Cytochrome P450 1A1

A cytochrome P450 1A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P04798]

Synonyms

CYPIA1;
EC 1.14.14.1;
Cytochrome P450 form 6;
Cytochrome P450-C;
Cytochrome P450-P1;
Hydroperoxy icosatetraenoate dehydratase;
4.2.1.152

Research

Bioassay Publications (37)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (10.81)	29.6817
2010's	25 (67.57)	24.3611
2020's	8 (21.62)	2.80

Compounds (70)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
melatonin	Homo sapiens (human)	Ki	59.0000	1	1
5-methoxypsoralen	Homo sapiens (human)	IC50	0.0800	1	1
5-methoxypsoralen	Homo sapiens (human)	Ki	0.0600	1	1
beta-naphthoflavone	Homo sapiens (human)	IC50	0.0540	1	1
ellipticine	Homo sapiens (human)	IC50	0.0193	1	1
emodin	Homo sapiens (human)	IC50	12.2500	1	1
furafylline	Homo sapiens (human)	Ki	200.0000	1	1
khellin	Homo sapiens (human)	IC50	4.0200	1	1
khellin	Homo sapiens (human)	Ki	3.8000	1	1
nisoxetine	Homo sapiens (human)	IC50	0.0079	1	1
1,4-phenylenebis(methylene)selenocyanate	Homo sapiens (human)	IC50	0.1000	1	1
purpurin	Homo sapiens (human)	IC50	5.5000	1	1
1,3-diphenyl-1-triazene	Homo sapiens (human)	IC50	8.0000	1	1
naphthazarin	Homo sapiens (human)	IC50	3.8200	1	1
naphthazarin	Homo sapiens (human)	Ki	3.6600	1	1
plumbagin	Homo sapiens (human)	IC50	2.7700	1	1
plumbagin	Homo sapiens (human)	Ki	2.5600	1	1
alpha-naphthoflavone	Homo sapiens (human)	IC50	2.4555	26	26
alpha-naphthoflavone	Homo sapiens (human)	Ki	0.0450	1	1
tranylcypromine	Homo sapiens (human)	IC50	6.2000	1	1
pyrene	Homo sapiens (human)	IC50	0.0410	2	2
4,5'-dimethylangelicin	Homo sapiens (human)	Ki	37.9000	1	1
proadifen hydrochloride	Homo sapiens (human)	IC50	19.0000	1	1
rutecarpine	Homo sapiens (human)	IC50	0.2600	1	1
2-methoxyestradiol	Homo sapiens (human)	Ki	62.0000	2	2
pinocembrin	Homo sapiens (human)	IC50	7.9060	1	1
isopimpinellin	Homo sapiens (human)	IC50	0.0200	1	1
isopimpinellin	Homo sapiens (human)	Ki	0.0120	1	1
5-hydroxyflavone	Homo sapiens (human)	IC50	4.0300	1	1
4-methoxyestradiol	Homo sapiens (human)	Ki	149.0000	1	1
pirlindole	Homo sapiens (human)	IC50	36.0000	1	1
hesperetin	Homo sapiens (human)	IC50	2.7860	1	1
homoeriodictyol	Homo sapiens (human)	IC50	11.5545	2	2
eupatorin	Homo sapiens (human)	Ki	0.2100	1	1
phellopterin	Homo sapiens (human)	IC50	0.5800	1	1
phellopterin	Homo sapiens (human)	Ki	0.6200	1	1
karanjin	Homo sapiens (human)	IC50	1.3650	2	2
benzyl selenocyanate	Homo sapiens (human)	IC50	0.1000	1	1
5-hydroxy-3',4',6,7-tetramethoxyflavone	Homo sapiens (human)	IC50	1.3800	1	1
5-hydroxy-3',4',6,7-tetramethoxyflavone	Homo sapiens (human)	Ki	1.4200	1	1
cirsiliol	Homo sapiens (human)	Ki	0.8000	1	1
isosakuranetin	Homo sapiens (human)	IC50	2.1960	1	1
naringenin	Homo sapiens (human)	IC50	15.1670	1	1
eriodictyol	Homo sapiens (human)	IC50	10.9730	1	1
resveratrol	Homo sapiens (human)	IC50	22.6667	3	3
cannabidiol	Homo sapiens (human)	Ki	0.1600	1	1
pongamol	Homo sapiens (human)	IC50	2.2300	1	1
pongamol	Homo sapiens (human)	Ki	1.9600	1	1
uccf-029	Homo sapiens (human)	IC50	0.0187	1	1
quercetin	Homo sapiens (human)	IC50	8.4364	5	5
quercetin	Homo sapiens (human)	Ki	0.6600	1	1
formononetin	Homo sapiens (human)	IC50	100.0000	1	1
acacetin	Homo sapiens (human)	IC50	0.0830	2	2
acacetin	Homo sapiens (human)	Ki	0.0450	1	1
apigenin	Homo sapiens (human)	IC50	0.4270	1	1
apigenin	Homo sapiens (human)	Ki	0.3900	1	1
luteolin	Homo sapiens (human)	IC50	1.2490	1	1
luteolin	Homo sapiens (human)	Ki	1.8967	2	3
chrysoeriol	Homo sapiens (human)	IC50	0.0948	2	2
kaempferol	Homo sapiens (human)	IC50	0.6320	1	1
kaempferol	Homo sapiens (human)	Ki	0.7500	1	1
baicalein	Homo sapiens (human)	Ki	1.2200	1	1
chrysin	Homo sapiens (human)	IC50	0.7215	2	2
chrysin	Homo sapiens (human)	Ki	0.0420	1	1
diosmetin	Homo sapiens (human)	IC50	0.1400	1	1
diosmetin	Homo sapiens (human)	Ki	0.0890	1	1
galangin	Homo sapiens (human)	IC50	0.0770	1	1
genkwanin	Homo sapiens (human)	Ki	2.3400	1	1
3-methylquercetin	Homo sapiens (human)	IC50	0.0560	1	1
kaempferide	Homo sapiens (human)	IC50	0.1940	2	2
myricetin	Homo sapiens (human)	Ki	0.3700	1	1
scutellarein	Homo sapiens (human)	Ki	1.6400	1	1
tamarixetin	Homo sapiens (human)	IC50	0.1200	1	1
trans-2,3',4,5'-tetrahydroxystilbene	Homo sapiens (human)	IC50	15.0000	1	1
pterostilbene	Homo sapiens (human)	Ki	0.5700	1	2
2,4,3',5'-tetramethoxystilbene	Homo sapiens (human)	IC50	0.3000	3	3
3,3',4,5'-tetramethoxy-trans-stilbene	Homo sapiens (human)	IC50	0.7500	1	1
3,4',5-trimethoxystilbene	Homo sapiens (human)	IC50	0.8300	1	1
pinostilbene	Homo sapiens (human)	Ki	0.1300	1	2
3,5-dihydroxy-4'-methoxystilbene	Homo sapiens (human)	Ki	0.1600	1	2
eupatorin-5-methyl ether	Homo sapiens (human)	Ki	0.6300	1	1
pifithrin-alpha	Homo sapiens (human)	IC50	1.5000	1	1
cannabidivarin	Homo sapiens (human)	IC50	0.0600	1	1
cannabidivarin	Homo sapiens (human)	Ki	1.6000	1	1
kaf156	Homo sapiens (human)	IC50	6.0000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
acetaminophen	Homo sapiens (human)	Kd	19.1000	1	1
alpha-naphthoflavone	Homo sapiens (human)	EC50	2.5000	2	2
isopimpinellin	Homo sapiens (human)	EC50	13.8000	1	1
quercetin	Homo sapiens (human)	EC50	8.8000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
acetaminophen	Homo sapiens (human)	Km	803.0000	1	1
17-dihydroexemestane	Homo sapiens (human)	Km	28.6200	1	1

Enables

This protein enables 20 target(s):

Target	Category	Definition
monooxygenase activity	molecular function	Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. [ISBN:0198506732]
iron ion binding	molecular function	Binding to an iron (Fe) ion. [GOC:ai]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
arachidonic acid monooxygenase activity	molecular function	Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water. [GOC:mah]
oxidoreductase activity	molecular function	Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. [GOC:go_curators]
oxidoreductase activity, acting on diphenols and related substances as donors	molecular function	Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]
flavonoid 3'-monooxygenase activity	molecular function	Catalysis of the reaction: a flavonoid + NADPH + H+ + O2 = 3'-hydroxyflavonoid + NADP+ + H2O. [EC:1.14.14.82]
oxygen binding	molecular function	Binding to oxygen (O2). [GOC:jl]
enzyme binding	molecular function	Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
heme binding	molecular function	Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:ai]
Hsp70 protein binding	molecular function	Binding to a Hsp70 protein, heat shock proteins around 70kDa in size. [ISBN:0198506732]
demethylase activity	molecular function	Catalysis of the removal of a methyl group from a substrate. [GOC:mah]
Hsp90 protein binding	molecular function	Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size. [GOC:ai]
aromatase activity	molecular function	Catalysis of the reduction of an aliphatic ring to yield an aromatic ring. [GOC:cb]
vitamin D 24-hydroxylase activity	molecular function	Catalysis of the hydroxylation of C-24 of any form of vitamin D. [GOC:BHF, GOC:mah, PMID:15546903]
estrogen 16-alpha-hydroxylase activity	molecular function	Catalysis of the reaction: estrogen + donor-H2 + O2 = 16-alpha-hydroxyestrogen + H2O. [GOC:BHF]
estrogen 2-hydroxylase activity	molecular function	Catalysis of the reaction: estrogen + donor-H2 + O2 = 2-hydroxyestrogen + H2O. [GOC:BHF, GOC:rl, PMID:14559847]
long-chain fatty acid omega-hydroxylase activity	molecular function	Catalysis of the reaction: an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. [GOC:krc, PMID:18544608, RHEA:56748]
hydroperoxy icosatetraenoate dehydratase activity	molecular function	A hydroperoxy icosatetraenoate = an oxoicosatetraenoate + H2O. [PMID:12881489, RHEA:55556]
long-chain fatty acid omega-1 hydroxylase activity	molecular function	Catalysis of the reaction: an (omega-1)-ethyl long-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an (omega-1)-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase. [GOC:nhn, PMID:18577768, PMID:22772592, PMID:24242247, RHEA:60936]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
mitochondrial inner membrane	cellular component	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai]
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
intracellular membrane-bounded organelle	cellular component	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]

Involved In

This protein is involved in 40 target(s):

Target	Category	Definition
response to hypoxia	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:hjd]
long-chain fatty acid metabolic process	biological process	The chemical reactions and pathways involving a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [GOC:ajp]
lipid hydroxylation	biological process	The covalent attachment of a hydroxyl group to one or more fatty acids in a lipid. [GOC:hjd, PMID:15658937]
fatty acid metabolic process	biological process	The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198547684]
steroid biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. [GOC:go_curators]
porphyrin-containing compound metabolic process	biological process	The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. [GOC:jl, ISBN:0198506732, Wikipedia:Porphyrin#Natural_formation]
xenobiotic metabolic process	biological process	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc]
steroid metabolic process	biological process	The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [ISBN:0198547684]
estrogen metabolic process	biological process	The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. [ISBN:0198506732]
amine metabolic process	biological process	The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. [GOC:jl, ISBN:0198506732]
response to nematode	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a nematode. [GOC:hb]
response to herbicide	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants. [GOC:curators]
ethylene metabolic process	biological process	The chemical reactions and pathways involving ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator. [ISBN:0387969845]
coumarin metabolic process	biological process	The chemical reactions and pathways involving coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids. [GOC:lr, GOC:yl]
flavonoid metabolic process	biological process	The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins. [GOC:tair_curators, ISBN:0198547684]
response to iron(III) ion	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus. [GOC:sm]
insecticide metabolic process	biological process	The chemical reactions and pathways involving insecticides, chemicals used to kill insects. [GOC:ai]
dibenzo-p-dioxin catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. [GOC:ai]
epoxygenase P450 pathway	biological process	The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids. [GOC:mah, PMID:17979511]
response to food	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat. [GOC:add, ISBN:0721601464]
response to lipopolysaccharide	biological process	Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:add, ISBN:0721601464]
response to vitamin A	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus. [GOC:sl]
response to immobilization stress	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile. [GOC:bf, PMID:17683801, PMID:19893991]
vitamin D metabolic process	biological process	The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). [GOC:mah, ISBN:0471331309]
retinol metabolic process	biological process	The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551]
long-chain fatty acid biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [PMID:18390550]
9-cis-retinoic acid biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of 9-cis-retinoic acid, a metabolically active vitamin A derivative. [GOC:jl, PMID:11279029]
camera-type eye development	biological process	The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. [GOC:go_curators, GOC:mtg_sensu]
nitric oxide metabolic process	biological process	The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water. [GOC:ai]
response to arsenic-containing substance	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. [GOC:hjd, ISBN:0721662544]
digestive tract development	biological process	The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed. [GOC:go_curators]
tissue remodeling	biological process	The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling. [GOC:ebc]
hydrogen peroxide biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. [GOC:ai]
response to hyperoxia	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension. [GOC:kmv]
maternal process involved in parturition	biological process	A reproductive process occurring in the mother that results in birth. [GOC:dph]
hepatocyte differentiation	biological process	The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver. [CL:0000182, PMID:7588884]
cellular response to copper ion	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus. [GOC:mah]
omega-hydroxylase P450 pathway	biological process	The chemical reactions and pathways by which arachidonic acid is converted to other compounds initially by omega-hydroxylation. [GOC:mw, PMID:10681399]
positive regulation of G1/S transition of mitotic cell cycle	biological process	Any signaling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. [GOC:mtg_cell_cycle]
response to 3-methylcholanthrene	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3-methylcholanthrene stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:9224771]