RNA-directed RNA polymerase

Drug	Measurement	Average (mM)	Bioassay(s)	Publication(s)
cordycepin	IC50	22.0000	1	1
meconic acid	IC50	72.6667	3	3
vidarabine	IC50	50.0000	1	1
acetylpyruvic acid	IC50	50.0000	1	1
3'-deoxyadenosine 5'-triphosphate	IC50	8.8000	1	1
2-Oxo-4-phenylbutyric acid	IC50	50.0000	1	1
corilagin	IC50	20.0000	1	1
2'-fluoro-2'-deoxyadenosine	IC50	50.0000	1	1
2'-o-methyladenosine	IC50	47.0000	1	1
3'-fluoro-3'-deoxyadenosine	IC50	28.0000	1	1
3'-deoxycytidine 5'-triphosphate	IC50	0.7700	1	1
3'-c-methyladenosine	IC50	50.0000	1	1
4-phenyl-4-oxo-2-hydroxybuten-2-oic acid	IC50	5.7000	1	1
2'-c-methyladenosine	IC50	1.9000	1	1
psi 6130	IC50	56.7000	1	1
hcv 796	IC50	0.1600	1	1
GS-441524	IC50	5.6000	1	1
gsk2485852	IC50	0.1300	1	1
deleobuvir	IC50	0.0190	1	0
2'-o-methylguanosine	IC50	1.6000	1	1
3-deoxyguanosine	IC50	0.6000	1	1

Drug	Measurement	Average (mM)	Bioassay(s)	Publication(s)
cordycepin	EC50	46.0000	1	1
vidarabine	EC50	50.0000	1	1
2'-fluoro-2'-deoxyadenosine	EC50	50.0000	1	1
2'-o-methyladenosine	EC50	50.0000	1	1
3'-fluoro-3'-deoxyadenosine	EC50	1.2000	1	1
3'-c-methyladenosine	EC50	50.0000	1	1
2'-c-methyladenosine	EC50	0.3000	1	1
2'-c-methylcytidine	EC50	2.8000	1	1
alisporivir	EC50	0.0158	1	1
hcv 796	EC50	0.0266	5	5
tegobuvir	EC50	0.0029	2	2
lomibuvir	EC50	0.2090	5	5
sofosbuvir	EC50	0.1454	12	12
abt-333	EC50	0.0018	1	1
deleobuvir	EC50	0.0170	2	0
2'-o-methylguanosine	EC50	50.0000	1	1
2'-deoxy-2'-fluoroguanosine	EC50	50.0000	1	1
3-deoxyguanosine	EC50	50.0000	1	1

Drug	Measurement	Average (mM)	Bioassay(s)	Publication(s)
uridine triphosphate	Km	10.2950	4	4
cytidine triphosphate	Km	2.7000	1	1
2'-c-methylcytidine	EC90	9.9000	1	1
sofosbuvir	EC90	0.8343	7	7

Recent advancement in small molecules as HCV inhibitors.
Bioorganic & medicinal chemistry, , 04-15, Volume: 60, 2022

Use of 2'-spirocyclic ethers in HCV nucleoside design.
Journal of medicinal chemistry, , Mar-13, Volume: 57, Issue:5, 2014

[no title available]
Journal of medicinal chemistry, , 04-22, Volume: 64, Issue:8, 2021

Research