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Gag-Pol polyprotein
A lentivirus-type gag-pol polyprotein that is encoded in the genome of Human immunodeficiency virus type 1 group M subtype B (isolate BH10). [PRO:DAN, UniProtKB:P03366]
Synonyms
Pr160Gag-Pol
Research
Bioassay Publications (7)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (71.43) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (3)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| nevirapine | Human immunodeficiency virus type 1 BH10 | IC50 | 17.2958 | 6 | 11 |
| 12-hydroxynevirapine | Human immunodeficiency virus type 1 BH10 | IC50 | 3.0000 | 1 | 1 |
| nsc 727447 | Human immunodeficiency virus type 1 BH10 | IC50 | 28.7750 | 1 | 4 |
De novo parallel design, synthesis and evaluation of inhibitors against the reverse transcriptase of human immunodeficiency virus type-1 and drug-resistant variants.Journal of medicinal chemistry, , May-17, Volume: 50, Issue:10, 2007
Novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 7. 8-Arylethyldipyridodiazepinones as potent broad-spectrum inhibitors of wild-type and mutant enzymes.Journal of medicinal chemistry, , Jul-30, Volume: 41, Issue:16, 1998
Novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 8. 8-Aryloxymethyl- and 8-arylthiomethyldipyridodiazepinones.Journal of medicinal chemistry, , Jul-30, Volume: 41, Issue:16, 1998
Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. 4. 2-Substituted dipyridodiazepinones as potent inhibitors of both wild-type and cysteine-181 HIV-1 reverse transcriptase enzymes.Journal of medicinal chemistry, , Nov-24, Volume: 38, Issue:24, 1995
Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase. 5. 4-Substituted and 2,4-disubstituted analogs of nevirapine.Journal of medicinal chemistry, , Nov-24, Volume: 38, Issue:24, 1995
Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. Tricyclic pyridobenzo- and dipyridodiazepinones.Journal of medicinal chemistry, , Volume: 34, Issue:7, 1991