Page last updated: 2024-08-07 15:30:42
Dihydrofolate reductase type 1
A protein that is a translation product of any of the plasmid-encoded copies of the dhfrI gene in Escherichia coli. [PRO:DAN, UniProtKB:P00382]
Synonyms
EC 1.5.1.3;
Dihydrofolate reductase type I;
Trimethoprim resistance protein
Research
Bioassay Publications (4)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (2)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| trimethoprim | Escherichia coli | IC50 | 0.2500 | 2 | 2 |
| epiroprim | Escherichia coli | Ki | 0.0219 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| trimethoprim | Escherichia coli | C50 | 550,000.0000 | 1 | 1 |