some biological activity are hydrophobic molecules that demonstrate low bioavailability regardless of their mode of absorption." | ( Resveratrol and cyclodextrins, an easy alliance: Applications in nanomedicine, green chemistry and biotechnology. Batiha, GE; Bru, R; Clément, C; Jacquard, C; Jeandet, P; Khan, H; Khayatkashani, M; Matencio, A; Morkunas, I; Nabavi, SF; Nabavi, SM; Sobarzo-Sánchez, E; Trotta, F; Uddin, MS, 2021) | 0.62 |
| "The development of protein-based nanocarriers to improve the water solubility, stability, and bioavailability of hydrophobic or poorly soluble bioactive molecules has attracted increasing interest in the food and pharmaceutical industries." | ( Sodium Dodecyl Sulfate-Dependent Disassembly and Reassembly of Soybean Lipophilic Protein Nanoparticles: An Environmentally Friendly Nanocarrier for Resveratrol. Li, Y; Qi, B; Song, H; Sun, Y; Zhang, S; Zhong, M, 2022) | 0.72 |
| " To address the low bioavailability of resveratrol, we investigated a novel oral formulation of resveratrol, JOTROL™, that has shown increased pharmacokinetic properties compared to non-formulated resveratrol in animals and in humans." | ( JOTROL, a Novel Formulation of Resveratrol, Shows Beneficial Effects in the 3xTg-AD Mouse Model. Brothers, SP; Dennison, JL; Gravel, E; Hammond-Vignini, S; Hayward, MA; Ke, D; Li, Z; Lohse, I; Modarresi, F; Timmons, JA; Volmar, CH; Wahlestedt, C; Wang, J, 2022) | 0.72 |
| "JOTROL displays significantly increased bioavailability over non-formulated resveratrol." | ( JOTROL, a Novel Formulation of Resveratrol, Shows Beneficial Effects in the 3xTg-AD Mouse Model. Brothers, SP; Dennison, JL; Gravel, E; Hammond-Vignini, S; Hayward, MA; Ke, D; Li, Z; Lohse, I; Modarresi, F; Timmons, JA; Volmar, CH; Wahlestedt, C; Wang, J, 2022) | 0.72 |
| " Unfortunately, its biological benefits are limited by its low bioavailability and rapid hepatic metabolism and degradation in the body." | ( Evaluation of novel conjugated resveratrol polymeric nanoparticles in reduction of plasma degradation, hepatic metabolism and its augmentation of anticancer activity in vitro and in vivo. Benson, HAE; Chen, Y; Dass, CR; Yee, YJ, 2022) | 0.72 |
| " Nanoformulations can bring a major improvement in the bioavailability of resveratrol but still the formulation still suffers with pharmacokinetics issues clinically." | ( The science of resveratrol, formulation, pharmacokinetic barriers and its chemotherapeutic potential. Badgujar, V; Khan, A; Majeed, S; Murtuja, S; Robertson, I; Sajid Ali, M; Sami, F; Saquib Hasnain, M; Tahir Ansari, M; Wai Hau, T, 2022) | 0.72 |
| " Milk EXOs enhanced the bioavailability and anticancer activity of CUR and RSV by acting as Trojan horses that escape from cancer cells’ ABC-mediated chemoresistance." | ( Milk-Derived Exosomes as Nanocarriers to Deliver Curcumin and Resveratrol in Breast Tissue and Enhance Their Anticancer Activity. Cattivelli, A; Cortés-Martín, A; Dávalos, A; Del Pozo-Acebo, L; Del Saz, A; Espín, JC; González-Sarrías, A; Iglesias-Aguirre, CE; López de Las Hazas, MC; Vallejo, F, 2022) | 0.72 |
| " Although bioavailability studies have shown poor absorption and high metabolism of this stilbene, multiple studies demonstrated its biological properties." | ( In the shadow of resveratrol: biological activities of epsilon-viniferin. Atgié, C; Beaumont, P; Courtois, A; Krisa, S; Richard, T, 2022) | 0.72 |
| " However, the low bioavailability of resveratrol and the difficulty of reaching the targeted location in the brain reduce its efficacy considerably." | ( Resveratrol-Loaded Glutathione-Coated Collagen Nanoparticles Attenuate Acute Seizures by Inhibiting HMGB1 and TLR-4 in the Hippocampus of Mice. Aggarwal, NB; Akhter, J; Arora, I; Asad, M; Hoda, U; Rastogi, S; Samim, M; Siddiqui, MA, 2022) | 0.72 |
| " However, its poor bioavailability in the brain represents a challenge for its application in PD treatment." | ( Enhancement of blood-brain barrier penetration and the neuroprotective effect of resveratrol. Bhurtel, S; Choi, DY; Duwa, R; Jeong, JH; Katila, N; Khanal, S; Lee, S; Maharjan, S; Yook, S, 2022) | 0.72 |
| " Antioxidants' bioavailability has become one of the main research topics in bio-nanomedicine." | ( Plant-Derived Nanoscale-Encapsulated Antioxidants for Oral and Topical Uses: A Brief Review. Kim, SH; Lee, YC, 2022) | 0.72 |
| " Encapsulation of these chemotherapeutics inside nanoparticles significantly improves the bioavailability and half-life of drugs, while increasing their tumor penetration and localization." | ( Fully Natural Lecithin Encapsulated Nano-Resveratrol for Anti-Cancer Therapy. Guo, M; Liang, M; Saw, PE; Yao, Y, 2022) | 0.72 |
| " However, strategies to favorably influence the poor bioavailability of RESV would be helpful." | ( Resveratrol Attenuates Mast Cell Mediated Allergic Reactions: Potential for Use as a Nutraceutical in Allergic Diseases? Bilotta, S; Civelek, M; Lorentz, A, 2022) | 0.72 |
| " Although there have been several preclinical and clinical investigations of resveratrol, the contributions of gut phase-II metabolism and enterohepatic circulation to the oral bioavailability and pharmacokinetics of resveratrol remain unclear." | ( Impact of route-dependent phase-II gut metabolism and enterohepatic circulation on the bioavailability and systemic disposition of resveratrol in rats and humans: A comprehensive whole body physiologically-based pharmacokinetic modeling. Choi, E; Han, DG; Jung, Y; Kim, MS; Seo, SW; Yoo, JW; Yoon, IS, 2022) | 0.72 |
| " However, due to the poor bioavailability of RSV, the mechanisms of RSV against inflammation in obesity models remain unclear." | ( Protective Effects of Dietary Resveratrol against Chronic Low-Grade Inflammation Mediated through the Gut Microbiota in High-Fat Diet Mice. Chen, F; Hu, X; Ma, Y; Wang, D; Wang, P; Zhao, W; Zhao, X, 2022) | 0.72 |
| "Children and adult with sickle cell disease (SCD) display priapism associated with low nitric oxide (NO) bioavailability and oxidative stress in penis." | ( Resveratrol-nitric oxide donor hybrid effect on priapism in sickle cell and nitric oxide-deficient mouse. Alexandre, EC; Burnett, AL; Calmasini, FB; Costa, FF; Dos Santos, JL; Pereira, DA; Pinheiro, AK; Reis, LO; Silva, FH, 2022) | 0.72 |
| "Treatment with RVT-FxMe reversed the enhanced NO-cGMP-mediated CC relaxations in eNOS-/- mice, but not in SCD mice; it is likely that excess of plasma hemoglobin in SCD mice act to inactivate NO before it reaches soluble guanylyl cyclase, avoiding restoration of NO bioavailability in penis." | ( Resveratrol-nitric oxide donor hybrid effect on priapism in sickle cell and nitric oxide-deficient mouse. Alexandre, EC; Burnett, AL; Calmasini, FB; Costa, FF; Dos Santos, JL; Pereira, DA; Pinheiro, AK; Reis, LO; Silva, FH, 2022) | 0.72 |
| " Further analyses have verified the indispensable role of MSNs in improving the bioavailability of RSV, which could result in a more favorable therapeutic efficacy in DP related to regulating the polarization of the macrophage." | ( Grafting resveratrol onto mesoporous silica nanoparticles towards efficient sustainable immunoregulation and insulin resistance alleviation for diabetic periodontitis therapy. Bao, C; Feng, J; Tan, Y; Xiao, Y, 2022) | 0.72 |
| " Although phytochemicals have the potential ability to reduce the risk of CVD, the big gap between required high concentration in cells and the low bioavailability in the blood of phytochemicals compromise their therapeutic potentials." | ( Synergistic anti-inflammatory effects and mechanisms of the combination of resveratrol and curcumin in human vascular endothelial cells and rodent aorta. Si, H; Wang, X; Zhang, L, 2022) | 0.72 |
| " Coadministration of RES and LUT could significantly improve the bioavailability of LUT and increase the systemic exposure to RES, and the combined treatment could also benefit from their multi-component and multi-target characteristics." | ( Combination of resveratrol and luteolin ameliorates α-naphthylisothiocyanate-induced cholestasis by regulating the bile acid homeostasis and suppressing oxidative stress. Li, K; Ran, X; Wang, W; Wei, X; Wu, W; Xu, X; Zhang, T; Zhang, Y, 2022) | 0.72 |
| " To improve the bioavailability and pharmacokinetic properties of RSV, efforts are being made to produce efficient formulations accompanying efficient drug delivery strategies." | ( Role of Drug Delivery System in Improving the Bioavailability of Resveratrol. Hamid Akash, MS; Rehman, K; Saleem, Z, 2022) | 0.72 |
| " These HCC-targeted NPs led to a significant reduction in the drug dosage, delayed the rate of drug release and improved the bioavailability of the encapsulated drugs." | ( Curcumin- and resveratrol-co-loaded nanoparticles in synergistic treatment of hepatocellular carcinoma. Jia, R; Li, J; Qian, Y; Tian, X; Zheng, Y, 2022) | 0.72 |
| " However, R bioavailability and pharmacokinetics are still problematic under oral supplementation." | ( Resveratrol Effects on the Reproductive System in Ovariectomized Rats: Deciphering Possible Mechanisms. Doroshenko, A; Falalyeyeva, T; Kobyliak, N; Sinitsyna, O; Stryga, O; Sulaieva, O; Zaychenko, G, 2022) | 0.72 |
| "Resveratrol (RES), a polyphenol with strong antioxidant capacity but poor bioavailability and light instability, urgently needs an effective delivery technique to overcome its drawbacks." | ( Structural degradation and uptake of resveratrol-encapsulated liposomes using an in vitro digestion combined with Caco-2 cell absorption model. Deng, L; Han, J; Huang, L; Jiang, H; Liu, W; Tian, M; Xu, X; Zhen, C, 2023) | 0.91 |
| " Indeed, due to its higher bioavailability paired with reduced toxicity compared to other stilbenes, PTS has become an attractive drug candidate for the treatment of several disease conditions, including diabetes, cancer, cardiovascular disease, neurodegenerative disorders, and aging." | ( New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects. Ganesan, K; Mohandas, S; Nagarajan, S; Ramkumar, KM; Xu, B, 2022) | 0.72 |
| "Resveratrol and Gefitinib are adjunct therapies for various cancers; however, both have been limited by low solubility, low cellular uptake, and bioavailability issues." | ( A novel RP-HPLC method development and validation for simultaneous quantification of gefitinib and resveratrol in polymeric hybrid lipid nanoparticles and glioma cells. Ghazwani, M; Gowda, DV; Gurupadayya, BM; Hani, U; Hemanth Vikram, PR; Osmani, RAM; Sathishbabu, P; Shakeela, C, 2022) | 0.72 |
| " The laboratory data and clinical trials have demonstrated that the bioavailability and bioactivity of curcumin are influenced by the feature of the curcumin molecular complex types." | ( Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin. Avram, A; Barbu, I; Mocanu, A; Pop, LC; Racz, CP; Racz, LZ; Roman, I; Sárközi, M; Toma, VA; Tomoaia, G; Tomoaia-Cotisel, M, 2022) | 0.72 |
| "Resveratrol (Res) is a non-flavonoid polyphenol compound with biological pleiotropic properties, but low bioavailability limits its application value." | ( Radial Extracorporeal Shock Wave Therapy Combined with Resveratrol Derivative Alleviates Chronic Nonbacterial Prostatitis in Rats. Bian, Z; Jin, C; Liang, C; Song, Z, 2023) | 0.91 |
| " However, its low bioavailability and short half-life have restricted its use." | ( Design, development and evaluation of Resveratrol transdermal patches for breast cancer therapy. Gadag, S; Garg, S; Narayan, R; Nayak, UY; Nayak, Y, 2023) | 0.91 |
| " Moreover, aerosolized administration of polypeptide complexes demonstrates excellent bioavailability and inhibition of immediate hypersensitivity reactions in ear tissue in vivo." | ( Development of a Water-Dispersible Supramolecular Complex of Polyphenol with Polypeptides for Attenuation of the Allergic Response using a Mechanochemical Strategy. Hino, S; Ikeda, A; Kawamoto, S; Kawamura, S; Kawasaki, R; Kodama, T; Maeda, A; Miyaki, S; Nishimura, T; Ozawa, N; Yamana, K; Yimiti, D, 2023) | 0.91 |
| " In vitro digestion experiments showed that the RES bioavailability of SPI-PG-RES was much higher than that of free RES and SPI-RES." | ( Soy protein isolate-polyguluronate nanoparticles loaded with resveratrol for effective treatment of colitis. Bi, D; Cao, J; Hu, Z; Li, M; Li, W; Wu, Y; Xu, H; Xu, X; Yang, P; Yao, L; Yi, J, 2023) | 0.91 |
| " We previously utilized butyrate in order to improve the bioavailability of resveratrol via esterification and generated a resveratrol butyrate monoester (RBM)." | ( Dietary Resveratrol Butyrate Monoester Supplement Improves Hypertension and Kidney Dysfunction in a Young Rat Chronic Kidney Disease Model. Chang, CI; Chang-Chien, GP; Hou, CY; Hsu, CN; Lin, S; Tain, YL, 2023) | 0.91 |
| " Compared with REV, RBE exhibits higher bioavailability and better antioxidant effects." | ( Resveratrol Butyrate Ester Supplementation Blunts the Development of Offspring Hypertension in a Maternal Di-2-ethylhexyl Phthalate Exposure Rat Model. Chang-Chien, GP; Hou, CY; Hsu, CN; Lin, S; Tain, YL, 2023) | 0.91 |
| "This study examined the influence of the nanoliposomes (LPs) particle size on the solubility, antioxidant stability, in vitro release profile, Caco-2 cellular transport activity, cellular antioxidant activity, and in vivo oral bioavailability of resveratrol (RSV)." | ( Encapsulation of resveratrol within size-controlled nanoliposomes: Impact on solubility, stability, cellular permeability, and oral bioavailability. Baek, Y; Jeong, EW; Lee, HG, 2023) | 0.91 |
| " This review also emphasizes the significance of the co-delivery vehicles-based nanoparticles of such bioactive phytochemicals that could improve their bioavailability and reduce their systemic dose." | ( Co-administration of curcumin with other phytochemicals improves anticancer activity by regulating multiple molecular targets. Asoodeh, A; Ghobadi, N, 2023) | 0.91 |
| " This antioxidant compound, however, barely crosses the blood-brain barrier (BBB), thereby limiting its bioavailability and stability at the target sites in the brain." | ( Brain targeting based nanocarriers loaded with resveratrol in Alzheimer's disease: A review. Bahrehmand, F; Fakhri, S; Gholami, M; Jalili, C; Kakebaraei, S; Kakehbaraei, S; Kiani, A, 2023) | 0.91 |
| " One of the main problems in clinical research is related to the limited bioavailability of most polyphenols." | ( Combination Chemotherapy with Selected Polyphenols in Preclinical and Clinical Studies-An Update Overview. Barbarić, M; Jakobušić Brala, C; Karković Marković, A; Kugić, A; Torić, J, 2023) | 0.91 |
| ", are front runners as drug candidates due to their diverse effects from different functional groups that affect bioavailability and molecular interactions." | ( Stilbenes, a Versatile Class of Natural Metabolites for Inflammation-An Overview. Al-Khayri, JM; Al-Mssallem, MQ; Alessa, FM; Almaghasla, MI; Gowda, Y; Harish, HM; Lakshmaiah, VV; Mascarenhas, R; Nagella, P; Rezk, AA, 2023) | 0.91 |
| "This paper aimed to improve in vitro dissolution/solubility as well as inhibit intestinal metabolism and thus enhance oral bioavailability for a BDDCS class II drug by constructing surfactant-based amorphous solid dispersions using resveratrol (RES) as a model drug." | ( Use of surfactant-based amorphous solid dispersions for BDDCS class II drugs to enhance oral bioavailability: A case report of resveratrol. Chen, J; Cheng, H; Cheng, J; Cui, X; Fu, T; Jia, X; Ke, Y; Li, J; Li, W; Pan, X; Qiao, H; Zou, L, 2023) | 0.91 |
| " But it has become challenging to determine the optimal dose, time and duration of RES and improve the bioavailability of RES, which many researchers need to overcome." | ( Does resveratrol improve cognition in humans? A scientometric study to an in-depth review. Fan, X; Song, M; Tu, W, 2023) | 0.91 |
| " However, poor oral bioavailability is the major hurdle to its clinical use." | ( Formulation of Resveratrol-Loaded Polycaprolactone Inhalable Microspheres Using Tween 80 as an Emulsifier: Factorial Design and Optimization. Chakraborty, A; Mahar, R; Nainwal, N, 2023) | 0.91 |
| "Resveratrol (RES) is a common active factor in the functional food field, but poor water solubility and low bioavailability have limited its application." | ( Nanoparticles prepared by polysaccharides extracted from Biyang floral mushroom loaded with resveratrol: Characterization, bioactivity and release behavior under in vitro digestion. Hao, L; Liu, K; Liu, X; Liu, Y; Lu, J; Yi, J, 2023) | 0.91 |
| " To overcome this challenge, multiple research groups have investigated the synthesis of new resveratrol derivatives to enhance bioavailability and pharmacological activities." | ( Synthesis and Biological Evaluation of Resveratrol Methoxy Derivatives. Fragopoulou, E; Gioti, K; Gkotsi, K; Kalampaliki, AD; Kostakis, IK; Lambrinidis, G; Petsini, F; Tenta, R, 2023) | 0.91 |
| " This study provides new knowledge about key molecular mechanisms involved in QUE-mediated protection against AFB1 toxicity and encourages in vivo studies to assess QUE's bioavailability and beneficial effects on aflatoxicosis." | ( Discovering the Protective Effects of Quercetin on Aflatoxin B1-Induced Toxicity in Bovine Foetal Hepatocyte-Derived Cells (BFH12). Barbarossa, A; Bardhi, A; Bassan, I; Dacasto, M; Giantin, M; Montanucci, L; Pauletto, M; Tolosi, R; Zaghini, A, 2023) | 0.91 |
| " Resveratrol (RSV) is widely proven to guard mitochondria, yet the unsatisfactory bioavailability restricts its clinical application." | ( A Mitochondrial Nanoguard Modulates Redox Homeostasis and Bioenergy Metabolism in Diabetic Peripheral Neuropathy. Cai, X; Gao, S; Gao, Y; Huang, H; Lei, X; Lin, Y; Shi, S; Wang, Y; Yao, Y; Zhang, G; Zhao, Y, 2023) | 0.91 |
| " This innovative oral delivery strategy capitalizes on the advantageous properties of polysaccharide hydrogel and CDF to augment bioavailability of phytochemicals, laying the groundwork for developing novel oral interventions employing natural phytochemicals to address intestinal-related diseases." | ( Efficient oral delivery of resveratrol-loaded cyclodextrin-metal organic framework for alleviation of ulcerative colitis. Chen, L; Chen, T; Hu, J; Hua, Z; Li, Y; Luo, F; Wu, D; Xu, Y; Zhao, R, 2023) | 0.91 |
| "The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs." | ( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019) | 0.51 |
Resveratrol, a polyphenol found in red wine, can enhance FMD acutely. We investigated whether there is a dose-response relationship for this effect. To achieve an equivalent effect, a 10-fold dosage of genistein was required. This highlights the dose advantage of resver atrol, as poor bioavailability is a common concern.
| Product Category | Products |
|---|---|
| Other | 1 |
| Vitamins & Supplements | 12 |
| Beauty & Personal Care | 25 |
| Professional Supplements | 9 |
| Active Lifestyle & Fitness | 1 |
| Role | Description |
|---|---|
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| antioxidant | A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. |
| phytoalexin | A toxin made by a plant that acts against an organism attacking it. |
| radical scavenger | A role played by a substance that can react readily with, and thereby eliminate, radicals. |
| quorum sensing inhibitor | Any compound that interferes with bacterial communication (quorum sensing, QS). |
| phytoalexin | A toxin made by a plant that acts against an organism attacking it. |
| antioxidant | A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. |
| glioma-associated oncogene inhibitor | An inhibitor of any of the glioma-associated oncogene (GLI) proteins. |
| geroprotector | Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| resveratrol | A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups. |
| stilbenol | Any stilbenoid with at least one phenolic group. |
| polyphenol | Members of the class of phenols that contain 2 or more benzene rings each of which is substituted by at least one hydroxy group. |
| resorcinols | Any benzenediol in which the two hydroxy groups are meta to one another. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Pathway | Proteins | Compounds |
|---|---|---|
| Metabolism | 1496 | 1108 |
| Biological oxidations | 150 | 276 |
| Phase I - Functionalization of compounds | 69 | 175 |
| pterostilbene biosynthesis | 1 | 6 |
| resveratrol biosynthesis | 0 | 9 |
| resveratrol degradation | 0 | 4 |
| ATP biosynthesis | 40 | 15 |
| resveratrol biosynthesis | 1 | 11 |
| Resveratrol biosynthesis | 1 | 6 |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 35.4813 | 0.0032 | 45.4673 | 12,589.2998 | AID2517 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 44.6684 | 0.0447 | 17.8581 | 100.0000 | AID485294 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 34.3521 | 0.0251 | 20.2376 | 39.8107 | AID886; AID893 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 34.3521 | 0.0251 | 20.2376 | 39.8107 | AID886; AID893 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 29.7349 | 0.1778 | 14.3909 | 39.8107 | AID2147 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 2.9867 | 0.0072 | 15.7588 | 89.3584 | AID1224835; AID411; AID588342 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 28.1838 | 0.0184 | 6.8060 | 14.1254 | AID624417 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 20.5178 | 0.1000 | 20.8793 | 79.4328 | AID488773; AID588453 |
| BRCA1 | Homo sapiens (human) | Potency | 12.5893 | 0.8913 | 7.7225 | 25.1189 | AID624202 |
| ClpP | Bacillus subtilis | Potency | 25.1189 | 1.9953 | 22.6730 | 39.8107 | AID651965 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 2.1208 | 0.0060 | 38.0041 | 19,952.5996 | AID1159521; AID1159523 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 10.6822 | 0.1737 | 34.3047 | 61.8120 | AID1346859 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 7.0272 | 0.0041 | 10.8903 | 31.5287 | AID493106; AID493107; AID504466; AID504467 |
| GLS protein | Homo sapiens (human) | Potency | 5.0119 | 0.3548 | 7.9355 | 39.8107 | AID624146 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 10.6822 | 0.1737 | 34.3047 | 61.8120 | AID1346859 |
| TDP1 protein | Homo sapiens (human) | Potency | 12.7916 | 0.0008 | 11.3822 | 44.6684 | AID686978; AID686979 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 16.1062 | 0.0007 | 14.5928 | 83.7951 | AID1259369; AID1259392 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 11.2664 | 0.1800 | 13.5574 | 39.8107 | AID1460; AID1468 |
| AR protein | Homo sapiens (human) | Potency | 8.0041 | 0.0002 | 21.2231 | 8,912.5098 | AID1259243; AID1259247; AID1259381; AID588515; AID588516; AID743035; AID743036; AID743040; AID743042; AID743054; AID743063 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 3.0560 | 0.0133 | 26.9810 | 70.7614 | AID1346978 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 33.8225 | 0.0112 | 12.4002 | 100.0000 | AID1030 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 10.0000 | 0.0013 | 7.7625 | 44.6684 | AID914; AID915 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 9.8486 | 0.0006 | 57.9133 | 22,387.1992 | AID1259377; AID1259378; AID1259394 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 23.4978 | 0.0010 | 22.6508 | 76.6163 | AID1224838; AID1224839; AID1224893 |
| progesterone receptor | Homo sapiens (human) | Potency | 22.5542 | 0.0004 | 17.9460 | 75.1148 | AID1346784; AID1346795 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 15.0030 | 0.5318 | 15.4358 | 37.6858 | AID504845 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 9.5114 | 0.0123 | 7.9835 | 43.2770 | AID1346984; AID1645841 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 16.0784 | 0.0002 | 14.3764 | 60.0339 | AID588533; AID720692 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 32.1783 | 0.0030 | 41.6115 | 22,387.1992 | AID1159552; AID1159553; AID1159555 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 27.7852 | 0.0008 | 17.5051 | 59.3239 | AID1159527 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 5.9983 | 0.0015 | 30.6073 | 15,848.9004 | AID1224819; AID1224820; AID1224821; AID1224823; AID1224841; AID1224842; AID1224848; AID1224849; AID1259401; AID1259403 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 21.9547 | 0.3758 | 27.4851 | 61.6524 | AID743217 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 30.8341 | 0.0054 | 28.0263 | 1,258.9301 | AID1346982; AID1346985; AID720659 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 21.2883 | 0.0002 | 29.3054 | 16,493.5996 | AID1259244; AID1259248; AID1259383; AID588513; AID588514; AID743069; AID743075; AID743077; AID743078; AID743079; AID743080; AID743091 |
| G | Vesicular stomatitis virus | Potency | 9.7717 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 15.4871 | 0.0010 | 8.3798 | 61.1304 | AID1645840 |
| 67.9K protein | Vaccinia virus | Potency | 28.1838 | 0.0001 | 8.4406 | 100.0000 | AID720579 |
| Parkin | Homo sapiens (human) | Potency | 1.1582 | 0.8199 | 14.8306 | 44.6684 | AID720573 |
| P53 | Homo sapiens (human) | Potency | 50.1187 | 0.0731 | 9.6858 | 31.6228 | AID504706 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 31.2843 | 0.0010 | 24.5048 | 61.6448 | AID588534; AID588535; AID743212; AID743215 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 22.2725 | 0.0010 | 19.4141 | 70.9645 | AID588536; AID588537; AID743191 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 3.0899 | 0.0237 | 23.2282 | 63.5986 | AID743222 |
| arylsulfatase A | Homo sapiens (human) | Potency | 0.3793 | 1.0691 | 13.9551 | 37.9330 | AID720538 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 17.7828 | 0.3981 | 13.7447 | 31.6228 | AID1721; AID1722 |
| caspase-3 | Homo sapiens (human) | Potency | 3.0560 | 0.0133 | 26.9810 | 70.7614 | AID1346978 |
| IDH1 | Homo sapiens (human) | Potency | 32.6427 | 0.0052 | 10.8652 | 35.4813 | AID686970 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 7.9433 | 0.0355 | 20.9770 | 89.1251 | AID504332 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 0.6489 | 0.0165 | 25.3078 | 41.3999 | AID504836; AID602332 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 10.3758 | 0.0007 | 23.0674 | 1,258.9301 | AID651777; AID743085; AID743122 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 2.6087 | 0.0017 | 23.8393 | 78.1014 | AID743083 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 61.6905 | 0.0016 | 28.0151 | 77.1139 | AID1259385 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 42.2940 | 0.0391 | 47.5451 | 146.8240 | AID1224845; AID1224896 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 50.1187 | 0.5406 | 17.6392 | 96.1227 | AID2364; AID2528 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 39.5068 | 0.0366 | 19.6376 | 50.1187 | AID2100 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 22.3872 | 2.5119 | 13.8003 | 28.1838 | AID743205 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 11.9899 | 0.0126 | 2.4518 | 25.0177 | AID485313 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 42.5615 | 23.9341 | 23.9341 | 23.9341 | AID1967 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 8.7699 | 0.3162 | 12.4435 | 31.6228 | AID902; AID924 |
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 21.1972 | 0.0018 | 15.6638 | 39.8107 | AID894 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 0.0000 | 0.0060 | 26.1688 | 89.1251 | AID488953 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 112.2020 | 0.0100 | 39.5371 | 1,122.0200 | AID1479 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 3.9811 | 3.5481 | 19.5427 | 44.6684 | AID743266 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 29.7909 | 0.0003 | 23.4451 | 159.6830 | AID743065; AID743067 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 2.0396 | 0.0376 | 17.0823 | 61.1927 | AID1259364; AID1259388 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 22.3872 | 2.5119 | 13.8003 | 28.1838 | AID743205 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 2.2387 | 0.0006 | 18.4198 | 1,122.0200 | AID2669 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 44.6684 | 0.0224 | 21.0102 | 89.1251 | AID485314 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 20.7491 | 0.0066 | 9.8094 | 18.4927 | AID1347050 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 16.5370 | 0.0002 | 2.6215 | 31.4954 | AID485297 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 11.0913 | 0.0037 | 8.6189 | 23.2809 | AID2667; AID2668 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 17.3172 | 0.0006 | 27.2152 | 1,122.0200 | AID651741; AID720636; AID743202; AID743219 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 44.6684 | 0.0501 | 27.0736 | 89.1251 | AID588590 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 13.5293 | 0.1585 | 5.2879 | 12.5893 | AID493164; AID540303 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 13.5293 | 0.1585 | 5.2879 | 12.5893 | AID493164; AID540303 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 13.5293 | 0.1585 | 5.2879 | 12.5893 | AID493164; AID540303 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 11.3026 | 0.0079 | 8.2332 | 1,122.0200 | AID2546; AID2551; AID2762; AID2763 |
| geminin | Homo sapiens (human) | Potency | 23.5304 | 0.0046 | 11.3741 | 33.4983 | AID493164; AID624296 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 14.1254 | 0.0316 | 22.3146 | 100.0000 | AID588579 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 17.7771 | 0.1259 | 12.2344 | 35.4813 | AID1458 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 3.9811 | 0.0316 | 10.2792 | 39.8107 | AID884; AID885 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 0.1585 | 0.1778 | 24.7352 | 79.4328 | AID488949 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 0.0041 | 9.9625 | 28.1838 | AID2675 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 16.0252 | 0.8913 | 12.0676 | 28.1838 | AID1459; AID1487 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 19.9526 | 0.3162 | 12.7657 | 31.6228 | AID881 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 31.0994 | 0.0015 | 57.7890 | 15,848.9004 | AID1259244 |
| Interferon beta | Homo sapiens (human) | Potency | 9.7717 | 0.0033 | 9.1582 | 39.8107 | AID1645842 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 9.7717 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 49.9749 | 0.0023 | 19.5956 | 74.0614 | AID651631; AID720552 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 10.0000 | 0.3162 | 11.4157 | 31.6228 | AID924 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 10.0000 | 0.3162 | 11.4157 | 31.6228 | AID924 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 31.0994 | 0.0015 | 51.7393 | 15,848.9004 | AID1259244 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Endothelin receptor type B | Rattus norvegicus (Norway rat) | Potency | 17.7828 | 0.5623 | 15.1609 | 31.6228 | AID1721 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Endothelin-1 receptor | Rattus norvegicus (Norway rat) | Potency | 17.7828 | 0.5623 | 15.1609 | 31.6228 | AID1721 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 19.9526 | 0.0063 | 8.2350 | 39.8107 | AID881 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 3.6898 | 0.0037 | 8.1081 | 23.2809 | AID2667 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 2.3710 | 0.0266 | 22.4482 | 66.8242 | AID651802 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1.0000 | 10.4756 | 28.1838 | AID1457 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 19.9526 | 3.9811 | 46.7448 | 112.2020 | AID720708 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 9.7717 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 2.9751 | 0.0119 | 17.9420 | 71.5630 | AID651632; AID720516 |
| Ataxin-2 | Homo sapiens (human) | Potency | 3.5931 | 0.0119 | 12.2221 | 68.7989 | AID588378; AID651632 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 9.7717 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 9.5283 | 0.0601 | 10.7453 | 37.9330 | AID485368 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 16.7364 | 0.0013 | 10.1577 | 42.8575 | AID1259252; AID1259253; AID1259255; AID1259256 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 (µMol) | 212.0000 | 212.0000 | 1,235.3333 | 2,000.0000 | AID977608 |
| Chain A, Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 (µMol) | 212.0000 | 212.0000 | 1,235.3333 | 2,000.0000 | AID977608 |
| Chain A, Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 (µMol) | 212.0000 | 212.0000 | 1,235.3333 | 2,000.0000 | AID977608 |
| Chain A, Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 (µMol) | 212.0000 | 212.0000 | 1,235.3333 | 2,000.0000 | AID977608 |
| Chain A, Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 (µMol) | 212.0000 | 212.0000 | 1,235.3333 | 2,000.0000 | AID977608 |
| Chain A, Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 (µMol) | 212.0000 | 212.0000 | 1,235.3333 | 2,000.0000 | AID977608 |
| Chain A, Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 (µMol) | 212.0000 | 212.0000 | 1,235.3333 | 2,000.0000 | AID977608 |
| Chain A, Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 (µMol) | 212.0000 | 212.0000 | 1,235.3333 | 2,000.0000 | AID977608 |
| Chain A, Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 (µMol) | 212.0000 | 212.0000 | 1,235.3333 | 2,000.0000 | AID977608 |
| Chain A, Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 (µMol) | 212.0000 | 212.0000 | 1,235.3333 | 2,000.0000 | AID977608 |
| Chain A, Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 (µMol) | 212.0000 | 212.0000 | 1,235.3333 | 2,000.0000 | AID977608 |
| Chain A, Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 (µMol) | 212.0000 | 212.0000 | 1,235.3333 | 2,000.0000 | AID977608 |
| Chain A, Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 (µMol) | 212.0000 | 212.0000 | 1,235.3333 | 2,000.0000 | AID977608 |
| Chain A, Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 (µMol) | 212.0000 | 212.0000 | 1,235.3333 | 2,000.0000 | AID977608 |
| Chain A, Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 (µMol) | 212.0000 | 212.0000 | 1,235.3333 | 2,000.0000 | AID977608 |
| Chain A, Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 (µMol) | 212.0000 | 212.0000 | 1,235.3333 | 2,000.0000 | AID977608 |
| Chain A, Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 (µMol) | 212.0000 | 212.0000 | 1,235.3333 | 2,000.0000 | AID977608 |
| M18 aspartyl aminopeptidase | Plasmodium falciparum 3D7 | IC50 (µMol) | 2.2420 | 0.3851 | 13.0782 | 100.0000 | AID2195 |
| Vif | Human immunodeficiency virus 1 | IC50 (µMol) | 25.3100 | 0.2700 | 34.0015 | 100.0000 | AID1117319 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | IC50 (µMol) | 25.3100 | 0.2700 | 26.3638 | 100.0000 | AID1117319 |
| Aryl hydrocarbon receptor | Oryctolagus cuniculus (rabbit) | Ki | 0.3743 | 0.0077 | 0.2332 | 0.7850 | AID1798379; AID239550 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 (µMol) | 1,000.0000 | 0.0000 | 0.9453 | 9.9400 | AID1470910 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 (µMol) | 45.9500 | 0.0340 | 3.9871 | 10.0000 | AID305160; AID493982; AID719277 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 0.9500 | 0.0002 | 1.1043 | 9.9000 | AID501912 |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | IC50 (µMol) | 12.6000 | 0.0031 | 2.1602 | 9.6000 | AID1435567; AID1854423 |
| Transient receptor potential cation channel subfamily A member 1 | Homo sapiens (human) | IC50 (µMol) | 15.3750 | 0.0510 | 2.4725 | 7.5000 | AID1467685; AID1467699 |
| Tyrosine-protein kinase ABL1 | Homo sapiens (human) | IC50 (µMol) | 28.0000 | 0.0001 | 0.7128 | 10.0000 | AID264592 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 2.2100 | 0.0000 | 1.3726 | 10.0000 | AID501903 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 2.7700 | 0.0000 | 0.7236 | 9.9200 | AID501904 |
| Myc proto-oncogene protein | Homo sapiens (human) | IC50 (µMol) | 60.0000 | 1.0000 | 5.7325 | 9.6700 | AID738187 |
| Estrogen receptor | Homo sapiens (human) | Ki | 0.5797 | 0.0000 | 0.4229 | 7.9070 | AID1798379; AID239674 |
| Cytochrome P450 1A1 | Homo sapiens (human) | IC50 (µMol) | 22.6667 | 0.0079 | 1.2478 | 9.9000 | AID1306441; AID1533723; AID1533724 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 (µMol) | 11.5375 | 0.0005 | 3.8895 | 10.0000 | AID1305341; AID1305342; AID1392707; AID1418623; AID1428599; AID1436091; AID1436093; AID1571122; AID1700052; AID1872722; AID759460; AID761463 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 (µMol) | 3.0000 | 0.0001 | 1.7740 | 10.0000 | AID625245 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 (µMol) | 2.0250 | 0.0003 | 2.1774 | 10.0000 | AID1278605; AID271286; AID289278; AID491617 |
| Tyrosine-protein kinase Lck | Homo sapiens (human) | IC50 (µMol) | 112.0000 | 0.0002 | 1.3173 | 10.0000 | AID164858 |
| Cholinesterase | Homo sapiens (human) | IC50 (µMol) | 5.0000 | 0.0000 | 1.5599 | 10.0000 | AID1480847 |
| Cathepsin D | Homo sapiens (human) | IC50 (µMol) | 138.0000 | 0.0000 | 0.9316 | 10.0000 | AID1391984 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 9.0900 | 0.0002 | 2.0102 | 10.0000 | AID501905 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 13.6560 | 0.0004 | 1.8773 | 10.0000 | AID625207; AID641150 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 2.2930 | 0.0032 | 2.2887 | 9.3160 | AID625207 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 (µMol) | 60.0000 | 0.0002 | 2.3185 | 10.0000 | AID264590 |
| Luciferin 4-monooxygenase | Photinus pyralis (common eastern firefly) | IC50 (µMol) | 0.0589 | 0.0589 | 3.1426 | 10.0000 | AID725947 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 (µMol) | 8.1500 | 0.0001 | 1.7536 | 10.0000 | AID1534711; AID625251 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 20.0000 | 0.0001 | 1.4162 | 9.9000 | AID589144 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 0.6850 | 0.0003 | 0.3095 | 2.3000 | AID271286; AID370920 |
| DNA polymerase alpha catalytic subunit | Homo sapiens (human) | IC50 (µMol) | 3.3000 | 1.0000 | 2.7429 | 4.3000 | AID1662436 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 (µMol) | 4.9000 | 0.0001 | 1.6847 | 9.3200 | AID1570237 |
| Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 (µMol) | 289.0000 | 0.0005 | 1.2854 | 7.6500 | AID420374; AID420375 |
| Breakpoint cluster region protein | Homo sapiens (human) | IC50 (µMol) | 28.0000 | 0.0003 | 0.6200 | 10.0000 | AID264592 |
| Tyrosinase | Mus musculus (house mouse) | IC50 (µMol) | 10.7800 | 0.0300 | 2.2104 | 5.2300 | AID1801525 |
| Aromatase | Homo sapiens (human) | IC50 (µMol) | 30.2267 | 0.0000 | 1.2904 | 10.0000 | AID1390538; AID1770524; AID1798975; AID642091; AID650842; AID719271 |
| Aromatase | Homo sapiens (human) | Ki | 41.6700 | 0.0000 | 0.6046 | 9.5010 | AID650843 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 (µMol) | 7.0000 | 0.0000 | 2.8005 | 10.0000 | AID625248 |
| Ornithine decarboxylase | Homo sapiens (human) | IC50 (µMol) | 19.0000 | 3.4000 | 4.0500 | 4.7000 | AID378353 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 0.6850 | 0.0003 | 0.3209 | 2.3000 | AID271286; AID370920 |
| Tyrosinase | Homo sapiens (human) | IC50 (µMol) | 985.1750 | 0.0230 | 4.4593 | 10.0000 | AID1611934; AID1717733; AID1717735; AID598386 |
| Ribosyldihydronicotinamide dehydrogenase [quinone] | Homo sapiens (human) | IC50 (µMol) | 1.3972 | 0.0027 | 1.6287 | 9.9000 | AID1281396; AID1281398; AID1391153; AID1566052; AID1798975; AID1799023; AID1826998; AID418720; AID459814; AID479979; AID587229; AID770333 |
| Ribosyldihydronicotinamide dehydrogenase [quinone] | Homo sapiens (human) | Ki | 0.0880 | 0.0065 | 0.0436 | 0.0880 | AID770334 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 (µMol) | 525.0000 | 0.0005 | 3.4984 | 9.7600 | AID1647483; AID409730 |
| Nuclear factor NF-kappa-B p105 subunit | Homo sapiens (human) | IC50 (µMol) | 2.5000 | 0.0001 | 1.9731 | 8.0000 | AID1182047 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 (µMol) | 9.8297 | 0.0000 | 2.3789 | 9.7700 | AID1534711; AID1826663; AID1872746; AID625150 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 (µMol) | 5.0000 | 0.0000 | 0.9332 | 10.0000 | AID1480845 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 4.4700 | 0.0002 | 1.9720 | 9.9200 | AID501906 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 (µMol) | 49.5138 | 0.0002 | 1.5574 | 10.0000 | AID258724; AID332217; AID370919; AID625243 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 8.0700 | 0.0001 | 1.4710 | 9.9200 | AID501909 |
| Sucrase-isomaltase, intestinal | Rattus norvegicus (Norway rat) | IC50 (µMol) | 400.0000 | 0.0400 | 1.8483 | 10.0000 | AID641148 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 (µMol) | 2.3120 | 0.0008 | 1.5416 | 20.0000 | AID625207 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 2.2930 | 0.0003 | 1.4656 | 10.0000 | AID625207 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 (µMol) | 22.2367 | 0.0000 | 1.8914 | 9.5700 | AID1534712; AID1826665; AID1872721 |
| Dipeptidyl peptidase 4 | Homo sapiens (human) | IC50 (µMol) | 0.0006 | 0.0001 | 0.4444 | 10.0000 | AID1395903 |
| ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 6.0000 | 6.8333 | 8.2000 | AID603318 |
| Nitric oxide synthase, inducible | Mus musculus (house mouse) | IC50 (µMol) | 20.4667 | 0.0010 | 3.3911 | 9.6000 | AID491613; AID650853; AID719267 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 (µMol) | 3.0000 | 0.0000 | 2.3983 | 10.0000 | AID625247 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 4.7500 | 0.0000 | 1.2725 | 9.9000 | AID501907 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 (µMol) | 6.0046 | 0.0001 | 0.9950 | 10.0000 | AID1278606; AID1424466; AID289279; AID332218; AID370920; AID403340; AID491615 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 4.3500 | 0.0002 | 1.3737 | 9.9000 | AID501910 |
| Cannabinoid receptor 1 | Mus musculus (house mouse) | IC50 (µMol) | 1,000.0000 | 0.0030 | 0.9294 | 3.2000 | AID409730 |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | IC50 (µMol) | 3.4900 | 0.0010 | 1.4539 | 10.0000 | AID271287 |
| Cholinesterase | Equus caballus (horse) | IC50 (µMol) | 400.0000 | 0.0000 | 2.2214 | 9.4000 | AID1470911 |
| Nuclear factor NF-kappa-B p100 subunit | Homo sapiens (human) | IC50 (µMol) | 2.5000 | 0.0001 | 1.8088 | 8.0000 | AID1182047 |
| Squalene synthase | Rattus norvegicus (Norway rat) | IC50 (µMol) | 50.0000 | 0.0002 | 0.4543 | 4.2000 | AID1499671 |
| Transcription factor p65 | Homo sapiens (human) | IC50 (µMol) | 2.5000 | 0.0001 | 1.8981 | 8.8000 | AID1182047 |
| Bcl-2-like protein 1 | Homo sapiens (human) | IC50 (µMol) | 190.0000 | 0.0003 | 1.0482 | 9.5400 | AID481128 |
| Serine/threonine-protein kinase PAK 1 | Homo sapiens (human) | IC50 (µMol) | 15.0000 | 0.0002 | 0.3001 | 2.5000 | AID1424461 |
| Cytochrome P450 1B1 | Homo sapiens (human) | IC50 (µMol) | 28.2000 | 0.0013 | 0.8696 | 9.9000 | AID1306443; AID1533710 |
| Cytochrome P450 1B1 | Homo sapiens (human) | Ki | 3.2317 | 0.0030 | 0.9741 | 7.4600 | AID1452978; AID1452983; AID1533726; AID1799522 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 0.8100 | 0.0001 | 0.7874 | 9.9000 | AID502077 |
| Tubulin beta-2B chain | Bos taurus (cattle) | IC50 (µMol) | 40.0000 | 0.2500 | 1.8838 | 8.7000 | AID228461 |
| Lysosomal alpha-glucosidase | Rattus norvegicus (Norway rat) | IC50 (µMol) | 400.0000 | 0.0800 | 2.5061 | 9.8500 | AID641146 |
| Transient receptor potential cation channel subfamily A member 1 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 6.1975 | 0.4500 | 3.4243 | 7.5000 | AID1272520; AID1272522; AID1272530; AID1272531 |
| Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | IC50 (µMol) | 40.0000 | 0.2500 | 1.8779 | 8.7000 | AID228461 |
| Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | IC50 (µMol) | 40.0000 | 0.2500 | 1.8656 | 8.7000 | AID228461 |
| Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 4.0900 | 0.0003 | 1.2309 | 9.8000 | AID501913 |
| Carbonic anhydrase 15 | Mus musculus (house mouse) | Ki | 9.3600 | 0.0009 | 1.8846 | 10.0000 | AID501915 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 0.8300 | 0.0002 | 1.5099 | 9.9000 | AID501914 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 4.6400 | 0.0000 | 1.3412 | 9.9700 | AID501908 |
| large T antigen | Betapolyomavirus macacae | IC50 (µMol) | 26.2000 | 0.1600 | 24.9724 | 100.0000 | AID1903 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 8.1300 | 0.0002 | 1.1043 | 9.9000 | AID657374 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 2.1800 | 0.0000 | 1.3726 | 10.0000 | AID657368 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 1.7500 | 0.0000 | 0.7236 | 9.9200 | AID657370 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 6.7500 | 0.0002 | 2.0102 | 10.0000 | AID657376 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 4.0100 | 0.0002 | 1.9720 | 9.9200 | AID657377 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 8.6300 | 0.0001 | 1.4710 | 9.9200 | AID657379 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 2.8600 | 0.0000 | 1.2725 | 9.9000 | AID657384 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 8.9800 | 0.0002 | 1.3737 | 9.9000 | AID657380 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 9.5300 | 0.0001 | 0.7874 | 9.9000 | AID657372 |
| Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 8.2500 | 0.0003 | 1.2309 | 9.8000 | AID657381 |
| Carbonic anhydrase 15 | Mus musculus (house mouse) | Ki | 2.5700 | 0.0009 | 1.8846 | 10.0000 | AID657383 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 1.9500 | 0.0002 | 1.5099 | 9.9000 | AID657382 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 3.2400 | 0.0000 | 1.3412 | 9.9700 | AID657378 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, Troponin C, slow skeletal and cardiac muscles | Homo sapiens (human) | Kd | 243.0000 | 243.0000 | 243.0000 | 243.0000 | AID977611 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | EC50 (µMol) | 5.2030 | 0.0590 | 5.5596 | 27.2100 | AID1241 |
| transcription factor p65 isoform 1 | Homo sapiens (human) | EC50 (µMol) | 5.2030 | 0.0590 | 5.5596 | 27.2100 | AID1241 |
| serine/threonine-protein kinase 33 isoform a | Homo sapiens (human) | EC50 (µMol) | 12.3300 | 0.7691 | 14.6096 | 44.8900 | AID2821 |
| POsterior Segregation | Caenorhabditis elegans | EC50 (µMol) | 300.0000 | 2.2010 | 47.1808 | 186.6810 | AID1964 |
| Estrogen receptor beta | Mus musculus (house mouse) | EC50 (µMol) | 5.2030 | 0.0590 | 5.5596 | 27.2100 | AID1241 |
| Transient receptor potential cation channel subfamily A member 1 | Homo sapiens (human) | EC50 (µMol) | 30.0000 | 0.0003 | 3.1662 | 10.0000 | AID1467684 |
| Transthyretin | Homo sapiens (human) | Kd | 0.4700 | 0.0030 | 1.3482 | 10.0000 | AID1452013 |
| Amyloid-beta precursor protein | Homo sapiens (human) | Kd | 38.5000 | 1.9000 | 1.9000 | 1.9000 | AID1399537 |
| Ribosyldihydronicotinamide dehydrogenase [quinone] | Homo sapiens (human) | Kd | 0.0540 | 0.0040 | 6.7556 | 88.9030 | AID770330 |
| Protein kinase C alpha type | Homo sapiens (human) | EC50 (µMol) | 5,780.0000 | 0.0095 | 0.3307 | 0.9100 | AID614623 |
| Estrogen receptor | Mus musculus (house mouse) | EC50 (µMol) | 5.2030 | 0.0590 | 5.5596 | 27.2100 | AID1241 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | EC50 (µMol) | 163.1310 | 0.0820 | 31.0243 | 168.9080 | AID1960 |
| Nuclear factor erythroid 2-related factor 2 | Homo sapiens (human) | EC50 (µMol) | 5.4000 | 0.0600 | 2.6167 | 9.9000 | AID1339465 |
| NAD-dependent protein deacetylase sirtuin-2 | Homo sapiens (human) | EC50 (µMol) | 300.0000 | 0.1600 | 0.1600 | 0.1600 | AID331041 |
| NAD-dependent protein deacetylase sirtuin-1 | Homo sapiens (human) | EC50 (µMol) | 52.3333 | 0.1600 | 1.0543 | 2.9000 | AID331040; AID735922; AID735925 |
| NAD-dependent protein deacetylase sirtuin-3, mitochondrial | Homo sapiens (human) | EC50 (µMol) | 177.5950 | 0.1700 | 1.7100 | 3.2500 | AID1780359; AID331042 |
| Zinc finger protein mex-5 | Caenorhabditis elegans | EC50 (µMol) | 163.1310 | 0.0820 | 33.5679 | 168.9080 | AID1960 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| FAD-linked sulfhydryl oxidase ALR | Homo sapiens (human) | AC50 | 4.0210 | 0.0050 | 3.2126 | 22.7870 | AID493248 |
| Nuclear factor erythroid 2-related factor 2 | Homo sapiens (human) | CD | 21.0000 | 0.5400 | 1.1533 | 1.6800 | AID1826670 |
| NAD(P)H dehydrogenase [quinone] 1 | Mus musculus (house mouse) | CD | 29.2857 | 0.0002 | 0.2389 | 2.6500 | AID1182051; AID491526; AID642329; AID650846; AID719273; AID719274; AID719275 |
| NAD-dependent protein deacetylase sirtuin-1 | Homo sapiens (human) | Activity | 48.0000 | 0.1600 | 0.9800 | 1.8000 | AID347335 |
| NAD-dependent protein deacetylase sirtuin-1 | Homo sapiens (human) | EC1.5 (µMol) | 46.1333 | 0.1600 | 0.1600 | 0.1600 | AID1440193; AID1896329; AID349547 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588461 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, Validation compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588461 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, Validation compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588461 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, Validation compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588459 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, Validation compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588459 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, Validation compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588459 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, Validation compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID588460 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, Validation Compound Set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588460 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, Validation Compound Set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588460 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, Validation Compound Set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1346800 | Human Peroxisome proliferator-activated receptor-gamma (1C. Peroxisome proliferator-activated receptors) | 2014 | Chembiochem : a European journal of chemical biology, May-26, Volume: 15, Issue:8 | Resveratrol and its metabolites bind to PPARs. |
| AID1345206 | Human COX-2 (Cyclooxygenase) | 2010 | Journal of medicinal chemistry, Jul-08, Volume: 53, Issue:13 | Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. |
| AID396591 | Antileishmanial activity against Leishmania braziliensis MHOM/BR/75/M2903 promastigotes assessed as lysis of promastigotes at 100 ug/ml after 72 hrs | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Activity of a hydroxybibenzyl bryophyte constituent against Leishmania spp. and Trypanosoma cruzi: in silico, in vitro and in vivo activity studies. |
| AID359119 | Reversal of induction of BMP2 expression in mouse MC3T3-E1 cells at 1 uM by Western blot in presence of ICI-182780 | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1884053 | Antibacterial activity against Bacillus cereus ATCC 14579 incubated for 20 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID1676774 | Induction of membrane perturbation in DC22:1PC LUV bilayer assessed as effect on potential of mean force by measuring reduction in deltaG for gramicidin mixture monomer to dimer and pure gramicidin-bilayer by fluorescence quenching assay | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20 | Assessing the Perturbing Effects of Drugs on Lipid Bilayers Using Gramicidin Channel-Based |
| AID340412 | Inhibition of NO release in LPS-stimulated rat cortical microglial cells assessed as nitrite accumulation at 30 uM after 48 hrs relative to LPS | 2008 | Journal of natural products, Jul, Volume: 71, Issue:7 | Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia. |
| AID331068 | Reduction of blood glucose level in DIO C57BL/6 mouse model at 500 mg/kg, po after 4 weeks | 2007 | Nature, Nov-29, Volume: 450, Issue:7170 | Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. |
| AID331077 | Activation of human SIRT1 assessed as decrease in Km of enzyme for acetylated peptide substrate by mass spectrometry assay | 2007 | Nature, Nov-29, Volume: 450, Issue:7170 | Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. |
| AID549851 | Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced oxytosis after 24 hrs by MTT assay relative to resveratrol | 2011 | Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1 | New hydroxystilbenoid derivatives endowed with neuroprotective activity and devoid of interference with estrogen and aryl hydrocarbon receptor-mediated transcription. |
| AID724377 | Antioxidant activity in planer lipid bilayer membrane assessed as reduction in 100 uM DPPH-induced charge transfer resistance at 50 uM by admittance spectroscopic analysis | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Dose-dependent interaction of trans-resveratrol with biomembranes: effects on antioxidant property. |
| AID735490 | Activation of SIRT1 in human MCF7 cells assessed as reduction in doxorubicin-induced acetyl-p53 level at >100 uM after 6 hrs by Western blotting analysis | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate. |
| AID1278613 | Antiinflammatory activity in carrageenan-induced BALB/c mouse paw edema model assessed as decrease in paw volume at 20 mg/kg, po administered 30 mins prior to carrageenan challenge measured after 6 hrs by plethysmometric analysis relative to control | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog. |
| AID1347866 | Inhibition of alpha-MSH-induced reactive oxygen species generation in human A375 cells at 25 uM after 4 hrs by DCFDA staining-based fluorescence assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, synthesis and evaluation of novel dihydrostilbene derivatives as potential anti-melanogenic skin-protecting agents. |
| AID359545 | Effect on vascular endothelial growth factor B gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1298302 | Reduction in dCTP level in human U373-MAGI cells at 200 uM after 6 hrs by LC-MS/MS analysis | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1378332 | Inhibition of self-induced Amyloid beta (1 to 42) (unknown origin) aggregation at 25 uM after 48 hrs by thioflavin T-based fluorometric assay relative to control | 2017 | European journal of medicinal chemistry, Sep-29, Volume: 138 | Design, synthesis and evaluation of coumarin-pargyline hybrids as novel dual inhibitors of monoamine oxidases and amyloid-β aggregation for the treatment of Alzheimer's disease. |
| AID1238825 | Retention time of the compound in C57BL/6J mouse intestine content treated with RAH at 200 mg/kg, ig by HPLC-CEAD analysis | 2015 | Journal of medicinal chemistry, Aug-27, Volume: 58, Issue:16 | Novel Resveratrol-Based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer Activity. |
| AID746976 | Half life in human | 2013 | Bioorganic & medicinal chemistry letters, May-15, Volume: 23, Issue:10 | A new synthesis of 4'-resveratrol esters and evaluation of the potential for anti-depressant activity. |
| AID738195 | Inhibition of smad3/4 signaling pathway in human HeLa cells assessed as measured as lowest concentration required 50 to 60 % inhibition of TGF-beta induced luciferase treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID1371368 | Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID667227 | Cytotoxicity against human 850C cells after 96 hrs by SRB assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents. |
| AID719275 | Induction of quinone reductase-1 activity in mouse Hepa-1c1c7 cells after 48 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1). |
| AID1168364 | Hepatoprotective activity against isoniazid-rifampicin induced liver injury in BALB/c mouse assessed as reduction in IFN-gamma level at 100 mg/kg, po bid for 3 days starting 30 mins prior isoniazid-rifampicin administration measured 24 hrs post-last dose | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. |
| AID479118 | Cell cycle arrest in human H460 cells assessed as accumulation at G2/M phase at 20 uM after 24 hrs by propidium iodide staining-based flow cytometry | 2010 | Bioorganic & medicinal chemistry, May-15, Volume: 18, Issue:10 | Design, synthesis and anticancer activities of stilbene-coumarin hybrid compounds: Identification of novel proapoptotic agents. |
| AID1399533 | Permeability of the compound at 100 ug/ml after 10 hrs by artificial membrane permeability assay | 2018 | Bioorganic & medicinal chemistry, 09-01, Volume: 26, Issue:16 | Synthesis and evaluation of 1,2,3,4-tetrahydro-1-acridone analogues as potential dual inhibitors for amyloid-beta and tau aggregation. |
| AID1311766 | Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as PGE2 levels at 5 umol/L by ELISA (Rvb = 33.2 +/- 2.33 pg/mL) | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata. |
| AID1245575 | Antiproliferative activity against human MDA-MB-231 cells assessed as cell survival at 100 uM after 48 hrs by MTT assay relative to control | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Deprotometalation-iodolysis and computed CH acidity of 1,2,3- and 1,2,4-triazoles. Application to the synthesis of resveratrol analogues. |
| AID440568 | Inhibition of human MSC senescence assessed as appearance of senescence-associated beta-galactosidase positive cells at 50 uM after 48 hrs by optic microscopy relative to control | 2009 | Journal of medicinal chemistry, Sep-10, Volume: 52, Issue:17 | Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors. |
| AID650843 | Competitive inhibition of human aromatase using dibenzylfluorescein substrate after 10 mins preincubation measured every 10 sec for 5 mins by Michaelis-Menten and Dixon plot analysis | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7 | Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol. |
| AID359296 | Effect on alkaline phosphatase 2 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1461520 | Antioxidant activity assessed as ABTS free radical scavenging activity by measuring trolox equivalents after 6 mins | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Synthesis and evaluation of hydroxychalcones as multifunctional non-purine xanthine oxidase inhibitors for the treatment of hyperuricemia. |
| AID1430684 | Tmax in Wistar rat at 20 mg/kg, po by HPLC-MS analysis | 2017 | ACS medicinal chemistry letters, May-11, Volume: 8, Issue:5 | Toward Resolving the Resveratrol Conundrum: Synthesis and |
| AID726359 | Antioxidant activity against CCl4-induced oxidative hepatic injury Wistar albino rat model assessed as effect on liver cytosolic catalase activity per mg protein at 100 mg/kg, ip for 7 consecutive days prior to CCL4 challenge measured 24 hrs post CCl4 cha | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Antioxidant activities of thiosemicarbazones from substituted benzaldehydes and N-(tetra-O-acetyl-β-D-galactopyranosyl)thiosemicarbazide. |
| AID359052 | Reversal of increase in ER.DNA complex in mouse MC3T3-E1 cells transfected with dominant-negative mutant Src expression vector at 1 uM by RT-PCR | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID637958 | Antibacterial activity against CagA-deficient Helicobacter pylori G12 isolated from chronic gastritis patient after 48 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1264956 | Cytotoxicity against human MSC assessed as cell viability at 1 uM treated for 6 days measured on day 7 by alamar blue assay (Rvb = 96 to 101%) | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11 | Defining Key Structural Determinants for the Pro-osteogenic Activity of Flavonoids. |
| AID768928 | Inhibition of human thrombin amidolytic activity using D-Phe-Pip-Arg-pNA as substrate at 0.1 to 1000 uM preincubated for 10 mins followed by substrate addition measured every 12 secs for 10 mins by spectrophotometric analysis | 2014 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 23 | Thrombin inhibitory activity of some polyphenolic compounds. |
| AID549841 | Antagonist activity at estrogen receptor in human Ishikawa cells assessed as inhibition of estradiol-induced alkaline phosphatase expression at 1 uM after 72 hrs relative to ICI182780 | 2011 | Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1 | New hydroxystilbenoid derivatives endowed with neuroprotective activity and devoid of interference with estrogen and aryl hydrocarbon receptor-mediated transcription. |
| AID359298 | Effect on bone gamma carboxyglutamate protein 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID259476 | Cytotoxicity against human pancreatic carcinoma FG2 cell line by MTT assay at 100 uM | 2006 | Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2 | Rapid synthesis of triazole-modified resveratrol analogues via click chemistry. |
| AID1354540 | Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced nitric oxide production after 24 hrs by Griess assay | 2018 | Journal of natural products, 05-25, Volume: 81, Issue:5 | Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner. |
| AID655171 | Cytotoxicity against human QSG7701 cells after 24 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5 | A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. |
| AID1480848 | Inhibition of human serum BuChE at 5 uM using butylthiocholine chloride as substrate pretreated for 15 mins followed by substrate addition measured for 2 mins by DTNB reagent based spectrophotometric method relative to control | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment. |
| AID1534712 | Inhibition of human MAO-B preincubated for 15 mins followed by p-tyramine substrate addition and measured after 20 mins by Amplex red reagent based fluorescence assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease. |
| AID331052 | Activation of human SIRT1-F (230-664) construct by mass spectrometry assay relative to control | 2007 | Nature, Nov-29, Volume: 450, Issue:7170 | Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. |
| AID1632198 | Cytotoxicity against human DU145 cells after 48 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18 | Synthesis and anticancer activity of a hydroxytolan series. |
| AID617266 | Radioprotective activity against 0 to 7 Gy gamma radiation-induced death in mouse 32Dcl3 cells at 10 uM treated 1 hr prior to irradiation after 7 days by microscopy | 2011 | ACS medicinal chemistry letters, Jan-25, Volume: 2, Issue:4 | The Use of 3,5,4'-Tri-O-acetylresveratrol as a Potential Pro-drug for Resveratrol Protects Mice from γ-Irradiation-Induced Death. |
| AID1362649 | Inhibition of self-induced amyloid beta (1 to 40) (unknown origin) fibril aggregation assessed as aggregation level at 100 uM measured on day 10 by UV-visible turbidity method (Rvb = 100 +/- 7.83%) | |||
| AID1298352 | Antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as increase in frequency of G to C transversion at 50 uM incubated for 4 hrs prior to infection measured at 72 hrs post infection by illumina sequencing me | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1354538 | Inhibition of PI3K/Akt in mouse J774 cells assessed as reduction in LPS-induced Akt phosphorylation at Ser473 after 4 hrs by Western blot analysis | 2018 | Journal of natural products, 05-25, Volume: 81, Issue:5 | Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner. |
| AID1609867 | Inhibition of insulin-induced SGK1 in human HUH7 cells at 100 uM using peptide as substrate incubated for 6 hrs by scintillation counter method | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Review about the multi-target profile of resveratrol and its implication in the SGK1 inhibition. |
| AID1611502 | Antioxidant activity assessed as DPPH free radical scavenging activity at 200 uM incubated for 60 mins by spectrophotometric method relative to control | 2019 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 29, Issue:24 | Synthesis and evaluation of 1,3,5-triazine derivatives as sunscreens useful to prevent skin cancer. |
| AID501913 | Inhibition of human carbonic anhydrase 13 after 15 mins by stopped flow CO2 hydration method | 2010 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17 | Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. |
| AID1385449 | Antiproliferative activity against human MCF7 cells after 72 hrs in presence of OBHS by MTT assay | 2018 | Journal of medicinal chemistry, 09-27, Volume: 61, Issue:18 | Novel Hybrid Conjugates with Dual Suppression of Estrogenic and Inflammatory Activities Display Significantly Improved Potency against Breast Cancer. |
| AID1884085 | Bactericidal activity against Staphylococcus aureus LMG 8224 at 128 uM measured upto 24 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID1371370 | Cytotoxicity against human HT-29 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID359513 | Effect on integrin beta 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1632197 | Cytotoxicity against human MHRF cells after 24 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18 | Synthesis and anticancer activity of a hydroxytolan series. |
| AID491617 | Inhibition of sheep seminal vesicles COX1 assessed as PGE2 production after 10 mins by ELISA | 2010 | Journal of medicinal chemistry, Jul-08, Volume: 53, Issue:13 | Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. |
| AID1632220 | Selectivity index, ratio of CD50 against human MHRF cells to CD50 for human MDAH 2774 cells after 24 hrs | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18 | Synthesis and anticancer activity of a hydroxytolan series. |
| AID359338 | Effect on fibroblast growth factor 2 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1718918 | Cytotoxicity against human MNNG/HOS cells incubated for 48 hrs by CCK-8 assay | 2020 | Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24 | Cancer Stem Cell (CSC) Inhibitors in Oncology-A Promise for a Better Therapeutic Outcome: State of the Art and Future Perspectives. |
| AID1884071 | Cytotoxicity against human MRC5 cells assessed as cellular metabolism incubated for 72 hrs by MTT assay | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID1718917 | Selectivity ratio of IC50 for human MNNG/HOS cells to IC50 for human MG-63 cells | 2020 | Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24 | Cancer Stem Cell (CSC) Inhibitors in Oncology-A Promise for a Better Therapeutic Outcome: State of the Art and Future Perspectives. |
| AID1878993 | Inhibition of TGF-beta1 induced apoptosis in C57/B6J mouse primary hepatocytes assessed as dead cells at 50 uM by Annexin-V-FITC-H and PI staining based flow cytometry analysis (Rvb = 3.09 %) | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID1357647 | Lipid lowering activity in zebrafish embryos at 5 uM by Nile red fat metabolism assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Lipid reducing activity and toxicity profiles of a library of polyphenol derivatives. |
| AID1203642 | Cell cycle arrest in human Bel7402 cells assessed as cells accumulation at G1 phase at 50 uM after 48 hrs by flow cytometry (Rvb = 62.60%) | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Design, synthesis, and biological evaluation of benzoselenazole-stilbene hybrids as multi-target-directed anti-cancer agents. |
| AID1611499 | Photoprotection activity against UV radiation assessed as ratio of UVA to UVB | 2019 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 29, Issue:24 | Synthesis and evaluation of 1,3,5-triazine derivatives as sunscreens useful to prevent skin cancer. |
| AID416361 | Inhibition of Fe(2+)/ascorbate-induced lipid peroxidation in human erythrocyte ghosts assessed as inhibition of malondialdehyde formation per mg of protein at 2 uM after 30 mins | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6 | 4,4'-Dihydroxy-trans-stilbene, a resveratrol analogue, exhibited enhanced antioxidant activity and cytotoxicity. |
| AID716923 | Cytotoxicity against mouse B16F10 cells assessed as suppression of cell viability after 72 hrs | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID692948 | Inhibition of Wnt/beta-casein in human LS174T cells assessed as reduction in Lgr5 mRNA level at 100 uM after 36 hrs by RT-PCR analysis | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID1609874 | Antiproliferative activity against human HuH7 cells overexpressing SGK1 assessed as reduction in cell viability at 100 uM incubated for 48 hrs by trypan blue dye based assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Review about the multi-target profile of resveratrol and its implication in the SGK1 inhibition. |
| AID610232 | Antiinflammatory activity in C57BL/6J mouse model of DSS-induced colon inflammation assessed as reduction in disease activity index at 2.1 mg/kg/day, po for 8 days co-administered with DSS measure on day 8 | 2010 | Journal of medicinal chemistry, Oct-28, Volume: 53, Issue:20 | Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents. |
| AID359180 | Inhibition of 2-[1,2-3H(N)]deoxy-D-glucose uptake in human U937 cells at >100 uM by scintillation spectrometry in presence of sodium-free buffer | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3 | Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells. |
| AID1371373 | Cytotoxicity against human NCI-H460 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID638159 | Bactericidal activity against CagA-expressing Helicobacter pylori G39 isolated from chronic gastritis patient compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID458150 | Antimicrobial activity against Streptococcus mutans KCTC 3065 after 20 hrs by plate dilution method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | The antimicrobial activity of compounds from the leaf and stem of Vitis amurensis against two oral pathogens. |
| AID458146 | Antimicrobial activity against Streptococcus sanguinis NCTC 9811 at 100 ug/ml after 20 hrs by disk diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | The antimicrobial activity of compounds from the leaf and stem of Vitis amurensis against two oral pathogens. |
| AID1309162 | Binding affinity to Fe2+ using FeCl2 at 20 uM after 5 mins by spectrophotometry | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Ionophoric polyphenols selectively bind Cu(2+), display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila. |
| AID730560 | Antinociceptive activity in Swiss mouse assessed as inhibition of capsaicin-induced biting behavior at 300 ug/site, administered intrathecally | 2013 | Journal of natural products, Jan-25, Volume: 76, Issue:1 | Evidence for the analgesic activity of resveratrol in acute models of nociception in mice. |
| AID730566 | Antinociceptive activity in Swiss mouse assessed as inhibition of capsaicin-induced spontaneous nociception at 300 ug/site, administered as intrathecally | 2013 | Journal of natural products, Jan-25, Volume: 76, Issue:1 | Evidence for the analgesic activity of resveratrol in acute models of nociception in mice. |
| AID1298413 | Antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as reduction in U5-gag level at 50 uM measured at 12 to 72 hrs post infection by qPCR method | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID638156 | Bactericidal activity against CagA-expressing Helicobacter pylori G27 isolated from chronic gastritis patient compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID730563 | Antinociceptive activity in Swiss mouse assessed as inhibition of capsaicin-induced spontaneous nociception at 300 ug/site, icv | 2013 | Journal of natural products, Jan-25, Volume: 76, Issue:1 | Evidence for the analgesic activity of resveratrol in acute models of nociception in mice. |
| AID738175 | Inhibition of Hedgehog signaling pathway in human HeLa cells assessed as inhibition of PMA induced luciferase treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID377036 | Ex vivo inhibition of leukotriene formation in calcium ionophore activated human neutrophilic granulocyte by ELISA | 2005 | Journal of natural products, Jan, Volume: 68, Issue:1 | Inhibition of leukotriene biosynthesis by stilbenoids from Stemona species. |
| AID1281402 | Cytotoxicity against human T47D cells after 96 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Non-symmetrical furan-amidines as novel leads for the treatment of cancer and malaria. |
| AID1371380 | Cytotoxicity against human MDA-MB-231 cells assessed as cell viability at 16 uM after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1362639 | Inhibition of Cu2+ induced amyloid beta (1 to 40) fibril aggregation assessed as aggregation level at 100 uM measured on day 3 by UV-visible turbidity method (Rvb = 100 +/- 17.24%) | |||
| AID359072 | Increase in proliferation of rat primary osteoblast cells at 0.1 to 10 uM after 24 hr by flow cytometry | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1054190 | Antiviral activity against HIV1 infected in human U373-MAGI cells assessed as A to G mutation at 50 uM (Rvb = 22%) | 2013 | Bioorganic & medicinal chemistry, Nov-15, Volume: 21, Issue:22 | 5,6-Dihydro-5-aza-2'-deoxycytidine potentiates the anti-HIV-1 activity of ribonucleotide reductase inhibitors. |
| AID359500 | Effect on fibroblast growth factor receptor 2 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID762885 | Induction of mitochondrial biogenesis in H2O2-induced HUVEC at 100 umol/L pretreated for 1 day followed by compound washout and H2O2-treatment measured after 10 days by MitoTracker Red staining-based assay | 2013 | Journal of natural products, Jul-26, Volume: 76, Issue:7 | trans-Resveratrol in Gnetum gnemon protects against oxidative-stress-induced endothelial senescence. |
| AID1418634 | Disaggregation of Fe3+-induced amyloid beta (1 to 42) (unknown origin) preformed fibrils assessed as remaining amyloid beta aggregation level at 75 mM after 24 hrs by thioflavin-T fluorescence assay | 2018 | Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22 | Resveratrol-maltol hybrids as multi-target-directed agents for Alzheimer's disease. |
| AID359533 | Effect on secreted acidic cysteine rich glycoprotein gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1220762 | Clearance in C57BL/6 mouse at 15 mg/kg administered intraarterially by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Oct, Volume: 40, Issue:10 | In vivo-formed versus preformed metabolite kinetics of trans-resveratrol-3-sulfate and trans-resveratrol-3-glucuronide. |
| AID416673 | Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Synthesis and biological evaluation of cytotoxic properties of stilbene-based resveratrol analogs. |
| AID1054847 | Inhibition of human recombinant TTR Y78F mutant-mediated fibrillogenesis at 40 uM after 30 mins by turbidimetric assay relative to control | 2013 | Journal of medicinal chemistry, Nov-27, Volume: 56, Issue:22 | Modulation of the fibrillogenesis inhibition properties of two transthyretin ligands by halogenation. |
| AID1430687 | Apparent clearance in Wistar rat at 20 mg/kg, po by HPLC-MS analysis | 2017 | ACS medicinal chemistry letters, May-11, Volume: 8, Issue:5 | Toward Resolving the Resveratrol Conundrum: Synthesis and |
| AID406773 | DPPH radical scavenging activity at 50 uM | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | Efficient synthesis and neuroprotective effect of substituted 1,3-diphenyl-2-propen-1-ones. |
| AID359066 | Effect on scavenger receptor B2 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID491621 | Inhibition of TNF-alpha-induced NF-kappaB activity expressed in HEK293 cells at 34 uM after 48 hrs by luciferase reporter gene assay relative to control | 2010 | Journal of medicinal chemistry, Jul-08, Volume: 53, Issue:13 | Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. |
| AID587229 | Inhibition of human quinone reductase 2 expressed in Escherichia coli BL21(DE3) assessed as N-methyldihydronicotinamide oxidation per mg of protein after 1 hr by LC-MS analysis analysis | 2011 | Journal of natural products, Feb-25, Volume: 74, Issue:2 | Bioactive compounds from the fern Lepisorus contortus. |
| AID1362634 | Metal chelating activity assessed as compound-Cu2+ adduct formation at 20 uM by spectrophotometric titration analysis | |||
| AID359302 | Increase in bone morphogenetic protein 2 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID654122 | Antioxidant activity assessed as scavenging of superoxide anions after 10 mins by spectrophotometry | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8 | Free radical scavenging and antiproliferative properties of Biginelli adducts. |
| AID738198 | Inhibition of Stat3 signaling pathway in human HeLa cells assessed as measured as lowest concentration required 50 to 60 % inhibition of IL-6 induced luciferase treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID528473 | Binding affinity to amyloid beta (1 to 40) in APP/PS1 transgenic mouse brain by fluorescence titration analysis | 2010 | Journal of medicinal chemistry, Nov-25, Volume: 53, Issue:22 | Phenolic bis-styrylbenzenes as β-amyloid binding ligands and free radical scavengers. |
| AID1065384 | Antimicrobial activity against Salmonella typhimurium after 24 hrs by microbroth dilution method | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Small azobenzene derivatives active against bacteria and fungi. |
| AID749801 | Antiproliferative activity against BAEC after 3 days by MTT assay | 2013 | Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11 | Inhibition of VEGF expression in cancer cells and endothelial cell differentiation by synthetic stilbene derivatives. |
| AID1879021 | Antifibrotic activity in CCL-4 induced liver fibrosis C57/B6J mouse model transfected with miR-190a-5p agomir assessed as increase in HGF expression at 100 mg/kg/day, ip measured after 72 hrs post last dose by Western blot analysis | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID416366 | Cytotoxicity against human HL60 cells at 30 uM after 48 hrs by MTT assay | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6 | 4,4'-Dihydroxy-trans-stilbene, a resveratrol analogue, exhibited enhanced antioxidant activity and cytotoxicity. |
| AID294482 | Cytotoxicity against mouse Hepa 1c1c7 cells assessed as cell viability at 25 uM after 24 hrs by MTT assay | 2007 | European journal of medicinal chemistry, Jun, Volume: 42, Issue:6 | Quinone reductase induction activity of methoxylated analogues of resveratrol. |
| AID549852 | Cytotoxicity against mouse HT22 cells assessed as cell viability at 1 uM after 3 days by LDH release assay relative to control | 2011 | Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1 | New hydroxystilbenoid derivatives endowed with neuroprotective activity and devoid of interference with estrogen and aryl hydrocarbon receptor-mediated transcription. |
| AID359312 | Effect on CD36 antigen gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID639320 | Antibacterial activity against CagA-expressing Helicobacter pylori MD6 isolated from chronic gastritis patient after 24 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID459814 | Inhibition of human recombinant NQO2 by spectrophotometry | 2010 | Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2 | Triazoloacridin-6-ones as novel inhibitors of the quinone oxidoreductases NQO1 and NQO2. |
| AID1372020 | Antioxidant activity assessed as Trolox equivalents of photolysis-induced methyl radical scavenging activity using DMPO spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID359084 | Increase in osteocalcin levels in rat primary osteoblast cells at 1 uM after 72 hrs by ELISA | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID365325 | Activity for Streptomyces coelicolor A3(2) prenyltransferase assessed as formation of 5-(4-hydroxystyryl)-2-((E)-3,7-dimethylocta-2,6-dienyl)benzene-1,3-diol | 2008 | Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17 | Chemoenzymatic syntheses of prenylated aromatic small molecules using Streptomyces prenyltransferases with relaxed substrate specificities. |
| AID1362756 | Antiinflammatory activity in Balb/c mouse ear edema model assessed as inhibition of croton oil-induced ear edema at 0.1 mg/ear administered topically immediately post croton oil treatment and measured after 4 hrs relative to control | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues. |
| AID692946 | Inhibition of Wnt/beta-casein in human LS174T cells assessed as reduction in c-Myc mRNA level at 100 uM after 36 hrs by RT-PCR analysis | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID377455 | Estrogenic activity in human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol by alamar blue assay | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3 | Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines. |
| AID1261079 | Cytotoxicity against HEK293 cells assessed inhibition of cell proliferation after 2 days by MTT assay | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Inhibitory effect of cytotoxic stilbenes related to resveratrol on the expression of the VEGF, hTERT and c-Myc genes. |
| AID1872756 | Antioxidant activity assessed as Fe2+/ascorbate-induced MDA level in liver mitochondria (unknown origin) preincubated for 30 mins followed by addition of Fe2+/ascorbate measured after 30 mins | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy. |
| AID726368 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by spectrophotometry | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Antioxidant activities of thiosemicarbazones from substituted benzaldehydes and N-(tetra-O-acetyl-β-D-galactopyranosyl)thiosemicarbazide. |
| AID1173640 | Antiproliferative activity against human COLO205 cells by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23 | Synthesis and antiproliferative evaluation of 2-hydroxylated (E)-stilbenes. |
| AID1354542 | Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced MCP1 expression after 24 hrs by ELISA | 2018 | Journal of natural products, 05-25, Volume: 81, Issue:5 | Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner. |
| AID1519070 | Antimelanogenic activity against C57BL/6 mouse B16F10 cells at 50 uM incubated for 72 hrs relative to control | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | From bench to counter: Discovery and validation of a peony extract as tyrosinase inhibiting cosmeceutical. |
| AID692941 | Cytotoxicity against human HCT116 cells at 10 uM for 2 days by vi-cell cell viability analysis | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID1571124 | Antioxidant activity assessed as trolox equivalents of AAPH radical scavenging activity at 20 uL preincubated for 10 mins followed by AAPH addition measured every min for 120 mins by ORAC-FL assay | 2018 | MedChemComm, Nov-01, Volume: 9, Issue:11 | Discovery of boron-containing compounds as Aβ aggregation inhibitors and antioxidants for the treatment of Alzheimer's disease. |
| AID1210972 | AUC (0 to infinity) in C57BL/6 mouse at 15 mg/kg, iv | 2013 | Drug metabolism and disposition: the biological fate of chemicals, May, Volume: 41, Issue:5 | Pulmonary metabolism of resveratrol: in vitro and in vivo evidence. |
| AID1328101 | Neuroprotective activity in human SK-N-SH cells assessed as inhibition of glutamate-induced injury by measuring cell survival at 10 uM preincubated for 4 hrs followed by glutamate addition measured after 4 hrs by MTT assay relative to control | 2016 | Journal of natural products, 08-26, Volume: 79, Issue:8 | Regiospecific Prenylation of Hydroxyxanthones by a Plant Flavonoid Prenyltransferase. |
| AID1826665 | Inhibition of human recombinant MAO-B using tyramine as substrate by fluorescence assay | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades. |
| AID1884102 | Hemolytic activity in human erythrocytes at 128 uM incubated for 1 hrs | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID365338 | Ratio of Kcat to Km of Streptomyces coelicolor A3(2) prenyltransferase assessed as formation of 5-(4-hydroxystyryl)-2-((E)-3,7-dimethylocta-2,6-dienyl)benzene-1,3-diol | 2008 | Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17 | Chemoenzymatic syntheses of prenylated aromatic small molecules using Streptomyces prenyltransferases with relaxed substrate specificities. |
| AID692956 | Cytotoxicity against human SW480 cells at 10 uM for 4 days by vi-cell cell viability analysis | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID638148 | Bactericidal activity against CagA-deficient Helicobacter pylori NS23 isolated from chronic gastritis patient compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1309171 | Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins by spectrophotometry | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Ionophoric polyphenols selectively bind Cu(2+), display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila. |
| AID667226 | Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents. |
| AID1647484 | Inhibition of PTP1B (unknown origin) assessed as decrease in p-nitrophenolate formation using using pNPP as substrate by Dixon plot analysis | 2020 | Journal of natural products, 02-28, Volume: 83, Issue:2 | Stilbenes with Potent Protein Tyrosine Phosphatase-1B Inhibitory Activity from the Roots of |
| AID1609868 | Inhibition of SGK1 in human HuH7 cells assessed as reduction in insulin-induced MDM2 phosphorylation on Ser166 at 100 uM incubated for 6 hrs by Western blot analysis | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Review about the multi-target profile of resveratrol and its implication in the SGK1 inhibition. |
| AID1238815 | Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth after 24 hrs by MTT assay | 2015 | Journal of medicinal chemistry, Aug-27, Volume: 58, Issue:16 | Novel Resveratrol-Based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer Activity. |
| AID1309178 | Inhibition of self-induced amyloid beta (1 to 40) (unknown origin) fibril aggregation assessed as remaining fibril aggregates at 100 uM after 3 days at pH 6.60 by thioflavin-T fluorescence assay | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Ionophoric polyphenols selectively bind Cu(2+), display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila. |
| AID1371465 | Induction of DOPC/n-decane bilayer property changes assessed as concentration required to double gramicidin-induced quencher influx rate by single-channel electrophysiology method | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1632205 | Cytotoxicity against human MHRF cells after 72 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18 | Synthesis and anticancer activity of a hydroxytolan series. |
| AID1298409 | Potentiation of 5-Aza-dC-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as increase in frequency of G to C transversion at 50 uM incubated for 4 hrs preinfection followed by 5-Aza-C addition for | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1347865 | Antioxidant activity assessed as ABTS radical scavenging activity at 25 uM after 15 mins | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, synthesis and evaluation of novel dihydrostilbene derivatives as potential anti-melanogenic skin-protecting agents. |
| AID359105 | Increase in BMP2 mRNA levels in rat primary osteoblast cells at 1 uM by RT-PCR method | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1173643 | Antiproliferative activity against human MGC803 cells by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23 | Synthesis and antiproliferative evaluation of 2-hydroxylated (E)-stilbenes. |
| AID1371454 | Plasma concentration in mouse at 100 mg/kg, po at 60 mins by LC-MS/MS method | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID264601 | Induction of differentiation of human HL60 cells at 10 uM measured as expression of granulocytic marker CD11c after 4 days | 2006 | Journal of medicinal chemistry, May-18, Volume: 49, Issue:10 | Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. |
| AID638060 | Bactericidal activity against CagA-deficient Helicobacter pylori G50 isolated from chronic gastritis patient compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID287091 | Cytotoxicity against human KB cells after 48 hrs | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Synthesis and cytotoxic evaluation of a series of resveratrol derivatives modified in C2 position. |
| AID1298429 | Antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as Gag mutation at 50 uM incubated for 4 hrs prior to infection measured at 72 hrs post infection by illumina sequencing method (Rvb = 18.4%) | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID493982 | Inhibition of mushroom tyrosinase | 2010 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 20, Issue:16 | A newly synthesized, potent tyrosinase inhibitor: 5-(6-hydroxy-2-naphthyl)-1,2,3-benzenetriol. |
| AID247275 | In vitro growth inhibitory concentration against human colon cancer cell line HCT 116 | 2005 | Journal of medicinal chemistry, Feb-24, Volume: 48, Issue:4 | Synthesis, antitumor evaluation, and apoptosis-inducing activity of hydroxylated (E)-stilbenes. |
| AID432151 | Inhibition of heat killed Escherichia coli K12-induced NF-kappaB activation in HEK293 cells expressing TLR2 pretreated for 1 hr before 6 hrs heat killed bacterial stimulation by luciferase reporter gene assay | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID725750 | Cytotoxicity against human T47D cells by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 23, Issue:3 | Novel Aza-resveratrol analogs: synthesis, characterization and anticancer activity against breast cancer cell lines. |
| AID359065 | Effect on procollagen 4 alpha 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID359499 | Effect on fibroblast growth factor receptor 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID638057 | Antibacterial activity against CagA-expressing Helicobacter pylori 3Cb isolated from gastric carcinoma patient after 48 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1428606 | Binding affinity to Cu2+ assessed as disaggregation of Cu2+-induced amyloid beta (1 to 42) aggregation by measuring Cu2+-amyloid beta (1 to 42) complex fluorescence at 75 uM treated 24 hrs after Cu2+ addition measured after 24 hrs incubation under dark co | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Synthesis and biological evaluation of deferiprone-resveratrol hybrids as antioxidants, Aβ |
| AID1884067 | Antibacterial activity against Clostridium perfringens CECT376 incubated for 24 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID132501 | Inhibitory activity against nitric oxide production in LPS-activated mouse peritoneal macrophages | 2000 | Bioorganic & medicinal chemistry letters, Feb-21, Volume: 10, Issue:4 | Effects of stilbene constituents from rhubarb on nitric oxide production in lipopolysaccharide-activated macrophages. |
| AID639325 | Antibacterial activity against CagA-expressing Helicobacter pylori G39 isolated from chronic gastritis patient after 24 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1437808 | Hepatotoxicity against human HepG2 cells assessed as decrease in cell viability at 5 to 50 uM after 24 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease. |
| AID1347858 | Inhibition of tyrosinase in mouse B16 cells assessed as effect on alpha-MSH-induced melanin formation at 25 uM after 24 hrs relative to control | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, synthesis and evaluation of novel dihydrostilbene derivatives as potential anti-melanogenic skin-protecting agents. |
| AID719266 | Antioxidant activity of compound assessed as DPPH radical scavenging activity | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1). |
| AID738186 | Inhibition of Myc signaling pathway in human HeLa cells assessed as measured as lowest concentration required 50 to 60 % inhibition of PMA induced luciferase treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID1609876 | Induction of apoptosis in human HuH7 cells transfected with ShSGK1 assessed as early apoptosis at 100 uM incubated for 48 hrs by annexin V and 7-AAD staining based assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Review about the multi-target profile of resveratrol and its implication in the SGK1 inhibition. |
| AID1437789 | Inhibition of acetylcholinesterase isolated from human red blood cells at 10 uM using acetylthiocholine as substrate preincubated for 5 mins followed by substrate addition measured every 2 mins by Ellman's method | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease. |
| AID432157 | Inhibition of heat killed Staphylococcus aureus 209P-induced TNF alpha production in mouse RAW264.7 cells at 1 to 100 uM after 6 hrs by ELISA | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID510194 | Vasorelaxant activity in Wistar rat aortic rings assessed as reduction in KCL-induced contractile tone in presence of tetraethylammonium chloride | 2010 | Bioorganic & medicinal chemistry, Sep-15, Volume: 18, Issue:18 | Synthesis of heterocycle-based analogs of resveratrol and their antitumor and vasorelaxing properties. |
| AID359187 | Inhibition of [14C]dehydroascorbic acid uptake in human U937 cells by scintillation spectrometry in presence of sodium-free buffer | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3 | Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells. |
| AID1173642 | Antiproliferative activity against human HT-29 cells by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23 | Synthesis and antiproliferative evaluation of 2-hydroxylated (E)-stilbenes. |
| AID719268 | Inhibition of LPS-induced iNOS activity in mouse RAW 264.7 cells assessed as inhibition of NO production at 50 uM pretreated with compound for 30 mins before LPS challenge after 24 hrs by Griess reagent method | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1). |
| AID699925 | Antiviral activity against HIV1 infected in human U373-MAGI cells expressing CXCR4 assessed as infected host cells at 20 uM preincubated for 2 hrs prior to infection followed by compound wash out post infection measured after 48 hrs by single round replic | 2012 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 22, Issue:21 | Anti-HIV-1 activity of resveratrol derivatives and synergistic inhibition of HIV-1 by the combination of resveratrol and decitabine. |
| AID674916 | Antioxidant activity assessed as singlet 1O2 oxygen quenching activity after 2 mins by EPR spectrometry | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17 | The antioxidant effect of imine resveratrol analogues. |
| AID1203661 | Induction of apoptosis in human Bel7402 cells assessed as detection error cells at 50 uM after 48 hrs by flow cytometry (Rvb = 0.43%) | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Design, synthesis, and biological evaluation of benzoselenazole-stilbene hybrids as multi-target-directed anti-cancer agents. |
| AID1420925 | Antibacterial activity against Arcobacter butzleri after 17 hrs by NCCLS broth microdilution method | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Antibacterial and antioxidant activities for natural and synthetic dual-active compounds. |
| AID1632227 | Pro-oxidative activity in human DU145 cells assessed as increase in H2O2 mediated DCF formation at 25 to 100 uM preincubated with DCFH-DA for 30 mins followed by compound treatment for 3 hrs by fluorescence analysis | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18 | Synthesis and anticancer activity of a hydroxytolan series. |
| AID432164 | Inhibition of phagocytosis of heat killed FITC-conjugated Escherichia coli K12 in HEK293 at 100 uM by after 1 hr | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID501907 | Inhibition of human carbonic anhydrase 5a after 15 mins by stopped flow CO2 hydration method | 2010 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17 | Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. |
| AID284121 | Antiamyloidogenic activity assessed as inhibition of beta amyloid (25-35) fibril formation after 6 hrs | 2007 | Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2 | Inhibitory activity of stilbenes on Alzheimer's beta-amyloid fibrils in vitro. |
| AID403341 | Inhibition of COX1 | 2005 | Journal of natural products, Jul, Volume: 68, Issue:7 | Expanding the ChemGPS chemical space with natural products. |
| AID1879012 | Downregulation of miR-190a-5p expression in TGF-beta induced C57/B6J mouse primary hepatocytes in presence of miR-190a-5p mimic incubated for 4 hrs by qRT-PCR analysis | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID359319 | Effect on procollagen 4 alpha 4 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1168359 | Hepatoprotective activity against isoniazid-rifampicin induced liver injury in BALB/c mouse assessed as reduction in hepatic lesion at 100 mg/kg, po bid for 3 days starting 30 mins prior isoniazid-rifampicin administration measured 24 hrs post-last dose o | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. |
| AID719269 | Inhibition of TNFalpha-induced NF-kappaB activity expressed in HEK293 cells by luciferase reporter gene assay | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1). |
| AID359186 | Inhibition of [14C]dehydroascorbic acid uptake in human U937 cells by Michaelis-Menten plot | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3 | Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells. |
| AID1705585 | Cytoprotective activity against H2O2-induced cell death in human PC-12 cells assessed as cell viability at 10 uM incubated for 0.5 hrs followed by H2O2 stimulation and measured after 2 hrs by MTT assay | 2020 | European journal of medicinal chemistry, Dec-01, Volume: 207 | Preparation, characterization, antioxidant evaluation of new curcumin derivatives and effects of forming HSA-bound nanoparticles on the stability and activity. |
| AID1298440 | Potentiation of 5-Aza-dC-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as Pol mutation at 50 uM incubated for 4 hrs preinfection followed by 5-Aza-C addition for 2 hrs preinfection and subseque | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1188902 | Inhibition of recombinant firefly luciferase at 0.0001 to 100 uM by absorption spectroscopy in presence of varying concentration of D-luciferin | 2014 | ACS medicinal chemistry letters, Aug-14, Volume: 5, Issue:8 | Total Synthesis and Biological Studies of TMC-205 and Analogues as Anticancer Agents and Activators of SV40 Promoter. |
| AID510193 | Vasorelaxant activity in Wistar rat aortic rings assessed as reduction in KCL-induced contractile tone at 30 uM | 2010 | Bioorganic & medicinal chemistry, Sep-15, Volume: 18, Issue:18 | Synthesis of heterocycle-based analogs of resveratrol and their antitumor and vasorelaxing properties. |
| AID1314127 | Toxicity in rat thymocytes assessed as increase in cell death at 100 uM measured after 4 hrs by flow cytometric analysis relative to control | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | A facile and rapid access to resveratrol derivatives and their radioprotective activity. |
| AID1060591 | Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins by spectrophotometric analysis | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Design, synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer's disease. |
| AID1298336 | Reduction in dRGU-TP level in human U373-MAGI cells at 200 uM preincubated for 2 hrs followed by 5-aza-C addition measured after 4 hrs by LC-MS/MS analysis | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID432141 | Inhibition of phagocytosis of FITC-conjugated Staphylococcus aureus 209P in mouse RAW264.7 cells assessed as reduction in ratio of number of bacterial cells to phagocytes using trypan blue staining by flow cytometry | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID501906 | Inhibition of human carbonic anhydrase 4 after 15 mins by stopped flow CO2 hydration method | 2010 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17 | Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. |
| AID1306407 | Upregulation of SIRT-1 gene expression in human epidermal full thickness skin cultures at 1 % after 24 hrs by real time PCR analysis relative to control | 2016 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 26, Issue:14 | Synthesis and skin gene analysis of 4'-acetoxy-resveratrol (4AR), therapeutic potential for dermal applications. |
| AID1435566 | Inhibition of recombinant full length LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE) using H3K4me2 substrate at 10 uM by fluorescence assay | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Discovery of resveratrol derivatives as novel LSD1 inhibitors: Design, synthesis and their biological evaluation. |
| AID1573651 | Activation of Nrf2 in rat HBZY-1 cells assessed as increase in NQO-1 mRNA expression at 6 uM after 24 hrs by RT-PCR analysis | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and biological evaluation of bifendate derivatives bearing acrylamide moiety as novel antioxidant agents. |
| AID639332 | Antibacterial activity against CagA-expressing Helicobacter pylori 4Cb isolated from gastric carcinoma patient after 24 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID637949 | Antibacterial activity against CagA-expressing Helicobacter pylori 3Cb isolated from gastric carcinoma patient after 24 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID639244 | Antibacterial activity against CagA-deficient Helicobacter pylori 328 KM isolated from chronic gastritis patient after 24 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1676792 | Induction of membrane perturbation in DC22:1PC LUV bilayer assessed as fluorescence quench rate by measuring gramicidin mixture monomer to dimer equilibrium at 30 uM by fluorescence quenching assay | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20 | Assessing the Perturbing Effects of Drugs on Lipid Bilayers Using Gramicidin Channel-Based |
| AID639245 | Antibacterial activity against CagA-deficient Helicobacter pylori G12 isolated from chronic gastritis patient after 24 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1198741 | Inhibition of Saccharomyces cerevisiae alpha-glucosidase | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93 | Antioxidant activity and inhibition of α-glucosidase by hydroxyl-functionalized 2-arylbenzo[b]furans. |
| AID1203663 | Induction of apoptosis in human Bel7402 cells assessed as apoptotic cells at 50 uM after 48 hrs by flow cytometry (Rvb = 0.73%) | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Design, synthesis, and biological evaluation of benzoselenazole-stilbene hybrids as multi-target-directed anti-cancer agents. |
| AID147031 | The minimum inhibitory concentration (MIC) that inhibits all visible growth of the Neisseria gonorrhoeae (bacteria) | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID1306411 | Upregulation of elastin gene expression in human epidermal full thickness skin cultures at 1 % after 24 hrs by real time PCR analysis relative to control | 2016 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 26, Issue:14 | Synthesis and skin gene analysis of 4'-acetoxy-resveratrol (4AR), therapeutic potential for dermal applications. |
| AID1632218 | Selectivity index, ratio of CD50 against human MHRF cells to CD50 for human DU145 cells after 24 hrs | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18 | Synthesis and anticancer activity of a hydroxytolan series. |
| AID455036 | Cytotoxicity against human KM20L2 cells after 48 hrs by sulforhodamine B assay | 2009 | Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18 | E-Combretastatin and E-resveratrol structural modifications: antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes. |
| AID713096 | Inhibition of mushroom tyrosinase-mediated L-DOPA oxidation assessed as decrease in dopachrome formation at 100 uM incubated 30 mins prior to substrate addition measured after 60 mins by UV-vis spectrophotometric analysis | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID1347863 | Inhibition of alpha-MSH-induced TRP-1 expression in human A375 cells at 25 uM after 24 hrs by Western blot method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, synthesis and evaluation of novel dihydrostilbene derivatives as potential anti-melanogenic skin-protecting agents. |
| AID359295 | Reduction in anchorage-independent colony formation of human MDA-MB-231 cells at 1 uM by soft agar colony forming assay | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1261107 | Down regulation of c-Myc gene expression in human MCF7 cells at 10 ug/mL after 48 hrs by RT-qPCR analysis relative to control | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Inhibitory effect of cytotoxic stilbenes related to resveratrol on the expression of the VEGF, hTERT and c-Myc genes. |
| AID1423291 | Neuroprotective activity against glutamate-induced toxicity in human SK-N-SH cells assessed as cell viability at 10 uM pretreated for 4 hrs followed by glutamate challenge measured after 4 hrs by MTT assay (Rvb = 67.7 +/- 1.1%) | 2018 | Journal of natural products, 11-26, Volume: 81, Issue:11 | Methylated Polycyclic Polyprenylated Acylphloroglucinol Derivatives from Hypericum ascyron. |
| AID359509 | Effect on integrin alpha 2b gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1331318 | Antioxidant activity assessed as inhibition of peroxyl radical-induced oxidation at 10 uM by ORAC assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2 | Synthesis and application of β-carbolines as novel multi-functional anti-Alzheimer's disease agents. |
| AID359069 | Reversal of induction in nuclear translocation of ERalpha in mouse MC3T3-E1 cells transfected with dominant-negative mutant Src expression vector at 1 uM | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID761463 | Inhibition of amyloid beta (1-42) self-mediated aggregation (unknown origin) after 5 days by thioflavin T fluorescence method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase. |
| AID1278611 | Antiinflammatory activity in carrageenan-induced BALB/c mouse paw edema model assessed as decrease in paw volume at 10 mg/kg, po administered 30 mins prior to carrageenan challenge measured after 6 hrs by plethysmometric analysis relative to control | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog. |
| AID1498850 | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 2 mins followed by substrate addition and measured after 2 mins by Ellman's method | 2018 | Bioorganic & medicinal chemistry, 07-30, Volume: 26, Issue:13 | Design, synthesis and evaluation of novel bivalent β-carboline derivatives as multifunctional agents for the treatment of Alzheimer's disease. |
| AID1467686 | Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx at 10 uM preincubated for 6 mins followed by AITC addition measured for 1 min by Fluo-4 dye-based assay relative to control | 2017 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14 | Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor. |
| AID738177 | Inhibition of Wnt signaling pathway in human HeLa cells assessed as inhibition of Wnt3a induced luciferase treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID1884056 | Antibacterial activity against Enterococcus faecalis LMG 16216 incubated for 20 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID359332 | Effect on colony stimulating factor 2 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID719276 | Induction of quinone reductase-1 activity in mouse Hepa-1c1c7 cells assessed as induction ratio after 48 hrs by MTT assay relative to control | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1). |
| AID432136 | Inhibition of phagocytosis of FITC-conjugated Escherichia coli K12 in human THP1 cells using trypan blue staining after 20 mins by flow cytometry | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID458148 | Antimicrobial activity against Streptococcus sanguinis NCTC 9811 at 400 ug/ml after 20 hrs by disk diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | The antimicrobial activity of compounds from the leaf and stem of Vitis amurensis against two oral pathogens. |
| AID1062134 | Antibiofilm activity against Escherichia coli O157:H7 assessed as repression of csgG expression at 20 ug/ml after 5 hrs by qRT-PCR analysis | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1 | Resveratrol oligomers inhibit biofilm formation of Escherichia coli O157:H7 and Pseudomonas aeruginosa. |
| AID1070113 | Allosteric modulation of rat GABAA alpha1beta2gamma2S receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride ion current at holding potential -70 mV at 100 uM by two-microelectrode voltage clamp assay relative to GA | 2014 | Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4 | Identification of dihydrostilbenes in Pholidota chinensis as a new scaffold for GABAA receptor modulators. |
| AID1884074 | Bactericidal activity against Bacillus cereus ATCC 10987 at 128 uM measured upto 24 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID1420919 | Antibacterial activity against Listeria monocytogenes after 17 hrs by NCCLS broth microdilution method | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Antibacterial and antioxidant activities for natural and synthetic dual-active compounds. |
| AID82982 | In vitro inhibitory concentration against proliferation of HL60 cells | 2003 | Journal of medicinal chemistry, Jul-31, Volume: 46, Issue:16 | Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents. |
| AID1306442 | Inhibition of recombinant human CYP1B1 expressed in Escherichia coli DH5aplha cells assessed as O-deethylation of ethoxyresorufin in presence of NADPH at 100 uM measured after 2 mins by spectrofluorometric method | 2016 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 26, Issue:14 | Aryl morpholino triazenes inhibit cytochrome P450 1A1 and 1B1. |
| AID638061 | Bactericidal activity against CagA-deficient Helicobacter pylori G21b isolated from chronic gastritis patient compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1333788 | Cytotoxicity against human HCT116 cells assessed as cell growth inhibition at 100 uM after 48 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1 | Synthesis and bioactivity evaluation of 2,3-diaryl acrylonitrile derivatives as potential anticancer agents. |
| AID359282 | Reversal of increase in ER.DNA complex in mouse MC3T3-E1 cells expressing small interfering RNA for FOXA1 protein at 1 uM by RT-PCR | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1261096 | Down regulation of hTERT gene expression in human HT-29 cells at 10 ug/mL after 48 hrs by RT-qPCR analysis relative to control | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Inhibitory effect of cytotoxic stilbenes related to resveratrol on the expression of the VEGF, hTERT and c-Myc genes. |
| AID491526 | Inhibition of quinone reductase 1 in mouse Hepa 1c1c7 cells assessed as drug level required to double enzyme activity by MTT assay | 2010 | Journal of medicinal chemistry, Jul-08, Volume: 53, Issue:13 | Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. |
| AID637965 | Antibacterial activity against CagA-expressing Helicobacter pylori Ma01 isolated from chronic gastritis patient after 48 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID617269 | Radioprotective activity against 9.75 Gy gamma radiation-induced death in C57BL/6NHsd mouse assessed as increase in survival rate at 1 mg/kg, ip administered 10 mins prior to irradiation | 2011 | ACS medicinal chemistry letters, Jan-25, Volume: 2, Issue:4 | The Use of 3,5,4'-Tri-O-acetylresveratrol as a Potential Pro-drug for Resveratrol Protects Mice from γ-Irradiation-Induced Death. |
| AID638153 | Bactericidal activity against CagA-expressing Helicobacter pylori MDO21 isolated from chronic gastritis patient compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1420928 | Antioxidant activity assessed as ABTS radical scavenging activity by measuring trolox equivalence of antioxidant capacity at 1 uM up to 24 hrs by spectrophotometric analysis | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Antibacterial and antioxidant activities for natural and synthetic dual-active compounds. |
| AID1298348 | Antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as increase in frequency of C to A transversion at 50 uM incubated for 4 hrs prior to infection measured at 72 hrs post infection by illumina sequencing me | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1608144 | Binding affinity to Keap1 in rat HBZY-1 cells assessed as induction of Nrf2 nuclear translocation by measuring increase in ratio of nuclear to cytosolic Nrf2 level by Western blot analysis | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Synthesis and assessment of phenylacrylamide derivatives as potential anti-oxidant and anti-inflammatory agents. |
| AID420376 | Inhibition of ionomycin-stimulated LTB4 production in human whole blood treated 15 mins prior to ionomycin challenge measured after 30 mins of stimulation by enzyme-linked immunosorbent assay | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15 | Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. |
| AID1083154 | Antifungal activity against Diplodia seriata BoF98-1 assessed as growth inhibition measured after 1 to 10 days | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID331051 | Activation of human SIRT1-E (225-664) construct by mass spectrometry assay relative to control | 2007 | Nature, Nov-29, Volume: 450, Issue:7170 | Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. |
| AID1632196 | Cytotoxicity against human MDAH 2774 cells after 24 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18 | Synthesis and anticancer activity of a hydroxytolan series. |
| AID1557207 | Antibiofilm activity against Streptococcus mutans assessed as inhibition of biofilm formation | 2019 | MedChemComm, Jul-01, Volume: 10, Issue:7 | Targeting |
| AID1662942 | Antioxidant activity assessed as DPPH radical scavenging activity by spectrophotometric analysis | 2020 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 30, Issue:13 | Synthesis, biological evaluation of benzothiazole derivatives bearing a 1,3,4-oxadiazole moiety as potential anti-oxidant and anti-inflammatory agents. |
| AID455041 | Inhibition of tubulin polymerization | 2009 | Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18 | E-Combretastatin and E-resveratrol structural modifications: antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes. |
| AID432163 | Inhibition of DC-SIGN expression in HEK293 cells expressing DC-SIGN at 100 uM by Western blot analysis | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID977602 | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID404304 | Effect on human MRP2-mediated estradiol-17-beta-glucuronide transport in Sf9 cells inverted membrane vesicles relative to control | 2008 | Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11 | Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). |
| AID388250 | Antiproliferative activity against human CNE1 cells after 72 hrs by MTT assay | 2008 | Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23 | The design, synthesis, and anti-tumor mechanism study of N-phosphoryl amino acid modified resveratrol analogues. |
| AID1552788 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS/IFNgamma-induced NO production by measuring NO level preincubated for 2 hrs and followed by LPS/IFNgamma addition and measured after 24 hrs by Griess assay | 2019 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 29, Issue:17 | Comparative analysis of stilbene and benzofuran neolignan derivatives as acetylcholinesterase inhibitors with neuroprotective and anti-inflammatory activities. |
| AID608336 | Antibacterial activity against 1 x 10'4 cfu/mL methicillin-resistant Staphylococcus aureus ATCC 700699 after 24 hrs by NCCLS M7-A6 microtiter broth dilution method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis and antimicrobial evaluation of new benzofuran derivatives. |
| AID617268 | Radioprotective activity against 9.75 Gy gamma radiation-induced death in C57BL/6NHsd mouse assessed as survival rate at 10 mg/kg, ip administered 10 mins prior to irradiation | 2011 | ACS medicinal chemistry letters, Jan-25, Volume: 2, Issue:4 | The Use of 3,5,4'-Tri-O-acetylresveratrol as a Potential Pro-drug for Resveratrol Protects Mice from γ-Irradiation-Induced Death. |
| AID770333 | Inhibition of human quinone reductase 2 expressed in Escherichia coli BL21(DE3) using N-methyldihydronicotinamide as co-substrate | 2013 | Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19 | Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2. |
| AID1362742 | Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability at >= 100 uM after 48 hrs by MTT assay | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues. |
| AID359064 | Effect on procollagen 8 alpha 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1878984 | Inhibition of TGF-beta1 induced apoptosis in C57/B6J mouse primary hepatocytes assessed as late apoptotic cells at 10 uM by Annexin-V-FITC-H and PI staining based flow cytometry analysis (Rvb = 12.12 %) | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID637957 | Antibacterial activity against CagA-deficient Helicobacter pylori 328 KM isolated from chronic gastritis patient after 48 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1362645 | Inhibition of self-induced amyloid beta (1 to 40) (unknown origin) fibril aggregation assessed as aggregation level at 100 uM measured on day 3 by UV-visible turbidity method (Rvb = 100 +/- 0.14%) | |||
| AID1632223 | Selectivity index, ratio of CD50 against human MHRF cells to CD50 for human MDAH 2774 cells after 48 hrs | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18 | Synthesis and anticancer activity of a hydroxytolan series. |
| AID1062140 | Antimicrobial activity against Escherichia coli O157:H7 by spectrophotometry | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1 | Resveratrol oligomers inhibit biofilm formation of Escherichia coli O157:H7 and Pseudomonas aeruginosa. |
| AID1372033 | Antioxidant activity assessed as rate constant for singlet oxygen scavenging activity in aqueous solution by EPR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID1383209 | Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced IL-1beta production after 24 hrs by ELISA | 2018 | European journal of medicinal chemistry, Apr-10, Volume: 149 | Design, synthesis, and biological evaluation of compounds with a new scaffold as anti-neuroinflammatory agents for the treatment of Alzheimer's disease. |
| AID667228 | Cytotoxicity against human A253 cells after 96 hrs by SRB assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents. |
| AID1298384 | Reduction in 5-aza-dCTP level in human U373-MAGI cells at 200 uM preincubated for 2 hrs followed by 5-aza-C addition measured after 4 hrs by LC-MS/MS analysis | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID402269 | Antioxidant activity against beta-carotene and linoleic acid assessed as inhibition of bleaching of beta-carotene at 120 mins by autooxidation assay | 2004 | Journal of natural products, May, Volume: 67, Issue:5 | Yucca schidigera bark: phenolic constituents and antioxidant activity. |
| AID482994 | Inhibition of amyloid beta 25-35 fibril formation at 10 uM by using UV-visible measurements and electron microscopy analysis | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11 | New stilbene dimers against amyloid fibril formation. |
| AID1424461 | Inhibition of recombinant human PAK1 by ADP-Glo kinase assay | 2017 | European journal of medicinal chemistry, Dec-15, Volume: 142 | From bench (laboratory) to bed (hospital/home): How to explore effective natural and synthetic PAK1-blockers/longevity-promoters for cancer therapy. |
| AID1676772 | Induction of membrane perturbation in DC18:1PC LUV bilayer assessed as effect on potential of mean force by measuring reduction in deltaG for gramicidin mixture monomer to dimer and pure gramicidin-bilayer by fluorescence quenching assay | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20 | Assessing the Perturbing Effects of Drugs on Lipid Bilayers Using Gramicidin Channel-Based |
| AID713109 | Activation of mushroom tyrosinase assessed as dopachrome formation after 60 mins by UV-vis spectrophotometric analysis | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID420373 | Solubility in methanol | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15 | Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. |
| AID638049 | Antibacterial activity against CagA-expressing Helicobacter pylori G39 isolated from chronic gastritis patient after 48 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID434720 | Antioxidant activity assessed as DPPH radical scavenging activity | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Synthesis of novel trans-stilbene derivatives and evaluation of their potent antioxidant and neuroprotective effects. |
| AID359076 | Increase in ALP activity in mouse MC3T3-E1 cells at 0.1 to 10 uM after 7 days | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID614080 | Antibacterial activity against Bacillus brevis ATTC 9999 at 10 mg/ml after 24 to 72 hrs by agar diffusion method | 2011 | Bioorganic & medicinal chemistry, Sep-01, Volume: 19, Issue:17 | Synthesis and antimicrobial activity of (E) stilbene derivatives. |
| AID719277 | Inhibition of mushroom tyrosinase using L-tyrosine as substrate after 30 mins by spectrophotometric analysis | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis of novel azo-resveratrol, azo-oxyresveratrol and their derivatives as potent tyrosinase inhibitors. |
| AID1371457 | Tmax in mouse at 100 mg/kg, po by HPLC method | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID359554 | Inhibition of induction of ALP activity in mouse MC3T3-E1 cells at 1 uM after 48 hrs in presence of noggin | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1879017 | Inhibition of apoptosis in CCL-4 induced liver fibrosis C57/B6J mouse model at 100 mg/kg/day, ip measured after 72 hrs post last dose | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID475505 | Binding affinity to amyloid beta (1 to 42) oligomers by change in fluorescence at 100 uM after 10 mins | 2009 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17 | A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta. |
| AID1256181 | Decrease in lasR gene expression in Pseudomonas aeruginosa PAO1 at 400 uM by RT-PCR analysis | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | The quorum-sensing inhibiting effects of stilbenoids and their potential structure-activity relationship. |
| AID730557 | Antinociceptive activity in Swiss mouse assessed as inhibition of capsaicin-induced increase of c-Fos expression in brain cortex at 100 mg/kg, po by immunohistochemistry analysis | 2013 | Journal of natural products, Jan-25, Volume: 76, Issue:1 | Evidence for the analgesic activity of resveratrol in acute models of nociception in mice. |
| AID762890 | Effect on p53 expression in H2O2-induced HUVEC pretreated for 1 day followed by compound washout and H2O2-treatment measured after 10 days by immunoblotting analysis | 2013 | Journal of natural products, Jul-26, Volume: 76, Issue:7 | trans-Resveratrol in Gnetum gnemon protects against oxidative-stress-induced endothelial senescence. |
| AID719279 | Inhibition of mushroom tyrosinase using L-tyrosine as substrate at 1 uM after 30 mins by spectrophotometric analysis | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis of novel azo-resveratrol, azo-oxyresveratrol and their derivatives as potent tyrosinase inhibitors. |
| AID1430688 | Half life in human hepatocytes at 5 uM by LC-MS/MS analysis | 2017 | ACS medicinal chemistry letters, May-11, Volume: 8, Issue:5 | Toward Resolving the Resveratrol Conundrum: Synthesis and |
| AID359525 | Effect on matrix metalloprotease 8 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID458143 | Antimicrobial activity against Streptococcus mutans KCTC 3065 at 400 ug/ml after 20 hrs by disk diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | The antimicrobial activity of compounds from the leaf and stem of Vitis amurensis against two oral pathogens. |
| AID1502974 | Reduction in LDL in swine with metabolic syndrome and myocardial ischemia | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Lipid lowering agents of natural origin: An account of some promising chemotypes. |
| AID1238827 | Retention time of the compound in C57BL/6J mouse colon treated with RAH at 200 mg/kg, ig by HPLC-CEAD analysis | 2015 | Journal of medicinal chemistry, Aug-27, Volume: 58, Issue:16 | Novel Resveratrol-Based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer Activity. |
| AID1256177 | Antibacterial activity in Pseudomonas aeruginosa PAO1 at 400 uM measured every 2 hrs for 24 hrs by microplate reader analysis | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | The quorum-sensing inhibiting effects of stilbenoids and their potential structure-activity relationship. |
| AID406774 | DPPH radical scavenging activity at 100 uM | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | Efficient synthesis and neuroprotective effect of substituted 1,3-diphenyl-2-propen-1-ones. |
| AID1467684 | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assay | 2017 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14 | Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor. |
| AID549838 | Activity at AhR expressed in mouse H1L1.1c2 cells co-expressing XRE assessed as increase of benzo[b]fluoranthene-induced luciferase gene expression at 1 uM after 72 hrs | 2011 | Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1 | New hydroxystilbenoid derivatives endowed with neuroprotective activity and devoid of interference with estrogen and aryl hydrocarbon receptor-mediated transcription. |
| AID1298289 | Reduction in dGTP level in human U373-MAGI cells at 50 uM after 6 hrs by LC-MS/MS analysis | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID359297 | Effect on annexin A5 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID359519 | Effect on MAD homolog 6 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1347864 | Inhibition of alpha-MSH-induced TRP-2 expression in human A375 cells at 25 uM after 24 hrs by Western blot method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, synthesis and evaluation of novel dihydrostilbene derivatives as potential anti-melanogenic skin-protecting agents. |
| AID1272522 | Antagonist activity at rat TRPA1 expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced increase of intracellular calcium level | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | TRPA1 channels as targets for resveratrol and related stilbenoids. |
| AID642340 | Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins by spectrophotometry | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets. |
| AID404418 | Spasmolytic activity in guinea pig terminal ilea relative to resveratrol | 2008 | Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11 | Benzanilides with spasmolytic activity: chemistry, pharmacology, and SAR. |
| AID359285 | Inhibition of IGF-induced Akt phosphorylation in human MDA-MB-231 cells by Western blot | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1878995 | Inhibition of TGF-beta1 induced apoptosis in C57/B6J mouse primary hepatocytes assessed as decrease in cleaved-caspase-3 expression at 10 to 50 uM by Western blot analysis | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID1480842 | Inhibition of amyloid beta (1 to 42) (unknown origin) self-aggregation at 20 uM after 48 hrs by thioflavin T fluorescence assay relative to control | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment. |
| AID1607891 | Inhibition of COX2 (unknown origin) at 0.01 mM using arachidonic acid as substrate preincubated for 15 mins followed by arachidonic acid addition measured after 2 mins by ELISA relative to control | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Human disorders associated with inflammation and the evolving role of natural products to overcome. |
| AID1309161 | Binding affinity to Zn2+ using ZnCl2 at 20 uM after 5 mins by spectrophotometry | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Ionophoric polyphenols selectively bind Cu(2+), display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila. |
| AID1225524 | Reduction in thickness of epithelium tissue in prostate tissue in BPH-induced Sprague-Dawley rat model at 1 mg/kg, ip daily for 4 weeks by Hematoxylin and eosin staining based microscopy | 2015 | Journal of natural products, Apr-24, Volume: 78, Issue:4 | Effects of resveratrol on benign prostatic hyperplasia by the regulation of inflammatory and apoptotic proteins. |
| AID610299 | Increase in Lactobacilli count in C57BL/6J mouse distal colon mucosa with DSS-induced colon inflammation at 2.1 mg/kg/day, po for 21 days followed by compound dosing for 8 days co-administered with DSS followed by 2.1 mg/kg/day, po dosing for 6 days in ab | 2010 | Journal of medicinal chemistry, Oct-28, Volume: 53, Issue:20 | Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents. |
| AID1647485 | Noncompetitive inhibition of PTP1B (unknown origin) assessed as decrease in p-nitrophenolate formation using using pNPP as substrate by Lineweaver-Burk plot analysis | 2020 | Journal of natural products, 02-28, Volume: 83, Issue:2 | Stilbenes with Potent Protein Tyrosine Phosphatase-1B Inhibitory Activity from the Roots of |
| AID667234 | Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents. |
| AID359062 | Reversal of increase in pBMP2 expression in mouse MC3T3-E1 cells at 1 uM by luciferase method in presence of PP2 | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID735924 | Activation of N-terminal His6-tagged SIRT1 (156 to 664 amino acid residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using ac-RHKKac-AMC as substrate at 50 uM after 45 mins by fluorimetric analysis relative to control | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate. |
| AID1309183 | Inhibition of preformed self-induced amyloid beta (1 to 40) (unknown origin) fibril aggregation assessed as remaining fibril aggregates at 100 uM after 4 days at pH 6.60 by thioflavin-T fluorescence assay | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Ionophoric polyphenols selectively bind Cu(2+), display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila. |
| AID1607883 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess reagent based assay | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Human disorders associated with inflammation and the evolving role of natural products to overcome. |
| AID332218 | Inhibition of COX2 | 2002 | Journal of natural products, Feb, Volume: 65, Issue:2 | Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity. |
| AID234681 | Free radical scavenging activity of DPPH w.r.t. resveratrol was determined | 2004 | Bioorganic & medicinal chemistry letters, Jan-19, Volume: 14, Issue:2 | Syntheses and radical scavenging activities of resveratrol derivatives. |
| AID455035 | Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay | 2009 | Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18 | E-Combretastatin and E-resveratrol structural modifications: antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes. |
| AID491619 | Inhibition of TNF-alpha-induced NF-kappaB activity expressed in HEK293 cells after 48 hrs by luciferase reporter gene assay | 2010 | Journal of medicinal chemistry, Jul-08, Volume: 53, Issue:13 | Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. |
| AID1826663 | Inhibition of human recombinant MAO-A by fluorescence assay | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades. |
| AID620727 | Antiproliferative activity against human SK-N-SH cells assessed as cell viability after 48 hrs by SRB assay | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | Design and synthesis of resveratrol-based nitrovinylstilbenes as antimitotic agents. |
| AID468347 | Antiadipogenic activity against mouse 3T3L1 cells assessed as inhibition of differentiation after 7 days by oil-red O staining | 2009 | Journal of natural products, Oct, Volume: 72, Issue:10 | Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides. |
| AID1652957 | Inhibition of Sirtuin (unknown origin) | 2019 | European journal of medicinal chemistry, Jan-01, Volume: 161 | An overview of Sirtuins as potential therapeutic target: Structure, function and modulators. |
| AID378683 | Inhibition of PKD | 2006 | Journal of natural products, Jan, Volume: 69, Issue:1 | A common protein fold topology shared by flavonoid biosynthetic enzymes and therapeutic targets. |
| AID471946 | Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay | 2009 | Journal of natural products, Sep, Volume: 72, Issue:9 | Antineoplastic agents. 579. Synthesis and cancer cell growth evaluation of E-stilstatin 3: a resveratrol structural modification. |
| AID359506 | Effect on insulin-like growth factor 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1281400 | Cytotoxicity against human MDA-MB-231 cells after 96 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Non-symmetrical furan-amidines as novel leads for the treatment of cancer and malaria. |
| AID1486518 | Inhibition of acid-induced wild type transthyretin (unknown origin) aggregation expressed in Escherichia coli pre-incubated for 30 mins before acid addition and further incubated for 72 hrs at 37 degC under dark conditions by UV-Vis spectrophotometry | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors. |
| AID667232 | Cytotoxicity against human Lipo cells after 96 hrs by SRB assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents. |
| AID359321 | Effect on procollagen 6 alpha 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID320802 | Inhibition of beta amyloid 25-35 fibril formation | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2 | New polyphenols active on beta-amyloid aggregation. |
| AID359556 | Inhibition of antiapoptotic activity in mouse MC3T3-E1 cells at 1 uM after 48 hrs in presence of BMP2-specific neutralizing antibody | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1371375 | Cytotoxicity against human PANC1 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID359294 | Antiproliferative activity against human MDA-MB-231 cells at 1 uM by flow cytometry | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID359096 | Inhibition of TNF-alpha-induced apoptosis in rat primary osteoblast cells after 24 hrs by flow cytometry | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID638149 | Bactericidal activity against CagA-deficient Helicobacter pylori 328 KM isolated from chronic gastritis patient compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID359058 | Reversal of increase in DNA-binding activity of ERalpha in nuclear extracts of mouse MC3T3-E1 cells by electrophoretic mobility shift assays in presence of short interfering ER alpha-RNA | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID598203 | Inhibition of amyloid beta (25 to 35) fibril formation at 10 uM by UV-visible spectrometry analysis | 2011 | Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10 | Protective effect of ε-viniferin on β-amyloid peptide aggregation investigated by electrospray ionization mass spectrometry. |
| AID1450153 | Growth inhibition of BAEC after 2 days by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11 | One drug for two targets: Biological evaluation of antiretroviral agents endowed with antiproliferative activity. |
| AID1203664 | Induction of apoptosis in human Bel7402 cells assessed as live cells at 50 uM after 48 hrs by flow cytometry (Rvb = 98.65%) | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Design, synthesis, and biological evaluation of benzoselenazole-stilbene hybrids as multi-target-directed anti-cancer agents. |
| AID1632199 | Cytotoxicity against human T24 cells after 48 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18 | Synthesis and anticancer activity of a hydroxytolan series. |
| AID1872746 | Inhibition of human recombinant MAO-A incubated for 15 mins by Amplex red MAO assay | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy. |
| AID1406257 | Antioxidant activity assessed as DPPH free radical scavenging activity after 90 mins dark incubation | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities. |
| AID359331 | Effect on procollagen 3 alpha 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID402931 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 12 after 24 hrs | 2004 | Journal of natural products, Jun, Volume: 67, Issue:6 | New stilbene derivatives from Calligonum leucocladum. |
| AID1420927 | Antioxidant activity assessed as trolox equivalent of AAPH-induced radical scavenging activity preincubated for 30 mins followed by APPH challenge measured every 1.14 mins for 120 mins by ORAC-FL assay | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Antibacterial and antioxidant activities for natural and synthetic dual-active compounds. |
| AID1309184 | Inhibition of preformed self-induced amyloid beta (1 to 40) (unknown origin) fibril aggregation assessed as remaining fibril aggregates at 100 uM after 12 days at pH 6.60 by thioflavin-T fluorescence assay | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Ionophoric polyphenols selectively bind Cu(2+), display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila. |
| AID331081 | Effect on body weight in diabetic Lep ob/ob mouse model at 1000 mg/kg, po | 2007 | Nature, Nov-29, Volume: 450, Issue:7170 | Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. |
| AID359283 | Reversal of inhibition in anchorage-independent colony formation of human MDA-MB-231 cells transfected with FOXO3a-specific small interfering RNA by soft agar colony forming assay | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID460549 | Antiaging effect in Saccharomyces cerevisiae K6001 assessed as extension of replicative life span at 10 uM after 2 days | 2010 | Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3 | Ganodermasides A and B, two novel anti-aging ergosterols from spores of a medicinal mushroom Ganoderma lucidum on yeast via UTH1 gene. |
| AID1371389 | Cytotoxicity against human SK-MEL-2 cells assessed as cell viability at 16 uM after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1430686 | Half life in Wistar rat at 20 mg/kg, po by HPLC-MS analysis | 2017 | ACS medicinal chemistry letters, May-11, Volume: 8, Issue:5 | Toward Resolving the Resveratrol Conundrum: Synthesis and |
| AID402929 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 5 after 24 hrs | 2004 | Journal of natural products, Jun, Volume: 67, Issue:6 | New stilbene derivatives from Calligonum leucocladum. |
| AID1183073 | Antifungal activity against Candida albicans SC5314 ATCC MYA-2876 assessed as growth inhibition at 300 ug/ml after 48 hrs by broth microdilution method | 2014 | Journal of natural products, Jul-25, Volume: 77, Issue:7 | Antifungal activity of resveratrol derivatives against Candida species. |
| AID1374190 | Estrogenic activity at ERalpha/ERbeta (unknown origin) expressed in human HepG2 cells co-expressing ERE-dependent promoter assessed as increase in ER-mediated transcriptional activation at 10 uM incubated for 24 hrs by luciferase reporter gene assay relat | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Estrogenic activity of constituents from the rhizomes of Rheum undulatum Linné. |
| AID726367 | Antioxidant activity assessed as DPPH radical scavenging activity at 12.5 uM after 30 mins by spectrophotometry | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Antioxidant activities of thiosemicarbazones from substituted benzaldehydes and N-(tetra-O-acetyl-β-D-galactopyranosyl)thiosemicarbazide. |
| AID359110 | Increase in serum BMP2 levels in ovariectomized Wistar rat at 10 mg/kg, po after 10 weeks by ELISA relative to sham operated control | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1628090 | Activation of SIRT1 in human HaCaT cells assessed as H4K16 deacetylation at 1 uM after 1 hr by Western blotting method | 2016 | Journal of medicinal chemistry, Feb-25, Volume: 59, Issue:4 | 1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells. |
| AID1632195 | Cytotoxicity against human T24 cells after 24 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18 | Synthesis and anticancer activity of a hydroxytolan series. |
| AID359528 | Effect on ubiquitin-conjugating enzyme E2D 3 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID725946 | Inhibition of recombinant firefly luciferase at 1 nM after 20 mins by luminescence assay | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Discovery of 5-benzyl-3-phenyl-4,5-dihydroisoxazoles and 5-benzyl-3-phenyl-1,4,2-dioxazoles as potent firefly luciferase inhibitors. |
| AID1499670 | Antioxidant activity assessed as DPPH radical scavenging activity measured at 30 to 60 mins by UV-Visible spectrophotometric method | 2017 | European journal of medicinal chemistry, Sep-29, Volume: 138 | Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity. |
| AID1210979 | Drug metabolism in mouse lung S9 fractions assessed as trans-resveratrol-3-sulfate formation preincubated for 3 mins followed by PAPS addition measured after 60 mins by Eadie-Hofstee plot analysis | 2013 | Drug metabolism and disposition: the biological fate of chemicals, May, Volume: 41, Issue:5 | Pulmonary metabolism of resveratrol: in vitro and in vivo evidence. |
| AID1632231 | Solubility of the compound in water | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18 | Synthesis and anticancer activity of a hydroxytolan series. |
| AID458152 | Antimicrobial activity against Streptococcus mutans KCTC 3065 assessed as total bacterial adherence inhibition | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | The antimicrobial activity of compounds from the leaf and stem of Vitis amurensis against two oral pathogens. |
| AID359123 | Reversal of induction in BMP2 expression in mouse MC3T3-E1 cells at 1 uM by Western blot in presence of PP2 | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1083159 | Antifungal activity against Diplodia mutila BRA08 assessed as growth inhibition measured after 1 to 10 days | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID699922 | Cytotoxicity against human U373-MAGI cells expressing CXCR4 | 2012 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 22, Issue:21 | Anti-HIV-1 activity of resveratrol derivatives and synergistic inhibition of HIV-1 by the combination of resveratrol and decitabine. |
| AID402928 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 1 after 24 hrs | 2004 | Journal of natural products, Jun, Volume: 67, Issue:6 | New stilbene derivatives from Calligonum leucocladum. |
| AID641062 | Antihyperglycemic activity in ddY mouse assessed as inhibition of sucrose-induced increase in plasma glucose level at 100 mg/kg, po administered 30 mins before sucrose challenge measured after 1 hr (Rvb = 221.4 +/- 9.1 mg/dl) | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Antidiabetogenic oligostilbenoids and 3-ethyl-4-phenyl-3,4-dihydroisocoumarins from the bark of Shorea roxburghii. |
| AID274761 | Inhibition of LPS and TNF-alpha-activated NO production in murine RAW 264.7 cells | 2007 | Journal of natural products, Jan, Volume: 70, Issue:1 | Bioactive bibenzyl derivatives and fluorenones from Dendrobium nobile. |
| AID1337907 | Chemical stability of the compound in phosphate buffer at pH 7.4 at 20 uM measured every 5 mins for 25 mins by UV-visible absorption spectra analysis | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Development of resveratrol-curcumin hybrids as potential therapeutic agents for inflammatory lung diseases. |
| AID359191 | Blockade of human Glut3 expressed in CHO cells assessed as inhibition of 2-[1,2-3H(N)]deoxy-D-glucose uptake by scintillation spectrometry | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3 | Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells. |
| AID1888432 | Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by DTNB-reagent based Ellman's method | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Design, synthesis, and biological evaluation of novel (4-(1,2,4-oxadiazol-5-yl)phenyl)-2-aminoacetamide derivatives as multifunctional agents for the treatment of Alzheimer's disease. |
| AID293297 | Antioxidant activity assessed as DPPH radical scavenging activity after 20 min | 2007 | Bioorganic & medicinal chemistry, Feb-15, Volume: 15, Issue:4 | Improved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems. |
| AID1362653 | Disaggregation of Cu2+ induced amyloid beta (1 to 40) preformed fibrils assessed as aggregation level at 100 uM after 12 days by UV-visible turbidity method (Rvb = 120.73 +/- 1.86%) | |||
| AID404513 | Binding affinity to human serum albumin by fluorescence quenching measurement | 2008 | Bioorganic & medicinal chemistry, Jun-15, Volume: 16, Issue:12 | Design, synthesis and spectroscopic studies of resveratrol aliphatic acid ligands of human serum albumin. |
| AID1298410 | Potentiation of 5-Aza-dC-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as increase in frequency of C to G transversion at 50 uM incubated for 4 hrs preinfection followed by 5-Aza-C addition for | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1333794 | Antibacterial activity Escherichia coli KCTC 1924 at 64 ug/ml after 24 hrs by serial dilution method | 2017 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1 | Synthesis and bioactivity evaluation of 2,3-diaryl acrylonitrile derivatives as potential anticancer agents. |
| AID1168373 | Hepatoprotective activity against isoniazid-rifampicin induced liver injury in BALB/c mouse assessed as reduction in PGC-1alpha mRNA level at 100 mg/kg, po bid for 3 days starting 30 mins prior isoniazid-rifampicin administration measured 24 hrs post-last | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. |
| AID458149 | Antimicrobial activity against Streptococcus sanguinis NCTC 9811 at 600 ug/ml after 20 hrs by disk diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | The antimicrobial activity of compounds from the leaf and stem of Vitis amurensis against two oral pathogens. |
| AID416360 | Inhibition of Fe(2+)/ascorbate-induced lipid peroxidation in human erythrocyte ghosts assessed as inhibition of malondialdehyde formation per mg of protein at 1 uM after 30 mins | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6 | 4,4'-Dihydroxy-trans-stilbene, a resveratrol analogue, exhibited enhanced antioxidant activity and cytotoxicity. |
| AID430028 | Antiproliferative activity against human HT144 cells assessed as cell proliferation at 20 uM after 5 days by acid phosphatase assay | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13 | Synthesis, structural characterisation and biological evaluation of fluorinated analogues of resveratrol. |
| AID458142 | Antimicrobial activity against Streptococcus mutans KCTC 3065 at 200 ug/ml after 20 hrs by disk diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | The antimicrobial activity of compounds from the leaf and stem of Vitis amurensis against two oral pathogens. |
| AID724378 | Antioxidant activity in planer lipid bilayer membrane assessed as reduction in 50 uM DPPH-induced charge transfer resistance at 100 uM by admittance spectroscopic analysis | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Dose-dependent interaction of trans-resveratrol with biomembranes: effects on antioxidant property. |
| AID1519076 | Cytotoxicity against C57BL/6 mouse B16F10 cells assessed as increase in cell shrinking at 50 uM incubated for 48 hrs by microscopic method | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | From bench to counter: Discovery and validation of a peony extract as tyrosinase inhibiting cosmeceutical. |
| AID1878983 | Inhibition of TGF-beta1 induced apoptosis in C57/B6J mouse primary hepatocytes assessed as early apoptotic cells at 10 uM by Annexin-V-FITC-H and PI staining based flow cytometry analysis (Rvb = 18.71 %) | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID620726 | Antiproliferative activity against human MCF7 cells assessed as cell viability after 48 hrs by SRB assay | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | Design and synthesis of resveratrol-based nitrovinylstilbenes as antimitotic agents. |
| AID667229 | Cytotoxicity against human A549 cells after 96 hrs by SRB assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents. |
| AID1309193 | Inhibition of preformed Cu2+-induced amyloid beta (1 to 40) fibril aggregation at 100 uM after 4 to 12 days by turbidity assay relative to control | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Ionophoric polyphenols selectively bind Cu(2+), display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila. |
| AID271287 | Inhibition of ovine COX2 | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17 | Selective COX-2 inhibitors. Part 1: synthesis and biological evaluation of phenylazobenzenesulfonamides. |
| AID639318 | Antibacterial activity against CagA-expressing Helicobacter pylori CCUG17874 isolated from chronic gastritis patient after 24 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID491522 | Inhibition of LPS-induced iNOS expression in mouse RAW264.7 cells at 34 uM treated 15 mins before LPS challenge measured after 18 hrs by Western blotting | 2010 | Journal of medicinal chemistry, Jul-08, Volume: 53, Issue:13 | Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. |
| AID762889 | Effect on SIRT1 expression in H2O2-induced HUVEC pretreated for 1 day followed by compound washout and H2O2-treatment measured after 10 days by immunoblotting analysis | 2013 | Journal of natural products, Jul-26, Volume: 76, Issue:7 | trans-Resveratrol in Gnetum gnemon protects against oxidative-stress-induced endothelial senescence. |
| AID200787 | In vitro growth inhibition of central nervous system SF-268 cell line. | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID692949 | Inhibition of Wnt/beta-casein in human LS174T cells assessed as reduction in survivin mRNA level at 100 uM after 36 hrs by RT-PCR analysis | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID1335883 | Growth inhibition of human HT-29 cells after 48 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Discovery of oral-available resveratrol-caffeic acid based hybrids inhibiting acetylated and phosphorylated STAT3 protein. |
| AID333444 | Binding affinity to COX1 in sheep seminal vesicle | 2004 | Journal of natural products, Nov, Volume: 67, Issue:11 | Mechanism-based inactivation of COX-1 by red wine m-hydroquinones: a structure-activity relationship study. |
| AID404512 | Solubility in phosphate buffer assessed per 100 g at pH 7 | 2008 | Bioorganic & medicinal chemistry, Jun-15, Volume: 16, Issue:12 | Design, synthesis and spectroscopic studies of resveratrol aliphatic acid ligands of human serum albumin. |
| AID1225533 | Reduction in prostate cell proliferation and gland development in BPH-induced Sprague-Dawley rat model at 1 mg/kg, ip daily for 4 weeks by Hematoxylin and eosin staining based microscopy | 2015 | Journal of natural products, Apr-24, Volume: 78, Issue:4 | Effects of resveratrol on benign prostatic hyperplasia by the regulation of inflammatory and apoptotic proteins. |
| AID1700047 | Inhibition of human erythrocytes AChE by Ellman's method | 2020 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 30, Issue:24 | Novel deoxyvasicinone and tetrahydro-beta-carboline hybrids as inhibitors of acetylcholinesterase and amyloid beta aggregation. |
| AID432135 | Inhibition of phagocytosis of FITC-conjugated Escherichia coli K12 in mouse RAW264.7 cells using trypan blue staining after 80 mins by flow cytometry | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID650851 | Antioxidant activity assessed as DPPH free radical scavenging activity | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7 | Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol. |
| AID1632204 | Cytotoxicity against human MDAH 2774 cells after 72 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18 | Synthesis and anticancer activity of a hydroxytolan series. |
| AID491616 | Inhibition of human recombinant COX2 assessed as PGE2 production at 34 uM after 10 mins by ELISA relative to control | 2010 | Journal of medicinal chemistry, Jul-08, Volume: 53, Issue:13 | Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. |
| AID537627 | Inhibition of Schistosoma mansoni recombinant NAD+ glycohydrolase expressed in Pichia pastoris by continuous fluorometric method | 2010 | Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22 | Identification by high-throughput screening of inhibitors of Schistosoma mansoni NAD(+) catabolizing enzyme. |
| AID1210973 | Clearance in C57BL/6 mouse at 15 mg/kg, iv | 2013 | Drug metabolism and disposition: the biological fate of chemicals, May, Volume: 41, Issue:5 | Pulmonary metabolism of resveratrol: in vitro and in vivo evidence. |
| AID1331319 | Antioxidant activity assessed as ABTS free radical scavenging activity at 10 uM | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2 | Synthesis and application of β-carbolines as novel multi-functional anti-Alzheimer's disease agents. |
| AID1298432 | Antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as Env mutation at 50 uM incubated for 4 hrs prior to infection measured at 72 hrs post infection by illumina sequencing method (Rvb = 21.4%) | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID239550 | Binding affinity for aryl hydrocarbon receptor (AhR) of rabbit liver cytosol incubated with 0.2 nM [3H]-TCDD; Antagonist | 2005 | Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1 | Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. |
| AID315991 | Inhibition of COX1 in human whole blood assessed as effect on A-23187-stimulated TxB2 production | 2008 | Bioorganic & medicinal chemistry, Mar-01, Volume: 16, Issue:5 | Selective COX-2 inhibitors. Part 2: synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides. |
| AID1467699 | Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced current response by whole cell patch clamp method | 2017 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14 | Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor. |
| AID1261078 | Cytotoxicity against human MCF7 cells assessed inhibition of cell proliferation after 2 days by MTT assay | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Inhibitory effect of cytotoxic stilbenes related to resveratrol on the expression of the VEGF, hTERT and c-Myc genes. |
| AID359192 | Blockade of human Glut3 expressed in CHO cells assessed as inhibition of [14C]dehydroascorbic acid uptake by scintillation spectrometry | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3 | Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells. |
| AID1298298 | Reduction in dCTP level in human U373-MAGI cells at 50 uM after 6 hrs by LC-MS/MS analysis | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1609877 | Induction of apoptosis in human HuH7 cells overexpressing SGK1 at 100 uM incubated for 48 hrs by annexin V and 7-AAD staining based assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Review about the multi-target profile of resveratrol and its implication in the SGK1 inhibition. |
| AID713093 | Inhibition of mushroom tyrosinase-mediated L-DOPA oxidation assessed as recovery of enzymatic activity at 100 uM preincubated for 30 mins by HPLC analysis in the presence of 200 uM of L-cysteine | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID716922 | Cytotoxicity against mouse B16F10 cells assessed as suppression of cell viability at 200 uM after 72 hrs | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID1278616 | Antioxidant activity in human HepG2 cells assessed as reduction of H2O2-induced ROS level at 10 uM pretreated for 20 hrs followed by H2O2 stimulation for 30 mins by DCF-DA-based fluorescence analysis relative to control | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog. |
| AID359510 | Effect on integrin alpha 3 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID549843 | Antagonist activity at human ERbeta receptor expressed in human HEK293 cells co-expressing ERE assessed as inhibition of estradiol-induced of luciferase gene expression at 1 uM after 18 hrs relative to ICI182780 | 2011 | Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1 | New hydroxystilbenoid derivatives endowed with neuroprotective activity and devoid of interference with estrogen and aryl hydrocarbon receptor-mediated transcription. |
| AID1609875 | Antiproliferative activity against human HuH7 cells overexpressing EGFP assessed as reduction in cell viability at 100 uM incubated for 48 hrs by trypan blue dye based assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Review about the multi-target profile of resveratrol and its implication in the SGK1 inhibition. |
| AID359068 | Induction of ER association with BMP2 promoter in mouse MC3T3-E1 cells at 1 uM by ChiP assay | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID598207 | Inhibition of amyloid beta (1 to 42) fibril formation at 10 uM by UV-visible spectrometry analysis | 2011 | Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10 | Protective effect of ε-viniferin on β-amyloid peptide aggregation investigated by electrospray ionization mass spectrometry. |
| AID1420929 | Antioxidant activity assessed as reduction of Fe3+-TPTZ to Fe2+-TPTZ by measuring trolox equivalence of antioxidant capacity by FRAP assay | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Antibacterial and antioxidant activities for natural and synthetic dual-active compounds. |
| AID1371391 | Cytotoxicity against human LN229 cells assessed as cell viability at 16 uM after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID396457 | Antioxidant activity assessed as free radical scavenging activity at 10 uM | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Synthesis and in vitro biological activity of retinyl polyhydroxybenzoates, novel hybrid retinoid derivatives. |
| AID730561 | Antinociceptive activity in Swiss mouse assessed as inhibition of glutamate-induced biting behavior at 300 ug/site, administered intrathecally | 2013 | Journal of natural products, Jan-25, Volume: 76, Issue:1 | Evidence for the analgesic activity of resveratrol in acute models of nociception in mice. |
| AID1060586 | Inhibition of Cu2+-induced amyloid beta (1 to 42) (unknown origin) aggregation at 50 uM after 24 hrs by thioflavin-T based fluorometric assay | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Design, synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer's disease. |
| AID1168366 | Hepatoprotective activity against isoniazid-rifampicin induced liver injury in BALB/c mouse assessed as change in SIRT2 mRNA level at 100 mg/kg, po bid for 3 days starting 30 mins prior isoniazid-rifampicin administration measured 24 hrs post-last dose of | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. |
| AID1256175 | Inhibition of Quorum sensing system in Pseudomonas aeruginosa PAO1 assessed as inhibition of pyocyanin production at sub-MIC concentration after 16 to 18 hrs by spectrophotometric assay | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | The quorum-sensing inhibiting effects of stilbenoids and their potential structure-activity relationship. |
| AID1533710 | Inhibition of human CYP1B1 by EROD assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Phytoestrogens and their synthetic analogues as substrate mimic inhibitors of CYP1B1. |
| AID402932 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus COL after 24 hrs | 2004 | Journal of natural products, Jun, Volume: 67, Issue:6 | New stilbene derivatives from Calligonum leucocladum. |
| AID719281 | Inhibition of mushroom tyrosinase using L-tyrosine as substrate at 30 uM after 30 mins by spectrophotometric analysis | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis of novel azo-resveratrol, azo-oxyresveratrol and their derivatives as potent tyrosinase inhibitors. |
| AID1081911 | Antifungal activity against Botryotinia fuckeliana assessed as growth inhibition after 72 hr by NCCLS M27-A broth microdilution method | 2011 | Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5 | Biological activity of peanut (Arachis hypogaea) phytoalexins and selected natural and synthetic Stilbenoids. |
| AID1298327 | Reduction in dCTP level in human U373-MAGI cells at 200 uM preincubated for 2 hrs followed by 5-aza-C addition measured after 4 hrs by LC-MS/MS analysis relative to 5-aza-C | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID359521 | Effect on MAD homolog 9 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID401040 | Antioxidant activity against cupric ion-induced lipid peroxidation in human LDL by TBA assay | 1998 | Journal of natural products, May, Volume: 61, Issue:5 | Isolation, identification, and antioxidant activity of three stilbene glucosides newly extracted from vitis vinifera cell cultures |
| AID1333784 | Cytotoxicity against human Bel7402 cells assessed as cell growth inhibition after 48 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1 | Synthesis and bioactivity evaluation of 2,3-diaryl acrylonitrile derivatives as potential anticancer agents. |
| AID1298277 | Potentiation of 5-Aza-C-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as reduction in viral infectivity at 25 to 100 uM preincubated for 2 hrs followed by 5-Aza-C addition for 2 hrs and subsequ | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1333792 | Antibacterial activity Staphylococcus aureus RN4220 at 64 ug/ml after 24 hrs by serial dilution method | 2017 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1 | Synthesis and bioactivity evaluation of 2,3-diaryl acrylonitrile derivatives as potential anticancer agents. |
| AID692952 | Inhibition of Wnt/beta-casein in human LS174T cells assessed as reduction in cyclin B1 protein level at 100 uM by Western blotting | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID356481 | ABTS radical scavenging activity assessed as trolox equivalent antioxidant capacity after 10 mins | 2003 | Journal of natural products, Sep, Volume: 66, Issue:9 | Resveratrol and two monomethylated stilbenes from Israeli Rumex bucephalophorus and their antioxidant potential. |
| AID1772546 | Aqueous solubility of the compound | 2021 | European journal of medicinal chemistry, Nov-05, Volume: 223 | Silyl resveratrol derivatives as potential therapeutic agents for neurodegenerative and neurological diseases. |
| AID716918 | Inhibition of mushroom tyrosinase-mediated L-tyrosine oxidation after 60 mins by HPLC analysis | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID432143 | Inhibition of phagocytosis of FITC-conjugated Staphylococcus aureus 209P in human THP1 cells assessed as reduction in ratio of number of bacterial cells to phagocytes using trypan blue staining by flow cytometry | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID1676776 | Induction of membrane perturbation in DC22:1PC LUV bilayer assessed as change in deltaG for gramicidin mixture monomer to to dimer by fluorescence quenching assay (Rvb = 0 kcal/mol) | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20 | Assessing the Perturbing Effects of Drugs on Lipid Bilayers Using Gramicidin Channel-Based |
| AID1611507 | Photoprotection activity against UV radiation | 2019 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 29, Issue:24 | Synthesis and evaluation of 1,3,5-triazine derivatives as sunscreens useful to prevent skin cancer. |
| AID1256163 | Inhibition of Quorum sensing system in Chromobacterium violaceum CV026 assessed as inhibition of violacein synthesis at 25 to 150 uM after 18 hrs by spectrophotometric assay | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | The quorum-sensing inhibiting effects of stilbenoids and their potential structure-activity relationship. |
| AID359082 | Increase in osteocalcin levels in mouse MC3T3-E1 cells at 1 uM after 72 hrs by ELISA | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID359335 | Effect on decorin gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID359303 | Effect on bone morphogenetic protein 3 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1362753 | Immunomodulatory activity in LPS-stimulated mouse RAW264.7 cells assessed as decrease in CD80 expression at 50 uM incubated with LPS for 1 hr followed by compound addition measured after 24 hrs by flow cytometry | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues. |
| AID1879011 | Inhibition of TGF-beta1 induced apoptosis in C57/B6J mouse primary hepatocytes assessed as dead cells in presence of miR-190a-5p mimic by Annexin-V-FITC-H and PI staining based flow cytometry analysis (Rvb = 3.68 %) | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID416365 | Cytotoxicity against human HL60 cells at 20 uM after 48 hrs by MTT assay | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6 | 4,4'-Dihydroxy-trans-stilbene, a resveratrol analogue, exhibited enhanced antioxidant activity and cytotoxicity. |
| AID1083158 | Antifungal activity against Diplodia seriata PLU03 assessed as growth inhibition measured after 1 to 10 days | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID637962 | Antibacterial activity against CagA-expressing Helicobacter pylori MD6 isolated from chronic gastritis patient after 48 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID692954 | Inhibition of Wnt/beta-casein in human LS174T cells assessed as reduction in Cyclin D1 protein level at 100 uM by Western blotting | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID1882448 | Inhibition of human HDAC2 at 100 uM relative to control | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4 | Chasing a Breath of Fresh Air in Cystic Fibrosis (CF): Therapeutic Potential of Selective HDAC6 Inhibitors to Tackle Multiple Pathways in CF Pathophysiology. |
| AID455033 | Cytotoxicity against human SF295 cells after 48 hrs by sulforhodamine B assay | 2009 | Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18 | E-Combretastatin and E-resveratrol structural modifications: antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes. |
| AID1168368 | Hepatoprotective activity against isoniazid-rifampicin induced liver injury in BALB/c mouse assessed as change in SIRT4 mRNA level at 100 mg/kg, po bid for 3 days starting 30 mins prior isoniazid-rifampicin administration measured 24 hrs post-last dose of | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. |
| AID359512 | Effect on integrin alpha V gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID94870 | In vitro growth inhibition of KM20L2 cell line. | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID1371463 | Displacement of [3H]resveratrol from Sprague-Dawley rat brain plasma membranes after 1 hr by beta counting method | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1430693 | Drug metabolism in human hepatocytes assessed as resveratrol-sulfate formation at 5 uM by LC-MS/MS analysis | 2017 | ACS medicinal chemistry letters, May-11, Volume: 8, Issue:5 | Toward Resolving the Resveratrol Conundrum: Synthesis and |
| AID1450144 | Down regulation of c-Myc expression in human HT-29 cells assessed as c-Myc expression level at 1 uM after 48 hrs by RT-qPCR analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11 | One drug for two targets: Biological evaluation of antiretroviral agents endowed with antiproliferative activity. |
| AID1374189 | Estrogenic activity at ERalpha/ERbeta (unknown origin) expressed in human HepG2 cells co-expressing ERE-dependent promoter assessed as increase in ER-mediated transcriptional activation at 1 uM incubated for 24 hrs by luciferase reporter gene assay relati | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Estrogenic activity of constituents from the rhizomes of Rheum undulatum Linné. |
| AID637950 | Antibacterial activity against CagA-expressing Helicobacter pylori 1C1 isolated from gastric carcinoma patient after 24 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1298353 | Antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as increase in frequency of T to G transversion at 50 uM incubated for 4 hrs prior to infection measured at 72 hrs post infection by illumina sequencing me | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1326320 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus after 18 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24 | Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ. |
| AID1767564 | Antioxidant activity assessed as DPPH radical scavenging activity at 50 uM incubated for 1 hrs under light restrictive condition by UV-microplate reader assay relative to control | 2021 | European journal of medicinal chemistry, Oct-15, Volume: 222 | Synthesis, biological evaluation and molecular modeling of benzofuran piperidine derivatives as Aβ antiaggregant. |
| AID638152 | Bactericidal activity against CagA-expressing Helicobacter pylori CCUG17874 isolated from chronic gastritis patient compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID259475 | Cytotoxicity against basophilic leukemia RBL 2H3 cell line by MTT assay at 100 uM | 2006 | Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2 | Rapid synthesis of triazole-modified resveratrol analogues via click chemistry. |
| AID639326 | Antibacterial activity against CagA-expressing Helicobacter pylori G20 isolated from chronic gastritis patient after 24 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1225518 | Reduction in prostate weight in BPH-induced Sprague-Dawley rat model at 1 mg/kg, ip daily for 4 weeks in presence testosterone propionate of 10 mg/kg, intramuscular injection for 4 weeks | 2015 | Journal of natural products, Apr-24, Volume: 78, Issue:4 | Effects of resveratrol on benign prostatic hyperplasia by the regulation of inflammatory and apoptotic proteins. |
| AID1705581 | Cytoprotective activity against H2O2-induced cell death in human PC-12 cells assessed as cell viability at 30 to 100 uM incubated for 0.5 hrs followed by H2O2 stimulation and measured after 2 hrs by MTT assay | 2020 | European journal of medicinal chemistry, Dec-01, Volume: 207 | Preparation, characterization, antioxidant evaluation of new curcumin derivatives and effects of forming HSA-bound nanoparticles on the stability and activity. |
| AID434723 | Antioxidant activity assessed as DPPH radical scavenging activity at 10 uM | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Synthesis of novel trans-stilbene derivatives and evaluation of their potent antioxidant and neuroprotective effects. |
| AID273486 | Inhibition of TNF-alpha-induced NF-kappaB activation in HEK293T cells | 2006 | Journal of medicinal chemistry, Nov-30, Volume: 49, Issue:24 | Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB. |
| AID1261086 | Inhibition of VEGF protein secretion in human MCF7 cells at 10 ug/mL after 72 hrs by ELISA relative to control | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Inhibitory effect of cytotoxic stilbenes related to resveratrol on the expression of the VEGF, hTERT and c-Myc genes. |
| AID416675 | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Synthesis and biological evaluation of cytotoxic properties of stilbene-based resveratrol analogs. |
| AID1298344 | Increase in 5-aza-dCTP/dCTP ratio in human U373-MAGI cells at 200 uM preincubated for 2 hrs followed by 5-aza-dC addition measured after 4 hrs by LC-MS/MS analysis relative to 5-aza-dC | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1452983 | Inhibition of recombinant human CYP1B1 expressed in supersomes coexpressing NADPH-CYP reductase using 7-ethoxyresorufin as substrate after 15 mins in presence of NADP+ by Lineweaver-Burk plot analysis | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Inhibitors of cytochrome P450 (CYP) 1B1. |
| AID1470910 | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate measured at 12 secs interval for 10 mins by Ellman's method | 2017 | European journal of medicinal chemistry, May-26, Volume: 132 | Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease. |
| AID359334 | Effect on cathepsin K gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID359091 | Increase in bone mineral density in ovariectomized Wistar rat dosed orally after 10 weeks | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID721441 | Antitumor activity against human HepG2 cells assessed as growth inhibition measured after 48 hrs by MTT assay | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Bioactive barrigenol type triterpenoids from the leaves of Xanthoceras sorbifolia Bunge. |
| AID1261082 | Inhibition of VEGF protein secretion in human HT-29 cells at 10 ug/mL after 72 hrs by ELISA relative to control | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Inhibitory effect of cytotoxic stilbenes related to resveratrol on the expression of the VEGF, hTERT and c-Myc genes. |
| AID359120 | Reversal of induction of BMP2 expression in mouse MC3T3-E1 cells at 1 uM by Western blot in presence of short interfering ERalpha-RNA | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1237135 | Anti-inflammatory activity in C57BL/6 mouse model of LPS-induced acute lung injury assessed as reduction in serum TNFalpha level at 20 mg/kg for 1 week dosed before LPS instillation for 6 hrs | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15 | Design, synthesis and biological evaluation of paralleled Aza resveratrol-chalcone compounds as potential anti-inflammatory agents for the treatment of acute lung injury. |
| AID1676779 | Induction of membrane perturbation in DC22:1PC LUV bilayer assessed as fluorescence quench rate by measuring increase in R(drug)/R(control) ratio by fluorescence quenching assay | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20 | Assessing the Perturbing Effects of Drugs on Lipid Bilayers Using Gramicidin Channel-Based |
| AID1450149 | Growth inhibition of human HT-29 cells after 2 days by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11 | One drug for two targets: Biological evaluation of antiretroviral agents endowed with antiproliferative activity. |
| AID642329 | Induction of QR1 activity in mouse Hepa-1c1c7 cells using MTT as substrate by spectrophotometry | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets. |
| AID1309182 | Inhibition of preformed Cu2+-induced amyloid beta (1 to 40) fibril aggregation assessed as remaining fibril aggregates at 100 uM after 12 days at pH 6.60 by thioflavin-T fluorescence assay | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Ionophoric polyphenols selectively bind Cu(2+), display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila. |
| AID628766 | Antiproliferative activity against human A549 cells after 72 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21 | Synthesis and biological evaluation of hydroxylated 3-phenylcoumarins as antioxidants and antiproliferative agents. |
| AID713107 | Inhibition of mushroom tyrosinase-mediated oxygen consumption using L-tyrosine substrate after 60 mins | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID738181 | Inhibition of Notch signaling pathway in human HeLa cells assessed as inhibition of PMA induced luciferase treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID1770515 | Cytotoxicity against human MCF7 cells assessed as reduction in cell metabolic activity incubated for 72 hrs by MTT assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis, structure-activity relationships and molecular docking studies of phenyldiazenyl sulfonamides as aromatase inhibitors. |
| AID359311 | Effect on bone morphogenetic protein receptor 2 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID501903 | Inhibition of human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration method | 2010 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17 | Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. |
| AID1372030 | Antioxidant activity assessed as relative scavenging rate constant for photolysis-induced singlet oxygen scavenging activity by measuring Kaox/Kst ratio using 4-HO-TEMP spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID641146 | Inhibition of alpha-glucosidase activity of maltase in rat small intestinal brush border membrane fraction using maltose as substrate after 30 mins | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Antidiabetogenic oligostilbenoids and 3-ethyl-4-phenyl-3,4-dihydroisocoumarins from the bark of Shorea roxburghii. |
| AID359183 | Inhibition of [14C]dehydroascorbic acid uptake in human HL60 cells by scintillation spectrometry in presence of buffer containing NaCl and Na2HPO4 | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3 | Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells. |
| AID1054172 | Antiviral activity against HIV1 infected in human U373-MAGI cells assessed as induction of mutations at 50 uM (Rvb = 18%) | 2013 | Bioorganic & medicinal chemistry, Nov-15, Volume: 21, Issue:22 | 5,6-Dihydro-5-aza-2'-deoxycytidine potentiates the anti-HIV-1 activity of ribonucleotide reductase inhibitors. |
| AID1178161 | In vitro photoprotection of the compound assessed as sun protection factor by Optometric 290S analyzer | 2014 | Bioorganic & medicinal chemistry, May-01, Volume: 22, Issue:9 | Synthesis, antioxidant and photoprotection activities of hybrid derivatives useful to prevent skin cancer. |
| AID1083170 | Antifungal activity against Diplodia seriata assessed as growth inhibition at 500 uM measured after 1 to 10 days relative to control | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID359121 | Reversal of induction in nuclear translocation of ERalpha in mouse MC3T3-E1 cells at 1 uM in presence of PP2 | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1632194 | Cytotoxicity against human DU145 cells after 24 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18 | Synthesis and anticancer activity of a hydroxytolan series. |
| AID759450 | Induction of disaggregation of self-mediated amyloid beta (1 to 42) fibril (unknown origin) at 25 uM after 24 hrs by thioflavin T fluorescence assay relative to control | 2013 | Journal of medicinal chemistry, Jul-25, Volume: 56, Issue:14 | Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease. |
| AID432154 | Inhibition of heat killed Staphylococcus aureus 209P-induced nuclear translocation of p65 element of NF-kappaB in HEK293 cells expressing TLR2 at 100 uM pretreated for 1 hr before 6 hrs heat killed bacterial stimulation by immunostaining method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID406772 | DPPH radical scavenging activity at 10 uM | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | Efficient synthesis and neuroprotective effect of substituted 1,3-diphenyl-2-propen-1-ones. |
| AID1246398 | Antagonist activity at ERbeta (248 to 510 amino acid residues) (unknown origin) assessed as inhibition of E2 induced interaction with SRC1 after 24 hrs by yeast-two-hybrid assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Synthesis, estrogenic activity, and anti-osteoporosis effects in ovariectomized rats of resveratrol oligomer derivatives. |
| AID377037 | Ex vivo inhibition of leukotriene formation in calcium ionophore activated human neutrophilic granulocyte at 50 uM by ELISA | 2005 | Journal of natural products, Jan, Volume: 68, Issue:1 | Inhibition of leukotriene biosynthesis by stilbenoids from Stemona species. |
| AID359090 | Increase in osteopontin levels in rat primary osteoblast cells at 1 uM after 72 hrs by ELISA | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID396592 | Antileishmanial activity against Leishmania amazonensis IFLA/BR/67/PH8 promastigotes assessed as lysis of promastigotes at 100 ug/ml after 72 hrs | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Activity of a hydroxybibenzyl bryophyte constituent against Leishmania spp. and Trypanosoma cruzi: in silico, in vitro and in vivo activity studies. |
| AID1570231 | Antioxidant activity in rat H9c2 cells assessed as reduction in hypoxia-induced lipid peroxidation by measuring TBARS level preincubated for 18 hrs followed by incubated in hypoxia for 48 hrs by spectrophotometry | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors. |
| AID716919 | Antimelanogenic activity in mouse assessed as cellular melanin content B16F10 cells at 200 uM after 72 hrs spectrophotometric analysis | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID359181 | Inhibition of 2-[1,2-3H(N)]deoxy-D-glucose uptake in human HL60 cells at >100 uM by scintillation spectrometry in presence of sodium-free buffer | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3 | Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells. |
| AID1437793 | Inhibition of amyloid beta 42 (unknown origin) self aggregation at 50 uM by ThT-based fluorometric method relative to control | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease. |
| AID638160 | Bactericidal activity against CagA-expressing Helicobacter pylori G20 isolated from chronic gastritis patient compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID724576 | Binding affinity to planer lipid bilayer assessed as reduction in charge transfer resistance by admittance spectroscopic analysis | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Dose-dependent interaction of trans-resveratrol with biomembranes: effects on antioxidant property. |
| AID370921 | Inhibition of TNFalpha induced NF-kappaB activation in human 293 cells after 24 hrs by luciferase reporter gene assay | 2009 | Bioorganic & medicinal chemistry, Feb-01, Volume: 17, Issue:3 | Synthesis and biological evaluation of a library of resveratrol analogues as inhibitors of COX-1, COX-2 and NF-kappaB. |
| AID1480847 | Inhibition of human serum BuChE using butylthiocholine chloride as substrate pretreated for 15 mins followed by substrate addition measured for 2 mins by DTNB reagent based spectrophotometric method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment. |
| AID1879027 | Antifibrotic activity in CCL-4 induced liver fibrosis C57/B6J mouse model transfected with miR-190a-5p agomir assessed as reduction in serum ALT level at 100 mg/kg/day, ip measured after 72 hrs post last dose by ELISA | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID432149 | Inhibition of FSL-1-induced increase in phagocytosis of FITC-conjugated Escherichia coli K12 in human THP1 cells assessed as reduction in number of phagocytosing bacteria to total number of cells after 1 hr by CLSM | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID359190 | Blockade of rat Glut1 expressed in CHO cells assessed as inhibition of [14C]dehydroascorbic acid uptake by scintillation spectrometry | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3 | Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells. |
| AID1878987 | Inhibition of TGF-beta1 induced apoptosis in C57/B6J mouse primary hepatocytes assessed as early apoptotic cells at 25 uM by Annexin-V-FITC-H and PI staining based flow cytometry analysis (Rvb = 18.71 %) | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID1256184 | Inhibition of Quorum sensing system in Chromobacterium violaceum assessed as inhibition of violacein synthesis | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | The quorum-sensing inhibiting effects of stilbenoids and their potential structure-activity relationship. |
| AID359276 | Reversal of increase in pBMP2 expression in rat primary osteoblast cells transfected with dominant-negative mutant Src expression vector at 1 uM by luciferase method | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID359514 | Effect on MAD homolog 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID738210 | Cytotoxicity against human SKOV3 cells assessed as growth inhibition measured after 48 hrs by XTT assay | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID1399531 | Inhibition of self-induced amyloid beta (1 to 42) (unknown origin) aggregation at 20 uM after 72 hrs by thioflavin T assay relative to control | 2018 | Bioorganic & medicinal chemistry, 09-01, Volume: 26, Issue:16 | Synthesis and evaluation of 1,2,3,4-tetrahydro-1-acridone analogues as potential dual inhibitors for amyloid-beta and tau aggregation. |
| AID359515 | Effect on MAD homolog 2 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1566057 | Cytotoxicity against human SKOV3 cells transfected with shRNA assessed as reduction in cell viability incubated for 96 hrs in presence of doxycycline by MTT assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2). |
| AID432160 | Inhibition of FSL1-induced upregulation of CD36 mRNA expression in in human THP1 cells at 100 uM after 1 hr by RT-PCR | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID1314121 | Radioprotective activity in rat thymocytes assessed as radio-modification factor pretreated at 1 uM followed by 2 Gy X-ray irradiation measured after 4 hrs by flow cytometric analysis relative to control | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | A facile and rapid access to resveratrol derivatives and their radioprotective activity. |
| AID1372029 | Antioxidant activity assessed as relative scavenging rate constant for photolysis-induced super-oxide anion scavenging activity by measuring Kaox/Kst ratio using CYPMPO spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID524790 | Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay | 2009 | Nature chemical biology, Oct, Volume: 5, Issue:10 | Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. |
| AID1372025 | Antioxidant activity assessed as relative scavenging rate constant for photolysis-induced hydroxyl radical scavenging activity by measuring Kaox/Kst ratio using DMPO spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID396463 | Inhibition of melanogenesis in human dermal fibroblasts at 5 uM | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Synthesis and in vitro biological activity of retinyl polyhydroxybenzoates, novel hybrid retinoid derivatives. |
| AID359527 | Effect on homeo box msh-like 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID430018 | Antiproliferative activity against MRP1-expressing human DLKP cells assessed as cell proliferation at 10 uM after 5 days by acid phosphatase assay | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13 | Synthesis, structural characterisation and biological evaluation of fluorinated analogues of resveratrol. |
| AID359502 | Effect on FMS-like tyrosine kinase 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1311781 | Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as COX2 levels at 50 umol/L by ELISA (Rvb = 159.64 +/- 13.56 pg/mL) | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata. |
| AID1430690 | Half life in rat hepatocytes at 5 uM by LC-MS/MS analysis | 2017 | ACS medicinal chemistry letters, May-11, Volume: 8, Issue:5 | Toward Resolving the Resveratrol Conundrum: Synthesis and |
| AID1420931 | Antibiofilm activity against methicillin-resistant Staphylococcus aureus at 150 ug/ml after 18 hrs by crystal violet staining-based method relative to control | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Antibacterial and antioxidant activities for natural and synthetic dual-active compounds. |
| AID614620 | Inhibition of TPA-induced membrane translocation of PKCalpha expressed in HEK293 cells assessed as protein found in membrane fraction at 100 uM after 2 hrs by Western blotting relative to TPA | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18 | Chemical modifications of resveratrol for improved protein kinase C alpha activity. |
| AID1879485 | Antiinflammatory activity against human HaCaT cells assessed as inhibition of UVB irradiation-induced PGE2 production measured after 2 hrs by ELISA | 2022 | Journal of natural products, 03-25, Volume: 85, Issue:3 | Adiponectin-Secretion-Promoting Cyclic Peptide-Polyketide Hybrids from a Halophyte-Associated Fungus, |
| AID264600 | Induction of differentiation of human HL60 cells at 10 uM measured as expression of granulocytic marker CD11b after 4 days | 2006 | Journal of medicinal chemistry, May-18, Volume: 49, Issue:10 | Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. |
| AID359328 | Effect on procollagen 1 alpha 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1298307 | Reduction in dATP level in human U373-MAGI cells at 50 uM after 6 hrs by LC-MS/MS analysis | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID359287 | Reversal of induction of FOXO3a nuclear accumulation in human MDA-MB-231 cells transfected with constitutively activated Akt mutant | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1608145 | Binding affinity to Keap1 in rat HBZY-1 cells assessed as induction of Keap1/Nrf2 signaling by measuring increase in NQO-1 protein expression by Western blot analysis | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Synthesis and assessment of phenylacrylamide derivatives as potential anti-oxidant and anti-inflammatory agents. |
| AID474869 | Antioxidant activity assessed as galvinoxyl radical scavenging activity in methanol by UV-visible spectroscopy | 2010 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8 | Antioxidant and antiproliferative activities of hydroxyl-substituted Schiff bases. |
| AID359286 | Reversal of induction of Akt inactivation in human MDA-MB-231 cells transfected with constitutively activated Akt mutant | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID762886 | Activation of SIRT1 (unknown origin) by fluorescence assay | 2013 | Journal of natural products, Jul-26, Volume: 76, Issue:7 | trans-Resveratrol in Gnetum gnemon protects against oxidative-stress-induced endothelial senescence. |
| AID378355 | Cytotoxicity against mouse Hepa1clc7 cells after 72 hrs | 1999 | Journal of natural products, Feb, Volume: 62, Issue:2 | New bioactive flavonoids and stilbenes in cubé resin insecticide. |
| AID549848 | Displacement of fluorescent estrogen ES2 from human recombinant ERbeta by fluorescence polarization assay relative to estradiol | 2011 | Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1 | New hydroxystilbenoid derivatives endowed with neuroprotective activity and devoid of interference with estrogen and aryl hydrocarbon receptor-mediated transcription. |
| AID1081919 | Octanol-water partition coefficient, log P of the compound by HPLC analysis | 2011 | Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5 | Biological activity of peanut (Arachis hypogaea) phytoalexins and selected natural and synthetic Stilbenoids. |
| AID1499669 | Antioxidant activity in heat-inactivated Fischer-344 rat hepatic microsomes assessed as protection against against Fe2+/ascorbate-induced lipid peroxidation after 45 mins by TBAR-based spectrophotometry | 2017 | European journal of medicinal chemistry, Sep-29, Volume: 138 | Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity. |
| AID641147 | Inhibition of alpha-glucosidase activity of maltase in rat small intestinal brush border membrane fraction using maltose as substrate at 400 uM after 30 mins | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Antidiabetogenic oligostilbenoids and 3-ethyl-4-phenyl-3,4-dihydroisocoumarins from the bark of Shorea roxburghii. |
| AID403720 | Cytotoxicity against human U937 cells after 48 hrs by WST1 test | 2005 | Journal of natural products, Oct, Volume: 68, Issue:10 | Cytotoxic furostanol saponins and a megastigmane glucoside from tribulus parvispinus. |
| AID481130 | Binding affinity to Vaccinia virus recombinant N1L expressed in Escherichia coli BL21 (DE3) assessed as protein melting temperature at 214 uM by differential scanning calorimetry | 2010 | Journal of medicinal chemistry, May-27, Volume: 53, Issue:10 | Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention. |
| AID1290596 | Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production at 50 uM preincubated for 4 hrs followed by LPS stimulation for 24 hrs by Griess reaction | 2016 | European journal of medicinal chemistry, May-04, Volume: 113 | Discovery of novel sesquistilbene indanone analogues as potent anti-inflammatory agents. |
| AID1480845 | Inhibition of human erythrocyte AChE using acetylthiocholine chloride as substrate pretreated for 15 mins followed by substrate addition measured for 2 mins by DTNB reagent based spectrophotometric method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment. |
| AID359102 | Antitumor activity against human MDA-MB-231 cells xenografted in SCID mouse orthotropic model assessed as inhibition of 17beta estradiol-induced tumor formation at 10 mg/kg for 2 days | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID359280 | Reversal of increase in BMP2 expression in mouse MC3T3-E1 cells expressing small interfering RNA for FOXA1 protein at 1 uM by Western blot | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1498851 | Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 2 mins followed by substrate addition and measured after 2 mins by Ellman's method | 2018 | Bioorganic & medicinal chemistry, 07-30, Volume: 26, Issue:13 | Design, synthesis and evaluation of novel bivalent β-carboline derivatives as multifunctional agents for the treatment of Alzheimer's disease. |
| AID1362652 | Disaggregation of Cu2+ induced amyloid beta (1 to 40) preformed fibrils assessed as fluorescence emission at 100 uM after 12 days by thioflavin-T based assay (Rvb = 150.21 +/- 2.32 No_unit) | |||
| AID1872754 | Cytotoxicity against mouse C2C12 cells incubated for 24 to 48 hrs by MTT assay | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy. |
| AID1176925 | Antioxidant activity assessed as DPPH radical scavenging activity at 10 uM after 30 mins | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | Sulfonamides as multifunctional agents for Alzheimer's disease. |
| AID1362744 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by spectrophotometric method | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues. |
| AID1780360 | Activation of recombinant human SIRT3 assessed as lysyl deacetylase activity using (Gln-Pro-Lys-Lys(Ac)) peptide substrate by fluorescent assay relative to 2-butylbenzofuran-3-yl)(3,5-diiodo-4-(3-(pyrrolidin-1-yl-propoxy)pheny)methanone | |||
| AID1391984 | Inhibition of human cathepsin D using DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS as substrate preincubated for 30 mins followed by substrate addition measured every 1 min within 8 to 15 mins by FRET assay | 2018 | Bioorganic & medicinal chemistry, 05-15, Volume: 26, Issue:9 | 2-Aminoquinazolin-4(3H)-one based plasmepsin inhibitors with improved hydrophilicity and selectivity. |
| AID432147 | Inhibition of FSL-1-induced increase in phagocytosis of FITC-conjugated Staphylococcus aureus 209P in human THP1 cells using trypan blue staining after 20 mins by flow cytometry | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID1632226 | Selectivity index, ratio of CD50 against human MHRF cells to CD50 for human MDAH 2774 cells after 72 hrs | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18 | Synthesis and anticancer activity of a hydroxytolan series. |
| AID1256179 | Antibacterial activity in Pseudomonas aeruginosa PAO1 for 16 hrs | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | The quorum-sensing inhibiting effects of stilbenoids and their potential structure-activity relationship. |
| AID471948 | Growth inhibition of human KM20L2 cells after 48 hrs by sulforhodamine B assay | 2009 | Journal of natural products, Sep, Volume: 72, Issue:9 | Antineoplastic agents. 579. Synthesis and cancer cell growth evaluation of E-stilstatin 3: a resveratrol structural modification. |
| AID1700052 | Inhibition of amyloid beta (1 to 42) (unknown origin) self aggregation incubated for 48 hrs by thioflavin-T fluorescence method | 2020 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 30, Issue:24 | Novel deoxyvasicinone and tetrahydro-beta-carboline hybrids as inhibitors of acetylcholinesterase and amyloid beta aggregation. |
| AID1238824 | Drug level in human HCT116 cells treated with RAH at 20 uM after 4 to 24 hrs by HPLC-CEAD analysis | 2015 | Journal of medicinal chemistry, Aug-27, Volume: 58, Issue:16 | Novel Resveratrol-Based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer Activity. |
| AID1884058 | Antibacterial activity against Enterococcus faecalis LMG 11423 incubated for 20 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID1309173 | Antioxidant activity assessed as AAPH radical scavenging activity preincubated for 30 mins followed by AAPH addition measured after 60 mins by ORAC assay | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Ionophoric polyphenols selectively bind Cu(2+), display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila. |
| AID1182047 | Inhibition of TNF-alpha-induced NF-kappaB activity in HEK293 cells after 6 hrs by luciferase reporter gene assay | 2014 | Journal of natural products, Jul-25, Volume: 77, Issue:7 | Spongiapyridine and related spongians isolated from an Indonesian Spongia sp. |
| AID226688 | Free radical scavenging activity of DPPH was determined | 2004 | Bioorganic & medicinal chemistry letters, Jan-19, Volume: 14, Issue:2 | Syntheses and radical scavenging activities of resveratrol derivatives. |
| AID1717733 | Inhibition of human tyrosinase expressed in HEK293 cells using L-tyrosine and DOPA as substrate by absorbance method | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Advances in the Design of Genuine Human Tyrosinase Inhibitors for Targeting Melanogenesis and Related Pigmentations. |
| AID359520 | Effect on MAD homolog 7 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1566054 | Cytotoxicity against human SKOV3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2). |
| AID359281 | Reversal of increase in pBMP2 expression in mouse MC3T3-E1 cells expressing small interfering RNA for FOXA1 protein at 1 uM by luciferase method | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1333785 | Cytotoxicity against human L02 cells assessed as cell growth inhibition after 48 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1 | Synthesis and bioactivity evaluation of 2,3-diaryl acrylonitrile derivatives as potential anticancer agents. |
| AID1879010 | Inhibition of TGF-beta1 induced apoptosis in C57/B6J mouse primary hepatocytes assessed as late apoptotic cells in presence of miR-190a-5p mimic by Annexin-V-FITC-H and PI staining based flow cytometry analysis (Rvb = 12.03 %) | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID1401669 | Inhibition of triglyceride accumulation in mouse 3T3L1 cells at 1 to 10 uM after 6 days by ORO staining-based microscopic method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, syntheses and lipid accumulation inhibitory activities of novel resveratrol mimics. |
| AID416678 | Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Synthesis and biological evaluation of cytotoxic properties of stilbene-based resveratrol analogs. |
| AID1298340 | Increase in 5-aza-dCTP/dCTP ratio in human U373-MAGI cells at 50 uM preincubated for 2 hrs followed by 5-aza-dC addition measured after 4 hrs by LC-MS/MS analysis relative to 5-aza-dC | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1407192 | Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production at 10 to 30 uM after 24 hrs by Griess assay | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties. |
| AID430020 | Antiproliferative activity against MRP1-expressing human DLKP cells after 5 days by acid phosphatase assay | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13 | Synthesis, structural characterisation and biological evaluation of fluorinated analogues of resveratrol. |
| AID764638 | Cytotoxicity against human estrogen receptor positive MCF7 cells after 72 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17 | Synthesis and cytotoxic activity evaluation of 2,3-thiazolidin-4-one derivatives on human breast cancer cell lines. |
| AID1203636 | Antiproliferative activity against human MCF7 cells assessed as cell viability after 48 hrs by MTT assay | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Design, synthesis, and biological evaluation of benzoselenazole-stilbene hybrids as multi-target-directed anti-cancer agents. |
| AID1264955 | Cytotoxicity against human MSC assessed as cell viability at 10 uM treated for 3 days measured on day 4 by alamar blue assay (Rvb = 97 to 100%) | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11 | Defining Key Structural Determinants for the Pro-osteogenic Activity of Flavonoids. |
| AID1830993 | Inhibition of Saccharomyces cerevisiae alpha-glucosidase using pNPG as substrate | 2021 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 54 | Synthesis and biological evaluation of isatin derivatives containing 1,3,4-thiadiazole as potent a-glucosidase inhibitors. |
| AID271288 | Selectivity index, IC50 for ovine COX1/IC50 for ovine COX2 | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17 | Selective COX-2 inhibitors. Part 1: synthesis and biological evaluation of phenylazobenzenesulfonamides. |
| AID289281 | Relaxing effect on guinea pig terminal ileum ring assessed as reduction of force of contraction at 100 uM | 2007 | Bioorganic & medicinal chemistry, Sep-15, Volume: 15, Issue:18 | 'Bridged' stilbene derivatives as selective cyclooxygenase-1 inhibitors. |
| AID1314124 | Radioprotective activity in rat thymocytes assessed as radio-modification factor pretreated at 1000 uM followed by 2 Gy X-ray irradiation measured after 4 hrs by flow cytometric analysis relative to control | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | A facile and rapid access to resveratrol derivatives and their radioprotective activity. |
| AID1770508 | Cytotoxicity against human MCF7 cells assessed as reduction in cell metabolic activity at 100 uM incubated for 24 hrs by MTT assay relative to control | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis, structure-activity relationships and molecular docking studies of phenyldiazenyl sulfonamides as aromatase inhibitors. |
| AID724379 | Antioxidant activity in planer lipid bilayer membrane assessed as reduction in 50 uM DPPH-induced charge transfer resistance at 50 uM by admittance spectroscopic analysis | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Dose-dependent interaction of trans-resveratrol with biomembranes: effects on antioxidant property. |
| AID524796 | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | 2009 | Nature chemical biology, Oct, Volume: 5, Issue:10 | Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. |
| AID491615 | Inhibition of human recombinant COX2 assessed as PGE2 production after 10 mins by ELISA | 2010 | Journal of medicinal chemistry, Jul-08, Volume: 53, Issue:13 | Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. |
| AID1298376 | Increase in 5-aza-dCTP/dCTP ratio in human U373-MAGI cells at 50 uM preincubated for 2 hrs followed by 5-aza-C addition measured after 4 hrs by LC-MS/MS analysis relative to 5-aza-C | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1311759 | Cytotoxicity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in cell viability at 50 umol/L after 24 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata. |
| AID1220763 | Volume of distribution at steady state in C57BL/6 mouse at 15 mg/kg administered intraarterially by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Oct, Volume: 40, Issue:10 | In vivo-formed versus preformed metabolite kinetics of trans-resveratrol-3-sulfate and trans-resveratrol-3-glucuronide. |
| AID639319 | Antibacterial activity against CagA-expressing Helicobacter pylori MDO21 isolated from chronic gastritis patient after 24 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID746977 | Cytotoxicity against human HL60 cells | 2013 | Bioorganic & medicinal chemistry letters, May-15, Volume: 23, Issue:10 | A new synthesis of 4'-resveratrol esters and evaluation of the potential for anti-depressant activity. |
| AID359322 | Effect on procollagen 5 alpha 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID396590 | Antileishmanial activity against Leishmania donovani MHOM/BR/74/PP75 promastigotes assessed as lysis of promastigotes at 100 ug/ml after 72 hrs | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Activity of a hydroxybibenzyl bryophyte constituent against Leishmania spp. and Trypanosoma cruzi: in silico, in vitro and in vivo activity studies. |
| AID1352509 | Neuroprotective activity in 3-NP intoxicated C57BL/6 mouse model assessed as decrease in serum IL-6 levels at 5.5 mg/kg, ip administered for 5 days by sandwich ELISA | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Alkylated resveratrol prodrugs and metabolites as potential therapeutics for neurodegenerative diseases. |
| AID637951 | Antibacterial activity against CagA-expressing Helicobacter pylori 2Ca isolated from gastric carcinoma patient after 24 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID359337 | Effect on fibroblast growth factor 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1298442 | Potentiation of 5-Aza-dC-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as Env mutation at 50 uM incubated for 4 hrs preinfection followed by 5-Aza-C addition for 2 hrs preinfection and subseque | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1362638 | Inhibition of Cu2+ induced amyloid beta (1 to 40) fibril aggregation assessed as fluorescence emission at 100 uM measured on day 3 by thioflavin-T based assay (Rvb = 33.64 +/- 5.80 No_unit) | |||
| AID1352500 | Toxicity in 3 hrs post fertilized zebra fish AB embryo after 93 hrs | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Alkylated resveratrol prodrugs and metabolites as potential therapeutics for neurodegenerative diseases. |
| AID610238 | Antiinflammatory activity in C57BL/6J mouse model of DSS-induced colon inflammation assessed as reduction of colon TNFRp55 level at 2.1 mg/kg/day, po for 21 days followed by compound dosing for 8 days co-administered with DSS followed by 2.1 mg/kg/day, po | 2010 | Journal of medicinal chemistry, Oct-28, Volume: 53, Issue:20 | Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents. |
| AID1362761 | Inhibition of CCL-2 production in ear tissue of croton oil-induced Balb/c mouse ear edema model at 0.1 mg/ear administered topically immediately post croton oil treatment by ELISA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues. |
| AID610406 | Antiinflammatory activity in C57BL/6J mouse model of DSS-induced colon inflammation assessed as reduction in disease activity index at 2.1 mg/kg/day, po for 21 days followed by compound dosing for 8 days co-administered with DSS followed by 2.1 mg/kg/day, | 2010 | Journal of medicinal chemistry, Oct-28, Volume: 53, Issue:20 | Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents. |
| AID730554 | Antinociceptive activity in Swiss mouse assessed as inhibition of capsaicin-induced increase of COX2 expression in brain cortex at 100 mg/kg, po by Western blotting | 2013 | Journal of natural products, Jan-25, Volume: 76, Issue:1 | Evidence for the analgesic activity of resveratrol in acute models of nociception in mice. |
| AID247344 | In vitro growth inhibitory concentration against human mammary carcinoma cell line MDA MB 468 | 2005 | Journal of medicinal chemistry, Feb-24, Volume: 48, Issue:4 | Synthesis, antitumor evaluation, and apoptosis-inducing activity of hydroxylated (E)-stilbenes. |
| AID1320340 | Inhibition of 250 nM N-terminal His6-tagged recombinant human SIRT1 expressed in Escherichia coli at 100 uM using RHKK(Ac)W-NH2 as substrate after 5 to 10 mins by UV detection-based HPLC method | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20 | Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity. |
| AID359059 | Reversal of increase in DNA-binding activity of ERalpha in nuclear extracts of mouse MC3T3-E1 cells by electrophoretic mobility shift assays in presence of ICI-182780 | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1309163 | Binding affinity to Ca2+ using CaCl2 at 20 uM after 5 mins by spectrophotometry | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Ionophoric polyphenols selectively bind Cu(2+), display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila. |
| AID359057 | Increase in Src kinase phosphorylation in mouse MC3T3-E1 cells at 1 uM | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID359193 | Effect on ascorbic acid production from dehydroascorbic acid in human U937 cells at >500 uM by HPLC | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3 | Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells. |
| AID1362752 | Antiproliferative activity against LPS-induced B cells isolated from splenocytes of C57/BL6 mouse at 50 uM incubated with LPS for 1 hr followed by compound addition measured after 72 hrs by MTT assay | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues. |
| AID1533726 | Mixed type inhibition of human CYP1B1 by EROD assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Phytoestrogens and their synthetic analogues as substrate mimic inhibitors of CYP1B1. |
| AID617267 | Stability of the compound assessed as half life | 2011 | ACS medicinal chemistry letters, Jan-25, Volume: 2, Issue:4 | The Use of 3,5,4'-Tri-O-acetylresveratrol as a Potential Pro-drug for Resveratrol Protects Mice from γ-Irradiation-Induced Death. |
| AID340409 | Inhibition of LPS-stimulated NO release in rat cortical microglial cells assessed as nitrite accumulation after 48 hrs | 2008 | Journal of natural products, Jul, Volume: 71, Issue:7 | Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia. |
| AID725945 | Inhibition of recombinant firefly luciferase at 10 uM after 20 mins by luminescence assay | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Discovery of 5-benzyl-3-phenyl-4,5-dihydroisoxazoles and 5-benzyl-3-phenyl-1,4,2-dioxazoles as potent firefly luciferase inhibitors. |
| AID1385436 | Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay | 2018 | Journal of medicinal chemistry, 09-27, Volume: 61, Issue:18 | Novel Hybrid Conjugates with Dual Suppression of Estrogenic and Inflammatory Activities Display Significantly Improved Potency against Breast Cancer. |
| AID432241 | Inhibition of phagocytosis of FITC-conjugated Staphylococcus aureus 209P in human THP1 cells using trypan blue staining after 60 mins by flow cytometry | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID1362648 | Inhibition of self-induced amyloid beta (1 to 40) (unknown origin) fibril aggregation assessed as fluorescence emission at 100 uM measured on day 10 by thioflavin-T based assay (Rvb = 408.94 +/- 32 No_unit) | |||
| AID1700051 | Inhibition of human serum BuChe by Ellman's method | 2020 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 30, Issue:24 | Novel deoxyvasicinone and tetrahydro-beta-carboline hybrids as inhibitors of acetylcholinesterase and amyloid beta aggregation. |
| AID1362642 | Inhibition of Cu2+ induced amyloid beta (1 to 40) fibril aggregation assessed as fluorescence emission at 100 uM measured on day 10 by thioflavin-T based assay (Rvb = 412.11 +/- 35.93 No_unit) | |||
| AID1220760 | AUC (0 to t) in C57BL/6 mouse at 15 mg/kg administered intraarterially by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Oct, Volume: 40, Issue:10 | In vivo-formed versus preformed metabolite kinetics of trans-resveratrol-3-sulfate and trans-resveratrol-3-glucuronide. |
| AID340411 | Inhibition of LPS-stimulated NO release in rat cortical microglial cells assessed as nitrite accumulation at 3 uM after 48 hrs relative to LPS | 2008 | Journal of natural products, Jul, Volume: 71, Issue:7 | Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia. |
| AID1298417 | Potentiation of 5-Aza-C-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as reduction in gag level at 50 uM after 2 to 72 hrs by qPCR method | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1879009 | Inhibition of TGF-beta1 induced apoptosis in C57/B6J mouse primary hepatocytes assessed as early apoptotic cells in presence of miR-190a-5p mimic by Annexin-V-FITC-H and PI staining based flow cytometry analysis (Rvb = 19.89 %) | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID637952 | Antibacterial activity against CagA-deficient Helicobacter pylori G50 isolated from chronic gastritis patient after 48 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1054185 | Antiviral activity against HIV1 infected in human U373-MAGI cells assessed as T to C mutation at 50 uM (Rvb = 18%) | 2013 | Bioorganic & medicinal chemistry, Nov-15, Volume: 21, Issue:22 | 5,6-Dihydro-5-aza-2'-deoxycytidine potentiates the anti-HIV-1 activity of ribonucleotide reductase inhibitors. |
| AID359179 | Inhibition of 2-[1,2-3H(N)]deoxy-D-glucose uptake in human HL60 cells at >500 uM by scintillation spectrometry in presence of buffer containing NaCl and Na2HPO4 | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3 | Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells. |
| AID699921 | Antiviral activity against HIV1 infected in human U373-MAGI cells expressing CXCR4 assessed as inhibition of viral infection preincubated for 2 hrs prior to infection followed by compound wash out measured after 48 hrs by single round replication assay | 2012 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 22, Issue:21 | Anti-HIV-1 activity of resveratrol derivatives and synergistic inhibition of HIV-1 by the combination of resveratrol and decitabine. |
| AID1298360 | Potentiation of 5-Aza-C-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as reduction in U5-gag level at 50 uM after 2 to 72 hrs by qPCR method | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID610236 | Antiinflammatory activity in C57BL/6J mouse model of DSS-induced colon inflammation assessed as reduction in morphological signs of cell damage at 2.1 mg/kg/day, po for 21 days followed by compound dosing for 8 days co-administered with DSS followed by 2. | 2010 | Journal of medicinal chemistry, Oct-28, Volume: 53, Issue:20 | Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents. |
| AID359113 | Increase in BMP2 expression in mouse MC3T3-E1 cells expressing pBMP2delta1 mutant at 1 uM after 4 hrs by luciferase method relative to control | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1498852 | Selectivity index, ratio of IC50 for electric eel AChE to IC50 for equine serum BChE | 2018 | Bioorganic & medicinal chemistry, 07-30, Volume: 26, Issue:13 | Design, synthesis and evaluation of novel bivalent β-carboline derivatives as multifunctional agents for the treatment of Alzheimer's disease. |
| AID311534 | Antibacterial activity against Helicobacter pylori ATCC 43504 by agar dilution method | 2007 | Journal of natural products, Oct, Volume: 70, Issue:10 | Anti-Helicobacter pylori and thrombin inhibitory components from Chinese dragon's blood, Dracaena cochinchinensis. |
| AID1430676 | Cmax in CD rat at 50 mg/kg/day, po administered via gavage every 24 hrs for 14 consecutive days measured on day 14 post dose by HPLC-MS analysis | 2017 | ACS medicinal chemistry letters, May-11, Volume: 8, Issue:5 | Toward Resolving the Resveratrol Conundrum: Synthesis and |
| AID1264953 | Cytotoxicity against human MSC assessed as cell viability at 1 uM treated for 3 days measured on day 4 by alamar blue assay (Rvb = 97 to 100%) | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11 | Defining Key Structural Determinants for the Pro-osteogenic Activity of Flavonoids. |
| AID359551 | Effect on actin beta gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID528474 | Binding affinity to beta-amyloid plaque in APP/PS1 transgenic mouse brain assessed as signal-to-noise ratio after 30 mins by DAPI staining | 2010 | Journal of medicinal chemistry, Nov-25, Volume: 53, Issue:22 | Phenolic bis-styrylbenzenes as β-amyloid binding ligands and free radical scavengers. |
| AID730571 | Antinociceptive activity in Swiss mouse assessed as inhibition of capsaicin-induced spontaneous nociception at 100 mg/kg, po | 2013 | Journal of natural products, Jan-25, Volume: 76, Issue:1 | Evidence for the analgesic activity of resveratrol in acute models of nociception in mice. |
| AID359185 | Inhibition of [14C]dehydroascorbic acid uptake in human HL60 cells at 32 uM by scintillation spectrometry in presence of buffer containing NaCl and Na2HPO4 | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3 | Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells. |
| AID1168361 | Hepatoprotective activity against isoniazid-rifampicin induced liver injury in BALB/c mouse assessed as prevention of liver statosis development at 100 mg/kg, po bid for 3 days starting 30 mins prior isoniazid-rifampicin administration measured 24 hrs pos | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. |
| AID416966 | Inhibition of hydrogen peroxide-induced DNA fragmentation in BALB/c mouse thymocytes at 100 uM preincubated for 30 mins before hydrogen peroxide challenge measured after 6 hrs | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7 | Antioxidant-based lead discovery for cancer chemoprevention: the case of resveratrol. |
| AID1306443 | Inhibition of recombinant human CYP1B1 expressed in Escherichia coli DH5aplha cells assessed as O-deethylation of ethoxyresorufin in presence of NADPH measured after 2 mins by spectrofluorometric method | 2016 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 26, Issue:14 | Aryl morpholino triazenes inhibit cytochrome P450 1A1 and 1B1. |
| AID1298315 | Effect on 5-aza-dCTP level in human U373-MAGI cells at 50 uM preincubated for 2 hrs followed by 5-aza-dC addition measured after 4 hrs by LC-MS/MS analysis | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1428605 | Binding affinity to Fe3+ assessed as disaggregation of Fe3+-induced amyloid beta (1 to 42) aggregation by measuring Fe3+-amyloid beta (1 to 42) complex fluorescence at 50 uM treated 24 hrs after Fe3+ addition measured after 24 hrs incubation under dark co | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Synthesis and biological evaluation of deferiprone-resveratrol hybrids as antioxidants, Aβ |
| AID718774 | Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 60 uM after 48 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Design, synthesis, and evaluation of resveratrol derivatives as Aß(₁-₄₂) aggregation inhibitors, antioxidants, and neuroprotective agents. |
| AID528480 | Antioxidant activity assessed as DPPH radical scavenging activity by spectrophotometric analysis | 2010 | Journal of medicinal chemistry, Nov-25, Volume: 53, Issue:22 | Phenolic bis-styrylbenzenes as β-amyloid binding ligands and free radical scavengers. |
| AID1311775 | Inhibition of NFkappaB signaling pathway in LPS-stimulated mouse RAW264.7 cells assessed as protein levels at 5 umol/L by ELISA (Rvb = 1.23 +/- 0.06 pg/mL) | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata. |
| AID359289 | Enhancement of Akt inactivation in human MDA-MB-231 cells transfected with dominant negative Akt mutant | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1611505 | Thermal stability of compound in DMSO/methanol assessed as decomposition temperature by UV spectroscopic method | 2019 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 29, Issue:24 | Synthesis and evaluation of 1,3,5-triazine derivatives as sunscreens useful to prevent skin cancer. |
| AID340406 | Inhibition of NO release in rat cortical microglial cells | 2008 | Journal of natural products, Jul, Volume: 71, Issue:7 | Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia. |
| AID641063 | Antihyperglycemic activity in ddY mouse assessed as inhibition of sucrose-induced increase in plasma glucose level at 100 mg/kg, po administered 30 mins before sucrose challenge measured after 2 hrs (Rvb = 160.8 +/- 3.5 mg/dl) | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Antidiabetogenic oligostilbenoids and 3-ethyl-4-phenyl-3,4-dihydroisocoumarins from the bark of Shorea roxburghii. |
| AID416970 | Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7 | Antioxidant-based lead discovery for cancer chemoprevention: the case of resveratrol. |
| AID1437790 | Inhibition of butyrylcholinesterase isolated from human plasma up to 100 uM using butyrylthiocholine as substrate preincubated for 5 mins followed by substrate addition measured every 2 mins by Ellman's method | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease. |
| AID1281398 | Inhibition of human recombinant NQO2 using DCPIPas substrate and NRH as cofactor measured for 1 min by spectrophotometry in the prsence of BSA | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Non-symmetrical furan-amidines as novel leads for the treatment of cancer and malaria. |
| AID1452017 | Inhibition of human TTR V30M mutant expressed in Escherichia coli BL-21 assessed as fibril formation at 14.2 uM incubated for 30 mins measured after 96 hrs by light scattering method relative to control | 2017 | Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18 | Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation. |
| AID1470911 | Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate measured at 12 secs interval for 10 mins by Ellman's method | 2017 | European journal of medicinal chemistry, May-26, Volume: 132 | Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease. |
| AID432200 | ABTS radical scavenging activity assessed as Trolox equivalent antioxidant capacity index at pH 7 by spectrophotometry | 2009 | Journal of natural products, Jun, Volume: 72, Issue:6 | The role of phenolic hydroxy groups in the free radical scavenging activity of betalains. |
| AID1083160 | Antifungal activity against Neofusicoccum luteum CBS110299 assessed as growth inhibition measured after 1 to 10 days | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID1485921 | Metal chelating activity assessed as inhibition of Cu2+-induced amyloid beta (1 to 42 residues) aggregation at 50 uM after 24 hrs by thioflavin-T fluorescence assay (Rvb = 142%) | 2017 | Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14 | Synthesis and pharmacological evaluation of novel chromone derivatives as balanced multifunctional agents against Alzheimer's disease. |
| AID359118 | Reversal of induction in ER.DNA complex in mouse MC3T3-E1 cells at 1 uM by RT-PCR in presence of tamoxifen | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID655175 | Cell cycle arrest in human HepG2 cells assessed as accumulation at G2/M phase at 50 uM after 24 hrs by FACS analysis (Rvb = 16.8 %) | 2012 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5 | A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. |
| AID359112 | Increase in BMP2 expression in mouse MC3T3-E1 cells expressing pBMP2 mutant at 1 uM after 4 hrs by luciferase method relative to control | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1311914 | Inhibition of electric eel ACHE preincubated for 6 mins followed by addition of acetylcholine iodide as substrate by Ellman's method | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18 | Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin. |
| AID1608172 | Binding affinity to Keap1 in rat HBZY-1 cells assessed as induction of Keap1/Nrf2 signaling by measuring increase in NQO-1 mRNA expression at 6 uM by RT-PCR analysis | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Synthesis and assessment of phenylacrylamide derivatives as potential anti-oxidant and anti-inflammatory agents. |
| AID610237 | Antiinflammatory activity in C57BL/6J mouse model of DSS-induced colon inflammation assessed as preservation of mucosal architecture at 2.1 mg/kg/day, po for 21 days followed by compound dosing for 8 days co-administered with DSS followed by 2.1 mg/kg/day | 2010 | Journal of medicinal chemistry, Oct-28, Volume: 53, Issue:20 | Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents. |
| AID1718906 | Cytotoxicity against human MG-63 cells incubated for 48 hrs by CCK-8 assay | 2020 | Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24 | Cancer Stem Cell (CSC) Inhibitors in Oncology-A Promise for a Better Therapeutic Outcome: State of the Art and Future Perspectives. |
| AID1372022 | Antioxidant activity assessed as Trolox equivalents of photolysis-induced peroxyl scavenging activity using CYPMPO spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID1383207 | Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins followed by LPS stimulation and measured after 24 hrs by Griess assay | 2018 | European journal of medicinal chemistry, Apr-10, Volume: 149 | Design, synthesis, and biological evaluation of compounds with a new scaffold as anti-neuroinflammatory agents for the treatment of Alzheimer's disease. |
| AID305160 | Inhibition of mushroom tyrosinase | 2007 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2 | Syntheses of hydroxy substituted 2-phenyl-naphthalenes as inhibitors of tyrosinase. |
| AID1632201 | Cytotoxicity against human MHRF cells after 48 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18 | Synthesis and anticancer activity of a hydroxytolan series. |
| AID359067 | Increase in BMP2 expression in mouse MC3T3-E1 cells expressing pBMP2delta3 mutant at 1 uM after 4 hrs by luciferase method relative to control | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID432166 | Inhibition of phagocytosis of FITC-conjugated Staphylococcus aureus 209P in mouse RAW264.7 cells using trypan blue staining after 20 mins by flow cytometry | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID738180 | Inhibition of Notch signaling pathway in human HeLa cells assessed as measured as lowest concentration required 50 to 60 % inhibition of PMA induced luciferase treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID1365629 | Inhibition of self-induced aggregation of amyloid beta (1 to 42 residues) (unknown origin) at 25 uM incubated for 48 hrs by Thioflavin T fluorescence assay relative to control | 2017 | Bioorganic & medicinal chemistry, 11-01, Volume: 25, Issue:21 | Design, synthesis, and evaluation of salicyladimine derivatives as multitarget-directed ligands against Alzheimer's disease. |
| AID1083171 | Antifungal activity against Togninia minima SO21 assessed as susceptibility at 500 uM measured after 1 to 10 days | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID1450151 | Growth inhibition of human Ramos cells after 2 days by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11 | One drug for two targets: Biological evaluation of antiretroviral agents endowed with antiproliferative activity. |
| AID1168371 | Hepatoprotective activity against isoniazid-rifampicin induced liver injury in BALB/c mouse assessed as change in SIRT7 mRNA level at 100 mg/kg, po bid for 3 days starting 30 mins prior isoniazid-rifampicin administration measured 24 hrs post-last dose of | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. |
| AID359507 | Effect on insulin-like growth factor 1 receptor gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID455038 | Cytotoxicity against human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay | 2009 | Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18 | E-Combretastatin and E-resveratrol structural modifications: antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes. |
| AID294483 | Induction of quinone reductase activity in mouse Hepa 1c1c7 cells at 25 uM after 24 hrs relative to control | 2007 | European journal of medicinal chemistry, Jun, Volume: 42, Issue:6 | Quinone reductase induction activity of methoxylated analogues of resveratrol. |
| AID359293 | Induction of FOXO3a nuclear accumulation in human MDA-MB-231 cells FOXO3a-specific small interfering RNA xenografted in nude mice at 10 mg/kg for 2 days | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID510869 | Cytotoxicity against human Caco-2 cells after 3 days by [3H]thymidine incorporation assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer. |
| AID549839 | Cytotoxicity against human Ishikawa cells by LDH release assay | 2011 | Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1 | New hydroxystilbenoid derivatives endowed with neuroprotective activity and devoid of interference with estrogen and aryl hydrocarbon receptor-mediated transcription. |
| AID360099 | Inhibition of antiapoptotic activity in mouse MC3T3-E1 cells at 1 uM after 48 hrs in presence of noggin | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1401670 | Cytotoxicity against HEK293T cells after 24 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, syntheses and lipid accumulation inhibitory activities of novel resveratrol mimics. |
| AID1318721 | Neuroprotective activity against glutamate-induced toxicity in human SK-N-SH cells assessed as cell viability at 10 uM after 24 hrs by MTT assay (Rvb = 61.9 +/- 0.9%) | 2016 | Journal of natural products, 06-24, Volume: 79, Issue:6 | Polycyclic Polyprenylated Acylphloroglucinol Congeners from Hypericum scabrum. |
| AID738199 | Inhibition of Stat3 signaling pathway in human HeLa cells assessed as inhibition of IL-6 induced luciferase treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID1557205 | Binding affinity to Streptococcus mutans GtfB | 2019 | MedChemComm, Jul-01, Volume: 10, Issue:7 | Targeting |
| AID638157 | Bactericidal activity against CagA-expressing Helicobacter pylori Ma01 isolated from chronic gastritis patient compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1054208 | Selectivity index, ratio of CC50 for human U373-MAGI cells to EC50 for HIV1 infected in human U373-MAGI cells | 2013 | Bioorganic & medicinal chemistry, Nov-15, Volume: 21, Issue:22 | 5,6-Dihydro-5-aza-2'-deoxycytidine potentiates the anti-HIV-1 activity of ribonucleotide reductase inhibitors. |
| AID1362641 | Inhibition of Cu2+ induced amyloid beta (1 to 40) fibril aggregation assessed as aggregation level at 100 uM measured on day 7 by UV-visible turbidity method (Rvb = 100 +/- 0.96%) | |||
| AID650845 | Induction of QR1 in mouse Hepa-1c1c7 cells assessed as induction ratio at 50 uM by MTT assay | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7 | Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol. |
| AID713112 | Drug metabolism assessed as oxidation of the compound at 100 uM by HPLC analysis in the presence of tyrosinase | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID1347859 | Growth inhibition of human A375 cells at 25 uM after 48 hrs by SRB assay relative to control | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, synthesis and evaluation of novel dihydrostilbene derivatives as potential anti-melanogenic skin-protecting agents. |
| AID1362661 | Cytotoxicity against human HEK293 cells assessed as decrease in cell viability after 48 hrs by MTT assay | |||
| AID1331320 | Antioxidant activity assessed as DPPH radical scavenging activity at 10 uM | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2 | Synthesis and application of β-carbolines as novel multi-functional anti-Alzheimer's disease agents. |
| AID730569 | Antinociceptive activity in Swiss mouse assessed as inhibition of glutamate-induced spontaneous nociception at 200 ug/site, administered as intraplantarly | 2013 | Journal of natural products, Jan-25, Volume: 76, Issue:1 | Evidence for the analgesic activity of resveratrol in acute models of nociception in mice. |
| AID730570 | Antinociceptive activity in Swiss mouse assessed as inhibition of glutamate-induced spontaneous nociception at 100 mg/kg, po | 2013 | Journal of natural products, Jan-25, Volume: 76, Issue:1 | Evidence for the analgesic activity of resveratrol in acute models of nociception in mice. |
| AID1362748 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-6 production by measuring IL-6 levels incubated with LPS for 1 hr followed by compound addition measured after 48 hrs by ELISA (Rvb = 2.9 +/- 0.3 ng/ml) | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues. |
| AID1430685 | AUC (0 to last) in Wistar rat at 20 mg/kg, po by HPLC-MS analysis | 2017 | ACS medicinal chemistry letters, May-11, Volume: 8, Issue:5 | Toward Resolving the Resveratrol Conundrum: Synthesis and |
| AID614082 | Antibacterial activity against Enterobacter dissolvens ATCC 222 at 10 mg/ml after 24 to 72 hrs by agar diffusion method | 2011 | Bioorganic & medicinal chemistry, Sep-01, Volume: 19, Issue:17 | Synthesis and antimicrobial activity of (E) stilbene derivatives. |
| AID471947 | Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay | 2009 | Journal of natural products, Sep, Volume: 72, Issue:9 | Antineoplastic agents. 579. Synthesis and cancer cell growth evaluation of E-stilstatin 3: a resveratrol structural modification. |
| AID639323 | Antibacterial activity against CagA-expressing Helicobacter pylori Ma01 isolated from chronic gastritis patient after 24 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1699026 | Inhibition of quorum sensing system in Proteus mirabilis | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Next generation quorum sensing inhibitors: Accounts on structure activity relationship studies and biological activities. |
| AID759461 | Inhibition of self-mediated amyloid beta (1 to 42) aggregation (unknown origin) at 20 uM after 48 hrs by thioflavin T fluorescence assay relative to control | 2013 | Journal of medicinal chemistry, Jul-25, Volume: 56, Issue:14 | Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease. |
| AID297566 | Selectivity for ERbeta over ERalpha | 2007 | Journal of medicinal chemistry, Sep-06, Volume: 50, Issue:18 | Design, synthesis, and estrogenic activity of a novel estrogen receptor modulator--a hybrid structure of 17beta-estradiol and vitamin E in hippocampal neurons. |
| AID400267 | Blockade of inward rectifier potassium channel in mouse rat hybrid F11 cells at 90 uM by whole-cell patch clamp technique | 2004 | Journal of natural products, Mar, Volume: 67, Issue:3 | Resveratrol derivatives and their role as potassium channels modulators. |
| AID432144 | Inhibition of FSL-1-induced increase in phagocytosis of FITC-conjugated Escherichia coli K12 in mouse RAW264.7 cells using trypan blue staining after 20 mins by flow cytometry | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID655173 | Cell cycle arrest in human HepG2 cells assessed as accumulation at G0/G1 phase at 50 uM after 24 hrs by FACS analysis (Rvb = 53.7 %) | 2012 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5 | A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. |
| AID331067 | Reduction of blood glucose level in diabetic Lep ob/ob mouse model at 1000 mg/kg, po after 3 weeks | 2007 | Nature, Nov-29, Volume: 450, Issue:7170 | Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. |
| AID1396266 | Antiproliferative activity against human CAR cells after 48 hrs by MTT assay | 2018 | Bioorganic & medicinal chemistry, 08-07, Volume: 26, Issue:14 | Synthesis and antitumor activity of bis(hydroxymethyl)propionate analogs of pterostilbene in cisplatin-resistant human oral cancer cells. |
| AID359547 | Effect on PUC18 plasmid DNA gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1065382 | Antimicrobial activity against Candida albicans SC5314 after 24 hrs by microbroth dilution method | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Small azobenzene derivatives active against bacteria and fungi. |
| AID359056 | Reversal of increase in Src kinase phosphorylation in mouse MC3T3-E1 cells transfected with dominant-negative mutant Src expression vector at 1 uM | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID227508 | Free radical scavenging activity of DPPH expressed as percent polyphenol | 2004 | Bioorganic & medicinal chemistry letters, Jan-19, Volume: 14, Issue:2 | Syntheses and radical scavenging activities of resveratrol derivatives. |
| AID359534 | Effect on transforming growth factor beta 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID650846 | Induction of QR1 in mouse Hepa-1c1c7 cells assessed as concentration required to double QR1 induction by MTT assay | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7 | Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol. |
| AID1225526 | Reduction in COX2 expression in prostate tissue in BPH-induced Sprague-Dawley rat model at 1 mg/kg, ip daily for 4 weeks by Western blot analysis | 2015 | Journal of natural products, Apr-24, Volume: 78, Issue:4 | Effects of resveratrol on benign prostatic hyperplasia by the regulation of inflammatory and apoptotic proteins. |
| AID725947 | Inhibition of recombinant firefly luciferase after 20 mins by luminescence assay | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Discovery of 5-benzyl-3-phenyl-4,5-dihydroisoxazoles and 5-benzyl-3-phenyl-1,4,2-dioxazoles as potent firefly luciferase inhibitors. |
| AID1884103 | Antibacterial activity against Bacillus cereus ATCC 10987 assessed as membrane potential change at 0.5 to 2X MIC incubated for 20 mins by DiSC3(5) staining based assay | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID1311763 | Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as IL1beta levels at 5 umol/L by ELISA (Rvb = 8.70 +/- 0.365 pg/mL) | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata. |
| AID1467685 | Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addition measured for 1 min by Fluo-4 dye-based assay | 2017 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14 | Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor. |
| AID1420926 | Antibacterial activity against Arcobacter cryaerophilus after 17 hrs by NCCLS broth microdilution method | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Antibacterial and antioxidant activities for natural and synthetic dual-active compounds. |
| AID1632219 | Selectivity index, ratio of CD50 against human MHRF cells to CD50 for human T24 cells after 24 hrs | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18 | Synthesis and anticancer activity of a hydroxytolan series. |
| AID1881912 | Inhibition of PKM2 (unknown origin) Gly128, Hie78, Ser77, Asn75, Ile51, Ser362 residues | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2 | A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2. |
| AID620775 | Antiproliferative activity against human HeLa cells assessed as cell viability after 48 hrs by SRB assay | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | Design and synthesis of resveratrol-based nitrovinylstilbenes as antimitotic agents. |
| AID1651380 | Upregulation of SIRT1 mRNA expression in mouse C2C12 cells at 50 uM measured after 24 hrs by qRT-PCR analysis | 2020 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 30, Issue:4 | Mariannamides A and B, new cyclic octapeptides isolated from Mariannaea elegans NBRC102301. |
| AID1772553 | Toxicity in 3hpf zebrafish AB embryo assessed as median lethal dose measured 96 hpf | 2021 | European journal of medicinal chemistry, Nov-05, Volume: 223 | Silyl resveratrol derivatives as potential therapeutic agents for neurodegenerative and neurological diseases. |
| AID1357646 | Lipid lowering activity in zebrafish embryos 50 uM by Nile red fat metabolism assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Lipid reducing activity and toxicity profiles of a library of polyphenol derivatives. |
| AID730558 | Antinociceptive activity in Swiss mouse assessed as inhibition of glutamate-induced increase of COX2 expression in spinal cord and cortex brain section at 100 mg/kg, po by Western blotting | 2013 | Journal of natural products, Jan-25, Volume: 76, Issue:1 | Evidence for the analgesic activity of resveratrol in acute models of nociception in mice. |
| AID1238814 | Cytotoxicity against human HCT116 cells assessed as inhibition of cell growth after 24 hrs by MTT assay | 2015 | Journal of medicinal chemistry, Aug-27, Volume: 58, Issue:16 | Novel Resveratrol-Based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer Activity. |
| AID977599 | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID1168363 | Hepatoprotective activity against isoniazid-rifampicin induced liver injury in BALB/c mouse assessed as reduction in MCP-1 level at 100 mg/kg, po bid for 3 days starting 30 mins prior isoniazid-rifampicin administration measured 24 hrs post-last dose of i | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. |
| AID718771 | Neuroprotective activity in human SH-SY5Y cells assessed as decrease in tertiary butylhydroperoxide-induced radical formation incubated for 24 hrs prior to tertiary butylhydroperoxide challenge measured after 30 mins by DCFH-DA staining-based fluorescence | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Design, synthesis, and evaluation of resveratrol derivatives as Aß(₁-₄₂) aggregation inhibitors, antioxidants, and neuroprotective agents. |
| AID1872742 | Antioxidant activity assessed as galvinoxyl radical scavenging activity measured after 20 mins | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy. |
| AID1362644 | Inhibition of self-induced amyloid beta (1 to 40) (unknown origin) fibril aggregation assessed as fluorescence emission at 100 uM measured on day 3 by thioflavin-T based assay (Rvb = 251.22 +/- 0.35 No_unit) | |||
| AID1420916 | Antibacterial activity against Staphylococcus aureus after 17 hrs by NCCLS broth microdilution method | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Antibacterial and antioxidant activities for natural and synthetic dual-active compounds. |
| AID1371371 | Cytotoxicity against human COLO201 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID610240 | Antiinflammatory activity in C57BL/6J mouse model of DSS-induced colon inflammation assessed as reduction of colon MIG level at 2.1 mg/kg/day, po for 21 days followed by compound dosing for 8 days co-administered with DSS followed by 2.1 mg/kg/day, po dos | 2010 | Journal of medicinal chemistry, Oct-28, Volume: 53, Issue:20 | Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents. |
| AID1420920 | Antibacterial activity against Escherichia coli after 17 hrs by NCCLS broth microdilution method | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Antibacterial and antioxidant activities for natural and synthetic dual-active compounds. |
| AID359317 | Effect on procollagen 6 alpha 2 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID432242 | Inhibition of phagocytosis of FITC-conjugated Staphylococcus aureus 209P in human THP1 cells using trypan blue staining after 80 mins by flow cytometry | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID432132 | Inhibition of phagocytosis of FITC-conjugated Escherichia coli K12 in mouse RAW264.7 cells using trypan blue staining after 20 mins by flow cytometry | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID1372027 | Antioxidant activity assessed as relative scavenging rate constant for photolysis-induced alkoxyl scavenging activity by measuring Kaox/Kst ratio using DMPO spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID271286 | Inhibition of ovine COX1 | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17 | Selective COX-2 inhibitors. Part 1: synthesis and biological evaluation of phenylazobenzenesulfonamides. |
| AID735502 | Activation of SIRT1 R446A mutant (unknown origin) at 50 uM relative to control | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate. |
| AID654115 | Antioxidant activity assessed as scavenging of DPPH at 160 uM after 30 mins by spectrophotometry | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8 | Free radical scavenging and antiproliferative properties of Biginelli adducts. |
| AID491518 | Chemical stability assessed as degradation after 24 hrs by LC/MS/MS analysis | 2010 | Journal of medicinal chemistry, Jul-08, Volume: 53, Issue:13 | Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. |
| AID639243 | Antibacterial activity against CagA-deficient Helicobacter pylori NS23 isolated from chronic gastritis patient after 24 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1225522 | Reduction in 5alpha-reductase mRNA level in prostate tissue in BPH-induced Sprague-Dawley rat model at 1 mg/kg, ip daily for 4 weeks by quantitative real-time PCR analysis | 2015 | Journal of natural products, Apr-24, Volume: 78, Issue:4 | Effects of resveratrol on benign prostatic hyperplasia by the regulation of inflammatory and apoptotic proteins. |
| AID1203641 | Cell cycle arrest in human Bel7402 cells assessed as cells accumulation at Sub-G1 phase at 50 uM after 48 hrs by flow cytometry (Rvb = 1.47%) | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Design, synthesis, and biological evaluation of benzoselenazole-stilbene hybrids as multi-target-directed anti-cancer agents. |
| AID713106 | Activation of mushroom tyrosinase assessed as oxygen consumption using L-tyrosine substrate after 60 mins | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID1683647 | Antiinflammatory activity against LPS-induced mouse BV-2 cells assessed NO production at 1 uM preincubated for 2 hrs followed by LPS-stimulation and measured after 24 hrs by Greiss reagent based assay relative to control | 2020 | Journal of natural products, 12-24, Volume: 83, Issue:12 | Neuroprotective and Anti-inflammatory Ditetrahydrofuran-Containing Diarylheptanoids from |
| AID1594638 | Cytoprotective effect against high glucose-induced oxidative stress in HUVEC assessed as cell viability at 1 uM incubated by MTT assay (Rvb = 72.1 to 77.9%) | 2019 | Journal of natural products, 06-28, Volume: 82, Issue:6 | Isolation, Chiral-Phase Resolution, and Determination of the Absolute Configurations of a Complete Series of Stereoisomers of a Rearranged Acetophenone with Three Stereocenters. |
| AID639330 | Antibacterial activity against CagA-expressing Helicobacter pylori 17C7 isolated from gastric carcinoma patient after 24 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1550779 | Antioxidant activity in human MCF7 cells assessed as decrease in reactive oxygen species generation at 100 uM incubated for 24 hrs by CellROX green/Hoechst 33342 staining based assay | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Anticancer activity of the thiosemicarbazones that are based on di-2-pyridine ketone and quinoline moiety. |
| AID1168358 | Hepatoprotective activity against isoniazid-rifampicin induced liver injury in BALB/c mouse assessed as reduction in hepatic myeloperoxidase activity at 100 mg/kg, po bid for 3 days starting 30 mins prior isoniazid-rifampicin administration measured 24 hr | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. |
| AID432158 | Inhibition of heat killed Staphylococcus aureus 209P-induced TNF alpha production in human THP1 cells at 1 to 100 uM after 6 hrs by ELISA | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID1884055 | Antibacterial activity against Enterococcus faecalis LMG 08222 incubated for 20 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID331053 | Activation of human SIRT1-G (235-664) construct by mass spectrometry assay relative to control | 2007 | Nature, Nov-29, Volume: 450, Issue:7170 | Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. |
| AID1392707 | Inhibition of HFIP-pretreated amyloid beta (1 to 42) (unknown origin) self-induced aggregation after 48 hrs by thioflavin T-based fluorometric assay | |||
| AID692940 | Cytotoxicity against human SW480 cells at 10 uM for 2 days by vi-cell cell viability analysis | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID1314126 | Toxicity in rat thymocytes assessed as increase in cell death at 10 uM measured after 4 hrs by flow cytometric analysis relative to control | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | A facile and rapid access to resveratrol derivatives and their radioprotective activity. |
| AID726366 | Antioxidant activity assessed as DPPH radical scavenging activity at 25 uM after 30 mins by spectrophotometry | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Antioxidant activities of thiosemicarbazones from substituted benzaldehydes and N-(tetra-O-acetyl-β-D-galactopyranosyl)thiosemicarbazide. |
| AID1485915 | Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using p-tyramine as substrate pretreated for 15 mins followed by substrate addition after 20 mins by Amplex red reagent based fluorimetric method | 2017 | Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14 | Synthesis and pharmacological evaluation of novel chromone derivatives as balanced multifunctional agents against Alzheimer's disease. |
| AID420375 | Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupole mass spectrometry | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15 | Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. |
| AID738188 | Inhibition of E2F signaling pathway in human HeLa cells assessed as inhibition of PMA induced luciferase at 100 uM treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID331048 | Activation of human SIRT1-B (172-664) construct by mass spectrometry assay relative to control | 2007 | Nature, Nov-29, Volume: 450, Issue:7170 | Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. |
| AID416963 | Antioxidant effect assessed as inhibition of AAPH-induced oxidative pBR322 plasmid DNA strand breakage by gel electrophoresis | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7 | Antioxidant-based lead discovery for cancer chemoprevention: the case of resveratrol. |
| AID332217 | Inhibition of COX1 | 2002 | Journal of natural products, Feb, Volume: 65, Issue:2 | Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity. |
| AID359304 | Effect on bone morphogenetic protein 4 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1452014 | Inhibition of human wild type TTR expressed in Escherichia coli BL-21 assessed as fibril formation at 7.2 uM incubated for 30 mins measured after 96 hrs by light scattering method relative to control | 2017 | Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18 | Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation. |
| AID641148 | Inhibition of alpha-glucosidase activity of sucrase in rat small intestinal brush border membrane fraction using maltose as substrate after 30 mins | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Antidiabetogenic oligostilbenoids and 3-ethyl-4-phenyl-3,4-dihydroisocoumarins from the bark of Shorea roxburghii. |
| AID1298285 | Reduction in dTTP level in human U373-MAGI cells at 200 uM after 6 hrs by LC-MS/MS analysis | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID726363 | Antioxidant activity assessed as DPPH radical scavenging activity at 200 uM after 30 mins by spectrophotometry | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Antioxidant activities of thiosemicarbazones from substituted benzaldehydes and N-(tetra-O-acetyl-β-D-galactopyranosyl)thiosemicarbazide. |
| AID458141 | Antimicrobial activity against Streptococcus mutans KCTC 3065 at 100 ug/ml after 20 hrs by disk diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | The antimicrobial activity of compounds from the leaf and stem of Vitis amurensis against two oral pathogens. |
| AID1436093 | Inhibition of HFIP-induced human recombinant amyloid beta (1 to 42 residues) aggregation expressed in Escherichia coli measured over 24 hrs by ThT-based fluorescence spectroscopic method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | 2,4-Disubstituted quinazolines as amyloid-β aggregation inhibitors with dual cholinesterase inhibition and antioxidant properties: Development and structure-activity relationship (SAR) studies. |
| AID359189 | Blockade of rat Glut1 expressed in CHO cells assessed as inhibition of 2-[1,2-3H(N)]deoxy-D-glucose uptake by scintillation spectrometry | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3 | Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells. |
| AID359117 | Reversal of induction in ER.DNA complex in mouse MC3T3-E1 cells at 1 uM by RT-PCR in presence of ICI-182780 | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID416677 | Cytotoxicity against human K562 cells after 72 hrs by MTT assay | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Synthesis and biological evaluation of cytotoxic properties of stilbene-based resveratrol analogs. |
| AID759460 | Inhibition of self-mediated amyloid beta (1 to 42) aggregation (unknown origin) after 48 hrs by thioflavin T fluorescence assay | 2013 | Journal of medicinal chemistry, Jul-25, Volume: 56, Issue:14 | Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease. |
| AID359309 | Effect on bone morphogenetic protein receptor 1A gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID642330 | Induction of QR1-mediated cytoprotective activity in mouse Hepa-1c1c7 cells at 50 uM assessed as cell survival | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets. |
| AID1168356 | Hepatoprotective activity against isoniazid-rifampicin induced liver injury in BALB/c mouse assessed as reversal of GSH depletion at 100 mg/kg, po bid for 3 days starting 30 mins prior isoniazid-rifampicin administration measured 24 hrs post-last dose of | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. |
| AID610403 | Metabolic stability in human Caco2 cells after 6 hrs by LC-MS-MS analysis | 2010 | Journal of medicinal chemistry, Oct-28, Volume: 53, Issue:20 | Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents. |
| AID1290886 | Inhibition of Electrophorus electricus acetylcholinesterase using acetylthiocholine iodide substrate after 15 mins by spectrophotometric method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Pterostilbene-O-acetamidoalkylbenzylamines derivatives as novel dual inhibitors of cholinesterase with anti-β-amyloid aggregation and antioxidant properties for the treatment of Alzheimer's disease. |
| AID458145 | Antimicrobial activity against Streptococcus sanguinis NCTC 9811 at 50 ug/ml after 20 hrs by disk diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | The antimicrobial activity of compounds from the leaf and stem of Vitis amurensis against two oral pathogens. |
| AID1571122 | Inhibition of self-induced aggregation of amyloid beta (1 to 42) (unknown origin) after 48 hrs by thioflavin T-based fluorescence method | 2018 | MedChemComm, Nov-01, Volume: 9, Issue:11 | Discovery of boron-containing compounds as Aβ aggregation inhibitors and antioxidants for the treatment of Alzheimer's disease. |
| AID1060589 | Inhibition of amyloid beta (1 to 42) (unknown origin) self-induced aggregation at 20 uM after 46 to 48 hrs by thioflavin-T based fluorometric assay | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Design, synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer's disease. |
| AID1879004 | Inhibition of TGF-beta1 induced apoptosis in C57/B6J mouse primary hepatocytes assessed as early apoptotic cells by Annexin-V-FITC-H and PI staining based flow cytometry analysis (Rvb = 19.89 %) | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID1246395 | Agonist activity at ERalpha (301 to 553 amino acid residues) (unknown origin) assessed as induction of interaction with SRC1 after 24 hrs by yeast two-hybrid assay relative to isopaucifloral F | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Synthesis, estrogenic activity, and anti-osteoporosis effects in ovariectomized rats of resveratrol oligomer derivatives. |
| AID549842 | Agonist activity at estrogen receptor in human Ishikawa cells assessed as increase of estradiol-induced alkaline phosphatase expression at 1 uM after 72 hrs relative to estradiol | 2011 | Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1 | New hydroxystilbenoid derivatives endowed with neuroprotective activity and devoid of interference with estrogen and aryl hydrocarbon receptor-mediated transcription. |
| AID1198742 | Antioxidant activity assessed as DPPH radical scavenging activity incubated for for 5 mins by microplate spectrophotometry | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93 | Antioxidant activity and inhibition of α-glucosidase by hydroxyl-functionalized 2-arylbenzo[b]furans. |
| AID1256170 | Inhibition of Quorum sensing system in Chromobacterium violaceum CV026 assessed as inhibition of violacein synthesis at >100 uM after 18 hrs by spectrophotometric assay | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | The quorum-sensing inhibiting effects of stilbenoids and their potential structure-activity relationship. |
| AID1485919 | Inhibition of HFIP-pretreated amyloid beta (1 to 42) (unknown origin) self-induced aggregation at 20 uM after 46 to 48 hrs by thioflavin-T fluorescence assay relative to control | 2017 | Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14 | Synthesis and pharmacological evaluation of novel chromone derivatives as balanced multifunctional agents against Alzheimer's disease. |
| AID1264952 | Cytotoxicity against human MSC assessed as cell viability at 10 uM measured on day 1 by alamar blue assay (Rvb = 97 to 101%) | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11 | Defining Key Structural Determinants for the Pro-osteogenic Activity of Flavonoids. |
| AID359277 | Reversal of increase in pBMP2 expression in rat primary osteoblast cells at 1 uM by luciferase method in presence of PP2 | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1336832 | Antioxidant activity assessed as fluorescent light-induced superoxide anion scavenging activity at 160 uM incubated for 10 mins by nitroblue tetrazolium dye based assay | 2017 | Bioorganic & medicinal chemistry, 02-01, Volume: 25, Issue:3 | Quinolines: Microwave-assisted synthesis and their antifungal, anticancer and radical scavenger properties. |
| AID402930 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 8 after 24 hrs | 2004 | Journal of natural products, Jun, Volume: 67, Issue:6 | New stilbene derivatives from Calligonum leucocladum. |
| AID1311758 | Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability at 50 umol/L after 24 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata. |
| AID1278610 | Antiinflammatory activity in carrageenan-induced BALB/c mouse peritonitis model assessed as decrease in nitric oxide level in peritoneal exudates at 10 to 20 mg/kg administered via oral gavage 30 mins prior to carrageenan challenge measured after 4 hrs by | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog. |
| AID491527 | Inhibition of aromatase at 34 uM | 2010 | Journal of medicinal chemistry, Jul-08, Volume: 53, Issue:13 | Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. |
| AID432133 | Inhibition of phagocytosis of FITC-conjugated Escherichia coli K12 in mouse RAW264.7 cells using trypan blue staining after 40 mins by flow cytometry | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID1772540 | Neuroprotective activity against PTZ-induced neuronal damage in 5 dpf zebrafish AB larvae assessed as effect on AChE activity at 10 uM pretreated for 1 hr followed by removal of medium and subsequent addition of fresh medium containing PTZ and compounds m | 2021 | European journal of medicinal chemistry, Nov-05, Volume: 223 | Silyl resveratrol derivatives as potential therapeutic agents for neurodegenerative and neurological diseases. |
| AID333439 | Inhibition of peroxidase activity of COX1 in heep seminal vesicle by TMPD assay | 2004 | Journal of natural products, Nov, Volume: 67, Issue:11 | Mechanism-based inactivation of COX-1 by red wine m-hydroquinones: a structure-activity relationship study. |
| AID359101 | Antitumor activity against human MCF7 cells xenografted in SCID mouse orthotropic model assessed as inhibition of 17beta estradiol-induced tumor formation at 10 mg/kg for 2 days | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1632230 | Lipophilicity, log P of the compound | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18 | Synthesis and anticancer activity of a hydroxytolan series. |
| AID378673 | Inhibition of PKC | 2006 | Journal of natural products, Jan, Volume: 69, Issue:1 | A common protein fold topology shared by flavonoid biosynthetic enzymes and therapeutic targets. |
| AID1238826 | Retention time of the compound in C57BL/6J mouse feces treated with RAH at 200 mg/kg, ig by HPLC-CEAD analysis | 2015 | Journal of medicinal chemistry, Aug-27, Volume: 58, Issue:16 | Novel Resveratrol-Based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer Activity. |
| AID1826673 | Permeability of compound in PBS buffer at pH 7.4 by PAMPA-BBB assay | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades. |
| AID620718 | Induction of apoptosis in human HeLa cells assessed as increase in caspase 3 activity at 40 uM after 24 hrs by fluorimetry relative to control | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | Design and synthesis of resveratrol-based nitrovinylstilbenes as antimitotic agents. |
| AID1878986 | Inhibition of TGF-beta1 induced apoptosis in C57/B6J mouse primary hepatocytes assessed as live cells at 25 uM by Annexin-V-FITC-H and PI staining based flow cytometry analysis (Rvb = 66.08 %) | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID1198743 | Antioxidant activity assessed as DPPH radical scavenging activity | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93 | Antioxidant activity and inhibition of α-glucosidase by hydroxyl-functionalized 2-arylbenzo[b]furans. |
| AID1430671 | Cytotoxicity against human SU-DHL10 cells assessed as growth inhibition at 30 uM after 72 hrs by CellTitre-Glo luminescent assay relative to control | 2017 | ACS medicinal chemistry letters, May-11, Volume: 8, Issue:5 | Toward Resolving the Resveratrol Conundrum: Synthesis and |
| AID418724 | Cytotoxicity against human LNCAP cells after 72 hrs by sulforhodamine B assay | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7 | Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. |
| AID1379019 | Antioxidant activity assessed as inhibition of AAPH-induced peroxyl radical generation measured as trolox equivalent preincubated for 15 mins followed by AAPH addition measured every min for 120 mins by ORAC-FL assay | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease. |
| AID299633 | Neuronal differentiation activity assessed as increase in number of neurons at 0.1 uM in relative to 0.5 uM retinoic acid | 2007 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15 | Dual bioactivity of resveratrol fatty alcohols: differentiation of neural stem cells and modulation of neuroinflammation. |
| AID264593 | Proapoptotic activity against human K562 cell line expressing Bcr-Abl | 2006 | Journal of medicinal chemistry, May-18, Volume: 49, Issue:10 | Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. |
| AID359540 | Effect on tumor necrosis factor gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1611934 | Inhibition of tyrosinase (unknown origin) | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17 | Inhibitors of Melanogenesis: An Updated Review. |
| AID481124 | Displacement of FITC-conjugated BH3-Bak peptide from Vaccinia virus recombinant N1L expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assay | 2010 | Journal of medicinal chemistry, May-27, Volume: 53, Issue:10 | Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention. |
| AID1652958 | Oral bioavailability in human | 2019 | European journal of medicinal chemistry, Jan-01, Volume: 161 | An overview of Sirtuins as potential therapeutic target: Structure, function and modulators. |
| AID1264949 | Cytotoxicity against human MSC assessed as decrease in cell number at 1 to 10 uM after 9 days by methylene blue staining based microscopy relative to control | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11 | Defining Key Structural Determinants for the Pro-osteogenic Activity of Flavonoids. |
| AID1365632 | Selectivity index, ratio of IC50 for human MAO-A to IC50 for human MAO-B | 2017 | Bioorganic & medicinal chemistry, 11-01, Volume: 25, Issue:21 | Design, synthesis, and evaluation of salicyladimine derivatives as multitarget-directed ligands against Alzheimer's disease. |
| AID713100 | Inhibition of mushroom tyrosinase-mediated oxygen consumption using L-DOPA substrate at 100 uM after 30 mins | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID1298438 | Potentiation of 5-Aza-C-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as Nef mutation at 50 uM incubated for 4 hrs preinfection followed by 5-Aza-C addition for 2 hrs preinfection and subsequen | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID294468 | ABTS radical scavenging activity assessed as trolox equivalent antioxidant capacity | 2007 | European journal of medicinal chemistry, Jun, Volume: 42, Issue:6 | Quinone reductase induction activity of methoxylated analogues of resveratrol. |
| AID359549 | Effect on peptidylprolyl isomerase A gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID474868 | Antioxidant activity assessed as galvinoxyl radical scavenging activity in ethyl acetate by UV-visible spectroscopy | 2010 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8 | Antioxidant and antiproliferative activities of hydroxyl-substituted Schiff bases. |
| AID333441 | Inactivation of holo-COX1 in sheep seminal vesicle assessed as drug oxidization at 23.5 nmol by RP-HPLC in presence of hydrogen peroxide | 2004 | Journal of natural products, Nov, Volume: 67, Issue:11 | Mechanism-based inactivation of COX-1 by red wine m-hydroquinones: a structure-activity relationship study. |
| AID674915 | Antioxidant activity assessed as DPPH scavenging activity after 30 mins by microplate reader method | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17 | The antioxidant effect of imine resveratrol analogues. |
| AID1225530 | Reduction in Bcl-xL expression in prostate tissue in BPH-induced Sprague-Dawley rat model at 1 mg/kg, ip daily for 4 weeks by Western blot analysis | 2015 | Journal of natural products, Apr-24, Volume: 78, Issue:4 | Effects of resveratrol on benign prostatic hyperplasia by the regulation of inflammatory and apoptotic proteins. |
| AID491530 | Cell cycle arrest in human HL60 cells assessed as accumulation at sub-G1 phase at 34 uM after 24 hrs by flow cytometry | 2010 | Journal of medicinal chemistry, Jul-08, Volume: 53, Issue:13 | Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. |
| AID1362760 | Inhibition of IL-6 production in ear tissue of croton oil-induced Balb/c mouse ear edema model at 0.1 mg/ear administered topically immediately post croton oil treatment by ELISA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues. |
| AID549849 | Displacement of fluorescent estrogen ES2 from human recombinant ERalpha by fluorescence polarization assay relative to estradiol | 2011 | Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1 | New hydroxystilbenoid derivatives endowed with neuroprotective activity and devoid of interference with estrogen and aryl hydrocarbon receptor-mediated transcription. |
| AID1486519 | Binding affinity to transthyretin in human blood plasma assessed as plasma binding selectivity by measuring stoichiometry of small molecule bound to TTR incubated for 24 hrs at 37 degC by RP-HPLC | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors. |
| AID1278608 | Antiinflammatory activity in carrageenan-induced BALB/c mouse peritonitis model assessed as decrease in number of leukocytes in peritoneal exudates at 10 to 20 mg/kg administered via oral gavage 30 mins prior to carrageenan challenge measured after 4 hrs | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog. |
| AID1372026 | Antioxidant activity assessed as relative scavenging rate constant for photolysis-induced methyl radical scavenging activity by measuring Kaox/Kst ratio using DMPO spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID491614 | Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW 264.7 cells at 34 uM pretreated 30 mins before LPS challenge measured after 20 hrs by Griess reaction method relative to control | 2010 | Journal of medicinal chemistry, Jul-08, Volume: 53, Issue:13 | Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. |
| AID655179 | Cell cycle arrest in human HepG2 cells assessed as accumulation at subG0 phase at 50 uM after 24 hrs by FACS analysis relative to control | 2012 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5 | A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. |
| AID1298408 | Potentiation of 5-Aza-dC-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as increase in total mutation frequency at 50 uM incubated for 4 hrs preinfection followed by 5-Aza-C addition for 2 hrs p | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1311780 | Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as COX2 levels at 25 umol/L by ELISA (Rvb = 159.64 +/- 13.56 pg/mL) | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata. |
| AID716916 | Cytotoxicity against mouse B16F10 cells assessed as suppression of cell viability at 12.5 to 200 uM after 72 hrs | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID1872730 | Inhibition of Amyloid beta (1 to 42) (unknown origin) self aggregation at 25 uM incubated for 24 hrs by ThT-based fluorescence assay relative to control | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy. |
| AID1225527 | Reduction in procaspase 3 expression in prostate tissue in BPH-induced Sprague-Dawley rat model at 1 mg/kg, ip daily for 4 weeks by Western blot analysis | 2015 | Journal of natural products, Apr-24, Volume: 78, Issue:4 | Effects of resveratrol on benign prostatic hyperplasia by the regulation of inflammatory and apoptotic proteins. |
| AID1418631 | Disaggregation of self-induced amyloid beta (1 to 42) (unknown origin) preformed fibrils at 50 uM after 24 hrs by uranyl acetate staining based transmission electron microscopic analysis | 2018 | Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22 | Resveratrol-maltol hybrids as multi-target-directed agents for Alzheimer's disease. |
| AID614088 | Antifungal activity against Botrytis cinerea FSU 883 at 10 mg/ml after 24 to 72 hrs by agar diffusion method | 2011 | Bioorganic & medicinal chemistry, Sep-01, Volume: 19, Issue:17 | Synthesis and antimicrobial activity of (E) stilbene derivatives. |
| AID1336833 | Antioxidant activity assessed as fluorescent light-induced superoxide anion scavenging activity incubated for 10 mins by nitroblue tetrazolium dye based assay | 2017 | Bioorganic & medicinal chemistry, 02-01, Volume: 25, Issue:3 | Quinolines: Microwave-assisted synthesis and their antifungal, anticancer and radical scavenger properties. |
| AID724575 | Binding affinity to planer lipid bilayer assessed as change in height of semicircle pattern by admittance spectroscopic analysis | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Dose-dependent interaction of trans-resveratrol with biomembranes: effects on antioxidant property. |
| AID336034 | Inhibition of bovine thymus p56LCK | 1993 | Journal of natural products, Oct, Volume: 56, Issue:10 | Kinase inhibitors from Polygonum cuspidatum. |
| AID402927 | DPPH radical scavenging activity assessed as ratio of absorbance at 20 uM relative to L-cysteine | 2004 | Journal of natural products, Jun, Volume: 67, Issue:6 | New stilbene derivatives from Calligonum leucocladum. |
| AID1371376 | Cytotoxicity against human MML1 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1311767 | Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as PGE2 levels at 25 umol/L by ELISA (Rvb = 33.2 +/- 2.33 pg/mL) | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata. |
| AID738205 | Cytotoxicity against human KB cells assessed as growth inhibition measured at 100 uM after 48 hrs by XTT assay | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID273484 | Antioxidant activity measured as ability to react with ABTS radical cation at 15 uM by TRAP assay | 2006 | Journal of medicinal chemistry, Nov-30, Volume: 49, Issue:24 | Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB. |
| AID1309180 | Inhibition of preformed Cu2+-induced amyloid beta (1 to 40) fibril aggregation assessed as remaining fibril aggregates at 100 uM after 4 days at pH 6.60 by thioflavin-T fluorescence assay | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Ionophoric polyphenols selectively bind Cu(2+), display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila. |
| AID468423 | Cmax in intragastrically dosed rat at 0.09 mmol/kg after 10 mins | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | Soluble polyphenols: synthesis and bioavailability of 3,4',5-tri(alpha-D-glucose-3-O-succinyl) resveratrol. |
| AID1298364 | Antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as reduction in gag level at 50 uM measured at 6 hrs post infection by qPCR method | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID735499 | Ratio of EC50 for SIRT1 R446A mutant (unknown origin) to EC50 for wild type SIRT1 (unknown origin) | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate. |
| AID655177 | Cell cycle arrest in human HepG2 cells assessed as accumulation at S phase at 50 uM after 24 hrs by FACS analysis (Rvb = 29.5 %) | 2012 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5 | A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. |
| AID713099 | Inhibition of mushroom tyrosinase assessed as L-DOPA oxidation HPLC analysis | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID1264947 | Induction of osteogenic differentiation in human MSC assessed as increase in ALP activity at 10 uM using p-NPP as substrate after 9 days by colorimetric method relative to control | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11 | Defining Key Structural Determinants for the Pro-osteogenic Activity of Flavonoids. |
| AID692942 | Cytotoxicity against human HCT116 cells at 10 uM for 4 days by vi-cell cell viability analysis | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID1309168 | Binding affinity to amyloid beta (1 to 40) (unknown origin) by tyrosine fluorimetric titration assay | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Ionophoric polyphenols selectively bind Cu(2+), display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila. |
| AID1632200 | Cytotoxicity against human MDAH 2774 cells after 48 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18 | Synthesis and anticancer activity of a hydroxytolan series. |
| AID640884 | Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins by microplate reader assay | 2012 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 22, Issue:2 | Antioxidative oligostilbenes from Caragana sinica. |
| AID637955 | Antibacterial activity against CagA-deficient Helicobacter pylori Ba142 isolated from chronic gastritis patient after 48 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1256176 | Inhibition of Quorum sensing system in Pseudomonas aeruginosa PAO1 assessed as inhibition of pyocyanin production at 400 uM after 16 to 18 hrs by spectrophotometric assay | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | The quorum-sensing inhibiting effects of stilbenoids and their potential structure-activity relationship. |
| AID1203643 | Cell cycle arrest in human Bel7402 cells assessed as cells accumulation at S phase at 50 uM after 48 hrs by flow cytometry (Rvb = 13.99%) | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Design, synthesis, and biological evaluation of benzoselenazole-stilbene hybrids as multi-target-directed anti-cancer agents. |
| AID1452013 | Competitive binding affinity to human wild type TTR expressed in Escherichia coli BL-21 assessed as equilibrium dissociation constant of second site in presence of ANS by spectrofluorometer | 2017 | Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18 | Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation. |
| AID332219 | Inhibition of DMBA-induced preneoplastic lesions in mouse mammary gland organ culture at 10 ug/mL | 2002 | Journal of natural products, Feb, Volume: 65, Issue:2 | Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity. |
| AID1362741 | Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability at 50 uM after 48 hrs by MTT assay | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues. |
| AID1879029 | Antifibrotic activity in CCL-4 induced liver fibrosis C57/B6J mouse model transfected with miR-190a-5p agomir assessed as increase in albumin level in serum at 100 mg/kg/day, ip measured after 72 hrs post last dose by ELISA | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID1534713 | Selectivity ratio of IC50 for human MAO-A to IC50 for human MAO-B | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease. |
| AID501909 | Inhibition of human carbonic anhydrase 6 after 15 mins by stopped flow CO2 hydration method | 2010 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17 | Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. |
| AID738213 | Cytotoxicity against human HL60 cells assessed as growth inhibition measured after 48 hrs by XTT assay | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID359079 | Increase in osteocalcin mRNA levels in mouse MC3T3-E1 cells at 1 uM after 72 hrs by RT-PCR | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID697065 | Inhibition of duck liver FASN ketoreductase activity | 2011 | Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16 | The lipogenesis pathway as a cancer target. |
| AID738184 | Inhibition of Ets signaling pathway in human HeLa cells assessed as inhibition of PMA induced luciferase treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID1570232 | Antioxidant activity in rat H9c2 cells assessed as increase in hypoxia-induced reduction of MnSOD expression at 2 uM preincubated for 18 hrs followed by incubated in hypoxia for 48 hrs by Western blot analysis | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors. |
| AID1879030 | Antifibrotic activity in CCL-4 induced liver fibrosis C57/B6J mouse model assessed as increase in bilirubin level in serum at 100 mg/kg/day, ip measured after 72 hrs post last dose by ELISA | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID1081912 | Antifungal activity against Botryotinia fuckeliana assessed as growth inhibition after 48 hr by NCCLS M27-A broth microdilution method | 2011 | Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5 | Biological activity of peanut (Arachis hypogaea) phytoalexins and selected natural and synthetic Stilbenoids. |
| AID1362746 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced CCL-2 production by measuring CCL-2 levels incubated with LPS for 1 hr followed by compound addition measured after 48 hrs by ELISA (Rvb = 12.73 +/- 0.10 ng/ml) | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues. |
| AID1570230 | Antioxidant activity in rat H9c2 cells assessed as reduction in hypoxia-induced NO release at 80 nM to 2 uM preincubated for 18 hrs followed by incubated in hypoxia for 48 hrs by griess assay | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors. |
| AID432162 | Inhibition of FSL1-induced upregulation of dectin-1 mRNA expression in in human THP1 cells at 100 uM after 1 hr by RT-PCR | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID416708 | Antimitotic activity in Lytechinus variegatus embryo assessed as inhibition of blastula formation at 43.8 uM relative to control | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Synthesis and biological evaluation of cytotoxic properties of stilbene-based resveratrol analogs. |
| AID331047 | Activation of human SIRT1-A (156-664) construct by mass spectrometry assay relative to control | 2007 | Nature, Nov-29, Volume: 450, Issue:7170 | Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. |
| AID289278 | Inhibition of ovine COX1 by measuring PGE2 | 2007 | Bioorganic & medicinal chemistry, Sep-15, Volume: 15, Issue:18 | 'Bridged' stilbene derivatives as selective cyclooxygenase-1 inhibitors. |
| AID359111 | Increase in serum BMP2 levels in orally dosed ovariectomized Wistar rat after 10 weeks by ELISA relative to sham operated control | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1083162 | Antifungal activity against Neofusicoccum parvum Bp0014 assessed as growth inhibition measured after 1 to 10 days | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID1608173 | Binding affinity to Keap1 in rat HBZY-1 cells assessed as induction of Keap1/Nrf2 signaling by measuring increase in HO-1 mRNA expression at 6 uM by RT-PCR analysis | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Synthesis and assessment of phenylacrylamide derivatives as potential anti-oxidant and anti-inflammatory agents. |
| AID359313 | Effect on procollagen 9 alpha 3 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1203635 | Antiproliferative activity against human HeLa cells assessed as cell viability after 48 hrs by MTT assay | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Design, synthesis, and biological evaluation of benzoselenazole-stilbene hybrids as multi-target-directed anti-cancer agents. |
| AID271283 | Inhibition of COX1 assessed as TBX2 production in human whole blood | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17 | Selective COX-2 inhibitors. Part 1: synthesis and biological evaluation of phenylazobenzenesulfonamides. |
| AID1428599 | Inhibition of HFIP-pretreated amyloid beta (1 to 42) (unknown origin) self-induced aggregation incubated for 24 hrs under dark condition by thioflavin-T based fluorometric assay | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Synthesis and biological evaluation of deferiprone-resveratrol hybrids as antioxidants, Aβ |
| AID1534714 | Antioxidant activity assessed as inhibition of DPPH free radical after 30 mins by UV-Visible spectrophotometric analysis | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease. |
| AID1884078 | Bactericidal activity against Enterococcus faecalis V583 at 128 uM measured upto 24 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID1611504 | Thermal stability of compound in DMSO/methanol assessed as onset temperature by UV spectroscopic method | 2019 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 29, Issue:24 | Synthesis and evaluation of 1,3,5-triazine derivatives as sunscreens useful to prevent skin cancer. |
| AID430025 | Antiproliferative activity against P-gp expressing human DLKP-A cells assessed as cell proliferation at 10 uM after 5 days by acid phosphatase assay | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13 | Synthesis, structural characterisation and biological evaluation of fluorinated analogues of resveratrol. |
| AID620728 | Antiproliferative activity against human A549 cells assessed as cell viability after 48 hrs by SRB assay | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | Design and synthesis of resveratrol-based nitrovinylstilbenes as antimitotic agents. |
| AID1178156 | Antioxidant activity of the compound assessed as reduction in absorbance of DPPH after 60 mins incubation at 1000 uM by DPPH radical scavenging /microplate assay | 2014 | Bioorganic & medicinal chemistry, May-01, Volume: 22, Issue:9 | Synthesis, antioxidant and photoprotection activities of hybrid derivatives useful to prevent skin cancer. |
| AID1894199 | Inhibition of amyloid beta 42 (unknown origin) at 20 uM relative to control | 2021 | European journal of medicinal chemistry, Mar-15, Volume: 214 | Amyloid-β and tau aggregation dual-inhibitors: A synthetic and structure-activity relationship focused review. |
| AID491525 | Antioxidant activity assessed as DPPH scavenging activity at 340 uM after 30 mins | 2010 | Journal of medicinal chemistry, Jul-08, Volume: 53, Issue:13 | Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. |
| AID1225520 | Reduction in serum dihydrotestosterone in BPH-induced Sprague-Dawley rat model at 1 mg/kg, ip daily for 4 weeks by ELISA | 2015 | Journal of natural products, Apr-24, Volume: 78, Issue:4 | Effects of resveratrol on benign prostatic hyperplasia by the regulation of inflammatory and apoptotic proteins. |
| AID692953 | Inhibition of Wnt/beta-casein in human LS174T cells assessed as reduction in c-Myc protein level at 100 uM by Western blotting | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID455031 | Cytotoxicity against human BxPC3 cells after 48 hrs by sulforhodamine B assay | 2009 | Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18 | E-Combretastatin and E-resveratrol structural modifications: antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes. |
| AID598204 | Inhibition of amyloid beta (1 to 40) fibril formation at 5 uM by UV-visible spectrometry analysis | 2011 | Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10 | Protective effect of ε-viniferin on β-amyloid peptide aggregation investigated by electrospray ionization mass spectrometry. |
| AID1399532 | Inhibition of recombinant full length tau 0N4R (unknown origin) aggregation expressed in Escherichia coli at 20 uM after 72 hrs by thioflavin S assay relative to control | 2018 | Bioorganic & medicinal chemistry, 09-01, Volume: 26, Issue:16 | Synthesis and evaluation of 1,2,3,4-tetrahydro-1-acridone analogues as potential dual inhibitors for amyloid-beta and tau aggregation. |
| AID634527 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite production after 24 hrs by Griess method | 2011 | Bioorganic & medicinal chemistry, Dec-15, Volume: 19, Issue:24 | Synthesis and study of new paramagnetic resveratrol analogues. |
| AID655204 | Inhibition of human FHCC-98 cell adhesion to matrigel-coated plates at 50 uM after 30 to 60 mins by crystal violet staining-based spectrophotometry | 2012 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5 | A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. |
| AID1430692 | Drug metabolism in human hepatocytes assessed as resveratrol-glucuronide formation at 5 uM by LC-MS/MS analysis | 2017 | ACS medicinal chemistry letters, May-11, Volume: 8, Issue:5 | Toward Resolving the Resveratrol Conundrum: Synthesis and |
| AID638151 | Bactericidal activity against CagA-deficient Helicobacter pylori G204 isolated from chronic gastritis patient compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID359315 | Effect on procollagen 4 alpha 2 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1178162 | In vitro photoprotection of the compound assessed as UVA protection factor by Optometric 290S analyzer | 2014 | Bioorganic & medicinal chemistry, May-01, Volume: 22, Issue:9 | Synthesis, antioxidant and photoprotection activities of hybrid derivatives useful to prevent skin cancer. |
| AID641064 | Antihyperglycemic activity in ddY mouse assessed as inhibition of sucrose-induced increase in plasma glucose level at 200 mg/kg, po administered 30 mins before sucrose challenge measured after 0.5 hrs (Rvb = 220.5 +/- 16.9 mg/dl) | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Antidiabetogenic oligostilbenoids and 3-ethyl-4-phenyl-3,4-dihydroisocoumarins from the bark of Shorea roxburghii. |
| AID1609865 | Inhibition of recombinant human N-terminal His-tagged SGK1 at 50 uM using (GRPRTSSFAEGKK) peptide as substrate incubated for 30 mins in presence of [32P] gamma ATP by scintillation counter method | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Review about the multi-target profile of resveratrol and its implication in the SGK1 inhibition. |
| AID359099 | Reduction in anchorage-independent colony formation of human MCF7 cells at 1 uM by soft agar colony forming assay | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID370919 | Inhibition of COX1 | 2009 | Bioorganic & medicinal chemistry, Feb-01, Volume: 17, Issue:3 | Synthesis and biological evaluation of a library of resveratrol analogues as inhibitors of COX-1, COX-2 and NF-kappaB. |
| AID642343 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 30 mins before LPS challenge measured after 24 hrs by Griess method | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets. |
| AID409730 | Inhibition of PTP1B | 2008 | Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18 | Derivatives of 1,4-bis(3-hydroxycarbonyl-4-hydroxyl)styrylbenzene as PTP1B inhibitors with hypoglycemic activity. |
| AID359092 | Increase in serum ALP activity in ovariectomized Wistar rat dosed orally after 10 weeks | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1406253 | Inhibition of human BChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured for 1 min by Ellman's assay | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities. |
| AID1168355 | Hepatoprotective activity against isoniazid-rifampicin induced liver injury in BALB/c mouse assessed as reduction ALT level at 100 mg/kg, po bid for 3 days starting 30 mins prior isoniazid-rifampicin administration measured 24 hrs post-last dose of isonia | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. |
| AID1573648 | Activation of Nrf2 in rat HBZY-1 cells assessed as increase in HO-1 level at 6 uM by Western blot analysis | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and biological evaluation of bifendate derivatives bearing acrylamide moiety as novel antioxidant agents. |
| AID1884094 | Antibacterial activity against Bacillus cereus ATCC 10987 assessed as intracellular ATP levels at 32 uM measured upto 120 min by BacTiter-Glo luminescent cell viability assay | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID474870 | Growth inhibition of human HepG2 cells after 72 hrs by sulforhodamine B assay | 2010 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8 | Antioxidant and antiproliferative activities of hydroxyl-substituted Schiff bases. |
| AID1333804 | Cell cycle arrest in human HeLa cells assessed as accumulation at G2/M phase at 50 uM after 24 hrs by propidium iodide-based FACS analysis (Rvb = 7.12%) | 2017 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1 | Synthesis and bioactivity evaluation of 2,3-diaryl acrylonitrile derivatives as potential anticancer agents. |
| AID1326306 | Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24 | Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ. |
| AID1168376 | Hepatoprotective activity against isoniazid-rifampicin induced liver injury in BALB/c mouse assessed as effect on NADH concentration at 100 mg/kg, po bid for 3 days starting 30 mins prior isoniazid-rifampicin administration measured 24 hrs post-last dose | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. |
| AID1362659 | Toxicity in Tetrahymena thermophila assessed as decrease in viability after 48 hrs by MTT assay | |||
| AID1278612 | Antiinflammatory activity in carrageenan-induced BALB/c mouse paw edema model assessed as decrease in paw volume administered orally 30 mins prior to carrageenan challenge measured after 1 to 6 hrs by plethysmometric analysis | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog. |
| AID1440193 | Activation of human C-terminal His6-tagged SIRT1 expressed in Escherichia coli BL21(DE3) assessed as increase in deacetylated peptide substrate level using p53-derived substrate incubated for 25 mins in presence of NAD+ by mass spectrometric method | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Design, synthesis of allosteric peptide activator for human SIRT1 and its biological evaluation in cellular model of Alzheimer's disease. |
| AID1298441 | Potentiation of 5-Aza-dC-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as Vif mutation at 50 uM incubated for 4 hrs preinfection followed by 5-Aza-C addition for 2 hrs preinfection and subseque | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1519071 | Cytotoxicity against C57BL/6 mouse B16F10 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay relative to control | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | From bench to counter: Discovery and validation of a peony extract as tyrosinase inhibiting cosmeceutical. |
| AID359124 | Reversal of increase in ER.DNA complex in mouse MC3T3-E1 cells at 1 uM by RT-PCR in presence of PP2 | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID608254 | Antibacterial activity against 1 x 10'4 cfu/mL Staphylococcus aureus ATCC 29213 after 24 hrs by NCCLS M7-A6 microtiter broth dilution method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis and antimicrobial evaluation of new benzofuran derivatives. |
| AID1311769 | Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as NO levels at 5 umol/L by ELISA (Rvb = 0.95 +/- 0.052 umol/mL) | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata. |
| AID1825236 | Activation of SIRT1 (unknown origin) expressed in human HEK293 cells assessed as increase in NAD+/NADH ratio at 10 to 40 uM in presence of NAD+ as substrate incubated for 12 hrs by NAD+/NADH assay based fluorescence microplate reader | |||
| AID1872722 | Inhibition of HFIP-treated Amyloid beta (1 to 42) (unknown origin) self aggregation incubated for 46 to 48 hrs by fluorescence based assay | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy. |
| AID1611503 | Antioxidant activity assessed as DPPH free radical scavenging activity at 100 uM incubated for 60 mins by spectrophotometric method relative to control | 2019 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 29, Issue:24 | Synthesis and evaluation of 1,3,5-triazine derivatives as sunscreens useful to prevent skin cancer. |
| AID1608147 | Binding affinity to Keap1 in rat HBZY-1 cells assessed as induction of Keap1/Nrf2 signaling by measuring increase in GCLM protein expression by Western blot analysis | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Synthesis and assessment of phenylacrylamide derivatives as potential anti-oxidant and anti-inflammatory agents. |
| AID207127 | The minimum inhibitory concentration (MIC) that inhibits all visible growth of the Stenotrophomonas maltophilia (bacteria) at 64 ug/ml | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID1570228 | Cytoprotective activity against hypoxia-induced toxicity rat H9c2 cells assessed as increase in cell viability at 20 uM preincubated for 18 hrs followed by incubated in hypoxia for 48 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors. |
| AID724380 | Antioxidant activity in planer lipid bilayer membrane assessed as inhibition of DPPH-induced reduction in diameter of semicircle at 50 to 100 uM by admittance spectroscopic analysis | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Dose-dependent interaction of trans-resveratrol with biomembranes: effects on antioxidant property. |
| AID289282 | Relaxing effect on guinea pig aorta ring assessed as reduction of force of contraction at 100 uM | 2007 | Bioorganic & medicinal chemistry, Sep-15, Volume: 15, Issue:18 | 'Bridged' stilbene derivatives as selective cyclooxygenase-1 inhibitors. |
| AID1718916 | Selectivity ratio of IC50 for human hFOB1.19 cells to IC50 for human MG-63 cells | 2020 | Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24 | Cancer Stem Cell (CSC) Inhibitors in Oncology-A Promise for a Better Therapeutic Outcome: State of the Art and Future Perspectives. |
| AID337730 | Effect on Agrobacterium tumefaciens-induced crown gall tumor in potato tubers by potato disk assay relative to control | |||
| AID359537 | Effect on transforming growth factor beta receptor 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID501905 | Inhibition of human carbonic anhydrase 3 after 15 mins by stopped flow CO2 hydration method | 2010 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17 | Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. |
| AID479979 | Inhibition of human recombinant NQO2 assessed as reduction of DCPIP by spectrophotometry | 2010 | Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9 | Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. |
| AID359526 | Effect on matrix metalloprotease 9 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID359088 | Increase in osteopontin levels in mouse MC3T3-E1 cells at 1 uM after 72 hrs by ELISA | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1264957 | Cytotoxicity against human MSC assessed as cell viability at 5 uM treated for 6 days measured on day 7 by alamar blue assay (Rvb = 96 to 101%) | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11 | Defining Key Structural Determinants for the Pro-osteogenic Activity of Flavonoids. |
| AID1573653 | Activation of Nrf2 in rat HBZY-1 cells assessed as increase in GCLM mRNA expression at 6 uM after 24 hrs by RT-PCR analysis | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and biological evaluation of bifendate derivatives bearing acrylamide moiety as novel antioxidant agents. |
| AID1826675 | Neuroprotective activity against okadaic acid induced toxicity in rat primary cortical neurons cells assessed as reduction in cell viability at 1 uM by MTT assay | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades. |
| AID458151 | Antimicrobial activity against Streptococcus sanguinis NCTC 9811 after 20 hrs by plate dilution method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | The antimicrobial activity of compounds from the leaf and stem of Vitis amurensis against two oral pathogens. |
| AID150946 | In vitro inhibition of P388 (murine leukemia) cell proliferation. | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID359523 | Effect on matrix metalloprotease 13 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID264591 | Proapoptotic activity against MDR human HL60R cell line | 2006 | Journal of medicinal chemistry, May-18, Volume: 49, Issue:10 | Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. |
| AID725752 | Cytotoxicity against human MDA-MB-231 cells by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 23, Issue:3 | Novel Aza-resveratrol analogs: synthesis, characterization and anticancer activity against breast cancer cell lines. |
| AID1826674 | Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 100 uM incubated for 24 hrs by MTT assay | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades. |
| AID1872743 | Antioxidant activity assessed as ABTS radical scavenging activity measured after 6 mins | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy. |
| AID719267 | Inhibition of LPS-induced iNOS activity in mouse RAW 264.7 cells assessed as inhibition of NO production pretreated with compound for 30 mins before LPS challenge after 24 hrs by Griess reagent method | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1). |
| AID521220 | Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay | 2007 | Nature chemical biology, May, Volume: 3, Issue:5 | Chemical genetics reveals a complex functional ground state of neural stem cells. |
| AID595052 | Antiproliferative activity against human A549 cells after 48 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry, Apr-15, Volume: 19, Issue:8 | Synthesis, biological evaluation, and molecular docking studies of resveratrol derivatives possessing chalcone moiety as potential antitubulin agents. |
| AID1314122 | Radioprotective activity in rat thymocytes assessed as radio-modification factor pretreated at 10 uM followed by 2 Gy X-ray irradiation measured after 4 hrs by flow cytometric analysis relative to control | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | A facile and rapid access to resveratrol derivatives and their radioprotective activity. |
| AID642091 | Inhibition of human aromatase using dibenzylfluorescein as substrate preincubated for 30 mins measured after 2 hrs by fluorimetry | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets. |
| AID638062 | Bactericidal activity against CagA-deficient Helicobacter pylori G104 isolated from chronic gastritis patient compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1298266 | Potentiation of 5-Aza-C-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as decrease in 5-Aza-C EC50 at 50 uM preincubated for 2 hrs followed by 5-Aza-C addition for 2 hrs and subsequent viral inf | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1407181 | Antioxidant activity assessed as DPPH radical scavenging activity measured after 30 mins incubation in dark by UV-Visible spectrophotometric analysis | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties. |
| AID1616106 | Inhibition of ATP synthase in Escherichia coli relative to control | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Recent advancements in mechanistic studies and structure activity relationship of F |
| AID1168377 | Hepatoprotective activity against isoniazid-rifampicin induced liver injury in BALB/c mouse assessed as reduction in TNFalpha level at 100 mg/kg, po bid for 3 days starting 30 mins prior isoniazid-rifampicin administration measured 24 hrs post-last dose o | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. |
| AID1391154 | Antimalarial activity against Plasmodium falciparum 3D7 asexual cultures grown under 5% haematocrit assessed as decrease in parasite DNA level by flow cytometry | 2018 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 28, Issue:8 | Evaluation of analogues of furan-amidines as inhibitors of NQO2. |
| AID1872721 | Inhibition of human recombinant MAO-B incubated for 15 mins by Amplex red MAO assay | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy. |
| AID1278618 | Antioxidant activity assessed as DPPH free radical scavenging activity at 0.06 to 200 uM after 30 mins by spectrophotometric analysis | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog. |
| AID1362759 | Inhibition of myeloperoxidase activity in ear tissue of croton oil-induced Balb/c mouse ear edema model at 0.1 mg/ear administered topically immediately post croton oil treatment by spectrophotometric method | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues. |
| AID478952 | Antiproliferative activity against human H460 cells after 72 hrs | 2010 | Bioorganic & medicinal chemistry, May-15, Volume: 18, Issue:10 | Design, synthesis and anticancer activities of stilbene-coumarin hybrid compounds: Identification of novel proapoptotic agents. |
| AID749800 | Antiangiogenic activity against BAEC assessed as inhibition of tube formation after 7 hrs by matrigel assay | 2013 | Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11 | Inhibition of VEGF expression in cancer cells and endothelial cell differentiation by synthetic stilbene derivatives. |
| AID166395 | Inhibitory effect on PGE-2 production in LPS-stimulated RAW264.7 cells | 2004 | Bioorganic & medicinal chemistry letters, May-03, Volume: 14, Issue:9 | Styrylheterocycles as a novel class inhibitor of cyclooxygenase-2-mediated prostaglandin E(2) production. |
| AID724572 | Induction of blebbing morphology in human erythrocytes up to 100 uM after 1 hr by cold field emission scanning electron microscopic analysis | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Dose-dependent interaction of trans-resveratrol with biomembranes: effects on antioxidant property. |
| AID1311777 | Inhibition of NFkappaB signaling pathway in LPS-stimulated mouse RAW264.7 cells assessed as protein levels at 50umol/L by ELISA (Rvb = 1.23 +/- 0.06 pg/mL) | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata. |
| AID1362646 | Inhibition of self-induced amyloid beta (1 to 40) (unknown origin) fibril aggregation assessed as fluorescence emission at 100 uM measured on day 7 by thioflavin-T based assay (Rvb = 391.27 +/- 8.68 No_unit) | |||
| AID638155 | Bactericidal activity against CagA-expressing Helicobacter pylori 328 isolated from chronic gastritis patient compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1854423 | Inhibition of recombinant LSD1 (unknown origin) incubated for 1 hr | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | A comprehensive comparative study on LSD1 in different cancers and tumor specific LSD1 inhibitors. |
| AID1570229 | Cytoprotective activity against hypoxia-induced toxicity rat H9c2 cells assessed as increase in cell viability at 20 uM incubated for 18 hrs in hypoxia measured after 48 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors. |
| AID1608148 | Binding affinity to Keap1 in rat HBZY-1 cells assessed as induction of Keap1/Nrf2 signaling by measuring increase in GCLC protein expression by Western blot analysis | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Synthesis and assessment of phenylacrylamide derivatives as potential anti-oxidant and anti-inflammatory agents. |
| AID82976 | In vitro concentration required to induce apoptosis in HL60 cells | 2003 | Journal of medicinal chemistry, Jul-31, Volume: 46, Issue:16 | Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents. |
| AID1278604 | Antiinflammatory activity in BALB/c mouse paw edema model assessed as decrease in myeloperoxidase activity in paw exudates at 20 mg/kg, po administered 30 mins prior to carrageenan challenge measured after 4 hrs by microplate reader analysis relative to c | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog. |
| AID1314123 | Radioprotective activity in rat thymocytes assessed as radio-modification factor pretreated at 100 uM followed by 2 Gy X-ray irradiation measured after 4 hrs by flow cytometric analysis relative to control | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | A facile and rapid access to resveratrol derivatives and their radioprotective activity. |
| AID1333786 | Selectivity index, ratio of IC50 for human L02 cells to IC50 for human HCT116 cells | 2017 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1 | Synthesis and bioactivity evaluation of 2,3-diaryl acrylonitrile derivatives as potential anticancer agents. |
| AID359074 | Antiproliferative activity against human MCF7 cells at 1 uM by flow cytometry | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID432145 | Inhibition of FSL-1-induced increase in phagocytosis of FITC-conjugated Staphylococcus aureus 209P in mouse RAW264.7 cells using trypan blue staining after 20 mins by flow cytometry | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID1352508 | Neuroprotective activity in 3-NP intoxicated C57BL/6 mouse model assessed as increase in SOD2 expression at 5.5 mg/kg, ip administered for 5 days by qRT-PCR analysis | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Alkylated resveratrol prodrugs and metabolites as potential therapeutics for neurodegenerative diseases. |
| AID682967 | Inhibition of adipogenesis in mouse 3T3L1 cells assessed as fat accumulation at 100 uM after 8 days by oil red O-staining based by ELISA plate reader | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 | Anti-adipogenic chromone glycosides from Cnidium monnieri fruits in 3T3-L1 cells. |
| AID639322 | Antibacterial activity against CagA-expressing Helicobacter pylori G27 isolated from chronic gastritis patient after 24 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID359089 | Increase in osteopontin levels in human MG63 cells at 1 uM after 72 hrs by ELISA | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID762883 | Induction of SIRT1-mediated NRF-1 expression in H2O2-induced HUVEC pretreated for 1 day followed by compound washout and H2O2-treatment measured after 10 days by RT-PCR analysis | 2013 | Journal of natural products, Jul-26, Volume: 76, Issue:7 | trans-Resveratrol in Gnetum gnemon protects against oxidative-stress-induced endothelial senescence. |
| AID1717735 | Inhibition of human tyrosinase expressed in HEK293 cells | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Advances in the Design of Genuine Human Tyrosinase Inhibitors for Targeting Melanogenesis and Related Pigmentations. |
| AID638055 | Antibacterial activity against CagA-expressing Helicobacter pylori 18C7 isolated from gastric carcinoma patient after 48 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1362632 | Inhibition of BACE 1 (unknown origin) at 10 to 50 uM using Rh-EVNLDAEFK-Quencher as substrate after 1 hr by FRET assay relative to control | |||
| AID359085 | Increase in osteopontin mRNA levels in mouse MC3T3-E1 cells at 1 uM after 72 hrs by RT-PCR | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1379010 | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured up to 180 secs by spectrophotometric analysis | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease. |
| AID1379020 | Inhibition of HFIP pretreated amyloid beta (1 to 42) (unknown origin) self-aggregation at 20 uM after 48 hrs by thioflavin T fluorescence assay relative to control | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease. |
| AID1884060 | Antibacterial activity against Staphylococcus aureus LMG 8224 incubated for 20 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID359115 | Reversal of increase in BMP2 expression in mouse MC3T3-E1 cells expressing pBMP2/mERE mutant at 1 uM after 4 hrs by luciferase method | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID432155 | Inhibition of heat killed Escherichia coli K12-induced TNF alpha production in mouse RAW264.7 cells at 1 to 100 uM after 6 hrs by ELISA | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID432159 | Inhibition of FSL1-induced upregulation of MSR1 mRNA expression in in human THP1 cells at 100 uM after 1 hr by RT-PCR | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID1309176 | Inhibition of Cu2+-induced amyloid beta (1 to 40) fibril aggregation assessed as remaining fibril aggregates at 100 uM preincubated for 5 mins followed by amyloid beta (1 to 40) addition measured after 3 days at pH 6.60 by thioflavin-T fluorescence assay | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Ionophoric polyphenols selectively bind Cu(2+), display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila. |
| AID638054 | Antibacterial activity against CagA-expressing Helicobacter pylori 17C7 isolated from gastric carcinoma patient after 48 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1182051 | Induction of quinone reductase 1 in mouse Hepa-1c1c7 cells after 48 hrs by MTT assay | 2014 | Journal of natural products, Jul-25, Volume: 77, Issue:7 | Spongiapyridine and related spongians isolated from an Indonesian Spongia sp. |
| AID359114 | Increase in BMP2 expression in mouse MC3T3-E1 cells expressing pBMP2delta2 mutant at 1 uM after 4 hrs by luciferase method relative to control | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID430021 | Antiproliferative activity against P-gp expressing human DLKP-A cells after 5 days by acid phosphatase assay | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13 | Synthesis, structural characterisation and biological evaluation of fluorinated analogues of resveratrol. |
| AID501908 | Inhibition of human carbonic anhydrase 5b after 15 mins by stopped flow CO2 hydration method | 2010 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17 | Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. |
| AID1298271 | Antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as reduction in viral infectivity at 50 uM incubated for 4 hrs prior to viral infection measured at 72 hrs post infection by flow cytometric analysis | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1168357 | Hepatoprotective activity against isoniazid-rifampicin induced liver injury in BALB/c mouse assessed as increase in catalase activity depletion at 100 mg/kg, po bid for 3 days starting 30 mins prior isoniazid-rifampicin administration measured 24 hrs post | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. |
| AID718777 | Inhibition of amyloid beta (1-42) aggregation at 20 uM after 48 hrs by thioflavin T fluorescence method relative to control | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Design, synthesis, and evaluation of resveratrol derivatives as Aß(₁-₄₂) aggregation inhibitors, antioxidants, and neuroprotective agents. |
| AID1480854 | Inhibition of amyloid beta (1 to 42) (unknown origin) fibril formation at 20 uM measured up to 48 hrs by uranyl acetate staining based transmission electron microscopy | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment. |
| AID719274 | Induction of quinone reductase-1 activity in mouse TAOc1BPrc1 cells after 48 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1). |
| AID1351441 | Upregulation of cleaved caspase-3 levels in malignant hepatic tissue of cancer patient at 5 g/day, po administered for 10 to 21 days by immunohistochemistry relative to control | 2018 | European journal of medicinal chemistry, Jan-20, Volume: 144 | Natural compounds and combination therapy in colorectal cancer treatment. |
| AID1467690 | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assay relative to AITC | 2017 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14 | Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor. |
| AID359504 | Effect on growth differentiation factor 10 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID67900 | the minimum inhibitory concentration (MIC) that inhibits all visible growth of the Enterococcus faecalis (bacteria) at 64 ug/ml | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID359071 | Increase in proliferation of human MG63 cells at 0.1 to 10 uM after 24 hr by flow cytometry | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1878994 | Inhibition of TGF-beta1 induced apoptosis in C57/B6J mouse primary hepatocytes assessed as increase in Bcl-2 expression at 10 to 50 uM by Western blot analysis | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID1298350 | Antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as increase in frequency of A to T transversion at 50 uM incubated for 4 hrs prior to infection measured at 72 hrs post infection by illumina sequencing me | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1245574 | Antiproliferative activity against human MDA-MB-231 cells assessed as cell survival at 100 uM after 24 hrs by MTT assay relative to control | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Deprotometalation-iodolysis and computed CH acidity of 1,2,3- and 1,2,4-triazoles. Application to the synthesis of resveratrol analogues. |
| AID719285 | Inhibition of mushroom tyrosinase using L-tyrosine as substrate at 20 uM after 30 mins by spectrophotometric analysis | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis of novel azo-resveratrol, azo-oxyresveratrol and their derivatives as potent tyrosinase inhibitors. |
| AID1879024 | Antifibrotic activity in CCL-4 induced liver fibrosis C57/B6J mouse model assessed as reduction in serum AST level at 100 mg/kg/day, ip measured after 72 hrs post last dose by ELISA | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID642090 | Inhibition of human aromatase using dibenzylfluorescein as substrate at 50 uM preincubated for 30 mins measured after 2 hrs by fluorimetry | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets. |
| AID1362755 | Immunomodulatory activity in LPS-stimulated mouse RAW264.7 cells assessed as decrease in MHC-2 expression at 50 uM incubated with LPS for 1 hr followed by compound addition measured after 24 hrs by flow cytometry | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues. |
| AID251315 | Percent of apoptosis in MDA MB 468 Cell line determined by Annexin-V-FITC/PI analysis at 10 uM | 2005 | Journal of medicinal chemistry, Feb-24, Volume: 48, Issue:4 | Synthesis, antitumor evaluation, and apoptosis-inducing activity of hydroxylated (E)-stilbenes. |
| AID432156 | Inhibition of heat killed Escherichia coli K12-induced TNF alpha production in human THP1 cells at 1 to 100 uM after 6 hrs by ELISA | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID1152217 | Binding affinity to rat brain cell membrane | 2014 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 24, Issue:12 | Cell membrane mediated (-)-epicatechin effects on upstream endothelial cell signaling: evidence for a surface receptor. |
| AID1298351 | Antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as increase in frequency of T to A transversion at 50 uM incubated for 4 hrs prior to infection measured at 72 hrs post infection by illumina sequencing me | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1362636 | Antioxidant activity assessed as AAPH radical scavenging activity at 1 to 16 uM by ORAC assay | |||
| AID1420918 | Antibacterial activity against Bacillus subtilis after 17 hrs by NCCLS broth microdilution method | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Antibacterial and antioxidant activities for natural and synthetic dual-active compounds. |
| AID359078 | Increase in ALP activity in rat primary osteoblast cells at 0.1 to 10 uM after 7 days | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1272530 | Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as induction of intracellular calcium level in absence of AITC | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | TRPA1 channels as targets for resveratrol and related stilbenoids. |
| AID730556 | Antinociceptive activity in Swiss mouse assessed as inhibition of glutamate-induced increase of c-Fos expression in brain cortex at 100 mg/kg, po by immunohistochemistry analysis | 2013 | Journal of natural products, Jan-25, Volume: 76, Issue:1 | Evidence for the analgesic activity of resveratrol in acute models of nociception in mice. |
| AID402926 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 2 after 24 hrs | 2004 | Journal of natural products, Jun, Volume: 67, Issue:6 | New stilbene derivatives from Calligonum leucocladum. |
| AID1647483 | Inhibition of PTP1B (unknown origin) assessed as decrease in p-nitrophenolate formation using using pNPP as substrate incubated for 15 mins by spectrophotometric method | 2020 | Journal of natural products, 02-28, Volume: 83, Issue:2 | Stilbenes with Potent Protein Tyrosine Phosphatase-1B Inhibitory Activity from the Roots of |
| AID331040 | Activation of human SIRT1 expressed in Escherichia coli BL21 by mass spectrometry assay | 2007 | Nature, Nov-29, Volume: 450, Issue:7170 | Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. |
| AID1278617 | Cytotoxicity against human HepG2 cells at 2.5 to 10 uM by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog. |
| AID568507 | Induction of NQO1 activity in mouse Hepa1c1c7 cells assessed as concentration required to twofold increase of NQO1 activity at IC50 concentration relative to control | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties. |
| AID1872741 | Antioxidant activity assessed as DPPH radical scavenging activity measured after 20 mins | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy. |
| AID730940 | Antinociceptive activity in Swiss mouse assessed as inhibition of glutamate-induced increase of c-Fos expression in L3-L6 spinal segments at 100 mg/kg, po by immunohistochemistry analysis | 2013 | Journal of natural products, Jan-25, Volume: 76, Issue:1 | Evidence for the analgesic activity of resveratrol in acute models of nociception in mice. |
| AID1371379 | Cytotoxicity against human LN229 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID549837 | Activity at AhR expressed in mouse H1L1.1c2 cells co-expressing XRE assessed as induction luciferase gene expression at 1 uM after 72 hrs relative to benzo[b]fluoranthene | 2011 | Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1 | New hydroxystilbenoid derivatives endowed with neuroprotective activity and devoid of interference with estrogen and aryl hydrocarbon receptor-mediated transcription. |
| AID1298388 | Effect on dRGU-TP level in human U373-MAGI cells at 50 uM preincubated for 2 hrs followed by 5-aza-dC addition measured after 4 hrs by LC-MS/MS analysis | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1298406 | Antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as increase in mutation frequency at 50 uM incubated for 4 hrs prior to infection measured at 72 hrs post infection by illumina sequencing method | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1879025 | Antifibrotic activity in CCL-4 induced liver fibrosis C57/B6J mouse model assessed as reduction in serum ALT level at 100 mg/kg/day, ip measured after 72 hrs post last dose by ELISA | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID759448 | Induction of disaggregation of Cu2+-induced amyloid beta (1 to 42) fibril (unknown origin) at 50 uM after 24 hrs by thioflavin T fluorescence assay relative to control | 2013 | Journal of medicinal chemistry, Jul-25, Volume: 56, Issue:14 | Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease. |
| AID1674578 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 after 24 hrs by broth microdilution method | 2020 | Journal of natural products, 08-28, Volume: 83, Issue:8 | Generation of Stilbene Antimicrobials against Multiresistant Strains of |
| AID432148 | Inhibition of FSL-1-induced increase in phagocytosis of FITC-conjugated Escherichia coli K12 in human THP1 cells assessed as reduction in number of cells phagocytosing bacteria per cell after 1 hr by CLSM | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID1878978 | Inhibition of TGF-beta1 induced apoptosis in C57/B6J mouse primary hepatocytes assessed as live cells by Annexin-V-FITC-H and PI staining based flow cytometry analysis (Rvb = 64.40 %) | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID468428 | AUC in intragastrically dosed rat assessed as total metabolite level at 0.09 mmol/kg after 10 mins | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | Soluble polyphenols: synthesis and bioavailability of 3,4',5-tri(alpha-D-glucose-3-O-succinyl) resveratrol. |
| AID650853 | Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells after 18 hrs | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7 | Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol. |
| AID1335884 | Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Discovery of oral-available resveratrol-caffeic acid based hybrids inhibiting acetylated and phosphorylated STAT3 protein. |
| AID1371385 | Cytotoxicity against human NCI-H460 cells assessed as cell viability at 16 uM after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1370960 | Inhibition of SIRT1 (unknown origin) assessed as reduction in Fluor de Lys deacetylation at 10 to 20 uM incubated for 5 mins followed by substrate addition measured after 45 mins in presence of NAD/NADH by fluorescence assay | 2018 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 28, Issue:3 | SIRT1 activator isolated from artificial gastric juice incubate of total saponins in stems and leaves of Panax ginseng. |
| AID610235 | Antiinflammatory activity in C57BL/6J mouse model of DSS-induced colon inflammation assessed as reduction in PGE2 level at 2.1 mg/kg/day, po for 21 days followed by compound dosing for 8 days co-administered with DSS followed by 2.1 mg/kg/day, po dosing f | 2010 | Journal of medicinal chemistry, Oct-28, Volume: 53, Issue:20 | Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents. |
| AID713104 | Drug metabolism assessed as oxidation of the compound at 100 uM after 10 mins by UV-vis spectrophotometric analysis in the presence of tyrosinase | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID1534711 | Inhibition of human MAO-A preincubated for 15 mins followed by p-tyramine substrate addition and measured after 20 mins by Amplex red reagent based fluorescence assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease. |
| AID347336 | Activation of human SIRT1 expressed in Escherichia coli BL21Start assessed as maximum activation of enzyme activity by mass spectrometry assay | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5 | Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators. |
| AID1298412 | Antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as reduction in U5-gag level at 50 uM measured at 6 hrs post infection by qPCR method | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1333782 | Cytotoxicity against human HCT116 cells assessed as cell growth inhibition after 48 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1 | Synthesis and bioactivity evaluation of 2,3-diaryl acrylonitrile derivatives as potential anticancer agents. |
| AID1309177 | Inhibition of Cu2+-induced amyloid beta (1 to 40) fibril aggregation assessed as remaining fibril aggregates at 100 uM preincubated for 5 mins followed by amyloid beta (1 to 40) addition measured after 7 days at pH 6.60 by thioflavin-T fluorescence assay | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Ionophoric polyphenols selectively bind Cu(2+), display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila. |
| AID1519073 | Stability of compound in DMSO at 10 mM incubated for 24 hrs by HPLC analysis | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | From bench to counter: Discovery and validation of a peony extract as tyrosinase inhibiting cosmeceutical. |
| AID1362751 | Antiproliferative activity against Con-A-induced T cells isolated from splenocytes of C57/BL6 mouse at 50 uM incubated with Con-A for 1 hr followed by compound addition measured after 72 hrs by MTT assay | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues. |
| AID359100 | Reduction in anchorage-independent colony formation of human T47D cells at 1 uM by soft agar colony forming assay | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1430668 | Octanol/phosphate buffer partition co-efficient, log D of the compound at 75 uM at pH 7.4 after 2 hrs by LC-Ms/MS based shake-flask method | 2017 | ACS medicinal chemistry letters, May-11, Volume: 8, Issue:5 | Toward Resolving the Resveratrol Conundrum: Synthesis and |
| AID1461522 | Antioxidant activity assessed as DPPH free radical scavenging activity incubated for 30 mins | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Synthesis and evaluation of hydroxychalcones as multifunctional non-purine xanthine oxidase inhibitors for the treatment of hyperuricemia. |
| AID692944 | Cytotoxicity against human LS 174T cells at 10 uM for 2 days by vi-cell cell viability analysis | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID359094 | Inhibition of TNF-alpha-induced apoptosis in mouse MC3T3-E1 cells after 24 hrs by flow cytometry | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID738197 | Inhibition of smad3/4 signaling pathway in human HeLa cells assessed as inhibition of TGF-beta induced luciferase treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID1406254 | Inhibition of human AChE using acetylthiocholine iodide as substrate assessed as residual activity at 10 uM preincubated for 5 mins followed by substrate addition and measured for 1 min by Ellman's assay relative to control | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities. |
| AID721440 | Antitumor activity against human MCF7 cells assessed as growth inhibition measured after 48 hrs by MTT assay | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Bioactive barrigenol type triterpenoids from the leaves of Xanthoceras sorbifolia Bunge. |
| AID359330 | Effect on procollagen 2 alpha 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID432165 | Inhibition of phagocytosis of heat killed FITC-conjugated Staphylococcus aureus 209P in HEK293 at 100 uM after 1 hr | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID738187 | Inhibition of Myc signaling pathway in human HeLa cells assessed as inhibition of PMA induced luciferase treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID1256167 | Antibacterial activity in Chromobacterium violaceum CV026 at >50 ug/well by agar-well diffusion method | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | The quorum-sensing inhibiting effects of stilbenoids and their potential structure-activity relationship. |
| AID1418623 | Inhibition of HFIP-pretreated amyloid beta (1 to 42) (unknown origin) self-induced aggregation after 24 hrs by thioflavin-T fluorescence assay | 2018 | Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22 | Resveratrol-maltol hybrids as multi-target-directed agents for Alzheimer's disease. |
| AID359077 | Increase in ALP activity in human MG63 cells at 0.1 to 10 uM after 7 days | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID416363 | Cytotoxicity against human HL60 cells after 48 hrs by MTT assay | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6 | 4,4'-Dihydroxy-trans-stilbene, a resveratrol analogue, exhibited enhanced antioxidant activity and cytotoxicity. |
| AID1278605 | Inhibition of ovine COX-1 using arachidonic acid as substrate assessed as PGE2 production preincubated for 10 mins followed by substrate addition incubated for 2 mins by ELISA | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog. |
| AID608337 | Antibacterial activity against 1 x 10'4 cfu/mL Bacillus subtilis ATCC 33712 after 24 hrs by NCCLS M7-A6 microtiter broth dilution method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis and antimicrobial evaluation of new benzofuran derivatives. |
| AID294469 | Cytotoxicity against mouse Hepa 1c1c7 cells assessed as cell viability at 12.5 uM after 24 hrs by MTT assay | 2007 | European journal of medicinal chemistry, Jun, Volume: 42, Issue:6 | Quinone reductase induction activity of methoxylated analogues of resveratrol. |
| AID1317148 | Drug absorption in human at 50 uCi, po up to 12 hrs using 14C-labeled compound by scintillation counting method | 2016 | European journal of medicinal chemistry, Aug-25, Volume: 119 | How much successful are the medicinal chemists in modulation of SIRT1: A critical review. |
| AID1362750 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production by measuring TNFalpha levels incubated with LPS for 1 hr followed by compound addition measured after 48 hrs by ELISA (Rvb = 58.6 +/- 7.4 ng/ml) | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues. |
| AID416975 | Induction of DNA fragmentation in human HL60 cells at 150 uM after 48 hrs by ethidium bromide based gel electrophoresis | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7 | Antioxidant-based lead discovery for cancer chemoprevention: the case of resveratrol. |
| AID1311772 | Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as iNOS levels at 5 umol/L by ELISA (Rvb = 31.63 +/- 3.26 U/mL) | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata. |
| AID1298275 | Cytotoxicity against human U373-MAGI cells at 50 uM measured at 72 hrs by Celltiter-Glo luminescent cell viability assay | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1168372 | Hepatoprotective activity against isoniazid-rifampicin induced liver injury in BALB/c mouse assessed as reduction in PPAR-gamma mRNA level at 100 mg/kg, po bid for 3 days starting 30 mins prior isoniazid-rifampicin administration measured 24 hrs post-last | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. |
| AID724375 | Cytotoxicity against human MCF7 cells at 100 uM after 24 hrs by MTS assay | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Dose-dependent interaction of trans-resveratrol with biomembranes: effects on antioxidant property. |
| AID1168379 | Hepatoprotective activity against isoniazid-rifampicin induced liver injury in BALB/c mouse assessed as reduction in IL-10 level at 100 mg/kg, po bid for 3 days starting 30 mins prior isoniazid-rifampicin administration measured 24 hrs post-last dose of i | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. |
| AID1566059 | Cytotoxicity against human TOV112D cells expressing NQO2 assessed as reduction in cell viability incubated for 96 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2). |
| AID1371455 | Plasma concentration in mouse at 10 mg/kg, iv at 60 mins by LC-MS/MS method | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID239674 | Binding affinity for estrogen receptor (ER) alpha of MCF-7 cell cytosol incubated with 2 nM [3H]estradiol; Agonist | 2005 | Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1 | Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. |
| AID696072 | Stability in RPMI medium at 37 degC assessed as compound degradation incubated for 24 hrs | 2011 | Journal of medicinal chemistry, Aug-11, Volume: 54, Issue:15 | Polysulfated xanthones: multipathway development of a new generation of dual anticoagulant/antiplatelet agents. |
| AID1245576 | Antiproliferative activity human MDA-MB-231 cells assessed as cell survival after 48 hrs by MTT assay | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Deprotometalation-iodolysis and computed CH acidity of 1,2,3- and 1,2,4-triazoles. Application to the synthesis of resveratrol analogues. |
| AID762892 | Inhibition of H2O2-induced HUVEC senescence pretreated for 1 day followed by compound washout and H2O2-treatment measured after 10 days by SA-beta galactosidase staining-based assay | 2013 | Journal of natural products, Jul-26, Volume: 76, Issue:7 | trans-Resveratrol in Gnetum gnemon protects against oxidative-stress-induced endothelial senescence. |
| AID1878991 | Inhibition of TGF-beta1 induced apoptosis in C57/B6J mouse primary hepatocytes assessed as early apoptotic cells at 50 uM by Annexin-V-FITC-H and PI staining based flow cytometry analysis (Rvb = 18.71 %) | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID1305341 | Inhibition of self-induced amyloid beta 40 (unknown origin) aggregation measured for 24 hrs by thioflavin T-based fluorescence spectroscopic analysis | 2016 | ACS medicinal chemistry letters, May-12, Volume: 7, Issue:5 | Structure-Activity Relationship Studies of Isomeric 2,4-Diaminoquinazolines on β-Amyloid Aggregation Kinetics. |
| AID1396267 | Antiproliferative activity against human CAR cells after 72 hrs by MTT assay | 2018 | Bioorganic & medicinal chemistry, 08-07, Volume: 26, Issue:14 | Synthesis and antitumor activity of bis(hydroxymethyl)propionate analogs of pterostilbene in cisplatin-resistant human oral cancer cells. |
| AID359109 | Reversal of increase in ER.DNA complex in rat primary osteoblast cells at 1 uM by RT-PCR in presence of PP2 | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1519075 | Cytotoxicity against C57BL/6 mouse B16F10 cells assessed as increase in membrane blebbing at 50 uM incubated for 48 hrs by microscopic method | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | From bench to counter: Discovery and validation of a peony extract as tyrosinase inhibiting cosmeceutical. |
| AID1879008 | Inhibition of TGF-beta1 induced apoptosis in C57/B6J mouse primary hepatocytes assessed as live cells in presence of miR-190a-5p mimic by Annexin-V-FITC-H and PI staining based flow cytometry analysis (Rvb = 64.40 %) | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID1309165 | Binding affinity to Mg2+ using MgSO4 at 20 uM after 5 mins by spectrophotometry | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Ionophoric polyphenols selectively bind Cu(2+), display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila. |
| AID1674577 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 after 24 hrs by broth microdilution method | 2020 | Journal of natural products, 08-28, Volume: 83, Issue:8 | Generation of Stilbene Antimicrobials against Multiresistant Strains of |
| AID458147 | Antimicrobial activity against Streptococcus sanguinis NCTC 9811 at 200 ug/ml after 20 hrs by disk diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | The antimicrobial activity of compounds from the leaf and stem of Vitis amurensis against two oral pathogens. |
| AID713101 | Activation of mushroom tyrosinase assessed as L-DOPA oxidation at 100 uM after 30 mins by UV-vis spectrophotometric analysis | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID457446 | Cytotoxicity against human PANC1 cells at 50 uM after 72 hrs by WST-1 assay in presence of gemcitabine | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | Synthesis of 4'-ester analogs of resveratrol and their evaluation in malignant melanoma and pancreatic cell lines. |
| AID620776 | Induction of apoptosis in human HeLa cells assessed as increase in caspase 3 activity at 5 uM after 24 hrs by fluorimetry | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19 | Design and synthesis of resveratrol-based nitrovinylstilbenes as antimitotic agents. |
| AID1311779 | Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as COX2 levels at 5 umol/L by ELISA (Rvb = 159.64 +/- 13.56 pg/mL) | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata. |
| AID1467682 | Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx at 3 uM preincubated for 6 mins followed by AITC addition measured for 1 min by Fluo-4 dye-based assay relative to control | 2017 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14 | Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor. |
| AID1390538 | Inhibition of aromatase (unknown origin) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Studies on non-steroidal inhibitors of aromatase enzyme; 4-(aryl/heteroaryl)-2-(pyrimidin-2-yl)thiazole derivatives. |
| AID1418635 | Disaggregation of Cu2+-induced amyloid beta (1 to 42) (unknown origin) preformed fibrils assessed as remaining amyloid beta aggregation level at 50 mM after 24 hrs by thioflavin-T fluorescence assay | 2018 | Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22 | Resveratrol-maltol hybrids as multi-target-directed agents for Alzheimer's disease. |
| AID1326318 | Antimicrobial activity against vancomycin-sensitive Enterococcus faecalis after 18 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24 | Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ. |
| AID638058 | Antibacterial activity against CagA-expressing Helicobacter pylori 1C1 isolated from gastric carcinoma patient after 48 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1083169 | Antifungal activity against Neofusicoccum parvum assessed as growth inhibition at 500 uM measured after 1 to 10 days relative to control | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID1879031 | Antifibrotic activity in CCL-4 induced liver fibrosis C57/B6J mouse model transfected with miR-190a-5p agomir assessed as increase in bilirubin level in serum at 100 mg/kg/day, ip measured after 72 hrs post last dose by ELISA | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID724381 | Antioxidant activity assessed as DPPH free radical scavenging activity at >100 uM after 45 mins by UV-visible spectrophotometric analysis relative to vitamin C | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Dose-dependent interaction of trans-resveratrol with biomembranes: effects on antioxidant property. |
| AID294474 | Induction of quinone reductase activity in mouse Hepa 1c1c7 cells at 12.5 uM after 24 hrs relative to control | 2007 | European journal of medicinal chemistry, Jun, Volume: 42, Issue:6 | Quinone reductase induction activity of methoxylated analogues of resveratrol. |
| AID1261080 | Selectivity ratio of IC50 for HEK293 cells to IC50 for human HT-29 cells | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Inhibitory effect of cytotoxic stilbenes related to resveratrol on the expression of the VEGF, hTERT and c-Myc genes. |
| AID1371369 | Cytotoxicity against human T47D cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID432152 | Inhibition of heat killed Staphylococcus aureus 209P-induced NF-kappaB activation in HEK293 cells expressing TLR2 pretreated for 1 hr before 6 hrs heat killed bacterial stimulation by luciferase reporter gene assay | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID1826671 | Antioxidant activity assessed as trolox equivalent of ORAC radical scavenging activity preincubated for 15 mins followed by AAPH addition by ORAC-FL assay | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades. |
| AID1879020 | Antifibrotic activity in CCL-4 induced liver fibrosis C57/B6J mouse model assessed as increase in HGF expression at 100 mg/kg/day, ip measured after 72 hrs post last dose by Western blot analysis | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID735495 | Activation of SIRT1 in human MCF7 cells assessed as reduction in doxorubicin-induced acetyl-p53 level at <100 uM after 6 hrs by Western blotting analysis | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate. |
| AID264592 | Antiproliferative activity against human K562 cell line expressing Bcr-Abl | 2006 | Journal of medicinal chemistry, May-18, Volume: 49, Issue:10 | Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. |
| AID724376 | Antioxidant activity in planer lipid bilayer membrane assessed as reduction in 100 uM DPPH-induced charge transfer resistance at 100 uM by admittance spectroscopic analysis | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Dose-dependent interaction of trans-resveratrol with biomembranes: effects on antioxidant property. |
| AID359194 | Effect on ascorbic acid production from dehydroascorbic acid in human HL60 cells at >500 uM by HPLC | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3 | Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells. |
| AID359175 | Inhibition of 2-[1,2-3H(N)]deoxy-D-glucose uptake in human HL60 cells by Michaelis-Menten plot | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3 | Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells. |
| AID610239 | Antiinflammatory activity in C57BL/6J mouse model of DSS-induced colon inflammation assessed as reduction of colon MIP1gamma level at 2.1 mg/kg/day, po for 21 days followed by compound dosing for 8 days co-administered with DSS followed by 2.1 mg/kg/day, | 2010 | Journal of medicinal chemistry, Oct-28, Volume: 53, Issue:20 | Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents. |
| AID598386 | Inhibition of tyrosinase | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | New halogenated phenylcoumarins as tyrosinase inhibitors. |
| AID1062137 | Antibiofilm activity against Escherichia coli O157:H7 assessed as repression of csgC expression at 20 ug/ml after 5 hrs by qRT-PCR analysis | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1 | Resveratrol oligomers inhibit biofilm formation of Escherichia coli O157:H7 and Pseudomonas aeruginosa. |
| AID614089 | Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by sulforhodamine-B colorimetric assay | 2011 | Bioorganic & medicinal chemistry, Sep-01, Volume: 19, Issue:17 | Synthesis and antimicrobial activity of (E) stilbene derivatives. |
| AID595051 | Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry, Apr-15, Volume: 19, Issue:8 | Synthesis, biological evaluation, and molecular docking studies of resveratrol derivatives possessing chalcone moiety as potential antitubulin agents. |
| AID1371388 | Cytotoxicity against human MML1 cells assessed as cell viability at 16 uM after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID478951 | Antiproliferative activity against human A431 cells after 72 hrs | 2010 | Bioorganic & medicinal chemistry, May-15, Volume: 18, Issue:10 | Design, synthesis and anticancer activities of stilbene-coumarin hybrid compounds: Identification of novel proapoptotic agents. |
| AID1461517 | Inhibition of bovine milk xanthine oxidase pre-incubated for 30 mins followed by xanthine addition and measured every 30 secs for 5 mins by spectrophotometry | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Synthesis and evaluation of hydroxychalcones as multifunctional non-purine xanthine oxidase inhibitors for the treatment of hyperuricemia. |
| AID420374 | Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15 | Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. |
| AID359535 | Effect on transforming growth factor beta 2 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1428597 | Antioxidant activity assessed as ABTS radical scavenging activity incubated for 10 mins under dark condition | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Synthesis and biological evaluation of deferiprone-resveratrol hybrids as antioxidants, Aβ |
| AID1371390 | Cytotoxicity against human U87 cells assessed as cell viability at 16 uM after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID259473 | Cytotoxicity against neuroblastoma SHSY5Y cell line by MTT assay at 100 uM | 2006 | Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2 | Rapid synthesis of triazole-modified resveratrol analogues via click chemistry. |
| AID730562 | Antinociceptive activity in Swiss mouse assessed as inhibition of glutamate-induced spontaneous nociception at 300 ug/site, icv | 2013 | Journal of natural products, Jan-25, Volume: 76, Issue:1 | Evidence for the analgesic activity of resveratrol in acute models of nociception in mice. |
| AID337726 | Cytotoxicity against mouse 3PS cells xenografted in mouse at 37 mg/kg relative to control | |||
| AID650842 | Inhibition of human aromatase using dibenzylfluorescein substrate preincubated for 30 mins measured after 30 mins by fluorescence assay | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7 | Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol. |
| AID1607875 | Inhibition of COX2 (unknown origin) at 0.01 mM after 15 mins by ELISA relative to control | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Human disorders associated with inflammation and the evolving role of natural products to overcome. |
| AID1594639 | Cytoprotective effect against high glucose-induced oxidative stress in HUVEC assessed as cell viability at 5 uM incubated by MTT assay (Rvb = 72.1 to 77.9%) | 2019 | Journal of natural products, 06-28, Volume: 82, Issue:6 | Isolation, Chiral-Phase Resolution, and Determination of the Absolute Configurations of a Complete Series of Stereoisomers of a Rearranged Acetophenone with Three Stereocenters. |
| AID359529 | Effect on platelet derived growth factor alpha gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID642334 | Induction of QR1 activity in mouse BPrc1 cells using MTT as substrate assessed as induction ratio by spectrophotometry relative to control | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets. |
| AID1596636 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at 10 uM pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Novel resveratrol-based flavonol derivatives: Synthesis and anti-inflammatory activity in vitro and in vivo. |
| AID432142 | Inhibition of phagocytosis of FITC-conjugated Escherichia coli K12 in human THP1 cells assessed as reduction in ratio of number of bacterial cells to phagocytes using trypan blue staining by flow cytometry | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID1237125 | Half life of the compound | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15 | Design, synthesis and biological evaluation of paralleled Aza resveratrol-chalcone compounds as potential anti-inflammatory agents for the treatment of acute lung injury. |
| AID1261707 | Antioxidant activity assessed as trolox equivalent of AAPH radical scavenging activity preincubated for 10 mins followed by AAPH challenge measured every min for 120 mins by ORAC-FL assay | 2015 | Journal of medicinal chemistry, Nov-12, Volume: 58, Issue:21 | Design, Synthesis, and Evaluation of Orally Available Clioquinol-Moracin M Hybrids as Multitarget-Directed Ligands for Cognitive Improvement in a Rat Model of Neurodegeneration in Alzheimer's Disease. |
| AID1616104 | Inhibition of ATP synthase isolates from rat brain cells using succinate as substrate preincubated for 5 mins followed by substrate addition | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Recent advancements in mechanistic studies and structure activity relationship of F |
| AID501912 | Inhibition of human carbonic anhydrase 12 after 15 mins by stopped flow CO2 hydration method | 2010 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17 | Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. |
| AID336155 | Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins | 2002 | Journal of natural products, Sep, Volume: 65, Issue:9 | New diarylheptanoids from the stems of Carpinus cordata. |
| AID724382 | Antioxidant activity assessed as DPPH free radical scavenging activity at <100 uM after 45 mins by UV-visible spectrophotometric analysis relative to vitamin C | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Dose-dependent interaction of trans-resveratrol with biomembranes: effects on antioxidant property. |
| AID713095 | Inhibition of mushroom tyrosinase-mediated oxygen consumption at 100 uM using L-DOPA substrate incubated 30 mins prior to substrate addition measured after 60 mins | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID1372019 | Antioxidant activity assessed as Trolox equivalents of photolysis-induced hydroxyl radical scavenging activity using DMPO spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID1884062 | Antibacterial activity against Staphylococcus aureus LMG 15975 incubated for 20 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID1362745 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS/IFNgamma-induced NO production by measuring NO levels incubated with LPS/IFNgamma for 1 hr followed by compound addition measured after 48 hrs by Griess assay (Rvb = 55 +/- 2. | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues. |
| AID1298311 | Reduction in dATP level in human U373-MAGI cells at 200 uM after 6 hrs by LC-MS/MS analysis | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID403340 | Inhibition of COX2 | 2005 | Journal of natural products, Jul, Volume: 68, Issue:7 | Expanding the ChemGPS chemical space with natural products. |
| AID725753 | Cytotoxicity against human MDA-MB-231 cells at 50 uM by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 23, Issue:3 | Novel Aza-resveratrol analogs: synthesis, characterization and anticancer activity against breast cancer cell lines. |
| AID1780364 | Antiproliferative activity against human MDA-MB-231 cells measured after 24 hrs by MTT assay | |||
| AID1362762 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS/IFNgamma-induced NO production at 50 uM incubated with LPS/IFNgamma for 1 hr followed by compound addition measured after 48 hrs by Griess assay relative to control | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues. |
| AID638053 | Antibacterial activity against CagA-expressing Helicobacter pylori 10Kb isolated from gastric carcinoma patient after 48 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID759458 | Antioxidant activity assessed as trolox equivalent of AAPH radical scavenging activity at 10 uM preincubated for 10 mins followed by AAPH challenge measured every min for 120 mins by ORAC-FL assay | 2013 | Journal of medicinal chemistry, Jul-25, Volume: 56, Issue:14 | Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease. |
| AID1278606 | Inhibition of human recombinant COX-2 using arachidonic acid as substrate assessed as PGE2 production preincubated for 10 mins followed by substrate addition incubated for 2 mins by ELISA | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog. |
| AID1281401 | Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Non-symmetrical furan-amidines as novel leads for the treatment of cancer and malaria. |
| AID1566058 | Cytotoxicity against human TOV112D cells transfected with empty vector assessed as reduction in cell viability incubated for 96 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2). |
| AID1155848 | Inhibition of tyrosinase in mouse Melan-a cells assessed as decrease in L-DOPA Vmax at 120 uM by Lineweaver-Burk plot | 2014 | Journal of natural products, Jun-27, Volume: 77, Issue:6 | Tyrosinase inhibitory activity of a glucosylated hydroxystilbene in mouse melan-a melanocytes. |
| AID1662943 | Antioxidant activity assessed as hydroxyl radical scavenging activity by spectrophotometric analysis | 2020 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 30, Issue:13 | Synthesis, biological evaluation of benzothiazole derivatives bearing a 1,3,4-oxadiazole moiety as potential anti-oxidant and anti-inflammatory agents. |
| AID359173 | Inhibition of 2-[1,2-3H(N)]deoxy-D-glucose uptake in human HL60 cells at 75 uM by scintillation spectrometry in presence of buffer containing NaCl and Na2HPO4 | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3 | Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells. |
| AID359308 | Effect on bone morphogenetic protein 8b gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1178158 | Antioxidant activity of the compound assessed as reduction in absorbance of DPPH after 60 mins incubation at 100 uM by DPPH radical scavenging /microplate assay | 2014 | Bioorganic & medicinal chemistry, May-01, Volume: 22, Issue:9 | Synthesis, antioxidant and photoprotection activities of hybrid derivatives useful to prevent skin cancer. |
| AID1326319 | Antibacterial activity against Klebsiella pneumoniae ATCC BAA-1144 after 18 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24 | Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ. |
| AID641149 | Inhibition of alpha-glucosidase activity of sucrase in rat small intestinal brush border membrane fraction using maltose as substrate at 400 uM after 30 mins | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Antidiabetogenic oligostilbenoids and 3-ethyl-4-phenyl-3,4-dihydroisocoumarins from the bark of Shorea roxburghii. |
| AID1054194 | Antiviral activity against HIV1 infected in human U373-MAGI cells assessed as G to A mutation at 50 uM (Rvb = 27%) | 2013 | Bioorganic & medicinal chemistry, Nov-15, Volume: 21, Issue:22 | 5,6-Dihydro-5-aza-2'-deoxycytidine potentiates the anti-HIV-1 activity of ribonucleotide reductase inhibitors. |
| AID289283 | Relaxing effect on guinea pig arteria pulmonalis ring assessed as reduction of force of contraction at 100 uM | 2007 | Bioorganic & medicinal chemistry, Sep-15, Volume: 15, Issue:18 | 'Bridged' stilbene derivatives as selective cyclooxygenase-1 inhibitors. |
| AID1298281 | Reduction in dTTP level in human U373-MAGI cells at 50 uM after 6 hrs by LC-MS/MS analysis | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID458144 | Antimicrobial activity against Streptococcus mutans KCTC 3065 at 600 ug/ml after 20 hrs by disk diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | The antimicrobial activity of compounds from the leaf and stem of Vitis amurensis against two oral pathogens. |
| AID1632222 | Selectivity index, ratio of CD50 against human MHRF cells to CD50 for human T24 cells after 48 hrs | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18 | Synthesis and anticancer activity of a hydroxytolan series. |
| AID724383 | Induction of destruction morphology in human erythrocytes up to 100 uM after 1 hr by cold field emission scanning electron microscopic analysis | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Dose-dependent interaction of trans-resveratrol with biomembranes: effects on antioxidant property. |
| AID1872755 | Antioxidant activity assessed as DPPH radical scavenging activity | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy. |
| AID1298365 | Antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as reduction in gag level at 50 uM measured at 12 to 72 hrs post infection by qPCR method | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID396462 | Inhibition of tyrosinase at 5 uM | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Synthesis and in vitro biological activity of retinyl polyhydroxybenzoates, novel hybrid retinoid derivatives. |
| AID396439 | Toxicity against human dermal fibroblasts | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Synthesis and in vitro biological activity of retinyl polyhydroxybenzoates, novel hybrid retinoid derivatives. |
| AID378676 | Inhibition of CK2 | 2006 | Journal of natural products, Jan, Volume: 69, Issue:1 | A common protein fold topology shared by flavonoid biosynthetic enzymes and therapeutic targets. |
| AID1365631 | Inhibition of human MAO-B using p-tyramine as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by fluorescence-based Amplex Red MAO assay | 2017 | Bioorganic & medicinal chemistry, 11-01, Volume: 25, Issue:21 | Design, synthesis, and evaluation of salicyladimine derivatives as multitarget-directed ligands against Alzheimer's disease. |
| AID357965 | Inhibition of aromatase from human placental microsomes | 2001 | Journal of natural products, Oct, Volume: 64, Issue:10 | Aromatase inhibitors from Broussonetia papyrifera. |
| AID1399534 | Inhibition of self-induced amyloid beta (1 to 42) (unknown origin) fibril formation at 20 uM after 24 hrs by uranyl acetate staining-based transmission electron microscopic method | 2018 | Bioorganic & medicinal chemistry, 09-01, Volume: 26, Issue:16 | Synthesis and evaluation of 1,2,3,4-tetrahydro-1-acridone analogues as potential dual inhibitors for amyloid-beta and tau aggregation. |
| AID501904 | Inhibition of human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration method | 2010 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17 | Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. |
| AID331049 | Activation of human SIRT1-C construct by mass spectrometry assay relative to control | 2007 | Nature, Nov-29, Volume: 450, Issue:7170 | Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. |
| AID614619 | Binding affinity to recombinant C1B domain of PKCalpha expressed in Escherichia coli BL21 (DE3) after 45 mins by fluorescence quenching assay | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18 | Chemical modifications of resveratrol for improved protein kinase C alpha activity. |
| AID1225521 | Reduction in proliferating cell nuclear antigen in prostate tissue expression in BPH-induced Sprague-Dawley rat model at 1 mg/kg, ip daily for 4 weeks by Western blot analysis | 2015 | Journal of natural products, Apr-24, Volume: 78, Issue:4 | Effects of resveratrol on benign prostatic hyperplasia by the regulation of inflammatory and apoptotic proteins. |
| AID491528 | Cytotoxicity against human MCF7 cells assessed as cell survival at 20 ug/ml after 72 hrs by sulforhodamine B method | 2010 | Journal of medicinal chemistry, Jul-08, Volume: 53, Issue:13 | Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. |
| AID738207 | Cytotoxicity against pig LLC-PK1 cells assessed as growth inhibition measured after 48 hrs by XTT assay | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID331041 | Activation of SIRT2 by mass spectrometry assay | 2007 | Nature, Nov-29, Volume: 450, Issue:7170 | Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. |
| AID1168378 | Hepatoprotective activity against isoniazid-rifampicin induced liver injury in BALB/c mouse assessed as reduction in IL-12p70 level at 100 mg/kg, po bid for 3 days starting 30 mins prior isoniazid-rifampicin administration measured 24 hrs post-last dose o | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. |
| AID1371383 | Cytotoxicity against human COLO201 cells assessed as cell viability at 16 uM after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1436091 | Inhibition of HFIP-induced human recombinant amyloid beta (1 to 40 residues) aggregation expressed in Escherichia coli measured over 24 hrs by ThT-based fluorescence spectroscopic method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | 2,4-Disubstituted quinazolines as amyloid-β aggregation inhibitors with dual cholinesterase inhibition and antioxidant properties: Development and structure-activity relationship (SAR) studies. |
| AID1298332 | Reduction in dRGU-TP level in human U373-MAGI cells at 50 uM preincubated for 2 hrs followed by 5-aza-C addition measured after 4 hrs by LC-MS/MS analysis | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1543526 | Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production pretreated for 30 mins followed by LPS-stimulation for 24 hrs by Griess assay | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Synthesis and evaluation of tetrahydroisoquinoline-benzimidazole hybrids as multifunctional agents for the treatment of Alzheimer's disease. |
| AID1519068 | Antimelanogenic activity against C57BL/6 mouse B16F10 cells incubated for 10 to 50 uM incubated for 24 hrs | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | From bench to counter: Discovery and validation of a peony extract as tyrosinase inhibiting cosmeceutical. |
| AID1261708 | Permeability of the compound at 100 ug/ml after 10 hrs by PAMPA assay | 2015 | Journal of medicinal chemistry, Nov-12, Volume: 58, Issue:21 | Design, Synthesis, and Evaluation of Orally Available Clioquinol-Moracin M Hybrids as Multitarget-Directed Ligands for Cognitive Improvement in a Rat Model of Neurodegeneration in Alzheimer's Disease. |
| AID402925 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 4 after 24 hrs | 2004 | Journal of natural products, Jun, Volume: 67, Issue:6 | New stilbene derivatives from Calligonum leucocladum. |
| AID471944 | Growth inhibition of human BxPC3 cells after 48 hrs by sulforhodamine B assay | 2009 | Journal of natural products, Sep, Volume: 72, Issue:9 | Antineoplastic agents. 579. Synthesis and cancer cell growth evaluation of E-stilstatin 3: a resveratrol structural modification. |
| AID1879015 | Downregulation of cleaved-caspase3 expression in TGF-beta1 induced C57/B6J mouse primary hepatocytes in presence of miR-190a-5p mimic by Western blot analysis | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID359093 | Inhibition of etoposide-induced apoptosis in mouse MC3T3-E1 cells after 24 hrs by flow cytometry | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1362757 | Antiinflammatory activity in croton oil-induced Balb/c mouse ear edema model assessed as inhibition of leucocyte infiltration at 0.1 mg/ear administered topically immediately post croton oil treatment and measured after 4 hrs by hematoxylin and eosin stai | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues. |
| AID432134 | Inhibition of phagocytosis of FITC-conjugated Escherichia coli K12 in mouse RAW264.7 cells using trypan blue staining after 60 mins by flow cytometry | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID1464282 | Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay | 2017 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 27, Issue:20 | Natural neuro-inflammatory inhibitors from Caragana turfanensis. |
| AID471949 | Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay | 2009 | Journal of natural products, Sep, Volume: 72, Issue:9 | Antineoplastic agents. 579. Synthesis and cancer cell growth evaluation of E-stilstatin 3: a resveratrol structural modification. |
| AID1480844 | Antioxidant activity assessed as trolox equivalent of AAPH-induced radical scavenging activity at 1 uM pretreated for 15 mins followed by APPH challenge measured every minute for 240 mins by ORAC-FL assay | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment. |
| AID639327 | Antibacterial activity against CagA-expressing Helicobacter pylori 10K isolated from gastric carcinoma patient after 24 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID416676 | Cytotoxicity against human CEM cells after 72 hrs by MTT assay | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Synthesis and biological evaluation of cytotoxic properties of stilbene-based resveratrol analogs. |
| AID404515 | Binding affinity to human serum albumin at 4 uM by UV-vis measurement | 2008 | Bioorganic & medicinal chemistry, Jun-15, Volume: 16, Issue:12 | Design, synthesis and spectroscopic studies of resveratrol aliphatic acid ligands of human serum albumin. |
| AID1210975 | Terminal half life in C57BL/6 mouse at 15 mg/kg, iv | 2013 | Drug metabolism and disposition: the biological fate of chemicals, May, Volume: 41, Issue:5 | Pulmonary metabolism of resveratrol: in vitro and in vivo evidence. |
| AID146551 | In vitro growth inhibition of NCI-H460 (human non-small cell lung carcinoma) cell line. | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID1210980 | Drug metabolism in human lung S9 fractions assessed as trans-resveratrol-3-sulfate formation preincubated for 3 mins followed by PAPS addition measured after 60 mins by Eadie-Hofstee plot analysis | 2013 | Drug metabolism and disposition: the biological fate of chemicals, May, Volume: 41, Issue:5 | Pulmonary metabolism of resveratrol: in vitro and in vivo evidence. |
| AID416694 | Antimitotic activity in Lytechinus variegatus embryo assessed as inhibition of third cleavage at 43.8 uM relative to control | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Synthesis and biological evaluation of cytotoxic properties of stilbene-based resveratrol analogs. |
| AID455040 | Cytotoxicity against human A498 cells after 48 hrs by sulforhodamine B assay | 2009 | Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18 | E-Combretastatin and E-resveratrol structural modifications: antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes. |
| AID264599 | Induction of differentiation of human HL60 cells at 10 uM measured as expression of monocytic marker CD14 after 4 days | 2006 | Journal of medicinal chemistry, May-18, Volume: 49, Issue:10 | Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. |
| AID1616105 | Inhibition of ATP synthase in Escherichia coli | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Recent advancements in mechanistic studies and structure activity relationship of F |
| AID359320 | Effect on procollagen 11alpha 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1333793 | Antibacterial activity Streptococcus mutans 3289 at 64 ug/ml after 24 hrs by serial dilution method | 2017 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1 | Synthesis and bioactivity evaluation of 2,3-diaryl acrylonitrile derivatives as potential anticancer agents. |
| AID1339465 | Activation of Nrf2 (unknown origin) expressed in human HepG2 cells after 5 hrs by ARE-driven luciferase reporter gene assay | 2017 | Bioorganic & medicinal chemistry, 02-15, Volume: 25, Issue:4 | Activation of anti-oxidant Nrf2 signaling by substituted trans stilbenes. |
| AID1298430 | Antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as Pol mutation at 50 uM incubated for 4 hrs prior to infection measured at 72 hrs post infection by illumina sequencing method (Rvb = 18.5%) | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID667233 | Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents. |
| AID724578 | Binding affinity to planer lipid bilayer assessed as reduction in diameter of semicircle pattern at up to 60 uM by admittance spectroscopic analysis | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Dose-dependent interaction of trans-resveratrol with biomembranes: effects on antioxidant property. |
| AID1062138 | Antibiofilm activity against Escherichia coli O157:H7 assessed as repression of csgB expression at 20 ug/ml after 5 hrs by qRT-PCR analysis | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1 | Resveratrol oligomers inhibit biofilm formation of Escherichia coli O157:H7 and Pseudomonas aeruginosa. |
| AID1399537 | Binding affinity to amyloid beta (1 to 42) (unknown origin) by surface plasmon resonance assay | 2018 | Bioorganic & medicinal chemistry, 09-01, Volume: 26, Issue:16 | Synthesis and evaluation of 1,2,3,4-tetrahydro-1-acridone analogues as potential dual inhibitors for amyloid-beta and tau aggregation. |
| AID1362749 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-12 production by measuring IL-12 levels incubated with LPS for 1 hr followed by compound addition measured after 48 hrs by ELISA (Rvb = 4839.2 +/- 2.2 pg/ml) | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues. |
| AID1418632 | Disaggregation of Fe3+-induced amyloid beta (1 to 42) (unknown origin) preformed fibrils at 75 uM after 24 hrs by uranyl acetate staining based transmission electron microscopic analysis | 2018 | Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22 | Resveratrol-maltol hybrids as multi-target-directed agents for Alzheimer's disease. |
| AID226690 | Free radical scavenging activity of DPPH was determined; value taken from reference 11 | 2004 | Bioorganic & medicinal chemistry letters, Jan-19, Volume: 14, Issue:2 | Syntheses and radical scavenging activities of resveratrol derivatives. |
| AID331054 | Activation of human SIRT1-H (240-664) construct by mass spectrometry assay relative to control | 2007 | Nature, Nov-29, Volume: 450, Issue:7170 | Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. |
| AID359182 | Inhibition of [14C]dehydroascorbic acid uptake in human U937 cells by scintillation spectrometry in presence of buffer containing NaCl and Na2HPO4 | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3 | Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells. |
| AID359544 | Effect on vascular endothelial growth factor A gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID719280 | Inhibition of mushroom tyrosinase using L-tyrosine as substrate at 0.5 uM after 30 mins by spectrophotometric analysis | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis of novel azo-resveratrol, azo-oxyresveratrol and their derivatives as potent tyrosinase inhibitors. |
| AID1210977 | Bioavailability in C57BL/6 mouse at 15 mg/kg, iv | 2013 | Drug metabolism and disposition: the biological fate of chemicals, May, Volume: 41, Issue:5 | Pulmonary metabolism of resveratrol: in vitro and in vivo evidence. |
| AID432168 | Inhibition of phagocytosis of FITC-conjugated Staphylococcus aureus 209P in mouse RAW264.7 cells using trypan blue staining after 60 mins by flow cytometry | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID359325 | Effect on procollagen 14alpha 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1272524 | Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as induction of intracellular calcium level relative to allyl isothiocyanate | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | TRPA1 channels as targets for resveratrol and related stilbenoids. |
| AID359055 | Reversal of increase in Src kinase phosphorylation in mouse MC3T3-E1 cells at 1 uM in presence of PP2 | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID502077 | Inhibition of human carbonic anhydrase 9 after 15 mins by stopped flow CO2 hydration method | 2010 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17 | Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. |
| AID1884068 | Antibacterial activity against Clostridium tetani CECT 4629 incubated for 24 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID1352511 | Neuroprotective activity in C57BL/6 mouse assessed as decrease in 3-NP-induced p53 expression at 5.5 mg/kg, ip administered for 5 days by qRT-PCR analysis | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Alkylated resveratrol prodrugs and metabolites as potential therapeutics for neurodegenerative diseases. |
| AID501910 | Inhibition of human carbonic anhydrase 7 after 15 mins by stopped flow CO2 hydration method | 2010 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17 | Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. |
| AID1632229 | Cytotoxicity against human DU145 cells assessed as inhibition of cell viability at 2 to 500 uM after 24 hrs in presence of CAT by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18 | Synthesis and anticancer activity of a hydroxytolan series. |
| AID333442 | Effect on COX1 activity in sheep seminal vesicle at 5 uM by TMPD peroxidase assay | 2004 | Journal of natural products, Nov, Volume: 67, Issue:11 | Mechanism-based inactivation of COX-1 by red wine m-hydroquinones: a structure-activity relationship study. |
| AID1826672 | Displacement of 2-[125l]-lodomelatonin from QR2 in hamster brain homogenate by radioligand binding assay | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades. |
| AID404417 | Spasmolytic activity in guinea pig terminal ilea | 2008 | Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11 | Benzanilides with spasmolytic activity: chemistry, pharmacology, and SAR. |
| AID440570 | Increase in mitochondrial function in mouse C2C12 cells assessed as enhancement of mitochondrial density at 50 uM after 16 hrs by green FM dye straining-based fluorescence assay | 2009 | Journal of medicinal chemistry, Sep-10, Volume: 52, Issue:17 | Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors. |
| AID639329 | Antibacterial activity against CagA-expressing Helicobacter pylori 10Kb isolated from gastric carcinoma patient after 24 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1485914 | Antioxidant activity assessed as trolox equivalent of APPH-induced radical scavenging activity at 1 to 10 uM preincubated for 15 mins followed by AAPH addition measured every minute for 120 mins by ORAC fluorescein assay | 2017 | Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14 | Synthesis and pharmacological evaluation of novel chromone derivatives as balanced multifunctional agents against Alzheimer's disease. |
| AID713105 | Inhibition of mushroom tyrosinase-mediated L-tyrosine oxidation at 100 uM after 60 mins by HPLC analysis | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID331043 | Activation of SIRT1 in human U2OS cells assessed as decrease in p53 deacetylation level at 100 uM | 2007 | Nature, Nov-29, Volume: 450, Issue:7170 | Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. |
| AID1534715 | Antioxidant activity assessed as ABTS radical cation scavenging activity by measuring trolox equivalents after 150 mins | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease. |
| AID40024 | In vitro growth inhibition of BXPC-3 (human pancreatic adenocarcinoma) cell line. | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID738176 | Inhibition of Wnt signaling pathway in human HeLa cells assessed as measured as lowest concentration required 50 to 60 % inhibition of Wnt3a induced luciferase treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID347335 | Activation of human SIRT1 expressed in Escherichia coli BL21Start assessed as concentration required to increase 50% enzyme activity by mass spectrometry assay | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5 | Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators. |
| AID726360 | Antioxidant activity against CCl4-induced oxidative hepatic injury Wistar albino rat model assessed as effect on liver cytosolic GSH-Px activity per mg protein at 100 mg/kg, ip for 7 consecutive days prior to CCL4 challenge measured 24 hrs post CCl4 chall | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Antioxidant activities of thiosemicarbazones from substituted benzaldehydes and N-(tetra-O-acetyl-β-D-galactopyranosyl)thiosemicarbazide. |
| AID1608175 | Binding affinity to Keap1 in rat HBZY-1 cells assessed as induction of Keap1/Nrf2 signaling by measuring increase in GCLC mRNA expression at 6 uM by RT-PCR analysis | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Synthesis and assessment of phenylacrylamide derivatives as potential anti-oxidant and anti-inflammatory agents. |
| AID378353 | Inhibition of phorbol ester-induced ornithine decarboxylase in human MCF7 cells after 6 hrs | 1999 | Journal of natural products, Feb, Volume: 62, Issue:2 | New bioactive flavonoids and stilbenes in cubé resin insecticide. |
| AID475504 | Binding affinity to amyloid beta (1 to 42) fibrils by change in fluorescence at 100 uM after 10 mins | 2009 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17 | A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta. |
| AID468424 | AUC in intragastrically dosed rat assessed as resveratrol level at 0.09 mmol/kg after 10 mins | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | Soluble polyphenols: synthesis and bioavailability of 3,4',5-tri(alpha-D-glucose-3-O-succinyl) resveratrol. |
| AID1168374 | Hepatoprotective activity against isoniazid-rifampicin induced liver injury in BALB/c mouse assessed as effect on nicotinamide phosphoribosyltransferase mRNA level at 100 mg/kg, po bid for 3 days starting 30 mins prior isoniazid-rifampicin administration | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. |
| AID1372034 | Antioxidant activity assessed as rate constant for singlet oxygen scavenging activity in methanol solution by EPR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID416979 | Induction of apoptosis in human HL60 cells assessed as cell accumulation at sub-G1 phase at 150 uM after 48 hrs by propidium iodide staining based flow cytometry | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7 | Antioxidant-based lead discovery for cancer chemoprevention: the case of resveratrol. |
| AID1418633 | Disaggregation of Cu2+-induced amyloid beta (1 to 42) (unknown origin) preformed fibrils at 50 uM after 24 hrs by uranyl acetate staining based transmission electron microscopic analysis | 2018 | Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22 | Resveratrol-maltol hybrids as multi-target-directed agents for Alzheimer's disease. |
| AID359095 | Inhibition of etoposide-induced apoptosis in rat primary osteoblast cells after 24 hrs by flow cytometry | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1298396 | Reduction in dCTP level in human U373-MAGI cells at 50 uM preincubated for 2 hrs followed by 5-aza-dC addition measured after 4 hrs by LC-MS/MS analysis relative to 5-aza-dC | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID667230 | Cytotoxicity against human A2780 cells after 96 hrs by SRB assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents. |
| AID395150 | ABTS radical scavenging activity assessed as Trolox equivalent antioxidant capacity | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | QSAR study of antioxidant activity of wine polyphenols. |
| AID416674 | Cytotoxicity against human HCT8 cells after 72 hrs by MTT assay | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Synthesis and biological evaluation of cytotoxic properties of stilbene-based resveratrol analogs. |
| AID634529 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha production at 50 uM after 1.5 hrs by ELISA | 2011 | Bioorganic & medicinal chemistry, Dec-15, Volume: 19, Issue:24 | Synthesis and study of new paramagnetic resveratrol analogues. |
| AID271285 | Selectivity index, IC50 for COX1/IC50 for COX2 in human whole blood | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17 | Selective COX-2 inhibitors. Part 1: synthesis and biological evaluation of phenylazobenzenesulfonamides. |
| AID1298349 | Antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as increase in frequency of A to C transversion at 50 uM incubated for 4 hrs prior to infection measured at 72 hrs post infection by illumina sequencing me | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1314125 | Toxicity in rat thymocytes assessed as increase in cell death at 1 uM measured after 4 hrs by flow cytometric analysis relative to control | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | A facile and rapid access to resveratrol derivatives and their radioprotective activity. |
| AID549844 | Agonist activity at human ERbeta receptor expressed in human HEK293 cells co-expressing ERE assessed as increase of estradiol-induced luciferase gene expression at 1 uM after 18 hrs relative to estradiol | 2011 | Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1 | New hydroxystilbenoid derivatives endowed with neuroprotective activity and devoid of interference with estrogen and aryl hydrocarbon receptor-mediated transcription. |
| AID1178157 | Antioxidant activity of the compound assessed as reduction in absorbance of DPPH after 60 mins incubation at 300 uM by DPPH radical scavenging /microplate assay | 2014 | Bioorganic & medicinal chemistry, May-01, Volume: 22, Issue:9 | Synthesis, antioxidant and photoprotection activities of hybrid derivatives useful to prevent skin cancer. |
| AID1272523 | Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as induction of intracellular calcium level | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | TRPA1 channels as targets for resveratrol and related stilbenoids. |
| AID1290887 | Inhibition of rat serum butyrylcholinesterase using butyrylthiocholine iodide substrate after 15 mins by spectrophotometric method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Pterostilbene-O-acetamidoalkylbenzylamines derivatives as novel dual inhibitors of cholinesterase with anti-β-amyloid aggregation and antioxidant properties for the treatment of Alzheimer's disease. |
| AID1298435 | Potentiation of 5-Aza-C-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as Pol mutation at 50 uM incubated for 4 hrs preinfection followed by 5-Aza-C addition for 2 hrs preinfection and subsequen | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1365633 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins | 2017 | Bioorganic & medicinal chemistry, 11-01, Volume: 25, Issue:21 | Design, synthesis, and evaluation of salicyladimine derivatives as multitarget-directed ligands against Alzheimer's disease. |
| AID650848 | Inhibition of TNF-alpha activated NF-kappaB expressed in HEK293 cells by luciferase reporter gene assay | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7 | Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol. |
| AID1738184 | Inhibition of HFIP-pretreated human amyloid beta (1 to 42) self aggregation at 10 uM incubated for 36 to 48 hrs by thioflavin-T based fluorescence method relative to control | |||
| AID1780359 | Activation of recombinant human SIRT3 assessed as lysyl deacetylase activity using (Gln-Pro-Lys-Lys(Ac)) peptide substrate by fluorescent assay | |||
| AID1628088 | Activation of SIRT1 in human HaCaT cell nuclear extract at 1 uM by fluorimetric assay | 2016 | Journal of medicinal chemistry, Feb-25, Volume: 59, Issue:4 | 1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells. |
| AID1662436 | Inhibition of human DNA polymerase-alpha (unknown origin) | 2020 | Journal of medicinal chemistry, 09-24, Volume: 63, Issue:18 | p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators. |
| AID1298369 | Increase of 5-Aza-C-mediated cytotoxicity against human U373-MAGI cells at 50 uM preincubated for 2 hrs followed by 5-Aza-C addition for 2 hrs measured after 72 hrs by Celltiter-Glo luminescent cell viability assay (Rvb = 387 uM) | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID455034 | Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay | 2009 | Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18 | E-Combretastatin and E-resveratrol structural modifications: antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes. |
| AID1570237 | Inhibition of 5-LOX in human PMNL cells assessed as A23187-stimulated LTB4 production preincubated for 15 mins followed by A23187 addition and measured after 10 mins by HPLC analysis | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors. |
| AID1311764 | Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as IL1beta levels at 25 umol/L by ELISA (Rvb = 8.70 +/- 0.365 pg/mL) | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata. |
| AID375989 | Antioxidant activity assessed as superoxide anion scavenging activity by xanthine oxidase oxidation system relative to control | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4 | Vanillic acid glycoside and quinic acid derivatives from Gardeniae Fructus. |
| AID333440 | Inhibition of cyclooxygenase activity of COX1 in sheep seminal vesicle in presence of 1 mM phenol by cyclooxygenase assay | 2004 | Journal of natural products, Nov, Volume: 67, Issue:11 | Mechanism-based inactivation of COX-1 by red wine m-hydroquinones: a structure-activity relationship study. |
| AID359336 | Effect on epidermal growth factor gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1333790 | Cytotoxicity against human Bel7402 cells assessed as cell growth inhibition at 100 uM after 48 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1 | Synthesis and bioactivity evaluation of 2,3-diaryl acrylonitrile derivatives as potential anticancer agents. |
| AID359329 | Effect on procollagen 1 alpha 2 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID549850 | Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced oxytosis after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1 | New hydroxystilbenoid derivatives endowed with neuroprotective activity and devoid of interference with estrogen and aryl hydrocarbon receptor-mediated transcription. |
| AID1428608 | Binding affinity to Cu2+ assessed as disaggregation of Cu2+-induced amyloid beta (1 to 42) aggregation at 75 uM incubated for 24 hrs under dark condition by uranyl acetate staining based transmission electron microscopic method | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Synthesis and biological evaluation of deferiprone-resveratrol hybrids as antioxidants, Aβ |
| AID481137 | Displacement of FITC-conjugated BH3-Bak peptide from 1 uM Vaccinia virus recombinant N1L expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assay | 2010 | Journal of medicinal chemistry, May-27, Volume: 53, Issue:10 | Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention. |
| AID676662 | Antioxidant activity against ABTS radical assessed as trolox equivalent after 24 hr at pH 7 | 2012 | Journal of natural products, Jun-22, Volume: 75, Issue:6 | Purification and antiradical properties of the structural unit of betalains. |
| AID375988 | Antioxidant activity assessed as DPPH free radical scavenging activity relative to control | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4 | Vanillic acid glycoside and quinic acid derivatives from Gardeniae Fructus. |
| AID359063 | Effect on bone morphogenetic protein 5 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID294477 | Induction of quinone reductase in mouse mutant Hepa 1c1c7c1 cells at 12.5 uM after 24 hrs relative to control | 2007 | European journal of medicinal chemistry, Jun, Volume: 42, Issue:6 | Quinone reductase induction activity of methoxylated analogues of resveratrol. |
| AID416968 | Inhibition of hydrogen peroxide-induced DNA damage in human PBL cells at 12.5 uM by Comet assay | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7 | Antioxidant-based lead discovery for cancer chemoprevention: the case of resveratrol. |
| AID1609878 | Induction of apoptosis in human HuH7 cells overexpressing EGFP at 100 uM incubated for 48 hrs by annexin V and 7-AAD staining based assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Review about the multi-target profile of resveratrol and its implication in the SGK1 inhibition. |
| AID1354541 | Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced IL6 expression after 24 hrs by ELISA | 2018 | Journal of natural products, 05-25, Volume: 81, Issue:5 | Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner. |
| AID359524 | Effect on matrix metalloprotease 2 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID614623 | Binding affinity to recombinant C1 domain of PKCalpha expressed in Escherichia coli BL21 (DE3) after 45 mins by fluorescence quenching assay | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18 | Chemical modifications of resveratrol for improved protein kinase C alpha activity. |
| AID1220764 | Terminal half life in C57BL/6 mouse at 15 mg/kg administered intraarterially by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Oct, Volume: 40, Issue:10 | In vivo-formed versus preformed metabolite kinetics of trans-resveratrol-3-sulfate and trans-resveratrol-3-glucuronide. |
| AID359083 | Increase in osteocalcin levels in human MG63 cells at 1 uM after 72 hrs by ELISA | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID258724 | Inhibition of thrombin-induced platelet aggregation in human | 2006 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 16, Issue:2 | Design, synthesis, and vasorelaxant and platelet antiaggregatory activities of coumarin-resveratrol hybrids. |
| AID377457 | Estrogenic activity in human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol by alamar blue assay | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3 | Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines. |
| AID1362656 | Disaggregation of self-induced amyloid beta (1 to 40) (unknown origin) preformed fibrils assessed as fluorescence emission at 100 uM after 12 days by thioflavin-T based assay (Rvb = 375.63 +/- 8.38 No_unit) | |||
| AID1281396 | Inhibition of human recombinant NQO2 using DCPIPas substrate and NRH as cofactor measured for 1 min by spectrophotometry in the absence of BSA | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Non-symmetrical furan-amidines as novel leads for the treatment of cancer and malaria. |
| AID359307 | Effect on bone morphogenetic protein 8a gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1879007 | Inhibition of apoptosis in CCL-4 induced liver fibrosis C57/B6J mouse model transfected with miR-190a-5p agomir at 100 mg/kg/day, ip measured after 72 hrs post last dose | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID416969 | Prooxidant activity assessed as induction calf thymus DNA damage in presence of 250 uM Cu(II) by ethidium bromide binding based fluorimetric assay | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7 | Antioxidant-based lead discovery for cancer chemoprevention: the case of resveratrol. |
| AID359292 | Decrease in Akt activation in human MDA-MB-231 cells expressing FOXO3a-specific small interfering RNA xenografted in nude mice at 10 mg/kg for 2 days | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1298415 | Potentiation of 5-Aza-dC-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as reduction in U5-gag level at 50 uM after 2 to 72 hrs by qPCR method | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1391153 | Inhibition of recombinant human NQO2 assessed as change in rate of decolouration of DCPIP measured over 1 min by spectrophotometric method | 2018 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 28, Issue:8 | Evaluation of analogues of furan-amidines as inhibitors of NQO2. |
| AID1420921 | Antibacterial activity against Salmonella typhimurium after 17 hrs by NCCLS broth microdilution method | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Antibacterial and antioxidant activities for natural and synthetic dual-active compounds. |
| AID716917 | Inhibition of mushroom tyrosinase assessed as L-DOPA oxidation at 100 uM incubated 30 mins prior to substrate addition measured after 60 mins by UV-vis spectrophotometric analysis | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID1210978 | Drug metabolism in mouse lung S9 fractions assessed as trans-resveratrol-3-O-glucuronide formation preincubated for 3 mins followed by UDPGA addition measured after 60 mins by Eadie-Hofstee plot analysis | 2013 | Drug metabolism and disposition: the biological fate of chemicals, May, Volume: 41, Issue:5 | Pulmonary metabolism of resveratrol: in vitro and in vivo evidence. |
| AID359306 | Effect on bone morphogenetic protein 7 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID510868 | Cytotoxicity against human HT-29 cells after 3 days by [3H]thymidine incorporation assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer. |
| AID1351440 | Reduction in tumor cell proliferation in colorectal cancer patient at 0.5 to 1 g/day, po administered 8 times per day for 8 days by Ki-67 staining-based microscopic method relative to control | 2018 | European journal of medicinal chemistry, Jan-20, Volume: 144 | Natural compounds and combination therapy in colorectal cancer treatment. |
| AID638154 | Bactericidal activity against CagA-expressing Helicobacter pylori MD6 isolated from chronic gastritis patient compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1609870 | Induction of apoptosis in human HuH7 cells assessed as increase in early apoptotic cells at 100 uM incubated for 48 hrs by annexin V and 7-AAD staining based assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Review about the multi-target profile of resveratrol and its implication in the SGK1 inhibition. |
| AID1298443 | Potentiation of 5-Aza-dC-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as Nef mutation at 50 uM incubated for 4 hrs preinfection followed by 5-Aza-C addition for 2 hrs preinfection and subseque | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID718775 | Antioxidant activity assessed as trolox equivalent of AAPH-induced radical scavenging activity incubated for 10 mins prior to APPH challenge measured every minute for 120 mins by ORAC assay | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Design, synthesis, and evaluation of resveratrol derivatives as Aß(₁-₄₂) aggregation inhibitors, antioxidants, and neuroprotective agents. |
| AID501915 | Inhibition of mouse carbonic anhydrase 15 after 15 mins by stopped flow CO2 hydration method | 2010 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17 | Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. |
| AID359501 | Effect on fibroblast growth factor receptor 3 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1762745 | Antiinflammatory activity against mouse BV2 cells assessed as reduction in LPS-induced NO production at 20 uM incubated for 2 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay relative to control | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | Ximaoglaucumins A - F, new cembranoids with anti-inflammatory activities from the South China Sea soft coral Sarcophyton glaucum. |
| AID1333000 | Antioxidant activity in CCL4-intoxicated Wistar albino rat assessed as liver cytosolic catalase activity per mg protein at 100 mg/kg, ip administered for 7 consecutive days after DL-alpha-tocopherol acetate treatment followed by CCL4 dosing measured after | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and evaluation of in vivo antioxidant, in vitro antibacterial, MRSA and antifungal activity of novel substituted isatin N-(2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyl)thiosemicarbazones. |
| AID460548 | Antiaging effect in Saccharomyces cerevisiae K6001 assessed as extension of replicative life span after 2 days | 2010 | Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3 | Ganodermasides A and B, two novel anti-aging ergosterols from spores of a medicinal mushroom Ganoderma lucidum on yeast via UTH1 gene. |
| AID1826998 | Inhibition of human recombinant NQO2 | |||
| AID1311762 | Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as TNFalpha levels at 50 umol/L by ELISA (Rvb = 183.21 +/- 5.36 pg/mL) | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata. |
| AID491521 | Inhibition of LPS-induced COX2 expression in mouse RAW264.7 cells at 34 uM treated 15 mins before LPS challenge measured after 18 hrs by immunoblotting | 2010 | Journal of medicinal chemistry, Jul-08, Volume: 53, Issue:13 | Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. |
| AID1611501 | Antioxidant activity assessed as DPPH free radical scavenging activity at 300 uM incubated for 60 mins by spectrophotometric method relative to control | 2019 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 29, Issue:24 | Synthesis and evaluation of 1,3,5-triazine derivatives as sunscreens useful to prevent skin cancer. |
| AID654114 | Antioxidant activity assessed as concentration required for 50% DPPH scavenging activity after 30 mins by spectrophotometry | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8 | Free radical scavenging and antiproliferative properties of Biginelli adducts. |
| AID738174 | Inhibition of Hedgehog signaling pathway in human HeLa cells assessed as measured as lowest concentration required 50 to 60 % inhibition of PMA induced luciferase treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID1264958 | Cytotoxicity against human MSC assessed as cell viability at 10 uM treated for 6 days measured on day 7 by alamar blue assay (Rvb = 96 to 101%) | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11 | Defining Key Structural Determinants for the Pro-osteogenic Activity of Flavonoids. |
| AID1059139 | Antiproliferative activity against human A2780 cells after 2 days by Alamar Blue assay | 2013 | Bioorganic & medicinal chemistry, Dec-15, Volume: 21, Issue:24 | Bioactive compounds from Stuhlmannia moavi from the Madagascar dry forest. |
| AID610400 | Antiinflammatory activity in human CCD-18Co cells assessed as inhibition of IL1beta-induced PGE2 production at 2.5 to 25 uM after 18 hrs | 2010 | Journal of medicinal chemistry, Oct-28, Volume: 53, Issue:20 | Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents. |
| AID726361 | Antioxidant activity against CCl4-induced oxidative hepatic injury Wistar albino rat model assessed as effect on liver cytosolic SOD activity per mg protein at 100 mg/kg, ip for 7 consecutive days prior to CCL4 challenge measured 24 hrs post CCl4 challeng | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Antioxidant activities of thiosemicarbazones from substituted benzaldehydes and N-(tetra-O-acetyl-β-D-galactopyranosyl)thiosemicarbazide. |
| AID700046 | Antiviral activity against HIV1 infected in human U373-MAGI cells expressing CXCR4 assessed as frequency of viral mutagenesis at 20 uM preincubated for 2 hrs prior to infection followed by compound wash out measured after 48 hrs by flow cytometry relative | 2012 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 22, Issue:21 | Anti-HIV-1 activity of resveratrol derivatives and synergistic inhibition of HIV-1 by the combination of resveratrol and decitabine. |
| AID359498 | Effect on fibroblast growth factor 3 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID359107 | Increase in BMP2 levels in rat primary osteoblast cells at 1 uM by Western blot | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1436102 | Antioxidant activity assessed as DPPH radical scavenging activity at 50 uM relative to control | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | 2,4-Disubstituted quinazolines as amyloid-β aggregation inhibitors with dual cholinesterase inhibition and antioxidant properties: Development and structure-activity relationship (SAR) studies. |
| AID359539 | Effect on ornithine decarboxylase gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID655170 | Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5 | A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. |
| AID1054210 | Antiviral activity against HIV1 infected in human U373-MAGI cells incubated for 2 hrs prior to viral infection followed by compound washout after 24 hrs measured 72 hrs post-infection by flow cytometry | 2013 | Bioorganic & medicinal chemistry, Nov-15, Volume: 21, Issue:22 | 5,6-Dihydro-5-aza-2'-deoxycytidine potentiates the anti-HIV-1 activity of ribonucleotide reductase inhibitors. |
| AID340408 | Inhibition of LPS-stimulated NO release in rat cortical microglial cells assessed as nitrite accumulation at 10 ug/ml after 48 hrs relative to LPS | 2008 | Journal of natural products, Jul, Volume: 71, Issue:7 | Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia. |
| AID359517 | Effect on MAD homolog 4 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1371381 | Cytotoxicity against human T47D cells assessed as cell viability at 16 uM after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1062136 | Antibiofilm activity against Escherichia coli O157:H7 assessed as repression of csgD expression at 20 ug/ml after 5 hrs by qRT-PCR analysis | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1 | Resveratrol oligomers inhibit biofilm formation of Escherichia coli O157:H7 and Pseudomonas aeruginosa. |
| AID273489 | Suppression of LPS-stimulated COX2 mRNA expression in mouse BV2 cells at 4 uM | 2006 | Journal of medicinal chemistry, Nov-30, Volume: 49, Issue:24 | Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB. |
| AID1309188 | Binding affinity to Cu2+ using CuCl2 after 5 mins by spectrophotometry | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Ionophoric polyphenols selectively bind Cu(2+), display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila. |
| AID642336 | Induction of QR1-mediated cytoprotective activity in mouse BPrc1 cells at 50 uM assessed as cell survival | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets. |
| AID482995 | Inhibition of amyloid beta 25-35 fibril formation by using UV-visible measurements and electron microscopy analysis | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11 | New stilbene dimers against amyloid fibril formation. |
| AID378354 | Cytotoxicity against human MCF7 cells after 72 hrs | 1999 | Journal of natural products, Feb, Volume: 62, Issue:2 | New bioactive flavonoids and stilbenes in cubé resin insecticide. |
| AID359323 | Effect on procollagen 12alpha 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID549847 | Selectivity ratio, ratio of RBA for human recombinant ERbeta to RBA for human recombinant ERalpha | 2011 | Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1 | New hydroxystilbenoid derivatives endowed with neuroprotective activity and devoid of interference with estrogen and aryl hydrocarbon receptor-mediated transcription. |
| AID359505 | Effect on histone H1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1168375 | Hepatoprotective activity against isoniazid-rifampicin induced liver injury in BALB/c mouse assessed as effect on NAD+ concentration at 100 mg/kg, po bid for 3 days starting 30 mins prior isoniazid-rifampicin administration measured 24 hrs post-last dose | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. |
| AID642333 | Induction of QR1-mediated cytoprotective activity in mouse TAOc1 mutant Hepa cells at 50 uM assessed as cell survival | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets. |
| AID1203634 | Antiproliferative activity against human A549 cells assessed as cell viability after 48 hrs by MTT assay | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Design, synthesis, and biological evaluation of benzoselenazole-stilbene hybrids as multi-target-directed anti-cancer agents. |
| AID1609873 | Antiproliferative activity against human HuH7 cells transfected with ShSGK1 assessed as reduction in cell viability at 100 uM incubated for 48 hrs by trypan blue dye based assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Review about the multi-target profile of resveratrol and its implication in the SGK1 inhibition. |
| AID1278607 | Selectivity index ratio of IC50 for ovine COX-1 to IC50 for human recombinant COX-2 | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog. |
| AID1884059 | Antibacterial activity against Enterococcus faecalis LMG 16003 incubated for 20 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID359532 | Effect on serine proteinase inhibitor clade H1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1428607 | Binding affinity to Fe3+ assessed as disaggregation of Fe3+-induced amyloid beta (1 to 42) aggregation at 50 uM incubated for 24 hrs under dark condition by uranyl acetate staining based transmission electron microscopic method | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Synthesis and biological evaluation of deferiprone-resveratrol hybrids as antioxidants, Aβ |
| AID1261077 | Cytotoxicity against human HT-29 cells assessed inhibition of cell proliferation after 2 days by MTT assay | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Inhibitory effect of cytotoxic stilbenes related to resveratrol on the expression of the VEGF, hTERT and c-Myc genes. |
| AID699923 | Selectivity index, ratio of TC50 for human U373-MAGI cells to EC50 for human U373-MAGI cells infected with HIV1 | 2012 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 22, Issue:21 | Anti-HIV-1 activity of resveratrol derivatives and synergistic inhibition of HIV-1 by the combination of resveratrol and decitabine. |
| AID1339466 | Activation of Nrf2 (unknown origin) expressed in human HepG2 cells after 5 hrs by ARE-driven luciferase reporter gene assay relative to control | 2017 | Bioorganic & medicinal chemistry, 02-15, Volume: 25, Issue:4 | Activation of anti-oxidant Nrf2 signaling by substituted trans stilbenes. |
| AID1566056 | Cytotoxicity against human SKOV3 cells transfected with non-targeted vector assessed as reduction in cell viability incubated for 96 hrs in presence of doxycycline by MTT assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2). |
| AID762888 | Effect on PAI-1 expression in H2O2-induced HUVEC pretreated for 1 day followed by compound washout and H2O2-treatment measured after 10 days by immunoblotting analysis | 2013 | Journal of natural products, Jul-26, Volume: 76, Issue:7 | trans-Resveratrol in Gnetum gnemon protects against oxidative-stress-induced endothelial senescence. |
| AID416719 | Toxicity in mouse erythrocytes assessed as hemolysis at 1.5 to 200 ug/mL after 30 min by spectrophotometry | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Synthesis and biological evaluation of cytotoxic properties of stilbene-based resveratrol analogs. |
| AID1430675 | Cmax in CD rat at 50 mg/kg/day, po administered via gavage every 24 hrs for 14 consecutive days measured on day 1 post dose by HPLC-MS analysis | 2017 | ACS medicinal chemistry letters, May-11, Volume: 8, Issue:5 | Toward Resolving the Resveratrol Conundrum: Synthesis and |
| AID642328 | Induction of QR1 activity in mouse Hepa-1c1c7 cells using MTT as substrate assessed as induction ratio by spectrophotometry relative to control | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets. |
| AID1609869 | Antiproliferative activity against human HuH7 cells assessed as reduction in cell viability at 100 uM incubated for 48 hrs by trypan blue dye based assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Review about the multi-target profile of resveratrol and its implication in the SGK1 inhibition. |
| AID1261100 | Down regulation of hTERT gene expression in human MCF7 cells at 10 ug/mL after 48 hrs by RT-qPCR analysis relative to control | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Inhibitory effect of cytotoxic stilbenes related to resveratrol on the expression of the VEGF, hTERT and c-Myc genes. |
| AID206620 | The minimum inhibitory concentration (MIC) that inhibits all visible growth of the Staphylococcus aureus (bacteria) at 64 ug/ml | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID638050 | Antibacterial activity against CagA-expressing Helicobacter pylori G20 isolated from chronic gastritis patient after 48 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1333795 | Antibacterial activity Pseudomonas aeruginosa 2742 at 64 ug/ml after 24 hrs by serial dilution method | 2017 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1 | Synthesis and bioactivity evaluation of 2,3-diaryl acrylonitrile derivatives as potential anticancer agents. |
| AID1609866 | Inhibition of SGK1 in human HUH7 cells at 100 uM using peptide as substrate incubated for 6 hrs by scintillation counter method | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Review about the multi-target profile of resveratrol and its implication in the SGK1 inhibition. |
| AID1298437 | Potentiation of 5-Aza-C-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as Env mutation at 50 uM incubated for 4 hrs preinfection followed by 5-Aza-C addition for 2 hrs preinfection and subsequen | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID650850 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 30 mins measured 24 hrs post LPS challenge by Griess method | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7 | Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol. |
| AID1452015 | Inhibition human wild type TTR expressed in Escherichia coli BL-21 assessed as fibril formation at 14.4 uM incubated for 30 mins after 96 hrs by light scattering method relative to control | 2017 | Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18 | Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation. |
| AID359542 | Effect on vascular cell adhesion molecule 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1379011 | Inhibition of equine serum BChE using S-butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured up to 180 secs by spectrophotometric analysis | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease. |
| AID1210974 | Volume of distribution at steady state in C57BL/6 mouse at 15 mg/kg, iv | 2013 | Drug metabolism and disposition: the biological fate of chemicals, May, Volume: 41, Issue:5 | Pulmonary metabolism of resveratrol: in vitro and in vivo evidence. |
| AID359061 | Reversal of increase in ER.DNA complex in rat primary osteoblast cells transfected with dominant-negative mutant Src expression vector at 1 uM by RT-PCR | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID610300 | Increase in Bifidobacterial count in C57BL/6J mouse distal colon mucosa with DSS-induced colon inflammation at 2.1 mg/kg/day, po for 21 days followed by compound dosing for 8 days co-administered with DSS followed by 2.1 mg/kg/day, po dosing for 6 days in | 2010 | Journal of medicinal chemistry, Oct-28, Volume: 53, Issue:20 | Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents. |
| AID57707 | In vitro growth inhibition of DU-145 (human prostate carcinoma) cell line. | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID1264951 | Cytotoxicity against human MSC assessed as cell viability at 5 uM measured on day 1 by alamar blue assay (Rvb = 97 to 101%) | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11 | Defining Key Structural Determinants for the Pro-osteogenic Activity of Flavonoids. |
| AID1314128 | Toxicity in rat thymocytes assessed as increase in cell death at 1000 uM measured after 4 hrs by flow cytometric analysis relative to control | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | A facile and rapid access to resveratrol derivatives and their radioprotective activity. |
| AID1879013 | Upregulation of Bcl-2 protein expression in TGF-beta1 induced C57/B6J mouse primary hepatocytes in presence of miR-190a-5p mimic by Western blot analysis | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID724571 | Induction of budding morphology in human erythrocytes up to 100 uM after 1 hr by cold field emission scanning electron microscopic analysis | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Dose-dependent interaction of trans-resveratrol with biomembranes: effects on antioxidant property. |
| AID1878982 | Inhibition of TGF-beta1 induced apoptosis in C57/B6J mouse primary hepatocytes assessed as live cells at 10 uM by Annexin-V-FITC-H and PI staining based flow cytometry analysis (Rvb = 66.08 %) | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID1418626 | Metal chelating activity assessed as inhibition of Cu2+-induced amyloid beta (1 to 42 residues) fibrils at 50 uM after 24 hrs by uranyl acetate staining based transmission electron microscopic analysis | 2018 | Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22 | Resveratrol-maltol hybrids as multi-target-directed agents for Alzheimer's disease. |
| AID1290889 | Antioxidant activity assessed as AAPH scavenging activity assessed as trolox equivalent after 15 mins measured every min for 90 mins by ORAC-FL method relative to control trolox | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Pterostilbene-O-acetamidoalkylbenzylamines derivatives as novel dual inhibitors of cholinesterase with anti-β-amyloid aggregation and antioxidant properties for the treatment of Alzheimer's disease. |
| AID1203633 | Antiproliferative activity against human Bel7402 cells assessed as cell viability after 48 hrs by MTT assay | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Design, synthesis, and biological evaluation of benzoselenazole-stilbene hybrids as multi-target-directed anti-cancer agents. |
| AID1879022 | Antifibrotic activity in CCL-4 induced liver fibrosis C57/B6J mouse model assessed as reduction in miR-190a-5p expression in liver at 100 mg/kg/day, ip measured after 72 hrs post last dose by qRT-PCR analysis | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID730564 | Antinociceptive activity in Swiss mouse assessed as inhibition of glutamate-induced spontaneous nociception at 300 ug/site, administered as intrathecally | 2013 | Journal of natural products, Jan-25, Volume: 76, Issue:1 | Evidence for the analgesic activity of resveratrol in acute models of nociception in mice. |
| AID1519077 | Antimelanogenic activity against C57BL/6 mouse B16F10 cells incubated for 72 hrs | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | From bench to counter: Discovery and validation of a peony extract as tyrosinase inhibiting cosmeceutical. |
| AID359511 | Effect on integrin alpha M gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1203662 | Induction of apoptosis in human Bel7402 cells assessed as necrotic cells at 50 uM after 48 hrs by flow cytometry (Rvb = 0.19%) | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Design, synthesis, and biological evaluation of benzoselenazole-stilbene hybrids as multi-target-directed anti-cancer agents. |
| AID1878981 | Downregulation of miR-190a-5p expression in TGF-beta induced human HepG2 cells at 10 to 50 uM incubated for 4 hrs by qRT-PCR analysis | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID359299 | Inhibition of induction of ALP activity in mouse MC3T3-E1 cells at 1 uM after 48 hrs in presence of BMP2-specific neutralizing antibody | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1825234 | Activation of SIRT1 (unknown origin) expressed in human HEK293 cells assessed as decrease in luciferase activity at 20 uM measured after 24 hrs by luciferase reporter gene assay | |||
| AID359176 | Inhibition of 2-[1,2-3H(N)]deoxy-D-glucose uptake in human U937 cells by scintillation spectrometry in presence of sodium-free buffer | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3 | Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells. |
| AID749799 | Antiproliferative activity against human HT-29 cells after 3 days by MTT assay | 2013 | Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11 | Inhibition of VEGF expression in cancer cells and endothelial cell differentiation by synthetic stilbene derivatives. |
| AID381193 | Antioxidant activity against copper-induced lipid peroxidation in human LDL after 1 hr relative to probucol | 1999 | Journal of natural products, Sep, Volume: 62, Issue:9 | Antioxidant principles from Ephemerantha lonchophylla. |
| AID265508 | Apoptosis inducing activity in human HL60 cells | 2006 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 16, Issue:12 | Stilbene-based anticancer agents: resveratrol analogues active toward HL60 leukemic cells with a non-specific phase mechanism. |
| AID1188903 | Inhibition of recombinant firefly luciferase at 0.0001 to 100 uM by absorption spectroscopy in presence of varying concentration of ATP | 2014 | ACS medicinal chemistry letters, Aug-14, Volume: 5, Issue:8 | Total Synthesis and Biological Studies of TMC-205 and Analogues as Anticancer Agents and Activators of SV40 Promoter. |
| AID719284 | Inhibition of mushroom tyrosinase using L-tyrosine as substrate at 5 uM after 30 mins by spectrophotometric analysis | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis of novel azo-resveratrol, azo-oxyresveratrol and their derivatives as potent tyrosinase inhibitors. |
| AID359316 | Effect on procollagen 7 alpha 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1878988 | Inhibition of TGF-beta1 induced apoptosis in C57/B6J mouse primary hepatocytes assessed as late apoptotic cells at 25 uM by Annexin-V-FITC-H and PI staining based flow cytometry analysis (Rvb = 12.12 %) | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID1882446 | Inhibition of HDAC6 derived from human HeLa cell nuclear extract at 100 uM incubated for 2 hrs relative to control | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4 | Chasing a Breath of Fresh Air in Cystic Fibrosis (CF): Therapeutic Potential of Selective HDAC6 Inhibitors to Tackle Multiple Pathways in CF Pathophysiology. |
| AID49102 | The minimum inhibitory concentration (MIC) that inhibits all visible growth of the Candida albicans (fungus) at 64 ug/ml | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID716921 | Antimelanogenic activity in mouse assessed as cellular melanin content B16F10 cells after 72 hrs by spectrophotometric analysis | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID1872723 | Inhibition of HFIP-treated Amyloid beta (1 to 42) (unknown origin) self aggregation at 20 uM incubated for 46 to 48 hrs by fluorescence based assay relative to control | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy. |
| AID1608146 | Binding affinity to Keap1 in rat HBZY-1 cells assessed as induction of Keap1/Nrf2 signaling by measuring increase in HO-1 protein expression by Western blot analysis | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Synthesis and assessment of phenylacrylamide derivatives as potential anti-oxidant and anti-inflammatory agents. |
| AID1178159 | Antioxidant activity of the compound assessed as reduction in absorbance of DPPH after 60 mins incubation at 35 uM by DPPH radical scavenging /microplate assay | 2014 | Bioorganic & medicinal chemistry, May-01, Volume: 22, Issue:9 | Synthesis, antioxidant and photoprotection activities of hybrid derivatives useful to prevent skin cancer. |
| AID614621 | Inhibition of membrane translocation of PKCalpha expressed in HEK293 cells at 100 uM after 2 hrs by Western blotting | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18 | Chemical modifications of resveratrol for improved protein kinase C alpha activity. |
| AID458153 | Antimicrobial activity against Streptococcus sanguinis NCTC 9811 assessed as total bacterial adherence inhibition | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | The antimicrobial activity of compounds from the leaf and stem of Vitis amurensis against two oral pathogens. |
| AID1467683 | Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx at 30 uM preincubated for 6 mins followed by AITC addition measured for 1 min by Fluo-4 dye-based assay relative to control | 2017 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14 | Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor. |
| AID1418625 | Antioxidant activity assessed as ABTS radical scavenging activity incubated for 10 mins in dark | 2018 | Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22 | Resveratrol-maltol hybrids as multi-target-directed agents for Alzheimer's disease. |
| AID724373 | Antioxidant activity in planer lipid bilayer membrane assessed as inhibition of DPPH-induced reduction in height of semicircle at 50 to 100 uM by admittance spectroscopic analysis | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Dose-dependent interaction of trans-resveratrol with biomembranes: effects on antioxidant property. |
| AID735992 | Neuroprotective activity in human SH-SY5Y cells assessed as inhibition of paraquat-induced cell death at 10 uM incubated for 2 hrs prior to paraquat challenge measured after 24 hrs by MTT assay (Rvb = 62.05 +/- 0.47%) | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis and biological evaluation of novel neuroprotective agents for paraquat-induced apoptosis in human neuronal SH-SY5Y cells. |
| AID639241 | Antibacterial activity against CagA-deficient Helicobacter pylori G104 isolated from chronic gastritis patient after 24 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1065386 | Antimicrobial activity against Staphylococcus aureus A170 after 24 hrs by microbroth dilution method | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Small azobenzene derivatives active against bacteria and fungi. |
| AID1372028 | Antioxidant activity assessed as relative scavenging rate constant for photolysis-induced peroxyl scavenging activity by measuring Kaox/Kst ratio using CYPMPO spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID1878990 | Inhibition of TGF-beta1 induced apoptosis in C57/B6J mouse primary hepatocytes assessed as live cells at 50 uM by Annexin-V-FITC-H and PI staining based flow cytometry analysis (Rvb = 66.08 %) | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID1237126 | Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL6 production at 10 mM pre-incubated for 10 mins before LPS stimulation for 24 hrs by ELISA method | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15 | Design, synthesis and biological evaluation of paralleled Aza resveratrol-chalcone compounds as potential anti-inflammatory agents for the treatment of acute lung injury. |
| AID1272520 | Antagonist activity at rat TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced increase of intracellular calcium level | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | TRPA1 channels as targets for resveratrol and related stilbenoids. |
| AID767376 | Inhibition of amyloid beta (1-42) (unknown origin) aggregation at 20 uM after 48 hrs by thioflavin-T based fluorimetric assay relative to control | 2013 | Bioorganic & medicinal chemistry, Sep-15, Volume: 21, Issue:18 | Synthesis and biological evaluation of berberine-thiophenyl hybrids as multi-functional agents: Inhibition of acetylcholinesterase, butyrylcholinesterase, and Aβ aggregation and antioxidant activity. |
| AID1566052 | Inhibition of recombinant human NQO2 expressed in Escherichia coli using DCPIP as substrate by spectrophotometry | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2). |
| AID1062126 | Antibiofilm activity against Pseudomonas aeruginosa PA14 after 24 hrs by spectrophotometry | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1 | Resveratrol oligomers inhibit biofilm formation of Escherichia coli O157:H7 and Pseudomonas aeruginosa. |
| AID463401 | Antioxidant activity assessed as concentration required to double citronellal oxidation half life by thermo-oxidation method relative to control | 2010 | European journal of medicinal chemistry, Mar, Volume: 45, Issue:3 | A theoretical study of the structure-radical scavenging activity of trans-resveratrol analogues and cis-resveratrol in gas phase and water environment. |
| AID639242 | Antibacterial activity against CagA-deficient Helicobacter pylori Ba142 isolated from chronic gastritis patient after 24 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID724577 | Binding affinity to planer lipid bilayer assessed as change in diameter of semicircle pattern by admittance spectroscopic analysis | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Dose-dependent interaction of trans-resveratrol with biomembranes: effects on antioxidant property. |
| AID1879019 | Antifibrotic activity in CCL-4 induced liver fibrosis C57/B6J mouse model assessed as reduction in COL1A1 mRNA expression at 100 mg/kg/day, ip measured after 72 hrs post last dose by qRT-PCR analysis | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID359327 | Effect on procollagen 18alpha 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID611404 | Cytoprotectant activity against L-buthionine-(S,R)-sulfoximine-induced cell death in Friedreich ataxia patient fibroblasts assessed as increase of cell viability | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. |
| AID713102 | Inhibition of mushroom tyrosinase-mediated L-DOPA oxidation at 100 uM after 30 mins by UV-vis spectrophotometric analysis | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID359081 | Increase in osteocalcin mRNA levels in rat primary osteoblast cells at 1 uM after 72 hrs by RT-PCR | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID738204 | Cytotoxicity against human BT549 cells assessed as growth inhibition measured at 100 uM after 48 hrs by XTT assay | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID1311771 | Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as NO levels at 50 umol/L by ELISA (Rvb = 0.95 +/- 0.052 umol/mL) | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata. |
| AID359555 | Inhibition of induction of ALP activity in rat primary osteoblast cells at 1 uM after 48 hrs in presence of noggin | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1450152 | Growth inhibition of HEK293 cells after 2 days by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11 | One drug for two targets: Biological evaluation of antiretroviral agents endowed with antiproliferative activity. |
| AID423592 | Antioxidant activity assessed as DPPH radical scavenging activity after 5 mins | 2009 | Journal of natural products, Apr, Volume: 72, Issue:4 | Dihydrostilbene derivatives from the Mongolian medicinal plant Scorzonera radiata. |
| AID434724 | Antioxidant activity assessed as DPPH radical scavenging activity at 50 uM | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Synthesis of novel trans-stilbene derivatives and evaluation of their potent antioxidant and neuroprotective effects. |
| AID1225532 | Reduction in Bcl2 to Bax ratio in prostate tissue in BPH-induced Sprague-Dawley rat model at 1 mg/kg, ip daily for 4 weeks by Western blot analysis | 2015 | Journal of natural products, Apr-24, Volume: 78, Issue:4 | Effects of resveratrol on benign prostatic hyperplasia by the regulation of inflammatory and apoptotic proteins. |
| AID331050 | Activation of human SIRT1-D (219-664) construct by mass spectrometry assay relative to control | 2007 | Nature, Nov-29, Volume: 450, Issue:7170 | Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. |
| AID359553 | Inhibition of induction of ALP activity in rat primary osteoblast cells at 1 uM after 48 hrs in presence of BMP2-specific neutralizing antibody | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1060582 | Neuroprotective activity in human SH-SY5Y cells assessed as inhibition H2O2-induced reduction of cell viability at 10 uM after 24 hrs by phase-contrast micrograph analysis | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Design, synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer's disease. |
| AID1362655 | Disaggregation of self-induced amyloid beta (1 to 40) (unknown origin) preformed fibrils assessed as aggregation level at 100 uM after 4 days by UV-visible turbidity method (Rvb = 126.49 +/- 6.93%) | |||
| AID1383208 | Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced TNFalpha production after 24 hrs by ELISA | 2018 | European journal of medicinal chemistry, Apr-10, Volume: 149 | Design, synthesis, and biological evaluation of compounds with a new scaffold as anti-neuroinflammatory agents for the treatment of Alzheimer's disease. |
| AID639240 | Antibacterial activity against CagA-deficient Helicobacter pylori G21b isolated from chronic gastritis patient after 24 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1362657 | Disaggregation of self-induced amyloid beta (1 to 40) (unknown origin) preformed fibrils assessed as aggregation level at 100 uM after 12 days by UV-visible turbidity method (Rvb = 147.12 +/- 3.28%) | |||
| AID432137 | Inhibition of phagocytosis of FITC-conjugated Escherichia coli K12 in human THP1 cells using trypan blue staining after 40 mins by flow cytometry | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID1385433 | Inhibition of NFkappaB in mouse RAW 264.7 cells assessed as reduction in LPS induced NO production after 24 hrs by Griess assay | 2018 | Journal of medicinal chemistry, 09-27, Volume: 61, Issue:18 | Novel Hybrid Conjugates with Dual Suppression of Estrogenic and Inflammatory Activities Display Significantly Improved Potency against Breast Cancer. |
| AID1261704 | Inhibition of human PDE4D using 3H-cAMP as substrate after 15 mins by liquid scintillation counting analysis | 2015 | Journal of medicinal chemistry, Nov-12, Volume: 58, Issue:21 | Design, Synthesis, and Evaluation of Orally Available Clioquinol-Moracin M Hybrids as Multitarget-Directed Ligands for Cognitive Improvement in a Rat Model of Neurodegeneration in Alzheimer's Disease. |
| AID478954 | Induction of apoptosis in human H460 cells at 10 to 20 uM after 72 hrs by TUNEL assay | 2010 | Bioorganic & medicinal chemistry, May-15, Volume: 18, Issue:10 | Design, synthesis and anticancer activities of stilbene-coumarin hybrid compounds: Identification of novel proapoptotic agents. |
| AID1371377 | Cytotoxicity against human SK-MEL-2 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID55048 | Minimum inhibitory concentration (MIC) that inhibits all visible growth of the Cryptococcus neoformans (fungus) at 64 ug/ml | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID719265 | Cytotoxicity against human MCF7 cells | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1). |
| AID1261103 | Down regulation of c-Myc gene expression in human HT-29 cells at 10 ug/mL after 48 hrs by RT-qPCR analysis relative to control | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Inhibitory effect of cytotoxic stilbenes related to resveratrol on the expression of the VEGF, hTERT and c-Myc genes. |
| AID264588 | Antiproliferative activity against human HL60 cell line | 2006 | Journal of medicinal chemistry, May-18, Volume: 49, Issue:10 | Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. |
| AID1557206 | Binding affinity to Streptococcus mutans GtfC | 2019 | MedChemComm, Jul-01, Volume: 10, Issue:7 | Targeting |
| AID343716 | Superoxide-scavenging activity assessed as inhibition of formation of WST1 formazan | 2008 | Journal of natural products, Jul, Volume: 71, Issue:7 | C-geranylated chalcones from the stems of Angelica keiskei with superoxide-scavenging activity. |
| AID359073 | Increase in DNA-binding activity of ERalpha in nuclear extracts of mouse MC3T3-E1 cells by electrophoretic mobility shift assays | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID455039 | Cytotoxicity against human OVCAR-3 cells after 48 hrs by sulforhodamine B assay | 2009 | Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18 | E-Combretastatin and E-resveratrol structural modifications: antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes. |
| AID713098 | Inhibition of mushroom tyrosinase assessed as L-tyrosine oxidation at 100 uM incubated 30 mins prior to substrate addition measured after 60 mins by UV-vis spectrophotometric analysis | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID1264945 | Induction of osteogenic differentiation in human MSC assessed as increase in ALP activity at 1 uM using p-NPP as substrate after 9 days by colorimetric method relative to control | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11 | Defining Key Structural Determinants for the Pro-osteogenic Activity of Flavonoids. |
| AID1424466 | Inhibition of recombinant human COX2 expressed in baculovirus assessed as reduction in PGE2 synthesis using [3H]arachidonic acid substrate by HPLC analysis | 2017 | European journal of medicinal chemistry, Dec-15, Volume: 142 | From bench (laboratory) to bed (hospital/home): How to explore effective natural and synthetic PAK1-blockers/longevity-promoters for cancer therapy. |
| AID416359 | Inhibition of Fe(2+)/ascorbate-induced lipid peroxidation in human erythrocyte ghosts assessed as increase in inhibition period | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6 | 4,4'-Dihydroxy-trans-stilbene, a resveratrol analogue, exhibited enhanced antioxidant activity and cytotoxicity. |
| AID359122 | Reversal of induction in BMP2 expression in mouse MC3T3-E1 cells transfected with dominant-negative mutant Src expression vector at 1 uM by Western blot | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID289279 | Inhibition of human recombinant COX2 by measuring PGE2 | 2007 | Bioorganic & medicinal chemistry, Sep-15, Volume: 15, Issue:18 | 'Bridged' stilbene derivatives as selective cyclooxygenase-1 inhibitors. |
| AID1256165 | Inhibition of Quorum sensing system in Chromobacterium violaceum CV026 at 1 to 4 mg/ml after 24 hrs by agar-well diffusion method | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | The quorum-sensing inhibiting effects of stilbenoids and their potential structure-activity relationship. |
| AID359310 | Effect on bone morphogenetic protein receptor 1B gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID491520 | Cellular uptake in human MCF7 cells assessed per millions cells at 50 uM after 24 hrs by LC/MS/MS analysis | 2010 | Journal of medicinal chemistry, Jul-08, Volume: 53, Issue:13 | Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. |
| AID1083157 | Antifungal activity against Lasiodiplodia theobromae CBS116460 assessed as growth inhibition measured after 1 to 10 days | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID1884064 | Antibacterial activity against Clostridium botulinum CECT551 incubated for 24 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID1357640 | Lipid lowering activity in zebrafish embryos by Nile red fat metabolism assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Lipid reducing activity and toxicity profiles of a library of polyphenol derivatives. |
| AID432240 | Inhibition of phagocytosis of FITC-conjugated Staphylococcus aureus 209P in human THP1 cells using trypan blue staining after 40 mins by flow cytometry | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID1309164 | Binding affinity to Mn2+ using MnCl2 at 20 uM after 5 mins by spectrophotometry | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Ionophoric polyphenols selectively bind Cu(2+), display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila. |
| AID598205 | Inhibition of amyloid beta (1 to 40) fibril formation at 10 uM by UV-visible spectrometry analysis | 2011 | Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10 | Protective effect of ε-viniferin on β-amyloid peptide aggregation investigated by electrospray ionization mass spectrometry. |
| AID730565 | Antinociceptive activity in Swiss mouse assessed as inhibition of capsaicin-induced spontaneous nociception at 600 ug/site, administered as intrathecally | 2013 | Journal of natural products, Jan-25, Volume: 76, Issue:1 | Evidence for the analgesic activity of resveratrol in acute models of nociception in mice. |
| AID416682 | Antimitotic activity in Lytechinus variegatus embryo assessed as inhibition of first cleavage at 43.8 uM relative to control | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Synthesis and biological evaluation of cytotoxic properties of stilbene-based resveratrol analogs. |
| AID434722 | Antioxidant activity assessed as DPPH radical scavenging activity at 200 uM | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Synthesis of novel trans-stilbene derivatives and evaluation of their potent antioxidant and neuroprotective effects. |
| AID1261705 | Inhibition of recombinant human Amyloid beta (1 to 42) self-induced aggregation at 5 uM after 48 hrs by thioflavin T-based fluorescence assay | 2015 | Journal of medicinal chemistry, Nov-12, Volume: 58, Issue:21 | Design, Synthesis, and Evaluation of Orally Available Clioquinol-Moracin M Hybrids as Multitarget-Directed Ligands for Cognitive Improvement in a Rat Model of Neurodegeneration in Alzheimer's Disease. |
| AID1326307 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC BAA-41 after 18 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24 | Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ. |
| AID1706446 | Anti-neuroinflammation in mouse BV2 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS addition measured after 24 hrs by Griess reagent based assay | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Design and synthesis of 3-(4-pyridyl)-5-(4-sulfamido-phenyl)-1,2,4-oxadiazole derivatives as novel GSK-3β inhibitors and evaluation of their potential as multifunctional anti-Alzheimer agents. |
| AID1190181 | Inhibition of amyloid beta (1 to 42) (unknown origin) self-induced aggregation at 20 uM after 46 to 48 hrs by thioflavin-T fluorescence method | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | Multifunctional coumarin derivatives: monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer's disease. |
| AID1309169 | Inhibition of Cu2+-amyloid beta (1 to 40) catalyzed generation of hydroxyl radical assessed as 7-hrdroxy-CCA formation at 2 equiv preincubated for 1 hr followed by CCA addition measured over 60 mins by fluorescence assay | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Ionophoric polyphenols selectively bind Cu(2+), display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila. |
| AID359324 | Effect on procollagen 4 alpha 6 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1406256 | Selectivity ratio of IC50 for human AChE to IC50 for human BChE | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities. |
| AID359178 | Inhibition of 2-[1,2-3H(N)]deoxy-D-glucose uptake in human U937 cells at >500 uM by scintillation spectrometry in presence of buffer containing NaCl and Na2HPO4 | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3 | Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells. |
| AID617271 | Metabolic stability in mouse serum up to 27 hrs by HPLC analysis | 2011 | ACS medicinal chemistry letters, Jan-25, Volume: 2, Issue:4 | The Use of 3,5,4'-Tri-O-acetylresveratrol as a Potential Pro-drug for Resveratrol Protects Mice from γ-Irradiation-Induced Death. |
| AID1826670 | Activation of Nrf2 in human Arec32 cells assessed as concentration required to double luciferase activity measured after 24 hrs | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades. |
| AID589144 | Mechanism based inhibition of human cytochrome P450 3A4 measured by testosterone 6-beta hydroxylation | 2005 | Current drug metabolism, Oct, Volume: 6, Issue:5 | Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. |
| AID726364 | Antioxidant activity assessed as DPPH radical scavenging activity at 100 uM after 30 mins by spectrophotometry | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Antioxidant activities of thiosemicarbazones from substituted benzaldehydes and N-(tetra-O-acetyl-β-D-galactopyranosyl)thiosemicarbazide. |
| AID730567 | Antinociceptive activity in Swiss mouse assessed as inhibition of capsaicin-induced spontaneous nociception at 150 ug/site, administered as intrathecally | 2013 | Journal of natural products, Jan-25, Volume: 76, Issue:1 | Evidence for the analgesic activity of resveratrol in acute models of nociception in mice. |
| AID1298436 | Potentiation of 5-Aza-C-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as Vif mutation at 50 uM incubated for 4 hrs preinfection followed by 5-Aza-C addition for 2 hrs preinfection and subsequen | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1534716 | Antioxidant activity assessed as ferric ion reduction by measuring trolox equivalents after 3 to 5 mins by FRAP assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease. |
| AID1371453 | Tmax in mouse at 10 mg/kg, iv by LC-MS/MS method | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1298403 | Increase in 5-aza-dCTP/dCTP ratio in human U373-MAGI cells at 200 uM preincubated for 2 hrs followed by 5-aza-C addition measured after 4 hrs by LC-MS/MS analysis relative to 5-aza-C | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1272531 | Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as induction of intracellular calcium level in presence of AITC | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | TRPA1 channels as targets for resveratrol and related stilbenoids. |
| AID764634 | Cytotoxicity against human estrogen receptor negative SKBR3 cells after 72 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17 | Synthesis and cytotoxic activity evaluation of 2,3-thiazolidin-4-one derivatives on human breast cancer cell lines. |
| AID1210971 | Plasma protein binding in mouse at 20 uM by equilibrium dialysis method | 2013 | Drug metabolism and disposition: the biological fate of chemicals, May, Volume: 41, Issue:5 | Pulmonary metabolism of resveratrol: in vitro and in vivo evidence. |
| AID1264946 | Induction of osteogenic differentiation in human MSC assessed as increase in ALP activity at 5 uM using p-NPP as substrate after 9 days by colorimetric method relative to control | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11 | Defining Key Structural Determinants for the Pro-osteogenic Activity of Flavonoids. |
| AID616422 | Displacement of [3H]-rosiglitazone from human recombinant C-terminal His-tagged cytosolic domain of mitoNEET (32-108) at 80 uM by scintillation proximity assay | 2011 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 21, Issue:18 | A novel binding assay identifies high affinity ligands to the rosiglitazone binding site of mitoNEET. |
| AID724579 | Binding affinity to planer lipid bilayer assessed as increase in cathodic current by cyclic voltammetric analysis | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Dose-dependent interaction of trans-resveratrol with biomembranes: effects on antioxidant property. |
| AID359541 | Effect on twist gene homolog 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1290891 | Inhibition of human erythrocyte acetylcholinesterase-mediated amyloid beta (1 to 40) aggregation at 100 uM after 24 hrs by thioflavin T fluorescence method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Pterostilbene-O-acetamidoalkylbenzylamines derivatives as novel dual inhibitors of cholinesterase with anti-β-amyloid aggregation and antioxidant properties for the treatment of Alzheimer's disease. |
| AID359552 | Effect on procollagen 19-alpha 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1168369 | Hepatoprotective activity against isoniazid-rifampicin induced liver injury in BALB/c mouse assessed as change in SIRT5 mRNA level at 100 mg/kg, po bid for 3 days starting 30 mins prior isoniazid-rifampicin administration measured 24 hrs post-last dose of | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. |
| AID642339 | Antioxidant activity assessed as DPPH free radical scavenging activity at 400 uM after 30 mins by spectrophotometry | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets. |
| AID1256180 | Decrease in lasI gene expression in Pseudomonas aeruginosa PAO1 at 400 uM by RT-PCR analysis relative to control | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | The quorum-sensing inhibiting effects of stilbenoids and their potential structure-activity relationship. |
| AID265507 | Antiproliferative activity against human HL60 cells | 2006 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 16, Issue:12 | Stilbene-based anticancer agents: resveratrol analogues active toward HL60 leukemic cells with a non-specific phase mechanism. |
| AID610304 | Stability in C57BL/6J mouse stomach at 84 mg/kg administered through intragastric route measured after 8 hrs by HPLC-MS-MS analysis | 2010 | Journal of medicinal chemistry, Oct-28, Volume: 53, Issue:20 | Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents. |
| AID1362629 | Inhibition of BACE 1 (unknown origin) at 50 uM using Rh-EVNLDAEFK-Quencher as substrate after 1 hr by FRET assay relative to control | |||
| AID1347857 | Inhibition of tyrosinase in human A375 cells assessed as effect on alpha-MSH-induced melanin formation at 25 uM after 24 hrs relative to control | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, synthesis and evaluation of novel dihydrostilbene derivatives as potential anti-melanogenic skin-protecting agents. |
| AID1081915 | Antifungal activity against Phomopsis obscurans assessed as growth inhibition at 30 uM after 144 hr by NCCLS M27-A broth microdilution method | 2011 | Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5 | Biological activity of peanut (Arachis hypogaea) phytoalexins and selected natural and synthetic Stilbenoids. |
| AID1608174 | Binding affinity to Keap1 in rat HBZY-1 cells assessed as induction of Keap1/Nrf2 signaling by measuring increase in GCLM mRNA expression at 6 uM by RT-PCR analysis | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Synthesis and assessment of phenylacrylamide derivatives as potential anti-oxidant and anti-inflammatory agents. |
| AID1326317 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis after 18 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24 | Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ. |
| AID638063 | Bactericidal activity against CagA-deficient Helicobacter pylori Ba142 isolated from chronic gastritis patient compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID208609 | The minimum inhibitory concentration (MIC) that inhibits all visible growth of the Streptococcus pneumoniae (bacteria) at 64 ug/ml | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID1609863 | Inhibition of recombinant human N-terminal His-tagged SGK1 using (GRPRTSSFAEGKK) peptide as substrate incubated for 30 mins in presence of [32P] gamma ATP by scintillation counter method | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Review about the multi-target profile of resveratrol and its implication in the SGK1 inhibition. |
| AID498483 | Inhibition of PLD | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2 | Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. |
| AID641150 | Inhibition of rat lens aldose reductase using DL-glyceraldehyde as substrate after 30 mins by fluorescence microplate reader analysis | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Antidiabetogenic oligostilbenoids and 3-ethyl-4-phenyl-3,4-dihydroisocoumarins from the bark of Shorea roxburghii. |
| AID1054209 | Cytotoxicity against human U373-MAGI cells by CellTitre-Glo assay | 2013 | Bioorganic & medicinal chemistry, Nov-15, Volume: 21, Issue:22 | 5,6-Dihydro-5-aza-2'-deoxycytidine potentiates the anti-HIV-1 activity of ribonucleotide reductase inhibitors. |
| AID273487 | Loss in viability of human HEK293T cells at 15 uM after 7 hrs relative to control | 2006 | Journal of medicinal chemistry, Nov-30, Volume: 49, Issue:24 | Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB. |
| AID637954 | Antibacterial activity against CagA-deficient Helicobacter pylori G104 isolated from chronic gastritis patient after 48 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1879014 | Upregulation of HGF protein expression in TGF-beta1 induced C57/B6J mouse primary hepatocytes in presence of miR-190a-5p mimic by Western blot analysis | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID762891 | Inhibition of H2O2-induced HUVEC senescence assessed as change in cellular morphology pretreated for 1 day followed by compound washout and H2O2-treatment measured after 10 days by hematoxylin staining-based assay | 2013 | Journal of natural products, Jul-26, Volume: 76, Issue:7 | trans-Resveratrol in Gnetum gnemon protects against oxidative-stress-induced endothelial senescence. |
| AID1362640 | Inhibition of Cu2+ induced amyloid beta (1 to 40) fibril aggregation assessed as fluorescence emission at 100 uM measured on day 7 by thioflavin-T based assay (Rvb = 181.04 +/- 1.74 No_unit) | |||
| AID359116 | Reversal of increase in BMP2 expression in mouse MC3T3-E1 cells expressing pBMP2/mSp1 mutant at 1 uM after 4 hrs by luciferase method | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID359104 | Antitumor activity against human MDA-MB-231 cells xenografted in SCID mouse orthotropic model assessed as inhibition of 17beta estradiol-induced tumor weight at 10 mg/kg for 2 days | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1371378 | Cytotoxicity against human U87 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID697844 | Inhibition of amyloid beta (1 to 40) aggregation assessed as induction of disaggregation treated 45 mins after formation of aggregates by thioflavin T fluorescence method | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22 | Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. |
| AID416964 | Antioxidant effect assessed as inhibition of AAPH-induced oxidative pBR322 plasmid DNA strand breakage at 10 uM by gel electrophoresis | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7 | Antioxidant-based lead discovery for cancer chemoprevention: the case of resveratrol. |
| AID359291 | Enhancement of FOXO3a activity in human MDA-MB-231 cells transfected with dominant negative Akt mutant | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1428598 | Inhibition of HFIP-pretreated amyloid beta (1 to 42) (unknown origin) self-induced aggregation at 20 uM incubated for 24 hrs under dark condition by thioflavin-T based fluorometric assay relative to control | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Synthesis and biological evaluation of deferiprone-resveratrol hybrids as antioxidants, Aβ |
| AID166394 | Inhibitory activity against nitric oxide production in lipopolysaccharide-activated mouse macrophage RAW264.7 cells | 2003 | Bioorganic & medicinal chemistry letters, Nov-03, Volume: 13, Issue:21 | Styrylheterocycles: a novel class of inhibitors on lipopolysaccharide-Induced nitric oxide production. |
| AID655172 | Cytotoxicity against human FHCC-98 cells after 24 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5 | A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. |
| AID642338 | Inhibition of TNFalpha-activated NF-kappaB expressed in HEK293 cells by luciferase reporter gene assay | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets. |
| AID1365634 | Antioxidant activity assessed as ABTS radical scavenging activity at 25 uM after 6 mins | 2017 | Bioorganic & medicinal chemistry, 11-01, Volume: 25, Issue:21 | Design, synthesis, and evaluation of salicyladimine derivatives as multitarget-directed ligands against Alzheimer's disease. |
| AID719272 | Inhibition of human aromatase activity at 50 uM after 30 mins by fluorescence analysis | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1). |
| AID724574 | Binding affinity to curcumin encapsulated liposomes assessed as curcumin release from unilamellar vesicles after 20 mins by NMR spectroscopic analysis | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Dose-dependent interaction of trans-resveratrol with biomembranes: effects on antioxidant property. |
| AID103219 | Cell growth inhibition of breast MCF-7 cells, expressed as 50% reduction in the net protein increase | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID360100 | Inhibition of antiapoptotic activity in rat primary osteoblast cells at 1 uM after 48 hrs in presence of noggin | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1452978 | Inhibition of recombinant CYP1B1 (unknown origin) expressed in supersomes coexpressing NADPH-CYP reductase using 7-ethoxyresorufin as substrate after 15 mins in presence of NADP+ by fluorescence spectrophotometric analysis | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Inhibitors of cytochrome P450 (CYP) 1B1. |
| AID1362758 | Effect on IL-1beta production in ear tissue of croton oil-induced Balb/c mouse ear edema model at 0.1 mg/ear administered topically immediately post croton oil treatment by ELISA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues. |
| AID1371452 | Cmax in mouse at 10 mg/kg, iv by LC-MS/MS method | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID403719 | Cytotoxicity against human MCF7 cells after 48 hrs by acid phosphatase method | 2005 | Journal of natural products, Oct, Volume: 68, Issue:10 | Cytotoxic furostanol saponins and a megastigmane glucoside from tribulus parvispinus. |
| AID1054211 | Antiviral activity against HIV1 infected in human U373-MAGI cells assessed as increase in mutant frequency incubated for 2 hrs prior to viral infection followed by compound washout after 24 hrs measured 72 hrs post-infection by flow cytometry | 2013 | Bioorganic & medicinal chemistry, Nov-15, Volume: 21, Issue:22 | 5,6-Dihydro-5-aza-2'-deoxycytidine potentiates the anti-HIV-1 activity of ribonucleotide reductase inhibitors. |
| AID1333797 | Antimigratory activity in human HeLa cells at 50 uM after 24 hrs by wound-scratch assay | 2017 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1 | Synthesis and bioactivity evaluation of 2,3-diaryl acrylonitrile derivatives as potential anticancer agents. |
| AID667231 | Cytotoxicity against human DLD1 cells after 96 hrs by SRB assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents. |
| AID1333787 | Selectivity index, ratio of IC50 for human L02 cells to IC50 for human Bel7402 cells | 2017 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1 | Synthesis and bioactivity evaluation of 2,3-diaryl acrylonitrile derivatives as potential anticancer agents. |
| AID1437794 | Antioxidant activity of the compound assessed as DPPH radical scavenging activity after 30 mins | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease. |
| AID1392706 | Inhibition of HFIP-pretreated amyloid beta (1 to 42) (unknown origin) self-induced aggregation at 10 uM after 48 hrs by thioflavin T-based fluorometric assay relative to control | |||
| AID759452 | Inhibition of Cu2+-induced amyloid beta (1 to 42) aggregation (unknown origin) at 50 uM after 24 hrs by thioflavin T fluorescence assay relative to untreated control | 2013 | Journal of medicinal chemistry, Jul-25, Volume: 56, Issue:14 | Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease. |
| AID1305342 | Inhibition of self-induced amyloid beta 42 (unknown origin) aggregation measured for 24 hrs by thioflavin T-based fluorescence spectroscopic analysis | 2016 | ACS medicinal chemistry letters, May-12, Volume: 7, Issue:5 | Structure-Activity Relationship Studies of Isomeric 2,4-Diaminoquinazolines on β-Amyloid Aggregation Kinetics. |
| AID1256182 | Decrease in rhII gene expression in Pseudomonas aeruginosa PAO1 at 400 uM by RT-PCR analysis | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | The quorum-sensing inhibiting effects of stilbenoids and their potential structure-activity relationship. |
| AID726365 | Antioxidant activity assessed as DPPH radical scavenging activity at 50 uM after 30 mins by spectrophotometry | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Antioxidant activities of thiosemicarbazones from substituted benzaldehydes and N-(tetra-O-acetyl-β-D-galactopyranosyl)thiosemicarbazide. |
| AID416357 | Inhibition of Fe(2+)/ascorbate-induced lipid peroxidation in human erythrocyte ghosts assessed as inhibition of malondialdehyde formation at 1 to 5 uM | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6 | 4,4'-Dihydroxy-trans-stilbene, a resveratrol analogue, exhibited enhanced antioxidant activity and cytotoxicity. |
| AID1352501 | Neuroprotective activity in PTZ challenged 5 days post fertilized zebra fish AB embryo assessed as recovery of AChE activity at 10 uM preincubated for 1 hr followed by PTZ addition and measured after 6 hrs by Ellman's method relative to control | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Alkylated resveratrol prodrugs and metabolites as potential therapeutics for neurodegenerative diseases. |
| AID1428601 | Binding affinity to Fe3+ assessed as inhibition of Fe3+-induced amyloid beta (1 to 42) aggregation by measuring Fe3+-amyloid beta (1 to 42) complex fluorescence at 50 uM incubated for 24 hrs under dark condition by thioflavin-T based fluorometric assay re | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Synthesis and biological evaluation of deferiprone-resveratrol hybrids as antioxidants, Aβ |
| AID418723 | Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B assay | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7 | Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. |
| AID1609864 | Induction of apoptosis in human HuH7 cells transfected with ShSGK1 assessed as late apoptosis at 100 uM incubated for 48 hrs by annexin V and 7-AAD staining based assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Review about the multi-target profile of resveratrol and its implication in the SGK1 inhibition. |
| AID1573647 | Activation of Nrf2 in rat HBZY-1 cells assessed as increase in NQO-1 level at 6 uM by Western blot analysis | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and biological evaluation of bifendate derivatives bearing acrylamide moiety as novel antioxidant agents. |
| AID1452016 | Inhibition of human TTR V30M mutant expressed in Escherichia coli BL-21 assessed as fibril formation at 7.2 uM incubated for 30 mins measured after 96 hrs by light scattering method relative to control | 2017 | Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18 | Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation. |
| AID1336830 | Antioxidant activity assessed as DPPH radical scavenging activity at 160 uM incubated for 30 mins under dark condition | 2017 | Bioorganic & medicinal chemistry, 02-01, Volume: 25, Issue:3 | Quinolines: Microwave-assisted synthesis and their antifungal, anticancer and radical scavenger properties. |
| AID637963 | Antibacterial activity against CagA-expressing Helicobacter pylori 328 isolated from chronic gastritis patient after 48 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID490192 | Antiproliferative activity against human SW480 cells assessed as cell viability using propidium iodide staining after 48 hrs | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Structural determinants of resveratrol for cell proliferation inhibition potency: experimental and docking studies of new analogs. |
| AID396456 | Antioxidant activity assessed as free radical scavenging activity at 5 uM | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Synthesis and in vitro biological activity of retinyl polyhydroxybenzoates, novel hybrid retinoid derivatives. |
| AID730939 | Antinociceptive activity in Swiss mouse assessed as inhibition of capsaicin-induced spontaneous nociception at 50 mg/kg, po | 2013 | Journal of natural products, Jan-25, Volume: 76, Issue:1 | Evidence for the analgesic activity of resveratrol in acute models of nociception in mice. |
| AID1311770 | Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as NO levels at 25 umol/L by ELISA (Rvb = 0.95 +/- 0.052 umol/mL) | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata. |
| AID455032 | Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay | 2009 | Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18 | E-Combretastatin and E-resveratrol structural modifications: antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes. |
| AID1494289 | Permeability of compound at 100 ug/ml after 10 hrs by PAMPA assay | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5 | Design, Synthesis, and Evaluation of Orally Bioavailable Quinoline-Indole Derivatives as Innovative Multitarget-Directed Ligands: Promotion of Cell Proliferation in the Adult Murine Hippocampus for the Treatment of Alzheimer's Disease. |
| AID713094 | Inhibition of mushroom tyrosinase-mediated L-DOPA oxidation assessed as decrease in dopachrome formation at 100 uM preincubated for 30 mins by HPLC analysis | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID402267 | Antioxidant activity against ABTS radical assessed as TEAC units | 2004 | Journal of natural products, May, Volume: 67, Issue:5 | Yucca schidigera bark: phenolic constituents and antioxidant activity. |
| AID549846 | Partial agonist activity at human ERalpha receptor expressed in human MCF7:D5L cells co-expressing ERE assessed as increase of estradiol-induced luciferase gene expression at 1 uM after 18 hrs relative to estradiol | 2011 | Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1 | New hydroxystilbenoid derivatives endowed with neuroprotective activity and devoid of interference with estrogen and aryl hydrocarbon receptor-mediated transcription. |
| AID637956 | Antibacterial activity against CagA-deficient Helicobacter pylori NS23 isolated from chronic gastritis patient after 48 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID258723 | Noradrenaline induced vasorelaxant activity in intact rat aortic rings | 2006 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 16, Issue:2 | Design, synthesis, and vasorelaxant and platelet antiaggregatory activities of coumarin-resveratrol hybrids. |
| AID735922 | Activation of SIRT1 R446A mutant (unknown origin) | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate. |
| AID1298381 | Reduction in 5-aza-dCTP level in human U373-MAGI cells at 50 uM preincubated for 2 hrs followed by 5-aza-C addition measured after 4 hrs by LC-MS/MS analysis | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1884061 | Antibacterial activity against Staphylococcus aureus LMG 10147 incubated for 20 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID1878985 | Inhibition of TGF-beta1 induced apoptosis in C57/B6J mouse primary hepatocytes assessed as dead cells at 10 uM by Annexin-V-FITC-H and PI staining based flow cytometry analysis (Rvb = 3.09 %) | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID638052 | Antibacterial activity against CagA-expressing Helicobacter pylori 18K7 isolated from gastric carcinoma patient after 48 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1879026 | Antifibrotic activity in CCL-4 induced liver fibrosis C57/B6J mouse model transfected with miR-190a-5p agomir assessed as reduction in serum AST level at 100 mg/kg/day, ip measured after 72 hrs post last dose by ELISA | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID331042 | Activation of SIRT3 by mass spectrometry assay | 2007 | Nature, Nov-29, Volume: 450, Issue:7170 | Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. |
| AID359314 | Effect on procollagen 9 alpha 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID416362 | Inhibition of Fe(2+)/ascorbate-induced lipid peroxidation in human erythrocyte ghosts assessed as inhibition of malondialdehyde formation per mg of protein at 3 uM after 30 mins | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6 | 4,4'-Dihydroxy-trans-stilbene, a resveratrol analogue, exhibited enhanced antioxidant activity and cytotoxicity. |
| AID432150 | Inhibition of FSL1-induced NF-kappaB activation in HEK293 cells expressing TLR2 pretreated for 1 hr before 6 hrs-FSL1 stimulation by luciferase reporter gene assay | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID404511 | Aqueous solubility assessed per 100 g at pH 7 | 2008 | Bioorganic & medicinal chemistry, Jun-15, Volume: 16, Issue:12 | Design, synthesis and spectroscopic studies of resveratrol aliphatic acid ligands of human serum albumin. |
| AID1261089 | Down regulation of VEGF gene expression in human HT-29 cells at 10 ug/mL after 48 hrs by RT-qPCR analysis relative to control | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Inhibitory effect of cytotoxic stilbenes related to resveratrol on the expression of the VEGF, hTERT and c-Myc genes. |
| AID1081917 | Antifungal activity against Diaporthe ampelina assessed as growth inhibition after 120 hr by NCCLS M27-A broth microdilution method | 2011 | Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5 | Biological activity of peanut (Arachis hypogaea) phytoalexins and selected natural and synthetic Stilbenoids. |
| AID589132 | Mechanism based inhibition of human cytochrome P450 3A4 measured by testosterone 6-beta hydroxylation | 2005 | Current drug metabolism, Oct, Volume: 6, Issue:5 | Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. |
| AID1246397 | Agonist activity at ERbeta (248 to 510 amino acid residues) (unknown origin) assessed as induction of interaction with SRC1 after 24 hrs by yeast two-hybrid assay relative to isopaucifloral F | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Synthesis, estrogenic activity, and anti-osteoporosis effects in ovariectomized rats of resveratrol oligomer derivatives. |
| AID1878980 | Antifibrotic activity in CCL-4 induced liver fibrosis C57/B6J mouse model transfected with miR-190a-5p agomir assessed as reduction in disorganized and interlaced fibers at 100 mg/kg/day, ip measured after 72 hrs post last dose by HE/Sirus red/TUNEL stain | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID491618 | Inhibition of sheep seminal vesicles COX1 assessed as PGE2 production at 34 uM after 10 mins by ELISA relative to control | 2010 | Journal of medicinal chemistry, Jul-08, Volume: 53, Issue:13 | Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. |
| AID400271 | Blockade of delayed rectifier potassium channel in mouse rat hybrid F11 cells at 90 uM by whole-cell patch clamp technique | 2004 | Journal of natural products, Mar, Volume: 67, Issue:3 | Resveratrol derivatives and their role as potassium channels modulators. |
| AID336035 | Inhibition of rat brain PKC | 1993 | Journal of natural products, Oct, Volume: 56, Issue:10 | Kinase inhibitors from Polygonum cuspidatum. |
| AID640885 | Antioxidant activity assessed as inhibition of lipid peroxidation | 2012 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 22, Issue:2 | Antioxidative oligostilbenes from Caragana sinica. |
| AID377458 | Estrogenic activity in human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 100 pM estradiol by alamar blue assay | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3 | Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines. |
| AID1311773 | Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as iNOS levels at 25 umol/L by ELISA (Rvb = 31.63 +/- 3.26 U/mL) | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata. |
| AID1676793 | Induction of membrane perturbation in DC18:1PC LUV bilayer assessed as fluorescence quench rate by measuring gramicidin mixture monomer to dimer equilibrium at 30 uM by fluorescence quenching assay | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20 | Assessing the Perturbing Effects of Drugs on Lipid Bilayers Using Gramicidin Channel-Based |
| AID650852 | Cytotoxicity against human MCF7 cells by SRB assay | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7 | Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol. |
| AID1246396 | Antagonist activity at ERalpha (301 to 553 amino acid residues) (unknown origin) assessed as inhibition of E2 induced interaction with SRC1 after 24 hrs by yeast-two-hybrid assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Synthesis, estrogenic activity, and anti-osteoporosis effects in ovariectomized rats of resveratrol oligomer derivatives. |
| AID610303 | Increase in Clostridia count in C57BL/6J mouse distal colon mucosa with DSS-induced colon inflammation at 2.1 mg/kg/day, po for 21 days followed by compound dosing for 8 days co-administered with DSS followed by 2.1 mg/kg/day, po dosing for 6 days in abse | 2010 | Journal of medicinal chemistry, Oct-28, Volume: 53, Issue:20 | Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents. |
| AID1311761 | Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as TNFalpha levels at 25 umol/L by ELISA (Rvb = 183.21 +/- 5.36 pg/mL) | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata. |
| AID471945 | Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay | 2009 | Journal of natural products, Sep, Volume: 72, Issue:9 | Antineoplastic agents. 579. Synthesis and cancer cell growth evaluation of E-stilstatin 3: a resveratrol structural modification. |
| AID655205 | Inhibition of human FHCC-98 cell adhesion to matrigel-coated plates at 100 uM after 30 to 60 mins by crystal violet staining-based spectrophotometry | 2012 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5 | A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. |
| AID1872878 | Inhibition of Bacillus stearothermophilus alpha-glucosidase type IV using p-nitrophenyl-alpha-D-glucopyranoside as substrate preincubated for 15 mins followed by substrate addition and measured after 35 mins by microtiter plate reader analysis | 2022 | European journal of medicinal chemistry, May-05, Volume: 235 | Recent results from non-basic glycosidase inhibitors: How structural diversity can inform general strategies for improving inhibition potency. |
| AID1570227 | Cytoprotective activity against hypoxia-induced toxicity rat H9c2 cells assessed as increase in cell viability at 80 nM to 7 uM incubated for 18 hrs in hypoxia measured after 48 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors. |
| AID359288 | Reversal of induction of FOXO3a activity in human MDA-MB-231 cells transfected with constitutively activated Akt mutant | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1499671 | Inhibition of SQS in rat microsomes using [3H]-FPP as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins by scintillation counting | 2017 | European journal of medicinal chemistry, Sep-29, Volume: 138 | Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity. |
| AID359108 | Increase in BMP2 levels in rat primary osteoblast cells at 1 uM after 48 hrs by ELISA | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1190179 | Inhibition of human recombinant MAO-B using p-tyramine as substrate assessed as H2O2 production after 15 mins by fluorescence assay | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | Multifunctional coumarin derivatives: monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer's disease. |
| AID1632228 | Cytotoxicity against human DU145 cells assessed as inhibition of cell viability at 2 to 500 uM after 24 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18 | Synthesis and anticancer activity of a hydroxytolan series. |
| AID1054848 | Inhibition of human recombinant TTR Y78F mutant-mediated fibrillogenesis after 30 mins by turbidimetric assay | 2013 | Journal of medicinal chemistry, Nov-27, Volume: 56, Issue:22 | Modulation of the fibrillogenesis inhibition properties of two transthyretin ligands by halogenation. |
| AID1450142 | Down regulation of hTERT expression in human HT-29 cells assessed as hTERT expression level at 1 uM after 48 hrs by RT-qPCR analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11 | One drug for two targets: Biological evaluation of antiretroviral agents endowed with antiproliferative activity. |
| AID315992 | Inhibition of COX2 in human whole blood assessed as effect on LPS-stimulated PGE2 production | 2008 | Bioorganic & medicinal chemistry, Mar-01, Volume: 16, Issue:5 | Selective COX-2 inhibitors. Part 2: synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides. |
| AID491524 | Antioxidant activity assessed as DPPH scavenging activity after 30 mins | 2010 | Journal of medicinal chemistry, Jul-08, Volume: 53, Issue:13 | Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. |
| AID402268 | Antioxidant activity against beta-carotene and linoleic acid assessed as inhibition of bleaching of beta-carotene at 60 mins by autooxidation assay | 2004 | Journal of natural products, May, Volume: 67, Issue:5 | Yucca schidigera bark: phenolic constituents and antioxidant activity. |
| AID359284 | Inhibition of IGF-induced FOXO3a phosphorylation at Thr32 residue in human MDA-MB-231 cells by Western blot | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID359503 | Effect on fibronectin 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1190178 | Inhibition of human recombinant MAO-A using p-tyramine as substrate assessed as H2O2 production at 100 uM after 15 mins by fluorescence assay | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | Multifunctional coumarin derivatives: monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer's disease. |
| AID770331 | Plasma concentration in human | 2013 | Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19 | Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2. |
| AID639317 | Antibacterial activity against CagA-deficient Helicobacter pylori G204 isolated from chronic gastritis patient after 24 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID432239 | Inhibition of phagocytosis of FITC-conjugated Staphylococcus aureus 209P in human THP1 cells using trypan blue staining after 20 mins by flow cytometry | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID1225525 | Reduction in iNOS expression in prostate tissue in BPH-induced Sprague-Dawley rat model at 1 mg/kg, ip daily for 4 weeks by Western blot analysis | 2015 | Journal of natural products, Apr-24, Volume: 78, Issue:4 | Effects of resveratrol on benign prostatic hyperplasia by the regulation of inflammatory and apoptotic proteins. |
| AID378352 | Inhibition of bovine NADH-ubiquinone oxidoreductase | 1999 | Journal of natural products, Feb, Volume: 62, Issue:2 | New bioactive flavonoids and stilbenes in cubé resin insecticide. |
| AID259477 | Cytotoxicity against breast cancer MDA-MB-231 cell line by MTT assay at 100 uM | 2006 | Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2 | Rapid synthesis of triazole-modified resveratrol analogues via click chemistry. |
| AID406771 | DPPH radical scavenging activity at 200 uM | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | Efficient synthesis and neuroprotective effect of substituted 1,3-diphenyl-2-propen-1-ones. |
| AID608253 | Antibacterial activity against 1 x 10'4 cfu/mL Escherichia coli ATCC 11303 after 24 hrs by NCCLS M7-A6 microtiter broth dilution method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis and antimicrobial evaluation of new benzofuran derivatives. |
| AID1062133 | Antibiofilm activity against Escherichia coli O157:H7 assessed as effect on rrsG expression at 20 ug/ml after 5 hrs by qRT-PCR analysis | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1 | Resveratrol oligomers inhibit biofilm formation of Escherichia coli O157:H7 and Pseudomonas aeruginosa. |
| AID1662941 | Antioxidant activity assessed as ABTS radical scavenging activity by spectrophotometric analysis | 2020 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 30, Issue:13 | Synthesis, biological evaluation of benzothiazole derivatives bearing a 1,3,4-oxadiazole moiety as potential anti-oxidant and anti-inflammatory agents. |
| AID1392708 | Antioxidant activity assessed as trolox equivalents of AAPH radical scavenging activity at 10 uM preincubated for 15 mins followed by AAPH addition measured every minute for 120 mins by ORAC-FL assay | |||
| AID1054180 | Antiviral activity against HIV1 infected in human U373-MAGI cells assessed as C to T mutation at 50 uM (Rvb = 13%) | 2013 | Bioorganic & medicinal chemistry, Nov-15, Volume: 21, Issue:22 | 5,6-Dihydro-5-aza-2'-deoxycytidine potentiates the anti-HIV-1 activity of ribonucleotide reductase inhibitors. |
| AID1306441 | Inhibition of recombinant human CYP1A1 expressed in Escherichia coli DH5aplha cells assessed as O-deethylation of ethoxyresorufin in presence of NADPH measured after 2 mins by spectrofluorometric method | 2016 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 26, Issue:14 | Aryl morpholino triazenes inhibit cytochrome P450 1A1 and 1B1. |
| AID1878992 | Inhibition of TGF-beta1 induced apoptosis in C57/B6J mouse primary hepatocytes assessed as late apoptotic cells at 50 uM by Annexin-V-FITC-H and PI staining based flow cytometry analysis (Rvb = 12.12 %) | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID66074 | The minimum inhibitory concentration (MIC) that inhibits all visible growth of the Enterobacter cloacae (bacteria) at 64 ug/ml | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID1632203 | Cytotoxicity against human T24 cells after 72 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18 | Synthesis and anticancer activity of a hydroxytolan series. |
| AID359188 | Inhibition of [14C]dehydroascorbic acid uptake in human HL60 cells by scintillation spectrometry in presence of sodium-free buffer | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3 | Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells. |
| AID1485916 | Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using p-tyramine as substrate pretreated for 15 mins followed by substrate addition after 20 mins by Amplex red reagent based fluorimetric method | 2017 | Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14 | Synthesis and pharmacological evaluation of novel chromone derivatives as balanced multifunctional agents against Alzheimer's disease. |
| AID359054 | Induction of FOXO3a activity in human MDA-MB-231 cells | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID650849 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at 40 uM preincubated for 30 mins measured 24 hrs post LPS challenge by Griess method | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7 | Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol. |
| AID331064 | Reduction of insulin level in chow-fed C57BL/6 mouse | 2007 | Nature, Nov-29, Volume: 450, Issue:7170 | Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. |
| AID359548 | Effect on glyceraldehyde-3-phosphate dehydrogenase gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID501914 | Inhibition of human carbonic anhydrase 14 after 15 mins by stopped flow CO2 hydration method | 2010 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17 | Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. |
| AID749796 | Inhibition of VEGF protein production in human HT-29 cells at 20 ug/mL after 72 hrs by ELISA relative to control | 2013 | Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11 | Inhibition of VEGF expression in cancer cells and endothelial cell differentiation by synthetic stilbene derivatives. |
| AID315993 | Selectivity for human COX2 over human COX1 by human whole blood assay | 2008 | Bioorganic & medicinal chemistry, Mar-01, Volume: 16, Issue:5 | Selective COX-2 inhibitors. Part 2: synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides. |
| AID416965 | Inhibition of hydrogen peroxide-induced cell death of BALB/c mouse thymocytes preincubated for 30 mins before hydrogen peroxide challenge measured after 24 hrs by MTT assay | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7 | Antioxidant-based lead discovery for cancer chemoprevention: the case of resveratrol. |
| AID1407186 | Antioxidant activity assessed as trolox equivalent of AAPH-induced radical scavenging activity preincubated for 15 mins followed by AAPH addition measured every minute for 120 mins by ORAC-FL based fluorescein assay | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties. |
| AID1225531 | Increase in Bax expression in prostate tissue in BPH-induced Sprague-Dawley rat model at 1 mg/kg, ip daily for 4 weeks by Western blot analysis | 2015 | Journal of natural products, Apr-24, Volume: 78, Issue:4 | Effects of resveratrol on benign prostatic hyperplasia by the regulation of inflammatory and apoptotic proteins. |
| AID359290 | Enhancement of FOXO3a nuclear accumulation in human MDA-MB-231 cells transfected with dominant negative Akt mutant | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1309186 | Toxicity in Tetrahymena thermophila assessed as reduction in cell viability after 48 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Ionophoric polyphenols selectively bind Cu(2+), display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila. |
| AID1057862 | Inhibition of RML prion protein infected in mouse dividing ScN2a-cl3 cells expressing full length mouse PrP assessed as reduction of PrPsc level after 5 days by ELISA | 2013 | Bioorganic & medicinal chemistry, Dec-15, Volume: 21, Issue:24 | Antiprion compounds that reduce PrP(Sc) levels in dividing and stationary-phase cells. |
| AID730559 | Antinociceptive activity in Swiss mouse assessed as inhibition of capsaicin-induced increase of c-Fos expression in L3-L6 spinal segments at 100 mg/kg, po by immunohistochemistry analysis | 2013 | Journal of natural products, Jan-25, Volume: 76, Issue:1 | Evidence for the analgesic activity of resveratrol in acute models of nociception in mice. |
| AID1371387 | Cytotoxicity against human PANC1 cells assessed as cell viability at 16 uM after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1168367 | Hepatoprotective activity against isoniazid-rifampicin induced liver injury in BALB/c mouse assessed as change in SIRT3 mRNA level at 100 mg/kg, po bid for 3 days starting 30 mins prior isoniazid-rifampicin administration measured 24 hrs post-last dose of | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. |
| AID1878989 | Inhibition of TGF-beta1 induced apoptosis in C57/B6J mouse primary hepatocytes assessed as dead cells at 25 uM by Annexin-V-FITC-H and PI staining based flow cytometry analysis (Rvb = 3.09 %) | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID1290890 | Inhibition of self-induced amyloid beta (1 to 42) aggregation (unknown origin) at 25 uM after 24 hrs by thioflavin T fluorescence method | 2016 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8 | Pterostilbene-O-acetamidoalkylbenzylamines derivatives as novel dual inhibitors of cholinesterase with anti-β-amyloid aggregation and antioxidant properties for the treatment of Alzheimer's disease. |
| AID1371384 | Cytotoxicity against human A549 cells assessed as cell viability at 16 uM after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1298434 | Potentiation of 5-Aza-C-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as Gag mutation at 50 uM incubated for 4 hrs preinfection followed by 5-Aza-C addition for 2 hrs preinfection and subsequen | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID359278 | Reversal of increase in DNA-binding activity of ERalpha in nuclear extracts of mouse MC3T3-E1 cells transfected with dominant-negative mutant Src expression vector by electrophoretic mobility shift assays | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1811678 | Binding affinity to Bacillus subtilis FtsZ assessed as decrease in fluorescence anisotropy values at 20 to 200 uM by fluorescence anisotropy analysis | 2021 | Journal of medicinal chemistry, 05-13, Volume: 64, Issue:9 | Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial Discovery. |
| AID1371035 | Antimalarial activity against Plasmodium falciparum | 2017 | Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12 | Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives. |
| AID289280 | Selectivity for ovine COX1 over human recombinant COX2 | 2007 | Bioorganic & medicinal chemistry, Sep-15, Volume: 15, Issue:18 | 'Bridged' stilbene derivatives as selective cyclooxygenase-1 inhibitors. |
| AID1570226 | Cytoprotective activity against hypoxia-induced toxicity rat H9c2 cells assessed as increase in cell viability at 80 nM to 7 uM preincubated for 18 hrs followed by incubated in hypoxia for 48 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors. |
| AID730555 | Antinociceptive activity in Swiss mouse assessed as inhibition of capsaicin-induced increase of COX2 expression in L3-L6 spinal segments and cerebral cortex at 100 mg/kg, po by immunohistochemistry analysis | 2013 | Journal of natural products, Jan-25, Volume: 76, Issue:1 | Evidence for the analgesic activity of resveratrol in acute models of nociception in mice. |
| AID1198740 | Inhibition of Saccharomyces cerevisiae alpha-glucosidase using 4-NPGP substrate assessed as reduction in 4-nitrophenol release pre-incubated for 10 mins before substrate addition by microplate reader based assay | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93 | Antioxidant activity and inhibition of α-glucosidase by hydroxyl-functionalized 2-arylbenzo[b]furans. |
| AID1700048 | Selectivity index, ratio of IC50 for human serum BuChE to IC50 for human erythrocytes AChE | 2020 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 30, Issue:24 | Novel deoxyvasicinone and tetrahydro-beta-carboline hybrids as inhibitors of acetylcholinesterase and amyloid beta aggregation. |
| AID1371382 | Cytotoxicity against human HT-29 cells assessed as cell viability at 16 uM after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID430022 | Antiproliferative activity against human HT144 cells after 5 days by acid phosphatase assay | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13 | Synthesis, structural characterisation and biological evaluation of fluorinated analogues of resveratrol. |
| AID1872751 | Neuroprotective activity against H2o2-induced rat PC-12 cells assessed as cell viability preincubated for 2 hrs followed by H2O2 treatment measured after 24 hrs by MTT assay | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy. |
| AID359531 | Effect on SRY-box gene 9 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1371374 | Cytotoxicity against human BxPC3 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1372021 | Antioxidant activity assessed as Trolox equivalents of photolysis-induced alkoxyl scavenging activity using DMPO spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID1573649 | Activation of Nrf2 in rat HBZY-1 cells assessed as increase in GCLM level at 6 uM by Western blot analysis | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and biological evaluation of bifendate derivatives bearing acrylamide moiety as novel antioxidant agents. |
| AID1428602 | Binding affinity to Cu2+ assessed as inhibition of Cu2+-induced amyloid beta (1 to 42) aggregation by measuring Cu2+-amyloid beta (1 to 42) complex fluorescence at 75 uM incubated for 24 hrs under dark condition by thioflavin-T based fluorometric assay re | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Synthesis and biological evaluation of deferiprone-resveratrol hybrids as antioxidants, Aβ |
| AID1062127 | Antibiofilm activity against Pseudomonas aeruginosa PA14 after 24 hrs by GFP-based confocal laser microscopy | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1 | Resveratrol oligomers inhibit biofilm formation of Escherichia coli O157:H7 and Pseudomonas aeruginosa. |
| AID1352499 | Inhibition of LPS-induced IL-6 production in rat RAW264.7 cells at 10 uM after 24 hrs by ELISA | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Alkylated resveratrol prodrugs and metabolites as potential therapeutics for neurodegenerative diseases. |
| AID1385445 | Inhibition of NFkappaB in mouse RAW 264.7 cells assessed as reduction in LPS induced NO production after 24 hrs in presence of OBHS by Griess assay | 2018 | Journal of medicinal chemistry, 09-27, Volume: 61, Issue:18 | Novel Hybrid Conjugates with Dual Suppression of Estrogenic and Inflammatory Activities Display Significantly Improved Potency against Breast Cancer. |
| AID1882447 | Inhibition of HDAC1 derived from human HeLa cell nuclear extract at 100 uM incubated for 2 hrs relative to control | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4 | Chasing a Breath of Fresh Air in Cystic Fibrosis (CF): Therapeutic Potential of Selective HDAC6 Inhibitors to Tackle Multiple Pathways in CF Pathophysiology. |
| AID738209 | Cytotoxicity against human SK-MEL cells assessed as growth inhibition measured after 48 hrs by XTT assay | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID359518 | Effect on MAD homolog 5 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1333796 | Selectivity index, ratio of IC50 for human L02 cells to IC50 for human HeLa cells | 2017 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1 | Synthesis and bioactivity evaluation of 2,3-diaryl acrylonitrile derivatives as potential anticancer agents. |
| AID359060 | Antiproliferative activity against human T47D cells at 1 uM by flow cytometry | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID418725 | Cytotoxicity against human Lu cells after 72 hrs by sulforhodamine B assay | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7 | Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. |
| AID401039 | Antioxidant activity assessed as DPPH radical scavenging activity | 1998 | Journal of natural products, May, Volume: 61, Issue:5 | Isolation, identification, and antioxidant activity of three stilbene glucosides newly extracted from vitis vinifera cell cultures |
| AID1203644 | Cell cycle arrest in human Bel7402 cells assessed as cells accumulation at G2/M phase at 50 uM after 48 hrs by flow cytometry (Rvb = 16.61%) | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Design, synthesis, and biological evaluation of benzoselenazole-stilbene hybrids as multi-target-directed anti-cancer agents. |
| AID1168360 | Hepatoprotective activity against isoniazid-rifampicin induced liver injury in BALB/c mouse assessed as reduction in fatty accumulation at 100 mg/kg, po bid for 3 days starting 30 mins prior isoniazid-rifampicin administration measured 24 hrs post-last do | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. |
| AID1430683 | Cmax in Wistar rat at 20 mg/kg, po by HPLC-MS analysis | 2017 | ACS medicinal chemistry letters, May-11, Volume: 8, Issue:5 | Toward Resolving the Resveratrol Conundrum: Synthesis and |
| AID1498853 | Inhibition of self-induced human amyloid beta (1 to 42) aggregation at 25 uM after 24 hrs by thioflavin-T based fluorescence assay relative to control | 2018 | Bioorganic & medicinal chemistry, 07-30, Volume: 26, Issue:13 | Design, synthesis and evaluation of novel bivalent β-carboline derivatives as multifunctional agents for the treatment of Alzheimer's disease. |
| AID1519074 | Stability of compound in IMDM cell medium incubated for 24 hrs by HPLC analysis | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | From bench to counter: Discovery and validation of a peony extract as tyrosinase inhibiting cosmeceutical. |
| AID432139 | Inhibition of phagocytosis of FITC-conjugated Escherichia coli K12 in human THP1 cells using trypan blue staining after 80 mins by flow cytometry | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID614083 | Antibacterial activity against Micrococcus luteus ATCC 381 at 10 mg/ml after 24 to 72 hrs by agar diffusion method | 2011 | Bioorganic & medicinal chemistry, Sep-01, Volume: 19, Issue:17 | Synthesis and antimicrobial activity of (E) stilbene derivatives. |
| AID1298276 | Antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as reduction in viral infectivity preincubated for 2 to 8 hrs followed by viral infection measured at 72 hrs post infection by flow cytometric analysis | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID713108 | Drug metabolism assessed as oxidation of the compound at 100 uM after 30 mins by HPLC analysis in the presence of tyrosinase | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID1480846 | Inhibition of human erythrocyte AChE at 5 uM using acetylthiocholine chloride as substrate pretreated for 15 mins followed by substrate addition measured for 2 mins by DTNB reagent based spectrophotometric method relative to control | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment. |
| AID481133 | Binding affinity to Vaccinia virus recombinant N1L expressed in Escherichia coli BL21 (DE3) assessed as effect on enthalpy of protein unfolding at 214 uM by differential scanning calorimetry | 2010 | Journal of medicinal chemistry, May-27, Volume: 53, Issue:10 | Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention. |
| AID434721 | Antioxidant activity assessed as DPPH radical scavenging activity at 100 uM | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Synthesis of novel trans-stilbene derivatives and evaluation of their potent antioxidant and neuroprotective effects. |
| AID610405 | Effect on body weight in C57BL/6J mouse model of DSS-induced colon inflammation at 2.1 mg/kg/day, po for 21 days followed by compound dosing for 8 days co-administered with DSS followed by 2.1 mg/kg/day, po dosing for 6 days in absence of DSS measured on | 2010 | Journal of medicinal chemistry, Oct-28, Volume: 53, Issue:20 | Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents. |
| AID1311765 | Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as IL1beta levels at 50 umol/L by ELISA (Rvb = 8.70 +/- 0.365 pg/mL) | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata. |
| AID1237136 | Anti-inflammatory activity in C57BL/6 mouse model of LPS-induced acute lung injury assessed as reduction in lung CD68-stained macrophages level at 20 mg/kg for 1 week dosed before LPS instillation for 6 hrs by immunohistochemistry method | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15 | Design, synthesis and biological evaluation of paralleled Aza resveratrol-chalcone compounds as potential anti-inflammatory agents for the treatment of acute lung injury. |
| AID1418624 | Inhibition of HFIP-pretreated amyloid beta (1 to 42) (unknown origin) self-induced aggregation at 20 uM after 24 hrs by thioflavin-T fluorescence assay relative to control | 2018 | Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22 | Resveratrol-maltol hybrids as multi-target-directed agents for Alzheimer's disease. |
| AID1879016 | Antifibrotic activity in CCL-4 induced liver fibrosis C57/B6J mouse model assessed as reduction in disorganized and interlaced fibers at 100 mg/kg/day, ip measured after 72 hrs post last dose by HE/Sirus red/TUNEL staining based analysis | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID1362747 | Antiinflammatory activity in mouse J774A.1 cells assessed as inhibition of LPS-induced IL-1beta production by measuring IL-1beta levels incubated with LPS for 1 hr followed by compound addition measured after 24 hrs by ELISA (Rvb = 382.3 +/- 50 pg/ml) | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues. |
| AID1676775 | Induction of membrane perturbation in DC22:1PC LUV bilayer assessed as change in deltaG for pure gramicidin monomer to to dimer by fluorescence quenching assay (Rvb = 0 kcal/mol) | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20 | Assessing the Perturbing Effects of Drugs on Lipid Bilayers Using Gramicidin Channel-Based |
| AID359550 | Effect on ribosomal protein L13a gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID770330 | Binding affinity to human quinone reductase 2 by ITC analysis | 2013 | Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19 | Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2. |
| AID1896329 | Activation of human N-terminal hexa-histidine tagged SIRT1 expressed in Escherichia coli BL21 (DE3) using peptide substrate by fluorescence polarization assay | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | The Pursuit of Enzyme Activation: A Snapshot of the Gold Rush. |
| AID1430667 | Thermodynamic solubility in pH 7.4 PBS at 10 mg/ml after 1 hr by LC-Ms/MS based shake flask method | 2017 | ACS medicinal chemistry letters, May-11, Volume: 8, Issue:5 | Toward Resolving the Resveratrol Conundrum: Synthesis and |
| AID637960 | Antibacterial activity against CagA-expressing Helicobacter pylori CCUG17874 isolated from chronic gastritis patient after 48 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID359172 | Inhibition of 2-[1,2-3H(N)]deoxy-D-glucose uptake in human U937 cells at 73 uM by scintillation spectrometry in presence of buffer containing NaCl and Na2HPO4 | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3 | Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells. |
| AID1178160 | Antioxidant activity of the compound assessed as reduction in absorbance of DPPH after 60 mins incubation by DPPH radical scavenging /microplate assay | 2014 | Bioorganic & medicinal chemistry, May-01, Volume: 22, Issue:9 | Synthesis, antioxidant and photoprotection activities of hybrid derivatives useful to prevent skin cancer. |
| AID617270 | Radioprotective activity against 9.75 Gy gamma radiation-induced death in C57BL/6NHsd mouse assessed as increase in survival rate at 25 mg/kg, ip administered 10 mins after irradiation daily for 4 days | 2011 | ACS medicinal chemistry letters, Jan-25, Volume: 2, Issue:4 | The Use of 3,5,4'-Tri-O-acetylresveratrol as a Potential Pro-drug for Resveratrol Protects Mice from γ-Irradiation-Induced Death. |
| AID762887 | Effect on eNOS expression in H2O2-induced HUVEC pretreated for 1 day followed by compound washout and H2O2-treatment measured after 10 days by immunoblotting analysis | 2013 | Journal of natural products, Jul-26, Volume: 76, Issue:7 | trans-Resveratrol in Gnetum gnemon protects against oxidative-stress-induced endothelial senescence. |
| AID70140 | The minimum inhibitory concentration (MIC) that inhibits all visible growth of the Escherichia coli (bacteria) at 64 ug/ml | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID479117 | Cell cycle arrest in human H460 cells assessed as accumulation at G2/M phase after 24 hrs by propidium iodide staining-based flow cytometry | 2010 | Bioorganic & medicinal chemistry, May-15, Volume: 18, Issue:10 | Design, synthesis and anticancer activities of stilbene-coumarin hybrid compounds: Identification of novel proapoptotic agents. |
| AID1362650 | Disaggregation of Cu2+ induced amyloid beta (1 to 40) preformed fibrils assessed as fluorescence emission at 100 uM after 4 days by thioflavin-T based assay (Rvb = 178.07 +/- 17.24 No_unit) | |||
| AID1826669 | Selectivity index, ratio of IC50 for recombinant human MAO-A to IC50 for recombinant human MAO-B using tyramine as substrate | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades. |
| AID1311915 | Inhibition of equine BCHE preincubated for 6 mins followed by addition of S-butyrylcholine iodide as substrate by Ellman's method | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18 | Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin. |
| AID655279 | Inhibition of human FHCC-98 cell invasion/migration at 50 uM after 24 hrs by Matrigel cell invasion assay | 2012 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5 | A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. |
| AID1298431 | Antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as Vif mutation at 50 uM incubated for 4 hrs prior to infection measured at 72 hrs post infection by illumina sequencing method (Rvb = 19.2%) | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID721442 | Antitumor activity against human HeLa cells assessed as growth inhibition measured after 48 hrs by MTT assay | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Bioactive barrigenol type triterpenoids from the leaves of Xanthoceras sorbifolia Bunge. |
| AID359522 | Effect on matrix metalloprotease 10 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID637953 | Antibacterial activity against CagA-deficient Helicobacter pylori G21b isolated from chronic gastritis patient after 48 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1057861 | Inhibition of RML prion protein infected in mouse dividing ScN2a-cl3 cells expressing full length mouse PrP assessed as reduction of PrPsc level after 5 days by Western blotting analysis | 2013 | Bioorganic & medicinal chemistry, Dec-15, Volume: 21, Issue:24 | Antiprion compounds that reduce PrP(Sc) levels in dividing and stationary-phase cells. |
| AID359538 | Effect on transforming growth factor beta receptor 2 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID718776 | Inhibition of amyloid beta (1-42) aggregation at 20 uM after 24 hrs by transmission electron microscopy | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Design, synthesis, and evaluation of resveratrol derivatives as Aß(₁-₄₂) aggregation inhibitors, antioxidants, and neuroprotective agents. |
| AID1362651 | Disaggregation of Cu2+ induced amyloid beta (1 to 40) preformed fibrils assessed as aggregation level at 100 uM after 4 days by UV-visible turbidity method (Rvb = 143.11 +/- 0.76%) | |||
| AID481128 | Displacement of FITC-conjugated BH3-Bak peptide from human recombinant Bcl-XL expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assay | 2010 | Journal of medicinal chemistry, May-27, Volume: 53, Issue:10 | Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention. |
| AID1261081 | Selectivity ratio of IC50 for HEK293 cells to IC50 for human MCF7 cells | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Inhibitory effect of cytotoxic stilbenes related to resveratrol on the expression of the VEGF, hTERT and c-Myc genes. |
| AID568508 | Cytotoxicity against mouse Hepa-1c1c7 cells after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties. |
| AID1485922 | Metal chelating activity assessed as inhibition of Cu2+-induced amyloid beta (1 to 42 residues) aggregation by measuring reduction in amyloid fibrils at 50 uM after 2 mins by uranyl acetate staining based transmission electron microscopic analysis | 2017 | Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14 | Synthesis and pharmacological evaluation of novel chromone derivatives as balanced multifunctional agents against Alzheimer's disease. |
| AID1332999 | Antioxidant activity in CCL4-intoxicated Wistar albino rat assessed as liver cytosolic glutathione peroxidase activity per mg protein at 100 mg/kg, ip administered for 7 consecutive days after DL-alpha-tocopherol acetate treatment followed by CCL4 dosing | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and evaluation of in vivo antioxidant, in vitro antibacterial, MRSA and antifungal activity of novel substituted isatin N-(2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyl)thiosemicarbazones. |
| AID1309170 | Inhibition of Cu2+-amyloid beta (1 to 40) catalyzed generation of hydroxyl radical assessed as rate of radical formation per min at 2 equiv preincubated for 1 hr followed by CCA addition measured over 60 mins by CCA based fluorescence assay (Rvb = 13 +/- | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Ionophoric polyphenols selectively bind Cu(2+), display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila. |
| AID359333 | Effect on colony stimulating factor 3 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID738191 | Inhibition of NFkappaB signaling pathway in human HeLa cells assessed as inhibition of PMA induced luciferase treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID641065 | Antihyperglycemic activity in ddY mouse assessed as inhibition of sucrose-induced increase in plasma glucose level at 200 mg/kg, po administered 30 mins before sucrose challenge measured after 1 hr (Rvb = 221.4 +/- 9.1 mg/dl) | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Antidiabetogenic oligostilbenoids and 3-ethyl-4-phenyl-3,4-dihydroisocoumarins from the bark of Shorea roxburghii. |
| AID1632202 | Cytotoxicity against human DU145 cells after 72 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18 | Synthesis and anticancer activity of a hydroxytolan series. |
| AID1533724 | Inhibition of human CYP1A1 using ethoxyresorufin as substrate by MROD assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Phytoestrogens and their synthetic analogues as substrate mimic inhibitors of CYP1B1. |
| AID1609871 | Induction of apoptosis in human HuH7 cells assessed as increase in late apoptotic cells at 100 uM incubated for 48 hrs by annexin V and 7-AAD staining based assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Review about the multi-target profile of resveratrol and its implication in the SGK1 inhibition. |
| AID1896330 | Activation of human N-terminal hexa-histidine tagged SIRT1 expressed in Escherichia coli BL21 (DE3) using peptide substrate by fluorescence polarization assay relative to control | 2022 | Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21 | The Pursuit of Enzyme Activation: A Snapshot of the Gold Rush. |
| AID641061 | Antihyperglycemic activity in ddY mouse assessed as inhibition of sucrose-induced increase in plasma glucose level at 100 mg/kg, po administered 30 mins before sucrose challenge measured after 0.5 hrs (Rvb = 220.5 +/- 16.9 mg/dl) | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Antidiabetogenic oligostilbenoids and 3-ethyl-4-phenyl-3,4-dihydroisocoumarins from the bark of Shorea roxburghii. |
| AID416679 | Cytotoxicity against human PC3 cells after 72 hrs by MTT assay | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Synthesis and biological evaluation of cytotoxic properties of stilbene-based resveratrol analogs. |
| AID642337 | Inhibition of TNFalpha-activated NF-kappaB expressed in HEK293 cells at 50 uM by luciferase reporter gene assay | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets. |
| AID1298373 | Potentiation of 5-Aza-C-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as reduction in viral infectivity at 50 uM preincubated for 2 to 8 hrs followed by 5-Aza-C addition for 2 hrs and subsequen | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID697845 | Inhibition of amyloid beta (1 to 40) aggregation assessed as induction of disaggregation at 10 uM treated 24 hrs after formation of aggregates by thioflavin T fluorescence method | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22 | Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. |
| AID359301 | Effect on bone morphogenetic protein 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1347860 | Growth inhibition of mouse B16 cells at 25 uM after 48 hrs by SRB assay relative to control | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, synthesis and evaluation of novel dihydrostilbene derivatives as potential anti-melanogenic skin-protecting agents. |
| AID359097 | Antiapoptotic activity against osteoblasts in ovariectomized Wistar rat at 10 mg/kg after 10 weeks | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1371372 | Cytotoxicity against human A549 cells assessed as decrease in cell viability after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID1362643 | Inhibition of Cu2+ induced amyloid beta (1 to 40) fibril aggregation assessed as aggregation level at 100 uM measured on day 10 by UV-visible turbidity method (Rvb = 100 +/- 8.72%) | |||
| AID1566055 | Cytotoxicity against human SKOV3 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2). |
| AID359326 | Effect on procollagen 15 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID726362 | Antioxidant activity assessed as DPPH radical scavenging activity at 300 uM after 30 mins by spectrophotometry | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Antioxidant activities of thiosemicarbazones from substituted benzaldehydes and N-(tetra-O-acetyl-β-D-galactopyranosyl)thiosemicarbazide. |
| AID1225529 | Reduction in Bcl2 expression in prostate tissue in BPH-induced Sprague-Dawley rat model at 1 mg/kg, ip daily for 4 weeks by Western blot analysis | 2015 | Journal of natural products, Apr-24, Volume: 78, Issue:4 | Effects of resveratrol on benign prostatic hyperplasia by the regulation of inflammatory and apoptotic proteins. |
| AID359103 | Antitumor activity against human MCF7 cells xenografted in SCID mouse orthotropic model assessed as inhibition of 17beta estradiol-induced tumor weight at 10 mg/kg for 2 days | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1298433 | Antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as Nef mutation at 50 uM incubated for 4 hrs prior to infection measured at 72 hrs post infection by illumina sequencing method (Rvb = 22.6%) | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID370920 | Inhibition of COX2 | 2009 | Bioorganic & medicinal chemistry, Feb-01, Volume: 17, Issue:3 | Synthesis and biological evaluation of a library of resveratrol analogues as inhibitors of COX-1, COX-2 and NF-kappaB. |
| AID359070 | Increase in proliferation of mouse MC3T3-E1 cells assessed as fraction of cells in S phase at 0.1 to 10 uM after 24 hr by flow cytometry | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1878979 | Downregulation of miR-190a-5p expression in TGF-beta induced C57/B6J mouse primary hepatocytes at 10 to 50 uM incubated for 4 hrs by qRT-PCR analysis | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID491523 | Antioxidant activity assessed as nitric oxide scavenging activity at 60 uM | 2010 | Journal of medicinal chemistry, Jul-08, Volume: 53, Issue:13 | Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. |
| AID468427 | AUC in intragastrically dosed rat assessed as resveratrol disulfate level at 0.09 mmol/kg after 10 mins | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | Soluble polyphenols: synthesis and bioavailability of 3,4',5-tri(alpha-D-glucose-3-O-succinyl) resveratrol. |
| AID1385434 | Inhibition of NFkappaB in mouse RAW 264.7 cells assessed as reduction in LPS induced NO production at 10 uM after 24 hrs by Griess assay relative to control | 2018 | Journal of medicinal chemistry, 09-27, Volume: 61, Issue:18 | Novel Hybrid Conjugates with Dual Suppression of Estrogenic and Inflammatory Activities Display Significantly Improved Potency against Breast Cancer. |
| AID637959 | Antibacterial activity against CagA-deficient Helicobacter pylori G204 isolated from chronic gastritis patient after 48 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1311760 | Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as TNFalpha levels at 5 umol/L by ELISA (Rvb = 183.21 +/- 5.36 pg/mL) | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata. |
| AID359546 | Effect on vascular endothelial growth factor C gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID418722 | Cytotoxicity against mouse Hepa-1c1c7 cells after 72 hrs by sulforhodamine B assay | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7 | Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. |
| AID1352498 | Inhibition of LPS-induced TNF-alpha production in rat RAW264.7 cells at 10 uM after 24 hrs by ELISA | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Alkylated resveratrol prodrugs and metabolites as potential therapeutics for neurodegenerative diseases. |
| AID738192 | Inhibition of AP1 signaling pathway in human HeLa cells assessed as inhibition of PMA induced luciferase at 100 uM treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID1264954 | Cytotoxicity against human MSC assessed as cell viability at 5 uM treated for 3 days measured on day 4 by alamar blue assay (Rvb = 97 to 100%) | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11 | Defining Key Structural Determinants for the Pro-osteogenic Activity of Flavonoids. |
| AID510191 | Antitumor activity against human MDA-MB-231 cells after 6 days by SRB assay | 2010 | Bioorganic & medicinal chemistry, Sep-15, Volume: 18, Issue:18 | Synthesis of heterocycle-based analogs of resveratrol and their antitumor and vasorelaxing properties. |
| AID1395903 | Inhibition of DPP4 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 4 secs followed by substrate addition and measured after 30 mins by luminescence assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus. |
| AID595054 | Inhibition of bovine brain tubulin polymerization after 20 mins by turbidimetry | 2011 | Bioorganic & medicinal chemistry, Apr-15, Volume: 19, Issue:8 | Synthesis, biological evaluation, and molecular docking studies of resveratrol derivatives possessing chalcone moiety as potential antitubulin agents. |
| AID320801 | Inhibition of beta amyloid 25-35 fibril formation at 10 uM | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2 | New polyphenols active on beta-amyloid aggregation. |
| AID1430689 | Apparent intrinsic clearance in human hepatocytes assessed per million cells at 5 uM by LC-MS/MS analysis | 2017 | ACS medicinal chemistry letters, May-11, Volume: 8, Issue:5 | Toward Resolving the Resveratrol Conundrum: Synthesis and |
| AID1552787 | Neuroprotective activity against TBHP-induced cellular damage in rat PC12 cells assessed as cell viability at 10 uM pretreated for 1 hr followed by TBHP addition and measured after 3 hrs by CCK8 assay (Rvb = 27.3%) | 2019 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 29, Issue:17 | Comparative analysis of stilbene and benzofuran neolignan derivatives as acetylcholinesterase inhibitors with neuroprotective and anti-inflammatory activities. |
| AID639324 | Antibacterial activity against CagA-expressing Helicobacter pylori SI10 isolated from chronic gastritis patient after 24 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID481676 | Induction of human ApoA-1 gene expression in human Caco-2 cells co-transfected with luc-beta-galactosidase at 15 uM after 48 hrs assessed as luciferase activity by luminometer relative to control | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5 | Stilbene analogs as inducers of apolipoprotein-I transcription. |
| AID1611506 | Thermal stability of compound in DMSO/methanol assessed as mass loss by UV spectroscopic method | 2019 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 29, Issue:24 | Synthesis and evaluation of 1,3,5-triazine derivatives as sunscreens useful to prevent skin cancer. |
| AID755112 | Cytotoxicity against human Huh7.5.1 cells after 72 hrs | 2013 | Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13 | Semisynthesis, cytotoxicity, antiviral activity, and drug interaction liability of 7-O-methylated analogues of flavonolignans from milk thistle. |
| AID730568 | Antinociceptive activity in Swiss mouse assessed as inhibition of capsaicin-induced spontaneous nociception at 200 ug/site, administered as intraplantarly | 2013 | Journal of natural products, Jan-25, Volume: 76, Issue:1 | Evidence for the analgesic activity of resveratrol in acute models of nociception in mice. |
| AID359305 | Effect on bone morphogenetic protein 6 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID735925 | Activation of N-terminal His6-tagged SIRT1 (156 to 664 amino acid residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using ac-RHKKac-AMC as substrate after 45 mins by fluorometric analysis | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate. |
| AID1573650 | Activation of Nrf2 in rat HBZY-1 cells assessed as increase in GCLC level at 6 uM by Western blot analysis | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and biological evaluation of bifendate derivatives bearing acrylamide moiety as novel antioxidant agents. |
| AID1298392 | Effect on dRGU-TP level in human U373-MAGI cells at 200 uM preincubated for 2 hrs followed by 5-aza-dC addition measured after 4 hrs by LC-MS/MS analysis | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1298418 | Potentiation of 5-Aza-dC-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as reduction in gag level at 50 uM after 2 to 72 hrs by qPCR method | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1333791 | Cytotoxicity against human L02 cells assessed as cell growth inhibition at 100 uM after 48 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1 | Synthesis and bioactivity evaluation of 2,3-diaryl acrylonitrile derivatives as potential anticancer agents. |
| AID634525 | Antioxidant activity in ethyl alcohol assessed as trolox equivalents of ABTS radical scavenging activity after 6 mins by TEAC assay | 2011 | Bioorganic & medicinal chemistry, Dec-15, Volume: 19, Issue:24 | Synthesis and study of new paramagnetic resveratrol analogues. |
| AID1332998 | Antioxidant activity in CCL4-intoxicated Wistar albino rat assessed as liver cytosolic superoxide dismutase activity per mg protein at 100 mg/kg, ip administered for 7 consecutive days after DL-alpha-tocopherol acetate treatment followed by CCL4 dosing me | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and evaluation of in vivo antioxidant, in vitro antibacterial, MRSA and antifungal activity of novel substituted isatin N-(2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyl)thiosemicarbazones. |
| AID595053 | Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry, Apr-15, Volume: 19, Issue:8 | Synthesis, biological evaluation, and molecular docking studies of resveratrol derivatives possessing chalcone moiety as potential antitubulin agents. |
| AID1261093 | Down regulation of VEGF gene expression in human MCF7 cells at 10 ug/mL after 48 hrs by RT-qPCR analysis relative to control | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Inhibitory effect of cytotoxic stilbenes related to resveratrol on the expression of the VEGF, hTERT and c-Myc genes. |
| AID719278 | Inhibition of mushroom tyrosinase using L-tyrosine as substrate at 10 uM after 30 mins by spectrophotometric analysis | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis of novel azo-resveratrol, azo-oxyresveratrol and their derivatives as potent tyrosinase inhibitors. |
| AID255902 | Inhibitory concentration required for antiproliferative activity against human MDA-MB-231 cells | 2005 | Journal of medicinal chemistry, Nov-03, Volume: 48, Issue:22 | Synthesis of a resveratrol analogue with high ceramide-mediated proapoptotic activity on human breast cancer cells. |
| AID1336831 | Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins under dark condition | 2017 | Bioorganic & medicinal chemistry, 02-01, Volume: 25, Issue:3 | Quinolines: Microwave-assisted synthesis and their antifungal, anticancer and radical scavenger properties. |
| AID359184 | Inhibition of [14C]dehydroascorbic acid uptake in human U937 cells at 38 uM by scintillation spectrometry in presence of buffer containing NaCl and Na2HPO4 | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3 | Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells. |
| AID1362754 | Immunomodulatory activity in LPS-stimulated mouse RAW264.7 cells assessed as decrease in CD86 expression at 50 uM incubated with LPS for 1 hr followed by compound addition measured after 24 hrs by flow cytometry | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues. |
| AID1611500 | Antioxidant activity assessed as DPPH free radical scavenging activity at 400 uM incubated for 60 mins by spectrophotometric method relative to control | 2019 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 29, Issue:24 | Synthesis and evaluation of 1,3,5-triazine derivatives as sunscreens useful to prevent skin cancer. |
| AID762884 | Induction of SIRT1-mediated TFAM expression in H2O2-induced HUVEC pretreated for 1 day followed by compound washout and H2O2-treatment measured after 10 days by RT-PCR analysis | 2013 | Journal of natural products, Jul-26, Volume: 76, Issue:7 | trans-Resveratrol in Gnetum gnemon protects against oxidative-stress-induced endothelial senescence. |
| AID1770510 | Cytotoxicity against human MCF7 cells assessed as release of LDH up to 250 uM measured after 24 hrs by lactate dehydrogenase assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis, structure-activity relationships and molecular docking studies of phenyldiazenyl sulfonamides as aromatase inhibitors. |
| AID1676794 | Induction of membrane perturbation in DC20:1PC LUV bilayer assessed as fluorescence quench rate by measuring gramicidin mixture monomer to dimer equilibrium at 30 uM by fluorescence quenching assay | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20 | Assessing the Perturbing Effects of Drugs on Lipid Bilayers Using Gramicidin Channel-Based |
| AID1062128 | Reduction in fimbriae production in Escherichia coli O157:H7 biofilm grown on nylon filter at 20 ug/ml after 24 hrs by scanning electron microscopy | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1 | Resveratrol oligomers inhibit biofilm formation of Escherichia coli O157:H7 and Pseudomonas aeruginosa. |
| AID1333802 | Cell cycle arrest in human HeLa cells assessed as accumulation at G0/G1 phase at 50 uM after 24 hrs by propidium iodide-based FACS analysis (Rvb = 61.71%) | 2017 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1 | Synthesis and bioactivity evaluation of 2,3-diaryl acrylonitrile derivatives as potential anticancer agents. |
| AID738206 | Cytotoxicity against african green monkey Vero cells assessed as growth inhibition measured after 48 hrs by XTT assay | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID455030 | Cytotoxicity against mouse P388 cells after 48 hrs by sulforhodamine B assay | 2009 | Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18 | E-Combretastatin and E-resveratrol structural modifications: antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes. |
| AID1407185 | Antioxidant activity assessed as ABTS radical cation scavenging activity by measuring trolox equivalent antioxidant capacity measured at 6 mins | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties. |
| AID1083156 | Antifungal activity against Diplodia seriata LAT28 assessed as growth inhibition measured after 1 to 10 days | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID610302 | Reduction in Escherichia coli count in C57BL/6J mouse distal colon mucosa with DSS-induced colon inflammation at 2.1 mg/kg/day, po for 21 days followed by compound dosing for 8 days co-administered with DSS followed by 2.1 mg/kg/day, po dosing for 6 days | 2010 | Journal of medicinal chemistry, Oct-28, Volume: 53, Issue:20 | Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents. |
| AID359557 | Inhibition of antiapoptotic activity in rat primary osteoblast cells at 1 uM after 48 hrs in presence of BMP2-specific neutralizing antibody | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1281399 | Cytotoxicity against human MDA-MB-468 cells after 96 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Non-symmetrical furan-amidines as novel leads for the treatment of cancer and malaria. |
| AID377456 | Estrogenic activity in human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 100 pM estradiol by alamar blue assay | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3 | Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines. |
| AID1879023 | Antifibrotic activity in CCL-4 induced liver fibrosis C57/B6J mouse model transfected with miR-190a-5p agomir assessed as reduction in miR-190a-5p expression in liver at 100 mg/kg/day, ip measured after 72 hrs post last dose by qRT-PCR analysis | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID1298407 | Potentiation of 5-Aza-C-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as increase in total mutation frequency at 50 uM incubated for 4 hrs preinfection followed by 5-Aza-C addition for 2 hrs pr | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1884065 | Antibacterial activity against Clostridium difficile CECT531 incubated for 24 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID359530 | Effect on runt related transcription factor 2 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1309191 | Induction of self-induced amyloid beta (1 to 40) (unknown origin) fibril aggregation at 100 uM after 3 days by turbidity assay | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Ionophoric polyphenols selectively bind Cu(2+), display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila. |
| AID1371386 | Cytotoxicity against human BxPC3 cells assessed as cell viability at 16 uM after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID359300 | Effect on biglycan gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID759449 | Induction of disaggregation of self-mediated amyloid beta (1 to 42) fibril (unknown origin) at 25 uM after 24 hrs by transmission electron microscopic analysis | 2013 | Journal of medicinal chemistry, Jul-25, Volume: 56, Issue:14 | Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease. |
| AID1632224 | Selectivity index, ratio of CD50 against human MHRF cells to CD50 for human DU145 cells after 72 hrs | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18 | Synthesis and anticancer activity of a hydroxytolan series. |
| AID692955 | Inhibition of LiCl-induced Wnt/beta-casein in human HEK293T cells transfected with TOP Flash assessed as decrease in luciferase expression at 100 uM after 12 hrs by dual luciferase reporter assay | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID359177 | Inhibition of 2-[1,2-3H(N)]deoxy-D-glucose uptake in human HL60 cells by scintillation spectrometry in presence of sodium-free buffer | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3 | Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells. |
| AID359318 | Effect on procollagen 10alpha 1 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID610241 | Antiinflammatory activity in C57BL/6J mouse model of DSS-induced colon inflammation assessed as reduction of colon IL6 level at 2.1 mg/kg/day, po for 21 days followed by compound dosing for 8 days co-administered with DSS followed by 2.1 mg/kg/day, po dos | 2010 | Journal of medicinal chemistry, Oct-28, Volume: 53, Issue:20 | Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents. |
| AID416364 | Cytotoxicity against human HL60 cells at 10 uM after 48 hrs by MTT assay | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6 | 4,4'-Dihydroxy-trans-stilbene, a resveratrol analogue, exhibited enhanced antioxidant activity and cytotoxicity. |
| AID510192 | Vasorelaxant activity in Wistar rat aortic rings assessed as reduction in KCL-induced contractile tone | 2010 | Bioorganic & medicinal chemistry, Sep-15, Volume: 18, Issue:18 | Synthesis of heterocycle-based analogs of resveratrol and their antitumor and vasorelaxing properties. |
| AID1494288 | Antioxidant activity assessed as AAPH radical scavenging activity by measuring trolox equivalent at 10 to 20 uM preincubated for 10 mins followed by AAPH addition measured every min for 120 mins by ORAC-FL assay | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5 | Design, Synthesis, and Evaluation of Orally Bioavailable Quinoline-Indole Derivatives as Innovative Multitarget-Directed Ligands: Promotion of Cell Proliferation in the Adult Murine Hippocampus for the Treatment of Alzheimer's Disease. |
| AID614625 | Cytotoxicity against HEK293 cells assessed as decrease in cell viability at 100 uM after 48 hrs by MTT assay relative to control | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18 | Chemical modifications of resveratrol for improved protein kinase C alpha activity. |
| AID1371456 | Cmax in mouse at 100 mg/kg, po by HPLC method | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23 | Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. |
| AID468426 | AUC in intragastrically dosed rat assessed as resveratrol glucuronide level at 0.09 mmol/kg after 10 mins | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | Soluble polyphenols: synthesis and bioavailability of 3,4',5-tri(alpha-D-glucose-3-O-succinyl) resveratrol. |
| AID1062139 | Antibiofilm activity against Escherichia coli O157:H7 assessed as repression of csgA expression at 20 ug/ml after 5 hrs by qRT-PCR analysis | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1 | Resveratrol oligomers inhibit biofilm formation of Escherichia coli O157:H7 and Pseudomonas aeruginosa. |
| AID1450150 | Growth inhibition of human MCF7 cells after 2 days by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11 | One drug for two targets: Biological evaluation of antiretroviral agents endowed with antiproliferative activity. |
| AID1502973 | Reduction in total cholesterol in swine with metabolic syndrome and myocardial ischemia | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Lipid lowering agents of natural origin: An account of some promising chemotypes. |
| AID1256178 | Antibacterial activity in Chromobacterium violaceum CV026 for 16 hrs | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | The quorum-sensing inhibiting effects of stilbenoids and their potential structure-activity relationship. |
| AID697846 | Inhibition of amyloid beta (1 to 40) aggregation assessed as induction of disaggregation at 100 uM treated 24 hrs after formation of aggregates by thioflavin T fluorescence method | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22 | Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. |
| AID1168365 | Hepatoprotective activity against isoniazid-rifampicin induced liver injury in BALB/c mouse assessed as restoration of SIRT1 mRNA level at 100 mg/kg, po bid for 3 days starting 30 mins prior isoniazid-rifampicin administration measured 24 hrs post-last do | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. |
| AID1298263 | Potentiation of 5-Aza-C-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as 5-Aza-C EC50 at 50 uM preincubated for 2 hrs followed by 5-Aza-C addition for 2 hrs and subsequent viral infection measu | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1494290 | Inhibition of amyloid beta (1 to 42) (unknown origin) self-induced aggregation at 5 uM after 48 hrs by thioflavin-T fluorescence assay relative to control | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5 | Design, Synthesis, and Evaluation of Orally Bioavailable Quinoline-Indole Derivatives as Innovative Multitarget-Directed Ligands: Promotion of Cell Proliferation in the Adult Murine Hippocampus for the Treatment of Alzheimer's Disease. |
| AID1420923 | Antibacterial activity against Campylobacter jejuni after 17 hrs by NCCLS broth microdilution method | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Antibacterial and antioxidant activities for natural and synthetic dual-active compounds. |
| AID1879005 | Inhibition of TGF-beta1 induced apoptosis in C57/B6J mouse primary hepatocytes assessed as late apoptotic cells by Annexin-V-FITC-H and PI staining based flow cytometry analysis (Rvb = 12.03 %) | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID359053 | Reversal of induction of FOXO3a activity in human MDA-MB-231 cells transfected with FOXO3a-specific small interfering RNA | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID692951 | Inhibition of Wnt/beta-casein in human LS174T cells assessed as increase in p21WAF1/CIP1 protein level at 100 uM by Western blotting | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID1888431 | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by DTNB-reagent based Ellman's method | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Design, synthesis, and biological evaluation of novel (4-(1,2,4-oxadiazol-5-yl)phenyl)-2-aminoacetamide derivatives as multifunctional agents for the treatment of Alzheimer's disease. |
| AID1772551 | Toxicity in 3hpf zebrafish AB embryo assessed as NOAEL measured 96 hpf | 2021 | European journal of medicinal chemistry, Nov-05, Volume: 223 | Silyl resveratrol derivatives as potential therapeutic agents for neurodegenerative and neurological diseases. |
| AID468425 | AUC in intragastrically dosed rat assessed as resveratrol sulfate level at 0.09 mmol/kg after 10 mins | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | Soluble polyphenols: synthesis and bioavailability of 3,4',5-tri(alpha-D-glucose-3-O-succinyl) resveratrol. |
| AID359080 | Increase in osteocalcin mRNA levels in human MG63 cells at 1 uM after 72 hrs by RT-PCR | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1083163 | Antifungal activity against Botryosphaeria dothidea OGE14 assessed as growth inhibition measured after 1 to 10 days relative to control | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID299632 | Neuronal differentiation activity assessed as increase in number of neurons at 0.1 uM in relative to control | 2007 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15 | Dual bioactivity of resveratrol fatty alcohols: differentiation of neural stem cells and modulation of neuroinflammation. |
| AID1298354 | Antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as increase in frequency of T to C transversion at 50 uM incubated for 4 hrs prior to infection measured at 72 hrs post infection by illumina sequencing me | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID610399 | Antiinflammatory activity in human CCD-18Co cells assessed inhibition of IL1beta-induced PGE2 production at 1 uM after 18 hrs | 2010 | Journal of medicinal chemistry, Oct-28, Volume: 53, Issue:20 | Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents. |
| AID692945 | Inhibition of Wnt/beta-casein in human LS174T cells assessed as reduction in Ki67 mRNA level at 100 uM after 36 hrs by RT-PCR analysis | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID1317151 | Oral bioavailability in rat at 50 or 150 mg/kg/day administered through gavage for 14 consecutive days by HPLC analysis | 2016 | European journal of medicinal chemistry, Aug-25, Volume: 119 | How much successful are the medicinal chemists in modulation of SIRT1: A critical review. |
| AID1435567 | Inhibition of recombinant full length LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE) using H3K4me2 substrate by fluorescence assay | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Discovery of resveratrol derivatives as novel LSD1 inhibitors: Design, synthesis and their biological evaluation. |
| AID1372023 | Antioxidant activity assessed as Trolox equivalents of photolysis-induced superoxide anion scavenging activity using CYPMPO spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID692975 | Inhibition of Wnt/beta-casein in human LS 174T cells assessed as reduction in pygopus2 protein level at 100 uM by Western blotting | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID1309179 | Inhibition of self-induced amyloid beta (1 to 40) (unknown origin) fibril aggregation assessed as remaining fibril aggregates at 100 uM after 7 days at pH 6.60 by thioflavin-T fluorescence assay | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Ionophoric polyphenols selectively bind Cu(2+), display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila. |
| AID271284 | Inhibition of COX2 assessed as LPS-stimulated PGE2 production in human whole blood leukocyte | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17 | Selective COX-2 inhibitors. Part 1: synthesis and biological evaluation of phenylazobenzenesulfonamides. |
| AID1220765 | Cmax in C57BL/6 mouse at 15 mg/kg administered intraarterially by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Oct, Volume: 40, Issue:10 | In vivo-formed versus preformed metabolite kinetics of trans-resveratrol-3-sulfate and trans-resveratrol-3-glucuronide. |
| AID1298323 | Reduction in dCTP level in human U373-MAGI cells at 50 uM preincubated for 2 hrs followed by 5-aza-C addition measured after 4 hrs by LC-MS/MS analysis | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID349547 | Activation of human SIRT1 expressed in Escherichia coli BL21 (DE3) assessed as concentration required to increase 50% enzyme activity by fluorescence polarization assay | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8 | Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators. |
| AID491613 | Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW 264.7 cells pretreated 30 mins before LPS challenge measured after 20 hrs by Griess reaction method relative to control | 2010 | Journal of medicinal chemistry, Jul-08, Volume: 53, Issue:13 | Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. |
| AID1256164 | Inhibition of Quorum sensing system in Pseudomonas aeruginosa PAO1 assessed as inhibition of swarming motility at 100 uM after 16 hrs | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | The quorum-sensing inhibiting effects of stilbenoids and their potential structure-activity relationship. |
| AID1420924 | Antibacterial activity against Campylobacter coli after 17 hrs by NCCLS broth microdilution method | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Antibacterial and antioxidant activities for natural and synthetic dual-active compounds. |
| AID1311768 | Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as PGE2 levels at 50 umol/L by ELISA (Rvb = 33.2 +/- 2.33 pg/mL) | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata. |
| AID264590 | Antiproliferative activity against MDR human HL60R cell line | 2006 | Journal of medicinal chemistry, May-18, Volume: 49, Issue:10 | Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. |
| AID603318 | Inhibition of human CD38 using 20 uM 1, N6-etheno NAD+ as substrate by continuous fluorimetric method | 2011 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 21, Issue:13 | Flavonoids as inhibitors of human CD38. |
| AID713103 | Inhibition of mushroom tyrosinase-mediated L-tyrosine oxidation assessed as decrease in dopachrome formation at 100 uM after 60 mins by UV-vis spectrophotometric analysis | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID1298293 | Reduction in dGTP level in human U373-MAGI cells at 200 uM after 6 hrs by LC-MS/MS analysis | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1140472 | Inhibition of amyloid beta (1 to 42) (unknown origin) self-aggregation at 20 uM after 46 to 48 hrs by thioflavin T based fluorometric assay | 2014 | Bioorganic & medicinal chemistry letters, May-15, Volume: 24, Issue:10 | Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer's disease. |
| AID1771670 | Inhibition of ultraviolet B-irradiation upregulated of prostaglandin E2 production in human HaCaT cells measured after 2 hrs by ELISA | 2021 | Journal of natural products, 09-24, Volume: 84, Issue:9 | Salicinoyl Quinic Acids and Their Prostaglandin E |
| AID1770524 | Inhibition of human aromatase using dibenzylfluorescein as a substrate preincubated with NADPH regenerating system for 10 mins followed by substrate addition incubated for 30 mins by fluorescence based analysis | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthesis, structure-activity relationships and molecular docking studies of phenyldiazenyl sulfonamides as aromatase inhibitors. |
| AID1570238 | Inhibition of human 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate at 10 uM preincubated for 15 mins followed by substrate addition by HPLC analysis relative to control | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors. |
| AID1311917 | Inhibition of self-induced aggregation of amyloid beta (1 to 42) (unknown origin) at 20 uM measured after 46 to 48 hrs by ThT-based fluorometric assay | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18 | Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin. |
| AID432238 | Inhibition of phagocytosis of FITC-conjugated Staphylococcus aureus 209P in mouse RAW264.7 cells using trypan blue staining after 80 mins by flow cytometry | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID1203640 | Inhibition of rat liver TrxR assessed as increase in absorbance at 50 uM by DTNB assay | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Design, synthesis, and biological evaluation of benzoselenazole-stilbene hybrids as multi-target-directed anti-cancer agents. |
| AID724580 | Binding affinity to planer lipid bilayer assessed as increase in anodic current by cyclic voltammetric analysis | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Dose-dependent interaction of trans-resveratrol with biomembranes: effects on antioxidant property. |
| AID650847 | Inhibition of TNF-alpha activated NF-kappaB expressed in HEK293 cells at 50 uM by luciferase reporter gene assay | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7 | Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol. |
| AID491620 | Cytotoxicity against human HEK293 cells at 34 uM | 2010 | Journal of medicinal chemistry, Jul-08, Volume: 53, Issue:13 | Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. |
| AID638158 | Bactericidal activity against CagA-expressing Helicobacter pylori SI10 isolated from chronic gastritis patient compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID724374 | Induction of morphological changes in human erythrocytes at => 60 uM after 1 hr by cold field emission scanning electron microscopic analysis | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Dose-dependent interaction of trans-resveratrol with biomembranes: effects on antioxidant property. |
| AID1519069 | Antimelanogenic activity against C57BL/6 mouse B16F10 cells at 10 uM incubated for 72 hrs relative to control | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | From bench to counter: Discovery and validation of a peony extract as tyrosinase inhibiting cosmeceutical. |
| AID634526 | Antioxidant activity in 0.05 M phosphate buffered saline assessed as trolox equivalents of ABTS radical scavenging activity after 6 mins by TEAC assay | 2011 | Bioorganic & medicinal chemistry, Dec-15, Volume: 19, Issue:24 | Synthesis and study of new paramagnetic resveratrol analogues. |
| AID1430669 | Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition at 30 uM after 72 hrs by CellTitre-Glo luminescent assay relative to control | 2017 | ACS medicinal chemistry letters, May-11, Volume: 8, Issue:5 | Toward Resolving the Resveratrol Conundrum: Synthesis and |
| AID692943 | Cytotoxicity against human LS 174T cells at 10 uM for 4 days by vi-cell cell viability analysis | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID1464283 | Cytotoxicity against mouse BV2 cells assessed as reduction in cell viability at 1 to 100 uM after 24 hrs in presence of LPS by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 27, Issue:20 | Natural neuro-inflammatory inhibitors from Caragana turfanensis. |
| AID293299 | Antioxidant activity in BALB/c mouse BM cells assessed as inhibition of ROS production | 2007 | Bioorganic & medicinal chemistry, Feb-15, Volume: 15, Issue:4 | Improved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems. |
| AID641066 | Antihyperglycemic activity in ddY mouse assessed as inhibition of sucrose-induced increase in plasma glucose level at 200 mg/kg, po administered 30 mins before sucrose challenge measured after 2 hrs (Rvb = 160.8 +/- 3.5 mg/dl) | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Antidiabetogenic oligostilbenoids and 3-ethyl-4-phenyl-3,4-dihydroisocoumarins from the bark of Shorea roxburghii. |
| AID1256183 | Decrease in rhIR gene expression in Pseudomonas aeruginosa PAO1 at 400 uM by RT-PCR analysis | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | The quorum-sensing inhibiting effects of stilbenoids and their potential structure-activity relationship. |
| AID432138 | Inhibition of phagocytosis of FITC-conjugated Escherichia coli K12 in human THP1 cells using trypan blue staining after 60 mins by flow cytometry | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID1543529 | Permeability of the compound in PBS/EtOH at 100 ug/ml after 10 hrs by PAMPA-BBB assay | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Synthesis and evaluation of tetrahydroisoquinoline-benzimidazole hybrids as multifunctional agents for the treatment of Alzheimer's disease. |
| AID639321 | Antibacterial activity against CagA-expressing Helicobacter pylori 328 isolated from chronic gastritis patient after 24 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID719271 | Inhibition of human aromatase activity after 30 mins by fluorescence analysis | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1). |
| AID164858 | Tested in vitro for the inhibition of protein-tyrosine kinase p56lck using angiotensin I (1.2 mM) and [gamma-32P]-ATP (50 pM) | 1993 | Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20 | Synthesis and protein-tyrosine kinase inhibitory activity of polyhydroxylated stilbene analogues of piceatannol. |
| AID264589 | Proapoptotic activity against human HL60 cell line | 2006 | Journal of medicinal chemistry, May-18, Volume: 49, Issue:10 | Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. |
| AID432146 | Inhibition of FSL-1-induced increase in phagocytosis of FITC-conjugated Escherichia coli K12 in human THP1 cells using trypan blue staining after 20 mins by flow cytometry | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID1372024 | Antioxidant activity assessed as Trolox equivalents of photolysis-induced singlet oxygen scavenging activity using 4-HO-TEMP spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID605943 | Activation of mitochondrial cytochrome C oxidase in human HaCaT lysate at 50 uM using equine cardiac cytochrome C substrate by spectrophotometry | 2011 | Journal of natural products, May-27, Volume: 74, Issue:5 | Glucosyloxybenzyl eucomate derivatives from Vanda teres stimulate HaCaT cytochrome c oxidase. |
| AID403718 | Cytotoxicity against human HepG2 cells after 48 hrs by acid phosphatase method | 2005 | Journal of natural products, Oct, Volume: 68, Issue:10 | Cytotoxic furostanol saponins and a megastigmane glucoside from tribulus parvispinus. |
| AID1237127 | Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production at 10 mM pre-incubated for 10 mins before LPS stimulation for 24 hrs by ELISA method | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15 | Design, synthesis and biological evaluation of paralleled Aza resveratrol-chalcone compounds as potential anti-inflammatory agents for the treatment of acute lung injury. |
| AID638059 | Antibacterial activity against CagA-expressing Helicobacter pylori 2Ca isolated from gastric carcinoma patient after 48 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1083161 | Antifungal activity against Neofusicoccum parvum PER20 assessed as growth inhibition measured after 1 to 10 days | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID273488 | Suppression of LPS-stimulated COX2 mRNA expression in mouse BV2 cells at 20 uM | 2006 | Journal of medicinal chemistry, Nov-30, Volume: 49, Issue:24 | Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB. |
| AID608338 | Antifungal activity against 1 x 10'4 cfu/mL Candida albicans ATCC 6258 after 48 hrs by NCCLS M38-P microtiter broth dilution method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis and antimicrobial evaluation of new benzofuran derivatives. |
| AID1362647 | Inhibition of self-induced amyloid beta (1 to 40) (unknown origin) fibril aggregation assessed as aggregation level at 100 uM measured on day 7 by UV-visible turbidity method (Rvb = 100 +/- 2.22%) | |||
| AID375991 | Antioxidant activity assessed as inhibition of 2,2'-azobis(2-amidinopropane)dihydrochloride-induced lipid peroxidation at 3.125 ug/ml by ferric thiocyanate system relative to control | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4 | Vanillic acid glycoside and quinic acid derivatives from Gardeniae Fructus. |
| AID1168370 | Hepatoprotective activity against isoniazid-rifampicin induced liver injury in BALB/c mouse assessed as change in SIRT6 mRNA level at 100 mg/kg, po bid for 3 days starting 30 mins prior isoniazid-rifampicin administration measured 24 hrs post-last dose of | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. |
| AID481132 | Binding affinity to Vaccinia virus recombinant N1L I6K mutant expressed in Escherichia coli BL21 (DE3) assessed as protein melting temperature at 214 uM by differential scanning calorimetry | 2010 | Journal of medicinal chemistry, May-27, Volume: 53, Issue:10 | Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention. |
| AID1879006 | Inhibition of TGF-beta1 induced apoptosis in C57/B6J mouse primary hepatocytes assessed as dead cells by Annexin-V-FITC-H and PI staining based flow cytometry analysis (Rvb = 3.68 %) | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID697853 | Inhibition of horse BChE at 2 mg/ml by Ellman's method | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22 | Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. |
| AID1467206 | Cytotoxicity against human ALL5 cells after 120 hrs by MTT method | 2017 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 27, Issue:12 | Activity of resveratrol triesters against primary acute lymphoblastic leukemia cells. |
| AID1362635 | Metal chelating activity assessed as inhibition of Cu2+ induced amyloid beta (1 to 40) aggregation by measuring decrease in ROS production at 2 equiv after 75 mins by fluorescence assay | |||
| AID638056 | Antibacterial activity against CagA-expressing Helicobacter pylori 4Cb isolated from gastric carcinoma patient after 48 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID639331 | Antibacterial activity against CagA-expressing Helicobacter pylori 18C7 isolated from gastric carcinoma patient after 24 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1420917 | Antibacterial activity against Bacillus cereus after 17 hrs by NCCLS broth microdilution method | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Antibacterial and antioxidant activities for natural and synthetic dual-active compounds. |
| AID359536 | Effect on transforming growth factor beta 3 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1533723 | Inhibition of human CYP1A1 using ethoxyresorufin as substrate by EROD assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Phytoestrogens and their synthetic analogues as substrate mimic inhibitors of CYP1B1. |
| AID1609872 | Induction of apoptosis in human HuH7 cells assessed as increase in necrotic cells at 100 uM incubated for 48 hrs by annexin V and 7-AAD staining based assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Review about the multi-target profile of resveratrol and its implication in the SGK1 inhibition. |
| AID1311918 | Antioxidant activity assessed as trolox equivalent of AAPH radical scavenging activity preincubated for 15 mins followed by AAPH addition measured every min for 120 mins by ORAC-FL assay | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18 | Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin. |
| AID738202 | Cytotoxicity against human HeLa cells assessed as growth inhibition measured at 100 uM after 48 hrs by XTT assay | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID418721 | Inhibition of aromatase after 30 mins by fluorescence assay | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7 | Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. |
| AID1083168 | Antifungal activity against Eutypa lata BX1-10 assessed as growth inhibition at 500 uM measured after 1 to 10 days relative to control | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID359543 | Effect on vitamin D receptor gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID697064 | Inhibition of duck liver FASN | 2011 | Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16 | The lipogenesis pathway as a cancer target. |
| AID719273 | Induction of quinone reductase-1 activity in mouse BPrc1 cells after 48 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1). |
| AID1383210 | Permeability of the compound after 10 hrs by PAMPA | 2018 | European journal of medicinal chemistry, Apr-10, Volume: 149 | Design, synthesis, and biological evaluation of compounds with a new scaffold as anti-neuroinflammatory agents for the treatment of Alzheimer's disease. |
| AID1264950 | Cytotoxicity against human MSC assessed as cell viability at 1 uM measured on day 1 by alamar blue assay (Rvb = 97 to 101%) | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11 | Defining Key Structural Determinants for the Pro-osteogenic Activity of Flavonoids. |
| AID1190482 | Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins by spectrophotometry | 2015 | Bioorganic & medicinal chemistry, Feb-01, Volume: 23, Issue:3 | Evaluation of two novel antioxidants with differential effects on curcumin-induced apoptosis in C2 skeletal myoblasts; involvement of JNKs. |
| AID491529 | Cytotoxicity against human KB cells assessed as cell survival at 20 ug/ml after 72 hrs by sulforhodamine B method | 2010 | Journal of medicinal chemistry, Jul-08, Volume: 53, Issue:13 | Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. |
| AID735492 | Activation of N-terminal His6-tagged SIRT1 (156 to 664 amino acid residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using ac-RHKKac-NH2 as substrate after 45 mins by fluorometric analysis | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate. |
| AID738183 | Inhibition of Ets signaling pathway in human HeLa cells assessed as measured as lowest concentration required 50 to 60 % inhibition of PMA induced luciferase treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID713097 | Inhibition of mushroom tyrosinase-mediated oxygen consumption at 100 uM using L-tyrosine substrate incubated 30 mins prior to substrate addition measured after 60 mins | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID123081 | the minimum inhibitory concentration (MIC) that inhibits all visible growth of the Micrococcus luteus (bacteria) at 64 ug/ml | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID1418627 | Metal chelating activity assessed as inhibition of Fe3+-induced amyloid beta (1 to 42 residues) fibrils at 50 uM after 24 hrs by uranyl acetate staining based transmission electron microscopic analysis | 2018 | Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22 | Resveratrol-maltol hybrids as multi-target-directed agents for Alzheimer's disease. |
| AID248171 | inhibitory concentration against PGE-2 production in LPS-stimulated RAW264.7 cells | 2004 | Bioorganic & medicinal chemistry letters, Dec-06, Volume: 14, Issue:23 | Synthesis and inhibitory effects of pinosylvin derivatives on prostaglandin E2 production in lipopolysaccharide-induced mouse macrophage cells. |
| AID349883 | Inhibition of amyloid beta (1-42) self-aggregation at 50 uM after 24 hrs by thioflavin T fluorescence method | 2009 | Journal of medicinal chemistry, May-14, Volume: 52, Issue:9 | Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease. |
| AID228461 | Inhibition of tubulin polymerization reported as IC50 | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID1884054 | Antibacterial activity against Bacillus cereus ATCC 10987 incubated for 20 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID1480843 | Antioxidant activity assessed as trolox equivalent of AAPH-induced radical scavenging activity at 5 uM pretreated for 15 mins followed by APPH challenge measured every minute for 240 mins by ORAC-FL assay | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment. |
| AID1430691 | Apparent intrinsic clearance in rat hepatocytes assessed per million cells at 5 uM by LC-MS/MS analysis | 2017 | ACS medicinal chemistry letters, May-11, Volume: 8, Issue:5 | Toward Resolving the Resveratrol Conundrum: Synthesis and |
| AID359075 | Reversal of increase in pBMP2 expression in mouse MC3T3-E1 cells transfected with dominant-negative mutant Src expression vector at 1 uM by luciferase method | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1888435 | Inhibition of NO production in LPS-induced mouse BV-2 cells pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Design, synthesis, and biological evaluation of novel (4-(1,2,4-oxadiazol-5-yl)phenyl)-2-aminoacetamide derivatives as multifunctional agents for the treatment of Alzheimer's disease. |
| AID638051 | Antibacterial activity against CagA-expressing Helicobacter pylori 10K isolated from gastric carcinoma patient after 48 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID404514 | Binding affinity to human serum albumin at 4 uM by fluorescence enhancing measurement | 2008 | Bioorganic & medicinal chemistry, Jun-15, Volume: 16, Issue:12 | Design, synthesis and spectroscopic studies of resveratrol aliphatic acid ligands of human serum albumin. |
| AID1306435 | Lipophilicity, log P of the compound | 2016 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 26, Issue:14 | Synthesis and skin gene analysis of 4'-acetoxy-resveratrol (4AR), therapeutic potential for dermal applications. |
| AID642331 | Induction of QR1 activity in mouse TAOc1 mutant Hepa cells using MTT as substrate assessed as induction ratio by spectrophotometry relative to control | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets. |
| AID654123 | Antioxidant activity assessed as concentration required to scavenge 50% superoxide anions after 10 mins by spectrophotometry | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8 | Free radical scavenging and antiproliferative properties of Biginelli adducts. |
| AID1884066 | Antibacterial activity against Clostridium-ihumii AP5 incubated for 24 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID359087 | Increase in osteopontin mRNA levels in rat primary osteoblast cells at 1 uM after 72 hrs by RT-PCR | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1571121 | Inhibition of self-induced aggregation of amyloid beta (1 to 42) (unknown origin) at 20 uM after 48 hrs by thioflavin T-based fluorescence method relative to control | 2018 | MedChemComm, Nov-01, Volume: 9, Issue:11 | Discovery of boron-containing compounds as Aβ aggregation inhibitors and antioxidants for the treatment of Alzheimer's disease. |
| AID359279 | Reversal of increase in DNA-binding activity of ERalpha in nuclear extracts of mouse MC3T3-E1 cells by electrophoretic mobility shift assays in presence of PP2 | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID388251 | Antiproliferative activity against human CNE2 cells after 72 hrs by MTT assay | 2008 | Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23 | The design, synthesis, and anti-tumor mechanism study of N-phosphoryl amino acid modified resveratrol analogues. |
| AID1385447 | Inhibition of NFkappaB in mouse RAW 264.7 cells assessed as reduction in LPS induced NO production at 10 uM after 24 hrs in presence of OBHS by Griess assay relative to control | 2018 | Journal of medicinal chemistry, 09-27, Volume: 61, Issue:18 | Novel Hybrid Conjugates with Dual Suppression of Estrogenic and Inflammatory Activities Display Significantly Improved Potency against Breast Cancer. |
| AID474871 | Antioxidant activity assessed as against AAPH-induced oxidative damage of pBR322 plasmid DNA assessed as single strand breakage at 10 uM by gel electrophoresis | 2010 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8 | Antioxidant and antiproliferative activities of hydroxyl-substituted Schiff bases. |
| AID1333803 | Cell cycle arrest in human HeLa cells assessed as accumulation at S phase at 50 uM after 24 hrs by propidium iodide-based FACS analysis (Rvb = 31.26%) | 2017 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1 | Synthesis and bioactivity evaluation of 2,3-diaryl acrylonitrile derivatives as potential anticancer agents. |
| AID634528 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced ROS production after 24 hrs using DCFH-DA by fluorescent microplate reader | 2011 | Bioorganic & medicinal chemistry, Dec-15, Volume: 19, Issue:24 | Synthesis and study of new paramagnetic resveratrol analogues. |
| AID1220766 | Tmax in C57BL/6 mouse at 15 mg/kg administered intraarterially by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Oct, Volume: 40, Issue:10 | In vivo-formed versus preformed metabolite kinetics of trans-resveratrol-3-sulfate and trans-resveratrol-3-glucuronide. |
| AID1632221 | Selectivity index, ratio of CD50 against human MHRF cells to CD50 for human DU145 cells after 48 hrs | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18 | Synthesis and anticancer activity of a hydroxytolan series. |
| AID349548 | Activation of human SIRT1 expressed in Escherichia coli BL21 (DE3) assessed as maximum activation of enzyme activity by fluorescence polarization assay | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8 | Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators. |
| AID359516 | Effect on MAD homolog 3 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID416358 | Inhibition of Fe(2+)/ascorbate-induced lipid peroxidation in human erythrocyte ghosts assessed as inhibition of malondialdehyde formation at 5 uM | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6 | 4,4'-Dihydroxy-trans-stilbene, a resveratrol analogue, exhibited enhanced antioxidant activity and cytotoxicity. |
| AID1772552 | Toxicity in 3hpf zebrafish AB embryo assessed as LOAEL measured 96 hpf | 2021 | European journal of medicinal chemistry, Nov-05, Volume: 223 | Silyl resveratrol derivatives as potential therapeutic agents for neurodegenerative and neurological diseases. |
| AID359106 | Increase in BMP2 mRNA levels in mouse MC3T3-E1 cells at 1 uM by RT-PCR method | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1178163 | In vitro photoprotection of the compound assessed as UVA to UVB ratio by Optometric 290S analyzer | 2014 | Bioorganic & medicinal chemistry, May-01, Volume: 22, Issue:9 | Synthesis, antioxidant and photoprotection activities of hybrid derivatives useful to prevent skin cancer. |
| AID1083155 | Antifungal activity against Diplodia seriata BoF99-1 assessed as growth inhibition measured after 1 to 10 days | 2012 | Journal of agricultural and food chemistry, Dec-05, Volume: 60, Issue:48 | Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family. |
| AID432153 | Inhibition of heat killed Escherichia coli K12-induced nuclear translocation of p65 element of NF-kappaB in HEK293 cells expressing TLR2 at 100 uM pretreated for 1 hr before 6 hrs heat killed bacterial stimulation by immunostaining method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID481136 | Binding affinity to Vaccinia virus recombinant N1L I6K mutant expressed in Escherichia coli BL21 (DE3) assessed as effect on enthalpy of protein unfolding at 214 uM by differential scanning calorimetry | 2010 | Journal of medicinal chemistry, May-27, Volume: 53, Issue:10 | Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention. |
| AID273485 | Antioxidant activity measured as ability to reduce ferric tripyridyltriazine complex at 15 uM by FRAP assay | 2006 | Journal of medicinal chemistry, Nov-30, Volume: 49, Issue:24 | Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB. |
| AID359174 | Inhibition of 2-[1,2-3H(N)]deoxy-D-glucose uptake in human U937 cells by Michaelis-Menten plot | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3 | Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells. |
| AID1062144 | Antibiofilm activity against Escherichia coli O157:H7 after 24 hrs by spectrophotometry | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1 | Resveratrol oligomers inhibit biofilm formation of Escherichia coli O157:H7 and Pseudomonas aeruginosa. |
| AID1420930 | Antibiofilm activity against methicillin-resistant Staphylococcus aureus at 100 ug/ml after 18 hrs by crystal violet staining-based method relative to control | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Antibacterial and antioxidant activities for natural and synthetic dual-active compounds. |
| AID293298 | Antioxidant activity assessed as inhibition of superoxide production by xanthine/xanthine oxidase method | 2007 | Bioorganic & medicinal chemistry, Feb-15, Volume: 15, Issue:4 | Improved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems. |
| AID1298439 | Potentiation of 5-Aza-dC-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as Gag mutation at 50 uM incubated for 4 hrs preinfection followed by 5-Aza-C addition for 2 hrs preinfection and subseque | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID1311776 | Inhibition of NFkappaB signaling pathway in LPS-stimulated mouse RAW264.7 cells assessed as protein levels at 25 umol/L by ELISA (Rvb = 1.23 +/- 0.06 pg/mL) | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata. |
| AID1884082 | Bactericidal activity against Enterococcus faecalis LMG 16003 at 128 uM measured upto 24 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID738178 | Inhibition of FoxO signaling pathway in human HeLa cells assessed as inhibition of luciferase at 100 uM treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID1879028 | Antifibrotic activity in CCL-4 induced liver fibrosis C57/B6J mouse model assessed as increase in albumin level in serum at 100 mg/kg/day, ip measured after 72 hrs post last dose by ELISA | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID1298400 | Reduction in dCTP level in human U373-MAGI cells at 200 uM preincubated for 2 hrs followed by 5-aza-dC addition measured after 4 hrs by LC-MS/MS analysis relative to 5-aza-dC | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID654117 | Antioxidant activity assessed as scavenging of DPPH at 34.4 uM up to 10 mins by spectrophotometry | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8 | Free radical scavenging and antiproliferative properties of Biginelli adducts. |
| AID638150 | Bactericidal activity against CagA-deficient Helicobacter pylori G12 isolated from chronic gastritis patient compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1424460 | Growth inhibition of human A549 cells | 2017 | European journal of medicinal chemistry, Dec-15, Volume: 142 | From bench (laboratory) to bed (hospital/home): How to explore effective natural and synthetic PAK1-blockers/longevity-promoters for cancer therapy. |
| AID697852 | Inhibition of electric eel AChE at 2 mg/ml by Ellman's method | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22 | Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. |
| AID1065383 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by microbroth dilution method | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Small azobenzene derivatives active against bacteria and fungi. |
| AID458140 | Antimicrobial activity against Streptococcus mutans KCTC 3065 at 50 ug/ml after 20 hrs by disk diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | The antimicrobial activity of compounds from the leaf and stem of Vitis amurensis against two oral pathogens. |
| AID692980 | Inhibition of Wnt/beta-casein in human HEK293T cells transfected with TOP Flash assessed as decrease in luciferase expression at 100 uM after 12 hrs by dual luciferase reporter assay | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID639239 | Antibacterial activity against CagA-deficient Helicobacter pylori G50 isolated from chronic gastritis patient after 24 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID359508 | Effect on integrin alpha 2 gene expression in rat primary osteoblast cells assessed as expression ratio of treated to untreated control by microarray analysis | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID719270 | Inhibition of TNFalpha-induced NF-kappaB activity expressed in HEK293 cells at 50 uM by luciferase reporter gene assay | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1). |
| AID1573652 | Activation of Nrf2 in rat HBZY-1 cells assessed as increase in HO-1 mRNA expression at 6 uM after 24 hrs by RT-PCR analysis | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and biological evaluation of bifendate derivatives bearing acrylamide moiety as novel antioxidant agents. |
| AID1168354 | Hepatoprotective activity against isoniazid-rifampicin induced liver injury in BALB/c mouse assessed as reduction AST level at 100 mg/kg, po bid for 3 days starting 30 mins prior isoniazid-rifampicin administration measured 24 hrs post-last dose of isonia | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. |
| AID770334 | Competitive inhibition of human quinone reductase 2 using menadione/N-methyldihydronicotinamide as substrate after 10 mins by double-reciprocal plot analysis | 2013 | Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19 | Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2. |
| AID1884057 | Antibacterial activity against Enterococcus faecalis V583 incubated for 20 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID725751 | Cytotoxicity against human T47D cells at 50 uM by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 23, Issue:3 | Novel Aza-resveratrol analogs: synthesis, characterization and anticancer activity against breast cancer cell lines. |
| AID1362654 | Disaggregation of self-induced amyloid beta (1 to 40) (unknown origin) preformed fibrils assessed as fluorescence emission at 100 uM after 4 days by thioflavin-T based assay (Rvb = 322.95 +/- 17.69 No_unit) | |||
| AID478953 | Antiproliferative activity against human JR8 cells after 72 hrs | 2010 | Bioorganic & medicinal chemistry, May-15, Volume: 18, Issue:10 | Design, synthesis and anticancer activities of stilbene-coumarin hybrid compounds: Identification of novel proapoptotic agents. |
| AID1632225 | Selectivity index, ratio of CD50 against human MHRF cells to CD50 for human T24 cells after 72 hrs | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18 | Synthesis and anticancer activity of a hydroxytolan series. |
| AID692947 | Inhibition of Wnt/beta-casein in human LS174T cells assessed as reduction in CD44 mRNA level at 100 uM after 36 hrs by RT-PCR analysis | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID432161 | Inhibition of FSL1-induced upregulation of DC-SIGN mRNA expression in in human THP1 cells at 100 uM after 1 hr by RT-PCR | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID432167 | Inhibition of phagocytosis of FITC-conjugated Staphylococcus aureus 209P in mouse RAW264.7 cells using trypan blue staining after 40 mins by flow cytometry | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID1306440 | Inhibition of recombinant human CYP1A1 expressed in Escherichia coli DH5aplha cells assessed as O-deethylation of ethoxyresorufin in presence of NADPH at 100 uM measured after 2 mins by spectrofluorometric method | 2016 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 26, Issue:14 | Aryl morpholino triazenes inhibit cytochrome P450 1A1 and 1B1. |
| AID432140 | Inhibition of phagocytosis of FITC-conjugated Escherichia coli K12 in mouse RAW264.7 cells assessed as reduction in ratio of number of bacterial cells to phagocytes using trypan blue staining by flow cytometry | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. |
| AID1220761 | AUC (0 to infinity) in C57BL/6 mouse at 15 mg/kg administered intraarterially by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Oct, Volume: 40, Issue:10 | In vivo-formed versus preformed metabolite kinetics of trans-resveratrol-3-sulfate and trans-resveratrol-3-glucuronide. |
| AID1168362 | Hepatoprotective activity against isoniazid-rifampicin induced liver injury in BALB/c mouse assessed as reduction in IL6 level at 100 mg/kg, po bid for 3 days starting 30 mins prior isoniazid-rifampicin administration measured 24 hrs post-last dose of iso | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. |
| AID1333783 | Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 48 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1 | Synthesis and bioactivity evaluation of 2,3-diaryl acrylonitrile derivatives as potential anticancer agents. |
| AID1573654 | Activation of Nrf2 in rat HBZY-1 cells assessed as increase in GCLC mRNA expression at 6 uM after 24 hrs by RT-PCR analysis | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and biological evaluation of bifendate derivatives bearing acrylamide moiety as novel antioxidant agents. |
| AID1298372 | Selectivity index, ratio of 5-Aza-C CC50 for human U373-MAGI cells to 5-Aza-C EC50 for VSV-G pseudotyped HIV-1 NL4-3 in presence of 50 uM compound (Rvb = 2.8 No_unit) | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID738190 | Inhibition of NFkappaB signaling pathway in human HeLa cells assessed as measured as lowest concentration required 50 to 60 % inhibition of PMA induced luciferase treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID1173641 | Antiproliferative activity against human MDA468 cells by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23 | Synthesis and antiproliferative evaluation of 2-hydroxylated (E)-stilbenes. |
| AID692950 | Inhibition of Wnt/beta-casein in human LS174T cells assessed as effect on beta-casein protein level at 100 uM by Western blotting | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID1674579 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 at 256 ug/ml after 24 hrs by broth microdilution assay | 2020 | Journal of natural products, 08-28, Volume: 83, Issue:8 | Generation of Stilbene Antimicrobials against Multiresistant Strains of |
| AID1062135 | Antibiofilm activity against Escherichia coli O157:H7 assessed as repression of csgF expression at 20 ug/ml after 5 hrs by qRT-PCR analysis | 2014 | Journal of natural products, Jan-24, Volume: 77, Issue:1 | Resveratrol oligomers inhibit biofilm formation of Escherichia coli O157:H7 and Pseudomonas aeruginosa. |
| AID637964 | Antibacterial activity against CagA-expressing Helicobacter pylori G27 isolated from chronic gastritis patient after 48 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID713111 | Drug metabolism assessed as oxidation of the compound at 100 uM after 60 mins by HPLC analysis in the presence of tyrosinase | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID724573 | Binding affinity to curcumin encapsulated liposomes assessed as curcumin release from unilamellar vesicles at 100 uM after 20 mins NMR spectroscopic analysis | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Dose-dependent interaction of trans-resveratrol with biomembranes: effects on antioxidant property. |
| AID1298374 | Potentiation of 5-Aza-dC-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as reduction in viral infectivity at 25 uM preincubated for 2 hrs followed by 5-Aza-dC addition for 2 hrs and subsequent v | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID359086 | Increase in osteopontin mRNA levels in human MG63 cells at 1 uM after 72 hrs by RT-PCR | 2007 | The Journal of biological chemistry, Jul-06, Volume: 282, Issue:27 | Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. |
| AID1730040 | Neuroprotective activity against amyloid beta 42-induced toxicity in rat primary cortical neurons at 10 uM | |||
| AID1882449 | Inhibition of human HDAC4 at 100 uM relative to control | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4 | Chasing a Breath of Fresh Air in Cystic Fibrosis (CF): Therapeutic Potential of Selective HDAC6 Inhibitors to Tackle Multiple Pathways in CF Pathophysiology. |
| AID1311774 | Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as iNOS levels at 50 umol/L by ELISA (Rvb = 31.63 +/- 3.26 U/mL) | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata. |
| AID1317149 | Oral bioavailability in human at 50 uCi up to 12 hrs using 14C-labeled compound by scintillation counting method | 2016 | European journal of medicinal chemistry, Aug-25, Volume: 119 | How much successful are the medicinal chemists in modulation of SIRT1: A critical review. |
| AID418720 | Inhibition of human quinone reductase 2 expressed in Escherichia coli BL21(DE3) incubated at 23 degC by MTT assay | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7 | Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. |
| AID1608139 | Cytoprotection activity against H2O2-induced cell death in rat HBZY-1 cells assessed as cell viability at 6 uM preincubated with compound for 2 hrs followed by H2O2 addition and measured after 24 hrs by MTT assay (Rvb = 62.1%) | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Synthesis and assessment of phenylacrylamide derivatives as potential anti-oxidant and anti-inflammatory agents. |
| AID1298319 | Effect on 5-aza-dCTP level in human U373-MAGI cells at 200 uM preincubated for 2 hrs followed by 5-aza-dC addition measured after 4 hrs by LC-MS/MS analysis | 2016 | Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11 | Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. |
| AID589205 | Mechanism based inhibition of human cytochrome P450 1A1 measured by 7-ethoxyresorufin O-deethylation (EROD) | 2005 | Current drug metabolism, Oct, Volume: 6, Issue:5 | Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. |
| AID637961 | Antibacterial activity against CagA-expressing Helicobacter pylori MDO21 isolated from chronic gastritis patient after 48 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1188905 | Induction of SV40 promoter-mediated luciferase gene expression in human HeLa cells at 10 to 100 uM after 24 hrs by RT-PCR analysis | 2014 | ACS medicinal chemistry letters, Aug-14, Volume: 5, Issue:8 | Total Synthesis and Biological Studies of TMC-205 and Analogues as Anticancer Agents and Activators of SV40 Promoter. |
| AID455037 | Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay | 2009 | Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18 | E-Combretastatin and E-resveratrol structural modifications: antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes. |
| AID638048 | Antibacterial activity against CagA-expressing Helicobacter pylori SI10 isolated from chronic gastritis patient after 48 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1879018 | Antifibrotic activity in CCL-4 induced liver fibrosis C57/B6J mouse model assessed as reduction in hydroxyproline level in liver at 100 mg/kg/day, ip measured after 72 hrs post last dose | 2022 | Bioorganic & medicinal chemistry, 03-01, Volume: 57 | Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis. |
| AID639328 | Antibacterial activity against CagA-expressing Helicobacter pylori 18K7 isolated from gastric carcinoma patient after 24 hrs compound exposure followed by incubation on Columbia-blood agar plate for 3 to 5 days | 2011 | Journal of natural products, Oct-28, Volume: 74, Issue:10 | Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. |
| AID1225528 | Reduction in PARP1 expression in prostate tissue in BPH-induced Sprague-Dawley rat model at 1 mg/kg, ip daily for 4 weeks by Western blot analysis | 2015 | Journal of natural products, Apr-24, Volume: 78, Issue:4 | Effects of resveratrol on benign prostatic hyperplasia by the regulation of inflammatory and apoptotic proteins. |
| AID1884063 | Antibacterial activity against Clostridium beijerinckii B504 incubated for 24 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID713110 | Inhibition of mushroom tyrosinase-mediated dopachrome formation after 60 mins by UV-vis spectrophotometric analysis | 2012 | Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2 | Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor. |
| AID692974 | Inhibition of Wnt/beta-casein in human LS 174T cells assessed as reduction in TCF4 protein level at 100 uM by Western blotting | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID749797 | Inhibition of VEGF mRNA expression in human HT-29 cells at 20 ug/mL after 48 hrs by RT-PCR analysis relative to control | 2013 | Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11 | Inhibition of VEGF expression in cancer cells and endothelial cell differentiation by synthetic stilbene derivatives. |
| AID1420922 | Antibacterial activity against Vibrio cholerae after 17 hrs by NCCLS broth microdilution method | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Antibacterial and antioxidant activities for natural and synthetic dual-active compounds. |
| AID1430670 | Cytotoxicity against human MIAPaCa2 cells assessed as growth inhibition at 30 uM after 72 hrs by CellTitre-Glo luminescent assay relative to control | 2017 | ACS medicinal chemistry letters, May-11, Volume: 8, Issue:5 | Toward Resolving the Resveratrol Conundrum: Synthesis and |
| AID642342 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at 40 uM preincubated for 30 mins before LPS challenge measured after 24 hrs by Griess method | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4 | A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347045 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot counterscreen GloSensor control cell line | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500 | Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID588378 | qHTS for Inhibitors of ATXN expression: Validation | |||
| AID1347057 | CD47-SIRPalpha protein protein interaction - LANCE assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7 | Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID588349 | qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay | |||
| AID1347410 | qHTS for inhibitors of adenylyl cyclases using a fission yeast platform: a pilot screen against the NCATS LOPAC library | 2019 | Cellular signalling, 08, Volume: 60 | A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening. |
| AID504836 | Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in human glioma: Validation | 2002 | The Journal of biological chemistry, Apr-19, Volume: 277, Issue:16 | Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. |
| AID1347405 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS LOPAC collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347058 | CD47-SIRPalpha protein protein interaction - HTRF assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7 | Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347049 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot screen | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500 | Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347151 | Optimization of GU AMC qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347050 | Natriuretic polypeptide receptor (hNpr2) antagonism - Pilot subtype selectivity assay | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500 | Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347095 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347105 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347424 | RapidFire Mass Spectrometry qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1) | 2019 | The Journal of biological chemistry, 11-15, Volume: 294, Issue:46 | Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347090 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347103 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347092 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347094 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347089 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347107 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347098 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347091 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347100 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347425 | Rhodamine-PBP qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1) | 2019 | The Journal of biological chemistry, 11-15, Volume: 294, Issue:46 | Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. |
| AID1347407 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Pharmaceutical Collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347097 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347108 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347101 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347099 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347096 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347106 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347104 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347093 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347102 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1801525 | Tyrosinase Activity from Article 10.1016/j.bioorg.2016.01.001: \\Synthesis and tyrosinase inhibition activity of trans-stilbene derivatives.\\ | 2016 | Bioorganic chemistry, Feb, Volume: 64 | Synthesis and tyrosinase inhibition activity of trans-stilbene derivatives. |
| AID1799522 | EROD Assay from Article 10.1016/j.chembiol.2007.05.004: \\Synthesis of unnatural flavonoids and stilbenes by exploiting the plant biosynthetic pathway in Escherichia coli.\\ | 2007 | Chemistry & biology, Jun, Volume: 14, Issue:6 | Synthesis of unnatural flavonoids and stilbenes by exploiting the plant biosynthetic pathway in Escherichia coli. |
| AID1799023 | QR2 Inhibition Assay from Article 10.1042/BJ20071373: \\Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2.\\ | 2008 | The Biochemical journal, Jul-01, Volume: 413, Issue:1 | Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2. |
| AID1798379 | In Vitro Binding Assay from Article 10.1021/jm0498194: \\Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators.\\ | 2005 | Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1 | Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. |
| AID1799638 | Inhibition Assay from Article 10.1002/cbic.201000376: \\A novel competitive class of u00CEu00B1-glucosidase inhibitors: (E)-1-phenyl-3-(4-styrylphenyl)urea derivatives.\\ | 2010 | Chembiochem : a European journal of chemical biology, Oct-18, Volume: 11, Issue:15 | A novel competitive class of α-glucosidase inhibitors: (E)-1-phenyl-3-(4-styrylphenyl)urea derivatives. |
| AID1798975 | QR2 Assay and IC50 Value Determination from Article 10.1021/jm801335z: \\Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities.\\ | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7 | Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. |
| AID1224864 | HCS microscopy assay (F508del-CFTR) | 2016 | PloS one, , Volume: 11, Issue:10 | Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6 | A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | |||
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2011 | Biochemistry, Mar-01, Volume: 50, Issue:8 | Structure of trans-resveratrol in complex with the cardiac regulatory protein troponin C. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2014 | Chembiochem : a European journal of chemical biology, May-26, Volume: 15, Issue:8 | Resveratrol and its metabolites bind to PPARs. |
| AID1159550 | Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening | 2015 | Nature cell biology, Nov, Volume: 17, Issue:11 | 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. |
| AID1745855 | NCATS anti-infectives library activity on the primary C. elegans qHTS viability assay | 2023 | Disease models & mechanisms, 03-01, Volume: 16, Issue:3 | In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. |
| AID1745854 | NCATS anti-infectives library activity on HEK293 viability as a counter-qHTS vs the C. elegans viability qHTS | 2023 | Disease models & mechanisms, 03-01, Volume: 16, Issue:3 | In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. |
| AID977608 | Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15 | Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2015 | Biochimica et biophysica acta, Apr, Volume: 1854, Issue:4 | Structures and binding studies of the complexes of phospholipase A2 with five inhibitors. |
| AID657370 | Inhibition of cytosolic human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins. |
| AID657380 | Inhibition of human carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins. |
| AID657381 | Inhibition of human carbonic anhydrase 13 preincubated for 15 mins by stopped flow CO2 hydration assay | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins. |
| AID657382 | Inhibition of human carbonic anhydrase 14 preincubated for 15 mins by stopped flow CO2 hydration assay | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins. |
| AID657378 | Inhibition of human carbonic anhydrase 5b preincubated for 15 mins by stopped flow CO2 hydration assay | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins. |
| AID657383 | Inhibition of mouse carbonic anhydrase 15 preincubated for 15 mins by stopped flow CO2 hydration assay | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins. |
| AID657377 | Inhibition of human carbonic anhydrase 4 preincubated for 15 mins by stopped flow CO2 hydration assay | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins. |
| AID657384 | Inhibition of human carbonic anhydrase 5a preincubated for 15 mins by stopped flow CO2 hydration assay | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins. |
| AID657376 | Inhibition of human carbonic anhydrase 3 preincubated for 15 mins by stopped flow CO2 hydration assay | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins. |
| AID657374 | Inhibition of transmembrane tumor-associated human carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins. |
| AID657368 | Inhibition of cytosolic human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins. |
| AID657372 | Inhibition of transmembrane tumor-associated human carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins. |
| AID657379 | Inhibition of human carbonic anhydrase 6 preincubated for 15 mins by stopped flow CO2 hydration assay | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347091 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347105 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347099 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347100 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347102 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347094 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347089 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347093 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347106 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347095 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347096 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4 | A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347090 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID1347092 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347107 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347108 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347097 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347098 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347101 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347104 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347103 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (0.01) | 18.7374 |
| 1990's | 129 (1.21) | 18.2507 |
| 2000's | 2091 (19.57) | 29.6817 |
| 2010's | 6140 (57.46) | 24.3611 |
| 2020's | 2324 (21.75) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (71.08) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 241 (2.20%) | 5.53% |
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1,361 (12.45%) | 6.00% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 11 (0.10%) | 4.05% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 8 (0.07%) | 0.25% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 9,310 (85.17%) | 84.16% |
| Other | 8 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Enhancing Memory Functions in Patients With Mild Cognitive Impairment by Dietary Interventions and in Combination With Exercise and Cognitive Training - Proof of Concept and Mechanisms [NCT01219244] | Phase 2/Phase 3 | 330 participants (Anticipated) | Interventional | 2010-08-31 | Completed | ||
| Safety and Efficacy of an Antioxidant Based Dietary Supplement With PUFAs in Healthy Female Volunteers With Cellulite (Orange Peel Skin) [NCT01321268] | 8 participants (Actual) | Interventional | 2011-05-31 | Terminated(stopped due to sponsor stopped study due to recruitment problems) | |||
| Resveratrol and Exercise to Treat Functional Limitations in Late Life [NCT02523274] | Phase 2 | 60 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| A Pilot RCT on the Effect of Resveratrol on Mood, Memory Deficits, Hippocampal Inflammation and Neurogenesis in Veterans With Gulf War Illness [NCT03665740] | Phase 2 | 68 participants (Anticipated) | Interventional | 2018-08-01 | Recruiting | ||
| Efficacy and Safety of a New Medical Device Based on Resveratrol and Carbossimetyl Beta Glucan in Treatment of Upper Airways Disease in Infancy [NCT03683108] | Phase 3 | 100 participants (Actual) | Interventional | 2015-12-31 | Completed | ||
| Evaluating the Clinical Efficacy of Resveratrol in Improving Metabolic and Skeletal Muscle Function in Patients With Heart Failure [NCT03525379] | Phase 2 | 13 participants (Actual) | Interventional | 2017-10-26 | Completed | ||
| Resveratrol Supplementation in Patients With Mitochondrial Myopathies and Skeletal Muscle Fatty Acid Oxidation Disorders: A Double-blind, Placebo-controlled, Cross Over Study [NCT03728777] | 20 participants (Actual) | Interventional | 2018-04-09 | Completed | |||
| Pilot Study of Resveratrol in Postmenopausal Women With High Body Mass Index [NCT01370889] | Phase 1 | 46 participants (Actual) | Interventional | 2011-06-30 | Completed | ||
| The Effects of Resveratrol on Serum Apolipoprotein A-I Concentrations in Men and Women With Low HDL-cholesterol Concentrations [NCT01364961] | 50 participants (Actual) | Interventional | 2011-01-31 | Completed | |||
| Effects of Reveratrol on Cardiovascular Risk Markers and Cognitive Performance in Patients With Schizophrenia: a Randomized Clinical Trilal [NCT02062190] | Phase 2 | 19 participants (Actual) | Interventional | 2014-03-31 | Completed | ||
| Evaluation of the Beneficial Effects of a Nasal Spray of Resveratrol in Children With Seasonal Allergic Rhinitis [NCT02130440] | Phase 3 | 100 participants (Actual) | Interventional | 2012-11-30 | Completed | ||
| The Effect of Resveratrol on Metabolism and Cardiovascular Risk Profile in Patients With Chronic Obstructive Pulmonary Disease (COPD) [NCT02245932] | 23 participants (Actual) | Interventional | 2015-01-31 | Completed | |||
| The Curative Effect and Security of Interferon Combined Resveratrol on HBeAg Positive Chronic Hepatitis B Patients - a Multi-center, Random, Control, Open Clinical Trial. [NCT03546530] | 228 participants (Actual) | Interventional | 2016-06-01 | Completed | |||
| Resveratrol and Midazolam Metabolism [NCT01173640] | 6 participants (Actual) | Interventional | 2010-07-31 | Completed | |||
| Pilot Study Of The Effects Of Resveratrol On Endothelial Function In Subjects With Type 2 Diabetes Mellitus [NCT01038089] | 20 participants (Anticipated) | Interventional | 2010-01-31 | Completed | |||
| A Phase 1 Study to Assess the Pharmacokinetics and Safety of Ascending Doses of JOTROL Oral Gelcaps in Healthy Subjects, and to Determine the Influence of Food [NCT04668274] | Phase 1 | 24 participants (Actual) | Interventional | 2021-01-21 | Completed | ||
| Resveratrol as a Preventive Treatment of Ovarian Hyperstimulation Syndrome [NCT03446625] | Phase 3 | 70 participants (Actual) | Interventional | 2018-03-13 | Completed | ||
| Investigation of the Effects of Curcumin and Resveratrol Supplements Added to the Mediterranean Diet on Disease Severity and Inflammatory Biomarkers in Patients With Ulcerative Colitis [NCT05761327] | 45 participants (Anticipated) | Interventional | 2022-06-03 | Recruiting | |||
| An Open-Label, Randomized, Double Arm, Phase 2 Study to Evaluate the Safety and Efficacy of C and RQC for Preventing Progression in Age-Related Macular Degeneration [NCT05062486] | Phase 2 | 150 participants (Anticipated) | Interventional | 2021-07-22 | Recruiting | ||
| Therapeutic Metabolic Intervention in Patients With Spastic Paraplegia SPG5 [NCT02314208] | Phase 2 | 12 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| A Double-blind, Randomised, Placebo-controlled, Rising Multiple Dose Study in Healthy Volunteers to Investigate the Effect of BIA 6-512 at Steady-state on the Levodopa Pharmacokinetics When Administered in Combination With a Single-dose of Levodopa/Benser [NCT03094156] | Phase 1 | 39 participants (Actual) | Interventional | 2006-04-26 | Completed | ||
| Effects of Combined Resveratrol and Myo-inositol on Altered Metabolic, Endocrine Parameters and Perceived Stress in Patients With Polycystic Ovarian Syndrome [NCT04867252] | Phase 2 | 88 participants (Actual) | Interventional | 2021-05-03 | Completed | ||
| Resveratrol and Human Hepatocyte Function in Cancer [NCT02261844] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2015-12-31 | Withdrawn(stopped due to No funding) | ||
| The Acute and Chronic Effects of Resveratrol Supplementation on Cognitive Function, Gastrointestinal Microbiota and Cerebral Blood Flow: a Double-blind, Placebo-controlled, Parallel-groups Study in Healthy, Overweight Humans. [NCT03448094] | 110 participants (Actual) | Interventional | 2018-02-06 | Completed | |||
| Effects of Resveratrol on Insulin Sensitivity, Brown Adipose Tissue and Metabolic Profile in First-degree Relatives of Type 2 Diabetic Patients [NCT02129595] | 15 participants (Actual) | Interventional | 2014-04-30 | Completed | |||
| The Impact of Acute Trans-resveratrol Administration on Whole Body Metabolism During Cognitive Task Performance: a Double Blind, Randomised, Placebo-controlled Investigation. [NCT03546075] | 27 participants (Actual) | Interventional | 2015-05-07 | Completed | |||
| Effects of Resveratrol Supplements on Vascular Health in Postmenopausal Women [NCT01564381] | Phase 1/Phase 2 | 64 participants (Actual) | Interventional | 2012-03-31 | Completed | ||
| The Curative Effect and Security of Entecavir Combined Thymosin or Resveratrol on HBeAg Positive Chronic Hepatitis B Patients - a Multi-center, Random, Control, Open Clinical Trial [NCT03509688] | 312 participants (Actual) | Interventional | 2014-11-30 | Completed | |||
| Biological Effects in Consumers of Resveratrol-enriched Wine [NCT05981053] | 30 participants (Actual) | Observational | 2022-07-15 | Completed | |||
| Pharmacokinetics of Trans-resveratrol Based Nutritional Supplement and Its Three Metabolites in Human Eyes and Blood [NCT02321176] | 20 participants (Anticipated) | Interventional | 2014-03-31 | Recruiting | |||
| GRAPe Seed Extract and Ventriculovascular Investigation in Normal Ejection-Fraction Heart Failure [NCT01185067] | Phase 1 | 15 participants (Actual) | Interventional | 2010-10-31 | Completed | ||
| A Pilot Study of Resveratrol Supplementation for Memory and Physical Performance [NCT01126229] | Phase 1 | 32 participants (Actual) | Interventional | 2009-11-30 | Completed | ||
| Potential Beneficial Effects of Resveratrol on Obesity, Metabolic Syndrome and Inflammation - Emphasis on Description of the Molecular Biology Underpinning the Interplay Between Calorie Restriction, SIRT1, STAT5 and the GH/IGF-I Axis [NCT01150955] | 24 participants (Actual) | Interventional | 2010-10-31 | Completed | |||
| Effects of Resveratrol Alone or in Combination With Piperine on Cerebral Blood Flow Parameters and Cognitive Performance in Humans [NCT01331382] | 23 participants (Actual) | Interventional | 2010-04-30 | Completed | |||
| An Open Label Clinical Pilot Study of Resveratrol as Treatment for Friedreich Ataxia [NCT01339884] | Phase 1/Phase 2 | 27 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| A Phase 1, Double-Blind, Randomized Clinical Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of SRT501 in Subjects With Colorectal Cancer and Hepatic Metastases [NCT00920803] | Phase 1 | 9 participants (Actual) | Interventional | 2008-08-19 | Completed | ||
| Resveratrol and Cardiovascular Health in the Elderly: The Reache Trial [NCT01842399] | Phase 1/Phase 2 | 73 participants (Actual) | Interventional | 2015-07-14 | Terminated(stopped due to The protocol experienced slow accrual.) | ||
| Effects of Long-term Resveratrol Supplementation on Metabolic Health [NCT02565979] | 42 participants (Actual) | Interventional | 2016-04-30 | Completed | |||
| Randomized, Placebo-controlled Clinical Trial of Resveratrol Supplement Effects on Cognition, Function and Behavior in Patients With Mild-to-moderate Alzheimer's Disease [NCT00743743] | Phase 3 | 0 participants (Actual) | Interventional | 2008-09-30 | Withdrawn(stopped due to PI has left institution) | ||
| Resveratrol: A Potential Anti- Remodeling Agent in Heart Failure, From Bench to Bedside (RES-HF) [NCT01914081] | Phase 3 | 40 participants (Anticipated) | Interventional | 2018-10-09 | Recruiting | ||
| Effect of Resvida(tm) Dietary Supplementation on Muscle Gene Expression: A Comparison With Calorie Restriction Regimen [NCT00823381] | 58 participants (Actual) | Interventional | 2009-01-31 | Completed | |||
| The proBNPage Reduction (PBAR) Randomized Trial: a Pilot Study to Define the Characteristics of Future Randomized Trials Aimed at Evaluating the Effects of Anti-aging Treatments on a Surrogate of Biological Age in Healthy Older Adults [NCT05500742] | 120 participants (Actual) | Interventional | 2022-07-22 | Active, not recruiting | |||
| Long-term Supplementation of Dietary Polyphenols as Modulators of Lipid Oxidation and Mitochondrial Function in Overweight Volunteers [NCT02381145] | 42 participants (Actual) | Interventional | 2012-08-31 | Completed | |||
| Mechanisms in IGF2 Induced Chemoresistance and Mitochondrial Regulation in Triple Negative Breast Cancer [NCT04266353] | 0 participants (Actual) | Interventional | 2019-04-24 | Withdrawn(stopped due to Due to COVID-19) | |||
| The Effect of Resveratrol in Older Adults With Impaired Glucose Tolerance: a Double-Blind Crossover Study [NCT01375959] | 38 participants (Actual) | Interventional | 2011-04-30 | Completed | |||
| A Randomized, Investigator Blinded, Single Site, Three Arm Clinical Study to Assess the Functional and Emotional Benefits of Replenix Power of Three Cream With Resveratrol , Replenix Power of Three Cream With Resveratrol With Adapalene and Benzoyl Peroxid [NCT03563365] | Phase 4 | 43 participants (Actual) | Interventional | 2018-06-04 | Terminated(stopped due to Lack of Funding) | ||
| Assessment of Resveratrol, Alpha Lipoic Acid and Superoxide Dismutase on Oxidative Stress Biomarkers in Type 2 Diabetes Mellitus Patients With Neuropathy: A Randomized Control Trial [NCT06131918] | Phase 2 | 100 participants (Actual) | Interventional | 2023-01-09 | Active, not recruiting | ||
| The Cerebral Hemodynamic and Cognitive Effects of Acute Resveratrol Administration in Young, Healthy Adults at 4000 m Stimulated Altitude and at Sea Level: A Double Blind, Crossover Investigation. [NCT03541993] | 24 participants (Actual) | Interventional | 2016-06-07 | Completed | |||
| Effects of Resveratrol on Crosstalk Between Canonical β-catenin/Wnt and FOXO Pathways in Coronary Artery Disease Patients With Metabolic Syndrome: A Case Control Study [NCT02137421] | 20 participants (Actual) | Interventional | 2012-04-30 | Completed | |||
| Cardiovascular Risk and Benefits From Antioxidant Dietary Intervention With Red Wine in Asymptomatic Hypercholesterolemics [NCT02409537] | Phase 2 | 37 participants (Actual) | Interventional | 2013-03-31 | Completed | ||
| The Effects of Resveratrol Supplement on Lipid Profile, Liver Enzymes, Inflammatory Factors and Hepatic Fibrosis in Patients With Nonalcoholic Steatohepatitis [NCT02030977] | Phase 2/Phase 3 | 50 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
| Clinical Study of Resveratrol on Drug and Carcinogen Metabolizing Enzymes [NCT00721877] | Phase 1 | 42 participants (Actual) | Interventional | 2008-08-31 | Completed | ||
| Nicotinamide Riboside With and Without Resveratrol to Improve Functioning in Peripheral Artery Disease: The NICE Trial [NCT03743636] | Phase 3 | 90 participants (Actual) | Interventional | 2018-10-01 | Completed | ||
| Effect of resVida on Fat Oxidation and Mitochondrial Biogenesis in Healthy Obese Subjects [NCT00998504] | 18 participants (Anticipated) | Interventional | 2009-10-31 | Completed | |||
| Resveratrol's Effects in Diabetic Nephropathy [NCT02704494] | Early Phase 1 | 60 participants (Actual) | Interventional | 2016-03-31 | Completed | ||
| Acute Influence of Resveratrol Supplementation and Beet Extract in Recovery After Exercise Submaximal Aerobic in Coronary Paths: a Study Prospective, Randomized Placebo-controlled [NCT06095635] | 17 participants (Actual) | Interventional | 2022-03-10 | Completed | |||
| Prospective, Randomized, Double - Blind Placebo Controlled Trial of Simvastatin and Resveratrol Therapy on Clinical, Endocrinological, Biochemical and Endothelial Dysfunction Parameters in Women With Polycystic Ovary Syndrome. [NCT02766803] | Phase 4 | 60 participants (Anticipated) | Interventional | 2016-05-31 | Recruiting | ||
| A Randomized, Double-Blind Pilot Trial of Resveratrol With or Without Piperine to Enhance Plasma Levels of Resveratrol [NCT01324089] | 24 participants (Actual) | Interventional | 2011-03-31 | Completed | |||
| Pilot Study to Test the Safety and Efficacy of Metformin, Dasatinib, Rapamycin and Nutritional Supplements (Bio-quercetin; Bio-fisetin; Glucosamine; Nicotinamide Riboside; Trans-resveratrol) in Reducing Clinical Measures of Aging in Older Adults [NCT04994561] | Phase 1 | 0 participants (Actual) | Interventional | 2022-06-30 | Withdrawn(stopped due to Study was withdrawn) | ||
| A Single Center, Multi-site, Randomized, Double-blind, Placebo-controlled Trial of Resveratrol With Glucose and Malate (RGM) to Slow the Progression of Alzheimer's Disease [NCT00678431] | Phase 3 | 27 participants (Actual) | Interventional | 2008-01-31 | Completed | ||
| Mechanisms of Metabolic Regulation of Resveratrol on Humans With Metabolic Syndrome. [NCT00654667] | Phase 2 | 0 participants (Actual) | Interventional | 2007-05-31 | Withdrawn(stopped due to no participant enrollment) | ||
| The Acute and Chronic Effects of Resveratrol Supplementation on Inflammation and Cognitive Performance in Healthy Adults [NCT04314739] | 100 participants (Actual) | Interventional | 2019-03-19 | Completed | |||
| Impact of Resveratrol and Pharmaceutical Care on Diabetes Mellitus and Its Neuropathic Complication [NCT05172947] | 120 participants (Actual) | Interventional | 2021-12-05 | Completed | |||
| Effect of Resveratrol on Age-related Insulin Resistance and Inflammation in Humans [NCT01354977] | Phase 2 | 20 participants (Actual) | Interventional | 2008-03-31 | Completed | ||
| Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1 [NCT04449198] | Early Phase 1 | 24 participants (Anticipated) | Interventional | 2020-10-14 | Recruiting | ||
| Non-pulmonary Contributors of Exercise Intolerance in Patients With Cystic Fibrosis [NCT04166396] | 36 participants (Anticipated) | Interventional | 2020-02-17 | Recruiting | |||
| Effect of 6 Weeks Resveratrol Supplementation on Vascular Function in CKD [NCT03597568] | 25 participants (Anticipated) | Interventional | 2019-01-01 | Active, not recruiting | |||
| Long-term Investigation of Resveratrol on Management of Metabolic Syndrome, Osteoporosis and Inflammation, and Identification of Plant Derived Anti-inflammatory Compounds [NCT01412645] | 76 participants (Actual) | Interventional | 2011-08-31 | Completed | |||
| Influence of Resveratrol and Resvega Versus Placebo on Incidence of Bilateralisation of Exudative AMD: a Double Masked Prospective Study. [NCT02625376] | 25 participants (Actual) | Interventional | 2015-08-06 | Terminated | |||
| Evaluating the Efficacy of Resveratrol Containing Mouthwash as Adjunct Treatment for Periodontitis: [NCT05874882] | Early Phase 1 | 40 participants (Anticipated) | Interventional | 2022-12-12 | Recruiting | ||
| Short Interval Resveratrol Trial in Cardiovascular Surgery [NCT03762096] | 40 participants (Anticipated) | Interventional | 2018-03-06 | Active, not recruiting | |||
| Randomized Crossover Study of The Effects of Resveratrol on Endothelial Function in Subjects With Type 2 Diabetes Mellitus [NCT01881347] | 54 participants (Actual) | Interventional | 2013-01-01 | Completed | |||
| Clinical Efficacy Analysis of Resveratrol in the Treatment of Primary Ovarian Insufficiency [NCT05410093] | 150 participants (Anticipated) | Interventional | 2022-02-01 | Recruiting | |||
| The Effect of Resveratrol and Curcumin on Postprandial Inflammation in Men and Postmenopausal Women [NCT01964846] | 22 participants (Actual) | Interventional | 2013-10-31 | Completed | |||
| Can Resveratrol Improve Insulin Sensitivity and Preserve Beta Cell Function Following Gestational Diabetes? [NCT01997762] | Phase 4 | 112 participants (Anticipated) | Interventional | 2014-05-31 | Recruiting | ||
| Safety and Efficacy of Resveratrol for the Treatment of Non-Alcoholic Fatty Liver Disease and Associated Insulin Resistance in Overweight and Obese Adolescents [NCT02216552] | Phase 2/Phase 3 | 10 participants (Actual) | Interventional | 2015-08-31 | Completed | ||
| Resveratrol in Metabolic Syndrome: Effect on Platelet Hyper-reactivity and HDL Lipid Peroxidation [NCT02219906] | 41 participants (Actual) | Interventional | 2014-05-31 | Completed | |||
| Effect of Administration of Resveratrol on Glycemic Variability in Individuals With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin [NCT02549924] | Phase 2 | 22 participants (Actual) | Interventional | 2016-09-30 | Terminated(stopped due to no financial support) | ||
| Acute Effects Of Trans-Resveratrol in Endothelial Function in Treated Hypertensive Patients [NCT02616822] | Phase 1 | 24 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| Phase IV Interventional Study: Effects of Dietary Interventions on Brain Functions in Healthy Elderly People [NCT00996229] | Phase 3 | 300 participants (Anticipated) | Interventional | 2009-11-30 | Recruiting | ||
| Randomized, Single-blind, Cross-over Pilot Study to Evaluate the Plasma Profile of Resveratrol Following an Oral Administration of Either Revifast® (Resveratrol From Polygonum Cuspidatum Extract Siebold & Zucc - Root Supported on Magnesium Hydration With [NCT04258306] | 6 participants (Actual) | Interventional | 2017-10-01 | Completed | |||
| Resveratrol Trial for Relief of Pain in Pseudoachondroplasia [NCT03866200] | Phase 2 | 6 participants (Actual) | Interventional | 2019-06-29 | Terminated(stopped due to Inability to recruit target number) | ||
| The Effects of Resveratrol on Inhibitors of Apoptosis Proteins, on Soluble Receptors of Advanced Glycation End Products and on Sirtuins-1 and -3 in Postmenopausal Women With Coronary Artery Disease [NCT05808387] | 80 participants (Anticipated) | Interventional | 2023-03-06 | Recruiting | |||
| Curcumin, Resveratrol, and Stinging Nettle as Treatments for Gulf War Illness [NCT05377242] | 300 participants (Anticipated) | Interventional | 2023-05-31 | Recruiting | |||
| A Randomised Placebo-controlled Crossover Trial of Micronised Resveratrol as a Treatment for Friedreich Ataxia [NCT03933163] | Phase 2 | 25 participants (Actual) | Interventional | 2019-05-23 | Active, not recruiting | ||
| BDPP Treatment for Mild Cognitive Impairment (MCI) and Prediabetes or Type 2 Diabetes Mellitus (T2DM) [NCT02502253] | Phase 1 | 14 participants (Actual) | Interventional | 2015-06-30 | Completed | ||
| Impact of Resveratrol on Brain Function and Structure [NCT02621554] | 60 participants (Actual) | Interventional | 2016-04-30 | Completed | |||
| Estrogen-Mediated Impairments of Vascular Health in Diabetes [NCT03436992] | 198 participants (Anticipated) | Interventional | 2018-04-17 | Recruiting | |||
| Effects of Resveratrol on Inflammation in Type 2 Diabetic Patients. A Double-blind Randomized Controlled Trial [NCT02244879] | Phase 3 | 192 participants (Actual) | Interventional | 2013-10-31 | Completed | ||
| A Biological Study of Resveratrol's Effects on Notch-1 Signaling in Subjects With Low Grade Gastrointestinal Tumors [NCT01476592] | 7 participants (Actual) | Interventional | 2011-12-31 | Completed | |||
| Double-blind Cross-over Randomised Controlled Trial on the Anti-inflammatory and Antioxidant Effects of Resveratrol on Healthy Adults. [NCT01492114] | Phase 3 | 40 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| The Effects of Resveratrol Supplementation on Measurements of Health and Human Performance [NCT01244360] | 44 participants (Actual) | Interventional | 2010-11-30 | Active, not recruiting | |||
| Oral Resveratrol Before ERCP Redused Overall Pancreatitis in Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP): A Multi-center, Single-blinded, Randomized Controlled Trial [NCT02947932] | Phase 4 | 2,700 participants (Anticipated) | Interventional | 2016-12-31 | Not yet recruiting | ||
| Mechanisms for Vascular Dysfunction and Exercise Tolerance in CF [NCT02690064] | 13 participants (Actual) | Interventional | 2015-04-30 | Active, not recruiting | |||
| Long-term Investigation of Resveratrol on Lipid Turnover in Obese Men With Nonalcoholic Fatty Liver Disease. Effects on Liver Fat Content and Basal and Insulin Stimulated FFA and VLDL-triglyceride Metabolism [NCT01446276] | 26 participants (Actual) | Interventional | 2011-11-30 | Completed | |||
| Phase I Repeat-Dose Study of Resveratrol in Colorectal Cancer Patients: Tolerability, Target Tissue Levels and Pharmacodynamics [NCT00433576] | Phase 1 | 20 participants (Actual) | Interventional | 2006-12-31 | Completed | ||
| Phase I Single-Dose Safety and Phamacokinetics Clinical Study of Resveratrol AKA IRB 2003-424 [NCT00098969] | Phase 1 | 40 participants (Anticipated) | Interventional | 2004-09-30 | Completed | ||
| Dietary Intervention in Stage III/IV Follicular Lymphoma. Impact on Markers of Cell Proliferation, Apoptosis, Host Immune Cell Infiltrate and Oxidative Stress. [NCT00455416] | Phase 2 | 45 participants (Anticipated) | Interventional | 2007-04-30 | Recruiting | ||
| Phase II Study to Evaluate the Impact on Biomarkers of Resveratrol Treatment in Patients With Mild to Moderate Alzheimer's Disease [NCT01504854] | Phase 2 | 119 participants (Actual) | Interventional | 2012-05-31 | Completed | ||
| Intermittent Treatment With Nasal Resveratrol and Reduction of Wheezing Episodes in Non Atopic Preschool Children [NCT04689412] | 50 participants (Actual) | Observational | 2018-04-01 | Completed | |||
| Evolution of Pain at Three Months by Oral Resveratrol in Primary Knee Osteoarthritis: a Multicenter, Double-blind, Randomized, Placebo-controlled Trial [NCT02905799] | Phase 3 | 142 participants (Actual) | Interventional | 2017-11-09 | Completed | ||
| Improving Cardiovascular Health in Patients With Chronic Obstructive Pulmonary Disease: a Mechanistic Approach [NCT03819517] | 26 participants (Actual) | Interventional | 2019-07-01 | Completed | |||
| Long-term Investigation of Resveratrol on Management of Metabolic Syndrome, Osteoporosis and Inflammation, and Identification of Plant Derived Anti-inflammatory Compounds, Study 3 [NCT01464801] | 28 participants (Actual) | Interventional | 2011-09-30 | Completed | |||
| A Pilot Randomized Controlled Clinical Study of Resveratrol for Discharged COVID 19 Patients in Order to Evaluate Its Therapeutic Effects Against Fibrosis [NCT04799743] | 30 participants (Anticipated) | Interventional | 2021-04-01 | Recruiting | |||
| Effects of Treatment With Resveratrol on Oocyte and Embryo Quality in Patients Undergoing Assisted Reproductive Techniques( ART) [NCT04386499] | 100 participants (Actual) | Interventional | 2019-01-10 | Completed | |||
| Evaluation of the Metabolic Profile and Autonomic and Cardiovascular Recovery in Response to the Acute Use of Resveratrol in Individuals With Overweight and Obesity [NCT06020313] | 30 participants (Anticipated) | Interventional | 2023-08-31 | Recruiting | |||
| Short-term Investigation of Resveratrol on Lipid Turnover in Morbidly Obese Women Undergoing Gastric Bypass Surgery. Effects on Basal and Insulin Stimulated FFA and VLDL-triglyceride Metabolism and Liver VLDL-triglyceride Uptake. [NCT01826279] | 16 participants (Anticipated) | Interventional | 2013-05-31 | Active, not recruiting | |||
| Resveratrol for Patients With Colon Cancer [NCT00256334] | Phase 1 | 11 participants (Actual) | Interventional | 2005-07-31 | Completed | ||
| Evaluate the Effects of resVidaTM on Liver Fat Content, Body Fat Distribution and Insulin Sensitivity [NCT01635114] | 112 participants (Actual) | Interventional | 2012-06-30 | Completed | |||
| Effect of Resveratrol on Insulin Sensitivity and Metabolic Profile in Type 2 Diabetics [NCT01638780] | 24 participants (Anticipated) | Interventional | 2012-05-31 | Active, not recruiting | |||
| Interventional Pilot Study to Evaluate the Effect of a Resveratrol-based Nasal Spray Associated With Carboxymethylbetaglucan in Isotonic Solution in the Prevention of RTI in Children With Pre-school Wheezing [NCT05684848] | 252 participants (Anticipated) | Interventional | 2022-11-01 | Recruiting | |||
| Department of Nutrition and Food Hygiene,School of Public Health, Sun Yat-sen University [NCT04886297] | Phase 3 | 168 participants (Actual) | Interventional | 2021-05-01 | Completed | ||
| The Effects of Trans-Resveratrol (RSV) on Insulin Resistance, Inflammation, and the Metabolic Syndrome: A Placebo Controlled, Double-Blind Study. [NCT01714102] | 28 participants (Actual) | Interventional | 2012-10-31 | Completed | |||
| Open Label,Crossover,Pilot Study to Assess the Efficacy & Safety of Perispinal Admin.of Etanercept(Enbrel®) in Comb.w/Nutritional Supplements vs. Nutritional Supplements Alone in Subj. w/Mild to Mod. Alzheimer's Disease Receiving Std. Care. [NCT01716637] | Phase 1 | 12 participants (Anticipated) | Interventional | 2010-02-28 | Completed | ||
| Effects of Micronized Trans-resveratrol Treatment on Clinical, Endocrine, Metabolic and Biochemical Parameters of Women With Polycystic Ovary Syndrome: Placebo-controlled Randomized Single-blind Study [NCT01720459] | 40 participants (Anticipated) | Interventional | 2012-12-31 | Not yet recruiting | |||
| Randomized Three-way Cross-over Comparative Pharmacokinetic Study of Resveratrol Comprising Products in Fasting Healthy Subjects [NCT01747252] | 15 participants (Actual) | Interventional | 2012-08-31 | Completed | |||
| Association Between Fruitflow-II Treatment (Alone or in Combination With Resveratrol) and Changes in Cerebral Blood Flow, Fitness and Cognitive Function in Adults With Memory Complaints [NCT01766180] | 80 participants (Anticipated) | Interventional | 2013-01-31 | Recruiting | |||
| The Effects of the Dietary Supplement Trans-resveratrol on Heme Oxygenase-1 (HO-1) and Sirtuins Expression in PBMCs in Healthy Male Subjects: A Pilot Study. [NCT01768507] | 10 participants (Actual) | Interventional | 2011-03-31 | Completed | |||
| Effect of Resveratrol on Metabolic Parameters and Oocyte Quality in PCOS Patients Undergoing IVF Treatment. [NCT01782911] | 10 participants (Actual) | Interventional | 2013-02-01 | Completed | |||
| Effects of Trans-resveratrol on Cognitive Performance in Healthy, Young Humans: a Double-blind, Placebo-controlled, Crossover Investigation. [NCT01794351] | 50 participants (Actual) | Interventional | 2012-10-31 | Completed | |||
| Effects of High-Dose Resveratrol on Resting Energy Expenditure and HOMA in Non-Diabetic Obese Males [NCT02247596] | Phase 2 | 36 participants (Actual) | Interventional | 2009-07-31 | Completed | ||
| Influence of Caloric Restriction and Resveratrol in the Sirtuin System in Women and Men Aged 55 to 65 Years. [NCT01668836] | 48 participants (Actual) | Interventional | 2012-08-31 | Completed | |||
| The Effects of Chronic Trans- Resveratrol Supplementation on Aspects of Cognitive Performance, Mood, Sleep, Health and Cerebral Blood Flow in Healthy, Young Humans. [NCT01640197] | Phase 1 | 60 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
| Efficacy and Safety of Resveratrol in the Treatment of Depression: Double-blind Randomized Placebo-controlled Parallel-group Study. [NCT03384329] | Phase 4 | 30 participants (Actual) | Interventional | 2018-07-04 | Completed | ||
| A Randomized, 12 Months Follow-up, Dose-response, Placebo-Controlled, Double-Blind, 6-Arms Parallel Trial to Evaluate the Safety and Efficacy of a Resveratrol-enriched Grape Extract (Stilvid) in Primary and Secondary Patients of Cardiovascular Disease [NCT01449110] | Phase 2 | 150 participants (Actual) | Interventional | 2009-04-30 | Completed | ||
| Clinical Pharmacology and Target Validation of A Bioactive Dietary Polyphenol Preparation (BDPP) For Stress-Related Disorders [NCT04421079] | Phase 1 | 88 participants (Anticipated) | Interventional | 2021-01-19 | Recruiting | ||
| Phase IIa Study of Resveratrol to Enhance Mitochondrial and Physical Function in Older Adults [NCT02123121] | Phase 2 | 60 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| Effects of Resveratrol on Cerebral Blood Flow Parameters and Cognitive Performance in Humans: a Double-blind, Placebo-controlled, Crossover Investigation [NCT01010009] | 24 participants (Actual) | Interventional | 2008-06-30 | Completed | |||
| Regulation of Intestinal (and Hepatic) Lipoprotein Secretion by Resveratrol [NCT01451918] | Phase 2 | 8 participants (Actual) | Interventional | 2011-10-31 | Completed | ||
| Effects of Resveratrol in Patients With Type 2 Diabetes: The RED Trial [NCT01677611] | Phase 1 | 10 participants (Actual) | Interventional | 2008-12-31 | Completed | ||
| An Open Label Pilot Study to Evaluate the Effectiveness of Omega Q Plus® Resveratrol at Increasing Blood Levels of CoQ10 in Healthy Subjects and Subjects on Statins [NCT02415114] | Phase 1 | 50 participants (Anticipated) | Interventional | 2015-03-31 | Completed | ||
| Effects of Botanical Microglia Modulators in Gulf War Illness [NCT02909686] | 64 participants (Actual) | Interventional | 2016-07-31 | Completed | |||
| Resveratrol-Leucine Metabolite Synergy in Pre-diabetes [NCT01593605] | 36 participants (Actual) | Interventional | 2012-02-29 | Completed | |||
| A Pilot Randomized Controlled Clinical Trial of Resveratrol Supplementation on Exercise in Healthy Sedentary Adults [NCT01615445] | Phase 2 | 13 participants (Actual) | Interventional | 2009-02-28 | Completed | ||
| Effect of Resveratrol Administration on Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion [NCT02114892] | Phase 2 | 24 participants (Actual) | Interventional | 2012-04-30 | Completed | ||
| RESveratrol To Improve Outcomes in oldeR pEople With PAD (the RESTORE Trial) [NCT02246660] | 66 participants (Actual) | Interventional | 2015-01-31 | Completed | |||
| The Effects of Resveratrol and Acute Exercise on Endothelial Function in Postmenopausal Women [NCT02256540] | 25 participants (Actual) | Interventional | 2014-08-31 | Completed | |||
| Efficacy and Safety of Resveratrol and Lipoic Acid Transdermal Patch for Lipolysis in Overweight Volunteers [NCT03062163] | 66 participants (Actual) | Interventional | 2017-01-23 | Completed | |||
| Independent and Additive Effects Of Micronutrients With Metformin In Patients With PCOS:A Double Blind Randomized Placebo Controlled Trial [NCT05653895] | 250 participants (Anticipated) | Interventional | 2022-12-07 | Recruiting | |||
| Metabolic Intervention Using Resveratrol in Patients With Huntington Disease [NCT02336633] | 102 participants (Actual) | Interventional | 2015-07-31 | Completed | |||
| Effects of Supplementation With Resveratrol on Inflammation and Oxidative Stress of Non-dialysis Chronic Kidney Disease Patients [NCT02433925] | Phase 3 | 20 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| The Effects of Acute Trans-resveratrol Supplementation on Aspects of Cognitive Function and Cerebral Blood Flow, During Hypoxia and Normoxia, in Healthy, Young Humans. [NCT03100019] | 24 participants (Actual) | Interventional | 2014-05-13 | Completed | |||
| A Double-blind, Randomised, Placebo-controlled, Rising Multiple Dose Study in Healthy Volunteers to Investigate the Effect of BIA 6-512 at Steady-state on the Levodopa Pharmacokinetics When Administered in Combination With a Single-dose of Levodopa/Benser [NCT03097211] | Phase 1 | 38 participants (Actual) | Interventional | 2006-07-17 | Completed | ||
| An Open-label, Parallel-group Study to Compare the Pharmacokinetic Profile in Healthy Elderly Subjects Versus Healthy Young Subjects After Single and Repeated Oral Administration of BIA 6-512 (Trans-resveratrol) [NCT03095105] | Phase 1 | 25 participants (Actual) | Interventional | 2006-01-24 | Completed | ||
| A Double-blind, Randomised, Placebo-controlled, Rising Multiple-dose Study to Investigate the Tolerability and Steady-state Pharmacokinetics of BIA 6-512 (Trans-resveratrol) in Healthy Volunteers [NCT03093389] | Phase 1 | 40 participants (Actual) | Interventional | 2005-05-11 | Completed | ||
| Effect of Resveratrol on Insulin Resistance and Inflammatory Mediators in Obese and Type 2 Diabetic Subjects [NCT01158417] | 15 participants (Actual) | Interventional | 2008-12-31 | Terminated(stopped due to FDA clinical hold requiring IND submission, product not available in the market anymore) | |||
| The Use of Resveratrol for Pain in Endometriosis - A Clinical Trial [NCT02475564] | Phase 4 | 44 participants (Actual) | Interventional | 2015-06-30 | Completed | ||
| Randomized Double-Blind Placebo-Controlled Proof-of-Concept Trial of Resveratrol, a Plant Polyphenol, for the Outpatient Treatment of Mild Coronavirus Disease (COVID-19) [NCT04400890] | Phase 2 | 105 participants (Actual) | Interventional | 2020-09-13 | Terminated(stopped due to Feasibility) | ||
| Use of Resveratrol to Decrease Secondary Brain Injury Following Sports-Related Concussions: a Double-Blind, Placebo-Controlled Study [NCT01321151] | Phase 1/Phase 2 | 12 participants (Actual) | Interventional | 2011-03-31 | Completed | ||
| Impact of the Combined Treatment of Curcumin and Resveratrol Liposomed Polyphenols With G04CB02 on the Clinical Improvement of ALS Patients [NCT04654689] | Phase 2 | 90 participants (Actual) | Interventional | 2021-11-20 | Completed | ||
| Can SARS-CoV-2 Viral Shedding in COVID-19 Disease be Reduced by Resveratrol-assisted Zinc Ingestion, a Direct Inhibitor of SARS-CoV-2-RNA Polymerase? A Single Blinded Phase II Protocol (Reszinate Trial) [NCT04542993] | Phase 2 | 45 participants (Actual) | Interventional | 2020-09-08 | Terminated(stopped due to Difficulty accruing patients) | ||
| Resveratrol and Sirolimus in Lymphangioleiomyomatosis Trial (RESULT) [NCT03253913] | Phase 2 | 25 participants (Actual) | Interventional | 2018-03-31 | Completed | ||
| Investigation of the Efficacies of a Resveratrol Formula on Improvement of Skin [NCT04456829] | 60 participants (Actual) | Interventional | 2020-09-17 | Completed | |||
| Effect of Resveratrol and Vitamin C on Insulin Resistance and Antioxidant Capacity in Postmenopausal Women. A Randomized Clinical Trial [NCT03090997] | 45 participants (Anticipated) | Interventional | 2018-02-15 | Active, not recruiting | |||
| Dietary Inducers of Glyoxalase-1 for Prevention and Early-stage Alleviation of Age Related Health Disorders Through Functional Foods. [NCT02095873] | Phase 1/Phase 2 | 32 participants (Actual) | Interventional | 2014-05-31 | Completed | ||
| The Effects of Resveratrol on the Complications of Patients With Hemodialysis: a Prospective, Randomized, Double-blinded Clinical Trial [NCT03352895] | 36 participants (Actual) | Interventional | 2014-11-30 | Completed | |||
| ReNIM Study - Nebulized Resveratrol Plus Carboxymethyl-β-Glucan for Reducing Nasal Interleukin-5 (IL-5) Measurements in Children With Allergic Rhinitis [NCT03349619] | Phase 4 | 88 participants (Actual) | Interventional | 2018-03-05 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||