Page last updated: 2024-08-07 12:48:41
Hypoxanthine-guanine phosphoribosyltransferase
A hypoxanthine-guanine phosphoribosyltransferase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00492]
Synonyms
HGPRT;
HGPRTase;
EC 2.4.2.8
Research
Bioassay Publications (4)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (11)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| chrysene | Homo sapiens (human) | Ki | 8.9800 | 1 | 1 |
| 6-chrysenamine | Homo sapiens (human) | Ki | 0.6000 | 1 | 1 |
| 6-nitrochrysene | Homo sapiens (human) | Ki | 6.7000 | 1 | 1 |
| guanosine monophosphate | Homo sapiens (human) | Ki | 5.8000 | 2 | 2 |
| inosinic acid | Homo sapiens (human) | Ki | 5.4000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| mercaptopurine | Homo sapiens (human) | Km | 2.0750 | 2 | 2 |
| thioguanine anhydrous | Homo sapiens (human) | Km | 3.8000 | 2 | 2 |
| guanine | Homo sapiens (human) | Km | 1.9000 | 2 | 2 |
| hypoxanthine | Homo sapiens (human) | Km | 3.2500 | 2 | 2 |
| allopurinol | Homo sapiens (human) | Km | 91.4500 | 2 | 2 |
| azaguanine | Homo sapiens (human) | Km | 72.0000 | 1 | 1 |
Enables
This protein enables 6 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleotide binding | molecular function | Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. [GOC:mah, ISBN:0198547684] |
| magnesium ion binding | molecular function | Binding to a magnesium (Mg) ion. [GOC:ai] |
| hypoxanthine phosphoribosyltransferase activity | molecular function | Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate. [EC:2.4.2.8, GOC:curators] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
| guanine phosphoribosyltransferase activity | molecular function | Catalysis of the reaction: GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate. [EC:2.4.2.8, GOC:curators] |
Located In
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Involved In
This protein is involved in 24 target(s):
| Target | Category | Definition |
|---|---|---|
| T cell mediated cytotoxicity | biological process | The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. [GOC:add, GOC:pr, ISBN:0781735149, PMID:11911826] |
| response to amphetamine | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine. [GOC:dph, GOC:ef] |
| purine nucleotide biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732] |
| purine ribonucleoside salvage | biological process | Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis. [GOC:jl] |
| guanine salvage | biological process | Any process that generates guanine, 2-amino-6-hydroxypurine, from derivatives of it without de novo synthesis. [GOC:jl] |
| grooming behavior | biological process | The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites. [GOC:jl, GOC:pr] |
| locomotory behavior | biological process | The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. [GOC:dph] |
| striatum development | biological process | The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] |
| cerebral cortex neuron differentiation | biological process | The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] |
| central nervous system neuron development | biological process | The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] |
| GMP salvage | biological process | Any process which produces guanosine monophosphate from derivatives of it, without de novo synthesis. [GOC:mah] |
| IMP salvage | biological process | Any process which produces inosine monophosphate from derivatives of it, without de novo synthesis. [GOC:mah] |
| dopamine metabolic process | biological process | The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. [GOC:jl, ISBN:0198506732] |
| hypoxanthine salvage | biological process | Any process that generates hypoxanthine, 6-hydroxy purine, from derivatives of it without de novo synthesis. [GOC:jl, ISBN:0198506732] |
| AMP salvage | biological process | The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from derivatives of it (either adenine, ADP or adenosine 3',5'-bisphosphate) without de novo synthesis. [GOC:ecd, GOC:jl, PMID:8917457, PMID:9864350] |
| positive regulation of dopamine metabolic process | biological process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving dopamine. [GOC:go_curators] |
| GMP catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of GMP, guanosine monophosphate. [GOC:go_curators] |
| IMP metabolic process | biological process | The chemical reactions and pathways involving IMP, inosine monophosphate. [GOC:go_curators] |
| adenine metabolic process | biological process | The chemical reactions and pathways involving adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine. [GOC:go_curators] |
| hypoxanthine metabolic process | biological process | The chemical reactions and pathways involving hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate. [GOC:go_curators] |
| lymphocyte proliferation | biological process | The expansion of a lymphocyte population by cell division. [GOC:ai] |
| dendrite morphogenesis | biological process | The process in which the anatomical structures of a dendrite are generated and organized. [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681] |
| protein homotetramerization | biological process | The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. [GOC:go_curators] |
| dopaminergic neuron differentiation | biological process | The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine. [GOC:rph] |