Proteins > Hsf1 protein
Page last updated: 2024-08-07 22:48:27

Hsf1 protein

[no definition available]

Synonyms

Research

Bioassay Publications (0)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0)18.7374
1990's0 (0)18.2507
2000's0 (0)29.6817
2010's0 (0)24.3611
2020's0 (0)2.80

Compounds (252)

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
gamma-aminobutyric acidMus musculus (house mouse)EC50195.000010
5-fluoroindole-2-carboxylic acidMus musculus (house mouse)EC50195.000010
bufexamacMus musculus (house mouse)EC50195.000010
hydrochlorothiazideMus musculus (house mouse)EC50195.000010
masoprocolMus musculus (house mouse)EC502.319010
piracetamMus musculus (house mouse)EC50195.000010
triamtereneMus musculus (house mouse)EC50195.000010
phentolamineMus musculus (house mouse)EC50195.000010
procaine hydrochlorideMus musculus (house mouse)EC50195.000010
tubercidinMus musculus (house mouse)EC503.057010
1-(2-pyridylazo)-2-naphtholMus musculus (house mouse)EC5011.371010
diatrizoate meglumineMus musculus (house mouse)EC50195.000010
2-fluoroadenosineMus musculus (house mouse)EC505.464010
2-phenylbenzimidazoleMus musculus (house mouse)EC50195.000010
fluorenone oximeMus musculus (house mouse)EC50260.000010
4-(4-dimethylaminophenylazo)benzoic acidMus musculus (house mouse)EC501.684010
isovelleralMus musculus (house mouse)EC500.530010
torsemideMus musculus (house mouse)EC50195.000010
lamivudineMus musculus (house mouse)EC500.287010
9-aminocamptothecinMus musculus (house mouse)EC50260.000010
9-methoxyellipticineMus musculus (house mouse)EC50260.000010
2-phenyl-4,5-dichloro-3-pyridazinoneMus musculus (house mouse)EC505.448010
2-methyl-4-nitroquinoline 1-oxideMus musculus (house mouse)EC506.352010
picloram-methylMus musculus (house mouse)EC50195.000010
1-(10-methyl-2-phenothiazinyl)ethanoneMus musculus (house mouse)EC50195.000010
7-amino-4-methylcoumarinMus musculus (house mouse)EC50260.000010
n-(6-methoxy-8-quinolyl)-4-toluenesulfonamideMus musculus (house mouse)EC5024.297010
xyloseMus musculus (house mouse)EC50195.000010
2,4-dinitropyrimidinyl-2-thiophenolMus musculus (house mouse)EC506.832010
4-methoxy-1-vinylcarbolineMus musculus (house mouse)EC509.196010
2-hydroxyestradiolMus musculus (house mouse)EC504.071010
anisomycinMus musculus (house mouse)EC500.243010
1-methyl-4-prop-2-enoxy-2-pyrimidinoneMus musculus (house mouse)EC50195.000010
5-(4-methylphenyl)-2H-tetrazoleMus musculus (house mouse)EC50260.000010
N-phenylcarbamic acid 2-phenoxyethyl esterMus musculus (house mouse)EC50195.000010
2,3-dichloro-5,8-dimethoxy-1,4-naphthoquinoneMus musculus (house mouse)EC504.558010
vinpocetineMus musculus (house mouse)EC50195.000010
2-(3-nitrophenyl)-5-phenyl-1,3,4-oxadiazoleMus musculus (house mouse)EC50195.000010
4-[2-(4-methoxycarbonylphenyl)iminohydrazinyl]benzoic acid methyl esterMus musculus (house mouse)EC50195.000010
2-[(4,4-dimethyl-2,6-dioxocyclohexyl)-(3-pyridinyl)methyl]-5,5-dimethylcyclohexane-1,3-dioneMus musculus (house mouse)EC50195.000010
idarubicin hydrochlorideMus musculus (house mouse)EC503.007010
3-(2-oxo-1,3-benzoxazol-3-yl)-N-phenylpropanamideMus musculus (house mouse)EC50260.000010
4-(4-fluorophenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid 1,3-benzodioxol-5-ylmethyl esterMus musculus (house mouse)EC500.160010
N-methyl-N-(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)-3-oxolanecarboxamideMus musculus (house mouse)EC50195.000010
2-[(2-phenyl-4-benzofuro[3,2-d]pyrimidinyl)thio]acetic acidMus musculus (house mouse)EC50195.000010
4-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxoethyl]-5-furo[3,2-b]pyrrolecarboxylic acid ethyl esterMus musculus (house mouse)EC50195.000010
1-(4-chlorophenyl)-2-[[4-ethyl-5-(2-methyl-3-furanyl)-1,2,4-triazol-3-yl]thio]ethanoneMus musculus (house mouse)EC50260.000010
1-[1,3-dimethyl-2-oxo-5-[[oxo(propylamino)methyl]amino]-4-imidazolidinyl]-3-propylureaMus musculus (house mouse)EC50195.000010
5H-quinolino[8,7-c][1,2]benzothiazine 6,6-dioxideMus musculus (house mouse)EC502.761010
8-[4-(3-chlorophenyl)-1-piperazinyl]-3-methyl-7-pentylpurine-2,6-dioneMus musculus (house mouse)EC50260.000010
2-[5-[(4-bromophenyl)methylthio]-4-(2-furanylmethyl)-1,2,4-triazol-3-yl]pyridineMus musculus (house mouse)EC5036.580010
2-(2-methoxyphenyl)-5-[2-(4-methoxyphenyl)ethylamino]-4-oxazolecarbonitrileMus musculus (house mouse)EC50260.000010
2-(2-furanyl)-5-[4-(phenylmethyl)-1-piperazinyl]-4-oxazolecarbonitrileMus musculus (house mouse)EC50195.000010
N-(5-methyl-7-phenyl-1,5,6,7-tetrahydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-2-thiophenecarboxamideMus musculus (house mouse)EC50195.000010
3-[(3aR,6aS)-6'-chloro-5-(4-chlorophenyl)-7'-methyl-2',4,6-trioxo-1-spiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]yl]propanamideMus musculus (house mouse)EC50260.000010
2-[2,4-dioxo-3-(phenylmethyl)-5-thiazolidinyl]acetic acidMus musculus (house mouse)EC50195.000010
6-amino-3-(methoxymethyl)-5-spiro[2H-pyrano[2,3-c]pyrazole-4,4'-thiane]carbonitrileMus musculus (house mouse)EC50195.000010
6-methyl-2-(trifluoromethyl)-3,5-dihydroimidazo[4,5-f]benzimidazoleMus musculus (house mouse)EC50260.000010
4-chloro-1-methyl-3-nitro-2-quinolinoneMus musculus (house mouse)EC504.301010
N-[2-(1H-benzimidazol-2-yl)ethyl]-4-chloro-3-nitrobenzamideMus musculus (house mouse)EC50260.000010
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-thiophenesulfonamideMus musculus (house mouse)EC502.913010
(3,5-dimethoxyphenyl)-(4-methylsulfonyl-1-piperazinyl)methanoneMus musculus (house mouse)EC50195.000010
N-(2-chlorophenyl)hydrazine-1-carbothioamideMus musculus (house mouse)EC50195.000010
3-cyclohexyl-1,1-bis(2-methylpropyl)thioureaMus musculus (house mouse)EC5017.050010
2-(Phenylthio)nicotinic acidMus musculus (house mouse)EC50260.000010
5-[(2-Chloro-6-fluorobenzyl)thio]-1,3,4-thiadiazol-2-amineMus musculus (house mouse)EC50260.000010
2,2,2-trifluoro-N-(2-methyl-8-quinolinyl)acetamideMus musculus (house mouse)EC50260.000010
4-(2-furanylmethyl)-3-pyridin-4-yl-1H-1,2,4-triazole-5-thioneMus musculus (house mouse)EC50195.000010
3-(4-bromophenyl)-6-phenyl-1,4-dihydro-1,3,5-triazine-2-thioneMus musculus (house mouse)EC50236.500010
1-[(4-phenyl-1-piperazinyl)methyl]-2-naphthalenolMus musculus (house mouse)EC5049.810010
3,5,5-trimethyl-4H-pyrazole-1-carbothioamideMus musculus (house mouse)EC50195.000010
1-(3-nitrophenyl)-3-phenyl-2-propyn-1-oneMus musculus (house mouse)EC50260.000010
3-(4-methylphenyl)sulfonyl-1,3-benzoxazol-2-oneMus musculus (house mouse)EC50260.000010
2-(4-ethoxyanilino)-1-(4-methylphenyl)ethanoneMus musculus (house mouse)EC50195.000010
2,3,4-trimethyl-N-(3-pyridinyl)benzenesulfonamideMus musculus (house mouse)EC50195.000010
N-(5-amino-1-phenyl-1,2,4-triazol-3-yl)-2,2,2-trichloroacetamideMus musculus (house mouse)EC50195.000010
4-tert-butyl-N-(1,4-dioxo-2,3-dihydrophthalazin-5-yl)benzamideMus musculus (house mouse)EC503.657010
N-[(4-fluoroanilino)-sulfanylidenemethyl]-2,3-dihydro-1,4-benzodioxin-6-carboxamideMus musculus (house mouse)EC50195.000010
1-(2-naphthalenyl)hexane-1,4-dioneMus musculus (house mouse)EC50195.000010
2-(4-methoxyphenyl)-3-(3-pyridinyl)-4-quinazolinoneMus musculus (house mouse)EC50195.000010
3,4-dichloro-N-[(1-methyl-4-pyrazolyl)methyl]-1-benzothiophene-2-carboxamideMus musculus (house mouse)EC50260.000010
LSM-31933Mus musculus (house mouse)EC50195.000010
1-[[2-(1-benzotriazolyl)-1-oxoethyl]amino]-3-cyclohexylthioureaMus musculus (house mouse)EC50195.000010
2-(4-methyl-1-piperazinyl)-N-(5-thiophen-2-yl-1,3,4-thiadiazol-2-yl)acetamideMus musculus (house mouse)EC50195.000010
N-tert-butyl-1,2-dihydroacenaphthylene-5-carboxamideMus musculus (house mouse)EC50260.000010
4-[[(cyclohexylamino)-oxomethyl]amino]benzoic acid methyl esterMus musculus (house mouse)EC50195.000010
3-(isopropylideneamino)-2,2-dimethyl-2,3-dihydroquinazolin-4(1h)-oneMus musculus (house mouse)EC50260.000010
2-(2,5-dimethylphenoxy)-N-(2-hydroxy-5-methylphenyl)acetamideMus musculus (house mouse)EC50260.000010
umi-77Mus musculus (house mouse)EC50260.000010
5-[(2,4-dichlorophenoxy)methyl]-N-[1-[(2-fluorophenyl)methyl]-3-pyrazolyl]-2-furancarboxamideMus musculus (house mouse)EC5020.840010
4-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-3-quinolinecarboxylic acid ethyl esterMus musculus (house mouse)EC506.001010
N-(3,5-dimethylphenyl)-4-(3-methoxyphenyl)-1-piperazinecarbothioamideMus musculus (house mouse)EC5094.426010
N-(3-methylphenyl)-4-(4-nitrophenyl)-2-phenyl-5-thiazolecarboxamideMus musculus (house mouse)EC50195.000010
2-fluoro-N-[2-(3-pyridinyl)-3H-benzimidazol-5-yl]benzamideMus musculus (house mouse)EC50195.000010
6-[[(4,6-dimethyl-2-pyrimidinyl)thio]methyl]-N2-(4-methoxyphenyl)-1,3,5-triazine-2,4-diamineMus musculus (house mouse)EC50195.000010
N-(1-naphthalenyl)-5-pyridin-4-yl-1,3,4-thiadiazol-2-amineMus musculus (house mouse)EC5042.070010
4-ethoxy-2,3,5-trimethyl-N-(3-pyridinylmethyl)benzenesulfonamideMus musculus (house mouse)EC50195.000010
5-nitro-N-[4-(2-oxazolo[4,5-b]pyridinyl)phenyl]-2-furancarboxamideMus musculus (house mouse)EC507.119010
2-[9-(3-chloro-4-methoxyphenyl)-1,8-dioxo-3,4,5,6,7,9-hexahydro-2H-acridin-10-yl]acetic acidMus musculus (house mouse)EC50260.000010
2-[[5-(1-benzotriazolylmethyl)-4-methyl-1,2,4-triazol-3-yl]thio]-1-(2-fluorophenyl)ethanoneMus musculus (house mouse)EC50260.000010
LSM-28492Mus musculus (house mouse)EC50260.000010
2-[[(2,3-dimethoxyphenyl)-oxomethyl]amino]-5-propan-2-yl-3-thiophenecarboxamideMus musculus (house mouse)EC50195.000010
1,3-diethyl-6-methyl-N-(2-methylphenyl)-2-oxo-5-benzimidazolesulfonamideMus musculus (house mouse)EC50260.000010
N-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]carbamic acid phenyl esterMus musculus (house mouse)EC50195.000010
3-(2-chlorophenyl)-5-methyl-N-[4-[2-(4-morpholinyl)-2-oxoethoxy]phenyl]-4-isoxazolecarboxamideMus musculus (house mouse)EC50195.000010
4-[[4-(2,3-dimethylphenyl)-1-piperazinyl]methyl]-2,6-dimethoxyphenolMus musculus (house mouse)EC50195.000010
2-[4-[[4-(4-methoxyphenyl)-1-phthalazinyl]amino]phenyl]acetamideMus musculus (house mouse)EC50260.000010
4-(4-methoxyphenyl)-3-(4-methylphenyl)-5-[(4-nitrophenyl)methylthio]-1,2,4-triazoleMus musculus (house mouse)EC50260.000010
N-[5-[(2,2-dimethyl-1-oxopropyl)amino]-2-pyridinyl]-2-furancarboxamideMus musculus (house mouse)EC500.160010
2,5-dichloro-N-(1,5,6-trimethyl-4-benzimidazolyl)benzenesulfonamideMus musculus (house mouse)EC50260.000010
4-(4-chlorophenyl)-1-(6-fluoro-2-pyridinyl)-3-pyrazolamineMus musculus (house mouse)EC50260.000010
7-(4-chlorophenyl)-2-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]thio]-[1,2,4]triazolo[1,5-a]pyrimidineMus musculus (house mouse)EC50260.000010
N2,N2-dimethyl-6-[[[1-(1-naphthalenyl)-5-tetrazolyl]thio]methyl]-1,3,5-triazine-2,4-diamineMus musculus (house mouse)EC50260.000010
7-methyl-4-oxo-2-[(phenylmethyl)amino]-3-pyrido[1,2-a]pyrimidinecarboxaldehydeMus musculus (house mouse)EC50260.000010
5-[diethylamino(oxo)methyl]-4-methyl-2-(1-oxopentylamino)-3-thiophenecarboxylic acid methyl esterMus musculus (house mouse)EC50195.000010
N-[4-(4-methyl-2-thiazolyl)-2-phenyl-3-pyrazolyl]-3-(trifluoromethyl)benzamideMus musculus (house mouse)EC50260.000010
3-[(5-chloro-2,4-dimethoxyphenyl)-methylsulfamoyl]-N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)benzamideMus musculus (house mouse)EC50203.200010
4-(4-chloro-2-methylphenoxy)-1-(4-morpholinyl)-1-butanoneMus musculus (house mouse)EC50195.000010
5-(2-furanyl)-N-[1-[(2-methylphenyl)methyl]-3-pyrazolyl]-7-(trifluoromethyl)-3-pyrazolo[1,5-a]pyrimidinecarboxamideMus musculus (house mouse)EC5019.097010
3-bromo-N-[(2-hydroxyethylamino)-sulfanylidenemethyl]-4-methoxybenzamideMus musculus (house mouse)EC50195.000010
2-[2-(3-ethylphenoxy)ethyl]propanedioic acid diethyl esterMus musculus (house mouse)EC5059.600010
3-[[(4-tert-butylphenyl)-oxomethyl]amino]-1H-1,2,4-triazole-5-carboxylic acid methyl esterMus musculus (house mouse)EC50195.000010
N-[4-(4-morpholinyl)phenyl]-2-pyridin-4-yl-4-quinolinecarboxamideMus musculus (house mouse)EC50195.000010
1-[1-(2-fluorophenyl)-2,5-dimethyl-3-pyrrolyl]-2-(4-methyl-1-piperidinyl)ethanoneMus musculus (house mouse)EC500.160010
1-(2-fluorophenyl)-1-cyclopentanecarboxylic acid [2-oxo-2-(4-sulfamoylanilino)ethyl] esterMus musculus (house mouse)EC5025.975010
thiocyanic acid [4-[(2-chloro-1-oxoethyl)amino]-3,5-dimethylphenyl] esterMus musculus (house mouse)EC505.969010
2-[[5-(2-furanyl)-1,3,4-oxadiazol-2-yl]thio]-1-(2-methoxyphenyl)ethanoneMus musculus (house mouse)EC5065.030010
2-chloro-1-[1-[2-(4-chlorophenyl)ethyl]-2,5-dimethyl-3-pyrrolyl]ethanoneMus musculus (house mouse)EC50260.000010
2-(2,6-dichlorophenyl)acetic acid [2-oxo-2-[4-(trifluoromethoxy)anilino]ethyl] esterMus musculus (house mouse)EC50195.000010
N-(1,3-benzodioxol-5-yl)-2-chloro-N-[(2-prop-2-enoxyphenyl)methyl]acetamideMus musculus (house mouse)EC504.875010
[4-(4-bromo-2-chlorophenyl)sulfonyl-1-piperazinyl]-(2-sulfanylidene-1H-pyridin-3-yl)methanoneMus musculus (house mouse)EC50260.000010
2-oxo-1H-pyridine-3-carboxylic acid [2-(2,5-dimethyl-1-propyl-3-pyrrolyl)-2-oxoethyl] esterMus musculus (house mouse)EC500.289010
2-[4-[(1-phenyl-5-tetrazolyl)oxy]phenyl]-1,3,4-oxadiazoleMus musculus (house mouse)EC50195.000010
2-(2,4-dibromophenoxy)-N-[oxo-(propan-2-ylamino)methyl]acetamideMus musculus (house mouse)EC50260.000010
ethylenethioureaMus musculus (house mouse)EC50195.000010
3,4-dimethyl-N-[4-(4-methylpiperazino)benzyl]benzamideMus musculus (house mouse)EC50195.000010
2-chloro-N-[(methylcarbamoylamino)-sulfanylidenemethyl]benzamideMus musculus (house mouse)EC50195.000010
3,3-dimethyl-2-morpholino-2,3-dihydrobenzo[b]furan-5-olMus musculus (house mouse)EC50260.000010
1-[2-(4-chlorophenyl)sulfonylethyl]-1-ethyl-3-phenylureaMus musculus (house mouse)EC50195.000010
2-[(4-chlorophenyl)methoxy]-6-methoxybenzonitrileMus musculus (house mouse)EC50260.000010
1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-5-ylthio)ethanoneMus musculus (house mouse)EC50260.000010
1-(1-benzotriazolyl)-3-(10-phenothiazinyl)-2-propanolMus musculus (house mouse)EC50260.000010
1,7,7-trimethyl-4-[(2-methyl-2,3-dihydroindol-1-yl)-oxomethyl]-2-bicyclo[2.2.1]heptanoneMus musculus (house mouse)EC50195.000010
N-tert-butyl-7,7-dimethyl-2-oxo-1,8-dioxaspiro[4.5]decane-4-carboxamideMus musculus (house mouse)EC50195.000010
[4-(benzenesulfonyl)-1-piperazinyl]-(1-piperidinyl)methanoneMus musculus (house mouse)EC5032.826010
4-[[1-[(3,4-dichlorophenyl)methyl]-3-indolyl]-(3-methyl-5-oxo-1,2-dihydropyrazol-4-yl)methyl]-5-methyl-1,2-dihydropyrazol-3-oneMus musculus (house mouse)EC5026.990010
LSM-25805Mus musculus (house mouse)EC50260.000010
N-[2,6-dimethyl-3-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-N,4-dimethylbenzenesulfonamideMus musculus (house mouse)EC50195.000010
2-[4-(1-adamantyl)-N-methylsulfonylanilino]acetic acidMus musculus (house mouse)EC50195.000010
4-[[2-(2,3-dihydro-1,4-benzodioxin-3-yl)-1-oxoethyl]amino]benzoic acid ethyl esterMus musculus (house mouse)EC50195.000010
2-[1-[[[(4-methoxyphenyl)-oxomethyl]amino]-sulfanylidenemethyl]-3-oxo-2-piperazinyl]acetic acid propan-2-yl esterMus musculus (house mouse)EC50195.000010
2-[(3-butan-2-yl-4-oxo-2-quinazolinyl)thio]propanenitrileMus musculus (house mouse)EC50195.000010
N-[(2-methoxyphenyl)methyl]-N-methyl-2,3-dihydro-1,4-benzodioxin-3-carboxamideMus musculus (house mouse)EC50195.000010
2-[[2-(4-chlorophenoxy)-1-oxoethyl]hydrazo]-N-(2-methoxy-5-methylphenyl)-2-oxoacetamideMus musculus (house mouse)EC5014.763010
2-[[5-(dimethylsulfamoyl)-1H-indol-3-yl]methylidene]propanedioic acid diethyl esterMus musculus (house mouse)EC5045.320010
2-(4-chlorophenoxy)-N-(5-nitro-2-thiazolyl)acetamideMus musculus (house mouse)EC500.382410
2-[7-oxo-7-(3-phenyl-1-pyrrolidinyl)heptyl]isoindole-1,3-dioneMus musculus (house mouse)EC50195.000010
5-(3,4-dimethoxyphenyl)-2-methylsulfonyl-3-thiophen-2-yl-3,4-dihydropyrazoleMus musculus (house mouse)EC50195.000010
N-[(6-methoxy-2-oxo-1H-quinolin-3-yl)methyl]-5-methyl-N-(thiophen-2-ylmethyl)-2,1,3-benzothiadiazole-4-sulfonamideMus musculus (house mouse)EC500.503010
1-cyclopentyl-1-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)ethyl]-3-(2-oxolanylmethyl)thioureaMus musculus (house mouse)EC50260.000010
[4-[5-tert-butyl-3-(phenylmethyl)-7-triazolo[4,5-d]pyrimidinyl]-1-piperazinyl]-(2-furanyl)methanoneMus musculus (house mouse)EC50195.000010
N-(1,3-benzothiazol-2-yl)-2-methoxy-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]benzamideMus musculus (house mouse)EC500.160010
3-[3-(4-methylphenyl)-6-oxo-1-pyridazinyl]-N-[2-(2-methyl-1-piperidinyl)ethyl]propanamideMus musculus (house mouse)EC50195.000010
N-[2-(2,4-dimethylphenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-1,3-benzodioxole-5-carboxamideMus musculus (house mouse)EC50260.000010
1-(4-methylphenyl)sulfonyl-3-methylsulfonylimidazolidineMus musculus (house mouse)EC50195.000010
1-oxo-N-(3-pyridinyl)-2-benzopyran-4-carboxamideMus musculus (house mouse)EC50195.000010
3-[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl]-1-methyl-2-indolecarboxylic acidMus musculus (house mouse)EC501.953010
2-(6-benzimidazolo[1,2-c]quinazolinylthio)-N-(2-furanylmethyl)acetamideMus musculus (house mouse)EC50260.000010
5-amino-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-4-triazolecarboxamideMus musculus (house mouse)EC500.440010
5-methyl-N-(5-methyl-2-phenyl-3-pyrazolyl)-3-isoxazolecarboxamideMus musculus (house mouse)EC50260.000010
4-[(3-oxo-4H-1,4-benzoxazin-7-yl)sulfonyl]-1-piperazinecarboxylic acid ethyl esterMus musculus (house mouse)EC50195.000010
6-[(2-chlorophenyl)methyl]-3-(3-methoxyphenyl)-7-triazolo[4,5-d]pyrimidinoneMus musculus (house mouse)EC50195.000010
3,4-dimethylbenzoic acid (6-methyl-3-pyridinyl) esterMus musculus (house mouse)EC50260.000010
1-[(5-bromo-2-thiophenyl)sulfonyl]-3-methylpiperidineMus musculus (house mouse)EC50195.000010
N-(4-fluorophenyl)-6-methyl-1-propyl-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine-2-carboxamideMus musculus (house mouse)EC50195.000010
2-amino-4-[4-(methylthio)phenyl]-5-oxo-1-phenyl-4,6,7,8-tetrahydroquinoline-3-carbonitrileMus musculus (house mouse)EC5026.960010
2-(1-ethyl-4-oxo-3-furo[3,4]pyrrolo[3,5-c][1,2,4]triazinyl)-N-[4-(2-furanyl)butan-2-yl]propanamideMus musculus (house mouse)EC50260.000010
N-(3-pyridinyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]isoxazole-3-carboxamideMus musculus (house mouse)EC500.288010
2-[(5-amino-1H-1,2,4-triazol-3-yl)thio]-N-(2-bromo-4-nitrophenyl)acetamideMus musculus (house mouse)EC50260.000010
5-[[(3,4-dichloroanilino)-sulfanylidenemethyl]amino]-1H-pyrazole-4-carboxylic acid methyl esterMus musculus (house mouse)EC500.249010
5-chloro-7-[(4-ethyl-1-piperazinyl)-(3-pyridinyl)methyl]-8-quinolinolMus musculus (house mouse)EC50195.000010
1-butyl-4,6-dimethyl-3-(2-methylphenyl)sulfonyl-2-pyridinoneMus musculus (house mouse)EC50195.000010
2-[[2-(3,4-dimethoxyphenyl)-6-methyl-1-benzopyran-4-ylidene]amino]butanoic acidMus musculus (house mouse)EC50195.000010
LSM-16912Mus musculus (house mouse)EC5018.459010
7-chloro-3-hydroxy-2-[3-(trifluoromethyl)phenyl]-4-quinazolinoneMus musculus (house mouse)EC50195.000010
2-amino-6-methyl-4-(3-pyridinyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrileMus musculus (house mouse)EC501.834010
1-(Chloroacetyl)-5-[4-(difluoromethoxy)-3-methoxyphenyl]-3-thien-2-yl-4,5-dihydro-1H-pyrazoleMus musculus (house mouse)EC503.041010
3-[[4-(diphenylmethyl)-1-piperazinyl]-oxomethyl]-7,8,9,10-tetrahydro-6H-azepino[2,1-b]quinazolin-12-oneMus musculus (house mouse)EC50260.000010
4-chloro-5-(2,3-dihydro-1,4-benzodioxin-3-yl)thieno[2,3-d]pyrimidineMus musculus (house mouse)EC5021.440010
4-[[2-[(1,1-dioxo-3-thiolanyl)amino]-2-oxoethyl]thio]-2,5-dimethyl-6-thieno[2,3-d]pyrimidinecarboxylic acid ethyl esterMus musculus (house mouse)EC50260.000010
4-(1H-benzimidazol-2-ylthio)-1-[4-(4-nitrophenyl)-1-piperazinyl]-1-butanoneMus musculus (house mouse)EC50260.000010
1-[2-(4-methoxyphenyl)-4-[oxo(1-pyrrolidinyl)methyl]-3-thiazolidinyl]-1-propanoneMus musculus (house mouse)EC5032.235010
N-cyclopropyl-2-[[2-(4-ethoxyphenyl)-5-methyl-4-oxazolyl]methylthio]acetamideMus musculus (house mouse)EC500.241010
3-[3-[4-(4-methoxyphenyl)-1-piperazinyl]propyl]-2-sulfanylidene-1H-pyrido[2,3-d]pyrimidin-4-oneMus musculus (house mouse)EC50195.000010
LSM-19765Mus musculus (house mouse)EC50260.000010
1-benzoyl-5-hydroxy-5-(4-methylphenyl)-4H-pyrazole-3-carboxylic acid ethyl esterMus musculus (house mouse)EC50260.000010
2-methyl-2,6-diphenyl-7-oxa-1-azabicyclo[2.2.1]heptaneMus musculus (house mouse)EC50260.000010
(4-methyl-1-piperazinyl)-(2-thieno[3,2-b][1]benzothiolyl)methanoneMus musculus (house mouse)EC50260.000010
2-chloro-N-(1,2-diphenylethyl)acetamideMus musculus (house mouse)EC5017.135010
4-[1-(4-fluorophenyl)-2-nitroethyl]-5-methyl-2-phenyl-1H-pyrazol-3-oneMus musculus (house mouse)EC50260.000010
4-dimethoxyphosphoryl-2-(1-naphthalenyl)-N-(phenylmethyl)-5-oxazolamineMus musculus (house mouse)EC50260.000010
3-[(4-methoxyphenoxy)methyl]-N-(4-nitro-1-pyrazolyl)benzamideMus musculus (house mouse)EC504.922010
[[2-[(4,5-dimethyl-2-thiazolyl)amino]-2-oxoethyl]thio]methanethioic acid O-ethyl esterMus musculus (house mouse)EC507.806010
N-[2-[4-(dimethylamino)phenyl]-2-(1H-indol-3-yl)ethyl]benzamideMus musculus (house mouse)EC50260.000010
2-[[(4-ethylphenyl)-oxomethyl]amino]-4-(methylthio)butanoic acid methyl esterMus musculus (house mouse)EC50195.000010
N-[2-[1-(3,5-dimethyl-1-piperidinyl)-1-oxopropan-2-yl]oxyphenyl]acetamideMus musculus (house mouse)EC50260.000010
N-(2-bromophenyl)-2-[5-(dimethylsulfamoyl)-2-(ethylamino)anilino]acetamideMus musculus (house mouse)EC50260.000010
2-(4-methylphenoxy)-N-[2-[oxo(1-piperidinyl)methyl]phenyl]acetamideMus musculus (house mouse)EC50195.000010
5-carbamoyl-4-methyl-2-[[1-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]amino]-3-thiophenecarboxylic acid ethyl esterMus musculus (house mouse)EC5024.972010
N-[1-[(4-fluorophenyl)methyl]-4-pyrazolyl]-5-(2-furanyl)-3-isoxazolecarboxamideMus musculus (house mouse)EC50195.000010
2-[(2-acetamido-1-oxoethyl)amino]-N-(4-methoxyphenyl)-2-(4-methylphenyl)acetamideMus musculus (house mouse)EC50195.000010
4-[5-(3-chlorophenyl)-2-furanyl]-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylic acid methyl esterMus musculus (house mouse)EC50260.000010
N-[5-(diethylsulfamoyl)-2-(4-morpholinyl)phenyl]-2-oxo-1-benzopyran-3-carboxamideMus musculus (house mouse)EC50260.000010
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,5-dimethyl-4-pyrazolecarboxamideMus musculus (house mouse)EC503.494010
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(2-methoxyethyl)-3-oxo-1H-isoindole-4-carboxamideMus musculus (house mouse)EC5011.639010
4-[[5-[(2,6-dichlorophenyl)sulfonylmethyl]-2-furanyl]-oxomethyl]-1-piperazinecarboxylic acid ethyl esterMus musculus (house mouse)EC50195.000010
LSM-28426Mus musculus (house mouse)EC50195.000010
2-[[cyclohexyl(oxo)methyl]amino]-3-thiophenecarboxamideMus musculus (house mouse)EC50195.000010
N-cycloheptyl-3-(2-methoxyethyl)-2,4-dioxo-1H-quinazoline-7-carboxamideMus musculus (house mouse)EC50195.000010
(5R)-3'-phenyl-1-(phenylmethyl)spiro[1,3-diazinane-5,5'-2,4,4a,6-tetrahydro-1H-pyrazino[1,2-a]quinoline]-2,4,6-trioneMus musculus (house mouse)EC50260.000010
enclomiphene citrateMus musculus (house mouse)EC50129.200010
chaetoglobosin AMus musculus (house mouse)EC506.243010
(3S)-2-(2-chloro-1-oxoethyl)-1,1-dimethyl-4,9-dihydro-3H-pyrido[3,4-b]indole-3-carboxylic acid methyl esterMus musculus (house mouse)EC504.076010
emetine hydrochlorideMus musculus (house mouse)EC500.160010
cycloheximideMus musculus (house mouse)EC500.660010
2-(2-furanyl)-N-phenyl-3-imidazo[1,2-a]pyridinamineMus musculus (house mouse)EC50151.000010
estradiol 17-acetateMus musculus (house mouse)EC50195.000010
2-[4-(2-pyrimidinyl)-1-piperazinyl]quinolineMus musculus (house mouse)EC50260.000010
N-cyclohexyl-2-[[6-(2-pyridinyl)-3-pyridazinyl]thio]acetamideMus musculus (house mouse)EC50195.000010
n-(4-methylthiazol-2-yl)-2-(6-phenylpyridazin-3-ylthio)acetamideMus musculus (house mouse)EC50195.000010
2-(1-methyl-4-oxo-3-furo[3,4]pyrrolo[3,5-c][1,2,4]triazinyl)-N-(3-phenylpropyl)propanamideMus musculus (house mouse)EC50195.000010
protoapigenoneMus musculus (house mouse)EC504.281010
N-[(4S)-4,6,6-trimethyl-3-bicyclo[3.1.1]heptanyl]benzamideMus musculus (house mouse)EC50260.000010
(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzodioxan hydrochlorideMus musculus (house mouse)EC50260.000010
2-(3-chloro-N-(2-chloro-1-oxoethyl)anilino)-N-cyclohexyl-2-(4-methoxyphenyl)acetamideMus musculus (house mouse)EC500.691010
3-[1-(4-bromophenyl)sulfonyl-3,6-dihydro-2H-pyridin-4-yl]-1,2-dimethylindoleMus musculus (house mouse)EC50195.000010
[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-[(2R,4R)-2-(4-hydroxybutoxy)-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-2H-pyran-6-yl]methanoneMus musculus (house mouse)EC50195.000010
[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-[(2R,4R)-4-(4-bromophenyl)-2-(4-hydroxybutoxy)-3,4-dihydro-2H-pyran-6-yl]methanoneMus musculus (house mouse)EC50195.000010
N-[[3-(2-chlorophenyl)-1-(4-fluorophenyl)-4-pyrazolyl]methyl]-2-(2-pyridinyl)ethanamineMus musculus (house mouse)EC50195.000010
[1-(2-benzofuranylmethyl)-4-[[3-(trifluoromethyl)phenyl]methyl]-4-piperidinyl]methanolMus musculus (house mouse)EC50260.000010
2-[(2-chloro-4-nitroanilino)methyl]-6-methoxyphenolMus musculus (house mouse)EC50163.000010
3-[4-(trifluoromethyl)phenyl]-N-[[2-(trifluoromethyl)phenyl]methyl]-4,5-dihydroisoxazole-5-carboxamideMus musculus (house mouse)EC50195.000010
6-[(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl]-2,4-dihydroxy-3-methylbenzaldehydeMus musculus (house mouse)EC5027.470010
3-phenylpropanoic acid [3-(4-cyanophenyl)-7-methyl-6,8-dioxo-2-[2-(2-pyridinyl)ethyl]-7-isoquinolinyl] esterMus musculus (house mouse)EC50195.000010
1-cyclohexyl-3-[1-(3,4-dimethoxyphenyl)ethyl]thioureaMus musculus (house mouse)EC50195.000010
4-(2-phenylethylsulfamoyl)-1H-pyrrole-2-carboxylic acid methyl esterMus musculus (house mouse)EC50195.000010
4-[(2S)-2-[2-(4-ethoxyphenyl)ethylamino]-3-[[(2S)-1-(methylamino)hexan-2-yl]amino]propyl]phenolMus musculus (house mouse)EC50195.000010
(3S)-3-cyclopentyl-4-oxo-3-phenyldiazetidine-1,2-dicarboxylic acid dimethyl esterMus musculus (house mouse)EC5014.930010
1-ethyl-N-(2-fluorophenyl)-4-hydroxy-2-oxo-3-quinolinecarboxamideMus musculus (house mouse)EC50195.000010
2-(methylthio)-6-(phenylmethyl)-1H-pyrimidin-4-oneMus musculus (house mouse)EC50195.000010
2-[(2-pyridinylthio)methyl]-1H-benzofuro[3,2-d]pyrimidin-4-oneMus musculus (house mouse)EC50260.000010
7,9-dimethyl-2-(phenylmethylthio)-1H-pyrido[2,3]thieno[2,4-b]pyrimidin-4-oneMus musculus (house mouse)EC50195.000010

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
piracetamMus musculus (house mouse)AC5080.139010
tubercidinMus musculus (house mouse)AC506.831020
2-fluoroadenosineMus musculus (house mouse)AC501.294020
fluorenone oximeMus musculus (house mouse)AbsAC40_uM15.780010
isovelleralMus musculus (house mouse)AC5017.914010
torsemideMus musculus (house mouse)AC5032.498010
9-aminocamptothecinMus musculus (house mouse)AbsAC40_uM15.890010
2-phenyl-4,5-dichloro-3-pyridazinoneMus musculus (house mouse)AC5014.403010
2-methyl-4-nitroquinoline 1-oxideMus musculus (house mouse)AC5010.747030
7-amino-4-methylcoumarinMus musculus (house mouse)AbsAC40_uM26.000010
n-(6-methoxy-8-quinolyl)-4-toluenesulfonamideMus musculus (house mouse)AC5033.013010
2-hydroxyestradiolMus musculus (house mouse)AbsAC40_uM25.200010
anisomycinMus musculus (house mouse)AC500.361030
2,3-dichloro-5,8-dimethoxy-1,4-naphthoquinoneMus musculus (house mouse)AC502.295010
4-(4-fluorophenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid 1,3-benzodioxol-5-ylmethyl esterMus musculus (house mouse)AC5022.111330
1-(4-chlorophenyl)-2-[[4-ethyl-5-(2-methyl-3-furanyl)-1,2,4-triazol-3-yl]thio]ethanoneMus musculus (house mouse)AbsAC40_uM11.050010
2-(2-methoxyphenyl)-5-[2-(4-methoxyphenyl)ethylamino]-4-oxazolecarbonitrileMus musculus (house mouse)AbsAC40_uM26.000010
3-[(3aR,6aS)-6'-chloro-5-(4-chlorophenyl)-7'-methyl-2',4,6-trioxo-1-spiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]yl]propanamideMus musculus (house mouse)AbsAC40_uM12.000010
4-chloro-1-methyl-3-nitro-2-quinolinoneMus musculus (house mouse)AC5014.164730
5-[(2-Chloro-6-fluorobenzyl)thio]-1,3,4-thiadiazol-2-amineMus musculus (house mouse)AbsAC40_uM14.410010
2,2,2-trifluoro-N-(2-methyl-8-quinolinyl)acetamideMus musculus (house mouse)AbsAC40_uM26.000010
4-(2-furanylmethyl)-3-pyridin-4-yl-1H-1,2,4-triazole-5-thioneMus musculus (house mouse)AC5032.002010
3-(4-bromophenyl)-6-phenyl-1,4-dihydro-1,3,5-triazine-2-thioneMus musculus (house mouse)AbsAC40_uM8.410010
2-(4-ethoxyanilino)-1-(4-methylphenyl)ethanoneMus musculus (house mouse)AC5012.738010
3-(isopropylideneamino)-2,2-dimethyl-2,3-dihydroquinazolin-4(1h)-oneMus musculus (house mouse)AbsAC40_uM26.000010
N-(1-naphthalenyl)-5-pyridin-4-yl-1,3,4-thiadiazol-2-amineMus musculus (house mouse)AbsAC40_uM1.240010
2-[9-(3-chloro-4-methoxyphenyl)-1,8-dioxo-3,4,5,6,7,9-hexahydro-2H-acridin-10-yl]acetic acidMus musculus (house mouse)AbsAC40_uM26.000010
2-[[5-(1-benzotriazolylmethyl)-4-methyl-1,2,4-triazol-3-yl]thio]-1-(2-fluorophenyl)ethanoneMus musculus (house mouse)AbsAC40_uM20.560010
7-methyl-4-oxo-2-[(phenylmethyl)amino]-3-pyrido[1,2-a]pyrimidinecarboxaldehydeMus musculus (house mouse)AbsAC40_uM11.040010
2-[2-(3-ethylphenoxy)ethyl]propanedioic acid diethyl esterMus musculus (house mouse)AbsAC40_uM26.000010
2-[[5-(2-furanyl)-1,3,4-oxadiazol-2-yl]thio]-1-(2-methoxyphenyl)ethanoneMus musculus (house mouse)AbsAC40_uM11.740010
[4-(4-bromo-2-chlorophenyl)sulfonyl-1-piperazinyl]-(2-sulfanylidene-1H-pyridin-3-yl)methanoneMus musculus (house mouse)AbsAC40_uM26.000010
3,3-dimethyl-2-morpholino-2,3-dihydrobenzo[b]furan-5-olMus musculus (house mouse)AbsAC40_uM26.000010
N-[(6-methoxy-2-oxo-1H-quinolin-3-yl)methyl]-5-methyl-N-(thiophen-2-ylmethyl)-2,1,3-benzothiadiazole-4-sulfonamideMus musculus (house mouse)AC50108.827020
[4-[5-tert-butyl-3-(phenylmethyl)-7-triazolo[4,5-d]pyrimidinyl]-1-piperazinyl]-(2-furanyl)methanoneMus musculus (house mouse)AC5021.777010
3-[3-(4-methylphenyl)-6-oxo-1-pyridazinyl]-N-[2-(2-methyl-1-piperidinyl)ethyl]propanamideMus musculus (house mouse)AC5044.723010
2-(6-benzimidazolo[1,2-c]quinazolinylthio)-N-(2-furanylmethyl)acetamideMus musculus (house mouse)AbsAC40_uM10.110010
4-[(3-oxo-4H-1,4-benzoxazin-7-yl)sulfonyl]-1-piperazinecarboxylic acid ethyl esterMus musculus (house mouse)AC50102.423010
2-[(5-amino-1H-1,2,4-triazol-3-yl)thio]-N-(2-bromo-4-nitrophenyl)acetamideMus musculus (house mouse)AbsAC40_uM26.000010
5-[[(3,4-dichloroanilino)-sulfanylidenemethyl]amino]-1H-pyrazole-4-carboxylic acid methyl esterMus musculus (house mouse)AC5026.851010
7-chloro-3-hydroxy-2-[3-(trifluoromethyl)phenyl]-4-quinazolinoneMus musculus (house mouse)AC5018.182010
2-amino-6-methyl-4-(3-pyridinyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrileMus musculus (house mouse)AC5069.070020
1-(Chloroacetyl)-5-[4-(difluoromethoxy)-3-methoxyphenyl]-3-thien-2-yl-4,5-dihydro-1H-pyrazoleMus musculus (house mouse)AC5014.816010
4-chloro-5-(2,3-dihydro-1,4-benzodioxin-3-yl)thieno[2,3-d]pyrimidineMus musculus (house mouse)AbsAC40_uM17.660010
4-[[2-[(1,1-dioxo-3-thiolanyl)amino]-2-oxoethyl]thio]-2,5-dimethyl-6-thieno[2,3-d]pyrimidinecarboxylic acid ethyl esterMus musculus (house mouse)AbsAC40_uM26.000010
1-benzoyl-5-hydroxy-5-(4-methylphenyl)-4H-pyrazole-3-carboxylic acid ethyl esterMus musculus (house mouse)AbsAC40_uM8.910010
3-[(4-methoxyphenoxy)methyl]-N-(4-nitro-1-pyrazolyl)benzamideMus musculus (house mouse)AC509.717010
[[2-[(4,5-dimethyl-2-thiazolyl)amino]-2-oxoethyl]thio]methanethioic acid O-ethyl esterMus musculus (house mouse)AbsAC40_uM12.390010
2-(4-methylphenoxy)-N-[2-[oxo(1-piperidinyl)methyl]phenyl]acetamideMus musculus (house mouse)AC5075.814010
4-[[5-[(2,6-dichlorophenyl)sulfonylmethyl]-2-furanyl]-oxomethyl]-1-piperazinecarboxylic acid ethyl esterMus musculus (house mouse)AC50167.978010
(5R)-3'-phenyl-1-(phenylmethyl)spiro[1,3-diazinane-5,5'-2,4,4a,6-tetrahydro-1H-pyrazino[1,2-a]quinoline]-2,4,6-trioneMus musculus (house mouse)AbsAC40_uM2.510010
emetine hydrochlorideMus musculus (house mouse)AC500.537520
cycloheximideMus musculus (house mouse)AC500.336010
N-[(4S)-4,6,6-trimethyl-3-bicyclo[3.1.1]heptanyl]benzamideMus musculus (house mouse)AbsAC40_uM26.000010
3-[1-(4-bromophenyl)sulfonyl-3,6-dihydro-2H-pyridin-4-yl]-1,2-dimethylindoleMus musculus (house mouse)AC50166.393010
3-[4-(trifluoromethyl)phenyl]-N-[[2-(trifluoromethyl)phenyl]methyl]-4,5-dihydroisoxazole-5-carboxamideMus musculus (house mouse)AC5022.986010
4-(2-phenylethylsulfamoyl)-1H-pyrrole-2-carboxylic acid methyl esterMus musculus (house mouse)AC5079.346010