A potassium voltage-gated channel subfamily E member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P15382]
Delayed rectifier potassium channel subunit IsK;
IKs producing slow voltage-gated potassium channel subunit beta Mink;
Minimal potassium channel
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| alfuzosin | Homo sapiens (human) | IC50 | 125.8930 | 1 | 1 |
| lamotrigine | Homo sapiens (human) | IC50 | 158.4890 | 1 | 1 |
| duloxetine | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| nelfinavir | Homo sapiens (human) | IC50 | 79.4328 | 1 | 1 |
| nebivolol | Homo sapiens (human) | IC50 | 27.8298 | 2 | 2 |
| uk 68798 | Homo sapiens (human) | IC50 | 204.8390 | 2 | 2 |
| doripenem | Homo sapiens (human) | IC50 | 316.2280 | 1 | 1 |
| tadalafil | Homo sapiens (human) | IC50 | 204.8390 | 2 | 2 |
| paliperidone | Homo sapiens (human) | IC50 | 251.1890 | 1 | 1 |
| 293b cpd | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| moxifloxacin | Homo sapiens (human) | IC50 | 278.2980 | 2 | 2 |
| solifenacin | Homo sapiens (human) | IC50 | 31.6228 | 1 | 1 |
| telbivudine | Homo sapiens (human) | IC50 | 251.1890 | 1 | 1 |
| etravirine | Homo sapiens (human) | IC50 | 1,258.9300 | 1 | 1 |
| lapatinib | Homo sapiens (human) | IC50 | 251.1890 | 1 | 1 |
| darunavir | Homo sapiens (human) | IC50 | 183.1734 | 2 | 2 |
| lacosamide | Homo sapiens (human) | IC50 | 251.1890 | 1 | 1 |
| tolterodine | Homo sapiens (human) | IC50 | 79.4328 | 1 | 1 |
| darifenacin | Homo sapiens (human) | IC50 | 19.9526 | 1 | 1 |
| s 1033 | Homo sapiens (human) | IC50 | 398.1070 | 1 | 1 |
| maraviroc | Homo sapiens (human) | IC50 | 63.0957 | 1 | 1 |
| dasatinib | Homo sapiens (human) | IC50 | 251.1890 | 1 | 1 |
| n-(6-chloropyridin-3-yl)-4-fluorobenzamide | Homo sapiens (human) | IC50 | 66.0000 | 1 | 1 |
| sitagliptin | Homo sapiens (human) | IC50 | 316.2280 | 1 | 1 |
| acacetin | Homo sapiens (human) | IC50 | 81.4000 | 1 | 0 |
| silodosin | Homo sapiens (human) | IC50 | 251.1890 | 1 | 1 |
| su 11248 | Homo sapiens (human) | IC50 | 63.0957 | 1 | 1 |
| alvimopan anhydrous | Homo sapiens (human) | IC50 | 50.1187 | 1 | 1 |
| palonosetron | Homo sapiens (human) | IC50 | 50.1187 | 1 | 1 |
| everolimus | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 6-cyano-4-(n-ethylsulfonyl-n-methylamino)-3-hydroxy-2,2-dimethylchromane, (trans-(+))-isomer | Homo sapiens (human) | IC50 | 24.7500 | 2 | 2 |
| lu 208075 | Homo sapiens (human) | IC50 | 282.1414 | 2 | 2 |
| hmr 1556 | Homo sapiens (human) | IC50 | 0.1200 | 2 | 2 |
| ica 27243 | Homo sapiens (human) | IC50 | 41.0000 | 1 | 1 |
| raltegravir | Homo sapiens (human) | IC50 | 25.1189 | 1 | 1 |
| mk-8825 | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| sildenafil | Homo sapiens (human) | IC50 | 278.2980 | 2 | 2 |
| vardenafil | Homo sapiens (human) | IC50 | 630.9570 | 1 | 1 |
This protein enables 6 target(s):
| Target | Category | Definition |
|---|---|---|
| delayed rectifier potassium channel activity | molecular function | Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow. [GOC:mah, PMID:11343411, PMID:2462513] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| potassium channel regulator activity | molecular function | Binds to and modulates the activity of a potassium channel. [GOC:dos, GOC:mah] |
| telethonin binding | molecular function | Binding to telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase. [GOC:mah, PMID:10481174] |
| protein-containing complex binding | molecular function | Binding to a macromolecular complex. [GOC:jl] |
| transmembrane transporter binding | molecular function | Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:BHF, GOC:jl, PMID:33199372] |
This protein is located in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| lysosome | cellular component | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| cell surface | cellular component | The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm] |
| apical plasma membrane | cellular component | The region of the plasma membrane located at the apical end of the cell. [GOC:curators] |
| Z disc | cellular component | Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. [GOC:mtg_muscle, ISBN:0815316194] |
| membrane raft | cellular component | Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. [PMID:16645198, PMID:20044567] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| voltage-gated potassium channel complex | cellular component | A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. [GOC:mah] |
This protein is involved in 24 target(s):
| Target | Category | Definition |
|---|---|---|
| epithelial cell maturation | biological process | The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. [GOC:dph] |
| sensory perception of sound | biological process | The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. [GOC:ai] |
| male gonad development | biological process | The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure. [GOC:jid] |
| vestibular nucleus development | biological process | The process whose specific outcome is the progression of the vestibular nucleus over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, PMID:16221589] |
| secretory granule organization | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. [GOC:mah] |
| regulation of ventricular cardiac muscle cell membrane repolarization | biological process | Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte. [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb] |
| cellular response to cAMP | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. [GOC:mah] |
| cellular response to acidic pH | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution. [GOC:go_curators, GOC:mah, Wikipedia:PH] |
| cellular response to light stimulus | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. [GOC:mah] |
| potassium ion transmembrane transport | biological process | A process in which a potassium ion is transported from one side of a membrane to the other. [GOC:mah] |
| cardiac muscle cell action potential involved in contraction | biological process | An action potential that occurs in a cardiac muscle cell and is involved in its contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| cardiac muscle cell contraction | biological process | The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a cardiac muscle cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| ventricular cardiac muscle cell action potential | biological process | An action potential that occurs in a ventricular cardiac muscle cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| membrane repolarization | biological process | The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| membrane repolarization during action potential | biological process | The process in which ions are transported across a membrane such that the membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| membrane repolarization during cardiac muscle cell action potential | biological process | The process in which ions are transported across a membrane such that the cardiac muscle cell plasma membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| regulation of heart rate by cardiac conduction | biological process | A cardiac conduction process that modulates the frequency or rate of heart contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| negative regulation of protein targeting to membrane | biological process | Any process that decreases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. [GOC:tb] |
| potassium ion export across plasma membrane | biological process | The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:vw, PMID:11932440] |
| membrane repolarization during ventricular cardiac muscle cell action potential | biological process | The process in which ions are transported across a membrane such that the ventricular cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb] |
| regulation of potassium ion transmembrane transport | biological process | Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport. [GOC:BHF, GOC:TermGenie] |
| positive regulation of potassium ion transmembrane transport | biological process | Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transport. [GOC:BHF, GOC:TermGenie] |
| regulation of delayed rectifier potassium channel activity | biological process | Any process that modulates the frequency, rate or extent of delayed rectifier potassium channel activity. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11299204] |
| negative regulation of delayed rectifier potassium channel activity | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of delayed rectifier potassium channel activity. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:11299204] |