Proteins > 5-hydroxytryptamine receptor 2A
Page last updated: 2024-08-07 13:20:37
5-hydroxytryptamine receptor 2A
A 5-hydroxytryptamine receptor 2A that is encoded in the genome of pig. [OMA:P50129, PRO:DNx]
Synonyms
5-HT-2;
5-HT-2A;
5-HT2A;
Serotonin receptor 2A
Research
Bioassay Publications (7)
Timeframe | Studies on this Protein(%) | All Drugs % |
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 5 (71.43) | 29.6817 |
2010's | 2 (28.57) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Compounds (6)
Drugs with Inhibition Measurements
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
haloperidol | Sus scrofa (pig) | Ki | 0.0300 | 1 | 1 |
quinpirole | Sus scrofa (pig) | Ki | 0.0490 | 1 | 1 |
f 13640 | Sus scrofa (pig) | Ki | 23.0000 | 1 | 1 |
fauc 346 | Sus scrofa (pig) | Ki | 0.3500 | 1 | 1 |
fauc 213 | Sus scrofa (pig) | Ki | 0.9000 | 2 | 2 |
fauc 113 | Sus scrofa (pig) | Ki | 0.3800 | 2 | 2 |
Drugs with Activation Measurements
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
quinpirole | Sus scrofa (pig) | EC50 | 0.0034 | 1 | 1 |
1,1'-Disubstituted ferrocenes as molecular hinges in mono- and bivalent dopamine receptor ligands.Journal of medicinal chemistry, , Nov-12, Volume: 52, Issue:21, 2009
Synthesis and biological investigations of dopaminergic partial agonists preferentially recognizing the D4 receptor subtype.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 16, Issue:11, 2006
Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET.Journal of medicinal chemistry, , Mar-27, Volume: 51, Issue:6, 2008
Discovery of a dopamine D4 selective PET ligand candidate taking advantage of a click chemistry based REM linker.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET.Journal of medicinal chemistry, , Mar-27, Volume: 51, Issue:6, 2008
2-[(4-phenylpiperazin-1-yl)methyl]imidazo(di)azines as selective D4-ligands. Induction of penile erection by 2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine (PIP3EA), a potent and selective D4 partial agonist.Journal of medicinal chemistry, , Jun-29, Volume: 49, Issue:13, 2006