Dual specificity protein phosphatase 3

A dual specificity protein phosphatase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51452]

Synonyms

EC 3.1.3.16;
EC 3.1.3.48;
Dual specificity protein phosphatase VHR;
Vaccinia H1-related phosphatase;
VHR

Research

Bioassay Publications (8)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (37.50)	29.6817
2010's	5 (62.50)	24.3611
2020's	0 (0.00)	2.80

Compounds (14)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
imperatorin	Homo sapiens (human)	IC50	100.0000	1	1
oleanolic acid	Homo sapiens (human)	IC50	5.4000	1	1
rac-glycerol 1-monodecanoate	Homo sapiens (human)	IC50	98.2000	1	1
6,7-dichloroquinoline-5,8-dione	Homo sapiens (human)	IC50	10.0000	1	1
nsc 663284	Homo sapiens (human)	IC50	4.0000	1	1
nsc668394	Homo sapiens (human)	IC50	8.5000	1	1
cefsulodin	Homo sapiens (human)	IC50	200.0000	1	1
caffeic acid	Homo sapiens (human)	IC50	100.0000	1	1
illudalic acid	Homo sapiens (human)	IC50	100.0000	1	1
linoleic acid	Homo sapiens (human)	IC50	100.0000	1	1
stigmasterol 3-o-beta-d-glucopyranoside	Homo sapiens (human)	IC50	60.7000	1	1
3-(1-(3-(biphenyl-4-ylamino)-3-oxopropyl)-1h-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1h-indole-5-carboxylic acid	Homo sapiens (human)	IC50	50.0000	1	1
rk 682	Homo sapiens (human)	IC50	11.1667	2	3
variabilin	Homo sapiens (human)	IC50	6.0000	1	1

Enables

This protein enables 10 target(s):

Target	Category	Definition
protein tyrosine phosphatase activity	molecular function	Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
cytoskeletal protein binding	molecular function	Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). [GOC:mah]
protein tyrosine/serine/threonine phosphatase activity	molecular function	Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [GOC:mah]
phosphatase activity	molecular function	Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions. [GOC:curators, GOC:pg]
myosin phosphatase activity	molecular function	Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate. [EC:3.1.3.16]
protein kinase binding	molecular function	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]
receptor tyrosine kinase binding	molecular function	Binding to a receptor that possesses protein tyrosine kinase activity. [GOC:mah]
MAP kinase phosphatase activity	molecular function	Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate. [GOC:mah, PMID:12184814, PMID:17208316]
protein tyrosine kinase binding	molecular function	Binding to protein tyrosine kinase. [PMID:25499537]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
immunological synapse	cellular component	An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. [GOC:mgi_curators, PMID:11244041, PMID:11376300]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 15 target(s):

Target	Category	Definition
dephosphorylation	biological process	The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. [ISBN:0198506732]
negative regulation of cell migration	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. [GOC:go_curators]
peptidyl-tyrosine dephosphorylation	biological process	The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine. [GOC:bf]
negative regulation of epidermal growth factor receptor signaling pathway	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. [GOC:go_curators]
negative regulation of MAPK cascade	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. [GOC:go_curators]
positive regulation of mitotic cell cycle	biological process	Any process that activates or increases the rate or extent of progression through the mitotic cell cycle. [GOC:dph, GOC:go_curators, GOC:tb]
negative regulation of JNK cascade	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade. [GOC:bf]
negative regulation of T cell receptor signaling pathway	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. [GOC:ai]
negative regulation of T cell activation	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation. [GOC:ai]
negative regulation of chemotaxis	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. [GOC:ai]
regulation of focal adhesion assembly	biological process	Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions. [GOC:ai]
negative regulation of ERK1 and ERK2 cascade	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:add, ISBN:0121245462, ISBN:0896039986]
cellular response to epidermal growth factor stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. [GOC:mah]
positive regulation of focal adhesion disassembly	biological process	Any process that activates or increases the frequency, rate or extent of disaggregation of a focal adhesion into its constituent components. [PMID:25490267]
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	biological process	Any peptidyl-tyrosine dephosphorylation that is involved in inactivation of protein kinase activity. [PMID:7501024]