Cationic amino acid transporter 3

A cationic amino acid transporter 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WY07]

CAT-3;
CAT3;
Cationic amino acid transporter y+;
Solute carrier family 7 member 3

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
lysine	Homo sapiens (human)	IC50	158.0000	1	0
arginine	Homo sapiens (human)	IC50	283.0000	1	0

This protein enables 5 target(s):

Target	Category	Definition
L-ornithine transmembrane transporter activity	molecular function	Enables the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
amino acid transmembrane transporter activity	molecular function	Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
L-lysine transmembrane transporter activity	molecular function	Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
L-arginine transmembrane transporter activity	molecular function	Enables the transfer of L-arginine from one side of a membrane to the other. [GOC:dph, RHEA:32143]

This protein is located in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is involved in 7 target(s):

Target	Category	Definition
amino acid transport	biological process	The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
L-arginine import across plasma membrane	biological process	The directed movement of L-arginine from outside of a cell, across the plasma membrane and into the cytosol. [GOC:krc, PMID:8195186]
L-lysine import across plasma membrane	biological process	The directed movement of L-lysine from outside of a cell, across the plasma membrane and into the cytosol. [GOC:krc, PMID:8195186]
L-ornithine import across plasma membrane	biological process	The directed movement of L-ornithine from outside of a cell, across the plasma membrane and into the cytosol. [GOC:krc, PMID:8195186]
transport across blood-brain barrier	biological process	The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. [GOC:aruk, GOC:bc, PMID:29377008]
L-arginine transmembrane transport	biological process	The directed movement of L-arginine across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:18357653, PMID:22822152, PMID:8195186]
L-ornithine transmembrane transport	biological process	The directed movement of L-ornithine across a membrane. [GO_REF:0000069, GOC:krc, GOC:TermGenie, PMID:8195186]