Mitochondrial 2-oxodicarboxylate carrier

A mitochondrial 2-oxodicarboxylate carrier that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BQT8]

Solute carrier family 25 member 21

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
eflornithine	Homo sapiens (human)	IC50	252.0000	1	1
allicin	Homo sapiens (human)	IC50	0.0110	1	1

This protein enables 2 target(s):

Target	Category	Definition
alpha-ketoglutarate transmembrane transporter activity	molecular function	Enables the transfer of alpha-ketoglutarate from one side of a membrane to the other. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle. [GOC:ai, ISBN:0198547684]
antiporter activity	molecular function	Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]

This protein is located in 1 target(s):

Target	Category	Definition
mitochondrial inner membrane	cellular component	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai]

This protein is involved in 3 target(s):

Target	Category	Definition
lysine catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid. [GOC:go_curators]
lipid transport	biological process	The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. [ISBN:0198506732]
mitochondrial alpha-ketoglutarate transmembrane transport	biological process	The process in which alpha-ketoglutarate is transported across a mitochondrial membrane, into or out of the mitochondrion. [PMID:11013234, PMID:20371607]