Proteins > Muscarinic acetylcholine receptor M4
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Muscarinic acetylcholine receptor M4
A muscarinic acetylcholine receptor M4 that is encoded in the genome of rat. [OMA:P08485, PRO:DNx]
Synonyms
Research
Bioassay Publications (71)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 15 (21.13) | 18.7374 |
| 1990's | 36 (50.70) | 18.2507 |
| 2000's | 10 (14.08) | 29.6817 |
| 2010's | 10 (14.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (176)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| quinacrine | Rattus norvegicus (Norway rat) | IC50 | 4.5000 | 1 | 1 |
| ro 5-4864 | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 5,8,11,14-eicosatetraynoic acid | Rattus norvegicus (Norway rat) | IC50 | 1.7800 | 1 | 0 |
| tacrine | Rattus norvegicus (Norway rat) | IC50 | 6.6000 | 2 | 2 |
| aceclidine | Rattus norvegicus (Norway rat) | IC50 | 0.5100 | 1 | 1 |
| aceclidine | Rattus norvegicus (Norway rat) | Ki | 8.2600 | 1 | 1 |
| methacholine | Rattus norvegicus (Norway rat) | IC50 | 0.7000 | 1 | 1 |
| methacholine | Rattus norvegicus (Norway rat) | Ki | 1.6000 | 1 | 1 |
| amitriptyline | Rattus norvegicus (Norway rat) | IC50 | 0.3000 | 1 | 3 |
| arecoline | Rattus norvegicus (Norway rat) | IC50 | 18.5117 | 7 | 12 |
| arecoline | Rattus norvegicus (Norway rat) | Ki | 2.2261 | 5 | 6 |
| benzylhydrochlorothiazide | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| bisacodyl | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| bithionol | Rattus norvegicus (Norway rat) | IC50 | 1.6700 | 1 | 0 |
| carbetapentane | Rattus norvegicus (Norway rat) | Ki | 0.0760 | 1 | 1 |
| chlorpromazine | Rattus norvegicus (Norway rat) | Ki | 0.0603 | 1 | 1 |
| cyproheptadine | Rattus norvegicus (Norway rat) | Ki | 0.0040 | 1 | 1 |
| safingol | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| profenamine | Rattus norvegicus (Norway rat) | IC50 | 0.7200 | 1 | 1 |
| gossypol | Rattus norvegicus (Norway rat) | IC50 | 0.8600 | 1 | 0 |
| haloperidol | Rattus norvegicus (Norway rat) | IC50 | 0.0540 | 1 | 1 |
| haloperidol | Rattus norvegicus (Norway rat) | Ki | 8.7066 | 2 | 2 |
| hexachlorophene | Rattus norvegicus (Norway rat) | IC50 | 0.8600 | 1 | 0 |
| methoctramine | Rattus norvegicus (Norway rat) | Ki | 0.0293 | 2 | 2 |
| 5-methylfurtrethonium | Rattus norvegicus (Norway rat) | IC50 | 0.0056 | 1 | 1 |
| methixene | Rattus norvegicus (Norway rat) | IC50 | 1.6000 | 1 | 1 |
| oxotremorine | Rattus norvegicus (Norway rat) | IC50 | 2.7261 | 8 | 13 |
| oxotremorine | Rattus norvegicus (Norway rat) | Ki | 9.7675 | 8 | 12 |
| periciazine | Rattus norvegicus (Norway rat) | IC50 | 0.2300 | 1 | 1 |
| phenazine | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| pirenzepine | Rattus norvegicus (Norway rat) | IC50 | 0.6227 | 33 | 43 |
| pirenzepine | Rattus norvegicus (Norway rat) | Ki | 0.1462 | 3 | 4 |
| spiperone | Rattus norvegicus (Norway rat) | Ki | 49.6000 | 1 | 1 |
| telenzepine | Rattus norvegicus (Norway rat) | Ki | 0.0174 | 1 | 1 |
| thioridazine | Rattus norvegicus (Norway rat) | IC50 | 0.1060 | 1 | 1 |
| triflupromazine | Rattus norvegicus (Norway rat) | IC50 | 7.4000 | 1 | 1 |
| carbachol | Rattus norvegicus (Norway rat) | IC50 | 12.6900 | 7 | 9 |
| carbachol | Rattus norvegicus (Norway rat) | Ki | 15.5317 | 8 | 11 |
| pilocarpine | Rattus norvegicus (Norway rat) | IC50 | 3.8400 | 2 | 2 |
| pilocarpine | Rattus norvegicus (Norway rat) | Ki | 3.6700 | 1 | 1 |
| caramiphen | Rattus norvegicus (Norway rat) | Ki | 0.0320 | 1 | 2 |
| bromobenzene | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| muscarine | Rattus norvegicus (Norway rat) | IC50 | 0.2410 | 2 | 2 |
| muscarine | Rattus norvegicus (Norway rat) | Ki | 2.0445 | 4 | 5 |
| 2-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(b,e)(1,4)diazepine | Rattus norvegicus (Norway rat) | Ki | 0.0209 | 1 | 1 |
| clothiapine | Rattus norvegicus (Norway rat) | Ki | 0.1349 | 1 | 1 |
| 6,7-Dimethyl-9-(2-acetoxyethyl)isoalloxazine | Rattus norvegicus (Norway rat) | IC50 | 18.7600 | 1 | 0 |
| quinuclidinyl benzilate | Rattus norvegicus (Norway rat) | Ki | 0.0002 | 1 | 2 |
| butaclamol | Rattus norvegicus (Norway rat) | Ki | 5.2000 | 1 | 1 |
| triadimenol | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| fluperlapine | Rattus norvegicus (Norway rat) | Ki | 0.0251 | 1 | 1 |
| n-methyl-n-(1-methyl-4-pyrrolidino-2-butynyl)acetamide | Rattus norvegicus (Norway rat) | Ki | 0.0498 | 4 | 6 |
| besipirdine | Rattus norvegicus (Norway rat) | IC50 | 2.3133 | 4 | 6 |
| n-methyl-3-piperidyl benzilate | Rattus norvegicus (Norway rat) | Ki | 0.0011 | 1 | 1 |
| n-ethyl-3-piperidyl benzilate | Rattus norvegicus (Norway rat) | Ki | 0.0015 | 1 | 1 |
| ticlopidine hydrochloride | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 2,3-trimethylene-4-quinazolone | Rattus norvegicus (Norway rat) | IC50 | 0.5200 | 1 | 0 |
| 2-aminodiphenylamine | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| prazosin hydrochloride | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 2,2'-((3,3'-dimethoxy(1,1'-biphenyl)-4,4'-diyl)diimino)bis-benzoic acid | Rattus norvegicus (Norway rat) | IC50 | 0.8500 | 1 | 0 |
| methyl fluorone black | Rattus norvegicus (Norway rat) | IC50 | 12.4600 | 1 | 0 |
| tetrandrine | Rattus norvegicus (Norway rat) | Ki | 0.0730 | 1 | 1 |
| enpiperate | Rattus norvegicus (Norway rat) | Ki | 0.0001 | 1 | 1 |
| nicotine | Rattus norvegicus (Norway rat) | IC50 | 360.0000 | 1 | 1 |
| nicotine | Rattus norvegicus (Norway rat) | Ki | 1.0597 | 2 | 2 |
| coumarin 7 | Rattus norvegicus (Norway rat) | IC50 | 1.6200 | 1 | 0 |
| afdx 116 | Rattus norvegicus (Norway rat) | IC50 | 2.9270 | 31 | 44 |
| 3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole | Rattus norvegicus (Norway rat) | Ki | 50.0000 | 1 | 1 |
| l 670548 | Rattus norvegicus (Norway rat) | Ki | 0.0002 | 1 | 2 |
| aq-ra 741 | Rattus norvegicus (Norway rat) | Ki | 0.0100 | 1 | 1 |
| tripitramine | Rattus norvegicus (Norway rat) | Ki | 0.0116 | 2 | 2 |
| hyoscyamine | Rattus norvegicus (Norway rat) | Ki | 0.0006 | 1 | 1 |
| guvacoline | Rattus norvegicus (Norway rat) | IC50 | 30.0000 | 1 | 1 |
| varenicline | Rattus norvegicus (Norway rat) | Ki | 0.0626 | 2 | 2 |
| atropine | Rattus norvegicus (Norway rat) | IC50 | 0.0010 | 2 | 3 |
| atropine | Rattus norvegicus (Norway rat) | Ki | 0.0008 | 4 | 7 |
| roxifiban | Rattus norvegicus (Norway rat) | IC50 | 0.0600 | 1 | 1 |
| dizocilpine | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| sdz ens 163 | Rattus norvegicus (Norway rat) | IC50 | 0.0540 | 1 | 1 |
| br 100 | Rattus norvegicus (Norway rat) | Ki | 1.3006 | 2 | 4 |
| gossypol acetic acid | Rattus norvegicus (Norway rat) | IC50 | 1.1700 | 1 | 0 |
| berbamine | Rattus norvegicus (Norway rat) | Ki | 0.1900 | 1 | 1 |
| enkephalin, methionine | Rattus norvegicus (Norway rat) | Ki | 0.0200 | 1 | 1 |
| 11-[2-[4-(2-aminoethyl)-1-piperazinyl]-1-oxoethyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one | Rattus norvegicus (Norway rat) | Ki | 2.8400 | 1 | 1 |
| 4-[[bis(2-hydroxyethyl)amino]methyl]-2,6-ditert-butylphenol | Rattus norvegicus (Norway rat) | IC50 | 1.6300 | 1 | 0 |
| 2-[(4,4-dimethyl-2,6-dioxocyclohexyl)-(3-pyridinyl)methyl]-5,5-dimethylcyclohexane-1,3-dione | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 2-(2-ethyl-6-methyl-3-oxo-1,4-benzoxazin-4-yl)-N-[(5-methyl-2-furanyl)methyl]-N-(3-pyridinylmethyl)acetamide | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 2-(2,5-dimethoxyphenyl)-5-[4-(4-methoxyphenyl)phenyl]-1,3,4-oxadiazole | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| N-[2-[2-[2-(4-methoxyanilino)-2-oxoethyl]-5-tetrazolyl]phenyl]-2-furancarboxamide | Rattus norvegicus (Norway rat) | IC50 | 6.2200 | 1 | 0 |
| N-[2-(3-pyridinyl)-1,3-benzoxazol-5-yl]butanamide | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 2-amino-4-(2-chlorophenyl)-6-(ethylthio)pyridine-3,5-dicarbonitrile | Rattus norvegicus (Norway rat) | IC50 | 0.4600 | 1 | 0 |
| N-butyl-N-[(6-methoxy-2-oxo-1H-quinolin-3-yl)methyl]-2-pyridinecarboxamide | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 9,10-dimethoxy-2-(2-pyridinylmethylamino)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one | Rattus norvegicus (Norway rat) | IC50 | 0.5500 | 1 | 0 |
| 4-(1-benzotriazolyl)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 3-cyclohexyl-1,1-bis(2-methylpropyl)thiourea | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 4-[oxo-(pyridin-4-ylamino)methyl]-1H-imidazole-5-carboxylic acid ethyl ester | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| [3-amino-6-(4-methoxyphenyl)-2-thieno[2,3-b]pyridinyl]-(3,4-dimethoxyphenyl)methanone | Rattus norvegicus (Norway rat) | IC50 | 0.5700 | 1 | 0 |
| 1-(3,4-dichlorophenyl)-3-(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)urea | Rattus norvegicus (Norway rat) | IC50 | 1.0500 | 1 | 0 |
| 4-morpholinyl-[5-thiophen-2-yl-7-(trifluoromethyl)-3-pyrazolo[1,5-a]pyrimidinyl]methanone | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| N-(2,6-dimethylphenyl)-2-[(6-methoxy-2-methyl-4-quinolinyl)thio]acetamide | Rattus norvegicus (Norway rat) | IC50 | 10.4700 | 1 | 0 |
| (E)-4-Phenyl-2-(3-(thiophen-2-yl)acrylamido)thiophene-3-carboxylic acid | Rattus norvegicus (Norway rat) | IC50 | 0.5400 | 1 | 0 |
| 5-(3,4-dimethoxyphenyl)-2-(4-methylphenyl)-4-thieno[2,3-d][1,3]oxazinone | Rattus norvegicus (Norway rat) | IC50 | 1.9800 | 1 | 0 |
| N-(6-chloro-1,3-benzothiazol-2-yl)-2-diphenylphosphorylacetamide | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 2-(benzenesulfonylmethyl)-5-(4-chlorophenyl)cyclohexane-1,3-dione | Rattus norvegicus (Norway rat) | IC50 | 2.3100 | 1 | 0 |
| N-[2-[tert-butyl(methyl)amino]ethyl]-N-methyl-2,2-diphenylacetamide | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 5-[(2-cyanoethylthio)methyl]-2-benzofurancarboxylic acid | Rattus norvegicus (Norway rat) | IC50 | 16.3900 | 1 | 0 |
| 3-(4-methylphenyl)sulfonylpropanoic acid [2-[(3,5-dichloro-2-pyridinyl)amino]-2-oxoethyl] ester | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 1-[1-(phenylmethyl)-4-piperidinyl]-3-(2,4,4-trimethylpentan-2-yl)thiourea | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 5-bromo-N-(4,7-dimethoxy-1,3-benzothiazol-2-yl)-2-thiophenecarboxamide | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 0 |
| 4E2RCat | Rattus norvegicus (Norway rat) | IC50 | 1.7000 | 1 | 0 |
| 1-[(7-chloro-4-quinolinyl)amino]-3-(2,4-dichlorophenyl)thiourea | Rattus norvegicus (Norway rat) | IC50 | 2.2200 | 1 | 0 |
| 1-(2-chlorophenyl)-N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-3-methyl-5-thieno[2,3-c]pyrazolecarboxamide | Rattus norvegicus (Norway rat) | IC50 | 1.6200 | 1 | 0 |
| 3-methyl-N-[(4-methylphenyl)methyl]-7,8-dihydro-6H-cyclopenta[4,5]thieno[1,2-c]pyrimidin-1-amine | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 3-methyl-2-thiophenecarboxylic acid [2-(4-morpholinyl)-2-oxoethyl] ester | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 2-(2,3-dihydro-1H-inden-5-yloxy)-1-(2,3-dihydroindol-1-yl)ethanone | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 7-[(4-acetylphenoxy)methyl]-5-thiazolo[3,2-a]pyrimidinone | Rattus norvegicus (Norway rat) | IC50 | 1.0400 | 1 | 0 |
| N-[4-methyl-5-[2-(3-nitroanilino)-4-thiazolyl]-2-thiazolyl]acetamide | Rattus norvegicus (Norway rat) | IC50 | 1.2800 | 1 | 0 |
| cb 7969312 | Rattus norvegicus (Norway rat) | IC50 | 0.5100 | 1 | 0 |
| 1-[2-furanyl(oxo)methyl]-6-(1-pyrrolidinylsulfonyl)-2-benzo[cd]indolone | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 3-(4-chlorophenyl)sulfonyl-N-[2,5-diethoxy-4-(4-morpholinyl)phenyl]propanamide | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| N-[4-[[2-(4-acetamidoanilino)-5-nitro-4-pyrimidinyl]amino]phenyl]acetamide | Rattus norvegicus (Norway rat) | IC50 | 10.8800 | 1 | 0 |
| 4-methyl-2-[3-methyl-4-(3-methylphenyl)azo-5-oxo-4H-pyrazol-1-yl]-5-thiazolecarboxylic acid ethyl ester | Rattus norvegicus (Norway rat) | IC50 | 1.4200 | 1 | 0 |
| N-[3,5-dimethyl-1-[(4-methylphenyl)methyl]-4-pyrazolyl]-2-[[4-(trifluoromethyl)-5,6-dihydrobenzo[h]quinazolin-2-yl]thio]acetamide | Rattus norvegicus (Norway rat) | IC50 | 1.9100 | 1 | 0 |
| 1-(3,5-dimethyl-1-piperidinyl)-2-[[2-(thiophen-2-ylmethyl)-4-quinazolinyl]thio]ethanone | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| N-(3-chlorophenyl)-4-[4-(3-methoxyphenyl)-2-thiazolyl]-1-piperazinecarbothioamide | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 2-(6-benzimidazolo[1,2-c]quinazolinylthio)-N-(2-furanylmethyl)acetamide | Rattus norvegicus (Norway rat) | IC50 | 2.5000 | 1 | 0 |
| N,N-diethyl-4-[[5-oxo-6-(phenylmethyl)-7H-pyrrolo[3,4-b]pyridin-7-yl]amino]benzenesulfonamide | Rattus norvegicus (Norway rat) | IC50 | 1.5200 | 1 | 0 |
| 2-(2-methoxyethyl)-9-methyl-4-[(4-methyl-1-piperidinyl)-oxomethyl]-1-pyrido[3,4-b]indolone | Rattus norvegicus (Norway rat) | IC50 | 53.0200 | 1 | 0 |
| 7-(5-chloro-2-methoxyanilino)-6-[(4-methoxyphenyl)methyl]-7H-pyrrolo[3,4-b]pyridin-5-one | Rattus norvegicus (Norway rat) | IC50 | 0.5300 | 1 | 0 |
| N-[5-ethyl-3-[(4-fluorophenyl)-(4-morpholinyl)methyl]-2-thiophenyl]benzamide | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 4-(4-chlorophenyl)-N-[3-[(4-methoxyphenyl)sulfamoyl]phenyl]-4-oxobutanamide | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| N-[3-(1,3-benzothiazol-2-yl)phenyl]-4-oxo-1-benzopyran-2-carboxamide | Rattus norvegicus (Norway rat) | IC50 | 2.3200 | 1 | 0 |
| 4-(6-methyl-4-phenyl-2-quinazolinyl)-1,3-dihydroquinoxalin-2-one | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| N-[1-[1-[2-[4-(diethylamino)anilino]-2-oxoethyl]-2-benzimidazolyl]ethyl]-4-methylbenzamide | Rattus norvegicus (Norway rat) | IC50 | 0.9000 | 1 | 0 |
| 8-(4-methoxyphenyl)-7-methyl-3-(phenylmethyl)purine-2,6-dione | Rattus norvegicus (Norway rat) | IC50 | 25.1700 | 1 | 0 |
| 2-nitro-4-[(6-nitro-4-quinolinyl)amino]-N-[4-(pyridin-4-ylamino)phenyl]benzamide | Rattus norvegicus (Norway rat) | IC50 | 1.3800 | 1 | 0 |
| ellagic acid | Rattus norvegicus (Norway rat) | IC50 | 0.5700 | 1 | 0 |
| naloxone | Rattus norvegicus (Norway rat) | Ki | 0.0011 | 1 | 5 |
| morphine | Rattus norvegicus (Norway rat) | Ki | 0.0320 | 2 | 6 |
| (2S)-2-(3-oxo-1H-isoindol-2-yl)-3-phenylpropanoic acid | Rattus norvegicus (Norway rat) | IC50 | 22.2900 | 1 | 0 |
| enkephalin, ala(2)-mephe(4)-gly(5)- | Rattus norvegicus (Norway rat) | IC50 | 0.0030 | 1 | 3 |
| N-[(2-methoxyphenyl)methyl]-6H-indolo[2,3-b]quinoxaline-2-carboxamide | Rattus norvegicus (Norway rat) | IC50 | 8.0700 | 1 | 0 |
| himbacine | Rattus norvegicus (Norway rat) | Ki | 0.0436 | 2 | 3 |
| vn2222 | Rattus norvegicus (Norway rat) | Ki | 5.0000 | 1 | 1 |
| tert-butyl peroxybenzoate | Rattus norvegicus (Norway rat) | IC50 | 0.4914 | 1 | 2 |
| iperoxo | Rattus norvegicus (Norway rat) | IC50 | 0.0013 | 1 | 1 |
| calpain inhibitor iii | Rattus norvegicus (Norway rat) | Ki | 0.0150 | 1 | 4 |
| scopolamine hydrobromide | Rattus norvegicus (Norway rat) | IC50 | 0.0060 | 3 | 3 |
| [4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-[(2S,4S)-4-(1-benzothiophen-3-yl)-2-[[4-(hydroxymethyl)phenyl]methoxy]-3,4-dihydro-2H-pyran-6-yl]methanone | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 2-amino-N-[3-methoxy-5-[oxo-[3-(trifluoromethyl)anilino]methyl]phenyl]-4-pyridinecarboxamide | Rattus norvegicus (Norway rat) | IC50 | 0.9100 | 1 | 0 |
| 7-spiroindanyloxymorphone | Rattus norvegicus (Norway rat) | Ki | 0.0106 | 1 | 2 |
| clozapine | Rattus norvegicus (Norway rat) | IC50 | 0.1534 | 4 | 5 |
| clozapine | Rattus norvegicus (Norway rat) | Ki | 0.0251 | 1 | 1 |
| flumezapine | Rattus norvegicus (Norway rat) | IC50 | 0.0780 | 3 | 3 |
| lomofungin | Rattus norvegicus (Norway rat) | IC50 | 3.2300 | 1 | 0 |
Drugs with Activation Measurements
Drugs with Other Measurements
In vitro muscarinic activity of spiromuscarones and related analogs.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists.Journal of medicinal chemistry, , Apr-02, Volume: 36, Issue:7, 1993
6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors.Journal of medicinal chemistry, , Jun-29, Volume: 43, Issue:13, 2000
6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors.Journal of medicinal chemistry, , Jun-04, Volume: 41, Issue:12, 1998
Conformationally constrained analogues of the muscarinic agonist 3-(4-(methylthio)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyr idine. Synthesis, receptor affinity, and antinociceptive activity.Journal of medicinal chemistry, , Jan-01, Volume: 41, Issue:1, 1998
In vitro muscarinic activity of spiromuscarones and related analogs.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists.Journal of medicinal chemistry, , Apr-02, Volume: 36, Issue:7, 1993
Muscarinic activity of the thiolactone, lactam, lactol, and thiolactol analogues of pilocarpine and a hypothetical model for the binding of agonists to the m1 receptor.Journal of medicinal chemistry, , Volume: 35, Issue:1, 1992
Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives.Journal of medicinal chemistry, , Apr-03, Volume: 35, Issue:7, 1992
Synthesis and muscarinic activity of quinuclidinyl- and (1-azanorbornyl)pyrazine derivatives.Journal of medicinal chemistry, , Jan-24, Volume: 35, Issue:2, 1992
Tetrahydropyridyloxadiazoles: semirigid muscarinic ligands.Journal of medicinal chemistry, , Volume: 34, Issue:3, 1991
Novel quinuclidine-based ligands for the muscarinic cholinergic receptor.Journal of medicinal chemistry, , Volume: 33, Issue:4, 1990
Synthesis and muscarinic activities of 1,2,4-thiadiazoles.Journal of medicinal chemistry, , Volume: 33, Issue:7, 1990
Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors.Journal of medicinal chemistry, , Volume: 33, Issue:10, 1990
Heterocyclic muscarinic agonists. Synthesis and biological activity of some bicyclic sulfonium arecoline bioisosteres.Journal of medicinal chemistry, , Volume: 31, Issue:7, 1988
A novel class of conformationally restricted heterocyclic muscarinic agonists.Journal of medicinal chemistry, , Volume: 29, Issue:6, 1986
Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study.Journal of medicinal chemistry, , Feb-18, Volume: 37, Issue:4, 1994
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.Journal of medicinal chemistry, , Volume: 30, Issue:8, 1987
Examination of a series of 8-[3-[bis(4-fluorophenyl)amino]propyl]-1-aryl-1,3,8- triazaspiro[4.5]decan-4-ones as potential antipsychotic agents.Journal of medicinal chemistry, , Volume: 28, Issue:12, 1985
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