A trypsin-2 that is encoded in the genome of human. [PRO:DAN, UniProtKB:P07478]
EC 3.4.21.4;
Anionic trypsinogen;
Serine protease 2;
Trypsin II
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (8.57) | 18.2507 |
| 2000's | 18 (51.43) | 29.6817 |
| 2010's | 13 (37.14) | 24.3611 |
| 2020's | 1 (2.86) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 3-nitrobenzeneboronic acid | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| 5-(n,n-hexamethylene)amiloride | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| benzo(b)thiophene-2-boronic acid | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| bis(5-amidino-2-benzimidazolyl)methane | Homo sapiens (human) | IC50 | 4.4000 | 1 | 1 |
| bis(5-amidino-2-benzimidazolyl)methane | Homo sapiens (human) | Ki | 9.5450 | 2 | 2 |
| camostat | Homo sapiens (human) | IC50 | 0.0035 | 1 | 1 |
| n(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide | Homo sapiens (human) | IC50 | 0.1690 | 1 | 1 |
| sulfaguanidine | Homo sapiens (human) | Ki | 1.3500 | 1 | 1 |
| isoquinoline-1,3,4-trione | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| amiloride | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| baicalin | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| leupeptin | Homo sapiens (human) | IC50 | 0.6000 | 1 | 1 |
| mci 9038 | Homo sapiens (human) | Ki | 1.9900 | 1 | 1 |
| sivelestat | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| dx 9065 | Homo sapiens (human) | IC50 | 3.2000 | 1 | 1 |
| dx 9065 | Homo sapiens (human) | Ki | 0.6200 | 2 | 2 |
| skullcapflavone ii | Homo sapiens (human) | IC50 | 110.0000 | 1 | 1 |
| n-dansyl-3-aminobenzeneboronic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| melagatran | Homo sapiens (human) | IC50 | 0.0119 | 1 | 2 |
| melagatran | Homo sapiens (human) | Ki | 0.0043 | 1 | 1 |
| razaxaban | Homo sapiens (human) | Ki | 6.9714 | 7 | 7 |
| dabigatran | Homo sapiens (human) | Ki | 0.0502 | 2 | 2 |
| 1-(2-Naphthylmethyl)-2,3-dioxo-indoline-5-carboxamide | Homo sapiens (human) | IC50 | 352.0000 | 1 | 1 |
| wogonoside | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| silybin | Homo sapiens (human) | IC50 | 3.7000 | 1 | 1 |
| ganhuangenin | Homo sapiens (human) | IC50 | 88.0000 | 1 | 1 |
| quercetin | Homo sapiens (human) | IC50 | 15.4000 | 1 | 1 |
| baicalein | Homo sapiens (human) | IC50 | 3.7000 | 1 | 1 |
| wogonin | Homo sapiens (human) | IC50 | 105.0000 | 1 | 1 |
| 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one | Homo sapiens (human) | IC50 | 61.0000 | 1 | 1 |
| bms 740808 | Homo sapiens (human) | Ki | 2.8000 | 2 | 2 |
| bms-262084 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| dpc 423 | Homo sapiens (human) | Ki | 0.0600 | 2 | 2 |
| gw 813893 | Homo sapiens (human) | IC50 | 158.0000 | 1 | 1 |
| l 374087 | Homo sapiens (human) | Ki | 3.2000 | 1 | 1 |
| darexaban | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| lb 30057 | Homo sapiens (human) | Ki | 3.2900 | 1 | 1 |
| darexaban glucuronide | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| apixaban | Homo sapiens (human) | Ki | 4.2000 | 1 | 1 |
| rpx7009 | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
This protein enables 5 target(s):
| Target | Category | Definition |
|---|---|---|
| metalloendopeptidase activity | molecular function | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE] |
| serine-type endopeptidase activity | molecular function | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] |
| calcium ion binding | molecular function | Binding to a calcium ion (Ca2+). [GOC:ai] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| serine-type peptidase activity | molecular function | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] |
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
| extracellular matrix | cellular component | A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324] |
| azurophil granule lumen | cellular component | The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. [GOC:bf, PMID:17152095] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
This protein is involved in 7 target(s):
| Target | Category | Definition |
|---|---|---|
| proteolysis | biological process | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah] |
| digestion | biological process | The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. [GOC:isa_complete, ISBN:0198506732] |
| antimicrobial humoral response | biological process | An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus. [GOC:go_curators, GOC:mtg_sensu] |
| extracellular matrix disassembly | biological process | A process that results in the breakdown of the extracellular matrix. [GOC:jid] |
| positive regulation of cell growth | biological process | Any process that activates or increases the frequency, rate, extent or direction of cell growth. [GOC:go_curators] |
| collagen catabolic process | biological process | The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells. [GOC:mah, ISBN:0815316194] |
| positive regulation of cell adhesion | biological process | Any process that activates or increases the frequency, rate or extent of cell adhesion. [GOC:go_curators] |