Page last updated: 2024-11-12

kr-33028

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N-(4-cyano-benzo(b)thiophene-2-carbonyl)guanidine: a cardioprotective agent for preventing ischemia-reperfusion injury; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11515637
CHEMBL ID1184819
SCHEMBL ID825790
MeSH IDM0495679

Synonyms (11)

Synonym
n-(4-cyano-benzo(b)thiophene-2-carbonyl)guanidine
kr-33028
n-(4-cyano-benzo[b]thiophene-2-carbonyl)-guanidine; compound with methanesulfonic acid
bdbm50167868
CHEMBL1184819
SCHEMBL825790
n-[4-cyano-benzo[b]thiophene-2-carbonyl]guanidine
unii-fx7ef8axc3
fx7ef8axc3 ,
kr 33028
4-cyano-n-(diaminomethylidene)-1-benzothiophene-2-carboxamide

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" In this study, we characterized the pharmacodynamic properties of new guanidine NHE1 inhibitors (cariporide, sabiporide, KR-32511, KR-32570, and KR-33028) to analyze their myocardial protective effects."( Pharmacodynamic characteristics and cardioprotective effects of new NHE1 inhibitors.
Han, W; Jung, YS; Kim, J; Kim, KH; Kim, MY; Lee, BH; Lee, MG; Namkung, W; Yi, KY; Yoo, SE, 2007
)
0.54

Bioavailability

ExcerptReferenceRelevance
" There were nonlinear increases in AUC and C(max), and the absolute oral bioavailability (F) was significantly increased as the dose was increased (F = 23."( Dose-dependent pharmacokinetics of a new Na+/H+ exchanger inhibitor KR-33028 in rats.
Kim, YH; Kim, YS; Lee, HS; Lee, KH; Yoo, SD, 2007
)
0.58
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.16

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.16 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.16)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]