N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

An N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O94760]

Synonyms

DDAH-1;
Dimethylarginine dimethylaminohydrolase 1;
EC 3.5.3.18;
DDAHI;
Dimethylargininase-1

Research

Bioassay Publications (8)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (50.00)	29.6817
2010's	3 (37.50)	24.3611
2020's	1 (12.50)	2.80

Compounds (18)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
lansoprazole	Homo sapiens (human)	IC50	51.0000	1	0
omeprazole	Homo sapiens (human)	IC50	20.0000	1	0
pantoprazole	Homo sapiens (human)	IC50	63.0000	1	0
rabeprazole	Homo sapiens (human)	IC50	53.0000	1	1
citrulline	Homo sapiens (human)	Ki	2,350.0000	1	2
2-ethylbenzimidazole	Homo sapiens (human)	IC50	1,400.0000	1	1
2-ethylbenzimidazole	Homo sapiens (human)	Ki	800.0000	1	1
1,2-benzisothiazoline-3-one	Homo sapiens (human)	IC50	13.2000	1	0
homocysteine	Homo sapiens (human)	IC50	640.0000	1	1
s-methylthiocitrulline	Homo sapiens (human)	Ki	0.0500	1	1
n(g)-iminoethylornithine	Homo sapiens (human)	Ki	715.5667	2	3
n,n-dimethylarginine	Homo sapiens (human)	Ki	0.7000	1	1
omega-n-methylarginine	Homo sapiens (human)	Ki	604.6000	1	5
delta-n-methylarginine	Homo sapiens (human)	IC50	5,000.0000	1	1
nitroarginine	Homo sapiens (human)	Ki	1,968.0000	1	1
vinyl-l-nio	Homo sapiens (human)	IC50	13.0000	1	1
vinyl-l-nio	Homo sapiens (human)	Ki	2.0000	3	3
tenatoprazole	Homo sapiens (human)	IC50	7.8000	1	0
pd 404182	Homo sapiens (human)	IC50	8.7140	1	0
omega-n-allylarginine	Homo sapiens (human)	IC50	207.0000	1	1
omega-n-allylarginine	Homo sapiens (human)	Ki	58.0000	2	2

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
s-methylthiocitrulline	Homo sapiens (human)	Km	15.0000	1	1
n,n-dimethylarginine	Homo sapiens (human)	Km	260.0000	2	2
omega-n-methylarginine	Homo sapiens (human)	Km	128.6667	3	3

Enables

This protein enables 4 target(s):

Target	Category	Definition
catalytic activity	molecular function	Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. [GOC:vw, ISBN:0198506732]
dimethylargininase activity	molecular function	Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline. [EC:3.5.3.18]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
amino acid binding	molecular function	Binding to an amino acid, organic acids containing one or more amino substituents. [GOC:ai]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Involved In

This protein is involved in 11 target(s):

Target	Category	Definition
citrulline metabolic process	biological process	The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins. [ISBN:0198506732]
regulation of systemic arterial blood pressure	biological process	The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. [GOC:mtg_cardio]
arginine catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. [GOC:go_curators]
nitric oxide mediated signal transduction	biological process	An intracellular signaling cassette that starts with production of nitric oxide, detection by receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and ends with the activation of downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms. [GOC:jl, PMID:21549190]
negative regulation of cell population proliferation	biological process	Any process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators]
negative regulation of vascular permeability	biological process	Any process that reduces the extent to which blood vessels can be pervaded by fluid. [GOC:jl]
positive regulation of nitric oxide biosynthetic process	biological process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. [GOC:go_curators]
positive regulation of angiogenesis	biological process	Any process that activates or increases angiogenesis. [GOC:go_curators]
nitric oxide metabolic process	biological process	The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water. [GOC:ai]
negative regulation of cellular response to hypoxia	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hypoxia. [GOC:TermGenie, GOC:yaf]
arginine metabolic process	biological process	The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. [GOC:go_curators]