An alpha-(1,3)-fucosyltransferase 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q11130]
EC 2.4.1.-;
Fucosyltransferase 7;
Fucosyltransferase VII;
Fuc-TVII;
FucT-VII;
Galactoside 3-L-fucosyltransferase;
Selectin ligand synthase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 2,3-dihydroxybenzoic acid | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| protocatechuic acid | Homo sapiens (human) | IC50 | 137.0000 | 1 | 1 |
| gallic acid | Homo sapiens (human) | IC50 | 65.0086 | 1 | 7 |
| beta-resorcylic acid | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| 2,5-dihydroxybenzoic acid | Homo sapiens (human) | IC50 | 115.0000 | 1 | 1 |
| veratric acid | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| methyl gallate | Homo sapiens (human) | IC50 | 26.5000 | 1 | 2 |
| 3,4,5-trimethoxybenzoic acid | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| syringic acid | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| epigallocatechin gallate | Homo sapiens (human) | IC50 | 7.2833 | 1 | 6 |
| guanosine diphosphate | Homo sapiens (human) | IC50 | 125.2600 | 1 | 5 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| fucosyltransferase activity | molecular function | Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. [GOC:ai] |
| 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity | molecular function | Catalysis of the reaction: GDP-beta-L-fucose + beta-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R = GDP + 1,4-beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,3)]-N-acetyl-D-glucosaminyl-R. [EC:2.4.1.152, RHEA:14257] |
| alpha-(1->3)-fucosyltransferase activity | molecular function | Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage. [GOC:ai] |
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| Golgi membrane | cellular component | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah] |
| Golgi apparatus | cellular component | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732] |
| trans-Golgi network | cellular component | The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. [GOC:vw, ISBN:0815316194] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| Golgi cisterna membrane | cellular component | The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. [GOC:ecd, GOC:mah] |
This protein is involved in 24 target(s):
| Target | Category | Definition |
|---|---|---|
| regulation of type IV hypersensitivity | biological process | Any process that modulates the frequency, rate, or extent of type IV hypersensitivity, a type of inflammatory response. [GOC:add, ISBN:0781735149] |
| CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation | biological process | The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell. [GOC:add, PMID:15207821] |
| leukocyte migration involved in immune response | biological process | The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response. [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] |
| leukocyte migration involved in inflammatory response | biological process | The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response. [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] |
| protein glycosylation | biological process | A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. [GOC:curators, GOC:pr] |
| ceramide metabolic process | biological process | The chemical reactions and pathways involving ceramides, any N-acylated sphingoid. [ISBN:0198547684] |
| inflammatory response | biological process | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732] |
| embryo implantation | biological process | Attachment of the blastocyst to the uterine lining. [GOC:isa_complete, http://www.medterms.com] |
| oligosaccharide biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. [ISBN:0198506732] |
| regulation of cell-cell adhesion | biological process | Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. [GOC:isa_complete] |
| positive regulation of cell-cell adhesion | biological process | Any process that activates or increases the rate or extent of cell adhesion to another cell. [GOC:isa_complete] |
| L-fucose catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of L-fucose (6-deoxy-Lgalactose). [GOC:jl] |
| positive regulation of cell adhesion | biological process | Any process that activates or increases the frequency, rate or extent of cell adhesion. [GOC:go_curators] |
| regulation of insulin receptor signaling pathway | biological process | Any process that modulates the frequency, rate or extent of insulin receptor signaling. [GOC:bf] |
| regulation of cell adhesion molecule production | biological process | Any process that modulates the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism. [GOC:BHF, GOC:rl] |
| T cell migration | biological process | The movement of a T cell within or between different tissues and organs of the body. [CL:0000084, GOC:BHF, GOC:mah] |
| lymphocyte migration into lymph node | biological process | The movement of a lymphocyte within the lymphatic system into a lymph node, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen. [GOC:BHF, GOC:pr, PMID:18379575] |
| positive regulation of neutrophil migration | biological process | Any process that activates or increases the frequency, rate or extent of neutrophil migration. [GO_REF:0000058, GOC:TermGenie, PMID:1826836] |
| regulation of leukocyte cell-cell adhesion | biological process | Any process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532] |
| regulation of leukocyte tethering or rolling | biological process | Any process that modulates the frequency, rate or extent of leukocyte tethering or rolling. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18308860] |
| positive regulation of leukocyte tethering or rolling | biological process | Any process that activates or increases the frequency, rate or extent of leukocyte tethering or rolling. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18308860] |
| positive regulation of leukocyte adhesion to vascular endothelial cell | biological process | Any process that activates or increases the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23897866] |
| regulation of neutrophil extravasation | biological process | Any process that modulates the frequency, rate or extent of neutrophil extravasation. [GOC:mah] |
| fucosylation | biological process | The covalent attachment of a fucosyl group to an acceptor molecule. [GOC:sart, PMID:19948734] |